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https://www.readbyqxmd.com/read/28926614/effect-of-chronic-stress-on-running-wheel-activity-in-mice
#1
Evan DeVallance, Dale Riggs, Barbara Jackson, Travis Parkulo, Stanley Zaslau, Paul D Chantler, I Mark Olfert, Randy W Bryner
Acute and chronic stress have been reported to have differing effects on physical activity in rodents, but no study has examined a chronic stress protocol that incorporates stressors often experienced by rodents throughout a day. To examine this, the effects of the Unpredictable Chronic Mild Stress (UCMS) protocol on voluntary running wheel activity at multiple time points, and/or in response to acute removal of chronic stress was determined. Twenty male Balb/c mice were given access and accustomed to running wheels for 4 weeks, after which they were randomized into 2 groups; exercise (EX, n = 10) and exercise with chronic stress using a modified UCMS protocol for 7 hours/day (8:00 a...
2017: PloS One
https://www.readbyqxmd.com/read/28921671/methyl-jasmonate-ameliorates-unpredictable-chronic-mild-stress-induced-behavioral-and-biochemical-alterations-in-mouse-brain
#2
Adaeze Adebesin, Abayomi M Ajayi, Elizabeth O Olonode, Osarume Omorogbe, Solomon Umukoro
Preclinical Research The effects of methyl jasmonate (MJ; 5, 10, 20 mg/kg, i.p), a natural product widely used for the relief of stress, depression, and exhaustion on unpredictable chronic mild stress (UCMS)-induced depression-like behaviors in mice was assessed and compared to those of imipramine (IMP; 10 mg/kg, i.p). MJ and IMP were given 30 min before exposure to UCMS with the procedure repeated daily for 2 weeks; 24 h after the stress session, the tail suspension test (TST) and sucrose preference test were assessed...
September 17, 2017: Drug Development Research
https://www.readbyqxmd.com/read/28890366/increasing-adult-hippocampal-neurogenesis-in-mice-after-exposure-to-unpredictable-chronic-mild-stress-may-counteract-some-of-the-effects-of-stress
#3
Luka Culig, Alexandre Surget, Marlene Bourdey, Wahid Khemissi, Anne-Marie Le Guisquet, Elise Vogel, Amar Sahay, René Hen, Catherine Belzung
Major depression is hypothesized to be associated with dysregulations of the hypothalamic-pituitary-adrenal (HPA) axis and impairments in adult hippocampal neurogenesis. Adult-born hippocampal neurons are required for several effects of antidepressants and increasing the rate of adult hippocampal neurogenesis (AHN) before exposure to chronic corticosterone is sufficient to protect against its harmful effects on behavior. However, it is an open question if increasing AHN after the onset of chronic stress exposure would be able to rescue behavioral deficits and which mechanisms might be involved in recovery...
September 7, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28875366/saikosaponin-d-relieves-unpredictable-chronic-mild-stress-induced-depressive-like-behavior-in-rats-involvement-of-hpa-axis-and-hippocampal-neurogenesis
#4
Hong-Yan Li, Ying-Hua Zhao, Min-Jie Zeng, Fang Fang, Min Li, Ting-Ting Qin, Lu-Yu Ye, Hong-Wei Li, Rong Qu, Shi-Ping Ma
RATIONALE: Saikosaponin D (SSD), a major bioactive component isolated from Radix Bupleuri, has been reported to exert neuroprotective properties. OBJECTIVES: The present study was designed to investigate the anti-depressant-like effects and the potential mechanisms of SSD. METHODS: Behavioural tests including sucrose preference test (SPT), open field test (OFT) and forced swim test (FST) were performed to study the antidepressant-like effects of SSD...
September 5, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28869185/gait-variability-and-motor-control-in-patients-with-knee-osteoarthritis-as-measured-by-the-uncontrolled-manifold-technique
#5
Gwenllian Fflur Tawy, Philip Rowe, Leela Biant
Knee osteoarthritis (OA) causes pain, reduced muscular strength and stiffness of the affected joint. In response, the motor control mechanism is altered, potentially compromising stability during acts of daily living. Reduced walking stability can be quantified in terms of gait variability. This study therefore aimed to identify and quantify the effects of knee arthritis on gait variability. Fifty adults (25 males/25 females) with end-stage OA of the knee sufficiently symptomatic to require joint replacement, walked on a self-paced treadmill for 2min...
