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https://www.readbyqxmd.com/read/28490697/-effect-of-left-ventricular-hypertrophy-and-deformation-on-cardiac-function-in-patients-with-uremia-cardiomyopathy-by-using-quantitative-speckle-tracking-technology
#1
Yi Zheng, Xiaohong Yang, Qiping Zhou, Yaoyao Huang, Fan Zhang, Liangyu Wang
To evaluate the effect of left ventricular hypertrophy and deformation on cardiac function in patients with uremic cardiomyopathy (UCM) by using the technology of two dimensional speckle tracking imaging (2D-STI).
 Methods: A total of 67 UCM patients were randomly divided into the normal cardiac function group (subgroup A, 32 cases) and the abnormal cardiac function group (subgroup B, 35 cases) according to the New York Heart Association points (NYHA-P). A total of 30 healthy subjetcs served as the control group...
April 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28486779/expansion-strategies-for-human-mesenchymal-stromal-cells-culture-under-xeno-free-conditions
#2
Patrícia Aparecida Tozetti, Samia Rigotto Caruso, Amanda Mizukami, Taisa Risque Fernandes, Fernanda Borges da Silva, Fabiola Traina, Dimas Tadeu Covas, Maristela Delgado Orellana, Kamilla Swiech
Choosing the culture system and culture medium used to produce cells are key steps towards a safe, scalable and cost-effective expansion bioprocess for cell therapy purposes. The use of AB human serum (AB HS) as an alternative xeno-free supplement for mesenchymal stromal cells (MSC) cultivation has increasingly gained relevance due to safety and efficiency aspects. Here we have evaluated different scalable culture systems to produce a meaningful number of umbilical cord matrix-derived MSC (UCM MSC) using AB HS for culture medium supplementation during expansion and cryopreservation to enable a xeno-free bioprocess...
May 9, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/28484496/insulin-promotes-the-proliferation-of-human-umbilical-cord-matrix-derived-mesenchymal-stem-cells-by-activating-the-akt-cyclin-d1-axis
#3
Peng Li, Jinsong Wei, Xiang Gao, Bo Wei, Hao Lin, Rui Huang, Yanru Niu, Kyu Lim, Kaipeng Jing, Jiaqi Chu
Background. The functions of insulin in mesenchymal stem cells (MSC) remain poorly understood. Methods. MSC from human umbilical cord matrix (UCM) cultured in serum-free media (SFM) with or without insulin were subjected to various molecular biological analyses to determine their proliferation and growth states, expression levels of Akt-cyclin D1 signaling molecules, and in vitro differentiation capacities. Results. Insulin accelerated the G1-S cell cycle progression of UCM-MSC and significantly stimulated their proliferation and growth in SFM...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28455740/motor-equivalence-and-structure-of-variance-multi-muscle-postural-synergies-in-parkinson-s-disease
#4
Ali Falaki, Xuemei Huang, Mechelle M Lewis, Mark L Latash
We explored posture-stabilizing multi-muscle synergies with two methods of analysis of multi-element, abundant systems: (1) Analysis of inter-cycle variance; and (2) Analysis of motor equivalence, both quantified within the framework of the uncontrolled manifold (UCM) hypothesis. Data collected in two earlier studies of patients with Parkinson's disease (PD) were re-analyzed. One study compared synergies in the space of muscle modes (muscle groups with parallel scaling of activation) during tasks performed by early-stage PD patients and controls...
April 28, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28444170/neuronal-activity-tgf%C3%AE-signaling-and-unpredictable-chronic-stress-modulate-transcription-of-gadd45-family-members-and-dna-methylation-in-the-hippocampus
#5
Daniela Grassi, Henriette Franz, Riccardo Vezzali, Patrick Bovio, Stefanie Heidrich, Fariba Dehghanian, Natalia Lagunas, Catherine Belzung, Kerstin Krieglstein, Tanja Vogel
Neuronal activity is altered in several neurological and psychiatric diseases. Upon depolarization not only neurotransmitters are released but also cytokines and other activators of signaling cascades. Unraveling their complex implication in transcriptional control in receiving cells will contribute to understand specific central nervous system (CNS) pathologies and will be of therapeutically interest. In this study we depolarized mature hippocampal neurons in vitro using KCl and revealed increased release not only of brain-derived neurotrophic factor (BDNF) but also of transforming growth factor beta (TGFB)...
