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M Ayyub, A K Najmi, M Akhtar
Objective: Oxidative stress and alternation of renin-angiotensin system has been implicated in the pathophysiology of various cardio vascular, endocrine including mood and anxiety disorders. The present study evaluated the role of irbesartan in stress induced different models of depression. Materials and method: Mice were treated with irbesartan (40 mg/kg), fluoxetine (25 mg/kg) alone in combination orally. Drugs treatment started after 2 weeks from the beginning of the unpredictable mild stress (UCMS) protocol...
October 18, 2016: Drug Research
Pedro J Sanches Filho, Emerson M Böhm, Giani M B Böhm, Gissele O Montenegro, Lucas A Silveira, Glauco R Betemps
A high concentration of hydrocarbons in the environment is indicative of pollution. To evaluate the effect of hydrocarbons transported by urban runoff, the present study analyzed total petroleum hydrocarbons (TPHs), aliphatic hydrocarbons (AHs), unresolved complex mixture (UCM), and n-alkanes of the sediments of the canal that cross the urban area of Pelotas, Rio Grande do Sul, Brazil. The carbon preference index (CPI), terrigenous/aquatic ratio (TAR), and pristane/phytane ratio were determined. The TPH content ranged from 177,043...
October 11, 2016: Marine Pollution Bulletin
Ning Wang, Sheng-Guang Li, Xiao-Xiao Lin, Yuan-Lin Su, Wei-Jing Qi, Jin-Yan Wang, Fei Luo
Although previous studies have suggested that depression may be associated with inhibition of evoked pain but facilitation of spontaneous pain, the mechanisms underlying these relationships are unclear. The present study investigated whether the difference between evoked and spontaneous pain on sensory (descending inhibition) and affective (avoidance motivation) components contributes to the divergent effects of depression on them. Depressive-like behavior was produced in male Wistar rats by unpredictable chronic mild stress (UCMS)...
2016: Frontiers in Behavioral Neuroscience
Hannah Wenger, Adam B Weiner, Aria Razmaria, Gladell P Paner, Scott E Eggener
INTRODUCTION: Several institutional studies have suggested that pathological Gleason score≤6 prostate cancer has little or no capacity for metastasis. MATERIALS AND METHODS: Using the Surveillance, Epidemiology, and End Results database (SEER, 2004-2011, n = 19,594) and the National Cancer Database (NCDB, 2004-2013, n = 57,540), we identified patients with pathological Gleason score≤6 prostate cancer following radical prostatectomy and lymph node dissection...
September 27, 2016: Urologic Oncology
Y Qiu, J Guo, R Mao, K Chao, B-L Chen, Y He, Z-R Zeng, S-H Zhang, M-H Chen
Toll-like receptor-3 (TLR3) priming may enhance mesenchymal stem cell (MSC) immunosuppressive activity, but this mechanism has not been investigated in the context of inflammatory bowel disease. Thus, we assessed the immunosuppressive properties of TLR3-primed MSCs using a trinitrobenzene sulfonate (TNBS)-induced mouse model of colitis. Intraperitoneally injected polyribocytidylic acid (poly (I:C)- (a ligand of TLR3) primed human umbilical cord-derived MSCs (hUC-MSCs) migrated to the inflamed colon and effectively improved clinical and pathological manifestations in colitic mice compared with mice treated with unstimulated hUC-MSCs (UCMs)...
September 21, 2016: Mucosal Immunology
Daniele Claudino Maciel, José Roberto Botelho de Souza, Satie Taniguchi, Márcia Caruso Bícego, Carlos Augusto França Schettini, Eliete Zanardi-Lamardo
Estuaries generally act as sediment traps and may retain a range of contaminants associated to this matrix. Aliphatic hydrocarbons (AHs) were investigated in Capibaribe Estuarine System and adjacent shelf, Northeast of Brazil, to evaluate the contamination and to better understand its functionality related to the coast. Fourteen sediment samples were analyzed, using gas chromatography with flame ionization detection. Total AHs concentrations ranged from 7.5 to 190.3μgg(-1) and n-alkanes ranged from below detection limit (<DL) to 9...
August 29, 2016: Marine Pollution Bulletin
Rosa M Ortega Anta
En el presente suplemento de la revista Nutrición Hospitalaria se resumen las conferencias presentadas en las Terceras Jornadas UCMASEN (Universidad Complutense de Madrid - Asociación de Estudios Nutricionales), bajo el título "Nutrición como estrategia en la mejora y promoción de la salud", que se celebraron durante los días 3 y 4 de febrero de 2016 en la Facultad de Farmacia de la Universidad Complutense de Madrid. Estas Jornadas han sido una actividad promovida por el grupo de investigación UCM-VALORNUT y han contado con el apoyo institucional de la Fundación Española de la Nutrición (FEN)...
