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Keratocystic odontogenic tumor

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https://www.readbyqxmd.com/read/28650783/conservative-treatment-of-multiple-keratocystic-odontogenic-tumors-in-a-young-patient-with-nevoid-basal-cell-carcinoma-syndrome-by-decompression-a-7-year-follow-up-study
#1
Su-Hyun Kim, Min-Seok Oh, Yo-Seob Seo, Jin-Young Kim, Soon-Hyeun Nam, Su-Min Lim
Multiple keratocystic odontogenic tumors (KCOT) occurred in a young child is challenging problem in the field of pediatric dentistry, and might have been related to nevoid basal cell carcinoma syndrome (NBCCS). Because of high recurrence rate of KCOTs, complete surgical resection is generally accepted as definitive treatment. However, complete surgical resection could induce negative effect on the development of permanent teeth and growth of jaw. Herein, we reported successful treatment case of young KCOT patient with NBCCS...
2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28635992/odontogenic-tumors-a-retrospective-clinicopathological-study-from-two-italian-centers
#2
C Rubini, M Mascitti, A Santarelli, A Tempesta, L Limongelli, G Favia, E Maiorano
Objective: The aim of this retrospective study was to perform an epidemiological analysis of all odontogenic tumors treated in the University Hospitals "Ospedali Riuniti" in Ancona and "Policlinico" in Bari, from 1990 to 2015. Materials and methods: A retrospective survey of 277 patients treated for odontogenic tumors from 1990 to 2015 was performed. Data were retrieved from the archives of the above quoted Sections of Pathology. The lesions were classified according to 2005 WHO histological classification, and the following variables were analyzed: age, sex, histopathological diagnosis, site distribution, tumor size, and relapses...
March 2017: Pathologica
https://www.readbyqxmd.com/read/28611319/assessing-alpha-tocopherol-levels-in-patients-with-keratocystic-odontogenic-tumor-a-cross-sectional-study
#3
Bhargavi Krishna Ayinampudi, Sushmita Bhargavi Varikoti, Pacha Venkat Baghirath, B Hari Vinay, Ch Gayathri, Ashalata Gannepalli
AIMS AND OBJECTIVES: A keratocystic odontogenic tumour (KCOT) is a benign uni- or multicystic, intraosseous tumour of odontogenic origin, with a characteristic lining of parakeratinized stratified squamous epithelium and potential for aggressive, infiltrative behaviour. Various studies in hamsters showed that, alpha-Tocopherol, which is an active biological form of Vitamin E, is a potent antioxidant known to inhibit tumour formation and also regression of established tumours. So, the aim of the present pilot study was to assess the levels of Alpha-Tocopherol(Vitamin E) in Patients with KCOT and compare them with Vitamin E levels in normal healthy individuals...
March 2017: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28584604/p53-protein-expression-in-dental-follicle-dentigerous-cyst-odontogenic-keratocyst-and-inflammatory-subtypes-of-cysts-an-immunohistochemical-study
#4
Mashhadiabbas Fatemeh, Arab Sepideh, Bagheri Seyedeh Sara, Mahdavi Nazanin
OBJECTIVES: An odontogenic keratocyst (OKC) is a developmental odontogenic cyst with aggressive clinical behavior. This cyst shows a different growth mechanism from the more common dentigerous cyst and now has been renamed as a keratocystic odontogenic tumor (KCOT). Inflammation can assist tumor growth via different mechanisms including dysregulation of the p53 gene. This study aims to assess and compare the expression of tumor suppressor gene p53 in inflamed and non-inflamed types of OKC and dentigerous cyst...
