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https://www.readbyqxmd.com/read/28544992/pharmacokinetics-pharmacodynamics-and-tolerability-of-usl261-midazolam-nasal-spray-randomized-study-in-healthy-geriatric-and-non-geriatric-adults
#1
Alexander K Berg, Michael J Myrvik, Peter J Van Ess
AIM: Characterize pharmacokinetics, pharmacodynamics, and safety/tolerability of USL261 in geriatric adults to inform its potential for treating bouts of increased seizure activity. METHODS: Phase 1, randomized, double-blind, 2-way crossover study in healthy geriatric (≥65years; n=18) and non-geriatric (18-40years; n=12) adults evaluated single USL261 doses (2.5 and 5.0mg) administered intranasally. Pharmacokinetic parameters were estimated for midazolam and 1-hydroxymidazolam (active metabolite), including area under the plasma concentration-time curve (AUC), maximum plasma concentration (Cmax), time to Cmax (Tmax), and half-life (t1/2)...
May 22, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28543427/conservation-of-resources-theory-in-nurse-burnout-and-patient-safety
#2
Aoyjai Prapanjaroensin, Patricia A Patrician, David E Vance
AIMS: To examine how the Conservation of Resources theory explains burnout in the nursing profession. BACKGROUND: Burnout, which is an accumulation of work-related mental stress in people-oriented occupations, has been an issue of concern for decades for healthcare workers, especially nurses. Yet, few studies have examined a unified theory that explains the etiology, progression and consequences of nurse burnout. DESIGN: This discussion article integrates current knowledge on nurse burnout using Conservation of Resources theory, which focuses on four resources (i...
May 24, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28540764/japan-flavour-and-fragrance-materials-association-s-safety-assessment-of-food-flavouring-substances-uniquely-used-in-japan-that-belong-to-the-class-of-aliphatic-primary-alcohols-aldehydes-carboxylic-acids-acetals-and-esters-containing-additional-oxygenated
#3
Kenji Saito, Yasuko Hasegawa-Baba, Fumiko Sekiya, Shim-Mo Hayashi, Yoshiharu Mirokuji, Hiroyuki Okamura, Shinpei Maruyama, Atsushi Ono, Madoka Nakajima, Masakuni Degawa, Shogo Ozawa, Makoto Shibutani, Tamio Maitani
We performed a safety evaluation using the procedure devised by the Joint FAO/WHO Expert Committee on Food Additives of the following four flavouring substances that belong to the class of 'aliphatic primary alcohols, aldehydes, carboxylic acids, acetals, and esters containing additional oxygenated functional groups' and are uniquely used in Japan: butyl butyrylacetate, ethyl 2-hydroxy-4-methylpentanoate, 3-hydroxyhexanoic acid and methyl hydroxyacetate. Although no genotoxicity study data were found in the published literature, none of the four substances had chemical structural alerts predicting genotoxicity...
May 25, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28540756/nonadjunctive-use-of-continuous-glucose-monitors-for-insulin-dosing
#4
Alan R Shapiro
With the increasing accuracy of continuous glucose monitors (CGM) have come calls for the Food and Drug Administration (FDA) to label these devices as safe for nonadjunctive dosing of insulin. However, there is evidence that these devices are subject to sporadic, unpredictable, large errors. A text analysis of reports to the FDA MAUDE database since 2015 reveals over 25 000 complaints of CGM sensor inaccuracy, with instances directly leading to serious outcomes. These new data were not considered at a recent FDA Advisory Panel meeting that voted to approve Dexcom G5 relabeling for nonadjunctive use...
March 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28527100/parents-expectations-of-high-schools-in-firearm-violence-prevention
#5
Erica Payton, Jagdish Khubchandani, Amy Thompson, James H Price
Firearm violence remains a significant problem in the US (with 2787 adolescents killed in 2015). However, the research on school firearm violence prevention practices and policies is scant. Parents are major stakeholders in relation to firearm violence by youths and school safety in general. The purpose of this study was to examine what parents thought schools should be doing to reduce the risk of firearm violence in schools. A valid and reliable questionnaire was mailed to a national random sample of 600 parents who had at least one child enrolled in a public secondary school (response rate = 47%)...
May 19, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28520711/inhalational-chlorine-injuries-at-public-aquatic-venues-california-2008-2015
#6
Jason A Wilken, Michele DiMaggio, Matthew Kaufmann, Kevin O'Connor, Svetlana Smorodinsky, Christina Armatas, Tracy Barreau, Richard Kreutzer, Lino Ancheta
In June 2015, personnel from California's Contra Costa Health Services Environmental Health and Hazardous Materials (hazmat) divisions were alerted to a possible chemical release at a swimming pool in an outdoor municipal water park. Approximately 50 bathers were in the pool when symptoms began; 34 (68%) experienced vomiting, coughing, or eye irritation. Among these persons, 17 (50%) were treated at the scene by Contra Costa's Emergency Medical Services (EMS) and released, and 17 (50%) were transported to local emergency departments; five patients also were evaluated later at an emergency department or by a primary medical provider...
