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https://www.readbyqxmd.com/read/28910196/effect-of-alpinia-galanga-on-mental-alertness-and-sustained-attention-with-or-without-caffeine-a-randomized-placebo-controlled-study
#1
Shalini Srivastava, Mark Mennemeier, Surekha Pimple
OBJECTIVE: Although Alpinia galanga has been reported to improve cognitive performance in animals, it has not been thoroughly studied for its potential psychostimulant effect in humans. A randomized, double-dummy, double-blind, placebo-controlled cross-over study was conducted to determine the effect of A galanga on mental alertness and sustained attention in comparison with caffeine and placebo in participants with a habitual caffeine intake. METHODS: Fifty-nine participants (18-40 years and body mass index of ≥18...
September 14, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28899924/relationship-between-ugt1a9-gene-polymorphisms-efficacy-and-safety-of-propofol-in-induced-abortions-among-a-chinese-population-a-population-based-study
#2
Ying-Bin Wang, Rong-Zhi Zhang, Sheng-Hui Huang, Shu-Bao Wang, Jian-Qin Xie
This study aimed to investigate the influence of UGT1A9 gene polymorphisms on the efficacy of propofol in patients undergoing the painless induced abortion method. A total of 156 women seeking voluntary pregnancy termination procedures were selected for the study, and subsequently underwent painless induced abortions, following anesthesia by means of propofol administration. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed to detect the polymorphisms of UGT1A9 gene at -440C/T, -1818C/T and -1887T/G loci...
September 12, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28895672/meat-and-meat-products-%C3%A2-analysis-of-the-most-common-threats-in-the-years-2011-2015-in-rapid-alert-system-for-food-and-feed-rasff
#3
Anna D. Kononiuk, Małgorzata Karwowska
Background: The key tool used in the European Union in order to eliminate the risks associated with the consumption of potentially hazardous food is RASFF - Rapid Alert System for Food and Feed Safety. The RASFF was established to increase accountability and strengthening cooperation between states of the European Union in the field of food safety control. Objective: The aim of this study was to explore the trends and temporal and spatial distribution of notifications on food safety hazards between January 2011 and December 2015 with a special emphasis on meat and meat products on the basis of notification from RASFF...
2017: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/28891839/the-relative-effects-of-dexmedetomidine-and-propofol-on-cerebral-blood-flow-velocity-and-regional-brain-oxygenation-a-randomised-noninferiority-trial
#4
Ehab Farag, Michael Kot, Attila Podolyak, Maged Argalious, Milind Deogaonkar, Edward J Mascha, Zekun Xu, Irene Katzan, Zeyd Ebrahim
BACKGROUND: Dexmedetomidine constricts cerebral blood vessels without a concomitant reduction in cerebral metabolic oxygen consumption. Its safety as a sedative in patients with neurological diseases thus remains uncertain. OBJECTIVE: Our primary objective was to test the hypothesis that dexmedetomidine is noninferior to propofol as regards cerebral blood flow (CBF) velocity and brain oxygenation. DESIGN: Unblinded randomised trial. SETTING: Cleveland Clinic Hospital, Cleveland, from November 2010 to July 2013...
June 19, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28886141/the-impact-of-vehicle-moving-violations-and-freeway-traffic-flow-on-crash-risk-an-application-of-plugin-development-for-microsimulation
#5
Junhua Wang, Yumeng Kong, Ting Fu, Joshua Stipancic
This paper presents the use of the Aimsun microsimulation program to simulate vehicle violating behaviors and observe their impact on road traffic crash risk. Plugins for violations of speeding, slow driving, and abrupt stopping were developed using Aimsun's API and SDK module. A safety analysis plugin for investigating probability of rear-end collisions was developed, and a method for analyzing collision risk is proposed. A Fuzzy C-mean Clustering algorithm was developed to identify high risk states in different road segments over time...
2017: PloS One
https://www.readbyqxmd.com/read/28873717/herbal-products-containing-hibiscus-sabdariffa-l-crataegus-spp-and-panax-spp-labeling-and-safety-concerns
#6
Maria Antónia Nunes, Francisca Rodrigues, Rita C Alves, Maria Beatriz P P Oliveira
Herbs have been used from ancient times for infusion preparation based on their potential health effects. In particular, the consumption of Hibiscus sabdariffa L., Crataegus spp. and Panax spp. has been largely associated to cardiovascular benefits. In this work, the label information of 52 herbal products for infusion preparation containing the referred herbs was analyzed and discussed, taking into consideration the European Union regulation for herbal products, which intends to protect public health and harmonize the legal framework in Member States...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28873551/are-tropane-alkaloids-present-in-organic-foods-detection-of-scopolamine-and-atropine-in-organic-buckwheat-fagopyron-esculentum-l-products-by-uhplc-ms-ms
#7
Martina Cirlini, Teresa M Demuth, Alberto Biancardi, Michael Rychlik, Chiara Dall'Asta, Renato Bruni
A closer monitoring of tropane alkaloids (TA) in foods is now recommended by the European Commission, following a series of alerts related to the contamination of buckwheat with weeds of the genus Datura. A novel, accurate UHPLC-MS/MS method was developed and validated for the rapid detection of scopolamine and atropine in buckwheat foods. A suitable extraction protocol was set up to maximize recoveries and detection limits in different raw, processed and baked foods. The method offers good performances in terms of sensitivity, accuracy and precision, with LOQs at 0...
