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Ameloblastoma

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https://www.readbyqxmd.com/read/29239921/inferiorly-pedicled-nasolabial-flap-for-reconstruction-of-anterior-maxilla-defects-class-i-and-ii
#1
Qingli Chen, Keremu Abasi, Zhongcheng Gong, Bin Ling, Hui Liu, Bo Shao
OBJECTIVES: The aim of this study was to present the use of inferiorly pedicled nasolabial flap (IPNF) in the reconstruction of anterior maxilla defects class I and II. METHODS: Seven patients, 4 females and 3 males, aging from 38 to 75 (mean = 55.9) years old, from 2014 to 2017 reconstructed anterior part of maxilla with or without oronasal communication were included in this study. Five patients diagnosed with squamous cell carcinoma, 1 patient presented with epithelial-myoepithelial carcinoma, and 1 patient had ameloblastoma...
December 12, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29226086/fibroblasts-promote-the-collective-invasion-of-ameloblastoma-tumor-cells-in-a-3d-coculture-model
#2
Takao Fuchigami, Hirofumi Koyama, Michiko Kishida, Yoshiaki Nishizawa, Mikio Iijima, Toshiro Kibe, Masahiro Ueda, Tohru Kiyono, Yoshimasa Maniwa, Norifumi Nakamura, Shosei Kishida
Ameloblastoma is a benign tumor of the odontogenic epithelium with several histological subtypes. All subtypes of ameloblastoma contain abundant stroma; the tumor cells invade collectively into the surrounding tissues without losing intratumor cell attachments. However, the molecular mechanisms mediating ameloblastoma invasion remain unclear. Here, we evaluated the functional significance of the interactions between ameloblastoma tumor cells and stromal fibroblasts on collective cellular invasion using a three-dimensional cultivation method, double-layered collagen gel hemisphere (DL-CGH) culture...
December 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/29217940/audit-of-oral-histopathology-service-at-a-nigerian-tertiary-institution-over-a-24-year-period
#3
Akindayo O Akinyamoju, Bukola F Adeyemi, Akinyele O Adisa, Chidinma N Okoli
Background: Biopsies are often essential for definitive diagnosis of oro-facial lesions and are a part of oral diagnostic procedures carried out in histopathology laboratories. At present, there is paucity of literature on the audit of oral histopathology services in Nigeria. The objectives of this study were to determine the prevalence of biopsied oral lesions in a Nigerian tertiary institution. Also to profile the usage of oral pathology service and to identify challenges that may be present in an oral histodiagnostic service...
July 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29215451/mandibular-reconstruction-using-a-customized-three-dimensional-titanium-implant-applied-on-the-lingual-surface-of-the-mandible
#4
You-Young Jo, Seong-Gon Kim, Min-Keun Kim, Sung-Ho Shin, Janghoon Ahn, Hyun Seok
A patient had a right mandibular defect due to resection of an ameloblastoma. Previously, the defect had been reconstructed by an iliac bone graft, and subsequently, a titanium mesh with xenograft was used. However, it was not successfully reconstructed. For the recovery of mandible continuity and rehabilitation of jaw movement, we manufactured a customized 3-dimensional titanium implant by computer-aided design and manufacturing and electron beam melting technology. This implant was designed to have a porous body structure and lingual plate...
December 6, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29215444/mandibular-reconstruction-by-osteogenic-distraction-due-to-two-different-injuries
#5
Guilherme Dos Santos Trento, José Maurício Dos Santos Nunes Reis, Eduardo Hochuli-Vieira, Valfrido Antônio Pereira-Filho
Varied factors, whether intrinsic or extrinsic, may lead to a decrease in the bone volume of the jaws. Trauma and pathology can be listed as examples of such factors. The aim of this study is to present the osteogenic distraction technique as alternative to augmentation of low mandibular bone volume caused by different etiologies. The first case reports a mandibular marginal resection of ameloblastoma and the second one reports a male patient presenting mandibular fracture sequelae. Both cases were treated according to the osteogenic distraction technique...
