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Ameloblastoma

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https://www.readbyqxmd.com/read/29453876/prognostic-importance-of-fgf2-and-fgfr1-expression-for-patients-affected-by-ameloblastoma
#1
Felipe Paiva Fonseca, Bernar Monteiro Benites, Ciro Dantas Soares, Thayná Melo de Lima Morais, Gleyson Kleber do Amaral-Silva, Oslei Paes de Almeida, Fernando Augusto Soares, Eduardo Rodrigues Fregnani
BACKGROUND: Fibroblast growth factor 2 (FGF2) and FGF receptor 1 (FGFR1) have been investigated in different human neoplasms and were shown to play important roles in the pathogenesis of these diseases; however, very few is known regarding their prognostic importance in the context of ameloblastoma. Therefore, the aim of this study is to investigate if the expression of FGF2 and FGFR1 is associated with ameloblastoma clinical behavior. METHODS: Fifty-eight cases of ameloblastoma arranged in tissue microarray were submitted to immunohistochemistry against FGF2 and FGFR1...
February 17, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29449727/adenoid-ameloblastoma-with-dentinoid-and-cellular-atypia-a-case-report-and-literature-review
#2
B Ae O Khalele
Adenomatoid odontogenic tumor (AOT) is always benign. Given the very rare recurrence rate and the zero potential of malignant transformation, authors have considered it a hamartoma. Accordingly, 'AOT' is no more than a misnomer. This report, however, describes the first recognition of cellular atypia and plemorphism in a peripheral orophayrngeal AOT which embraces an ameloblastic component. The overall picture was diagnosed, after careful histological and immunohitochemical assessment, as a peripheral adenoid ameloblastoma...
December 2017: Pathologica
https://www.readbyqxmd.com/read/29442096/oral-and-masticatory-rehabilitation-using-osseointegrated-dental-implants-after-resective-treatment-of-multicystic-ameloblastoma-in-the-lower-jaw-with-a-fibula-graft
#3
João Ricardo Almeida Grossi, Tatiana Miranda Deliberador, Tielly Saad, Rafaela Scariot, Joao Cesar Zielak, Allan Fernando Giovanini
Ameloblastoma is an aggressive odontogenic tumor which typically occurs between third and fourth decade of life that often needs resective approach. Immediate reconstruction may show better results. The treatment of multicystic ameloblastoma in the mandible being a rare case that occurred in the late second decade of life, which was surgically removed along with the affected teeth with safety margins, and the region was immediately reconstructed using a vascularized graft, removed from the fibula. Its integration, in combination with osseointegrated dental implants and fixed implant-supported prostheses, restored chewing function and esthetics...
January 2018: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/29431348/new-technique-for-large-mandibular-and-surrounding-soft-tissue-reconstruction-that-uses-an-intraoral-three-dimensional-distractor-for-one-step-transport-disc-distraction-osteogenesis
#4
Antonio Cortese, Mario Caggiano, Giuseppe Pantaleo, Massimo Amato, Pier P Claudio
BACKGROUND: Mandibular reconstruction after ablative surgery is challenging not only for the amount of bone tissue needed following bone loss after benign or malignant tumor surgical removal, but mainly to reconstruct bone shape and structure necessary for subsequent implant insertion to preserve the function (speech, swallowing and chewing) and aesthetic of the lower face. Several different techniques for maxillary bone defects reconstruction have been described. The aim of our work is to describe a new technique for mandibular reconstruction that uses an intramural distractor, which is placed in one surgical step and without the need for a skin incision...