August 18, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28859148/stellate-ganglion-block-attenuates-chronic-stress-induced-depression-in-rats
#6
Weiwei Wang, Weidong Shi, Hua Qian, Xijin Deng, Tong Wang, Wenzhi Li
BACKGROUND: Stress is a significant factor in the etiology of depression. Stellate ganglion block (SGB) has been shown to maintain the stability of the autonomic system and to affect the neuroendocrine system, including the hypothalamic-pituitary-adrenal (HPA) axis. The objective of this study was to determine the antidepressant-like effects of SGB on the autonomic system and the HPA axis, apoptosis-related proteins, related spatial learning and memory impairment, and sensorimotor dysfunction...
2017: PloS One
https://www.readbyqxmd.com/read/28852669/decreasing-incidence-of-skin-and-soft-tissue-infections-with-a-seasonal-pattern-at-an-academic-medical-center-2006-2014
#7
Ethan Morgan, Robert S Daum, Michael Z David
Background.  The incidence of skin and soft tissue infections (SSTIs) in the United States increased sharply after 2000 with the emergence of USA300 methicillin-resistant Staphylococcus aureus. We examined trends in SSTI incidence in 2006-2014 at the University of Chicago Medicine (UCM). Methods.  Data were obtained for patient encounters at UCM with an International Classification of Diseases, Ninth Revision-coded SSTI diagnosis between January 1, 2006 and March 31, 2014. Incidence density was calculated per 1000 encounters by quarter and year...
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28810562/anti-depressant-like-effects-of-jieyu-chufan-capsules-in-a-mouse-model-of-unpredictable-chronic-mild-stress
#8
Hui Zhao, Bingyu Liang, Linjie Yu, Yun Xu
Jieyu chufan (JYCF) is a well-known Chinese traditional medicine used for depression; however, the molecular mechanism underlying its anti-depressant action has remained elusive. In the present study, the anti-depressant effects of JYCF and the potential mechanisms were investigated in a mouse model. Five groups of 12 C57BL/6 mice each were used in the study, including a normal control group (NC group), a model control group (MC group) and three groups, which received different doses of JYCF (1.25, 2.5 and 5 g/kg) orally for 21 days (JYCF groups)...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28809147/flavobacterium-flaviflagrans-sp-nov-a-bacterium-of-the-family-flavobacteriaceae-isolated-from-forest-soil
#9
Ram Hari Dahal, Dhiraj Kumar Chaudhary, Jaisoo Kim
Two strains of bacteria designated CB-3T and CB-31 were isolated from Kyonggi University forest soil. Cells were aerobic, Gram-stain-negative, oxidase-positive, non-motile, non-spore-forming, rod-shaped and yellow-pigmented. They were able to grow at 15-42 °C, pH 5.5-9.5 and with 0-1.5 % (w/v) NaCl concentration. Flexirubin-type pigments were absent. Phylogenetic analysis based on 16S rRNA gene sequences revealed that strains CB-3T and CB-31 formed a lineage within the family Flavobacteriaceae of the phylum Bacteroidetes that was distinct from various species of the genus Flavobacterium, including Flavobacterium humicola UCM-46T (99...
August 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28803118/complex-interactions-between-the-subject-factors-of-biological-sex-and-prior-histories-of-binge-drinking-and-unpredictable-stress-influence-behavioral-sensitivity-to-alcohol-and-alcohol-intake
#10
Sema G Quadir, Eugenie Guzelian, Mason A Palmer, Douglas L Martin, Jennifer Kim, Karen K Szumlinski
Alcohol use disorders, affective disorders and their comorbidity are sexually dimorphic in humans. However, it is difficult to disentangle the interactions between subject factors influencing alcohol sensitivity in studies of humans. Herein, we combined murine models of unpredictable, chronic, mild stress (UCMS) and voluntary binge-drinking to examine for sex differences in the interactions between prior histories of excessive ethanol-drinking and stress upon ethanol-induced changes in motor behavior and subsequent drinking...
