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Ameloblastoma

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https://www.readbyqxmd.com/read/27902954/multi-recurrent-invasive-ameloblastoma-a-surgical-challenge
#1
Fatemah Faras, Fawaz Abo-Alhassan, Yona Israël, Barbara Hersant, Jean-Paul Meningaud
INTRODUCTION: Ameloblastomas are rare head and neck tumors, and yet the most common odontogenic neoplasms. They account for 1% and 11% of all head and neck and odontogenic tumors respectively. Embryologically, they originate from remnants of odontogenic epithelium. Their aggressive, destructive nature, as well as their anticipated high rate of recurrence, even after en bloc resection, poses a surgical predicament. PRESENTATION: We present a case of a 56 year-old Asian female with a multi-recurrent invasive ameloblastoma...
November 21, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27891485/ameloblastic-carcinoma-a-report-of-three-cases
#2
Sravya Kodati, Sumit Majumdar, Divya Uppala, Madhurya Namana
Malignant odontogenic tumours are rare and represent approximately 1% of all oral malignancies. Ameloblastic carcinoma is a rare odontogenic tumour, which is aggressive in nature with extensive local bone destruction that has retained the features of ameloblastic differentiation and also exhibits cytological features of malignancy. It occurs primarily in the mandible in a wide range of age groups. It may arise de-novo or in pre-existing ameloblastoma or odontogenic cyst. The purpose of this report is to present three cases of ameloblastic carcinoma with varying presentations as central and peripheral entities...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27868311/tnf-%C3%AE-induced-il-6-and-mmp-9-expression-in-immortalized-ameloblastoma-cell-line-established-by-htert
#3
K Ohta, T Naruse, Y Ishida, H Shigeishi, T Nakagawa, A Fukui, H Nishi, K Sasaki, I Ogawa, M Takechi
OBJECTIVE: Ameloblastoma (AM) shows locally invasive behaviour. However, biological investigations regarding regulation of gene expression associated with AM pathological features are difficult to perform, because AM cells can be passaged for a few generations due to senescence. We report a newly established immortalized AM cell line, AMB cells, by transfection with human telomerase reverse transcriptase (hTERT). Furthermore, we examined whether TNF-α modulates bone resorption-related genes, IL-6 and MMP-9 in cooperation with TGF-β or IFN-γ...
October 13, 2016: Oral Diseases
https://www.readbyqxmd.com/read/27859616/immunohistochemical-expression-of-podoplanin-d2-40-lymphangiogenesis-and-neoangiogenesis-in-tooth-germ-ameloblastomas-and-ameloblastic-carcinomas
#4
Celeste Sánchez-Romero, Ronell Bologna-Molina, Adalberto Mosqueda-Taylor, Oslei Paes de Almeida
BACKGROUND: Ameloblastoma is a benign but locally aggressive odontogenic tumor, while ameloblastic carcinoma is its malignant counterpart. Angiogenesis and lymphangiogenesis in malignancies have been correlated with higher aggressiveness and poor prognosis, as well as greater expression of podoplanin by tumoral cells. METHODS: Immunohistochemical expression of podoplanin, CD34, and CD105 (endoglin) was evaluated in 53 ameloblastomas and three ameloblastic carcinomas; additionally, immunohistochemistry for podoplanin was also performed in 10 tooth germs...
November 10, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27843757/comparison-between-manual-and-automated-methods-for-ki-67-immunoexpression-quantification-in-ameloblastomas
#5
Rogelio González-González, Nelly Molina-Frechero, Ramón G Carreón-Burciaga, Sandra López-Verdín, Carlos Robles-Bonilla, Vanesa Pereira-Prado, Ronell Bologna-Molina
Ameloblastoma is a common and unpredictable odontogenic tumor with high relapse rates. Several studies assessing the proliferative capacity of these neoplasms have been published, mainly using the protein Ki-67. Cell counts must be completed to determine the cell proliferation rate. Multiple methods have been developed for this purpose. The most widely used method is the labeling index, which has undergone changes over time to better facilitate cell counting. Here, we compared manual cell counting methods with automated cell counting (ImmunoRatio) to determine the relative effectiveness of these methods...
