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Keratocystic odontogenic tumor

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https://www.readbyqxmd.com/read/28390759/tube-decompression-for-staged-treatment-of-a-calcifying-odontogenic-cyst-a-case-report
#1
Hany A Emam, Judson Smith, Ashleigh Briody, Courtney A Jatana
The calcifying odontogenic cyst is a rare developmental odontogenic lesion with a distinguishing cystic lining containing "ghost" epithelial cells. The variation in clinical, radiographic, and histologic findings makes the treatment decision difficult for these lesions. There are very few reports on treatment, with enucleation and curettage being the standard surgical method of choice for the cystic type and excision of the tumor for the solid type. A 2-stage surgical approach consisting of initial decompression with tube placement followed by a secondary procedure of enucleation and curettage is common for other large odontogenic cysts, such as dentigerous and odontogenic keratocysts...
March 18, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28377093/decompression-of-keratocystic-odontogenic-tumors-leading-to-increased-fibrosis-but-without-any-change-in-epithelial-proliferation
#2
Sarah Awni, Brendan Conn
OBJECTIVE: The aim of this study was to investigate whether decompression treatment induces changes in the histology or biologic behavior of keratocystic odontogenic tumor (KCOT). STUDY DESIGN: Seventeen patients with KCOT underwent decompression treatment with or without enucleation. Histologic evaluation and immunohistochemical expression of p53, Ki-67, and Bcl-2 were analyzed by using conventional microscopy. RESULTS: KCOT showed significantly increased fibrosis (P = ...
December 30, 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28341089/corrigendum-to-malignant-transformation-of-keratocystic-odontogenic-tumor-two-case-reports-american-journal-of-otolaryngology-34-2013-357-361
#3
Bernard Tan, Sok Yan Tay, Lee Shermin, Kwa Chong Teck, Poon Choy Yoke, Christopher Goh, Abhilash Balakrishnan
No abstract text is available yet for this article.
March 21, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28316917/a-comparative-study-of-syndecan-1-expression-in-different-odontogenic-tumors
#4
Shahroo Etemad-Moghadam, Mojgan Alaeddini
BACKGROUND: Expression of various cellular/molecular factors change during the course of tumor formation from odontogenic tissues of the tooth germ. Evaluation of these factors can help provide a better perception of the tumorigenesis and biologic behavior of odontogenic tumors (OTs). Syndecan-1 is a heparan sulfate proteoglycan which has not been extensively investigated in these lesions. The objective of the present study was to assess the immunohistochemical expression of CD138 in adenomatoid odontogenic tumor (AOT), ameloblastic fibroma (AF) and odontogenic myxoma (OM) and to compare it with ameloblastoma and keratocystic odontogenic tumor (KCOT)...
January 2017: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/28273221/keratocystic-odontogenic-tumor
#5
Brenda DE Souza Moura, Maria Aparecida Cavalcante, Wagner Hespanhol
to evaluate the frequency of keratocystic odontogenic tumor (KOT) in the Oral Surgery Service (OSS) of the University Hospital Clementino Fraga Filho of the Federal University of Rio de Janeiro (HUCFF / UFRJ), with respect to recurrence rate, gender, age of recurrence and location of the injury Methods: clinical records were reviewed and histopathological reports of KOT patients of the HUCFF/UFRJ between 2002 and 2012. Patients diagnosed with KOT were divided into two groups for the occurrence of relapse: positive (n=6) and negative (n=19) Results: regarding the location, there was a predilection for the mandible...
December 2016: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28238093/role-of-hif-1%C3%AE-and-caspase-3-in-cystogenesis-of-odontogenic-cysts-and-tumors
#6
Natacha M M da Costa, Adriane S de Siqueira, André L R Ribeiro, Maria S da Silva Kataoka, Ruy G Jaeger, Sérgio M de Alves-Júnior, Andrew M Smith, João de Jesus Viana Pinheiro
OBJECTIVES: Odontogenic cysts and tumors are the most relevant lesions that affect the gnathic bones. These lesions have in common the formation of cystic areas and this common feature may suggest involvement of similar mechanisms. The hypoxia inducible factor 1 alpha (HIF-1α), a responsive protein to hypoxia and caspase-3, an irreversible apoptosis marker, may contribute to cyst formation. Thus, this study aimed to investigate the immunoexpression of these proteins in odontogenic cysts and tumors...
