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Sedigheh Rahrotaban, Nariman Nikparto, Parham Yousefizadeh, Mohammad Javad Kharazifard, Samira Derakhshan
OBJECTIVE: The purpose of this study was to assess and compare fascin expression in 4 lesions which differ in aggressiveness: odontogenic keratocyst, dentigerous cyst and two types of ameloblastoma (solid and unicystic), and to find out whether fascin expression is associated with aggressiveness of these lesions or not. MATERIAL AND METHOD: Nine solid ameloblastomas , 12 unicystic ameloblastomas, 13 odontogenic keratocyst and 12 dentigerous cyst were assessed in this study...
June 21, 2018: Türk Patoloji Dergisi
Gholamreza Jahanshahi, Elham Arzhang, Soheila Derisavy, Laleh Davoodi, Salman Shakeri
Ameloblastoma is a locally invasive tumor derived from odontogenic epithelium. An uncommon variant of ameloblastoma is granular cell type, which cannot distinguish from other ameloblastoma subtypes by clinical and radiographic findings alone. Only review of it's microscopic features allows distinction from other subtypes. The purpose of this article is to present a case of granular cell ameloblastoma. This subtype should be distinguished from the other histopathologic subtypes because of it's higher recurrence rate and more aggressive biological behavior...
May 2018: Dental Research Journal
Z Gómez-Herrera, N Molina-Frechero, P Damián-Matsumura, R González-González, J E Farfán-Morales, R Bologna-Molina
Alterations in cellular and extracellular matrix components play an important role during tumorigenesis; proteoglycans are included among these components. Ameloblastomas are odontogenic tumors distinguished as invasive and infiltrative neoplasms and are divided into different histological types, the most common of which are the unicystic ameloblastoma and the conventional ameloblastoma. The aim of this study was to identify the presence of two proteoglycans, perlecan and biglycan, in different types of ameloblastoma...
May 2018: Journal of Biological Regulators and Homeostatic Agents
Bhavana Gupta, Shaleen Chandra, Vineet Raj, Vivek Gupta
Background: The nucleolar organizer region (NOR) is by definition part of a chromosome, and nucleolus is a structure containing this chromosomal part and in addition the material which accumulate around the NOR, mostly rRNAs and their precursors as well as specific ribosomal proteins. Argyrophilic Nucleolar organizing region (AgNOR) are silver binding NORs often used to study cell proliferation in various types of tumors. Aim: Quantitative assessment of Argyrophilic Nucleolar organizing region count and its comparison among dentigerous cyst, keratocystic odontogenic tumor and ameloblastoma...
May 2018: Journal of Oral Biology and Craniofacial Research
Syeda Sara Tajammul, Usman Ali, Faiza Kazi, Hassan Mahmood
Ameloblastic carcinoma (AC) is a very rare odontogenic malignancy. Primary AC is more common in maxilla, while secondary AC is more common in mandible. Histologically, it is an ameloblastoma with features of cancer. Presence of metastasis is not necessary to establish the diagnosis. This tumor usually metastasises in bone or lungs. We report a case of aggressive secondary AC of mandible with lung metastasis. There are few cases in medical literature discussing management of AC with lung metastasis. In this case, a 42-year woman, who was diagnosed with ameloblastoma of right mandible, was treated with right hemi-mandibulectomy...
June 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Bogahawatte Samarakoon Mudiyanselage Samadarani Siriwardena, Tennakoon Mudiyanselage Priyanka Bandara Tennakoon, Keith David Hunter, Wanninayake Mudiyanselage Tilakaratne
BACKGROUND: Unicystic ameloblastoma (UA) is a variant of ameloblastoma that has a relatively benign biologic behavior and mostly occurs in a younger age group. The entire cystic lining of unicystic ameloblastoma may not always be uniformly characteristic and may partly consist of non-specific epithelium or dentigerous cyst-like lining. The variability seen reinforces the advice that multiple biopsies should be taken from large cystic lesions in order to represent the entire lesion. METHODS: All cases were retrieved from the archives of our unit from 1986 to 2016...
June 2, 2018: Journal of Oral Pathology & Medicine
Ramón G Carreón-Burciaga, Rogelio González-González, Nelly Molina-Frechero, Sandra López-Verdín, Vanesa Pereira-Prado, Ronell Bologna-Molina
Ameloblastomas are a group of benign, locally aggressive, recurrent tumors characterized by their slow and infiltrative growth. E-Cadherin and syndecan-1 are cell adhesion molecules related to the behavior of various tumors, including ameloblastomas. Ninety-nine ameloblastoma samples were studied; the expression of E-cadherin and syndecan-1 were evaluated by immunohistochemistry. E-Cadherin and epithelial syndecan-1 were more highly expressed in intraluminal/luminal unicystic ameloblastoma than in mural unicystic ameloblastoma and solid/multicystic ameloblastoma, whereas the stromal expression of syndecan-1 was higher in mural unicystic ameloblastoma and solid/multicystic ameloblastoma...