2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Shivam Agarwal, Vijay Jaiswal, Dharamveer Singh, Prateek Jaiswal, Amit Garg, Amit Upadhyay
AIM: Placental redistribution has been shown to improve haematological outcomes in the immediate neonatal period and early infancy. This study compared the effects of delayed cord clamping (DCC) and umbilical cord milking (UCM) on haematological and growth parameters at 12 months of age. METHODS: This was a follow-up study of a randomised control trial, conducted in a tertiary care paediatric centre from August 2013 to August 2014. We studied 200 apparently healthy Indian infants randomised at birth to receive DCC for 60-90 seconds or UCM...
November 2016: Acta Paediatrica
Jinhua Wang, Jie Yuan, Jingjuan Pang, Jiang Ma, Bing Han, Yuan Geng, Li Shen, Hualong Wang, Qinying Ma, Yanyong Wang, Mingwei Wang
BACKGROUND/AIMS: Chronic stress can lead to cognitive impairment. Senescence-accelerated mouse prone 8 (SAMP8) is a naturally occurring animal model that is useful for investigating the neurological mechanisms of Alzheimer's disease. Here we investigated the impact and mechanisms of chronic stress on cognition in male SAMP8 mice. METHODS: Male 6-month- old SAMP8 and SAMR1 (senescence-accelerated mouse resistant 1) mice strains were randomly divided into 4 groups...
2016: Cellular Physiology and Biochemistry
Shunta Togo, Hiroshi Imamizu
We grasp and dexterously manipulate an object through multi-digit synergy. In the framework of the uncontrolled manifold (UCM) hypothesis, multi-digit synergy is defined as the coordinated control mechanism of fingers to stabilize variable important for task success, e.g., total force. Previous studies reported anticipatory synergy adjustments (ASAs) that correspond to a drop of the synergy index before a quick change of the total force. The present study compared ASA's properties with individual performances of feedforward force control to investigate a relationship of those...
October 6, 2016: Neuroscience Letters
Dong-Sheng Wang, Jing Han, Shuo Li, Ting Sun, Yan-Yan Guo, Wen-Bo Kang, Zhen Tian, Jian-Ning Zhao, Gang Liu, Shui-Bing Liu, Ming-Gao Zhao
Activation of translocator protein (18 kDa) (TSPO) plays an important role to mediate rapid anxiolytic efficacy in stress response and stress-related disorders by the production of neurosteroids. However, little is known about the ligand of TSPO on the anxiety-like and depressive behaviors and the underlying mechanisms in chronic unpredictable mild stress (UCMS) mice. In the present study, a novel ligand of TSPO, ZBD-2 [N-benzyl-N-ethyl-2-(7,8-dihydro-7-benzyl-8-oxo-2-phenyl-9H-purin-9-yl) acetamide] synthesized by our laboratory, was used to evaluate the anxiolytic and antidepressant efficacy and to elucidate the underlying mechanisms...
August 20, 2016: Neuromolecular Medicine
Shunta Togo, Takahiro Kagawa, Yoji Uno
The brain must coordinate with redundant bodies to perform motion tasks. The aim of the present study is to propose a novel control model that predicts the characteristics of human joint coordination at a behavioral level. To evaluate the joint coordination, an uncontrolled manifold (UCM) analysis that focuses on the trial-to-trial variance of joints has been proposed. The UCM is a nonlinear manifold associated with redundant kinematics. In this study, we directly applied the notion of the UCM to our proposed control model called the "UCM reference feedback control...
2016: Frontiers in Computational Neuroscience
Niveen Fulcher, Steven Tran, Soaleha Shams, Diptendu Chatterjee, Robert Gerlai
Unpredictable chronic mild stress (UCMS) and developmental social isolation are often utilized in laboratory animals to mimic unpredictable life stressors and early life adversity that may contribute to the development of major depressive disorder in humans. Zebrafish (Danio rerio) have been used to examine the effects of both developmental social isolation and UCMS. However, anxiety-like behavioral responses, social behavior, and neurochemical changes induced by stressors have not been well characterized. Furthermore, the possible interaction between UCMS and developmental isolation remains unexplored...
July 25, 2016: Zebrafish
Ana Cabrerizo, Pablo Tejedo, Jordi Dachs, Javier Benayas
Two Antarctic expeditions (in 2009 and 2011) were carried out to assess the local and remote anthropogenic sources of aliphatic and aromatic hydrocarbons, as well as potential biogenic hydrocarbons. Polycyclic aromatic hydrocarbons (PAHs), n-alkanes, biomarkers such as phytane (Ph) and pristane (Pr), and the aliphatic unresolved complex mixture (UCM), were analysed in soil and vegetation samples collected at Deception, Livingston, Barrientos and Penguin Islands (South Shetland Islands, Antarctica). Overall, the patterns of n-alkanes in lichens, mosses and grass were dominated by odd-over-even carbon number alkanes...