February 9, 2018: Minerva Stomatologica
https://www.readbyqxmd.com/read/29419674/expression-of-tp53-and-il-1%C3%AE-in-unicystic-ameloblastoma-predicts-the-efficacy-of-marsupialization-treatment
#5
Xinyu Zhang, Liu Liu, Xi Yang, Lizhen Wang, Chenping Zhang, Yongjie Hu
In this study, we evaluated the effects of marsupialization in treating unicystic ameloblastoma (UA) and investigated the relationship between TP53 and interleukin 1 α (IL-1α) expression and the clinical outcome of UA treated with marsupialization.Consecutive patients treated with marsupialization and curettage at Shanghai Ninth People's Hospital were included. According to the unified standard, 48 patients were included in this study. Of these, 20 showed a good response, 10 a partial response, and 18 no response, based on the outcome of the marsupialization procedure...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29419594/rate-of-relapse-after-enucleation-of-solid-multicystic-ameloblastoma-followed-by-piezoelectric-or-conventional-peripheral-ostectomy
#6
Giuseppe Troiano, Alessandra Inghingolo, Rosario Serpico, Domenico Ciavarella, Lorenzo Lo Muzio, Gabriele Cervino, Marco Cicciù, Luigi Laino
The use of piezo surgery is characterized by a good cutting ability associated with a higher soft tissues respect. Such skills have led to an increment of the use of such systematic in the clinical practice. The aim of this study was to figure out whether the use of piezo surgery may show clinical advantages when enucleation is followed by peripheral ostectomy for the treatment of solid/multicystic ameloblastoma. A retrospective case-control study was performed, including patients treated with piezo surgery or conventional drilling in a single center in Italy...
February 6, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29415809/expression-profile-of-polycomb-group-proteins-in-odontogenic-keratocyst-and-ameloblastoma
#7
Puangwan Lapthanasupkul, Rachai Juengsomjit, Sopee Poomsawat, Tawepong Arayapisit
Polycomb group (PcG) proteins are repressive chromatin modifiers required for proliferation and development. PcG proteins form two large repressive complexes, namely, Polycomb Repressive Complex 1 and 2. These proteins have been shown to drive tumorigenesis by repressing cell-type specific sets of target genes. Using immunohistochemistry, we investigated the expression patterns of five human PcG proteins, including Bmi-1, Ring1b, Mel-18, Ezh2, and Suz12, in various cellular components of odontogenic keratocysts (OKCs), ameloblastomas and, pericoronal follicles (PFs)...
February 4, 2018: Acta Histochemica
https://www.readbyqxmd.com/read/29391730/odontogenic-tumors-review-of-127-cases-in-marathwada-region-of-maharashtra
#8
Atul Bhagwat, S R Barpande, J D Bhavthankar, M S Mandale, Jayanti Humbe, Preeti Singh
Introduction: Odontogenic tumors (OTs) are a group of heterogeneous lesions derived from epithelial or ectomesenchymal tissues or both, which are part of the tooth-forming apparatus. They range from hamartomatous or nonneoplastic tissue proliferations to malignant neoplasms with metastatic capacity. OTs are comparatively rare, comprising about 4.79% of all oral and maxillofacial biopsy specimens diagnosed. Several retrospective studies carried out in Africa, Asia, Europe and America, show that differences exist in the relative frequency of the various histologic types...
September 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29388014/the-landscape-of-genetic-alterations-in-ameloblastomas-relates-to-clinical-features
#9
Sibel Elif Gültekin, Reem Aziz, Carina Heydt, Burcu Sengüven, Joachim Zöller, Ali Farid Safi, Matthias Kreppel, Reinhard Buettner
Ameloblastoma is a mostly benign, but locally invasive odontogenic tumor eliciting frequent relapses and significant morbidity. Recently, mutually exclusive mutations in BRAF and SMO were identified causing constitutive activation of MAPK and hedgehog signaling pathways. To explore further such clinically relevant genotype-phenotype correlations, we here comprehensively analyzed a large series of ameloblastomas (98 paraffin block of 76 patients) with respect to genomic alterations, clinical presentation, and histological features collected from the archives of three different pathology centers in France, Germany, and Turkey...
February 1, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29383694/evaluation-of-midkine-expression-in-dentigerous-cysts-odontogenic-keratocysts-and-different-types-of-ameloblastoma
#10
Naghmeh Jeiroodi, Mahshid Bagherpour, Razieh Zare, Shima Torabi-Ardakani, Azadeh Andisheh-Tadbir
OBJECTIVE: Midkine is a heparin-binding growth factor whose expression is increased in most tumors, namely ameloblastomas. This study aimed to compare Midkine expression in different odontogenic lesions. MATERIAL AND METHOD: This analytical cross-sectional study was performed on 52 definitely diagnosed odontogenic lesions including 15 dentigerous cysts, 13 odontogenic keratocysts, and 17 unicystic and 5 multicystic ameloblastomas archived from 1997 to 2015. Midkine expression was examined in tissue samples through immunohistochemistry...
