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https://www.readbyqxmd.com/read/29783631/melatonin-analogue-antiproliferative-and-cytotoxic-effects-on-human-prostate-cancer-cells
#1
Angela Calastretti, Giuliana Gatti, Valeria Lucini, Silvana Dugnani, Gianfranco Canti, Francesco Scaglione, Annamaria Bevilacqua
Melatonin has been indicated as a possible oncostatic agent in different types of cancer, its antiproliferative role being demonstrated in several in vitro and in vivo experimental models of tumors. Specifically, melatonin was proven to inhibit cell growth of both androgen-dependent and independent prostate cancer cells, through various mechanisms. A number of melatonin derivatives have been developed and tested for their role in the prevention and treatment of neoplastic diseases. We recently proved the in vitro and in vivo anticancer activity of UCM 1037, a newly-synthetized melatonin analogue, on melanoma and breast cancer cells...
May 18, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29739367/impact-of-umbilical-cord-milking-and-pasteurized-donor-human-milk-on-necrotizing-enterocolitis-a-retrospective-review
#2
Mehtab K Sekhon, Bradley A Yoder
BACKGROUND: Necrotizing enterocolitis (NEC) is a serious complication of prematurity. Our objective was to evaluate the impact of an umbilical cord milking protocol (UCM) and pasteurized donor human milk (PDHM) on NEC rates in infants less than 30 weeks gestational age from January 1, 2010 to September 30, 2016. We hypothesized an incremental decrease in NEC after each intervention. METHODS: We performed a retrospective review of 638 infants born less than 30 weeks gestational age...
May 8, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29713912/flavobacterium-zaozhuangense-sp-nov-a-new-member-of-the-family-flavobacteriaceae-isolated-from-metolachlor-contaminated-soil
#3
Qing Chen, Hong-Mei Wang, Wen Zhuang, Zhong-Guan Sun, Jing Chen, Yan Ge, Ji-Guo Qiu, Jian He
Strain ZZ-8T , a Gram-negative, aerobic, non-spore-forming, non-motile, yellow-pigmented, rod-shaped bacterium, was isolated from metolachlor-contaminated soil in China. The taxonomic position was investigated using a polyphasic approach. Phylogenetic analysis based on 16S rRNA gene sequences revealed that strain ZZ-8T is a member of the genus Flavobacterium and shows high sequence similarity to Flavobacterium humicola UCM-46T (97.2%) and Flavobacterium pedocola UCM-R36T (97.1%), and lower (< 97%) sequence similarity to other known Flavobacterium species...
April 30, 2018: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29710597/impact-of-urbanization-related-land-use-land-cover-changes-and-urban-morphology-changes-on-the-urban-heat-island-phenomenon
#4
Xuefan Zhou, Hong Chen
Urban growth and development caused by urbanization influence the urban heat island (UHI) phenomenon. With the rapid development of urbanization, China's major cities are facing more serious climate change problems, especially the UHI phenomenon. Proper planning and urban design of compact cities may improve the ventilation of street canyons and change the heat balance in the urban canopy and thus mitigate the UHI phenomenon. The aim of this study is to evaluate and discuss the mitigation of UHI with different types of land-use and land-cover (LUCC), as well as different development patterns for compact cities...
April 24, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29698836/system-for-informatics-in-the-molecular-pathology-laboratory-simpl-an-open-source-end-to-end-solution-for-next-generation-sequencing-clinical-data-management
#5
Wenjun Kang, Sabah Kadri, Rutika Puranik, Michelle N Wurst, Sushant A Patil, Ibro Mujacic, Sonia Benhamed, Nifang Niu, Chao Jie Zhen, Bekim Ameti, Bradley C Long, Filipo Galbo, David Montes, Crystal Iracheta, Venessa L Gamboa, Daisy Lopez, Michael Yourshaw, Carolyn A Lawrence, Dara L Aisner, Carrie Fitzpatrick, Megan E McNerney, Y Lynn Wang, Jorge Andrade, Samuel L Volchenboum, Larissa V Furtado, Lauren L Ritterhouse, Jeremy P Segal
Next-generation sequencing (NGS) diagnostic assays are increasingly becoming the standard of care in oncology practice. As the scale of an NGS laboratory grows, management of these assays requires organizing large amounts of information, including patient data, laboratory processes, genomic data, as well as variant interpretation and reporting. Although several Laboratory Information Systems (LIS) and/or Laboratory Information Management Systems (LIMS) are commercially available, they may not meet all of the needs of a given laboratory, in addition to being frequently cost prohibitive...