August 9, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28782590/may-the-use-of-different-background-strains-strain-the-stress-related-phenotype-of-gr-mice
#11
Miriam A Vogt, Natascha Pfeiffer, Anne Marie Le Guisquet, Christiane Brandwein, Bruno Brizard, Peter Gass, Catherine Belzung, Sabine Chourbaji
Genetically altered mice are available on different background strains. While respective backcrosses are often performed for pragmatic reasons, e.g. references, comparability, or existing protocols, the interaction between the mutations per se and the background strain often remains a neglected factor. The heterozygous mutation of the glucocorticoid receptor gene (GR) represents a well-examined model for depressive-like behavior in mice. To address the question in how far a robust depressive-like phenotype on a distinct background strain may allow a generalized conclusion, we analyzed respective phenotypes in two commonly used inbred strains: i...
August 3, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28712771/characterization-and-ecological-risk-of-polycyclic-aromatic-hydrocarbons-pahs-and-n-alkanes-in-sediments-of-shadegan-international-wetland-the-persian-gulf
#12
Akram Bemanikharanagh, Alireza Riyahi Bakhtiari, Jahangard Mohammadi, Ruhollah Taghizadeh-Mehrjardi
The distribution and sources of PAHs and n-alkanes were determined in the surface sediments from 202 locations in Shadegan international wetland with 537,700ha. The concentrations of total n-alkanes and PAHs ranged from 395.3 to 14933.46μgg(-1)dw and 593.74 to 53393.86ngg(-1)dw, respectively. Compared with other worldwide surveys, the concentration and contamination of sedimentary hydrocarbons were classified very high. A common petrogenic hydrocarbon source was strongly suggested in all sites by n-alkanes' profile with a Cmax at n-C20, Pr/Ph and CPI ratios<1 in all sites, and high percentage of UCM...
July 13, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28711771/toxicity-of-organic-compounds-from-unresolved-complex-mixtures-ucms-to-primary-fish-hepatocytes
#13
Karina Petersen, Maria T Hultman, Steven J Rowland, Knut Erik Tollefsen
Many environmental matrices contaminated with organic pollutants derived from crude oil or degraded petroleum contain mixtures so complex that they are typically unresolved by conventional analytical techniques such as gas chromatography. The resulting chromatographic features have become known as 'humps' or unresolved complex mixtures (UCMs). These UCMs often dominate the organic contaminants of polluted environmental samples: for example, in oil sands produced water up to 150mgL(-1) of 'naphthenic acids' appear as UCMs when examined by gas chromatography as the esters...
September 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28705628/characteristics-and-sources-of-anthropogenic-and-biogenic-hydrocarbons-in-sediments-from-the-coast-of-qatar
#14
Ahmed I Rushdi, Ismail Al-Shaikh, Aarif H El-Mubarak, Hajer A J A Alnaimi, Noora Al-Shamary, Hassan M Hassan, Mazen Abou Assali
Surface sediment samples from the coastal zone of Qatar were collected and analyzed to determine the characteristics, and sources of anthropogenic and biogenic hydrocarbons. The main compounds in these surface sediments included n-alkanes, methyl n-alkanoates, diterpenoids, hopanes, steranes, phthalate esters, polycyclic aromatic hydrocarbons (PAHs) and unresolved complex mixture (UCM). Their total concentrations ranged from 18.7±3.7-81.1±7.5ng/g (3.7±0.6-10.4±4.8%) for n-alkanes, 8.3±2.3-51±3.4ng/g (3...
July 10, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28686894/identification-of-weathered-multiple-petroleum-products-in-contaminated-soils-by-characterizing-unresolved-complex-mixture-hump-in-gas-chromatograph-data
#15
Soo-Kyung Jeon, Dongwook Kwon, Seunghak Lee
A new method for identifying the petroleum products in contaminated soils is presented, which characterizes the unresolved complex mixture (UCM) hump in the baseline of gas chromatograph (GC) data. The UCM hump identified in soil data was fitted to the Gaussian function, and characterized according to the time for the maximum point (TUCM) and the width of the hump (w). Experimental results showed that a UCM hump should be clearly observed in soils when contaminated with petroleum, and that soils contaminated with kerosene, diesel, or some lubricating oils estimated herein should present different characteristic values of TUCM and w...
