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https://www.readbyqxmd.com/read/28810562/anti-depressant-like-effects-of-jieyu-chufan-capsules-in-a-mouse-model-of-unpredictable-chronic-mild-stress
#1
Hui Zhao, Bingyu Liang, Linjie Yu, Yun Xu
Jieyu chufan (JYCF) is a well-known Chinese traditional medicine used for depression; however, the molecular mechanism underlying its anti-depressant action has remained elusive. In the present study, the anti-depressant effects of JYCF and the potential mechanisms were investigated in a mouse model. Five groups of 12 C57BL/6 mice each were used in the study, including a normal control group (NC group), a model control group (MC group) and three groups, which received different doses of JYCF (1.25, 2.5 and 5 g/kg) orally for 21 days (JYCF groups)...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28809147/flavobacterium-flaviflagrans-sp-nov-a-bacterium-of-the-family-flavobacteriaceae-isolated-from-forest-soil
#2
Ram Hari Dahal, Dhiraj Kumar Chaudhary, Jaisoo Kim
Two strains of bacteria designated CB-3T and CB-31 were isolated from Kyonggi University forest soil. Cells were aerobic, Gram-stain-negative, oxidase-positive, non-motile, non-spore-forming, rod-shaped and yellow-pigmented. They were able to grow at 15-42 °C, pH 5.5-9.5 and with 0-1.5 % (w/v) NaCl concentration. Flexirubin-type pigments were absent. Phylogenetic analysis based on 16S rRNA gene sequences revealed that strains CB-3T and CB-31 formed a lineage within the family Flavobacteriaceae of the phylum Bacteroidetes that was distinct from various species of the genus Flavobacterium, including Flavobacterium humicola UCM-46T (99...
August 15, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28803118/complex-interactions-between-the-subject-factors-of-biological-sex-and-prior-histories-of-binge-drinking-and-unpredictable-stress-influence-behavioral-sensitivity-to-alcohol-and-alcohol-intake
#3
Sema G Quadir, Eugenie Guzelian, Mason A Palmer, Douglas L Martin, Jennifer Kim, Karen K Szumlinski
Alcohol use disorders, affective disorders and their comorbidity are sexually dimorphic in humans. However, it is difficult to disentangle the interactions between subject factors influencing alcohol sensitivity in studies of humans. Herein, we combined murine models of unpredictable, chronic, mild stress (UCMS) and voluntary binge-drinking to examine for sex differences in the interactions between prior histories of excessive ethanol-drinking and stress upon ethanol-induced changes in motor behavior and subsequent drinking...
August 9, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28782590/may-the-use-of-different-background-strains-strain-the-stress-related-phenotype-of-gr-mice
#4
Miriam A Vogt, Natascha Pfeiffer, Anne Marie Le Guisquet, Christiane Brandwein, Bruno Brizard, Peter Gass, Catherine Belzung, Sabine Chourbaji
Genetically altered mice are available on different background strains. While respective backcrosses are often performed for pragmatic reasons, e.g. references, comparability, or existing protocols, the interaction between the mutations per se and the background strain often remains a neglected factor. The heterozygous mutation of the glucocorticoid receptor gene (GR) represents a well-examined model for depressive-like behavior in mice. To address the question in how far a robust depressive-like phenotype on a distinct background strain may allow a generalized conclusion, we analyzed respective phenotypes in two commonly used inbred strains: i...
August 3, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28712771/characterization-and-ecological-risk-of-polycyclic-aromatic-hydrocarbons-pahs-and-n-alkanes-in-sediments-of-shadegan-international-wetland-the-persian-gulf
#5
Akram Bemanikharanagh, Alireza Riyahi Bakhtiari, Jahangard Mohammadi, Ruhollah Taghizadeh-Mehrjardi
The distribution and sources of PAHs and n-alkanes were determined in the surface sediments from 202 locations in Shadegan international wetland with 537,700ha. The concentrations of total n-alkanes and PAHs ranged from 395.3 to 14933.46μgg(-1)dw and 593.74 to 53393.86ngg(-1)dw, respectively. Compared with other worldwide surveys, the concentration and contamination of sedimentary hydrocarbons were classified very high. A common petrogenic hydrocarbon source was strongly suggested in all sites by n-alkanes' profile with a Cmax at n-C20, Pr/Ph and CPI ratios<1 in all sites, and high percentage of UCM...
