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https://www.readbyqxmd.com/read/27920723/sex-dependent-anti-stress-effect-of-an-%C3%AE-5-subunit-containing-gabaa-receptor-positive-allosteric-modulator
#1
Sean C Piantadosi, Beverly J French, Michael M Poe, Tamara Timić, Bojan D Marković, Mohan Pabba, Marianne L Seney, Hyunjung Oh, Beverley A Orser, Miroslav M Savić, James M Cook, Etienne Sibille
Rationale: Current first-line treatments for stress-related disorders such as major depressive disorder (MDD) act on monoaminergic systems and take weeks to achieve a therapeutic effect with poor response and low remission rates. Recent research has implicated the GABAergic system in the pathophysiology of depression, including deficits in interneurons targeting the dendritic compartment of cortical pyramidal cells. Objectives: The present study evaluates whether SH-053-2'F-R-CH3 (denoted "α5-PAM"), a positive allosteric modulator selective for α5-subunit containing GABAA receptors found predominantly on cortical pyramidal cell dendrites, has anti-stress effects...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27917785/dipyrone-ameliorates-behavioural-changes-induced-by-unpredictable-chronic-mild-stress-gender-differences
#2
Olcay E Kiroğlu, Kübra E Demirkol, Fatih Berktaş, Arash A Yegani, Ayşegül Kirpik, Erkan Maytalman, Mahmut Ünverdi, Fazilet Aksu
PURPOSE: Antidepressant effects of analgesics have been investigate in both clinical and experimental studies. The purpose of this study was to investigate if the analgesic-antipyretic drug, dipyrone, also had antidepressant-like effects. METHODS: Depression-like effects were investigated in an unpredictable chronic mild stress (UCMS) model in both male and female mice. Cage changes, light-dark cycle reversal, cage tilting, wet floor, empty cage, foreign material on the floor and predator sounds were used to induce light stress at different times for six weeks...
December 1, 2016: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/27904425/association-of-thyroid-profile-and-prolactin-level-in-patient-with-secondary-amenorrhea
#3
Sujata Shrestha, Sunita Neupane, Narayan Gautam, Raju Kumar Dubey, Amit Chandra Jha, Nilesh Raj Doshi, Archana Jayan
BACKGROUND: Amenorrhea is the absence of menstrual periods. It has multiple social consequences as it may leads to infertility. This case control study was conducted for determining the association of thyroid hormones with hyperprolactinemia in patient with amenorrhea. METHODS: We investigated 50 women with diagnosed cases of secondary amenorrhoea, who attended UCMS hospital, for hormonal evaluations. Fifty two healthy women were taken as the controls. The thyroid dysfunction and serum prolactin level were reviewed in cases and in the controls...
September 2016: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/27904147/penile-constitutive-nitric-oxide-synthase-expression-in-rats-exposed-to-unpredictable-chronic-mild-stress-role-of-inflammation
#4
T D Şahin, Y Yazır, T Utkan, S S Göçmez, D Bayramgürler
Chronic psychological stress cause erectile dysfunction (ED). Considering recent evidence that tumor necrosis factor-α (TNF-α) levels are increased in serum of patients with ED, the present study investigated the effects of infliximab (a TNF-α blocker) on endothelial nitric oxide synthase (eNOS) and neuronal NOS (nNOS) immunoreactivity of rat penile corpus cavernosum in unpredictable chronic mild stress (UCMS). Male adult rats were randomly divided into three groups (n=8 per group): Control, UCMS and UCMS+infliximab...
December 1, 2016: International Journal of Impotence Research
https://www.readbyqxmd.com/read/27828964/chronic-treatment-with-the-ido1-inhibitor-1-methyl-d-tryptophan-minimizes-the-behavioural-and-biochemical-abnormalities-induced-by-unpredictable-chronic-mild-stress-in-mice-comparison-with-fluoxetine
#5
Anthony Laugeray, Jean-Marie Launay, Jacques Callebert, Oguz Mutlu, Gilles J Guillemin, Catherine Belzung, Pascal R Barone
We demonstrated that confronting mice to the Unpredictable Chronic Mild Stress (UCMS) procedure-a validated model of stress-induced depression-results in behavioural alterations and biochemical changes in the kynurenine pathway (KP), suspected to modify the glutamatergic neurotransmission through the imbalance between downstream metabolites such as 3-hydroxykynurenine, quinolinic and kynurenic acids. We showed that daily treatment with the IDO1 inhibitor 1-methyl-D-tryptophan partially rescues UCMS-induced KP alterations as does the antidepressant fluoxetine...
