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Ameloblastoma

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https://www.readbyqxmd.com/read/28978273/clinical-characterization-of-canine-acanthomatous-ameloblastoma-caa-in-263-dogs-and-the-influence-of-postsurgical-histopathological-margin-on-local-recurrence
#1
Stephanie L Goldschmidt, Cindy M Bell, Scott Hetzel, Jason Soukup
Canine acanthomatous ameloblastoma (CAA) has been reported to be the most common odontogenic tumor in dogs. This retrospective study evaluated 263 dogs with histopathologically confirmed CAA. Within this data set, CAA presents most commonly in the rostral mandible in adult large breed dogs, with golden retriever dogs being overrepresented. Patients with appropriate follow-up after curative intent surgery were evaluated to assess the effect of histopathological margin on local tumor recurrence. No local recurrence was noted in any patient...
January 1, 2017: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/28968331/reconstruction-of-mandibular-segmental-detects-using-transport-disk-distraction-osteogenesis
#2
Tao Li, Yi Man, Ruiye Bi, Nan Jiang, Yunfeng Li, Songsong Zhu
BACKGROUND: Distraction osteogenesis (DO) has become an important alternative for bone defect reconstruction. The study aims to investigate the clinical feasibility and efficiency of transport disc DO (TDDO) for reconstruction of segmental defect of mandible and further dental implant treatment. METHODS: A serial of 6 patients diagnosed with ameloblastoma or keratocystic odontogenic tumor were included in this study. Computed tomography (CT) scanning and panoramic radiograph were performed for preoperative evaluation and surgery planning...
September 29, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28944145/rare-case-of-ameloblastoma-with-pulmonary-metastases
#3
Ivan Valkadinov, Nikolay Conev, Dian Dzhenkov, Ivan Donev
Ameloblastoma is a rare low-grade odontogenic tumor of epithelial origin. The World Health Organization (WHO) has defined malignant ameloblastoma (MA) as a histologically benign-appearing ameloblastoma that has metastasized. Treatment of the primary ameloblastoma usually consists of radical excision of the tumor and adjuvant radiotherapy. Chemotherapy should be used to treat metastases due to its indolent clinical course. Presented here is the case of a 43-year-old woman who was admitted to a hospital in 2006 with a large mass involving the neck and left mandible...
August 2017: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/28942297/ameloblastoma-of-the-jaw-in-three-species-of-rodent-a-domestic-brown-rat-rattus-norvegicus-syrian-hamster-mesocricetus-auratus-and-amargosa-vole-microtus-californicus-scirpensis
#4
B Murphy, A Michel, E B LaDouceur, C Bell, M Lin, D M Imai
Ameloblastoma is a locally aggressive tumour derived from the odontogenic epithelium of the developing tooth germ. This uncommon odontogenic tumour is generally considered benign, but rarely, both distant metastasis and cytological atypia occur and this malignant version is referred to as malignant ameloblastic carcinoma. Here we document a spontaneous malignant ameloblastic carcinoma in a rat (Rattus norvegicus) with metastasis to the submandibular lymph node. We also describe ameloblastomas in two other muroid rodents, an Amaragosa vole (Microtus californicus scirpensis) and a Syrian hamster (Mesocricetus auratus)...
August 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28937331/ameloblastoma-resection-with-immediate-rib-reconstruction-addressing-the-problem-of-mandibular-angle-and-central-bone-bulk
#5
O Kenneth Johnson, Kapil Sharma
Several methods are available to treat mandibular tumours. This case series demonstrates the feasibility of resection and immediate reconstruction with free rib graft in limited resource settings. Innovative technical modifications are described to handle the problem of reconstruction of the angle of the mandible and to provide increased bone bulk in the centre of the mandible. Early postoperative complications are few. Follow-up demonstrates good functional results.
October 2017: Tropical Doctor
https://www.readbyqxmd.com/read/28932051/adenoid-ameloblastoma-with-dentinoid-a-rare-hybrid-variant
#6
Harishchandra K Rai, Shaila M Pai, Anitha Dayakar, H Supriya
Odontogenic tumors comprise an unusual group of lesions of the jaw and present diverse histological patterns. Derived from the primordial tooth-forming tissues, they represent a heterogeneous group of lesions that range from hamartomas to benign and malignant neoplasms of variable aggressiveness. Sporadic case reports and diverse complex histogenetic source also defy categorization of odontogenic tumors. Many can be diagnosed accurately based on the distinctive clinical, radiological and histopathological presentation...
May 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28932038/unicystic-ameloblastoma-in-conjunction-with-peripheral-ameloblastoma-a-unique-case-report-presenting-with-diverse-histological-patterns
#7
Sravani Ghattamaneni, Shilpa Nallamala, Venkateswara Rao Guttikonda
Ameloblastomas are benign epithelial odontogenic neoplasms which are locally aggressive with an insidious growth pattern. Based on the clinical, radiographic, histopathology and behavioral and prognostic aspects, four variants of ameloblastoma are distinguished. They include solid/multicystic ameloblastoma, unicystic ameloblastoma (UA), peripheral ameloblastoma (PA) and desmoplastic ameloblastoma. UA and PA are two variants that have no clinical or radiological resemblance to each other. A case of simultaneous occurrence of these two lesions displaying an array of different histopathological entities together, with a note on pathological insight, has been reported in a 59-year-old adult male patient...
