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https://www.readbyqxmd.com/read/28797102/uterotubal-junction-prevents-chlamydial-ascension-via-innate-immunity
#1
Yuyang Zhang, Lili Shao, Xiaodong Li, Guangming Zhong
Ascension to the oviduct is necessary for Chlamydia to induce tubal infertility. Using the Chlamydia muridarum induction of hydrosalpinx mouse model, we have demonstrated a significant role of the uterotubal junction in preventing chlamydial ascending infection. First, delivery of C. muridarum to either side of the uterotubal junction resulted in significant reduction in live organisms from the tissues on the opposite sides. However, the recovery yields remained similar among different sections of the uterine horn...
2017: PloS One
https://www.readbyqxmd.com/read/28770172/diversity-of-cervical-microbiota-in-asymptomatic-chlamydia-trachomatis-genital-infection-a-pilot-study
#2
Simone Filardo, Marisa Di Pietro, Maria G Porpora, Nadia Recine, Alessio Farcomeni, Maria A Latino, Rosa Sessa
Chlamydia trachomatis genital infection continues to be an important public health problem worldwide due to its increasing incidence. C. trachomatis infection can lead to severe sequelae, such as pelvic inflammatory disease, obstructive infertility, and preterm birth. Recently, it has been suggested that the cervico-vaginal microbiota may be an important defense factor toward C. trachomatis infection as well as the development of chronic sequelae. Therefore, the investigation of microbial profiles associated to chlamydial infection is of the utmost importance...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28744742/the-primary-result-of-prospective-randomized-multicenter-trial-of-new-spray-type-bio-absorbable-adhesion-barrier-system-tcd-11091-against-postoperative-adhesion-formation
#3
Takeshi Suto, Masahiko Watanabe, Takeshi Endo, Koji Komori, Masayuki Ohue, Yukihide Kanemitsu, Masaaki Itou, Yasumasa Takii, Toshimasa Yatsuoka, Manabu Shiozawa, Tetsushi Kinugasa, Hideki Ueno, Tadatoshi Takayama, Tadahiko Masaki, Hiroyuki Masuko, Hisanaga Horie, Masafumi Inomata
BACKGROUND: Postoperative adhesions are the major cause of postoperative complications including intestinal obstruction, infertility, and chronic pelvic pain. In order to reduce postoperative adhesions, Terumo Corporation (Tokyo, Japan) has developed an adhesion barrier system (TCD-11091) which is easy to use at the treatment site in various surgical procedures including laparoscopic surgeries. We conducted a prospective randomized single-blind study in patients who underwent laparotomy with ileostomy...
July 25, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28736365/-blighted-ovum-in-subfertile-patients-undergoing-assisted-reproductive-technology
#4
Qing-Wen Nie, Rui Hua, Yao Zhou, Hong Li, Yan-Hong Yu
OBJECTIVE: To explore the incidence and risk factors of blighted ovum in subfertile patients undergoing assisted reproductive technology (ART). METHODS: This retrospective analysis was conducted among 2378 patients who were pregnant following embryo transfer at our center from January, 2012 to December, 2015, including cases of early pregnancy losses and simultaneous live births. The cases with early pregnancy losses were divided into embryonic pregnancy and blighted ovum groups based on the presence or absence of an embryonic pole before dilation and curettage...