2016: Analytical Cellular Pathology (Amsterdam)
https://www.readbyqxmd.com/read/27829762/-evaluation-of-safety-margin-in-ameloblastoma-of-the-mandible-by-surgical-radiological-and-histopathological-methods-an-evidence-based-study
#6
S Kalaiselvan, A V Dharmesh Kumar Raja, B Saravanan, A Srivel Vigneswari, Ramesh Srinivasan
OBJECTIVE: The purpose of this study is to elicit the amount of safety margin necessary around the ameloblastic lesion in view of preventing further recurrence. MATERIALS AND METHODS: The study consisted of 25 cases of mandibular ameloblastoma. Diagnosis was based on clinical and radiological analysis and confirmed by histopathological report. An incisional biopsy was done preoperatively to confirm the diagnosis. Segmental resection was planned for all the cases...
October 2016: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/27806852/ameloblastoma-vs-basal-cell-carcinoma-an-immunohistochemical-comparison
#7
Salam N Jawad, Bashar H Abdullah
Despite behavioral mimicry of ameloblastoma (AB) and basal cell carcinoma (BCC), they are classified at 2 extremes within pertinent WHO classifications with respect to benign and malignant designation. This study aims to appraise the current allocation of AB in the classification through an immunohistochemical comparison of some aspects of behavior with BCC. Sections from retrospectively retrieved formalin-fixed, paraffin-embedded tissue blocks of AB (n = 37) and BCC (n = 34) were comparatively examined for the immunohistochemical expression for Ki-67, Bcl-2, MMP-2, MMP-9, CD31, and D2-40 monoclonal antibodies...
December 2016: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/27793625/ameloblastoma-of-the-jaws-management-and-recurrence-rate
#8
A Laborde, R Nicot, T Wojcik, J Ferri, G Raoul
INTRODUCTION: Ameloblastoma is a rare, benign odontogenic tumour associated with a high recurrence rate. It accounts for 1% of all tumours of the jaws. The purpose of this study was to compare the ameloblastoma recurrence rate according to the type of treatment: radical or conservative. PATIENTS AND METHODS: All patients with a diagnosis of ameloblastoma between 1991 and 2013 were retrospectively identified in order to extract topographic, radiological, and histological data and the type of treatment: conservative (marsupialization, enucleation, curettage) or radical (segmental resection) and to compare the recurrence rate according to the type of treatment...
October 25, 2016: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/27780042/immunoexpression-of-bmp-2-and-bmp-4-and-their-receptors-bmpr-ia-and-bmpr-ii-in-ameloblastomas-and-adenomatoid-odontogenic-tumors
#9
Marcelo Anderson Barbosa Nascimento, Cassiano Francisco Weege Nonaka, Carlos Augusto Galvão Barboza, Roseana de Almeida Freitas, Leão Pereira Pinto, Lélia Batista de Souza
OBJECTIVES: The present study evaluated the immunohistochemical expression of BMP-2 and BMP-4 and of their receptors (BMPR-IA and BMPR-II) in solid ameloblastoma (SA), unicystic ameloblastoma (UA) and adenomatoid odontogenic tumor (AOT) in order to obtain a better understanding of their role in the development and biological behavior of these tumors. DESIGN: This study analyzed these proteins in 30 cases of SA, 10 cases of UA, and 30 cases of AOT. Immunoexpression was evaluated in the parenchyma and stroma by attributing the following scores: 0, no stained cells; 1, ≤10%; 2, >10% and ≤25%; 3, >25% and ≤50%; 4, >50% and ≤75%...
January 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/27770472/whatsapp-is-an-effective-tool-for-obtaining-second-opinion-in-oral-pathology-practice
#10
Sachin C Sarode, Gargi S Sarode, Rahul Anand, Shankargouda Patil, Hemant Unadkat
BACKGROUND: The aim of this study was to find out the efficacy of WhatsApp application for obtaining second opinion on histopathological diagnosis in oral pathology practice. METHODS: A total of 247 cases comprising of 34 different oral pathologies were photomicrographed using smartphone cameras through compound microscopes and sent for second opinion diagnosis (SOD) to 20 different oral pathologists using WhatsApp. RESULTS: Of 4795 (97.06%) total second opinion received, correct SOD were received for 4710 (98...