May 19, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28510495/fatigue-in-younger-and-older-drivers-effectiveness-of-an-alertness-maintaining-task
#7
Woojin Song, Fu L Woon, Alice Doong, Carol Persad, Louis Tijerina, Pooja Pandit, Carol Cline, Bruno Giordani
OBJECTIVE: The aim of this study was to examine the effects of an alertness maintaining task (AMT) in older, fatigued drivers. BACKGROUND: Fatigue during driving increases crash risk, and previous research suggests that alertness and driving in younger adults may be improved using a secondary AMT during boring, fatigue-eliciting drives. However, the potential impact of an AMT on driving has not been investigated in older drivers whose ability to complete dual tasks has been shown to decline and therefore may be negatively affected with an AMT in driving...
May 1, 2017: Human Factors
https://www.readbyqxmd.com/read/28506977/development-of-a-medication-review-service-for-patients-with-enteral-tubes-in-a-community-teaching-hospital
#8
Tracey Li, Alison Eisenhart, Jennifer Costello
PURPOSE: The results of a study to develop a hospital-wide medication review service for patients with enteral tubes to improve patient safety are presented. SUMMARY: Inappropriate enteral administration of medications can result in occluded tubes, altered clinical response, and an increase in adverse effects. At Saint Barnabas Medical Center, a 600-bed community teaching hospital located in Livingston, New Jersey, a medication review service for patients with an enteral tube was developed...
June 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28503093/alarms-about-structural-alerts
#9
Vinicius Alves, Eugene Muratov, Stephen Capuzzi, Regina Politi, Yen Low, Rodolpho Braga, Alexey V Zakharov, Alexander Sedykh, Elena Mokshyna, Sherif Farag, Carolina Andrade, Victor Kuz'min, Denis Fourches, Alexander Tropsha
Structural alerts are widely accepted in chemical toxicology and regulatory decision support as a simple and transparent means to flag potential chemical hazards or group compounds into categories for read-across. However, there has been a growing concern that alerts disproportionally flag too many chemicals as toxic, which questions their reliability as toxicity markers. Conversely, the rigorously developed and properly validated statistical QSAR models can accurately and reliably predict the toxicity of a chemical; however, their use in regulatory toxicology has been hampered by the lack of transparency and interpretability...
August 21, 2016: Green Chemistry: An International Journal and Green Chemistry Resource: GC
https://www.readbyqxmd.com/read/28495338/adoption-of-medication-alert-systems-in-hospital-outpatient-departments-in-taiwan
#10
Yu-Chun Kuo, Shou-Hsia Cheng
OBJECTIVE: The adoption of medication alert systems in the health care sector varies among regions. In Taiwan, the health authority introduced policies in 2005 to encourage the adoption of medication alert systems in hospitals. This study aimed to understand the adoption of medication alert systems in the outpatient departments of hospitals in Taiwan using a nationwide survey. METHODS: A questionnaire was developed and mailed to 380 accredited general hospitals in Taiwan in 2013...
June 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/28488994/establishing-and-maintaining-the-national-vaccination-register-in-finland
#11
Ulrike Baum, Jonas Sundman, Susanna Jääskeläinen, Hanna Nohynek, Taneli Puumalainen, Jukka Jokinen
Computerised, population-based vaccination registers are valuable tools for assessing the vaccine uptake and impact in populations. However, reliable impact assessment is only possible if the data quality can be reviewed and monitored continuously. This report describes the establishment and maintenance of the National Vaccination Register (NVR) in Finland. Currently, the NVR covers nationwide records of vaccinations given within the frame of the National Vaccination Programme since 2009. All vaccinations registered in the NVR contain a record of the personal identity code, the administered vaccine, and the date of vaccination...
April 27, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28486375/domperidone-for-lactation-what-health-care-providers-need-to-know
#12
Catherine A Sewell, Christina Y Chang, Miriam M Chehab, Christine P Nguyen
This commentary serves to raise health care provider awareness about the regulatory status and available evidence regarding domperidone for insufficient lactation. Breastfeeding provides significant health benefits for mothers and infants, and insufficient milk production remains the most common reason for early weaning. Domperidone, a dopamine receptor antagonist that may increase milk production, is not approved for any human use in the United States. It is approved in some countries for certain gastrointestinal disorders, but is not approved in any country for lactation enhancement...
June 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28473306/using-a-medical-intranet-of-things-system-to-prevent-bed-falls-in-an-acute-care-hospital-a-pilot-study
#13
Henri U Balaguera, Diana Wise, Chun Yin Ng, Han-Wen Tso, Wan-Lin Chiang, Aimee M Hutchinson, Tracy Galvin, Lee Hilborne, Cathy Hoffman, Chi-Cheng Huang, C Jason Wang
BACKGROUND: Hospitalized patients in the United States experience falls at a rate of 2.6 to 17.1 per 1000 patient-days, with the majority occurring when a patient is moving to, from, and around the bed. Each fall with injury costs an average of US $14,000. OBJECTIVE: The aim was to conduct a technology evaluation, including feasibility, usability, and user experience, of a medical sensor-based Intranet of things (IoT) system in facilitating nursing response to bed exits in an acute care hospital...