May 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/28521454/histopathological-and-immunohistochemical-study-in-keratocystic-odontogenic-tumors-predictive-factors-of-recurrence
#5
Tomofumi Naruse, Kentaro Yamashita, Souichi Yanamoto, Satoshi Rokutanda, Yuki Matsushita, Yuki Sakamoto, Hiroshi Sakamoto, Hisazumi Ikeda, Tohru Ikeda, Izumi Asahina, Masahiro Umeda
The aim of the present study was to identify the most useful markers for predicting recurrence of keratocystic odontogenic tumors (KCOTs). A total of 65 tumor samples from 63 patients diagnosed with typical parakeratinized cysts and KCOTs between 1992 and 2014 were retrospectively studied. Clinical and histopathological data and treatment modality were reviewed. In addition, the expression profiles of Ki-67, cluster of differentiation (CD)34 and podoplanin were assessed using immunohistochemistry. The association between these factors and the rate of KCOT recurrence was evaluated...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28512636/expression-of-yap-taz-in-keratocystic-odontogenic-tumors-and-its-possible-association-with-proliferative-behavior
#6
Qi-Wen Man, Yan-Qi Ma, Jin-Yuan Liu, Yi Zhao, Bing Liu, Yi-Fang Zhao
The aim of this study is to clarify whether YAP/TAZ is involved in the pathogenesis and proliferative growth of keratocystic odontogenic tumor (KCOT). The expression levels of YAP/TAZ and downstream proteins and genes in normal oral mucosa (OM) and KCOT were determined and compared by immunohistochemistry and real-time quantitative PCR. The results showed that the expression of YAP/TAZ and downstream proteins (Cyr61, CTGF) was significantly upregulated in KCOT with upregulation of Ki-67 compared to OM. Importantly, the mRNA levels of transcription factors (TEAD1, TEAD4, and RUNX2) and cell cycle related genes (CDK2, PCNA), which interact with the transcriptional coactivators YAP/TAZ, are also upregulated in the KCOT...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28499501/potential-involvement-of-chondroitin-sulfate-a-in-the-pathogenesis-of-ameloblastoma
#7
Xiangjun Li, Hiroshi Kurita, Tiepeng Xiao, Kyou Iijima, Kenji Kurashina, Jun Nakayama
Ameloblastoma is classified as a benign odontogenic tumor characterized by locally invasive behavior and high risk of recurrence. Here, we evaluate a potential role for glycosaminoglycan, a structural component of cell membranes and extracellular matrix, in ameloblstoma pathogenesis. We subjected formalin-fixed, paraffin-embedded tissue sections of 34 cases of ameloblastoma, 10 of odontogenic keratocyst, and 17 of dentigerous cyst to immunohistochemistry using monoclonal antibodies recognizing chondroitin sulfate A (CS-A), heparan sulfate (HS), and keratan sulfate (KS)...
May 9, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28489118/analysis-of-glut-1-glut-3-and-angiogenic-index-in-syndromic-and-non-syndromic-keratocystic-odontogenic-tumors
#8
Rafaella Bastos Leite, Roberta Barroso Cavalcante, Renato Luiz Maia Nogueira, Lélia Batista de Souza, Leão Pereira Pinto, Cassiano Francisco Weege Nonaka
The aim of this study was to evaluate the immunoexpression of glucose transporters 1 (GLUT-1) and 3 (GLUT-3) in keratocystic odontogenic tumors associated with Gorlin syndrome (SKOTs) and non-syndromic keratocystic odontogenic tumors (NSKOTs), and to establish correlations with the angiogenic index. Seventeen primary NSKOTs, seven recurrent NSKOTs, and 17 SKOTs were selected for the study. The percentage of immunopositive cells for GLUT-1 and GLUT-3 in the epithelial component of the tumors was assessed. The angiogenic index was determined by microvessel count...
April 27, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28479710/squamous-cell-carcinoma-arising-from-keratocystic-odontogenic-tumor
#9
Supriya Kheur, G S Mamatha, Neeta Bagul, Kapil Kshirsagar
No abstract text is available yet for this article.