July 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28730893/multicenter-study-of-genetic-abnormalities-associated-with-severe-oligospermia-and-non-obstructive-azoospermia
#5
Chong Xie, Xiangfeng Chen, Yulin Liu, Zhengmu Wu, Ping Ping
Objective * Chong Xie, Xiangfeng Chen, and Yulin Liu contributed equally to this work. Genetic defects are identified in nearly 20% of infertile males. Determining the frequency and types of major genetic abnormalities in severe male infertility helps inform appropriate genetic counseling before assisted reproductive techniques. Methods Cytogenetic results of 912 patients with non-obstructive azoospermia (NOA) and severe oligozoospermia (SOS) in Eastern China were reviewed in this multicenter study from January 2011 to December 2015...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28729464/mir-15a-5p-levels-correlate-with-poor-ovarian-response-in-human-follicular-fluid
#6
Kaiyue Zhang, Wanxia Zhong, Wei-Ping Li, Zijiang Chen, Cong Zhang
Poor ovarian response is a significant problem encountered during in vitro fertilization and embryo transfer procedures. Many infertile women may suffer from poor ovarian response and its incidence tends to be increasing in young patients nowadays. It is a major cause of maternal infertility because it is associated with low pregnancy and live birth rates. However, the cause of poor ovarian response is not clear. In this study, we extracted microRNAs from human follicular fluid and performed miRNA sequencing to investigate a potential posttranscriptional mechanism underlying poor ovarian response...
July 20, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28718528/impairment-of-sperm-dna-methylation-in-male-infertility-a-meta-analytic-study
#7
D Santi, S De Vincentis, E Magnani, G Spaggiari
Considering the widespread use of assisted reproductive techniques (ART), DNA methylation of specific genes involved in spermatogenesis achieves increasingly clinical relevance, representing a possible explanation of increased incidence of syndromes related to genomic imprinting in medically assisted pregnancies. Several trials suggested a relationship between male sub-fertility and sperm DNA methylation, although its weight on seminal parameters alteration is still a matter of debate. To evaluate whether aberrant sperm DNA methylation of imprinted genes is associated with impaired sperm parameters...
July 2017: Andrology
https://www.readbyqxmd.com/read/28715980/clinical-aspects-of-infertile-47-xyy-patients-a-retrospective-study
#8
Parnaz Borjian Boroujeni, Marjan Sabbaghian, Ahmad Vosough Dizaji, Shabnam Zarei Moradi, Navid Almadani, Faranak Mohammadpour Lashkari, Mohamad Reza Zamanian, Anahita Mohseni Meybodi
47,XYY syndrome is a sex chromosomal anomaly in men, which may be associated with infertility and has an incidence of 0.1% of male births. The clinical and paraclinical characteristics of men suffering from this anomaly have not been fully described. In this retrospective study, we present 37 cases of 47,XYY infertile men with sperm counts varying from normal to azoospermia, referred to the Genetics Laboratory at the Royan Institute, Iran. Thirteen individuals were mosaic and 24 non-mosaics. Non-mosaic patients were classified as azoospermic (nine cases) and normospermic/oligozoospermic men (15 cases)...
July 18, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28706367/diagnostic-office-vaginohysteroscopy-in-evaluation-of-infertility-prior-to-ivf-a-retrospective-analysis-of-1000-cases
#9
Praveen Kumar, Surender Mohan, Pankaj Talwar, Seema Rai, N Nagaraja, Prashant Sharma
AIM: The aim of this study was to analyze the utility of routine use of diagnostic office vaginohysteroscopy in the evaluation of uterine cavity in infertility patients prior to IVF-ET. MATERIALS AND METHODS: We conducted a retrospective analysis of 1000 women who had undergone routine diagnostic office vaginohysteroscopy as an institutional protocol in the evaluation of infertility prior to IVF-ET cycle at a tertiary care hospital. They were divided into two groups: primary infertility (group I) and secondary infertility (group II)...
August 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/28698074/fertiloscopy-improves-in-vitro-fertilization-for-women-with-repeated-implantation-failure
#10
R Zhang, A Xu, Q Wang, L Zhang, L Zhu, S Zhao, W Xiong
OBJECTIVE: To assess the effects of fertiloscopy procedure on the outcomes of subsequent in vitro fertilization cycles in patients with repeated implantation failure (RIF). METHODS: A retrospective study was performed on 50 patients underwent fertiloscopy and 41 controls with RIF. Pelvic and intrauterine pathologies related to infertility, clinical pregnancy rate (CPR) and ongoing pregnancy rate (OPR) of subsequent IVF cycles were assessed. RESULTS: Twenty-six out of 50 patients (52%) had abnormal fertiloscopic findings...