January 31, 2018: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/29381612/treatment-of-mandibular-ameloblastoma-involving-the-mandibular-condyle-resection-and-concomitant-reconstruction-with-a-custom-hybrid-total-joint-prosthesis-and-iliac-bone-graft
#11
Mathilde Sarlabous, David J Psutka
AIM: To describe the treatment of ameloblastoma involving the mandibular body and condyle in 3 patients. METHODS: This report describes 3 patients with large ameloblastomas (2 were second recurrences) treated by partial mandibular resection. Involvement of the mandibular condyle in these 3 patients made the reconstruction more challenging. Reconstruction included immediate temporomandibular joint replacement by a custom-made alloplastic total joint and mandibular body (Zimmer-Biomet, Jacksonville, FL)...
January 29, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29354003/diffusion-weighted-mr-imaging-of-unicystic-odontogenic-tumors-for-differentiation-of-unicystic-ameloblastomas-from-keratocystic-odontogenic-tumors
#12
Yifeng Han, Xindong Fan, Lixin Su, Zhenfeng Wang
Objective: Differentiating unicystic ameloblastomas from keratocystic odontogenic tumors (KCOT) is necessary for the planning of different treatment strategies; however, it is difficult based on conventional CT and MR sequences alone. The purpose of this study was to investigate the utility of diffusion-weighted imaging (DWI) and apparent diffusion coefficients (ADCs) in the differentiation of the two tumors. Materials and Methods: We prospectively studied 40 patients with odontogenic cysts and tumors of the maxillomandibular region using conventional MR imaging and DWI...
January 2018: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/29344160/the-role-of-computed-tomography-and-magnetic-resonance-imaging-in-diagnosing-clear-cell-ameloblastoma-a-case-report
#13
Shoko Gamoh, Masahiro Wato, Hironori Akiyama, Kaname Tsuji, Hiroki Ishikawa, Kaori Naruse, Hiroaki Yoshida, Shosuke Morita, Akio Tanaka, Kimishige Shimizutani
Ameloblastoma is the most common and clinically relevant type of odontogenic tumor. Clear cell odontogenic carcinoma is histologically characterized by solid sheets and nests of clear cells, whereas clear cell ameloblastoma (CCAM) is histologically characterized by an ameloblastomatous component intermixed with an extensive clear cell component. A total of 12 reports have been published on the histological etiology for CCAM; however, no reports have made regarding the detailed computed tomography and/or magnetic resonance imaging features of tumors of this type...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29333372/ghost-cell-odontogenic-carcinoma-on-right-mandible-and-its-respective-surgical-reconstruction-a-case-report
#14
Sang Yoon Park, Joonhyoung Park, Do Hyun Kwon, Jae Ho Jeon, Soung Min Kim, Hoon Myoung, Jong Ho Lee
Calcifying cystic odontogenic tumor (CCOT) is defined as an odontogenic cyst-like benign neoplasm that characteristically contains several ghost cells, ameloblastoma-like epithelium, and occasional calcification. Ghost cell odontogenic carcinoma (GCOC), a malignant form of CCOT, is an exceptionally rare malignant tumor. In this report, we present a case of a 53-year-old man whose chief complaint was a solitary mass on the right mandible area. The mass was completely removed through an extraoral surgical approach and reconstructive surgery was performed in two phases...
December 2017: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/29326526/localized-gingival-overgrowths-a-report-of-six-cases
#15
Sohini Banerjee, T K Pal
Localized gingival overgrowths are commonly encountered in our day-to-day clinical practice and often present a diagnostic dilemma to the clinicians. These lesions vary depending on the location, site, extent, histology, and/or etiopathology. Although most of the localized gingival enlargements represent the reactive lesion to plaque accumulation, the differential diagnosis ranges from peripheral fibroma to pyogenic granuloma to peripheral fibroma with ossification and/or calcification, peripheral giant cell granuloma, etc...
