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Keratocystic odontogenic tumor

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https://www.readbyqxmd.com/read/29892529/quantitative-analysis-of-argyrophilic-nucleolar-organizer-regions-in-odontogenic-cysts-and-tumor-a-comparative-study
#1
Bhavana Gupta, Shaleen Chandra, Vineet Raj, Vivek Gupta
Background: The nucleolar organizer region (NOR) is by definition part of a chromosome, and nucleolus is a structure containing this chromosomal part and in addition the material which accumulate around the NOR, mostly rRNAs and their precursors as well as specific ribosomal proteins. Argyrophilic Nucleolar organizing region (AgNOR) are silver binding NORs often used to study cell proliferation in various types of tumors. Aim: Quantitative assessment of Argyrophilic Nucleolar organizing region count and its comparison among dentigerous cyst, keratocystic odontogenic tumor and ameloblastoma...
May 2018: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/29892328/a-case-of-an-extensive-keratocystic-odontogenic-tumor-in-the-mandible-reconstructed-with-a-custom-made-total-joint-prosthesis
#2
Payam Farzad
The use of virtual surgical planning and computer-aided design/computer-aided manufacturing has previously been reported to enhance the planning for the reconstruction of mandibular continuity defects and to reduce surgical time. Reported is a case of a large keratocystic odontogenic tumor (KOT) affecting right hemimandible including the condylar neck. This case was initially reconstructed with a condyle-bearing reconstruction plate, but because of fatigue fracture 15 years later, a new reconstruction with a custom-made total joint temporomandibular prosthesis was performed...
June 2018: Craniomaxillofacial Trauma & Reconstruction
https://www.readbyqxmd.com/read/29850338/initial-stage-primary-intraosseous-squamous-cell-carcinoma-derived-from-odontogenic-keratocyst-with-unusual-keratoameloblastomatous-change-of-the-maxilla-a-case-report-and-literature-discussion
#3
Kentaro Kikuchi, Fumio Ide, Shota Takizawa, Seiji Suzuki, Hideaki Sakashita, Tie-Jun Li, Kaoru Kusama
Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare malignant neoplasm derived from odontogenic epithelial remnants in the central jaw bone. Most PIOSCCs originate from odontogenic cysts with a nonkeratinized epithelial lining, especially from radicular/residual and dentigerous cysts. There have been few reports of PIOSCCs derived from the odontogenic keratocyst (OKC), particularly those describing pathological features at the initial stage. The diagnosis of PIOSCC is difficult and based on exclusion of other carcinomas, including metastatic tumors from other primary sites...
2018: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/29802703/amelogenin-is-a-potential-biomarker-for-the-aggressiveness-in-odontogenic-tumors
#4
Safa Zakaraia, Mamdouh Almohareb, Khaled Zaid, Mazen Doumani, Mohammad Yaman Seirawan
Amelogenin (AMEL), the major structural protein of the enamel organic matrix, constitutes more than 90% of the enamel’s protein content, Aberrations of amelogenin are thought to be involved in the oncogenesis of odontogenic epithelium. The expression of amelogenin is possibly an indicator of differentiation of epithelial cells in the odontogenic tumors. Aim of the study: Investigating the expression of amelogenin in some odontogenic tumors, using an anti-amelogenin polyclonal antibody, and then compare it with AMEL expression in tooth buds as control...
May 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29657523/comparison-of-osteoclastogenesis-and-local-invasiveness-of-ameloblastoma-and-keratocystic-odontogenic-tumor
#5
Natheer H Al-Rawi, Ammar K Al-Siraj, Ahlam H Majeed
Objectives: The aim of this study was to compare the expression of receptor-activated nuclear factor kappa B (RANK) with its ligand (RANKL) and matrix metalloproteinase-2 (MMP2) in solid/multicystic ameloblastomas (ABs) and keratocystic odontogenic tumors (KOTs). Materials and Methods: The expression of MMP2, RANK, and RANKL molecules was evaluated in 13 ABs and 14 KOTs by immunohistochemistry. The expressions were calculated in the odontogenic epithelial cells as well as the stromal cells...