July 13, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28711771/toxicity-of-organic-compounds-from-unresolved-complex-mixtures-ucms-to-primary-fish-hepatocytes
#6
Karina Petersen, Maria T Hultman, Steven J Rowland, Knut Erik Tollefsen
Many environmental matrices contaminated with organic pollutants derived from crude oil or degraded petroleum contain mixtures so complex that they are typically unresolved by conventional analytical techniques such as gas chromatography. The resulting chromatographic features have become known as 'humps' or unresolved complex mixtures (UCMs). These UCMs often dominate the organic contaminants of polluted environmental samples: for example, in oil sands produced water up to 150mgL(-1) of 'naphthenic acids' appear as UCMs when examined by gas chromatography as the esters...
September 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28705628/characteristics-and-sources-of-anthropogenic-and-biogenic-hydrocarbons-in-sediments-from-the-coast-of-qatar
#7
Ahmed I Rushdi, Ismail Al-Shaikh, Aarif H El-Mubarak, Hajer A J A Alnaimi, Noora Al-Shamary, Hassan M Hassan, Mazen Abou Assali
Surface sediment samples from the coastal zone of Qatar were collected and analyzed to determine the characteristics, and sources of anthropogenic and biogenic hydrocarbons. The main compounds in these surface sediments included n-alkanes, methyl n-alkanoates, diterpenoids, hopanes, steranes, phthalate esters, polycyclic aromatic hydrocarbons (PAHs) and unresolved complex mixture (UCM). Their total concentrations ranged from 18.7±3.7-81.1±7.5ng/g (3.7±0.6-10.4±4.8%) for n-alkanes, 8.3±2.3-51±3.4ng/g (3...
July 10, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28686894/identification-of-weathered-multiple-petroleum-products-in-contaminated-soils-by-characterizing-unresolved-complex-mixture-hump-in-gas-chromatograph-data
#8
Soo-Kyung Jeon, Dongwook Kwon, Seunghak Lee
A new method for identifying the petroleum products in contaminated soils is presented, which characterizes the unresolved complex mixture (UCM) hump in the baseline of gas chromatograph (GC) data. The UCM hump identified in soil data was fitted to the Gaussian function, and characterized according to the time for the maximum point (TUCM) and the width of the hump (w). Experimental results showed that a UCM hump should be clearly observed in soils when contaminated with petroleum, and that soils contaminated with kerosene, diesel, or some lubricating oils estimated herein should present different characteristic values of TUCM and w...
July 4, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28674489/multi-finger-interaction-and-synergies-in-finger-flexion-and-extension-force-production
#9
Jaebum Park, Dayuan Xu
The aim of this study was to discover finger interaction indices during single-finger ramp tasks and multi-finger coordination during a steady state force production in two directions, flexion, and extension. Furthermore, the indices of anticipatory adjustment of elemental variables (i.e., finger forces) prior to a quick pulse force production were quantified. It is currently unknown whether the organization and anticipatory modulation of stability properties are affected by force directions and strengths of in multi-finger actions...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28664518/limnobacter-humi-sp-nov-a-thiosulfate-oxidizing-heterotrophic-bacterium-isolated-from-humus-soil-and-emended-description-of-the-genus-limnobacter-spring-et-al-2001
#10
Tuan Manh Nguyen, Jaisoo Kim
Three Gram-negative, strictly aerobic, chemolithoheterotrophic bacterial strains, designated UCM-30, UCM-33, and UCM-39(T), were isolated in South Korea. Based on their 16S rRNA gene sequences, the three isolated strains were found to be similar to Limnobacter thiooxidans CS-K2(T) (97.41-97.68%), Limnobacter litoralis KP1-19(T) (95.55-95.76%), and various genera belonging to the class Betaproteobacteria (90.34-93.34%). DNA-DNA hybridization showed 79.3-83.9% similarity between the genomic DNA of UCM-39(T), UCM-30, and UCM-33, while the sequence similarity between UCM-39(T) and L...