April 23, 2018: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/29689422/consequences-of-a-double-hit-of-stress-during-the-perinatal-period-and-midlife-in-female-rats-mismatch-or-cumulative-effect
#6
Gilles Van Camp, Jenny Cigalotti, Hammou Bouwalerh, Jérôme Mairesse, Eleonora Gatta, Paola Palanza, Stefania Maccari, Sara Morley-Fletcher
The interplay between experiences during critical developmental periods and later adult life is crucial in shaping individual variability in stress coping strategies. Exposure to stressful events in early life has strongly programs an individual's phenotype and adaptive capabilities. Until now, studies on programming and reversal strategies in early life stress animal models have been essentially limited to males. By using the perinatal stress (PRS) rat model (a model more sensitive to aging changes) in middle-aged females, we investigated the behavioral and endocrine responses following exposure in later life to an unpredictable chronic mild stress (uCMS) condition for six weeks...
April 14, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29658926/evaluation-of-stem-cell-therapies-in-a-bilateral-patellar-tendon-injury-model-in-rats
#7
John R Wagner, Takashi Taguchi, Jane Y Cho, Chandrashekhar Charavaryamath, Dominique J Griffon
Regenerative medicine provides novel alternatives to conditions that challenge traditional treatments. The prevalence and morbidity of tendinopathy across species, combined with the limited healing properties of this tissue, have prompted the search for cellular therapies and propelled the development of experimental models to study their efficacy. Umbilical cord matrix-derived mesenchymal stem cells (UCM-MSC) are appealing candidates because they are abundant, easy to collect, circumvent the ethical concerns and risk of teratoma formation, yet resemble primitive embryonic stem cells more closely than adult tissue-derived MSCs...
March 30, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29626565/antidepressant-like-actions-by-silencing-of-neuronal-elav-like-rna-binding-proteins-hub-and-huc-in-a-model-of-depression-in-male-mice
#8
Maria Domenica Sanna, Alessandro Quattrone, Nicoletta Galeotti
Currently available antidepressant drugs often fail to achieve full remission and patients might evolve to treatment resistance, showing the need to achieve a better therapy of depressive disorders. Increasing evidence supports that post-transcriptional regulation of gene expression is important in neuronal development and survival and a relevant role is played by RNA binding proteins (RBP). To explore new therapeutic strategies, we investigated the role of the neuron-specific ELAV-like RBP (HuB, HuC, HuD) in a mouse model of depression...
April 4, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29564506/stability-of-steady-hand-force-production-explored-across-spaces-and-methods-of-analysis
#9
Paulo B de Freitas, Sandra M S F Freitas, Mechelle M Lewis, Xuemei Huang, Mark L Latash
We used the framework of the uncontrolled manifold (UCM) hypothesis and explored the reliability of several outcome variables across different spaces of analysis during a very simple four-finger accurate force production task. Fourteen healthy, young adults performed the accurate force production task with each hand on 3 days. Small spatial finger perturbations were generated by the "inverse piano" device three times per trial (lifting the fingers 1 cm/0.5 s and lowering them). The data were analyzed using the following main methods: (1) computation of indices of the structure of inter-trial variance and motor equivalence in the space of finger forces and finger modes, and (2) analysis of referent coordinates and apparent stiffness values for the hand...
March 22, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29561777/an-internet-of-things-system-for-underground-mine-air-quality-pollutant-prediction-based-on-azure-machine-learning
#10
ByungWan Jo, Rana Muhammad Asad Khan
The implementation of wireless sensor networks (WSNs) for monitoring the complex, dynamic, and harsh environment of underground coal mines (UCMs) is sought around the world to enhance safety. However, previously developed smart systems are limited to monitoring or, in a few cases, can report events. Therefore, this study introduces a reliable, efficient, and cost-effective internet of things (IoT) system for air quality monitoring with newly added features of assessment and pollutant prediction. This system is comprised of sensor modules, communication protocols, and a base station, running Azure Machine Learning (AML) Studio over it...