May 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28918236/gene-expression-profiles-of-cell-adhesion-molecules-matrix-metalloproteinases-and-their-tissue-inhibitors-in-canine-oral-tumors
#8
Sirinun Pisamai, Anudep Rungsipipat, Chanin Kalpravidh, Gunnaporn Suriyaphol
Perturbation of cell adhesion can be essential for tumor cell invasion and metastasis, but the current knowledge on the gene expression of molecules that mediate cell adhesion in canine oral tumors is limited. The present study aimed to investigate changes in the gene expression of cell adhesion molecules (E-cadherin or CDH1, syndecan 1 or SDC1, NECTIN2 and NECTIN4), matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs), in canine oral tumors, including benign tumors, oral melanoma (OM) and non-tonsillar oral squamous cell carcinoma (OSCC), by quantitative real-time reverse transcription PCR...
September 8, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28893467/controversies-in-oral-and-maxillofacial-pathology
#9
REVIEW
Zachary S Peacock
Several benign pathologic entities that are commonly encountered by the oral and maxillofacial surgeon remain controversial. From etiology to treatment, no consensus exists in the literature regarding the best treatment of benign lesions, such as the keratocystic odontogenic tumor, giant cell lesion, or ameloblastoma. Given the need for often-morbid treatment to prevent recurrence of these lesions, multiple less-invasive treatments exist in the literature for each entity with little agreement. As the molecular and genomic pathogenesis of these lesions are better understood, directed treatments will hopefully lessen the contention in management...
November 2017: Oral and Maxillofacial Surgery Clinics of North America
https://www.readbyqxmd.com/read/28892943/reconstruction-of-maxilla-with-titanium-mesh-and-fascia-lata-a-case-report
#10
Devkumar Rengaraja, Mohan Jagade, Karthik Rao, Radhika Sonate, Arpita Singhal
Maxillary defect reconstruction has been a grave challenge which unfortunately has stopped many ENT surgeons from attempting maxillectomy due to the fear of reconstruction. With our technique of reconstructing the maxillary defect with titanium mesh and fascia lata, the need for microvascular assistance is obviated. Here we describe a revision case of ameloblastoma of maxilla in a 33-year-old female for which total maxillectomy with reconstruction was done without the aid of microvascular tissue transfer. The aim of this article is to encourage and alleviate the fear among the ENT surgeons, in attempting maxillectomy and its reconstruction for delivering an equally good aesthetic and functional outcome especially at the centres where the facility of plastic assistance is not readily available...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28862228/a-study-of-the-distribution-of-b-cell-lymphoma-leukemia-2-in-odontogenic-cyst-and-tumors-histochemical-study
#11
Khushboo Phull, Rashmi Metgud, Shrikant Patel
INTRODUCTION: The odontogenic keratocyst is known for its aggressiveness, high recurrence rate, and transformation of keratinized epithelia to nonkeratinized squamous epithelium for which inflammation has been suggested to be responsible. B-cell lymphoma/leukemia-2 (Bcl-2) an anti-apoptotic protein, prolongs the life span of epithelial cells and allows proliferation, differentiation, and morphogenesis. MATERIALS AND METHODS: Study was carried out comprising of 90 cases; (30 ameloblastoma, 30 keratocystic odontogenic tumor (KCOT), and 30 radicular cyst)...
July 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28841384/rehabilitation-with-an-implant-supported-metal-acrylic-fixed-prosthesis-after-ameloblastoma-resection-in-mandible-clinical-case-letter
#12
Julide Ozen, Behcet Erol, Sibel Dikicier, Gulce Alp
The majority of patients often have functional problems after undergoing jaw reconstruction. These patients require intense rehabilitation, including surgical and prosthodontic procedures to maximize function, esthetics, and to preserve mastication, speech, and appearance. This clinical report describes the rehabilitation of a patient who had a large tumor resection of ameloblastoma of the mandible resulting in hard and soft tissue deficiency. The mandible was reconstructed with an iliac bone graft with simultaneous tumor removal...
