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https://www.readbyqxmd.com/read/29118505/descemet-s-membrane-macroperforation-during-interface-irrigation-in-big-bubble-deep-anterior-lamellar-keratoplasty
#1
Mohammed Ziaei, Susan E Ormonde
This report describes the macroperforation of descemet's membrane (DM) during irrigation of the interface following successful removal of stromal tissue in big bubble (BB) deep anterior lamellar keratoplasty (DALK). A 42-year-old woman with keratoconus underwent a BB DALK procedure. After successful formation of Type 2 bubble and removal of stromal tissue, interface irrigation was performed to remove residual viscoelastic. This led to a macroperforation of DM, and the case was converted to penetrating keratoplasty...
September 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/29115760/efficacy-and-safety-of-cannabis-for-treating-children-with-refractory-epilepsy
#2
Michelle Neale
The aim of this literature review was to examine the evidence base for the safety and efficacy of cannabis in treating children with refractory epilepsy. Clinical and medical databases were searched and four articles were included in the final analysis, which included retrospective reviews and open-label trials with a total sample size of 424. One clinical trial included administration of cannabidiol, the non-psychoactive compound of cannabis, while the other three articles stated that the compound administered to participants contained tetrahydrocannabidiol, the psychoactive constituent of cannabis...
September 11, 2017: Nursing Children and Young People
https://www.readbyqxmd.com/read/29112077/technologic-distractions-part-2-a-summary-of-approaches-to-manage-clinical-alarms-with-intent-to-reduce-alarm-fatigue
#3
Bradford D Winters, Maria M Cvach, Christopher P Bonafide, Xiao Hu, Avinash Konkani, Michael F O'Connor, Jeffrey M Rothschild, Nicholas M Selby, Michele M Pelter, Barbara McLean, Sandra L Kane-Gill
OBJECTIVE: Alarm fatigue is a widely recognized safety and quality problem where exposure to high rates of clinical alarms results in desensitization leading to dismissal of or slowed response to alarms. Nonactionable alarms are thought to be especially problematic. Despite these concerns, the number of clinical alarm signals has been increasing as an everincreasing number of medical technologies are added to the clinical care environment. DATA SOURCES: PubMed, SCOPUS, Embase, and CINAHL...
November 3, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29109935/striking-balance-between-expedited-review-and-expecting-efficacious-anticancer-drug-and-biologics-an-ongoing-challenge
#4
Krishnan Vengadaragava Chary, Anita Ramesh
Objective: The objective of this study is to assess the postmarketing status: Efficacy and safety drugs and biologics related with cancer approved under expedited review. Methods: This observational, analytical study was carried between January and April 2016 by the Department of Pharmacology and Medical Oncology, Saveetha Medical College. Drugs approved under expedited review, fast-track status and its association with anti-cancer effects, postmarketing efficacy and safety, propensity to induce the second tumor was noted...
October 2017: Perspectives in Clinical Research
https://www.readbyqxmd.com/read/29103654/equilibrium-sampling-informs-tissue-residue-and-sediment-remediation-for-pyrethroid-insecticides-in-mariculture-a-laboratory-demonstration
#5
Juan-Ying Li, Wenxuan Shi, Zhenhua Li, Yiqin Chen, Liu Shao, Ling Jin
Mariculture product safety in relation to sediment quality has attracted increasing attention because of the accumulation of potentially hazardous chemicals, including pyrethroid insecticides, in sediment. Passive sampling has been widely used to assess the bioavailability of sediment-associated hydrophobic organic contaminants and predict their body residue in benthic organisms. Therefore, in this study, we introduced polydimethylsiloxane (PDMS) polymer as a biomimetic "chemometer" for freely-dissolved concentrations (Cfree) to assess the efficacy of different carbon sorbents in reducing the bioavailability of pyrethroids in the process of sediment remediation...