January 2018: European Journal of Dentistry
https://www.readbyqxmd.com/read/29577431/is-podoplanin-expression-associated-with-transforming-growth-factor-%C3%AE-signaling-in-odontogenic-cysts-and-tumors
#6
Shahroo Etemad-Moghadam, Mojgan Alaeddini
BACKGROUND: Induction of podoplanin by transforming growth factor-β (TGF-β) has been shown in a number of lesions but not in odontogenic tumors (OTs). We evaluated the association between these markers in OTs for the first time and compared their expression among the different neoplasms. METHODS: Immunohistochemistry using monoclonal antibody against podoplanin and TGF-β was performed on 76 odontogenic cysts and tumors. Spearman's correlation coefficient, Kruskal-Wallis, and Mann-Whitney U tests followed by adjustment with Bonferroni were used for statistical analysis (P < ...
May 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29491624/trigeminal-neuralgia-induced-by-odontogenic-keratocyst-associated-with-impacted-supernumerary-teeth-a-rare-case-report
#7
Annaji Araleri Gopalkrishna, B N Tejasree, M Manjunath, D P Ashwin
Odontogenic keratocyst(OKC)is a cyst oftooth origin with an aggressive behavior including a high recurrence rate, it has been rechristened to keratocystic odontogenic tumor(KCOT) as it be the reflects its neoplastic nature. We report a case of KCOT in association with an impacted supernumerary tooth along with Trigeminal Neuralgia, that subsided by itself after removal of the cyst.
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29491599/orthokeratinized-odontogenic-cyst-with-calcification-a-rare-case-report-of-a-distinct-entity
#8
Mamata Kamat, Sampada Kanitkar, Uma Datar, Sanjay Byakodi
Orthokeratinized odontogenic cyst (OOC) is a relatively rare odontogenic cyst, distinct from odontogenic keratocyst (OKC). In the 4th edition of WHO Classification of Head and Neck Tumors (2017), OOC has been included as a separate entity in the category of developmental odontogenic cysts. It presents as a unilocular radiolucent lesion in the posterior mandible and is frequently related to impacted teeth, thus mimicking dentigerous cyst. Due to low local aggressiveness and no association with nevoid basal cell carcinoma syndrome, it does not show tendency to recur...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29476674/apoptosis-and-cell-cycle-aberrations-in-epithelial-odontogenic-lesions-an-evidence-by-the-expression-of-p53-bcl-2-and-bax
#9
J-R Tenório, T Santana, S-I-M-L Queiroz, D-H-I-P de Oliveira, L-M-G Queiroz
BACKGROUND: Ameloblastoma (AMB), odontogenic keratocyst (OKC) and adenomatoid odontogenic tumor (AOT) are epithelial odontogenic lesions with diverse biologic profiles. Defects in regulation of apoptosis and cell cycle may be involved in the development and progression of those lesions, therefore we aimed to investigate the expression of Bcl-2, Bax and p53 to better understand the possible role of these proteins in AMBs, OKCs and AOTs. MATERIAL AND METHODS: The studied sample consisted of 20 AMBs, 20 OKCs and 20 AOTs...
March 1, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29472118/loss-of-heterozygosity-of-mir15a-mir16-1-negative-regulators-of-the-antiapoptotic-gene-bcl2-is-not-common-in-odontogenic-keratocysts
#10
Taynara Asevedo Campos de Resende, Vanessa de Fátima Bernardes, Jéssica Carolina da Silva, Luiz Armando De Marco, Ricardo Santiago Gomez, Carolina Cavalieri Gomes, Marina Gonçalves Diniz
OBJECTIVES: The odontogenic keratocyst (OKC) is an aggressive odontogenic cyst that has a high recurrence rate. Apart from PTCH1 mutations, few molecular alterations are described in OKCs. Low expression of microRNAs (miRNAs) miR-15a and/or miR-16-1 in association with increased expression of their target, Bcl-2, have been previously found in OKC. In humans, MIR15A and MIR16-1 are clustered at chromosome position 13 q14, and loss of heterozygosity (LOH) at this locus occurs in different tumors...