2016: PloS One
https://www.readbyqxmd.com/read/27818278/effect-of-amitriptyline-treatment-on-neurofilament-h-protein-in-an-experimental-model-of-depression
#6
Maria Domenica Sanna, Carla Ghelardini, Nicoletta Galeotti
It has been proposed that depression is associated with dysfunction of hippocampal plasticity. Novel hypotheses suggest that antidepressants induce neuronal structural plasticity, although the underlying mechanisms still remain unclear. Therefore, the aim of this study was to investigate the effects of amitriptyline on levels of phosphorylated heavy neurofilament subunit (NF-H) in the hippocampus of mice exposed to acute and chronic behavioral despair paradigms. Immunoblotting experiments showed that animals exposed to the tail suspension test (TST) displayed diminished levels of pNF-H 24h after testing...
November 3, 2016: Brain Research Bulletin
https://www.readbyqxmd.com/read/27781466/network-complement-transitions-symmetries-and-cluster-synchronization
#7
Takashi Nishikawa, Adilson E Motter
Synchronization in networks of coupled oscillators is known to be largely determined by the spectral and symmetry properties of the interaction network. Here, we leverage this relation to study a class of networks for which the threshold coupling strength for global synchronization is the lowest among all networks with the same number of nodes and links. These networks, defined as being uniform, complete, and multi-partite (UCM), appear at each of an infinite sequence of network-complement transitions in a larger class of networks characterized by having near-optimal thresholds for global synchronization...
September 2016: Chaos
https://www.readbyqxmd.com/read/27778048/optimality-and-stability-of-intentional-and-unintentional-actions-ii-motor-equivalence-and-structure-of-variance
#8
Behnoosh Parsa, Vladimir M Zatsiorsky, Mark L Latash
We address the nature of unintentional changes in performance in two papers. This second paper tested hypotheses related to stability of task-specific performance variables estimated using the framework of the uncontrolled manifold (UCM) hypothesis. Our first hypothesis was that selective stability of performance variables would be observed even when the magnitudes of those variables drifted unintentionally because of the lack of visual feedback. Our second hypothesis was that stability of a variable would depend on the number of explicit task constraints...
October 24, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/27756096/protective-effect-of-irbesartan-an-angiotensin-at1-receptor-antagonist-in-unpredictable-chronic-mild-stress-induced-depression-in-mice
#9
M Ayyub, A K Najmi, M Akhtar
Objective: Oxidative stress and alternation of renin-angiotensin system has been implicated in the pathophysiology of various cardio vascular, endocrine including mood and anxiety disorders. The present study evaluated the role of irbesartan in stress induced different models of depression. Materials and method: Mice were treated with irbesartan (40 mg/kg), fluoxetine (25 mg/kg) alone in combination orally. Drugs treatment started after 2 weeks from the beginning of the unpredictable mild stress (UCMS) protocol...
October 18, 2016: Drug Research
https://www.readbyqxmd.com/read/27745738/determination-of-hydrocarbons-transported-by-urban-runoff-in-sediments-of-s%C3%A3-o-gon%C3%A3-alo-channel-pelotas-rs-brazil
#10
Pedro J Sanches Filho, Emerson M Böhm, Giani M B Böhm, Gissele O Montenegro, Lucas A Silveira, Glauco R Betemps
A high concentration of hydrocarbons in the environment is indicative of pollution. To evaluate the effect of hydrocarbons transported by urban runoff, the present study analyzed total petroleum hydrocarbons (TPHs), aliphatic hydrocarbons (AHs), unresolved complex mixture (UCM), and n-alkanes of the sediments of the canal that cross the urban area of Pelotas, Rio Grande do Sul, Brazil. The carbon preference index (CPI), terrigenous/aquatic ratio (TAR), and pristane/phytane ratio were determined. The TPH content ranged from 177,043...