February 25, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28222389/correlation-between-ploidy-status-using-flow-cytometry-and-nucleolar-organizer-regions-in-benign-and-malignant-epithelial-odontogenic-tumors
#7
Sarah Ahmed Mohamed Mahmoud, Dalia Hussein El-Rouby, Safa Fathy Abd El-Ghani, Omnia Mohamed Badawy
OBJECTIVE: Differentiation between the aggressive benign odontogenic tumors and their malignant counterparts is controversial and difficult. While flow cytometry (FCM) allowed DNA analysis in neoplasia, argyrophilic organizer regions (AgNORs) number and/or size in a nucleus are correlated with the ribosomal gene activity and therefore with cellular proliferation. The aim of this research was to study the diagnostic accuracy of FCM and AgNORs staining in differentiating between benign and malignant epithelial odontogenic tumors and to correlate between these two interventions...
February 14, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28199753/tnf-%C3%AE-308g-a-and-tnf-r1-36a-g-single-nucleotide-polymorphisms-are-strong-risk-factors-for-odontogenic-keratocystic-tumor-development
#8
Branislav Ilic, Nadja Nikolic, Miroslav Andric, Drago Jelovac, Biljana Milicic, Tanja Jozic, Slobodan Krstic, Jelena Milasin
BACKGROUND: Polymorphisms in genes encoding tumor necrosis factor-α (TNF-α) and its receptor TNF-R1 have been shown to affect one person's susceptibility to develop certain neoplastic diseases. The aim of the present association study was to investigate whether single nucleotide polymorphisms (SNPs) in TNF-α (-308G>A) and TNF-R1 (36A>G) genes modulate the susceptibility for keratocystic odontogenic tumors (KCOTs) development in Serbian patients. METHODS: Genotyping was performed in 60 KCOT patients and 125 healthy individuals, using polymerase chain reaction/restriction fragment length polymorphism analysis...
April 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28187891/automated-classification-of-maxillofacial-cysts-in-cone-beam-ct-images-using-contourlet-transformation-and-spherical-harmonics
#9
Fatemeh Abdolali, Reza Aghaeizadeh Zoroofi, Yoshito Otake, Yoshinobu Sato
BACKGROUND AND OBJECTIVE: Accurate detection of maxillofacial cysts is an essential step for diagnosis, monitoring and planning therapeutic intervention. Cysts can be of various sizes and shapes and existing detection methods lead to poor results. Customizing automatic detection systems to gain sufficient accuracy in clinical practice is highly challenging. For this purpose, integrating the engineering knowledge in efficient feature extraction is essential. METHODS: This paper presents a novel framework for maxillofacial cysts detection...
February 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28174367/collagen-and-its-role-in-predicting-the-biological-behavior-of-odontogenic-lesions
#10
Pavan G Kulkarni, M Aruna Kumari, Abhishek Jahagirdar, Srk Nandan, Shyam Prasad Reddy D, M Keerthi
INTRODUCTION: Odontogenic cysts and tumors have variable recurrence rates. Recurrence rate is mainly due to the activity of the epithelium. The epithelium of these lesions has been investigated extensively in regard to their role in proliferative and aggressive behavior of the lesions. However, the role of the connective tissue wall in their behavior has not been studied as extensively. Collagen is an essential part of the connective tissue as a whole and fibrous wall of cystic lesions especially...
