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Incidence of infertility

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https://www.readbyqxmd.com/read/28324051/androgen-stimulates-growth-of-mouse-preantral-follicles-in-vitro-interaction-with-follicle-stimulating-hormone-and-with-growth-factors-of-the-tgf%C3%AE-superfamily
#1
Mhairi Laird, Kacie Thomson, Mark Fenwick, Jocelyn Mora, Stephen Franks, Kate Hardy
Androgens are essential for the normal function of mature antral follicles but also have a role in the early stages of follicle development. Polycystic ovary syndrome (PCOS), the commonest cause of anovulatory infertility, is characterized by androgen excess and aberrant follicle development that includes accelerated early follicle growth. We have examined the effects of testosterone and dihydrotestosterone (DHT) on development of isolated mouse preantral follicles in culture with the specific aims of investigating interaction with FSH, the steroidogenic pathway and with growth factors of the TGFβ superfamily that are known to have a role in early follicle development...
January 24, 2017: Endocrinology
https://www.readbyqxmd.com/read/28324041/line1-cpg-dna-hypomethylation-in-granulosa-cells-and-blood-leukocytes-is-associated-with-pcos-and-related-traits
#2
Pooja Sagvekar, Vijay Mangoli, Sadhana Desai, Anushree Patil, Srabani Mukherjee
CONTEXT: Altered global DNA methylation is indicative of epigenomic instability concerning chronic disease-states. Investigating its incidence and association with polycystic ovary syndrome (PCOS) is essential towards understanding the etiopathogenesis of this disorder. OBJECTIVES: To assess, global DNA methylation differences in peripheral blood leukocytes (PBLs) and cumulus granulosa cells (CGCs) of PCOS and controls and their association with PCOS and its traits...
January 9, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28302748/smc5-6-is-required-for-the-formation-of-segregation-competent-bivalent-chromosomes-during-meiosis-i-in-mouse-oocytes
#3
Grace Hwang, Fengyun Sun, Marilyn O'Brien, John J Eppig, Mary Ann Handel, Philip W Jordan
SMC complexes include three major classes: cohesin, condensin, and SMC5/6. However, the localization pattern and genetic requirements for the SMC5/6 complex during mammalian oogenesis had not previously been examined. In mouse oocytes, the SMC5/6 complex is enriched at the pericentromeric heterochromatin, and also localizes along chromosome arms during meiosis. The infertility phenotypes of females with a Zp3-Cre-driven conditional knockout (cKO) of Smc5 demonstrated that maternally expressed SMC5 protein is essential for early embryogenesis...
March 16, 2017: Development
https://www.readbyqxmd.com/read/28293058/ruptured-hemorrhagic-cyst-of-undescended-ovary-mimicking-mucocele-a-rare-pediatric-case
#4
Tamer Sekmenli, Metin Gündüz, Ilhan Ciftci
Undescended ovary is a rare entity and usually presentedas a case report. It is associated with urinary and uterine anomalies. Symptomatic patients are diagnosed during surgery. Most of the patients are asymptomatic and treatment is unnecessary. They are incidentally diagnosed during infertility evaluation and treatment such as ovarian hyperstimulation studies. A 15-year-old female patient presented with the diagnosis of renal cystic massas identifiedduring ultrasonography in another hospital. Abdominal computedtomography image was requested...
January 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28291647/health-professional-feedback-on-hpv-vaccination-roll-out-in-a-developing-country
#5
Collette Venturas, Kanayo Umeh
BACKGROUND: Worldwide, Zambia has the highest cervical cancer incidence rates (58.4/100,000 per year) and mortality rates (36.2/100,000 per year). The human papilloma virus (HPV) vaccine is considered a vital preventative measure against cervical cancer, particularly in sub-Saharan countries, such as Zambia. Past research suggests health professionals' experiences with HPV vaccination rollout can have practical implications for effective delivery. OBJECTIVE: To explore health professionals' perspectives on the HPV vaccination programme in Zambia...