December 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28674489/multi-finger-interaction-and-synergies-in-finger-flexion-and-extension-force-production
#16
Jaebum Park, Dayuan Xu
The aim of this study was to discover finger interaction indices during single-finger ramp tasks and multi-finger coordination during a steady state force production in two directions, flexion, and extension. Furthermore, the indices of anticipatory adjustment of elemental variables (i.e., finger forces) prior to a quick pulse force production were quantified. It is currently unknown whether the organization and anticipatory modulation of stability properties are affected by force directions and strengths of in multi-finger actions...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28664518/limnobacter-humi-sp-nov-a-thiosulfate-oxidizing-heterotrophic-bacterium-isolated-from-humus-soil-and-emended-description-of-the-genus-limnobacter-spring-et-al-2001
#17
Tuan Manh Nguyen, Jaisoo Kim
Three Gram-negative, strictly aerobic, chemolithoheterotrophic bacterial strains, designated UCM-30, UCM-33, and UCM-39(T), were isolated in South Korea. Based on their 16S rRNA gene sequences, the three isolated strains were found to be similar to Limnobacter thiooxidans CS-K2(T) (97.41-97.68%), Limnobacter litoralis KP1-19(T) (95.55-95.76%), and various genera belonging to the class Betaproteobacteria (90.34-93.34%). DNA-DNA hybridization showed 79.3-83.9% similarity between the genomic DNA of UCM-39(T), UCM-30, and UCM-33, while the sequence similarity between UCM-39(T) and L...
July 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/28643754/awareness-of-cervical-cancer-and-willingness-to-participate-in-screening-program-public-health-policy-implications
#18
Somdatta Patra, Madhu Upadhyay, Pragti Chhabra
BACKGROUND: Cervical cancer is one of the most common malignancies among women in India. There is a high mortality as patients usually present at an advanced stage because of lack of awareness and nonexistent screening programs. AIM: This study was planned to find out awareness about cervical cancer among women and their willingness to utilize screening services in an urban resettlement colony of Delhi, India. SETTINGS AND DESIGN: A community-based, cross-sectional study was carried out in a resettlement colony of North-West Delhi...
April 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28623605/cathepsin-c-aggravates-neuroinflammation-involved-in-disturbances-of-behaviour-and-neurochemistry-in-acute-and-chronic-stress-induced-murine-model-of-depression
#19
Yanli Zhang, Kai Fan, Yanna Liu, Gang Liu, Xiaohan Yang, Jianmei Ma
Major depression has been interpreted as an inflammatory disease characterized by cell-mediated immune activation, which is generally triggered by various stresses. Microglia has been thought to be the cellular link between inflammation and depression-like behavioural alterations. The expression of cathepsin C (Cat C), a lysosomal proteinase, is predominantly induced in microglia in neuroinflammation. However, little is known about the role of Cat C in pathophysiology of depression. In the present study, Cat C transgenic mice and wild type mice were subjected to an intraperitoneal injection of LPS (0...
June 16, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28609327/fluoxetine-induces-paradoxical-effects-in-c57bl6-j-mice-comparison-with-balb-c-mice
#20
Thomas Gosselin, Anne-Marie Le Guisquet, Bruno Brizard, Caroline Hommet, Frédéric Minier, Catherine Belzung
The C57BL6/J mouse is the most commonly used strain in genetic investigations and behavioural tests. However, only a few studies have used C57BL6/J mice to assess the effects of antidepressant compounds. We carried out a study to compare the behavioural effects of fluoxetine (FLX) in a model of depression in two mice strains: C57BL6/J and BALB/c. We used an 8-week unpredictable chronic mild stress (UCMS) protocol during which FLX was administered (15 mg/kg, oral) from the third week to the end of the protocol...
September 2017: Behavioural Pharmacology
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