March 21, 2018: Sensors
https://www.readbyqxmd.com/read/29560744/formulation-and-evaluation-of-nano-lipid-formulation-containing-cns-acting-drug-molecular-docking-in-vitro-assessment-and-bioactivity-detail-in-rats
#11
Mahtab Alam, Abul Kalam Najmi, Iqbal Ahmad, Farhan Jalees Ahmad, Md Jawaid Akhtar, Syed Sarim Imam, Mohd Akhtar
The study performed molecular docking, formulated, characterized thymoquinone (TQ) loaded solid lipid nano particles (TQSLN) and exhibited comparative antidepressant activity. TQ loaded nano lipid formulations were prepared by solvent injection methods and characterize for different in-vitro parameters. The optimized formulation was evaluated for depression using unpredictable chronic mild stress (UCMS) model for a period of six weeks. TQSLN was assessed in modified forced swim test (MFST), tail suspension test (TST), locomotor activity followed by biochemical parameters such as monoaminesand brain derived neurotrophic factor (BDNF)...
March 21, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29538008/toll-like-receptor-4-deficient-mice-do-not-develop-remifentanil-induced-mechanical-hyperalgesia-an-experimental-randomised-animal-study
#12
Delia Aguado, Rocío Bustamante, Ignacio A Gómez de Segura
BACKGROUND: Drugs with antagonistic actions on the Toll-like receptor 4 (Tlr4), such as naloxone at ultra low doses, have been used to inhibit opioid-induced hyperalgesia in rodents suggesting the involvement of this receptor and pathway on opioid-induced hyperalgesia. OBJECTIVE: The aim of this study was to determine whether mice without the Tlr4 gene (Tlr4) would not develop remifentanil-induced hyperalgesia. DESIGN: An experimental randomised animal study...
March 13, 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29535993/placental-transfusion-and-cardiovascular-instability-in-the-preterm-infant
#13
REVIEW
Zbynĕk Straňák, Simona Feyereislová, Peter Korček, Eugene Dempsey
Postnatal adaptation in preterm newborn comprises complex physiological processes that involve significant changes in the circulatory and respiratory system. Increasing hemoglobin level and blood volume following placental transfusion may be of importance in enhancing arterial oxygen content, increasing cardiac output, and improving oxygen delivery. The European consensus on resuscitation of preterm infants recommends delayed cord clamping (DCC) for at least 60 s to promote placenta-fetal transfusion in uncompromised neonates...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29532100/multi-finger-synergies-and-the-muscular-apparatus-of-the-hand
#14
Cristian Cuadra, Angelo Bartsch, Paula Tiemann, Sasha Reschechtko, Mark L Latash
We explored whether the synergic control of the hand during multi-finger force production tasks depends on the hand muscles involved. Healthy subjects performed accurate force production tasks and targeted force pulses while pressing against loops positioned at the level of fingertips, middle phalanges, and proximal phalanges. This varied the involvement of the extrinsic and intrinsic finger flexors. The framework of the uncontrolled manifold (UCM) hypothesis was used to analyze the structure of inter-trial variance, motor equivalence, and anticipatory synergy adjustments prior to the force pulse in the spaces of finger forces and finger modes (hypothetical finger-specific control signals)...
May 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29500451/increased-spatial-variability-and-intensification-of-extreme-monsoon-rainfall-due-to-urbanization
#15
Supantha Paul, Subimal Ghosh, Micky Mathew, Anjana Devanand, Subhankar Karmakar, Dev Niyogi
While satellite data provides a strong robust signature of urban feedback on extreme precipitation; urbanization signal is often not so prominent with station level data. To investigate this, we select the case study of Mumbai, India and perform a high resolution (1 km) numerical study with Weather Research and Forecasting (WRF) model for eight extreme rainfall days during 2014-2015. The WRF model is coupled with two different urban schemes, the Single Layer Urban Canopy Model (WRF-SUCM), Multi-Layer Urban Canopy Model (WRF-MUCM)...