January 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28872096/clinical-reappraisal-of-vasculobiliary-anatomy-relevant-to-laparoscopic-cholecystectomy
#8
Kuldip Singh, Ranbir Singh, Manjot Kaur
BACKGROUND: Laparoscopic cholecystectomy (LC) has many advantages as compared to open cholecystectomy. However, vasculobiliary injuries still continue to be a matter of concern despite advances in laparoscopic techniques. Misidentification and misperception of vasculobiliary structures is considered to be a pivotal factor leading to injuries. Although many studies since time immemorial have stressed on the importance of anatomy, an insight into laparoscopic anatomy is what essentially constitutes the need of the hour...
October 2017: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/28868599/diving-with-pre-existing-medical-conditions
#9
John Lippmann, David McD Taylor, Christopher Stevenson, Jo Williams, Simon J Mitchell
INTRODUCTION: This is the second report based on a survey of Divers Alert Network Asia-Pacific (DAN AP) members who dive with cardiovascular and respiratory conditions and diabetes. It examines the medical management of the divers' conditions, any diving modifications used to mitigate the risk and outcomes. METHODOLOGY: An online cross-sectional survey was sent to 833 divers who had declared a targeted medical condition when applying for DAN AP membership between July 2009 and August 2013...
September 2017: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/28841099/survey-of-guidelines-and-current-practices-for-safe-handling-of-antineoplastic-and-other-hazardous-drugs-used-in-24-countries
#10
Patricia I Mathias, Barbara A MacKenzie, Christine A Toennis, Thomas H Connor
Purpose A survey of guidelines and current practices was conducted to examine the safe handling procedures for antineoplastic and other hazardous drugs that are used in 24 countries including the Americas, Europe, the Mideast, Far East, and Australia. Methods Subject experts were asked to complete a brief survey regarding safe handling guidelines and practices for hazardous drugs in their countries. Questions addressed practices for handling monoclonal antibodies, the use of closed-system transfer devices, medical surveillance practices, and measurements of compliance with existing guidelines...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/28832067/comparison-of-overridden-medication-related-clinical-decision-support-in-the-intensive-care-unit-between-a-commercial-system-and-a-legacy-system
#11
Adrian Wong, Adam Wright, Diane L Seger, Mary G Amato, Julie M Fiskio, David Bates
BACKGROUND: Electronic health records (EHRs) with clinical decision support (CDS) have shown to be effective at improving patient safety. Despite this, alerts delivered as part of CDS are overridden frequently, which is of concern in the critical care population as this group may have an increased risk of harm. Our organization recently transitioned from an internally-developed EHR to a commercial system. Data comparing various EHR systems, especially after transitions between EHRs, are needed to identify areas for improvement...
August 23, 2017: Applied Clinical Informatics
https://www.readbyqxmd.com/read/28817503/interprovider-communication-using-a-scheduled-provider-alert-response-communication-system-in-3-inpatient-neurology-units
#12
James E Siegler, Dan Finegan, Scott E Kasner, Raymond S Price
BACKGROUND: Nonemergent communications between nursing staff and residents often occur randomly throughout the workday at teaching institutions, resulting in inefficiency and interruptions of scheduled resident educational conferences or periods of overnight rest. OBJECTIVE: The aim of this study was to determine whether a quality improvement communication strategy can reduce interruptive notifications during scheduled resident didactic sessions. METHODS: We conducted a prospective, mixed-methods trial of a communication strategy between nurses and residents in 3 neurology units of an academic institution...
August 16, 2017: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
https://www.readbyqxmd.com/read/28808942/primary-care-providers-opening-of-time-sensitive-alerts-sent-to-commercial-electronic-health-record-inbaskets
#13
Sarah L Cutrona, Hassan Fouayzi, Laura Burns, Rajani S Sadasivam, Kathleen M Mazor, Jerry H Gurwitz, Lawrence Garber, Devi Sundaresan, Thomas K Houston, Terry S Field
BACKGROUND: Time-sensitive alerts are among the many types of clinical notifications delivered to physicians' secure InBaskets within commercial electronic health records (EHRs). A delayed alert review can impact patient safety and compromise care. OBJECTIVE: To characterize factors associated with opening of non-interruptive time-sensitive alerts delivered into primary care provider (PCP) InBaskets. DESIGN AND PARTICIPANTS: We analyzed data for 799 automated alerts...
