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https://www.readbyqxmd.com/read/29222349/inequity-in-biological-dmard-prescription-for-spondyloarthritis-across-the-globe-results-from-the-asas-comospa-study
#1
Elena Nikiphorou, Désirée van der Heijde, Sam Norton, Robert Bm Landewé, Anna Molto, Maxime Dougados, Filip E Van den Bosch, Sofia Ramiro
OBJECTIVES: The value of biological disease-modifying antirheumatic drugs (bDMARDs) in spondyloarthritis (SpA) is well recognised, but global access to these treatments can be limited due to high costs and other factors. This study explores country variation in the use of bDMARDs in SpA in relation to country-level socioeconomic factors. METHODS: Patients fulfilling the Assessment in SpondyloArthritis International Society (ASAS) SpA criteria in the multinational, cross-sectional ASAS Comorbidities in Spondyloarthritis study were studied...
December 8, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29221961/prevalence-of-high-on-treatment-aspirin-and-clopidogrel-platelet-reactivity-in-patients-with-critical-limb-ischemia
#2
Leonardo C Clavijo, Noor Al-Asady, Ashwat Dhillon, Ray V Matthews, Jorge Caro, Han Tun, Vincent Rowe, David M Shavelle
OBJECTIVES: The goal of this study is to establish the prevalence of high on-treatment platelet reactivity to aspirin (HPRA) and clopidogrel (HPRC) in patients with critical limb ischemia (CLI). BACKGROUND: CLI is associated with an increased risk of death and cardiovascular events. Unlike other patient populations with atherosclerotic cardiovascular disease, previous studies failed to demonstrate a benefit of antiplatelet therapy in patients with CLI. METHODS: From June 2014 to November 2016, we performed platelet reactivity studies for P2Y12 and thromboxane A2 (TXA2) inhibition in 100 CLI patients receiving daily treatment with aspirin and clopidogrel...
October 28, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29220343/two-techniques-to-sample-non-volatiles-in-breath-exemplified-by-methadone
#3
Göran Ljungkvist, Shahid Ullah, Åsa Tinglev, Karina Stein, Björn Bake, Per Larsson, Ann-Charlotte Almstrand, Emilia Viklund, Oscar Hammar, Sören Sandqvist, Olof Beck, Anna-Carin Olin
The particles in exhaled breath provide a promising matrix for the monitoring of pathological processes in the airways, and also allow exposure to exogenous compounds to be to assessed. The collection is easy to perform and is non-invasive. The aim of the present study is to assess if an exogenous compound-methadone-is distributed in the lining fluid of small airways, and to compare two methods for collecting methadone in particles in exhaled breath. Exhaled particles were collected from 13 subjects receiving methadone maintenance treatment...
December 8, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29220068/assessing-the-decrease-in-the-surgical-population-of-the-university-of-puerto-rico-affiliated-hospitals
#4
Norma I Cruz, Elvis Santiago, César Luque
OBJECTIVE: To evaluate the magnitude of the decrease in the surgical population of the University of Puerto Rico (UPR)-affiliated hospitals. METHODS: We examined all the surgical cases that were entered into the Surgical Database from January 1, 2013, through December 31, 2015. This database collects patient and procedural information from the surgical services of the UPR-affiliated hospitals. Thus, the number of surgical patients for the 3-year study period was determined and their characteristics recorded...
December 2017: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/29219948/asperosaponin-vi-promotes-angiogenesis-and-accelerates-wound-healing-in-rats-via-up-regulating-hif-1%C3%AE-vegf-signaling
#5
Cheng-Gui Wang, Yi-Ting Lou, Min-Ji Tong, Li-Lian Zhang, Zeng-Jie Zhang, Yong-Zeng Feng, Shi Li, Hua-Zi Xu, Cong Mao
Wound therapy remains a clinical challenge due to the complexity of healing pathology and high demand of achieving functional and aesthetically satisfactory scars. Newly formed blood vessels are essential for tissue repair since they can support cells at the wound site with nutrition and oxygen. In this study, we investigated the effects of Asperosaponin VI (ASA VI) isolated from a traditional Chinese medicine, the root of Dipsacus asper Wall, in promoting angiogenesis, as well as its function in wound therapeutics...