December 6, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29207829/evaluation-of-tumour-associated-macrophages-and-angiogenesis-in-ameloblastoma
#6
Akinyele O Adisa, Samuel E Udeabor, Anna Orlowska, Robert A Sader, Shahram Ghanaati
Introduction: Ameloblastoma is a locally invasive odontogenic neoplasm that has a high recurrence rate. The invasion of adjacent tissue is supported by angiogenesis stimulated by Tumour-Associated Macrophages (TAMs). TAMs are macrophages modified in the milieu of the tumour microenvironment and have very weak or no ability to present antigens. Thus, there is collaboration between the tumour and the tumour microenvironment to maintain tumour enlargement. TAMs exist as the classically activated M1 macrophages that possess antitumour activity and the otherwise activated M2 macrophages that support tumour invasion and metastasis...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29184770/dentinogenic-ghost-cell-tumor-a-rare-case-report-with-review-of-literature
#7
Yash Agrawal, Giridhar S Naidu, Ramanpal Singh Makkad, Ravleen Nagi, Supreet Jain, Dilip R Gadewar, Raman Kataria
Dentinogenic ghost cell tumors (DGCT) are very rare tumors considered as solid variants of calcifying epithelial odontogenic cysts (CEOC). They are locally invasive neoplasms and their main characteristic features are ameloblastoma like odontogenic epithelial proliferation, an aberrant keratinization in the form of ghost cells and dysplastic dentin. DGCT occur as two forms intraosseous (central) and extra osseous (peripheral), of which more aggressive intraosseous variety requires careful monitoring and aggressive local resection to prevent recurrence...
October 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29161784/calcifying-epithelial-odontogenic-cyst
#8
Balaji Manohar, Dhritiman Baidya, Neema Shetty, Aditi Mathur, Barkha Makhijani
The Calcifying Odontogenic Cyst was first described as a distinct clinicopathologic entity by Gorlin and his colleagues in 1962. Gold (1963) chose a similar, but not identical term for the lesion, namely 'keratinizing and calcifying odontogenic cyst'. The calcifying cystic odontogenic tumor (CCOT) is a new designation of calcifying odontogenic cyst (COC) recommended by the 2005 classification of the World Health Organization (WHO). The calcifying odontogenic cyst is not a common lesion; the dentinogenic ghost cell tumor is even less common and should be considered rare...
November 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29124001/ameloblastoma-a-retrospective-analysis-of-31-cases
#9
REVIEW
Girish B Giraddi, Kirti Arora, Aamir Malick Saifi
Aims and objective: To evaluate the surgical treatment given and do a regular follow up to study the recurrence rate and complications of ameloblastoma in our institution. Materials and methods: A total of 31 cases of various subtypes of ameloblastoma, treated with different modalities, in the Department of OMFS, were recalled for a follow up & radiographs were taken along with the clinical examination for any recurrence or complications such as fracture/exposure of the reconstruction plate, loosening of the screw, infection of the graft, any draining sinus/signs of infection...
September 2017: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/29109847/the-pull-through-technique-a-viable-option-for-preserving-the-inferior-alveolar-nerve-during-surgical-resection
#10
REVIEW
Gustavo Boehmer Leite, Suelen Cristina Sartoretto, Fernando César Amazonas Lima, Mônica Calasans-Maia, Rafael Seabra Louro
The aim of this study was to present a new surgical technique used to remove benign mandibular tumors with minimal damage to the inferior alveolar nerve. The pull-through technique was shown using an ameloblastoma surgical resection as an example. This technique consisted in the reconstruction of the lower jaw associating the resection of the lesion with nerve repair at the same surgical time. The resection was performed using the pull-through technique and the inferior alveolar nerve was preserved. After 6 months, the patient presented a recovery of approximately 80% of sensory function...