April 21, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28433620/depressive-behavior-induced-by-unpredictable-chronic-mild-stress-increases-dentin-hypersensitivity-in-rats
#6
Fabiane Martins Barbosa, Danilo Cabral, Fernanda Kabadayan, Eduardo Fernandes Bondan, Maria de Fátima Monteiro Martins, Thiago Berti Kirsten, Leoni Villano Bonamin, Nicolle Queiroz-Hazarbassanov, Maria Martha Bernardi, Cintia Helena Coury Saraceni
OBJECTIVE: The present study evaluated the nociceptive response induced by dentin hypersensitivity after dental erosion in rats that were exhibited to unpredictable chronic mild stress (UCMS)-induced depressive-like behavior. DESIGN: Adult male rats were subjected to UCMS (depression [D] group) or not (no depression [ND] group) for 30days and received either acidic solution to induce dental erosion (E) or water (W), thus forming the WND, END, WD, and ED groups. After the end of treatment, depressive-like parameters (i...
April 15, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28425057/quantifying-synergies-in-two-versus-one-situations-in-team-sports-an-example-from-rugby-union
#7
P Passos, J Milho, C Button
Collective behaviors in team sports result in players forming interpersonal synergies that contribute to performance goals. Because of the huge amount of variables that continuously constrain players' behavior during a game, the way that these synergies are formed remain unclear. Our aim was to quantify interpersonal synergies in the team sport of Rugby Union. For that purpose we used the Uncontrolled Manifold Hypothesis (UCM) to identify interpersonal synergies that are formed between ball carrier and support player in two-versus-one situations in Rugby Union...
April 19, 2017: Behavior Research Methods
https://www.readbyqxmd.com/read/28423977/age-associated-differences-in-motor-output-variability-and-coordination-during-the-simultaneous-dorsiflexion-of-both-feet
#8
Amanda Marchini, Rafael Pereira, Wellington Pedroso, Evangelos Christou, Osmar Pinto Neto
Older adults are more variable than young adults on tasks that demand the simultaneous control of more than one effector, and the difference between age groups may be related to their different capacity of coordinating the force output of the involved effectors. The goal of this study was to determine whether age-associated differences in motor output variability during tasks involving the simultaneous dorsiflexion of two feet can be partially explained by differences in coordination and possibly attenuated by physical training...
April 19, 2017: Somatosensory & Motor Research
https://www.readbyqxmd.com/read/28421533/changes-in-the-prefrontal-glutamatergic-and-parvalbumin-systems-of-mice-exposed-to-unpredictable-chronic-stress
#9
Ryan Shepard, Laurence Coutellier
The prefrontal cortex (PFC) is highly sensitive to the effects of stress, a known risk factor of mood disorders including anxiety and depression. Abnormalities in PFC functioning have been well described in humans displaying stress-induced depressive symptoms, and hypoactivity of the PFC is now recognized to be a key feature of the depressed brain. However, little is known about the causes and mechanisms leading to this altered prefrontal functional activity in the context of stress-related mood disorders. We previously showed that unpredictable chronic mild stress (UCMS) in mice increases prefrontal expression of parvalbumin (PV), an activity-dependent calcium-binding albumin protein expressed in a specific subtype of GABAergic neurons, highlighting a potential mechanism through which chronic stress leads to hypofunction of the PFC...
April 18, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28388928/snpphena-a-corpus-for-extracting-ranked-associations-of-single-nucleotide-polymorphisms-and-phenotypes-from-literature
#10
Behrouz Bokharaeian, Alberto Diaz, Nasrin Taghizadeh, Hamidreza Chitsaz, Ramyar Chavoshinejad
BACKGROUND: Single Nucleotide Polymorphisms (SNPs) are among the most important types of genetic variations influencing common diseases and phenotypes. Recently, some corpora and methods have been developed with the purpose of extracting mutations and diseases from texts. However, there is no available corpus, for extracting associations from texts, that is annotated with linguistic-based negation, modality markers, neutral candidates, and confidence level of associations. METHOD: In this research, different steps were presented so as to produce the SNPPhenA corpus...