July 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/28643754/awareness-of-cervical-cancer-and-willingness-to-participate-in-screening-program-public-health-policy-implications
#11
Somdatta Patra, Madhu Upadhyay, Pragti Chhabra
BACKGROUND: Cervical cancer is one of the most common malignancies among women in India. There is a high mortality as patients usually present at an advanced stage because of lack of awareness and nonexistent screening programs. AIM: This study was planned to find out awareness about cervical cancer among women and their willingness to utilize screening services in an urban resettlement colony of Delhi, India. SETTINGS AND DESIGN: A community-based, cross-sectional study was carried out in a resettlement colony of North-West Delhi...
April 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28623605/cathepsin-c-aggravates-neuroinflammation-involved-in-disturbances-of-behaviour-and-neurochemistry-in-acute-and-chronic-stress-induced-murine-model-of-depression
#12
Yanli Zhang, Kai Fan, Yanna Liu, Gang Liu, Xiaohan Yang, Jianmei Ma
Major depression has been interpreted as an inflammatory disease characterized by cell-mediated immune activation, which is generally triggered by various stresses. Microglia has been thought to be the cellular link between inflammation and depression-like behavioural alterations. The expression of cathepsin C (Cat C), a lysosomal proteinase, is predominantly induced in microglia in neuroinflammation. However, little is known about the role of Cat C in pathophysiology of depression. In the present study, Cat C transgenic mice and wild type mice were subjected to an intraperitoneal injection of LPS (0...
June 16, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28609327/fluoxetine-induces-paradoxical-effects-in-c57bl6-j-mice-comparison-with-balb-c-mice
#13
Thomas Gosselin, Anne-Marie Le Guisquet, Bruno Brizard, Caroline Hommet, Frédéric Minier, Catherine Belzung
The C57BL6/J mouse is the most commonly used strain in genetic investigations and behavioural tests. However, only a few studies have used C57BL6/J mice to assess the effects of antidepressant compounds. We carried out a study to compare the behavioural effects of fluoxetine (FLX) in a model of depression in two mice strains: C57BL6/J and BALB/c. We used an 8-week unpredictable chronic mild stress (UCMS) protocol during which FLX was administered (15 mg/kg, oral) from the third week to the end of the protocol...
September 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/28605720/hydrocarbon-composition-and-concentrations-in-the-gulf-of-mexico-sediments-in-the-3-years-following-the-macondo-well-blowout
#14
Lydia Babcock-Adams, Jeffrey P Chanton, Samantha B Joye, Patricia M Medeiros
In April of 2010, the Macondo well blowout in the northern Gulf of Mexico resulted in an unprecedented release of oil into the water column at a depth of approximately 1500 m. A time series of surface and subsurface sediment samples were collected to the northwest of the well from 2010 to 2013 for molecular biomarker and bulk carbon isotopic analyses. While no clear trend was observed in subsurface sediments, surface sediments (0-3 cm) showed a clear pattern with total concentrations of n-alkanes, unresolved complex mixture (UCM), and petroleum biomarkers (terpanes, hopanes, steranes) increasing from May to September 2010, peaking in late November 2010, and strongly decreasing in the subsequent years...
June 9, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28599837/measurement-of-testosterone-and-cortisol-metabolites-and-luteinising-hormone-in-captive-southern-hairy-nosed-wombat-lasiorhinus-latifrons-urine
#15
Z Du, T Keeley, T Janssen, V Nicolson, S D Johnston
This study reports the validation and use of enzyme immunoassays (EIA) to measure changes in plasma and urinary luteinizing hormone, testosterone metabolites (UTM) and cortisol metabolites (UCM) in captive southern hairy-nosed wombats (Lasiorhinus latifrons). GnRH agonist and ACTH agonist challenges were conducted to validate urinary testosterone (male wombat only) and cortisol (male and female wombats) EIAs. Following intra-muscular injection of 8-12μg buserelin (n=4 males), there was a significant increase in both plasma (P<0...