March 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29492588/anticipatory-coarticulation-in-non-speeded-arm-movements-can-be-motor-equivalent-carry-over-coarticulation-always-is
#16
Eva Hansen, Britta Grimme, Hendrik Reimann, Gregor Schöner
In a sequence of arm movements, any given segment could be influenced by its predecessors (carry-over coarticulation) and by its successor (anticipatory coarticulation). To study the interdependence of movement segments, we asked participants to move an object from an initial position to a first and then on to a second target location. The task involved ten joint angles controlling the three-dimensional spatial path of the object and hand. We applied the principle of the uncontrolled manifold (UCM) to analyze the difference between joint trajectories that either affect (non-motor equivalent) or do not affect (motor equivalent) the hand's trajectory in space...
May 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29475242/a-12-week-multi-domain-lifestyle-modification-to-reduce-depressive-symptoms-in-older-adults-a-preliminary-report
#17
Ki Jung Chang, Chang Hyung Hong, Hyun Woong Roh, Kang Soo Lee, Eun Hee Lee, Jinju Kim, Hyun Kook Lim, Sang Joon Son
OBJECTIVE: The objective of this study was to compare the effectiveness of usual care management (UCM) and a newly-developed lifestyle modification with contingency management (LMCM) for geriatric depressive symptoms in the community. METHODS: A randomized controlled trial was conducted in 93 older adults with major depressive disorder at community mental health centers. A 12 week multi-domain LMCM was developed by providing positive reinforcement using 'gold medal stickers' as a symbolic incentive to motivate their participation and adherence...
March 2018: Psychiatry Investigation
https://www.readbyqxmd.com/read/29460414/tissue-engineering-of-human-knee-meniscus-using-functionalized-and-reinforced-silk-polyvinyl-alcohol-composite-three-dimensional-scaffolds-understanding-the-in-vitro-and-in-vivo-behavior
#18
Mamatha Muraleedharan Pillai, Janarthanan Gopinathan, Rathinasamy Senthil Kumar, Gopal Sathish Kumar, Sivanandam Shanthakumari, Kulasekaran Santosh Sahanand, Amitava Bhattacharyya, Rajendran Selvakumar
Tissue engineered constructs with rapid restoration of mechanical and biological properties remain a challenge, emphasizing the need to develop novel scaffolds. Here, we present a multicomponent composite three-dimensional scaffold structure with biomimetic reinforcement and biomolecule functionalization for meniscus tissue engineering. The scaffold structure was developed using 3:1 silk fibroin (SF) and polyvinyl alcohol (PVA). Autoclaved eggshell membrane (AESM) powder (1-3%w/v) was used as reinforcement to enhance biomechanical properties...
June 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29451821/protection-from-vascular-dysfunction-in-female-rats-with-chronic-stress-and-depressive-symptoms
#19
Steven D Brooks, Stan Hileman, Paul D Chantler, Samantha Milde, Kent A Lemaster, Stephanie Frisbee, J Kevin Shoemaker, Dwayne N Jackson, Jefferson C Frisbee
The increasing prevalence and severity of clinical depression is strongly correlated with vascular disease risk, creating a comorbid condition with poor outcomes, although demonstrating a sexual disparity where females are at lower risk than males for subsequent cardiovascular events. To determine potential mechanisms responsible for this protection against stress/depression-induced vasculopathy in females, we exposed male and female ({plus minus}ovariectomy) rats to the unpredictable chronic mild stress (UCMS) model for 8 weeks and determined depressive symptom severity, vascular reactivity in aortic rings (AR) and ex vivo middle cerebral arteries (MCA), and determined the profile of major metabolites regulating vascular tone...
February 16, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29451819/protection-from-chronic-stress-and-depressive-symptom-induced-vascular-endothelial-dysfunction-in-female-rats-is-abolished-by-preexisting-metabolic-disease
#20
Steven D Brooks, Stanley M Hileman, Paul D Chantler, Samantha A Milde, Kent A Lemaster, Stephanie J Frisbee, J Kevin Shoemaker, Dwayne N Jackson, Jefferson C Frisbee
While it is known that chronic stress and clinical depression are powerful predictors of poor cardiovascular outcomes, recent clinical evidence has identified correlations between the development of metabolic disease and depressive symptoms, creating a combined condition of severely elevated cardiovascular disease risk. In this study, we used the obese Zucker rat (OZRs) and the unpredictable chronic mild stress (UCMS) model to determine the impact of preexisting metabolic disease on the relationship between chronic stress/depressive symptoms and vascular function...
May 1, 2018: American Journal of Physiology. Heart and Circulatory Physiology
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