July 8, 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/28697910/duphaston-and-human-menopausal-gonadotropin-protocol-in-normally-ovulatory-women-undergoing-controlled-ovarian-hyperstimulation-during-in%C3%A2-vitro-fertilization-intracytoplasmic-sperm-injection-treatments-in-combination-with-embryo-cryopreservation
#11
Xiuxian Zhu, Hongjuan Ye, Yonglun Fu
OBJECTIVE: To evaluate endocrine characteristics and clinical outcomes in normal ovulatory patients undergoing controlled ovarian hyperstimulation (COH) with the use of a Duphaston and hMG protocol during in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatments in combination with frozen-thawed embryo transfer (FET) compared with the characteristics and outcomes of patients undergoing an Utrogestan and hMG protocol. DESIGN: Prospective controlled study...
July 8, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28693619/successful-pregnancy-after-mucinous-cystic-neoplasm-with-invasive-carcinoma-of-the-pancreas-in-a-patient-with-polycystic-ovarian-syndrome-a-case-report
#12
Conisha Holloman, S J Carlan, Lohini Sundharkrishnan, Angela Guzman, Mario Madruga
BACKGROUND: The incidence of invasive cancer within a mucinous cystic neoplasm of the pancreas varies between 6 and 36%. Polycystic ovarian syndrome is a disorder characterized by hyperandrogenism and anovulatory infertility. One surgical treatment that can restore endocrine balance and ovulation in polycystic ovarian syndrome is partial ovarian destruction. Successful pregnancies following preconception pancreaticoduodenectomies (Whipple procedures) and chemoradiation to treat pancreatic neoplasms have been reported rarely but none were diagnosed with pre-cancer polycystic ovarian syndrome-associated infertility...
July 11, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28670432/relationship-between-chlamydia-ureaplasma-mycoplasma-genital-detection-with-semen-concentration-and-motility-among-greek-men
#13
Ageliki Gerovassili, Ourania Marcandona, Byron Asimakopoulos, Vasilis Karavasilis, Maria Panopoulou, Alexandros Ikonomidis
One hundred and seventy two men at the State of Thessaly, Greece, inquiring semen analysis were enrolled in the study in order to investigate the incidence of Chlamydia, Ureaplasma and Mycoplasma (C-U-M) genera in respect to total sperm number (TSN), progressive motility (grades a and b) and total motility (grades a, b and c). Putative relation of C-U-M acquirement with sexual behavior was also investigated. Incidence of C-U-M among non-oligozoospermic and oligozoospermic men was similar. Νο correlation of C-U-M carriage to either oligozoospermia or asthenozoospermia was found...
July 2017: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/28656917/to-compare-aneuploidy-rates-between-icsi-and-ivf-cases
#14
L Sahin, M Bozkurt, H Şahin, A Gürel, E Calıskan
INTRODUCTION: Intracytoplasmic sperm injection (ICSI) currently helps many couples with male infertility. However, ICSI procedure may cause asynchronous sperm decondensation. This could introduce a risk for aneuploidy. The ICSI technique also could cause damage to the second meiotic spindle during injection and cause significantly abnormal pairing of chromosomes when compared with In vitro fertilization (IVF). In this study, we have examined whether ICSI has a higher incidence of aneuploidy when compared with IVF...
June 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28638108/pregnancy-outcomes-in-nulliparous-women-after-ultrasound-ablation-of-uterine-fibroids-a-single-central-retrospective-study
#15
Jun Shu Li, Yong Wang, Jin Yun Chen, Wen Zhi Chen
To explore the impact of high-intensity focused ultrasound (HIFU) ablation of uterine fibroids in nulliparous women on subsequent pregnancy and delivery. A retrospective analysis was conducted of nulliparous women who received HIFU treatment at Chongqing Medical University, Chongqing,China, from January 1, 2010, to January 1, 2015. A total of 189 cases were enrolled, the median follow-up time was three years. Among them,there were 131 cases pregnancy with a total of 133 times,the pregnancy rate was 69.3% (131/189),and the spontaneous conception rate was 95...