February 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28160576/the-relative-frequency-of-odontogenic-tumors-a-study-of-376-cases-in-a-brazilian-population
#11
R Lima-Verde-Osterne, E Turatti, R Cordeiro-Teixeira, R Barroso-Cavalcante
BACKGROUND: Odontogenic tumors (OTs) are rare lesions, exclusive of the jaws, that are derived from epithelial and/or ectomesenchymal elements of the tooth-forming apparatus. Their biological behavior is heterogeneous, including hamartomatous tissue proliferation, benign nonaggressive and aggressive neoplasms, and malignant tumors with metastatic capacity. The aim of this study was to describe the relative frequency of odontogenic tumors in a Brazilian population. In addition, a review of the literature identified studies on odontogenic tumors that follow the 2005 World Health Organization...
March 1, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28153133/odontogenic-cysts-and-neoplasms
#12
REVIEW
Elizabeth Ann Bilodeau, Bobby M Collins
This article reviews a myriad of common and uncommon odontogenic cysts and tumors. The clinical presentation, gross and microscopic features, differential diagnosis, prognosis, and diagnostic pitfalls are addressed for inflammatory cysts (periapical cyst, mandibular infected buccal cyst/paradental cyst), developmental cysts (dentigerous, lateral periodontal, glandular odontogenic, orthokeratinized odontogenic cyst), benign tumors (keratocystic odontogenic tumor, ameloblastoma, adenomatoid odontogenic tumor, calcifying epithelial odontogenic tumor, ameloblastic fibroma and fibroodontoma, odontoma, squamous odontogenic tumor, calcifying cystic odontogenic tumor, primordial odontogenic tumor, central odontogenic fibroma, and odontogenic myxomas), and malignant tumors (clear cell odontogenic carcinoma, ameloblastic carcinoma, ameloblastic fibrosarcoma)...
March 2017: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/28149484/maxillary-peripheral-keratocystic-odontogenic-tumor-a-clinical-case-report
#13
María Del Carmen Vázquez-Romero, María de Los Angeles Serrera-Figallo, Javier Alberdi-Navarro, Javier Cabezas-Talavero, Manuel-María Romero-Ruiz, Daniel Torres-Lagares, Jose-Manuel Aguirre-Urizar, Jose-Luis Gutiérrez-Pérez
The keratocystic odontogenic tumor is a benign odontogenic cystic neoplasia characterized by its thin, squamous epithelium with superficial parakeratosis. It has the potential for infiltration and local aggressiveness and has a high rate of recurrence. This neoplasia is predominantly found in males and people of white origin. The mandible is the most frequently involved site, in particular the third molar region, mandibular angle, and ramus. It has a mandible-maxilla ratio of 2:1. Only about twenty cases of peripheral keratocystic odontogenic tumors (PKCOT) have been reported in the international literature...
January 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28099232/keratocystic-odontogenic-tumor-involving-the-orbital-apex
#14
Adam R Sweeney, Jasjit K Dillon, Christopher B Chambers
No abstract text is available yet for this article.
January 17, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28089087/prevalence-profile-of-odontogenic-cysts-and-tumors-on-brazilian-sample-after-the-reclassification-of-odontogenic-keratocyst
#15
Filipe Jaeger, Mariana Saturnino de Noronha, Maiza Luiza Vieira Silva, Márcio Bruno Figueiredo Amaral, Soraya de Mattos Carmago Grossmann, Martinho Campolina Rebello Horta, Paulo Eduardo Alencar de Souza, Maria Cássia Ferreira de Aguiar, Ricardo Alves Mesquita
PURPOSE: The aim of this study was to evaluate the impact of the reclassification of odontogenic keratocyst (OKC) as a tumor on the prevalence profile of odontogenic cysts (OCs) and odontogenic tumors (OTs). STUDY DESIGN: Two referral Oral and Maxillofacial Pathology services in Brazil were evaluated. All cases diagnosed as OCs or OTs were selected and classified according to the 1992 WHO-classification (cases before 2005 WHO classification of tumors excluding OKC) and the 2005 WHO classification of tumors, going forward including cases of odontogenic keratocyst tumor (KCOT)...