June 17, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28594374/higher-anti-liver-fibrosis-effect-of-cordyceps-militaris-fermented-product-cultured-with-deep-ocean-water-via-inhibiting-proinflammatory-factors-and-fibrosis-related-factors-expressions
#16
Yu-Ping Hung, Chun-Lin Lee
Deep ocean water (DOW) has been shown to enhance the functional components of fungi, resulting in increased health benefits. Therefore, using DOW for culturing fungi can enhance the cordycepin and adenosine of Cordyceps militaris (CM) and its protective effects on the liver. In this study, the antiliver fibrosis effects and mechanisms of ultrapure water-cultured CM (UCM), DOW-cultured CM (DCM), synthetic water-cultured CM, DOW, cordycepin, and adenosine were compared in the liver fibrosis mice induced by intraperitoneal injections of thioacetamide (TAA)...
June 8, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28572058/behavioral-inflammatory-and-neurochemical-disturbances-in-lps-and-ucms-induced-mouse-models-of-depression
#17
Xinnan Zhao, Fengrui Cao, Qing Liu, Xinsheng Li, Guoyang Xu, Gang Liu, Yanli Zhang, Xiaohan Yang, Shansong Yi, Fenghua Xu, Kai Fan, Jianmei Ma
The immuno-inflammatory activation triggered by various stresses play an important role in pathophysiology of depression. The immune responses display differential pathological characters in different stresses. However, comparative data and analysis on behavioural, inflammatory and neurochemical changes in different stress-induced depression is limited. To imitate different stressful situations, in this study, mice were subjected to a single injection of LPS (0.5mg/kg, i.p.) and UCMS (4 week period), respectively...
May 29, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28552253/occurrence-source-and-ecological-assessment-of-baseline-hydrocarbons-in-the-intertidal-marine-sediments-along-the-shoreline-of-douglas-channel-to-hecate-strait-in-british-columbia
#18
Zeyu Yang, Bruce P Hollebone, Sonia Laforest, Patrick Lambert, Carl E Brown, Chun Yang, Keval Shah, Mike Landriault, Michael Goldthorp
The occurrence, source and ecological assessment of baseline hydrocarbons in the intertidal zone along the northern British shoreline were evaluated based on analyzing total petroleum hydrocarbons (TPH), n-alkanes, petroleum related biomarkers such as terpanes and steranes, and polycyclic aromatic hydrocarbons (PAHs) including non-alkylated and alkylated homologues (APAHs). The TPH levels, n-alkanes, petroleum biomarkers and PAHs in all the sampling sites, except for Masset Harbor/York Point at Gil Island were low, without obvious unresolved complex mixture (UCM) and petroleum contamination input...
May 25, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28490697/-effect-of-left-ventricular-hypertrophy-and-deformation-on-cardiac-function-in-patients-with-uremia-cardiomyopathy-by-using-quantitative-speckle-tracking-technology
#19
Yi Zheng, Xiaohong Yang, Qiping Zhou, Yaoyao Huang, Fan Zhang, Liangyu Wang
To evaluate the effect of left ventricular hypertrophy and deformation on cardiac function in patients with uremic cardiomyopathy (UCM) by using the technology of two dimensional speckle tracking imaging (2D-STI).
 Methods: A total of 67 UCM patients were randomly divided into the normal cardiac function group (subgroup A, 32 cases) and the abnormal cardiac function group (subgroup B, 35 cases) according to the New York Heart Association points (NYHA-P). A total of 30 healthy subjetcs served as the control group...
April 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28486779/expansion-strategies-for-human-mesenchymal-stromal-cells-culture-under-xeno-free-conditions
#20
Patrícia Aparecida Tozetti, Samia Rigotto Caruso, Amanda Mizukami, Taisa Risque Fernandes, Fernanda Borges da Silva, Fabiola Traina, Dimas Tadeu Covas, Maristela Delgado Orellana, Kamilla Swiech
Choosing the culture system and culture medium used to produce cells are key steps towards a safe, scalable and cost-effective expansion bioprocess for cell therapy purposes. The use of AB human serum (AB HS) as an alternative xeno-free supplement for mesenchymal stromal cells (MSC) cultivation has increasingly gained relevance due to safety and efficiency aspects. Here we have evaluated different scalable culture systems to produce a meaningful number of umbilical cord matrix-derived MSC (UCM MSC) using AB HS for culture medium supplementation during expansion and cryopreservation to enable a xeno-free bioprocess...
May 9, 2017: Biotechnology Progress
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