2018: Analytical Cellular Pathology (Amsterdam)
Benjamin G Barrena, Billy J Phillips, Kenneth J Moran, Sasha J Betz
Ameloblastomas are benign but aggressive odontogenic tumors that most commonly affect the posterior mandible. Approximately 15% occur in the maxilla, with a subset thought to originate from the epithelial lining of the sinonasal cavities. Histologically, sinonasal ameloblastomas are identical to those of the oral cavity, with classical features of palisaded columnar basilar cells surrounding a central proliferation that resembles the stellate reticulum of a developing tooth. Unlike the gnathic variant, sinonasal ameloblastomas tend to affect males more than females, and the incidence of diagnosis peaks at a later age, approximately 60 years old...
May 30, 2018: Head and Neck Pathology
Delmira Apellániz, Vanesa Pereira-Prado, Estefania Sicco, Gabriela Vigil-Bastitta, Rogelio González-González, Adalberto Mosqueda-Taylor, Nelly Molina-Frechero, Marcela Hernandez, Celeste Sánchez-Romero, Ronell Bologna-Molina
INTRODUCTION: Solid/conventional ameloblastoma (AM) and unicystic ameloblastoma (UAM) are the most frequent benign epithelial odontogenic tumors located in the maxillary region, and their treatment usually consists of extensive surgical resection. Therefore, it is relevant to study molecular markers to better understand the biological behavior of these tumors. The aim of this study was to describe and compare the expression of proteins related to cellular proliferation: Ki-67 and MCM4-6 complex...
May 1, 2018: International Journal of Surgical Pathology
Safa Zakaraia, Mamdouh Almohareb, Khaled Zaid, Mazen Doumani, Mohammad Yaman Seirawan
Amelogenin (AMEL), the major structural protein of the enamel organic matrix, constitutes more than 90% of the enamel’s protein content, Aberrations of amelogenin are thought to be involved in the oncogenesis of odontogenic epithelium. The expression of amelogenin is possibly an indicator of differentiation of epithelial cells in the odontogenic tumors. Aim of the study: Investigating the expression of amelogenin in some odontogenic tumors, using an anti-amelogenin polyclonal antibody, and then compare it with AMEL expression in tooth buds as control...
May 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Daniela Adorno-Farias, Vinícius Rio Verde Melo Muniz, Amanda Pinheiro Soares, Patrícia Ramos Cury, Rosângela Góes Rabelo, Ricardo Fernández-Ramires, Roberto Almeida de Azevedo, Jean Nunes Dos Santos
BACKGROUND: Ameloblastoma with adenoid features are characterized by the presence of duct-like structures formed from the parenchyma of the tumor. This study was conducted to report a series of eight ameloblastomas with adenoid features, highlighting their clinicopathological and immunohistochemical aspects. MATERIAL AND METHODS: Out of 71 cases of ameloblastomas, this study classified 8 cases as ameloblastomas with adenoid features. Clinicopathological data and immunohistochemistry for CK7, CK14, CK19, IMP3, p53 and Ki-67 were evaluated...
May 21, 2018: Acta Histochemica
I I Babichenko, N S Tsimbalist, V F Rybal'skaya, A A Sherstnev, V A Syomkin
The aim of the study was to assess the role of the canonical Wnt/β-catenin signaling pathway in the formation and clinical course of various histological variants of ameloblastoma. MATERIAL AND METHODS: 76 cases of ameloblastoma were investigated, the average age of the patients was 46 years. There were 49 (64.5%) cases of recurrence of the disease. Tissue antigens were determined using monoclonal rabbit antibodies to Ki-67 and β-catenin. RESULTS: it was found correlation between the proliferative activity of ameloblastoma cells and the intranuclear localization of β-catenin, indicating the activation of the Wnt/β-catenin-signaling pathway...
2018: Stomatologii︠a︡
Daniel Berretta Moreira Alves, Fabrício Mesquita Tuji, Fábio Abreu Alves, André Caroli Rocha, Alan Roger Dos Santos-Silva, Pablo Agustin Vargas, Márcio Ajudarte Lopes
OBJECTIVE: The purpose of this study was to describe and compare the main imagenological features of mandibular ameloblastomas and odontogenic keratocyst (OKC) using panoramic radiograph (PR) and computed tomography (CT). METHODS: The sample consisted of 9 cases of ameloblastomas and 9 cases of OKC. PR and CT images were analyzed according to shape, internal structure, borders, associated unerupted tooth, root resorption, expansion and perforation of cortical bones...