December 7, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29217904/comparison-of-the-short-term-outcomes-of-laparoscopic-and-open-resections-for-colorectal-cancer-in-patients-with-a-history-of-prior-median-laparotomy
#6
Young Wan Kim, Ik Yong Kim
This study aimed to investigate the short-term outcomes of laparoscopic resection in comparison with those of open resection for colorectal cancer in patients with a history of prior median laparotomy (PML). Eighty-seven consecutive patients (87/1121, 7.8 %) with a history of PML who underwent major colorectal cancer resection were enrolled (laparoscopy, n = 40; open, n = 47). The conversion rate to open surgery was 25 % (n = 10). The laparoscopy group had a higher proportion of female patients (57...
December 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/29217899/technical-feasibility-and-short-term-outcome-of-intracorporeal-hand-sewn-esophagojejunostomy-after-laparoscopic-total-gastrectomy-our-experience
#7
Shailesh Puntambekar, Reda Badran, Hirav Parikh, Arpit Bansal, Vikrant Sharma, Mihir Chitale, Saptesh Jadhav
The purpose of this study was to demonstrate the safety and technical feasibility of intracorporeal hand-sewn esophagojejunostomy after laparoscopic total gastrectomy. Laparoscopic total gastrectomy (LTG) is a technically challenging procedure, especially for esophagojejunal anastomosis (EJA). Various techniques have been described to overcome these difficulties using staplers with variable results. We report successfully performed complete intracorporeal hand-sewn EJA after LTG. The perioperative clinical data and short-term outcomes for 30 patients who underwent LTG using hand-sewn EJA for gastric cancer between 2013 and 2015 have been retrospectively reviewed...
December 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/29217133/pge2-suppresses-human-group-2-innate-lymphoid-cell-function
#8
Jovana Maric, Avinash Ravindran, Luca Mazzurana, Åsa K Björklund, Aline Van Acker, Anna Rao, Danielle Friberg, Sven-Erik Dahlén, Akos Heinemann, Viktoria Konya, Jenny Mjösberg
BACKGROUND: Group 2 innate lymphoid cells (ILC2) are involved in the initial phase of type 2 inflammation and can amplify allergic immune responses by orchestrating other type 2 immune cells. PGE2 is a bioactive lipid that plays protective roles in the lung, particularly during allergic inflammation. OBJECTIVE: We set out to investigate how PGE2 regulates human ILC2 function. METHODS: The effects of PGE2 on human ILC2 proliferation, intracellular cytokine and transcription factor expression were assessed by flow cytometry...
December 4, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29216782/reduction-in-central-line-associated-bloodstream-infections-correlated-with-the-introduction-of-a-novel-silver-plated-dressing-for-central-venous-catheters-and-maintained-for-6-years
#9
Rachel Karlnoski, Elia Charbel Abboud, Peggy Thompson, Asa Z Oxner, John T Sinnott, Jorge E Marcet
OBJECTIVE: To assess a novel silver-plated dressing (SD) for central venous catheters in comparison to chlorhexidine gluconate-impregnated sponge (CHGIS) dressings in preventing central line-associated bloodstream infections (CLABSIs) in adult intensive care unit (ICU) patients. DESIGN: Retrospective cohort study. SETTING: Tampa General Hospital, an academic medical tertiary care center. PATIENTS: All adult ICU patients of an academic medical tertiary care center from January 2009 to December 2010...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29214676/platelet-function-monitoring-for-stent-thrombosis-in-critically-iii-patients-with-an-acute-coronary-syndrome
#10
Lisa Tilemann, Sarah K Mohr, Michael Preusch, Emanuel Chorianopoulos, Evangelos Giannitsis, Hugo A Katus, Oliver J Müller
BACKGROUND: Patients after cardiac arrest or in cardiogenic shock due to acute coronary syndrome (ACS) are at high risk for stent thrombosis (ST) and recurrent cardiovascular events after primary percutaneous coronary intervention (PCI). High post-interventional platelet reactivity (HPR) might be an additional risk factor for ST in these critically ill patients. METHODS: Between 2006 and 2016, 401 critically ill patients from a cardiologic intensive care unit underwent platelet function testing after primary PCI using whole blood impedance aggregometry...