October 22, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27761382/role-of-podoplanin-expression-in-deciding-the-invasive-potential-of-ameloblastoma-a-retrospective-ihc-study
#11
Sindhu M Ganvir, Pratima G Khobragade, Swati A Bamane, Ramnivas Kumavat, Amit Dalmia
BACKGROUND: The aim of this study was to investigate the podoplanin expression in epithelial odontogenic tumors both non-aggressive and aggressive, tumors with and without ectomesenchyme and remnants of the odontogenic epithelium from dental follicles (DF) of unerupted teeth and to examine its role in progression and invasion of tumors. METHOD: Thirty paraffin embedded specimens AM (15 were non-aggressive ameloblastomas and 15 ameloblastoma showing aggressive behavior), 15 paraffin embedded specimens of AOT, 15 paraffin embedded specimens of CEOT, 15 paraffin embedded specimens of CCOT were obtained and were analyzed by immunohistochemistry using anti-human podoplanin...
September 2016: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/27756334/maxillary-unicystic-ameloblastoma-a-case-report
#12
Zana Agani, Vjosa Hamiti-Krasniqi, Jehona Recica, Mergime Prekazi Loxha, Fisnik Kurshumliu, Aida Rexhepi
BACKGROUND: Ameloblastoma is a benign epithelial odontogenic tumor. It is often aggressive and destructive, with the capacity to attain great size, erode bone and invade adjacent structures. Unicystic ameloblastoma is a rare odontogenic lesion, with clinical, radiographic and gross features of jaw cysts. The lesion histologically shows typical ameloblastomatous epithelium lining part of the cyst cavity with or without and/or mural tumor growth. Unicystic ameloblastoma usually presents in posterior mandibular ramus region, while it is rare and atypical in posterior maxillary region...
October 18, 2016: BMC Research Notes
https://www.readbyqxmd.com/read/27752195/a-standardized-formula-for-aesthetic-mandibular-reconstruction-using-an-osteocutaneous-fibular-free-flap
#13
Soung Min Kim, Emmanuel K Amponsah, Hui Young Kim, Ik Jae Kwon, Hoon Myoung, Jong Ho Lee
: Ameloblastoma is the most common benign odontogenic tumor of the jaw, and expansional growth of a huge untreated ameloblastoma can result in disturbances in facial aesthetics and function, such as difficulty with mouth opening, swallowing, chewing, breathing, neurologic deficits, and pathologic fractures. Radical wide resection with safety margins and subsequent reconstruction is generally recommended. A fibular free flap (FFF) is commonly used to reconstruct the mandible in order to adequately restore both aesthetic appearance and function...
September 2016: Ghana Medical Journal
https://www.readbyqxmd.com/read/27747382/clinicopathological-and-cell-proliferation-evaluation-of-ameloblastomas-and-keratocystic-odontogenic-tumors-a-10%C3%A2-year-retrospective-study
#14
Leorik Pereira da Silva, Marianna Sampaio Serpa, Thalita Santana, George João Ferreira do Nascimento, Emanuel Sávio de Souza Andrade, Ana Paula Veras Sobral
Odontogenic tumors (OTs) are important lesions of the gnathic bones due to their clinicopathological heterogeneity and variable biological behavior; therefore, epidemiological studies are needed to outline the incidence and behavior of these tumors. To evaluate the incidence and epidemiological profile of ameloblastoma (AMB) and keratocystic odontogenic tumor (KCOT) from an oral pathology service, and correlate morphological findings of these tumors with the immunoexpression of a cellular proliferation marker (Ki-67), a retrospective study (2002-2012) was conducted to characterize demographic, clinical, radiological, and morphological data of AMBs and KCOTs...
October 17, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27746893/the-regulation-of-bone-turnover-in-ameloblastoma-using-an-organotypic-in-vitro-co-culture-model
#15
Tuula M Eriksson, Richard M Day, Stefano Fedele, Vehid M Salih
Ameloblastoma is a rare, odontogenic neoplasm with benign histopathology, but extensive, local infiltrative capacity through the bone tissue it originates in. While the mechanisms of ameloblastoma invasion through the bone and bone absorption are largely unknown, recent investigations have indicated a role of the osteoprotegerin/receptor activator of nuclear factor kappa-B ligand regulatory mechanisms. Here, we present results obtained using a novel in vitro organotypic tumour model, which we have developed using tissue engineering techniques...