March 10, 2017: Vaccine
https://www.readbyqxmd.com/read/28288431/non-art-pregnancy-predictive-factors-in-infertile-patients-with-peritoneal-superficial-endometriosis
#6
J Boujenah, I Cedrin-Durnerin, C Herbemont, C Sifer, C Poncelet
OBJECTIVE: To study the predictive factors for non-ART pregnancy in infertile women after laparoscopic diagnosis and surgery for isolated superficial peritoneal endometriosis (SUP). STUDY DESIGN: Retrospective observational study from January-2004 to December-2015 in a tertiary care university hospital and Assisted Reproductive Technology (ART) centre. Infertile women with laparoscopic surgery for SUP (with histologic diagnosis) were included. The surgical treatment was followed by spontaneous fertility or post-operative ovarian stimulation (pOS) using superovulation (gonadotrophins)±Intra Uterine Insemination (IUI)...
March 7, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28285952/ovarian-response-to-150%C3%A2-%C3%A2%C2%B5g-corifollitropin-alfa-in-a-gnrh-antagonist-multiple-dose-protocol-a-prospective-cohort-study
#7
Tamara Lerman, Marion Depenbusch, Askan Schultze-Mosgau, Soeren von Otte, Markus Scheinhardt, Inke Koenig, Axel Kamischke, Milan Macek, Arne Schwennicke, Sabine Segerer, Georg Griesinger
The incidence of low (<6 oocytes) and high (>18 oocytes) ovarian response to 150 µg corifollitropin alfa in relation to anti-Müllerian hormone (AMH) and other biomarkers was studied in a multi-centre (n = 5), multi-national, prospective, investigator-initiated, observational cohort study. Infertile women (n = 212), body weight >60 kg, underwent controlled ovarian stimulation in a gonadotrophin-releasing hormone-antagonist multiple-dose protocol. Demographic, sonographic and endocrine parameters were prospectively assessed on cycle day 2 or 3 of a spontaneous menstruation before the administration of 150 µg corifollitropin alfa...
March 2, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28280796/frequency-of-anti-chlamydia-trachomatis-antibodies-in-infertile-women-referred-to-tabriz-al-zahra-hospital
#8
Mahtab Sattari, Mehdi Ghiami Rad, Aaliye Ghasemzadeh, Zahra Mohammadoghli Reihan
BACKGROUND: Infertility is one of the major issues in society and its incidence is estimated to be almost 10-15%. Chlamydia trachomatis (C. trachomatis) is an important cause of sexually transmitted diseases leading to infertility. OBJECTIVE: This study was designed to determine the frequency of anti-C. trachomatis antibodies in infertile women at Al-zahra hospital, Tabriz, Iran. MATERIALS AND METHODS: In this cross-sectional study, the blood samples were collected randomly from 184 infertile women (case group) and 100 pregnant women (control group)...
January 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/28277124/letrozole-combined-with-low-dose-highly-purified-hmg-for-ovulation-induction-in-clomiphene-citrate-resistant-infertile-chinese-women-with-polycystic-ovary-syndrome-a-prospective-study
#9
Yue Zhao, Xiangyan Ruan, Alfred O Mueck
BACKGROUND AND AIM: There are still open questions about ovulation induction in clomiphene citrate-(CC)-resistant infertile women. Especially little is known about efficacy and safety of letrozole (LTZ) combined with low-dose highly purified human menopausal gonadotropin (Hp-HMG) in women with polycystic ovary syndrome (PCOS). METHODS: Prospective, single-arm single-center trial in 200 infertile PCOS patients refractory for at least three CC-treatment cycles. Women with hyperandrogenism took Diane-35 for at least 3 months...
February 28, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28276192/the-pregnancy-outcome-of-progesterone-primed-ovarian-stimulation-using-medroxyprogesterone-acetate4mg-versus-10mg-daily-in-infertile-women-undergoing-in-vitro-fertilization-a-randomized-controlled-trial
#10
J Dong, Y Wang, W R Chai, Q Q Hong, N L Wang, L H Sun, H Long, L Wang, H Tian, Q F Lyu, X F Lu, Q J Chen, Y P Kuang
OBJECTIVE: To investigate the clinical outcome and endocrinological characteristics of progestin-primed ovarian stimulation (PPOS) using medroxyprogesterone acetate (MPA) 4mg versus 10mg daily in infertile women with normal ovary reserve. DESIGN: A randomized parallel controlled trial. SETTING: Tertiary-care academic medical center. PARTICIPANTS: 300 infertile women undergoing IVF/ICSI treatment. METHODS: HMG 225IU/d and MPA (group A: 10mg/d; group B: 4mg/d) were started simultaneously from cycle day 3 onwards...