December 18, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28060370/diagnosing-the-most-common-odontogenic-cystic-and-osseous-lesions-of-the-jaws-for-the-practicing-pathologist
#16
Robert A Robinson
Odontogenic cysts and osseous lesions are often seen as challenging diagnostic lesions but the majority of them are easily classified. This article outlines the diagnostic features required for separating the most common of odontogenic cysts and select osseous lesions of the jaws. Clinical and radiographic findings of these jaw lesions often lead to a differential diagnosis that only the histologic findings will clarify. Dentigerous cyst, keratocystic odontogenic tumor, and certain ameloblastomas that have cystic change, may have identical radiographic findings, with only separation by their specific histologic features leading to the significantly different treatments required for each...
January 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28054463/kallikrein-related-peptidase-expression-in-odontogenic-cysts-and-tumors-an-immunohistochemical-comparative-study
#17
Mark Roger Darling, Rebecca Woodford, Karl Kevin Cuddy, Linda Jackson-Boeters, Alyssa Hayter, Jeyanth Inkaran, Eleftherios P Diamandis, Zia Khan
AIM: The aim of the present study was to profile the expression of human kallikrein (KLK)-related peptidases (KLK) in odontogenic lesions. METHODS: Paraffin-embedded, formalin-fixed, non-odontogenic (control) and odontogenic lesions were stained for KLK using a standard immunohistochemical technique. The intensity and proportion of epithelial cells stained was scored. Reverse transcription-polymerase chain reaction was utilized to evaluate KLK 1-15 mRNA expression in ameloblastomas...
January 4, 2017: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/28025428/expression-of-p73-and-trail-in-odontogenic-cysts-and-tumors
#18
Marco Mascitti, Andrea Santarelli, Antonio Zizzi, Maurizio Procaccini, Lorenzo Lo Muzio, Corrado Rubini
Odontogenic tumors are a group of lesions arising from the odontogenic apparatus. Although the mechanism of oncogenesis and tumor progression in these lesions remains unknown, certain proteins, such as those involved in apoptosis, seem to be involved in the differentiation and proliferation of odontogenic epithelial cells. The aim of this study was to analyze the expression of p73 and TNF-related apoptosis-inducing ligand (TRAIL) in odontogenic tumors and cysts, and to clarify changes in the expression of these proteins...
2016: Journal of Oral Science
https://www.readbyqxmd.com/read/28011178/recurrence-probability-for-keratocystic-odontogenic-tumors-an-analysis-of-6427-cases
#19
Bruno Ramos Chrcanovic, Ricardo Santiago Gomez
PURPOSE: To investigate and compare the probability of recurrence of keratocystic odontogenic tumors (KCOTs) for different variables and treatment protocols. MATERIALS AND METHODS: An electronic search was undertaken in April 2016 that included clinical series of KCOTs reporting recurrences. Untransformed proportions and meta-analyses were performed to estimate the probability/risk of recurrence, according to several variables. RESULTS: A total of 94 publications were included (6427 KCOTs, 1464 recurrences)...
November 19, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/27957261/p53-p63-and-p73-expression-and-angiogenesis-in-keratocystic-odontogenic-tumors
#20
Soranun Chandrangsu, Kraisorn Sappayatosok
BACKGROUND: Keratocystic odontogenic tumors (KCOTSs) are odontogenic tumors previously referred to as odontogenic keratocysts. Several studies have reported that KCOT behavior is more like that of a benign neoplasm than a cyst. KCOTs are locally destructive and exhibit a high recurrence rate. The objective of this study is to characterize the expression of p53, p63 and p73 in KCOTs together with the relationship between their expression and KCOT angiogenesis and recurrence. MATERIAL AND METHODS: Standard indirect immunohistochemistry using monoclonal antibodies specific to human p53, p63, p73 and CD105 was performed in formalin-fixed paraffin-embedded tissue sections of 39 KCOT samples...
December 2016: Journal of Clinical and Experimental Dentistry
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