April 7, 2017: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/28382717/the-origin-of-aliphatic-hydrocarbons-in-olive-oil
#11
Manuel Pineda, María Rojas, Gregorio Gálvez-Valdivieso, Miguel Aguilar
BACKGROUND: There are many substances that can interfere with olive oil quality. Some of them are well characterized, but many others have an unknown origin. Saturated hydrocarbons make an extraordinary complex family of numerous molecules, some of them present naturally in vegetable oils. When major natural saturated hydrocarbons are analyzed by standard chromatographic methods, this complex mixture of saturated hydrocarbons appears as a hump in the chromatogram and is commonly named as unresolved complex mixture (UCM) whose origin remains unknown...
April 6, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28372242/green-synthesis-of-isomaltulose-from-cane-molasses-by-bacillus-subtilis-wb800-pha01-pali-in-a-biologic-membrane-reactor
#12
Lingtian Wu, Shanshan Wu, Juanjuan Qiu, Chuanxue Xu, Sha Li, Hong Xu
A green process and environmentally benign process is highly desirable in the development of enzymatic catalysis. In this work, the shuttle plasmid pHA01 was constructed and the sucrose isomerase (SIase) was expressed in Bacillus subtilis WB800. The optimal nitrogen and carbon sources for SIase expression were yeast extract (15g/L) and un-pretreated cane molasses (UCM, 20g/L), respectively. After the UCM fed, the whole cell activity reached 5.2U/mL in a 7.5L fermentor. Optimum catalytic temperature and pH of whole cell were 35°C and 5...
August 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28368835/lung-field-segmentation-in-chest-radiographs-from-boundary-maps-by-a-structured-edge-detector
#13
Wei Yang, Yunbi Liu, Liyan Lin, Zhaoqiang Yun, Zhentai Lu, Qianjin Feng, Wufan Chen
Lung field segmentation in chest radiographs (CXRs) is an essential preprocessing step in automatically analyzing such images. We present a method for lung field segmentation that is built on a high-quality boundary map detected by an efficient modern boundary detector, namely, a structured edge detector (SED). A SED is trained beforehand to detect lung boundaries in CXRs with manually outlined lung fields. Then, an ultrametric contour map (UCM) is transformed from the masked and marked boundary map. Finally, the contours with the highest confidence level in the UCM are extracted as lung contours...
March 27, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28331238/psychological-stress-and-coping-resources-during-primary-systemic-therapy-for-breast-cancer-results-of-a-prospective-study
#14
Volker Tschuschke, Georgios Karadaglis, Kalliopi Evangelou, Clara Gräfin von Schweinitz, Jürgen Schwickerath
Introduction This prospective study reports on the impact of psychological factors on women with primary breast cancer undergoing neoadjuvant chemotherapy. These women are in a special situation, where they not only have to deal with the shock of the cancer diagnosis but also with the fact that the malignant tumor will not be removed immediately but only after completing chemotherapy. A situation like this is stressful and requires a personal strength which not every woman may have. Methods In a prospective study 53 patients were assessed using various psychological and psycho-oncological questionnaires which aimed to evaluate their psychological stress and their coping resources...
February 2017: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/28293798/old-adults-preserve-motor-flexibility-during-rapid-reaching
#15
Christian Greve, Tibor Hortobágyi, Raoul M Bongers
PURPOSE: Our ability to flexibly coordinate the available degrees of freedom allows us to perform activities of daily living under various task constraints. Healthy old adults exhibit subclinical peripheral and central nervous system dysfunctions, possibly compromising the flexibility in inter-joint coordination during voluntary movements and the ability to adapt to varying task constraints. METHOD: We examined how healthy old (75.4 ± 5.2 years, n = 14) compared with young adults (24...