October 11, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/27733820/increasing-pain-sensation-eliminates-the-inhibitory-effect-of-depression-on-evoked-pain-in-rats
#11
Ning Wang, Sheng-Guang Li, Xiao-Xiao Lin, Yuan-Lin Su, Wei-Jing Qi, Jin-Yan Wang, Fei Luo
Although previous studies have suggested that depression may be associated with inhibition of evoked pain but facilitation of spontaneous pain, the mechanisms underlying these relationships are unclear. The present study investigated whether the difference between evoked and spontaneous pain on sensory (descending inhibition) and affective (avoidance motivation) components contributes to the divergent effects of depression on them. Depressive-like behavior was produced in male Wistar rats by unpredictable chronic mild stress (UCMS)...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27692833/risk-of-lymph-node-metastases-in-pathological-gleason-score%C3%A2-6-prostate-adenocarcinoma-analysis-of-institutional-and-population-based-databases
#12
Hannah Wenger, Adam B Weiner, Aria Razmaria, Gladell P Paner, Scott E Eggener
INTRODUCTION: Several institutional studies have suggested that pathological Gleason score≤6 prostate cancer has little or no capacity for metastasis. MATERIALS AND METHODS: Using the Surveillance, Epidemiology, and End Results database (SEER, 2004-2011, n = 19,594) and the National Cancer Database (NCDB, 2004-2013, n = 57,540), we identified patients with pathological Gleason score≤6 prostate cancer following radical prostatectomy and lymph node dissection...
September 27, 2016: Urologic Oncology
https://www.readbyqxmd.com/read/27649928/tlr3-preconditioning-enhances-the-therapeutic-efficacy-of-umbilical-cord-mesenchymal-stem-cells-in-tnbs-induced-colitis-via-the-tlr3-jagged-1-notch-1-pathway
#13
Y Qiu, J Guo, R Mao, K Chao, B-L Chen, Y He, Z-R Zeng, S-H Zhang, M-H Chen
Toll-like receptor-3 (TLR3) priming may enhance mesenchymal stem cell (MSC) immunosuppressive activity, but this mechanism has not been investigated in the context of inflammatory bowel disease. Thus, we assessed the immunosuppressive properties of TLR3-primed MSCs using a trinitrobenzene sulfonate (TNBS)-induced mouse model of colitis. Intraperitoneally injected polyribocytidylic acid (poly (I:C)- (a ligand of TLR3) primed human umbilical cord-derived MSCs (hUC-MSCs) migrated to the inflamed colon and effectively improved clinical and pathological manifestations in colitic mice compared with mice treated with unstimulated hUC-MSCs (UCMs)...
September 21, 2016: Mucosal Immunology
https://www.readbyqxmd.com/read/27587231/hydrocarbons-in-sediments-along-a-tropical-estuary-shelf-transition-area-sources-and-spatial-distribution
#14
Daniele Claudino Maciel, José Roberto Botelho de Souza, Satie Taniguchi, Márcia Caruso Bícego, Carlos Augusto França Schettini, Eliete Zanardi-Lamardo
Estuaries generally act as sediment traps and may retain a range of contaminants associated to this matrix. Aliphatic hydrocarbons (AHs) were investigated in Capibaribe Estuarine System and adjacent shelf, Northeast of Brazil, to evaluate the contamination and to better understand its functionality related to the coast. Fourteen sediment samples were analyzed, using gas chromatography with flame ionization detection. Total AHs concentrations ranged from 7.5 to 190.3μgg(-1) and n-alkanes ranged from below detection limit (<DL) to 9...
August 29, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/27571854/-not-available
#15
Rosa M Ortega Anta
En el presente suplemento de la revista Nutrición Hospitalaria se resumen las conferencias presentadas en las Terceras Jornadas UCMASEN (Universidad Complutense de Madrid - Asociación de Estudios Nutricionales), bajo el título "Nutrición como estrategia en la mejora y promoción de la salud", que se celebraron durante los días 3 y 4 de febrero de 2016 en la Facultad de Farmacia de la Universidad Complutense de Madrid. Estas Jornadas han sido una actividad promovida por el grupo de investigación UCM-VALORNUT y han contado con el apoyo institucional de la Fundación Española de la Nutrición (FEN)...