April 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29391730/odontogenic-tumors-review-of-127-cases-in-marathwada-region-of-maharashtra
#11
Atul Bhagwat, S R Barpande, J D Bhavthankar, M S Mandale, Jayanti Humbe, Preeti Singh
Introduction: Odontogenic tumors (OTs) are a group of heterogeneous lesions derived from epithelial or ectomesenchymal tissues or both, which are part of the tooth-forming apparatus. They range from hamartomatous or nonneoplastic tissue proliferations to malignant neoplasms with metastatic capacity. OTs are comparatively rare, comprising about 4.79% of all oral and maxillofacial biopsy specimens diagnosed. Several retrospective studies carried out in Africa, Asia, Europe and America, show that differences exist in the relative frequency of the various histologic types...
September 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29391711/immunohistochemical-evaluation-of-inducible-nitric-oxide-synthase-in-the-epithelial-lining-of-odontogenic-cysts-a-qualitative-and-quantitative-analysis
#12
B K Akshatha, Karpagaselvi Karuppiah, G S Manjunath, Jayalakshmi Kumarswamy, Lokesh Papaiah, Jyothi Rao
Introduction: The three common odontogenic cysts include radicular cysts (RCs), dentigerous cysts (DCs), and odontogenic keratocysts (OKCs). Among these 3 cysts, OKC is recently been classified as benign keratocystic odontogenic tumor attributing to its aggressive behavior, recurrence rate, and malignant potential. The present study involved qualitative and quantitative analysis of inducible nitric oxide synthase (iNOS) expression in epithelial lining of RCs, DCs, and OKCs, compare iNOS expression in epithelial linings of all the 3 cysts and determined overexpression of iNOS in OKCs which might contribute to its aggressive behavior and malignant potential...
September 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29383694/evaluation-of-midkine-expression-in-dentigerous-cysts-odontogenic-keratocysts-and-different-types-of-ameloblastoma
#13
Naghmeh Jeiroodi, Mahshid Bagherpour, Razieh Zare, Shima Torabi-Ardakani, Azadeh Andisheh-Tadbir
OBJECTIVE: Midkine is a heparin-binding growth factor whose expression is increased in most tumors, namely ameloblastomas. This study aimed to compare Midkine expression in different odontogenic lesions. MATERIAL AND METHOD: This analytical cross-sectional study was performed on 52 definitely diagnosed odontogenic lesions including 15 dentigerous cysts, 13 odontogenic keratocysts, and 17 unicystic and 5 multicystic ameloblastomas archived from 1997 to 2015. Midkine expression was examined in tissue samples through immunohistochemistry...
January 31, 2018: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/29381605/novel-ptch1-gene-mutation-in-nevoid-basal-cell-carcinoma-syndrome
#14
Yookyeong Carolyn Sim, Gu-Hwan Kim, Sung-Weon Choi, Kang-Min Ahn
The purpose of this study was to report clinical characteristics, surgical results, and new PTCH1 gene mutations in nevoid basal cell carcinoma syndrome (NBCCS). Five patients were referred to the Department of Oral and Maxillofacial Surgery from local dental clinics between 2006 and 2016 to treat multiple keratocystic odontogenic tumors (KOTs). The cystic lesions were enucleated and peripheral ostectomy was performed to obtain safety margin. Recurrence and/or de novo development of KOT were assessed. Gene analysis using peripheral blood was performed in all patients to identify the mutation of PTCH1 gene...
January 29, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29373110/gorlin-syndrome
#15
I Palacios-Álvarez, R González-Sarmiento, E Fernández-López
Gorlin syndrome is a rare autosomal dominant disease caused by mutations in the sonic hedgehog signaling pathway. Of particular importance is the PTCH1 gene. The disease is characterized by the development of multiple basal cell carcinomas at young ages. These tumors may present with other skin manifestations such as palmoplantar pits and with extracutaneous manifestations such as odontogenic keratocysts and medulloblastoma. Although the dermatologist may be key for recognizing clinical suspicion of the syndrome, a multidisciplinary team is usually necessary for diagnosis, treatment, and follow-up...
