O Sheehy, S Eltonsy, S Hawken, M Walker, P Kaul, B Winquist, O Barrett, A Savu, R Dragan, M Pugliese, S Bernatsky, J Gorgui, A Bérard
Health Canada (HC) has, since 2013, issued safety alerts restricting the use of codeine-containing drugs among breastfeeding women and children/adolescents under 18 years of age. These products are linked to breathing problems among ultra-rapid CYP2D6 metabolizers and early use of opioid can lead to future opioid misuse. Using a multi-province population-based cohort study, we estimate the impact of federal safety alerts on annual rates of codeine use in the Canadian pediatric population. We analyzed data from 8,156,948 children/adolescents in five Canadian provinces between 1996 and 2021, using a common protocol...
March 4, 2024: Scientific Reports