December 2017: Craniomaxillofacial Trauma & Reconstruction
https://www.readbyqxmd.com/read/29109321/epidemiological-and-clinicopathological-analysis-of-92-odontogenic-tumors-a-5-year-retrospective-study
#11
Ipsita Sharma, Deepa Venkatesh, Geetanjali Bawa, Syed Vaseemuddin, Amit Joseph, Jimmy K Sangtani
INTRODUCTION: Odontogenic tumors (OTs) are a heterogeneous group of lesions that are derived from odontogenic apparatus comprised of odontogenic epithelium, ectomesenchyme, and/ or mesenchymal elements. The OTs show marked geographical variation. This study was conducted to analyze the epidemiology and clinicopathological presentation of OTs based on age, sex, and site. MATERIALS AND METHODS: This study was conducted in Department of Oral Pathology and Microbiology...
November 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29103753/frequent-oncogenic-braf-v600e-mutation-in-odontogenic-keratocyst
#12
Yong Hoon Cha, Eunae Sandra Cho, Hee Eun Kang, Jaemin Ko, Woong Nam, Hyung Jun Kim, Nam Hee Kim, Hyun Sil Kim, In-Ho Cha, Jong In Yook
OBJECTIVES: Odontogenic keratocyst (OKC), also known as keratocystic odontogenic tumor (KCOT), has clinical significance due to its high incidence as well as high recurrence rate after surgical enucleation. Current clinical management for OCK is entirely dependent on surgical approach. While various genetic alterations, such as PTCH1 mutation and loss of heterozygosity in tumor suppressor genes, have been reported, the molecular background of OKC is not well-understood. Although recent identification of BRAF V600E mutation and subsequent activation of mitogen-activated protein kinase (MAPK) pathway in ameloblastoma and odontogenic tumors provide additional options with targeted therapeutics, the molecular background of OKC is not well understood...
November 2017: Oral Oncology
https://www.readbyqxmd.com/read/29075412/low-cost-method-for-obtaining-medical-rapid-prototyping-using-desktop-3d-printing-a-novel-technique-for-mandibular-reconstruction-planning
#13
Ignacio Velasco, Soheil Vahdani, Hector Ramos
BACKGROUND: Three-dimensional (3D) printing is relatively a new technology with clinical applications, which enable us to create rapid accurate prototype of the selected anatomic region, making it possible to plan complex surgery and pre-bend hardware for individual surgical cases. This study aimed to express our experience with the use of medical rapid prototype (MRP) of the maxillofacial region created by desktop 3D printer and its application in maxillofacial reconstructive surgeries...
September 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29053755/micrornas-expression-profile-in-solid-and-unicystic-ameloblastomas
#14
A Setién-Olarra, X Marichalar-Mendia, N G Bediaga, P Aguirre-Echebarria, J M Aguirre-Urizar, A Mosqueda-Taylor
OBJECTIVES: Odontogenic tumors (OT) represent a specific pathological category that includes some lesions with unpredictable biological behavior. Although most of these lesions are benign, some, such as the ameloblastoma, exhibit local aggressiveness and high recurrence rates. The most common types of ameloblastoma are the solid/multicystic (SA) and the unicystic ameloblastoma (UA); the latter considered a much less aggressive entity as compared to the SA. The microRNA system regulates the expression of many human genes while its deregulation has been associated with neoplastic development...
2017: PloS One
https://www.readbyqxmd.com/read/29038235/rare-tumor-clinic-the-university-of-california-san-diego-moores-cancer-center-experience-with-a-precision-therapy-approach
#15
Shumei Kato, Kellie Kurasaki, Sadakatsu Ikeda, Razelle Kurzrock
BACKGROUND: Patients with rare tumors may lack approved treatments and clinical trial access. Although each rare tumor is uncommon, cumulatively they account for approximately 25% of cancers. We recently initiated a Rare Tumor Clinic that emphasized a precision medicine strategy. MATERIALS AND METHODS: We investigated the first 40 patients presenting at the Rare Tumor Clinic. Next-generation sequencing (NGS) of tissue and plasma-derived, circulating-tumor DNA (ctDNA), and protein markers were assessed...