October 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29302587/conservative-management-marsupialization-of-unicystic-ameloblastoma-literature-review-and-a-case-report
#16
Jwayoung Kim, Eunkyung Nam, Sukho Yoon
Background: In this study, we present a case of unicystic ameloblastoma (UA) treated by marsupialization followed by surgical enucleation as a conservative approach. UA is a rare, benign, less aggressive, and less invasive variant of ameloblastoma that is observed quite often in younger patients. Radical approaches have effects on the physical and psychological development of a growing young patient; therefore, conservative approaches are widely used for UA management in children. Case presentation: This report described a case of an 11-year-old girl with UA of the mandibular molar-ramus area, which also involved impaction of the second and third molars...
December 2017: Maxillofacial Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29285358/ameloblastic-fibro-odontosarcoma-of-the-mandible-with-active-epithelial-proliferation-a-rare-case-report
#17
Haoman Niu, Junyu Liu, Yu Chen, Ning Geng
Ameloblastic fibro-odontosarcoma (AFOS) is an extremely rare subtype of odontogenic sarcoma, with no more than 19 cases reported in the English literature to date. AFOS is a biphasic neoplasm, with deposits of dentin and enamel matrix. We herein present a case of AFOS with active epithelial proliferation in a 31-year-old female patient. The patient was referred to the West China Hospital of Stomatology (Chengdu, China) due to a 6-month history of a swelling in the left mandible. Following clinical and radiological examination, the initial preoperative diagnosis was ameloblastoma, with local invasion and the possibility of malignant transformation...
December 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29274152/the-epidemiology-treatment-and-complication-of-ameloblastoma-in-east-indonesia-6-years-retrospective-study
#18
M Ruslin, F-N Hendra, A Vojdani, D Hardjosantoso, M Gazali, A Tajrin, J Wolff, T Forouzanfar
BACKGROUND: Ameloblastoma is a neoplasm classified as a benign epithelial odontogenic tumor of the jaws, grow slowly and are locally invasive. The aim of the present study was to investigate the incidence, treatment, and complication of patients with ameloblastoma in East-Indonesia during six years retrospective study. MATERIAL AND METHODS: This retrospective study included 84 patients who were diagnosed with ameloblastoma from 2011 to 2016. There were 56 patients with treatment data available...
January 1, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29250680/granular-ameloblastoma-report-of-two-cases-with-atypical-cytological-aspects
#19
Shelly Arora, Aadithya Basavaraj Urs, Priya Kumar, Jeyaseelan Augustine, Ravindra Kumar Saran
Ameloblastoma is an aggressive odontogenic tumor, which arises from odontogenic epithelium. Ameloblastomas can present in several clinical and histomorphological patterns. The granular cell variant accounts for only 3.5% to 5% of ameloblastomas. We have presented two cases of granular cell ameloblastoma (GCA) occurring in a 44-year-old and 50-year-old man, respectively. Case No. 1 on incisional biopsy was diagnosed as unicystic ameloblastoma (UA), which later after excisional biopsy was finally diagnosed as GCA owing to the features observed in excisional biopsied tissue...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29247621/peripheral-ameloblastoma-a-study-of-18-cases-and-usage-of-ber-ep4-immunohistochemistry-to-rule-out-a-diagnosis-of-intraoral-basal-cell-carcinoma
#20
Jasbir D Upadhyaya, Indraneel Bhattacharyya, Sarah G Fitzpatrick, Donald M Cohen, Mohammed N Islam
PURPOSE: Peripheral ameloblastoma (PA) is a rare odontogenic tumor arising in the mucosa of tooth-bearing areas of the jaws that typically shows no radiographic evidence of bone involvement. It bears close histologic resemblance to intraoral basal cell carcinoma (IOBCC), an extremely rare entity. In our experience from previous published data, 3 cases of IOBCC were initially misdiagnosed as PA and were later differentiated from PA on the basis of Ber-EP4 protein expression. This unusual but significant experience set the premise for us to rule out a diagnosis of IOBCC by evaluating Ber-EP4 expression in all previously diagnosed cases of PA from the University of Florida Oral Pathology (UFOP) biopsy service archives...
November 23, 2017: Journal of Oral and Maxillofacial Surgery
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