August 25, 2017: Journal of Oral Implantology
https://www.readbyqxmd.com/read/28797453/oncogenic-signalling-pathways-in-benign-odontogenic-cysts-and-tumours
#13
REVIEW
Marina Gonçalves Diniz, Carolina Cavalieri Gomes, Sílvia Ferreira de Sousa, Guilherme Machado Xavier, Ricardo Santiago Gomez
The first step towards the prevention of cancer is to develop an in-depth understanding of tumourigenesis and the molecular basis of malignant transformation. What drives tumour initiation? Why do most benign tumours fail to metastasize? Oncogenic mutations, previously considered to be the hallmark drivers of cancers, are reported in benign cysts and tumours, including those that have an odontogenic origin. Despite the presence of such alterations, the vast majority of odontogenic lesions are benign and never progress to the stage of malignant transformation...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28795546/-unicystic-ameloblastoma-presenting-in-delleman-s-syndrome
#14
Y Gilon, F Thonnart
Ameloblastoma is an odontogenic tumour that represents 1 % of oral tumours but 10 % of odontogenic tumours. Ameloblastoma is characterized by low and noiseless growth, that explains a lot of advanced forms. The tumour is known as benign with local malignity due to its locally invasive behaviour and its recurrence. The treatment choice remains complicated because of recurring nature and large resection in vital anatomical areas. The therapeutic approach will be based on size, anatomical localisation, histologic variants and anatomical complications...
July 2017: Revue Médicale de Liège
https://www.readbyqxmd.com/read/28764951/reconstruction-of-the-bony-chin-using-sagittal-split-osteotomies-of-the-remaining-mandible-a-new-technique-for-a-special-indication-case-report
#15
Berthold H Hell
There are several indications for resecting the bony chin, such as squamous cell carcinoma, sarcoma, or benign tumors of the jaw such as ameloblastoma. Several techniques for reconstruction of the bony chin, such as the use of metal plates and also revascularized free bone grafts of the iliac crest, fibula, or scapula, are common. In the case of poor vascular supply, however, alternative techniques may be necessary. In this report, a new technique is described using pedicled bone flaps from both sagittally split mandibular stumps following chin resection...
September 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28764292/focal-adhesion-kinase-expression-in-ameloblastoma-a-preliminary-observational-study
#16
Snehal Patil, Gargi Sachin Sarode, Sachin C Sarode, Rahul Anand, Shankargouda Patil
INTRODUCTION: Focal Adhesion Kinase (FAK) is a membrane-associated molecule, which plays a major role in tumourigenesis by promoting cell survival, proliferation, migration, and invasion. Hence, FAK is a well known molecule that has been targeted therapeutically for the treatment of various malignancies. Ameloblastoma (AB) is a locally invasive, destructive and recurrent benign odontogenic lesion. Based on these properties, we have hypothesized that odontogenic epithelium of AB could show increased expression of FAK...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28761644/an-extensive-swelling-in-the-anterior-mandible-a-case-report
#17
Nikhil M Kurien, L K Surej Kumar, P B Uma, V Vivek, Anna P Joseph
INTRODUCTION: Glandular odontogenic cyst is a rare developmental odontogenic cyst, which often pose a challenge to diagnose it clinically. PRESENTATION OF A CASE: A 32 year old female patient was referred to the oral and maxillofacial surgery department with a chief complaint of a painless swelling in the anterior mandible, extending from mandibular left premolar to right first molar region, with fluctuancy and egg shell crackling at right premolar region. The associated teeth were firm...
September 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28749026/maxillary-unicystic-ameloblastoma-in-a-6-week-old-filly-evaluated-with-computed-tomography
#18
H L Smith, A J Rosenblatt, W W Suen, H Owen, B J Ahern
CASE REPORT: A 6-week-old Thoroughbred filly was presented for evaluation of an expansile mass overlying the right nasal passage and causing respiratory stertor. On skull radiographs, there was a loculated, soft tissue-opaque mass identified dorsal to the right upper premolars and effacing the right nasal cavity. Computed tomography (CT) revealed a locally extensive mass with relatively benign characteristics located centrally on the tooth root apices of the deciduous second premolar (506)...
August 2017: Australian Veterinary Journal
https://www.readbyqxmd.com/read/28749023/in-this-issue-august-2017-urgent-action-needed-to-facilitate-insecticides-for-screwworm-infestation-%C3%A2-%C3%A2-%C3%A2-experimental-footrot-studies-in-sheep-%C3%A2-%C3%A2-%C3%A2-oestrus-synchronisation-programs-in-dairy-cattle-%C3%A2-%C3%A2-%C3%A2-neuroendodermal-cyst-in-a-dog-%C3%A2-%C3%A2-%C3%A2-stability-of-morphine
#19
EDITORIAL
https://www.readbyqxmd.com/read/28748232/conservative-vs-radical-approach-for-the-treatment-of-solid-multicystic-ameloblastoma-a-systematic-review-and-meta-analysis-of-the-last-decade
#20
Giuseppe Troiano, Mario Dioguardi, Armando Cocco, Luigi Laino, Gabriele Cervino, Marco Cicciu, Domenico Ciavarella, Lorenzo Lo Muzio
PURPOSE: To examine whether a difference exists in the relapse rate between the conservative and radical approaches after the treatment of solid/multicystic ameloblastoma (SMA), a systematic review of the literature based on evidence of the last decade was performed. MATERIALS AND METHODS: The search strategy incorporated examinations of electronic databases, supplemented by hand searches. A search of four electronic databases, including Ovid MEDLINE, PubMed, EMBASE and Web of Science, was carried out for relevant studies published in the English language from January 2005 to September 2015...
July 25, 2017: Oral Health & Preventive Dentistry
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