March 9, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28272720/the-efficacy-of-modified-luteal-phase-support-with-intramuscular-progesterone-in-ivf-icsi-cycles-a-retrospective-observational-study
#11
A Conforti, I Strina, A Mollo, R Amoroso, V Marrone, C Alviggi, R Marci, G de Placido
OBJECTIVE: The use of gonadotropin-releasing hormone agonist for ovulation triggering has become an intriguing topic in the last few years. As long as adequate luteal phase support is provided, it may be a valuable alternative to standard hCG triggering, associated with a significant reduction in OHSS incidence. Several luteal phase support options have been proposed, but few studies have addressed the issue of the appropriate route for progesterone administration to women triggered with GnRHa...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28264823/changing-trends-in-reproductive-lifestyle-factors-in-uk-women-descriptive-study-within-the-uk-collaborative-trial-of-ovarian-cancer-screening-ukctocs
#12
Aleksandra Gentry-Maharaj, Clara Glazer, Matthew Burnell, Andy Ryan, Hannah Berry, Jatinderpal Kalsi, Robert Woolas, Steve J Skates, Stuart Campbell, Mahesh Parmar, Ian Jacobs, Usha Menon
OBJECTIVE: There has been considerable interest in the impact of reproductive factors on health but there are little data on how these have varied over time. We explore trends in reproductive/lifestyle factors of postmenopausal British women by analysing self-reported data from participants of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). DESIGN: Prospective birth cohort analysis. SETTING: Population cohort invited between 2001 and 2005 from age-sex registers of 27 Primary Care Trusts in England, Wales and Northern Ireland and recruited through 13 National Health Service Trusts...
March 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28261628/partial-and-complete-microdeletions-of-y-chromosome-in-infertile-males-from-south-of-iran
#13
Raheleh Masoudi, Liusa Mazaheri-Asadi, Shahryar Khorasani
Y chromosome microdeletions are the second genetic cause of male infertility. The incidence of Y chromosome microdeletions can vary considerably depending on several factors, including patient selection criteria, population composition, and diagnostic protocols. They are associated with spermatogenic failure and lead to azoospermia or oligozoospermia. The advance in assisted reproductive technology and intracytoplasmic sperm injection, and the possibility of genetic defect transmission to the next generation make it necessary to improve our knowledge about the various factors leading to spermatogenic impairment...
December 2016: Molecular Biology Research Communications
https://www.readbyqxmd.com/read/28255605/an-epidemiological-study-on-vaginitis-in-6-150-women-of-reproductive-age-in-shanghai
#14
Haixia Wang, Zhonghua Huang, Zhaoxia Wu, Xulin Qi, Dongfang Lin
The aim of the present study was to determine the prevalence and risk factors for vaginitis, the proportion of pathogens, and cognition of reproductive age patients on the harmful effects of vaginitis, its risk factors, and treatment. This retrospective study enrolled 6,150 patients admitted to the Shanghai Jinshan Central Hospital from 2011 to 2015 with a chief complaint of abnormal vaginal discharge. A questionnaire was designed to survey the cognition of patients on the harmful effects of vaginitis. Routine gynecological examinations and laboratory tests were performed and the risk factors for contracting vaginitis were analyzed by multi-factor logistic regression analysis...
March 3, 2017: New Microbiologica
https://www.readbyqxmd.com/read/28248042/-comparative-effectiveness-of-marmar-technique-and-laparoscopic-clipping-of-testicular-vein-in-surgical-treatment-of-varicocele-in-athletes
#15
A S Samoylov, A G Martov, P S Kyzlasov, M V Zabelin, A A Kazhera
INTRODUCTION: Varicocele is one of the most common diseases among men and a proven cause of male infertility, which is directly proportional to its clinical prominence. The aim To evaluate the immediate and long-term outcomes of different surgical methods to treat varicocele in athletes. MATERIALS AND METHODS: A total of 165 athletes were treated for varicocele. Of them, 82 patients (group 1) underwent varicocele surgery using Marmar technique and 83 patients (group 2) were treated by laparoscopic clipping of testicular vein (endoscopic analogue of Ivanissevitch open surgery)...