May 23, 2018: Dento Maxillo Facial Radiology
Zinan Yang, Qian Liang, Le Yang, Guang-Sen Zheng, Si-En Zhang, Xiao-Mei Lao, Yu-Jie Liang, Gui-Qing Liao
BACKGROUND: This retrospective study investigated the reduction rate and speed of shrinkage after marsupialization in mandibular cystic ameloblastoma and clarified whether marsupialization is appropriate for unicystic ameloblastoma and multicystic ameloblastoma. METHODS: Sixty-three patients with mandibular cystic ameloblastoma were initially treated with marsupialization. Premarsupialization and postmarsupialization panoramic radiographs were reviewed for reduction rate and speed of shrinkage, and then were evaluated with age, sex, tumor location, and tumor type...
May 13, 2018: Head & Neck
Jérémie Bettoni, Cécilia Neiva, Charlie Demarteleire, Sylvie Testelin, Bernard Devauchelle, Stéphanie Dakpé
Background Ameloblastoma is a rare benign odontogenic tumor with a metastasis rate estimated at 2% of cases, mainly involving the lung (80%) and lymph nodes (20%). Methods We hereby present the case of a 26 year old patient with a history of locally recurrent mandibular ameloblastoma who developed a temporal intracranial ameloblastoma tumor requiring a collaborative neurosurgical and maxillo-facial radical surgical approach. Conclusion Although ameloblastomas are histologically benign, the temporal topography questions the dissemination pathophysiology of the tumor (metastasis or local extension through temporal muscle fibers), mainly relevant in cases of multiple recurrences...
May 7, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
Maria Hovorakova, Herve Lesot, Miroslav Peterka, Renata Peterkova
In this review, classical data on the early steps in human odontogenesis are summarized and updated with specific insights into the development of the upper and lower embryonic jaws to help in understanding some oral pathologies. The initial step of human odontogenesis is classically characterized by two parallel horseshoe-shaped epithelial laminae. These originate from the oral epithelium and an ingrowth into the jaw mesenchyme: the internal dental lamina gives rise to deciduous tooth primordia, while the external vestibular lamina represents the developmental base of the oral vestibule...
May 10, 2018: Journal of Anatomy
C Ferretti, J Reyneke, M Heliotis, U Ripamonti
The reconstruction of mandibular defects using particulate grafts is a proven technique that restores the osseous anatomy effectively. Secondary osseous reconstruction can be accomplished with endoscopic assistance and reduced-access incisions if an intermediate spacer is placed during resection. Two patients required reconstruction after resection of mandibular ameloblastomas. We used a modified protocol that involved the implantation of a graft of particulate corticocancellous bone after removal of the spacer, and prepared the recipient site under endoscopic guidance with small extraoral incisions...
June 2018: British Journal of Oral & Maxillofacial Surgery
Artur Fahradyan, Lauren Odono, Jeffrey A Hammoudeh, Lori Kathryn Howell
Ameloblastic carcinomas are rare malignant lesions with 3 mandibular pediatric cases reported in the literature. We present a case of ameloblastic carcinoma in situ in a 15-year-old male with a right mandibular cystic lesion on computed tomography. The incisional biopsy revealed plexiform ameloblastoma. Due to the infiltrating and aggressive nature of the tumor, the patient underwent hemimandibulectomy and immediate reconstruction with a vascularized osteocutaneous fibula free flap. The final pathology was read as ameloblastic carcinoma in situ...
January 1, 2018: Cleft Palate-craniofacial Journal
Chithra Aramanadka, Abhay Taranath Kamath, Adarsh Kudva
Ameloblastoma is locally aggressive benign odontogenic tumour with increased risk of recurrence rate. The choice of treatment depends on the histologic subtype. Radical therapy is the recommended modality for solid ameloblastomas. The possibilities of recurrence even after enbloc resection are still high. The author presents two case reports of recurrent ameloblastomas postradical resection. First case describes the recurrence of ameloblastoma in the bone graft which was used for reconstruction, and the second case depicts recurrence in the infratemporal fossa...
2018: Case Reports in Dentistry
J Sanz-Alonso, N Martínez-Rodríguez, M Martín-Ares, C Barona-Dorado, J Cortés Bretón-Brinkmann, J M Martínez-González
Objective: The objective is to present a clinical case of a 38-year-old male with a maxillary unicystic ameloblastoma treated by means of tumor block resection followed by chin-harvested graft placement in order to place two dental implants for esthetic and functional rehabilitation. Methods: Ameloblastoma is a benign odontogenic tumor characterized by local aggression and a high rate of recurrence; the latter partly depends on how it is treated. Complete resection of the tumor, which usually prevents recurrence, produces bone defects of varying size that must be reconstructed later on...
October 2017: Oral & Implantology
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