December 6, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/29214382/bleeding-in-primary-shoulder-arthroplasty
#11
Dominik Malcherczyk, Asma Abdelmoula, Thomas J Heyse, Christian D Peterlein, Brandon Greene, Bilal F El-Zayat
INTRODUCTION: The aim of this investigation was to analyse "total blood loss" (TBL), "blood transfusion rate" (BT) and the "amount of transfused blood units" (BU) between the different primary shoulder arthroplasty (SA) types: reverse, anatomical and stemless. Only primary SA was included. Further goal was to identify risk factors for TBL, amount of BU and BT rate. METHODS: A retrospective charts analysis of patients who received primary SA for degenerative shoulder pathology in our institution between 2004 and 2016 was performed...
December 6, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29213213/-from-resistance-to-challenge-child-health-service-nurses-experiences-of-how-a-course-in-group-leadership-affected-their-management-of-parental-groups
#12
Åsa Lefèvre, Pia Lundqvist, Eva Drevenhorn, Inger Hallström
Background: All parents in Sweden are invited to child health service (CHS) parental groups, however only 49% of the families participate. The way the parental groups are managed has been shown to be of importance for how parents experience the support and CHS nurses describe feeling insecure when running the groups. Lack of facilitation, structure and leadership might jeopardise the potential benefit of such support groups. This study describes CHS nurses' experiences of how a course in group leadership affected the way they ran their parental groups...
2017: BMC Nursing
https://www.readbyqxmd.com/read/29212200/cell-free-dna-promoter-hypermethylation-in-plasma-as-a-predictive-marker-for-survival-of-patients-with-pancreatic-adenocarcinoma
#13
Stine Dam Henriksen, Poul Henning Madsen, Anders Christian Larsen, Martin Berg Johansen, Inge Søkilde Pedersen, Henrik Krarup, Ole Thorlacius-Ussing
Introduction: Few prognostic biomarkers are available for pancreatic cancer. The aim of this study is to examine the correlation between the survival of pancreatic adenocarcinoma patients and hypermethylated genes in plasma-derived cell-free DNA. Methods: Consecutive patients with pancreatic adenocarcinoma were prospectively included and staged according to the TNM classification. Methylation-specific PCR of 28 genes was conducted. A survival prediction model independent of cancer stage and stage-specific survival prediction models were developed by multivariable Cox regression analysis using backward stepwise selection...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29211190/incidence-and-risk-factors-for-surgical-site-infection-in-general-surgeries
#14
Rafael Lima Rodrigues de Carvalho, Camila Cláudia Campos, Lúcia Maciel de Castro Franco, Adelaide De Mattia Rocha, Flávia Falci Ercole
OBJECTIVE: to estimate the incidence of surgical site infection in general surgeries at a large Brazilian hospital while identifying risk factors and prevalent microorganisms. METHOD: non-concurrent cohort study with 16,882 information of patients undergoing general surgery from 2008 to 2011. Data were analyzed by descriptive, bivariate and multivariate analysis. RESULTS: the incidence of surgical site infection was 3.4%. The risk factors associated with surgical site infection were: length of preoperative hospital stay more than 24 hours; duration of surgery in hours; wound class clean-contaminated, contaminated and dirty/infected; and ASA index classified into ASA II, III and IV/V...
December 4, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/29209875/non-routine-discharge-disposition-is-associated-with-post-discharge-complications-and-30-day-readmissions-following-craniotomy-for-brain-tumor-resection
#15
Nikita Lakomkin, Constantinos G Hadjipanayis
Several studies have reported an association between high-volume brain tumor centers and greater rates of routine discharge disposition in the context of better outcomes. However, the relationship between in-hospital complications, discharge destination, and postoperative adverse events (AEs) remains unexplored. The purpose of this study was thus to use a large, prospectively collected database to examine the association between discharge destination, post-discharge complications, readmissions, and reoperations among patients undergoing craniotomy for brain tumor...
December 5, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29209128/role-of-combined-propofol-and-sufentanil-anesthesia-in-endoscopic-injection-sclerotherapy-for-esophageal-varices
#16
Yang Yu, Sheng-Lin Qi, Yong Zhang
AIM: To investigate the efficacy and safety of a combination of sufentanil and propofol injection in patients undergoing endoscopic injection sclerotherapy (EIS) for esophageal varices (EVs). METHODS: Patients with severe EVs who underwent EIS with sufentanil and propofol anesthesia between April 2016 and July 2016 at our hospital were reviewed. Although EIS and sequential therapy were performed under endotracheal intubation, we only evaluated the efficacy and safety of anesthesia for the first EIS procedure...