November 2, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29096163/safety-at-the-william-quarrier-scottish-epilepsy-centre
#6
James Anderson, Victoria Grant, Mariam Elgammal, Alison Campbell, Julia Hampshire, Stig Hansen, Aline J C Russell
PURPOSE: We examined the yield from EMFIT bed alarms and staff response time to generalised seizure in a medium term residential assessment unit for epilepsy. METHODS: The Scottish Epilpesy Centre (SEC) has a Video Observation System (VOS) that provides continuous recording of all patient spaces (external and internal) and allows retention of clinically relevant events. A retrospective audit of daily EMFIT test records, nursing seizure record sheets (seizure type and EMFIT alert status), clinical incident reporting systems and the VOS database of retained clinical events was conducted for an 9 month period from April 1st 2016 till December 31st 2016...
October 16, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29093040/digital-media-and-sleep-in-childhood-and-adolescence
#7
REVIEW
Monique K LeBourgeois, Lauren Hale, Anne-Marie Chang, Lameese D Akacem, Hawley E Montgomery-Downs, Orfeu M Buxton
Given the pervasive use of screen-based media and the high prevalence of insufficient sleep among American youth and teenagers, this brief report summarizes the literature on electronic media and sleep and provides research recommendations. Recent systematic reviews of the literature reveal that the vast majority of studies find an adverse association between screen-based media consumption and sleep health, primarily via delayed bedtimes and reduced total sleep duration. The underlying mechanisms of these associations likely include the following: (1) time displacement (ie, time spent on screens replaces time spent sleeping and other activities); (2) psychological stimulation based on media content; and (3) the effects of light emitted from devices on circadian timing, sleep physiology, and alertness...
November 2017: Pediatrics
https://www.readbyqxmd.com/read/29060815/prediction-of-fatigue-related-driver-performance-from-eeg-data-by-deep-riemannian-model
#8
Mehdi Hajinoroozi, Jianqiu Zhang, Yufei Huang
Prediction of the drivers' drowsy and alert states is important for safety purposes. The prediction of drivers' drowsy and alert states from electroencephalography (EEG) using shallow and deep Riemannian methods is presented. For shallow Riemannian methods, the minimum distance to Riemannian mean (mdm) and Log-Euclidian metric are investigated, where it is shown that Log-Euclidian metric outperforms the mdm algorithm. In addition the SPDNet, a deep Riemannian model, that takes the EEG covariance matrix as the input is investigated...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29060733/development-of-a-thermal-associated-pain-index-score-using-infrared-thermography-for-objective-pain-assessment
#9
M Czaplik, N Hochhausen, H Dohmeier, C Barbosa Pereira, R Rossaint
Without any doubt, research in biomedical engineering and anesthesiology achieved diverse ground-breaking successes for the sake of patient safety and for optimization of medical treatment in the last decades. Particularly anesthesia has become increasingly comfortable and safer due to new monitoring devices and further techniques. However, assessment of pain still relies on self-reporting of the patient using a Numeric Rating Scale ranging from 0 to 10. Obviously, this method suffers from severe restraints when unconscious, anesthetized or uncooperative subjects or children are involved as patients...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29058969/public-health-and-the-pope-s-visit-to-philadelphia-2015
#10
James W Buehler, Jessica Caum, Steven J Alles
Pope Francis visited Philadelphia for 2 days during September 2015. Preparedness functions managed by the Philadelphia Department of Public Health (PDPH) were similar to those of other mass gatherings but also required accommodation of special security arrangements and the location of public events in central areas of the city. Public health planning involved collaborations with multiple city, state, and federal agencies and neighboring jurisdictions. PDPH preparations encompassed incident command procedures, contingency planning, disease surveillance and prevention, food safety, vector control, BioWatch air sampling, volunteer management for first-aid services, and continuity of operations...