April 2018: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29354003/diffusion-weighted-mr-imaging-of-unicystic-odontogenic-tumors-for-differentiation-of-unicystic-ameloblastomas-from-keratocystic-odontogenic-tumors
#16
Yifeng Han, Xindong Fan, Lixin Su, Zhenfeng Wang
Objective: Differentiating unicystic ameloblastomas from keratocystic odontogenic tumors (KCOT) is necessary for the planning of different treatment strategies; however, it is difficult based on conventional CT and MR sequences alone. The purpose of this study was to investigate the utility of diffusion-weighted imaging (DWI) and apparent diffusion coefficients (ADCs) in the differentiation of the two tumors. Materials and Methods: We prospectively studied 40 patients with odontogenic cysts and tumors of the maxillomandibular region using conventional MR imaging and DWI...
January 2018: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/29336289/management-of-odontogenic-cysts-by-endonasal-endoscopic-techniques-a-systematic-review-and-case-series
#17
Michael J Marino, Amber Luong, William C Yao, Martin J Citardi
BACKGROUND: Odontogenic cysts and tumors of the maxilla may be amendable to management by endonasal endoscopic techniques, which may reduce the morbidity associated with open procedures and avoid difficult reconstruction. OBJECTIVE: To perform a systematic review that evaluates the feasibility and outcomes of endoscopic techniques in the management of different odontogenic cysts. A case series of our experience with these minimally invasive techniques was assembled for insight into the technical aspects of these procedures...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29334213/conservative-management-of-ovarian-fibroma-in-a-case-of-gorlin-goltz-syndrome-comorbid-with-endometriosis
#18
Sepideh Khodaverdi, Leila Nazari, Abolfazl Mehdizadeh-Kashi, Mansoureh Vahdat, Samaneh Rokhgireh, Ali Farbod, Banafsheh Tajbakhsh
Ovarian fibromas are the most common benign solid ovarian tumors, which are often difficult to diagnose preoperatively. Ovarian fibromas, especially in bilateral cases, may be cases of Gorlin-Goltz syndrome (GGS), a rare autosomal dominant disorder with predisposition to basal cell carcinomas (BCCs) and other various benign and malignant tumors. This case report describes a 25 year-old female with GGS, bilateral ovarian fibroma, endometriosis and septated uterus, which was referred to the Gynecology Clinic of Rasoul-e-Akram Hospital in October 2016...
April 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29279565/the-effects-of-marsupialization-on-bone-regeneration-adjacent-to-keratocystic-odontogenic-tumors-and-the-mechanisms-involved
#19
Xiang Hu, Yi Zhao, Qi-Wen Man, Rui-Fang Li, Bing Liu, Yi-Fang Zhao
Bone resorption in the jaws is one of the most severe complications of keratocystic odontogenic tumors (KCOTs), and can be treated by either enucleation or marsupialization. However, the effects of marsupialization on bone regeneration adjacent to KCOTs, and the mechanisms involved, are still unclear. In this study, samples of 27 KCOTs were collected (20 before marsupialization and 7 after marsupialization) to detect the expression of bone regeneration-related molecules adjacent to KCOTs by immunohistochemistry and real-time quantitative polymerase chain reaction (qPCR)...
2017: Journal of Oral Science
https://www.readbyqxmd.com/read/29233700/volumetric-analysis-of-keratocystic-odontogenic-tumors-and-non-neoplastic-jaw-cysts-comparison-and-its-clinical-relevance
#20
Martin Kauke, Ali-Farid Safi, Andrea Grandoch, Hans-Joachim Nickenig, Joachim Zöller, Matthias Kreppel
The keratocystic odontogenic tumor (KCOT) is capable of causing vast osseous destruction. Histopathological examination is pivotal for diagnosis. The diagnostic process can sometimes be hindered by tissue inflammation of KCOTs with loss of defining criteria, resulting in misdiagnosis as an odontogenic jaw cyst. We discuss the possible merits of volumetric analysis when facing this particular diagnostic dilemma and for pathophysiological characterization of KCOTs. We included 114 patients, of whom 27 were histopathologically diagnosed with a KCOT and 87 with dentigerous (n = 41) and periapical cyst (n = 46)...
February 2018: Journal of Cranio-maxillo-facial Surgery
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