January 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28479687/comparative-immunohistochemical-study-of-bcl-x-in-ameloblastoma-keratocystic-odontogenic-tumor-and-adenomatoid-odontogenic-tumor
#10
Payal Shukla, Sudeendra Prabhu, Maji Jose, B H Sripathi Rao
OBJECTIVES: Since its recognition as a physiologic process associated with tumor, among molecular mechanisms involved in tumor progression, defects in regulation of apoptosis have generated an accelerating volume of research that has sought to elucidate the role of programed cell death in pathogenesis and treatment of various tumors. Therefore, this study was performed to understand better the diverse biological profile of epithelial odontogenic tumors with the help of immunohistochemical expression of Bcl-X protein...
January 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28471735/clinical-finding-and-management-of-12-orofacial-clefts-cases-with-nevoid-basal-cell-carcinoma-syndrome
#11
Lee Mui Lee, Lian Ma, Tie Jun Li
Objective  To study the phenotype and overview the clinical management on Cleft Lip and/or Palate (CL/P) with Nevoid Basal Cell Carcinoma Syndrome (NBCCS) patients in Peking University School and Hospital of Stomatology. Design  Case series study. Main Outcome Measures  To describe the clinical phenotype of 12 CL/P with NBCCS patients who fulfilled the diagnostic criteria as well as to explore clinical management. Results  Seven cases (7/12, 58.33%) were classified as bilateral complete cleft lip and palate (BCCLP)...
May 2017: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/28460843/interest-of-decompression-in-orthodontics-case-report-of-a-keratocyst-during-childhood
#12
Alexandre Alpy, Laurianne Tournaire, Fréderic Vaysse, Christine Marchal-Sixou, Arnaud Lhomme, Bruno Courtois
Keratocysts, also known as keratocystic odontogenic tumors (KCOT), make up 7% of all odontogenic cysts and develop asymptomatically in most cases. Enucleation is the benchmark treatment. However, there are surgical alternatives. Marsupialization and decompression are necessary in some cases, mainly when the KCOT is large, thus causing an increased risk of bone fracture, or if it has engulfed important elements such as the inferior alveolar nerve or teeth, consequently causing alveolar bone growth failure. The authors describe the case of a nine-year-old child treated for a large keratocyst situated in sector 4 (lower right jaw), impacting both premolars and the canine (45, 44 and 43)...
April 28, 2017: International Orthodontics
https://www.readbyqxmd.com/read/28449413/sporadic-versus-syndromic-keratocysts-can-we-predict-treatment-outcome-a-review-of-102-cysts
#13
Dani Noy, Adi Rachmiel, Keidar Zar, Omri Emodi, Rafael M Nagler
OBJECTIVES: Keratocystic odontogenic tumor (KCOT) demonstrates variable growth mechanisms and biologic behavior, partly due to origin and histology. We looked for the most contributing factors in predicting outcome of treatment. SUBJECTS AND METHODS: We retrospectively reviewed 118 medical files of patients diagnosed with KCOT (by tissue biopsy before surgical treatment) with/without nevoid basal cell carcinoma syndrome (NBCCS) from 1995 to 2015. Data were recorded and analyzed statistically to determine the treatment-outcome correlation...
April 27, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28446856/big-keratocystic-odontogenic-tumor-of-the-mandible-a-case-report
#14
Bruktawit Kebede, Demerew Dejene, Abebe Teka, Biruk Girma, Evelyn Perez Aguirre, Noel Emigdio Perez Guerra
BACKGROUND: Keratocystic odontogenic tumor (KCOT) is a rare, benign, intraosseous tumor of odontogenic origin with a potential of aggressive and infiltrative behavior. It shows specific histopathological features, and has a high recurrence rate. CASE DETAILS: The presented case was of a 30 years old man from South Ethiopia, with a giant keratocystic odontogenic tumor of the mandible. CONCLUSIONS: Although the occurrence of KCOT is rare, attention should be given during its clinical diagnosis...