September 2017: Health Security
https://www.readbyqxmd.com/read/29049076/fatigue-risk-management-the-impact-of-anesthesiology-residents-work-schedules-on-job-performance-and-a-review-of-potential-countermeasures
#11
Lily R Wong, Erin Flynn-Evans, Keith J Ruskin
Long duty periods and overnight call shifts impair physicians' performance on measures of vigilance, psychomotor functioning, alertness, and mood. Anesthesiology residents typically work between 64 and 70 hours per week and are often required to work 24 hours or overnight shifts, sometimes taking call every third night. Mitigating the effects of sleep loss, circadian misalignment, and sleep inertia requires an understanding of the relationship among work schedules, fatigue, and job performance. This article reviews the current Accreditation Council for Graduate Medical Education guidelines for resident duty hours, examines how anesthesiologists' work schedules can affect job performance, and discusses the ramifications of overnight and prolonged duty hours on patient safety and resident well-being...
October 17, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29031926/monitoring-driver-fatigue-using-a-single-channel-electroencephalographic-device-a-validation-study-by-gaze-based-driving-performance-and-subjective-data
#12
José M Morales, Carolina Díaz-Piedra, Héctor Rieiro, Joaquín Roca-González, Samuel Romero, Andrés Catena, Luis J Fuentes, Leandro L Di Stasi
Driver fatigue can impair performance as much as alcohol does. It is the most important road safety concern, causing thousands of accidents and fatalities every year. Thanks to technological developments, wearable, single-channel EEG devices are now getting considerable attention as fatigue monitors, as they could help drivers to assess their own levels of fatigue and, therefore, prevent the deterioration of performance. However, the few studies that have used single-channel EEG devices to investigate the physiological effects of driver fatigue have had inconsistent results, and the question of whether we can monitor driver fatigue reliably with these EEG devices remains open...
October 12, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29031513/effective-cues-for-accelerating-young-drivers-time-to-transfer-control-following-a-period-of-conditional-automation
#13
Timothy J Wright, Ravi Agrawal, Siby Samuel, Yuhua Wang, Shlomo Zilberstein, Donald L Fisher
OBJECTIVE: During conditional automated driving, a transition from the automated driving suite to manual control requires the driver to take over control at a moment's notice. Thus, it is critical that a driver be made situationally aware as quickly as possible in those conditions where he or she may not be paying full attention. Recent research suggests that specific cues about upcoming hazards (e.g., "crosswalk ahead") can increase the drivers' situation awareness during these safety-critical take-over situations when compared with a general cue ("take over control")...
October 11, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29030530/quality-of-medicines-in-portugal-a-retrospective-review-of-medicine-recalls-2005-2015
#14
Ana Reis, Bruna Berardo, Rui Loureiro
INFARMED, the Portuguese national health authority, alerts the general public and healthcare professionals about quality or safety issues detected in health products. The present study analyses substandard medicines recalls in Portugal between 2005 and 2015. All 338 alerts for medicine recalls were analysed, which represents a total of 378 drugs withdrawn. Despite the fact that the total number of medicine alerts has increased during the past decade, the number of actual medicine recalls remained relatively constant...
October 12, 2017: PDA Journal of Pharmaceutical Science and Technology
https://www.readbyqxmd.com/read/29025203/impact-of-targeted-education-on-managing-warning-and-error-signals-by-children-and-adolescents-with-type-1-diabetes-using-the-accu-chek-combo-insulin-pump-system
#15
Asma Deeb, Nabras Al Qahtani, Amal Al Ali, Mariette Akle
PURPOSE: Insulin pumps are widely used in diabetes. They are equipped with safety alarms to alert users. Pump manuals contain alarm codes and how to troubleshoot them. However, these manuals are lengthy and difficult to use, particularly in emergencies. We aim to assess the impact of targeted education on warnings and errors in improving competency to troubleshoot the alarms. METHODS: Twenty-one patients, with a median age of 13, were recruited over a 5-month period...