November 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29208884/role-of-oral-clonidine-premedication-on-intra-operative-haemodynamics-and-ponv-in-laparoscopic-cholecystectomy
#17
M Masud, S Yeasmeen, A K Haque, S Jahan, N C Saha, D Banik
Laparoscopic cholecystectomy is a gold standard surgical procedure for gallbladder operation. It causes altered haemodynamic responses due to pneumoperitoneum and surgical procedure also causes high incidence of postoperative nausea &vomiting. Clonidine has been shown to reduce intraoperative haemodynamic instability. This randomized prospective single blind clinical study was designed to evaluate the efficacy of oral clonidine premedication for attenuation of haemodynamic responses associated with pneumoperitoneum & also reduce the incidence of postoperative nausea & vomiting and carried out in the department of Anaesthesia Analgesia and Intensive care Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from January 2010 to June 2010...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29208716/direct-measurements-of-meltwater-runoff-on-the-greenland-ice-sheet-surface
#18
Laurence C Smith, Kang Yang, Lincoln H Pitcher, Brandon T Overstreet, Vena W Chu, Åsa K Rennermalm, Jonathan C Ryan, Matthew G Cooper, Colin J Gleason, Marco Tedesco, Jeyavinoth Jeyaratnam, Dirk van As, Michiel R van den Broeke, Willem Jan van de Berg, Brice Noël, Peter L Langen, Richard I Cullather, Bin Zhao, Michael J Willis, Alun Hubbard, Jason E Box, Brittany A Jenner, Alberto E Behar
Meltwater runoff from the Greenland ice sheet surface influences surface mass balance (SMB), ice dynamics, and global sea level rise, but is estimated with climate models and thus difficult to validate. We present a way to measure ice surface runoff directly, from hourly in situ supraglacial river discharge measurements and simultaneous high-resolution satellite/drone remote sensing of upstream fluvial catchment area. A first 72-h trial for a 63.1-km2 moulin-terminating internally drained catchment (IDC) on Greenland's midelevation (1,207-1,381 m above sea level) ablation zone is compared with melt and runoff simulations from HIRHAM5, MAR3...
December 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29208680/subtle-modifications-to-oxytocin-produce-ligands-that-retain-potency-and-improved-selectivity-across-species
#19
Markus Muttenthaler, Åsa Andersson, Irina Vetter, Rohit Menon, Marta Busnelli, Lotten Ragnarsson, Christian Bergmayr, Sarah Arrowsmith, Jennifer R Deuis, Han Sheng Chiu, Nathan J Palpant, Margaret O'Brien, Terry J Smith, Susan Wray, Inga D Neumann, Christian W Gruber, Richard J Lewis, Paul F Alewood
Oxytocin and vasopressin mediate various physiological functions that are important for osmoregulation, reproduction, cardiovascular function, social behavior, memory, and learning through four G protein-coupled receptors that are also implicated in high-profile disorders. Targeting these receptors is challenging because of the difficulty in obtaining ligands that retain selectivity across rodents and humans for translational studies. We identified a selective and more stable oxytocin receptor (OTR) agonist by subtly modifying the pharmacophore framework of human oxytocin and vasopressin...
December 5, 2017: Science Signaling
https://www.readbyqxmd.com/read/29207972/disparities-in-the-regional-hospital-and-individual-levels-of-antibiotic-use-in-gallstone-surgery-in-sweden
#20
Gona Jaafar, Bahman Darkahi, Lars Lindhagen, Gunnar Persson, Gabriel Sandblom
BACKGROUND: Antimicrobial resistance may be promoted by divergent routines and lack of conformity in antibiotic treatment, especially regarding the practice of antibiotic prophylaxis. The aim of the present study was to assess differences in gallstone surgery regarding antibiotic use in Sweden. METHODS: The study was based on data from the Swedish Register for Gallstone Surgery and ERCP (GallRiks) 2005-2015. Funnel plots were used to test impact of grouping factors, including, hospital and surgeon and to identify units that deviated from the rest of the population...
December 6, 2017: BMC Surgery
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