September 2016: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/28390759/tube-decompression-for-staged-treatment-of-a-calcifying-odontogenic-cyst-a-case-report
#15
Hany A Emam, Judson Smith, Ashleigh Briody, Courtney A Jatana
The calcifying odontogenic cyst is a rare developmental odontogenic lesion with a distinguishing cystic lining containing "ghost" epithelial cells. The variation in clinical, radiographic, and histologic findings makes the treatment decision difficult for these lesions. There are very few reports on treatment, with enucleation and curettage being the standard surgical method of choice for the cystic type and excision of the tumor for the solid type. A 2-stage surgical approach consisting of initial decompression with tube placement followed by a secondary procedure of enucleation and curettage is common for other large odontogenic cysts, such as dentigerous and odontogenic keratocysts...
March 18, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28377093/decompression-of-keratocystic-odontogenic-tumors-leading-to-increased-fibrosis-but-without-any-change-in-epithelial-proliferation
#16
Sarah Awni, Brendan Conn
OBJECTIVE: The aim of this study was to investigate whether decompression treatment induces changes in the histology or biologic behavior of keratocystic odontogenic tumor (KCOT). STUDY DESIGN: Seventeen patients with KCOT underwent decompression treatment with or without enucleation. Histologic evaluation and immunohistochemical expression of p53, Ki-67, and Bcl-2 were analyzed by using conventional microscopy. RESULTS: KCOT showed significantly increased fibrosis (P = ...
December 30, 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28341089/corrigendum-to-malignant-transformation-of-keratocystic-odontogenic-tumor-two-case-reports-american-journal-of-otolaryngology-34-2013-357-361
#17
Bernard Tan, Sok Yan Tay, Lee Shermin, Kwa Chong Teck, Poon Choy Yoke, Christopher Goh, Abhilash Balakrishnan
No abstract text is available yet for this article.
March 21, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28316917/a-comparative-study-of-syndecan-1-expression-in-different-odontogenic-tumors
#18
Shahroo Etemad-Moghadam, Mojgan Alaeddini
BACKGROUND: Expression of various cellular/molecular factors change during the course of tumor formation from odontogenic tissues of the tooth germ. Evaluation of these factors can help provide a better perception of the tumorigenesis and biologic behavior of odontogenic tumors (OTs). Syndecan-1 is a heparan sulfate proteoglycan which has not been extensively investigated in these lesions. The objective of the present study was to assess the immunohistochemical expression of CD138 in adenomatoid odontogenic tumor (AOT), ameloblastic fibroma (AF) and odontogenic myxoma (OM) and to compare it with ameloblastoma and keratocystic odontogenic tumor (KCOT)...
January 2017: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/28273221/keratocystic-odontogenic-tumor
#19
Brenda DE Souza Moura, Maria Aparecida Cavalcante, Wagner Hespanhol
to evaluate the frequency of keratocystic odontogenic tumor (KOT) in the Oral Surgery Service (OSS) of the University Hospital Clementino Fraga Filho of the Federal University of Rio de Janeiro (HUCFF / UFRJ), with respect to recurrence rate, gender, age of recurrence and location of the injury Methods: clinical records were reviewed and histopathological reports of KOT patients of the HUCFF/UFRJ between 2002 and 2012. Patients diagnosed with KOT were divided into two groups for the occurrence of relapse: positive (n=6) and negative (n=19) Results: regarding the location, there was a predilection for the mandible...
December 2016: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28238093/role-of-hif-1%C3%AE-and-caspase-3-in-cystogenesis-of-odontogenic-cysts-and-tumors
#20
Natacha M M da Costa, Adriane S de Siqueira, André L R Ribeiro, Maria S da Silva Kataoka, Ruy G Jaeger, Sérgio M de Alves-Júnior, Andrew M Smith, João de Jesus Viana Pinheiro
OBJECTIVES: Odontogenic cysts and tumors are the most relevant lesions that affect the gnathic bones. These lesions have in common the formation of cystic areas and this common feature may suggest involvement of similar mechanisms. The hypoxia inducible factor 1 alpha (HIF-1α), a responsive protein to hypoxia and caspase-3, an irreversible apoptosis marker, may contribute to cyst formation. Thus, this study aimed to investigate the immunoexpression of these proteins in odontogenic cysts and tumors...
February 25, 2017: Clinical Oral Investigations
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