January 2016: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/27737362/expression-of-cd90-and-p75ntr-stem-cell-markers-in-ameloblastomas-a-possible-role-in-their-biological-behavior
#16
Fernanda Paula Yamamoto Silva, Andrielle Dias, Carolinne Almeida Coelho, Eliete Neves Guerra, Ana Elizia Mascarenhas Marques, Daniel de Almeida Decurcio, Andrea Mantesso, Sérgio Elias Vieira Cury, Brunno Santos de Freitas Silva
Multicystic and unicystic ameloblastomas are benign odontogenic tumors that present distinct biological behavior. The investigation of stem cells has become an important branch of tumor biology, with several studies addressing the possible role of these cells in tumor growth, angiogenesis, progression, infiltration and invasiveness. This study evaluated the immunohistochemical expression of CD90(Thy-1) and P75NTR stem cell markers in multicystic and unicystic ameloblastomas. Seventeen (17) samples of ameloblastomas (multicystic, n = 10; unicystic, n = 7) were submitted to immunohistochemical reactions and graded semi-quantitatively...
October 10, 2016: Brazilian Oral Research
https://www.readbyqxmd.com/read/27725996/non-vascularised-iliac-crest-bone-graft-for-immediate-reconstruction-of-lateral-mandibular-defect
#17
Eyituoyo Okoturo
INTRODUCTION: Mandibular defect reconstruction is extremely important to achieving an improved quality of life of patients as this bony defect influences facial harmony and aesthetics. Reconstruction of mandibular defects at our centre comprises use of reconstruction plate, non-vascularised anterior iliac crest graft and vascularised fibula flap. Despite the large mandibular defect recorded in our developing environment, non-vascularised iliac crest graft continues to play a role in its exclusive use for lateral mandibular defects...
October 10, 2016: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27721617/molecular-and-genetic-aspects-in-the-etiopathogenesis-of-ameloblastoma-an-update
#18
Ravleen Nagi, Shashikant Sahu, N Rakesh
Ameloblastoma is the second most common benign epithelial odontogenic tumor and though it is of a benign nature, it is locally invasive, has a high recurrence rate and could potentially become malignant. Many theories have been proposed to explain the pathogenesis of ameloblastoma. Proper understanding of the pathogenic mechanism involved in ameloblastoma and its proliferation aids in constituting proper treatment of choice at an early stage, preventing morbidity associated with extensive therapy. An attempt has been made to discuss the current concepts related to molecular and genetic changes that occur in ameloblastoma as these could affect treatment plan and prognosis...
September 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/27682262/rare-copy-number-alterations-and-copy-neutral-loss-of-heterozygosity-revealed-in-ameloblastomas-by-high-density-whole-genome-microarray-analysis
#19
Marina Gonçalves Diniz, Alessandra Pires Duarte, Rolando A Villacis, Bruna V A Guimarães, Luiz Cláudio Pires Duarte, Sílvia R Rogatto, Ricardo Santiago Gomez, Carolina Cavaliéri Gomes
BACKGROUND: Ameloblastoma (unicystic, UA, or multicystic, MA) is a rare tumor associated with bone destruction and facial deformity. Its malignant counterpart is the ameloblastic carcinoma (AC). The BRAFV600E mutation is highly prevalent in all these tumors subtypes and cannot account for their different clinical behaviors. METHODS: We assessed copy number alterations (CNAs) and copy-neutral loss of heterozygosity (cnLOH) in UA (n = 2), MA (n = 3), and AC (n = 1) using the CytoScan HD Array (Affymetrix) and the BRAFV600E status...
September 28, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27681305/braf-v600e-expression-correlates-with-ameloblastoma-aggressiveness
#20
Eduardo Rodrigues Fregnani, Danyel Elias da Cruz Perez, Oslei Paes de Almeida, Felipe Paiva Fonseca, Fernando Augusto Soares, Gilberto de Castro Junior, Fábio Abreu de Alves
AIMS: The aim of this study was to investigate whether the expression of BRAF-V600E determines an aggressive clinical and molecular presentation of ameloblastoma. METHODS AND RESULTS: Ninety-three cases of solid ameloblastomas were arranged in a 1.0-mm tissue microarray block. Immunohistochemistry against a large panel of cytokeratins (CK), epidermal growth factor receptor (EGFR), parathyroid hormone-related peptide (PTHrP), syndecan-1, Ki67, p53, and BRAF-V600E were done...
September 28, 2016: Histopathology
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