July 12, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27564579/randomised-control-trial-showed-that-delayed-cord-clamping-and-milking-resulted-in-no-significant-differences-in-iron-stores-and-physical-growth-parameters-at-one-year-of-age
#16
Shivam Agarwal, Vijay Jaiswal, Dharamveer Singh, Prateek Jaiswal, Amit Garg, Amit Upadhyay
AIM: Placental redistribution has been shown to improve haematological outcomes in the immediate neonatal period and early infancy. This study compared the effects of delayed cord clamping (DCC) and umbilical cord milking (UCM) on haematological and growth parameters at 12 months of age. METHODS: This was a follow-up study of a randomised control trial, conducted in a tertiary care paediatric centre from August 2013 to August 2014. We studied 200 apparently healthy Indian infants randomised at birth to receive DCC for 60-90 seconds or UCM...
November 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27562628/effects-of-chronic-stress-on-cognition-in-male-samp8-mice
#17
Jinhua Wang, Jie Yuan, Jingjuan Pang, Jiang Ma, Bing Han, Yuan Geng, Li Shen, Hualong Wang, Qinying Ma, Yanyong Wang, Mingwei Wang
BACKGROUND/AIMS: Chronic stress can lead to cognitive impairment. Senescence-accelerated mouse prone 8 (SAMP8) is a naturally occurring animal model that is useful for investigating the neurological mechanisms of Alzheimer's disease. Here we investigated the impact and mechanisms of chronic stress on cognition in male SAMP8 mice. METHODS: Male 6-month- old SAMP8 and SAMR1 (senescence-accelerated mouse resistant 1) mice strains were randomly divided into 4 groups...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27546821/anticipatory-synergy-adjustments-reflect-individual-performance-of-feedforward-force-control
#18
Shunta Togo, Hiroshi Imamizu
We grasp and dexterously manipulate an object through multi-digit synergy. In the framework of the uncontrolled manifold (UCM) hypothesis, multi-digit synergy is defined as the coordinated control mechanism of fingers to stabilize variable important for task success, e.g., total force. Previous studies reported anticipatory synergy adjustments (ASAs) that correspond to a drop of the synergy index before a quick change of the total force. The present study compared ASA's properties with individual performances of feedforward force control to investigate a relationship of those...
October 6, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27544207/antidepressant-like-and-anxiolytic-like-effects-of-zbd-2-a-novel-ligand-for-the-translocator-protein-18%C3%A2-kda
#19
Dong-Sheng Wang, Jing Han, Shuo Li, Ting Sun, Yan-Yan Guo, Wen-Bo Kang, Zhen Tian, Jian-Ning Zhao, Gang Liu, Shui-Bing Liu, Ming-Gao Zhao
Activation of translocator protein (18 kDa) (TSPO) plays an important role to mediate rapid anxiolytic efficacy in stress response and stress-related disorders by the production of neurosteroids. However, little is known about the ligand of TSPO on the anxiety-like and depressive behaviors and the underlying mechanisms in chronic unpredictable mild stress (UCMS) mice. In the present study, a novel ligand of TSPO, ZBD-2 [N-benzyl-N-ethyl-2-(7,8-dihydro-7-benzyl-8-oxo-2-phenyl-9H-purin-9-yl) acetamide] synthesized by our laboratory, was used to evaluate the anxiolytic and antidepressant efficacy and to elucidate the underlying mechanisms...
August 20, 2016: Neuromolecular Medicine
https://www.readbyqxmd.com/read/27462215/uncontrolled-manifold-reference-feedback-control-of-multi-joint-robot-arms
#20
Shunta Togo, Takahiro Kagawa, Yoji Uno
The brain must coordinate with redundant bodies to perform motion tasks. The aim of the present study is to propose a novel control model that predicts the characteristics of human joint coordination at a behavioral level. To evaluate the joint coordination, an uncontrolled manifold (UCM) analysis that focuses on the trial-to-trial variance of joints has been proposed. The UCM is a nonlinear manifold associated with redundant kinematics. In this study, we directly applied the notion of the UCM to our proposed control model called the "UCM reference feedback control...
2016: Frontiers in Computational Neuroscience
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