August 14, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28804707/framework-to-define-structure-and-boundaries-of-complex-health-intervention-systems-the-alert-project
#14
Elena Boriani, Roberto Esposito, Chiara Frazzoli, Peter Fantke, Tine Hald, Simon R Rüegg
Health intervention systems are complex and subject to multiple variables in different phases of implementation. This constitutes a concrete challenge for the application of translational science in real life. Complex systems as health-oriented interventions call for interdisciplinary approaches with carefully defined system boundaries. Exploring individual components of such systems from different viewpoints gives a wide overview and helps to understand the elements and the relationships that drive actions and consequences within the system...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28771933/impact-of-clinical-evidence-communications-and-drug-regulation-changes-concerning-rosiglitazone-on-prescribing-patterns-of-antidiabetic-therapies
#15
Yoojin Noh, Dae Ryong Kang, Dae Jung Kim, Kwang Jae Lee, Sukhyang Lee, Sooyoung Shin
PURPOSE: Cardiovascular safety alerts about rosiglitazone resulted in regulatory actions in several countries in 2010, but the Food and Drug Administration eliminated access restrictions in 2013, reflecting new evidence concerning the drug safety. We investigated the effects of safety signals and regulation shifts concerning rosiglitazone on prescribing of antidiabetic drugs (ADs). METHODS: Patient data were extracted from the Korean health insurance claims database for 2007 to 2015...
August 3, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28770543/feasibility-and-safety-of-virtual-reality-based-early-neurocognitive-stimulation-in-critically-ill-patients
#16
Marc Turon, Sol Fernandez-Gonzalo, Mercè Jodar, Gemma Gomà, Jaume Montanya, David Hernando, Raquel Bailón, Candelaria de Haro, Victor Gomez-Simon, Josefina Lopez-Aguilar, Rudys Magrans, Melcior Martinez-Perez, Joan Carles Oliva, Lluís Blanch
BACKGROUND: Growing evidence suggests that critical illness often results in significant long-term neurocognitive impairments in one-third of survivors. Although these neurocognitive impairments are long-lasting and devastating for survivors, rehabilitation rarely occurs during or after critical illness. Our aim is to describe an early neurocognitive stimulation intervention based on virtual reality for patients who are critically ill and to present the results of a proof-of-concept study testing the feasibility, safety, and suitability of this intervention...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28768695/%C3%A2-strontium-ranelate-discontinued
#17
(no author information available yet)
▼ Strontium ranelate discontinued ● Limited treatment options for molluscum contagiosum ● Finasteride drug safety alert ● Does doxycycline delay the next COPD exacerbation? ● Support for WHO standards on reporting clinical trial results ● Delayed antibiotic prescription for lower respiratory tract infections ● Nystatin dose change - much ado about nothing?
August 2, 2017: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/28768691/finasteride-drug-safety-alert
#18
(no author information available yet)
No abstract text is available yet for this article.
August 2, 2017: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/28760141/pharmacovigilance-in-israel-tools-processes-and-actions
#19
Eyal Schwartzberg, Matitiahu Berkovitch, Dorit Dil Nahlieli, Joseph Nathan, Einat Gorelik
BACKGROUND: Due to the limited safety data available at the time that a new medication is first marketed, it is essential to continue the collection and monitoring of safety data about adverse drug reactions (ADRs) during the medication's life cycle. This activity, known as pharmacovigilance (PV), is performed worldwide by the pharmaceutical industry as well as by regulatory agencies. In 2012, the Israeli Ministry of Health (MOH) established a Pharmacovigilance and Drug Information Department...
August 1, 2017: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/28758270/prescription-drug-use-during-pregnancy-in-france-a-study-from-the-national-health-insurance-permanent-sample
#20
Romain Demailly, Sylvie Escolano, Catherine Quantin, Pascale Tubert-Bitter, Ismaïl Ahmed
PURPOSE: To provide an up-to-date account of drug prescription during pregnancy in France from 2011 to 2014 using the permanent sample of the French national computerized healthcare database and with a focus on recommended supplementations, fetotoxic drugs and teratogenic drugs. METHODS: All pregnancies identified by the International Classification of Diseases, 10th Revision codes list in the hospitalization database, lasting more than 9 weeks of amenorrhea and whose delivery occurred between 01/01/2011 and 12/31/2014, were included...
July 30, 2017: Pharmacoepidemiology and Drug Safety
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