May 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28246971/bilateral-synergy-as-an-index-of-force-coordination-in-chronic-stroke
#16
Nyeonju Kang, James H Cauraugh
Dysfunction in bilateral coordination post-stroke is responsible for impaired bilateral movements. This study examined bilateral synergies using the uncontrolled manifold (UCM) approach while individuals in a chronic stage after stroke executed bilateral isometric force control at three submaximal force levels. Nine patients with stroke and nine age-matched healthy controls performed 24 trials of wrist and fingers extension at 5, 25, and 50% of MVC. The UCM findings revealed: (a) decreased bilateral synergies in patients with stroke as compared to controls at 50% of MVC and (b) reduced good variability and increased bad variability components in patients with stroke at 50% of MVC...
February 28, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28216134/spatial-distribution-and-composition-of-aliphatic-hydrocarbons-polycyclic-aromatic-hydrocarbons-and-hopanes-in-superficial-sediments-of-the-coral-reefs-of-the-persian-gulf-iran
#17
Ranjbar Jafarabadi Ali, Riyahi Bakhtiari Alireza, Aliabadian Mansour, Shadmehri Toosi Amirhossein
This study is the first quantitative report on petroleum biomarkers from the coral reefs systems of the Persian Gulf. 120 reef surface sediment samples from ten fragile coral reef ecosystems were collected and analyzed for grain size, biogenic elements, elemental ratios, and petroleum biomarkers (n-alkanes, PAHs(1) and Hopanes) to assess the sources and early diagenesis of sedimentary organic matter. The mean grain size of the reef sediments ranged from 13.56 to 37.11% (Clay), 26.92 to 51.73% (Sand) and 35...
February 16, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28152751/identifying-avoidable-terminal-oncology-icu-hospitalizations
#18
Andrew Hantel, Blase N Polite
56 Background: Eight percent of cancer patients expire in the ICU. There is no association between spending on aggressive end of life (EOL) care and survival outcomes. This aggressive care is also associated with reduced quality of life for patients and families. The National Quality Forum endorses the number of patients admitted to the ICU in the last 30 days of life as a quality of care measure. Our hypothesis is that a significant number of oncology patients suffer avoidable terminal ICU hospitalizations...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28143631/automatic-biological-cell-counting-using-a-modified-gradient-hough-transform
#19
Emmanuel Denimal, Ambroise Marin, Stéphane Guyot, Ludovic Journaux, Paul Molin
We present a computational method for pseudo-circular object detection and quantitative characterization in digital images, using the gradient accumulation matrix as a basic tool. This Gradient Accumulation Transform (GAT) was first introduced in 1992 by Kierkegaard and recently used by Kaytanli & Valentine. In the present article, we modify the approach by using the phase coding studied by Cicconet, and by adding a "local contributor list" (LCL) as well as a "used contributor matrix" (UCM), which allow for accurate peak detection and exploitation...
February 1, 2017: Microscopy and Microanalysis
https://www.readbyqxmd.com/read/28140544/h%C3%A3-ufigkeit-und-muster-der-tumorerkennung-nach-selbstuntersuchung-bei-mittel-bis-hochrisiko-melanompatienten
#20
Anca Sindrilaru, Vera Neckermann, Thomas Eigentler, Panagiotis Kampilafkos, Diana Crisan, Nicolai Treiber, Karin Scharffetter-Kochanek, Lars Alexander Schneider
HINTERGRUND UND ZIELSETZUNG: Die Frage, wie oft Melanompatienten mit Mittel- bis Hochrisikomelanomen den Tumor bemerken und welche Eigenerkennungsmuster existieren ist bislang nicht beantwortet. PATIENTEN UND METHODEN: Wir haben eine retrospektive Studie an Melanompatienten durchgeführt, die sich zwischen 2004 und 2008 einer Sentinellymphknotenbiopsie unterzogen haben,. Der Fragebogen wurde von 127 der insgesamt 133 Patienten ausgefüllt. ERGEBNISSE: 25 % bemerkten den Tumor überhaupt nicht...
January 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
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