November 1, 2016: Science of the Total Environment
António M de Soure, Ana Fernandes-Platzgummer, Francisco Moreira, Carla Lilaia, Shi-Hwei Liu, Chen-Peng Ku, Yi-Feng Huang, William Milligan, Joaquim M S Cabral, Cláudia L da Silva
Umbilical cord matrix (UCM)-derived mesenchymal stem/stromal cells (MSCs) are promising therapeutic candidates for regenerative medicine settings. UCM MSCs have advantages over adult cells as these can be obtained through a non-invasive harvesting procedure and display a higher proliferative capacity. However, the high cell doses required in the clinical setting make large-scale manufacturing of UCM MSCs mandatory. A commercially available human platelet lysate-based culture supplement (UltraGRO(TM) , AventaCell BioMedical) (5%(v/v)) was tested to effectively isolate UCM MSCs and to expand these cells under (1) static conditions, using planar culture systems and (2) stirred culture using plastic microcarriers in a spinner flask...
July 22, 2016: Journal of Tissue Engineering and Regenerative Medicine
Evelina L Zdorovenko, Alexandra A Kadykova, Liudmyla D Varbanets, Alexander S Shashkov, Elena A Kiprianova, Oksana S Brovarskaya, Yuriy A Knirel
O-specific polysaccharide was obtained from the lipopolysaccharide of Pseudomonas chlororaphis subsp. chlororaphis UCM B-106 and studied by composition analysis along with 1D and 2D (1)H and (13)C NMR spectroscopy. The polysaccharide was found to contain a derivative of pseudaminic acid (Pse) and the following structure of the trisaccharide repeating unit was established: →4)-β-Psep5Ac7Hb-(2 → 6)-β-d-Galf-(1 → 3)-β-d-Galp-(1→ where Pse5Ac7Hb indicates 5-acetamido-3,5,7,9-tetradeoxy-7-[(R)-3-hydroxybutanoylamino]-l-glycero-l-manno-non-2-ulosonic acid...
October 4, 2016: Carbohydrate Research
Qamar M Sheikh, Derek Gatherer, Pedro A Reche, Darren R Flower
MOTIVATION: Influenza A viral heterogeneity remains a significant threat due to unpredictable antigenic drift in seasonal influenza and antigenic shifts caused by the emergence of novel subtypes. Annual review of multivalent influenza vaccines targets strains of influenza A and B likely to be predominant in future influenza seasons. This does not induce broad, cross protective immunity against emergent subtypes. Better strategies are needed to prevent future pandemics. Cross-protection can be achieved by activating CD8+ and CD4+ T cells against highly-conserved regions of the influenza genome...
July 10, 2016: Bioinformatics
D J Griffon, J Cho, J R Wagner, C Charavaryamath, J Wei, A Wagoner Johnson
Chitosan opens new perspectives in regenerative medicine as it enhances the properties of mesenchymal stem cells (MSCs) through formation of spheroids. Hypoxia has also been proposed to enhance stemness and survival of MSCs after in vivo implantation. These characteristics are relevant to the development of an off-the-shelf source of allogenic cells for regenerative therapy of tendinopathies. Umbilical cord-derived MSCs (UCM-MSCs) offer an abundant source of immature and immunoprivileged stem cells. In this study, equine UCM-MSCs (eqUCM-MSCs) conditioned for 3 and 7 days on chitosan films at 5% oxygen were compared to eqUCM-MSCs under standard conditions...
2016: Stem Cells International
Fuzhi Zhuang, Mei Li, Xin Gao, Yun Wang, Dongdong Wang, Xing Ma, Tengfei Ma, Shuling Gu
Alarin is a newly derived neuropeptide from a splice variant of the galanin-like peptide gene. We previously showed that alarin has an antidepressant-like effect by increasing the activity of the extracellular signal-regulated kinase (ERK) and protein kinase B (AKT) pathways, mediated by the tropomyosin-related kinase B receptor in the unpredictable chronic mild stress (UCMS) mouse model. Administration of rapamycin, a mammalian target of rapamycin (mTOR) inhibitor, prevents the rapid antidepressant-like effect induced by ketamine in animal models, indicating a vital role of mTOR in depression pathophysiology...
October 15, 2016: Behavioural Brain Research
Golshan Shirneshan, Alireza Riyahi Bakhtiari, Mahmoud Memariani
In 2012, a significant number of tar balls occurred along the Southwest coasts of the Caspian Sea (Iran). Several oil fields of Turkmenistan, Azerbaijan and Iran might be sources of oil spills and lead to the formation of these tar balls. For source identification, 6 tar ball samples were collected from the Southwest beaches of the Caspian Sea and subjected to fingerprint analysis based on the distribution of the source-specific biomarkers of pentacyclic tri-terpanes and steranes. Comparing the diagenic ratios revealed that the tar balls were chemically similar and originated from the same source...
October 15, 2016: Science of the Total Environment
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