June 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28632112/the-2016-european-guideline-on-the-management-of-epididymo-orchitis
#16
Emma J Street, Edwin D Justice, Zsolt Kopa, Mags D Portman, Jonathan D Ross, Mihael Skerlev, Janet D Wilson, Rajul Patel
Epididymo-orchitis is a commonly encountered condition with a reported incidence of 2.45 cases per 1000 men in the United Kingdom. This 2016 International Union against Sexually Transmitted Infections guideline provides up-to-date advice on the management of this condition. It describes the aetiology, clinical features and potential complications, as well as presenting diagnostic considerations and clear recommendations for management and follow-up. Early diagnosis and management are essential, as serious complications can include abscess formation, testicular infarction and infertility...
July 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28609278/do-women-offered-assisted-reproduction-technologies-have-a-higher-incidence-of-gynecologic-cancer-a-systematic-review-and-meta-analysis
#17
REVIEW
Juan Enrique Schwarze, Paulina Valdebenito, Carolina Ortega, Sonia Villa, Javier Crosby, Ricardo Pommer
The last two decades have seen an increase in the number of women diagnosed with infertility. The consequent growth in the use of assisted reproductive technologies (ART) calls for the determination of its long-term effects, including the risk of cancer. Many studies have attempted to answer this question, albeit with contradictory results. This review aimed to assess whether assisted reproductive technologies are associated with an increased risk of gynecological cancer. A search for papers in the literature was carried out on MEDLINE, TRIP DATABASE and NICE, resulting in 11 studies enrolling 3,900,231 patients altogether...
June 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28600105/ovarian-stimulation-and-risk-of-breast-cancer-in-swedish-women
#18
Frida E Lundberg, Anastasia N Iliadou, Kenny Rodriguez-Wallberg, Christina Bergh, Kristina Gemzell-Danielsson, Anna L V Johansson
OBJECTIVE: To investigate whether ovarian stimulation for treating infertility is associated with the risk of breast cancer. DESIGN: Nationwide register-based cohort study. SETTING: Not applicable. PATIENT(S): In a cohort of 1,340,211 women who gave birth 1982-2012, we investigated the relationship between assisted reproductive technology (ART) and incidence of breast cancer. Associations between any ovarian stimulation since 2005 and breast cancer incidence were studied in a separate cohort of 1,877,140 women born 1960-92...
July 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28570663/rectal-administration-of-a-chlamydial-subunit-vaccine-protects-against-genital-infection-and-upper-reproductive-tract-pathology-in-mice
#19
Roshan Pais, Yusuf Omosun, Qing He, Uriel Blas-Machado, Carolyn Black, Joseph U Igietseme, Kohtaro Fujihashi, Francis O Eko
In this study, we tested the hypothesis that rectal immunization with a VCG-based chlamydial vaccine would cross-protect mice against heterologous genital Chlamydia trachomatis infection and Chlamydia-induced upper genital tract pathologies in mice. Female mice were immunized with a C. trachomatis serovar D-derived subunit vaccine or control or live serovar D elementary bodies (EBs) and the antigen-specific mucosal and systemic immune responses were characterized. Vaccine efficacy was determined by evaluating the intensity and duration of genital chlamydial shedding following intravaginal challenge with live serovar E chlamydiae...
2017: PloS One
https://www.readbyqxmd.com/read/28552246/the-incidence-of-long-heterochromatic-polymorphism-variants-in-infants-conceived-through-assisted-reproductive-technologies
#20
Andrew Wilson, Katherine Watt, Sai Ma
Long heterochromatic variants on chromosomes 1, 9, 16 and Y are suspected to be implicated in infertility and early pregnancy loss, but little is known about how these variants are inherited in children conceived by infertile couples through assisted reproductive technologies. In this case-control study, the incidence of these variants was compared between infants conceived using intracytoplasmic sperm injection (ICSI), IVF and natural intercourse by karyotyping lymphocytes from cord blood or peripheral blood...
May 15, 2017: Reproductive Biomedicine Online
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