December 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28243992/chemotherapy-induced-amenorrhea-and-the-resumption-of-menstruation-in-premenopausal-women-with-hormone-receptor-positive-early-breast-cancer
#16
Chinami Koga, Sayuri Akiyoshi, Mayumi Ishida, Yoshiaki Nakamura, Shinji Ohno, Eriko Tokunaga
BACKGROUND: For premenopausal women with breast cancer, information on the effects of chemotherapy and the risk of infertility is important. In this study, the effect of chemotherapy on the ovarian function in premenopausal women with hormone receptor-positive breast cancer was investigated, with an age-stratified analysis of the appearance of amenorrhea and the resumption of menstruation after the use of chemotherapy with anthracyclines or taxanes. PATIENTS AND METHODS: Premenopausal women diagnosed with operable Stage I-III hormone receptor-positive breast cancer and underwent neoadjuvant or adjuvant chemotherapy with the standard regimen of anthracyclines and/or taxanes were included...
February 27, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/28237328/parental-sex-effect-of-parthenogenesis-on-hatchability-and-sperm-egg-penetration-in-mated-chinese-painted-quail-coturnix-chinensis
#17
H M Parker, R Ramachandran, M Nascimento Dos Santos, A J Kawaoku, C R Wade, K D Lott, C D McDaniel
Selecting quail for an increased incidence of parthenogenesis also impacts egg weight and albumen pH as well as reduces hatchability and fertility due to decreased sperm-egg penetration (SEP). However, it is unknown which parental sex is responsible for these changes in quail selected for parthenogenesis. Therefore, the objective of this study was to determine which sex influences egg weight, albumen pH, hatchability, and SEP in birds selected for parthenogenesis. In this study, 2 lines of birds were used: 1 line that was selected for parthenogenesis and 1 line not selected for parthenogenesis (control)...
April 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28224638/assessment-of-human-sperm-dna-integrity-using-two-cytochemical-tests-acridine-orange-test-and-toluidine-blue-assay
#18
T Ajina, O Ammar, Z Haouas, A Sallem, L Ezzi, I Grissa, W Sakly, A Jlali, M Mehdi
Primary infertility affects approximately 15% of couples, with male factor infertility accounting for 50% of cases. Semen samples from 41 patients with asthenoteratospermia and 28 men with proven fertility were analysed according to World Health Organization guidelines. Abnormal sperm chromatin structure was assessed by toluidine blue assay (TBA), and DNA denaturation (DD) was detected by the acridine orange test (AOT). The mean (±SEM) rates of DD and abnormal chromatin structure were significantly higher in infertile subjects compared to fertile group respectively p = ...
February 22, 2017: Andrologia
https://www.readbyqxmd.com/read/28210478/the-twin-epidemic-in-infertility-care-why-do-we-persist-in-transferring-too-many-embryos
#19
EDITORIAL
W Ombelet
The epidemic of iatrogenic multiple births as a result of infertility treatment are responsible for an unacceptable high incidence of maternal, perinatal and childhood morbidity and mortality. Healthcare costs due to infertility therapy are too high and this may lead to social and political concern. The introduction of single embryo transfer (SET) was a real breakthrough, but was only accepted in most European countries and Japan. The United States, Latin America and most developing countries still have high multiple pregnancy rates...
December 2016: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/28179451/cushing-s-syndrome-in-children-and-adolescents-a-danish-nationwide-population-based-cohort-study
#20
Johanne Marie Holst, Erzsébet Horváth-Puhó, Rikke Beck Jensen, Mariane Rix, Kurt Kristensen, Niels Thomas Hertel, Olaf M Dekkers, Henrik Toft Sørensen, Anders Juul, Jens Otto L Jørgensen
OBJECTIVE: Cushing's syndrome (CS) affects all age groups, but epidemiologic data in young patients are very limited. We therefore examined the incidence, prevalence and hospital morbidity of CS in children and adolescents. DESIGN: In a nationwide cohort study, we included all Danish citizens aged 0-20 years from 1977 to 2012. Data were obtained from the Danish National Patient Registry using the International Classification of Diseases (ICD) codes and the Danish Civil Registration System...
May 2017: European Journal of Endocrinology
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