May 4, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28467334/quality-control-on-radiochemical-purity-in-technetium-99m-radiopharmaceuticals-labelling-three-years-of-experience-on-2280-procedures
#14
Claudio Maioli, Giovanni Luciniani, Aldo Strinchini, Luca Tagliabue, Angelo Del Sole
OBJECTIVE: the purpose of this study was to offer an example of evaluations of the ISO9001 certified internal quality assurance (QA) system of 99mTc-radiopharmaceutical preparations and quality control in vivo use, using industrial kits and generators in order to identify possible sources of errors in the procedures labeling and quality control procedures. METHODS: The study was performed at a single institution over a period of three years (July 1st, 2011 - July 1st, 2014), and included a total of 2280 radiopharmaceutical preparations prepared by four different technologists...
April 28, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/28465369/statins-time-to-rationalise-lfts
#15
(no author information available yet)
Statins: time to rationalise LFTs? ● Limited evidence for low-cost devices to improve adherence ● MHRA safety alert: hyoscine butylbromide (Buscopan) injection ● Faecal microbiota transplantation for ulcerative colitis ● Magnesium for nocturnal leg cramps ● NSAIDs and risk of out-of-hospital cardiac arrest ● Off-label antidepressant prescribing.
May 2, 2017: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/28465364/mhra-safety-alert-hyoscine-butylbromide-buscopan-injection
#16
(no author information available yet)
No abstract text is available yet for this article.
May 2, 2017: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/28465223/the-maximum-tolerated-dose-of-walking-for-community-dwelling-people-recovering-from-hip-fracture-a-dose-response-trial
#17
Casey Peiris, Nora Shields, Michael Kingsley, Jack Yeung, Raphael Hau, Nicholas Taylor
OBJECTIVE: To determine how much moderate-intensity physical activity, in the form of walking, could be prescribed for people living in the community after hip fracture in terms of safety, tolerability and feasibility. DESIGN: Phase I dose-response design. SETTING: Participants were recruited from two public community rehabilitation centres in Melbourne, Australia. PARTICIPANTS: Community-dwelling adults (n=21, 16 women, mean age ± SD, 75 ± 9 years) who were cognitively alert, attending community rehabilitation after a hip fracture (mean ± SD days post fracture, 110 ± 47 days), able to walk with or without a gait aid and for whom it was safe to participate in physical activity...
April 29, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28459733/a-phase-1-single-center-double-blind-placebo-controlled-study-in-healthy-subjects-to-assess-the-safety-tolerability-clinical-effects-and-pharmacokinetics-pharmacodynamics-of-intravenous-cyclopropyl-methoxycarbonylmetomidate-abp-700-after-a-single-ascending
#18
Michel M R F Struys, Beatrijs I Valk, Douglas J Eleveld, Anthony R Absalom, Peter Meyer, Sascha Meier, Izaak den Daas, Thomas Chou, Kai van Amsterdam, Jason A Campagna, Steven P Sweeney
BACKGROUND: Cyclopropyl-methoxycarbonylmetomidate (ABP-700) is a new "soft" etomidate analog. The primary objectives of this first-in-human study were to describe the safety and efficacy of ABP-700 and to determine its maximum tolerated dose. Secondary objectives were to characterize the pharmacokinetics of ABP-700 and its primary metabolite (cyclopropyl-methoxycarbonyl acid), to assess the clinical effects of ABP-700, and to investigate the dose-response and pharmacokinetic/pharmacodynamic relationships...
May 1, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28454872/effects-of-an-integrated-collision-warning-system-on-teenage-driver-behavior
#19
Jessica S Jermakian, Shan Bao, Mary Lynn Buonarosa, James R Sayer, Charles M Farmer
INTRODUCTION: Crash warning systems have been shown to provide safety benefits, but no studies have examined how teenagers respond. This study sought to find out whether young, inexperienced drivers change behavior in response to warnings. METHODS: Forty 16-17 year-olds drove an instrumented vehicle equipped with a system that warned for lane departures and potential rear-end and lane change/merge crashes. Participants were randomly assigned to experimental or control groups, and their driving was monitored for 14weeks during 2011-12...
June 2017: Journal of Safety Research
https://www.readbyqxmd.com/read/28454858/the-relationship-between-cell-phone-use-and-management-of-driver-fatigue-it-s-complicated
#20
Dyani Juanita Saxby, Gerald Matthews, Catherine Neubauer
INTRODUCTION: Voice communication may enhance performance during monotonous, potentially fatiguing driving conditions (Atchley & Chan, 2011); however, it is unclear whether safety benefits of conversation are outweighed by costs. The present study tested whether personalized conversations intended to simulate hands-free cell phone conversation may counter objective and subjective fatigue effects elicited by vehicle automation. METHOD: A passive fatigue state (Desmond & Hancock, 2001), characterized by disengagement from the task, was induced using full vehicle automation prior to drivers resuming full control over the driving simulator...
June 2017: Journal of Safety Research
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