October 16, 2017: Oncologist
https://www.readbyqxmd.com/read/28978273/clinical-characterization-of-canine-acanthomatous-ameloblastoma-caa-in-263-dogs-and-the-influence-of-postsurgical-histopathological-margin-on-local-recurrence
#16
Stephanie L Goldschmidt, Cindy M Bell, Scott Hetzel, Jason Soukup
Canine acanthomatous ameloblastoma (CAA) has been reported to be the most common odontogenic tumor in dogs. This retrospective study evaluated 263 dogs with histopathologically confirmed CAA. Within this data set, CAA presents most commonly in the rostral mandible in adult large breed dogs, with golden retriever dogs being overrepresented. Patients with appropriate follow-up after curative intent surgery were evaluated to assess the effect of histopathological margin on local tumor recurrence. No local recurrence was noted in any patient...
January 1, 2017: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/28968331/reconstruction-of-mandibular-segmental-detects-using-transport-disk-distraction-osteogenesis
#17
Tao Li, Yi Man, Ruiye Bi, Nan Jiang, Yunfeng Li, Songsong Zhu
BACKGROUND: Distraction osteogenesis (DO) has become an important alternative for bone defect reconstruction. The study aims to investigate the clinical feasibility and efficiency of transport disc DO (TDDO) for reconstruction of segmental defect of mandible and further dental implant treatment. METHODS: A serial of 6 patients diagnosed with ameloblastoma or keratocystic odontogenic tumor were included in this study. Computed tomography (CT) scanning and panoramic radiograph were performed for preoperative evaluation and surgery planning...
November 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28944145/rare-case-of-ameloblastoma-with-pulmonary-metastases
#18
Ivan Valkadinov, Nikolay Conev, Dian Dzhenkov, Ivan Donev
Ameloblastoma is a rare low-grade odontogenic tumor of epithelial origin. The World Health Organization (WHO) has defined malignant ameloblastoma (MA) as a histologically benign-appearing ameloblastoma that has metastasized. Treatment of the primary ameloblastoma usually consists of radical excision of the tumor and adjuvant radiotherapy. Chemotherapy should be used to treat metastases due to its indolent clinical course. Presented here is the case of a 43-year-old woman who was admitted to a hospital in 2006 with a large mass involving the neck and left mandible...
August 2017: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/28942297/ameloblastoma-of-the-jaw-in-three-species-of-rodent-a-domestic-brown-rat-rattus-norvegicus-syrian-hamster-mesocricetus-auratus-and-amargosa-vole-microtus-californicus-scirpensis
#19
B Murphy, A Michel, E B LaDouceur, C Bell, M Lin, D M Imai
Ameloblastoma is a locally aggressive tumour derived from the odontogenic epithelium of the developing tooth germ. This uncommon odontogenic tumour is generally considered benign, but rarely, both distant metastasis and cytological atypia occur and this malignant version is referred to as malignant ameloblastic carcinoma. Here we document a spontaneous malignant ameloblastic carcinoma in a rat (Rattus norvegicus) with metastasis to the submandibular lymph node. We also describe ameloblastomas in two other muroid rodents, an Amaragosa vole (Microtus californicus scirpensis) and a Syrian hamster (Mesocricetus auratus)...
August 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28937331/ameloblastoma-resection-with-immediate-rib-reconstruction-addressing-the-problem-of-mandibular-angle-and-central-bone-bulk
#20
O Kenneth Johnson, Kapil Sharma
Several methods are available to treat mandibular tumours. This case series demonstrates the feasibility of resection and immediate reconstruction with free rib graft in limited resource settings. Innovative technical modifications are described to handle the problem of reconstruction of the angle of the mandible and to provide increased bone bulk in the centre of the mandible. Early postoperative complications are few. Follow-up demonstrates good functional results.
October 2017: Tropical Doctor
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