September 2017: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29025037/association-between-workarounds-and-medication-administration-errors-in-bar-code-assisted-medication-administration-in-hospitals
#16
Willem van der Veen, Patricia M L A van den Bemt, Hans Wouters, David W Bates, Jos W R Twisk, Johan J de Gier, Katja Taxis
Objective: To study the association of workarounds with medication administration errors using barcode-assisted medication administration (BCMA), and to determine the frequency and types of workarounds and medication administration errors. Materials and Methods: A prospective observational study in Dutch hospitals using BCMA to administer medication. Direct observation was used to collect data. Primary outcome measure was the proportion of medication administrations with one or more medication administration errors...
August 22, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28994307/alert-workplace-from-healthcare-workers-perspective-behavioral-and-environmental-strategies-to-improve-vigilance-and-alertness-in-healthcare-settings
#17
Rana Sagah Zadeh, Mardelle Shepley, Hessam Sadatsafavi, Arthur Hamie Owora, Ana C Krieger
OBJECTIVE: This study aims to identify the behavioral and environmental strategies that healthcare workers view as helpful for managing sleepiness, improving alertness, and therefore optimizing workplace safety. BACKGROUND: Reduced alertness is a common issue in healthcare work environments and is associated with impaired cognitive performance and decision-making ability as well as increased errors and injuries. METHOD: We surveyed 136 healthcare professionals at a primary care clinic, an acute care hospital, and a mental health clinic...
January 1, 2017: HERD
https://www.readbyqxmd.com/read/28991718/improving-treatment-times-for-patients-with-in-hospital-stroke-using-a-standardized-protocol
#18
Junpei Koge, Shoji Matsumoto, Ichiro Nakahara, Akira Ishii, Taketo Hatano, Nobutake Sadamasa, Yasutoshi Kai, Mitsushige Ando, Makoto Saka, Hideo Chihara, Wataru Takita, Keisuke Tokunaga, Takahiko Kamata, Hidehisa Nishi, Tetsuya Hashimoto, Atsushi Tsujimoto, Jun-Ichi Kira, Izumi Nagata
BACKGROUND: Previous reports have shown significant delays in treatment of in-hospital stroke (IHS). We developed and implemented our IHS alert protocol in April 2014. We aimed to determine the influence of implementation of our IHS alert protocol. METHODS: Our implementation processes comprise the following four main steps: IHS protocol development, workshops for hospital staff to learn about the protocol, preparation of standardized IHS treatment kits, and obtaining feedback in a monthly hospital staff conference...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28988252/drug-shortages-in-large-hospitals-in-riyadh-a-cross-sectional-study
#19
Yazed Sulaiman AlRuthia, Hadeel AlKofide, Refaa'h AlAjmi, Bander Balkhi, Ahmed Alghamdi, Albandari AlNasser, Areej Alayed, Maali Alshammari, Danah Alsuhaibani, Asma Alathbah
BACKGROUND: Drug shortages are a serious and complex issue in any healthcare system. We conducted this study because the prevalence of drug shortages in Saudi Arabia is largely unknown, while there have been reports of shortages. OBJECTIVE: To explore the prevalence and characteristics of drug shortages as well as identify strategies to minimize their impact on patient care and safety in large hospitals. DESIGN: Questionnaire-based cross-sectional study...
September 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/28980025/-the-working-group-of-enforcement-officers-wgeo-the-european-network-of-drug-regulatory-authorities-to-combat-pharmaceutical-crime
#20
REVIEW
Marcus Wittstock, Renz Streit
Ten years ago the Heads of Medicines Agencies (HMA) officially founded the Working Group of Enforcement Officers (WGEO), a European working group to reduce falsifications of human and veterinarian medicinal products in the legal and illegal supply chain. Police, customs and other international organisations are also represented in the WGEO. Partner organisations are for example the Directorate General for Health and Food Safety of the European Commission, the European Medicines Agency (EMA), the European Police Office (Europol), the International Criminal Police Organization (Interpol), the European Directorate for the Quality of Medicines and Healthcare (EDQM) and the World Health Organization (WHO)...
October 4, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
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