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Head neck oncology

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https://www.readbyqxmd.com/read/28077018/patient-factors-and-quality-of-life-outcomes-differ-among-four-subgroups-of-oncology-patients-based-on-symptom-occurrence
#1
Guro Lindviksmoen Astrup, Kristin Hofsø, Kristin Bjordal, Marianne Grønlie Guren, Ingvild Vistad, Bruce Cooper, Christine Miaskowski, Tone Rustøen
CONTEXT: Reviews of the literature on symptoms in oncology patients undergoing curative treatment, as well as patients receiving palliative care, suggest that they experience multiple, co-occurring symptoms and side effects. OBJECTIVES: The purposes of this study were to determine if subgroups of oncology patients could be identified based on symptom occurrence rates and if these subgroups differed on a number of demographic and clinical characteristics, as well as on quality of life (QoL) outcomes...
January 12, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28069153/working-in-silos-head-neck-cancer-patients-during-and-after-treatment-with-or-without-early-palliative-care-referral
#2
Helena Ullgren, Lily Kirkpatrick, Sini Kilpeläinen, Lena Sharp
PURPOSE: The primary aim was to describe patients with Head and Neck (H&N) cancer referred to palliative care and how the care transition from acute oncological to palliative care impacted on both Health related quality of life (HRQoL) and information. The secondary aim was to explore H&N cancer patients' HRQoL and perceived information. METHODS: H&N cancer patients were identified via the Swedish Cancer Register. Data were collected using the following questionnaires; European Organization for Research and Treatment of Cancer (EORTC) QLQ C-30, INFO25, and a study-specific questionnaire...
February 2017: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/28063277/straightforward-method-for-coverage-of-major-vessels-after-modified-radical-neck-dissection
#3
Raúl González-García, Carlos Moreno-García, Manuel Moreno-Sánchez, Leticia Román-Romero
A new method for covering the internal jugular vein and carotid artery after exposure of the cervical vascular axis subsequent to neck dissection is presented. To cover the most caudal part of the vascular axis, a platysma coli muscle flap is harvested from its most medial and inferior part of the neck in a caudally based fashion and is slightly rotated posteriorly up to 45°. In addition, a superiorly based sternocleidomastoid muscle flap involving the posterior half of the muscle after detachment of the clavicle head is harvested and rotated 45° anteriorly to cover the upper two thirds of the vascular axis...
December 15, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28061517/supraclavicular-flap-reconstruction-of-cutaneous-defects-has-lower-complication-rate-than-mucosal-defects
#4
Sameep Kadakia, Jay Agarwal, Moustafa Mourad, Sara Ashai, Thomas Lee, Yadranko Ducic
Background The objective of this study was to determine whether there was a difference in complication rate between cutaneous and mucosal defects reconstructed with the supraclavicular artery flap. Methods Retrospective review of postoperative complications in 63 patients from 2008 to 2015 with cutaneous and mucosal head and neck defects following oncologic ablation reconstructed with the supraclavicular flap, with a minimum follow-up duration of 6 months. Of the 63 patients, 38 patients had cutaneous defects, whereas 25 had mucosal defects...
January 6, 2017: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/28050201/neck-dissection-technique-commonality-and-variance-a-survey-on-neck-dissection-technique-preferences-among-head-and-neck-oncologic-surgeons-in-the-american-head-and-neck-society
#5
Shirin M Hemmat, Steven J Wang, William R Ryan
Introduction Neck dissection (ND) technique preferences are not well reported. Objective The objective of this study is to educate practitioners and trainees about surgical technique commonality and variance used by head and neck oncologic surgeons when performing a ND. Methods Online survey of surgeon members of the American Head and Neck Society (AHNS). Survey investigated respondents' demographic information, degree of surgical experience, ND technique preferences. Results In our study, 283 out of 1,010 (28%) AHNS surgeon members with a mean age of 50...
January 2017: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/28048906/su-f-t-666-molecular-targeted-gold-nanorods-enhances-the-rbe-of-proton-therapy
#6
A Khoo, N Sahoo, S Krishnan, P Diagaradjane
PURPOSE: In recent years, proton beam radiation therapy (PBRT) has gained significant attention in the treatment of tumors in anatomically complex locations. However, the therapeutic benefit of PBRT is limited by a relative biological effectiveness (RBE) of just 1.1. The purpose of this study is to evaluate whether this limitation can be overcome by artificially enhancing the RBE using molecular-targeted gold nanorods (GNRs). METHODS: Molecular-targeting of GNRs was accomplished using Cetuximab (antibody specific to epidermal growth factor receptor that is over-expressed in tumors) conjugated GNRs (cGNRs) and their binding affinity to Head and Neck cancer cells was confirmed using dark field microscopy and Transmission Electron Microscopy (TEM)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048532/su-f-t-396-impact-of-shoulder-deformation-for-head-and-neck-vmat
#7
Y Uchida, H Tachibana
PURPOSE: For head and neck VMAT (HN-VMAT), variations of position and deformation of patient's shoulders is a concern to affect inaccuracy of dose distribution. It has been reported that the setup error of the shoulders was variable from 5 mm - 1 cm. The beams of the HN-VMAT pass through the shoulders. We assessed the impact of shoulder deformation to dose distribution for HN-VMAT. METHODS: One HN-VMAT plan was generated using a patient's CT. The patient's CT was deformed using ImSimQA (Oncology Systems Limited, Shrewsbury, Shropshire, UK) to generate several patterns of the shoulders' deformations when the right and left humeral heads were shifted with 3, 6, and 15 mm in the superior and inferior directions (SI), 3, 5, and 15 mm in the anterior and posterior directions (AP), and 5 and 15 mm in the right or left direction (LR)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048108/mo-fg-202-05-identifying-treatment-planning-system-errors-in-iroc-h-phantom-irradiations
#8
J Kerns, D Followill, R Howell, A Melancon, F Stingo, S Kry
PURPOSE: Treatment Planning System (TPS) errors can affect large numbers of cancer patients receiving radiation therapy. Using an independent recalculation system, the Imaging and Radiation Oncology Core-Houston (IROC-H) can identify institutions that have not sufficiently modelled their linear accelerators in their TPS model. METHODS: Linear accelerator point measurement data from IROC-H's site visits was aggregated and analyzed from over 30 linear accelerator models...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047904/su-f-t-305-clinical-effects-of-dosimetric-leaf-gap-dlg-values-between-matched-varian-truebeam-tb-linacs
#9
D Mihailidis, J Mallah, D Zhu
PURPOSE: The dosimetric leaf gap (DLG) is an important parameter to be measured for dynamic beam delivery of modern linacs, like the Varian Truebeam (TB). The clinical effects of DLG-values on IMRT and/or VMAT commissioning of two "matched" TB linacs will be presented. METHODS AND MATERIALS: The DLG values on two TB linacs were measured for all energy modalities (filtered and FFF-modes) as part of the dynamic delivery mode commissioning (IMRT and/or VMAT. After the standard beam data was modeled in eclipse treatment planning system (TPS) and validated, IMRT validation was performed based on TG1191 benchmark, IROC Head-Neck (H&N) phantom and sample of clinical cases, all measured on both linacs...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047807/su-d-brb-02-combining-a-commercial-autoplanning-engine-with-database-dose-predictions-to-further-improve-plan-quality
#10
S P Robertson, J A Moore, X Hui, T L DeWeese, P Tran, H Quon, Z Cheng, K Bzdusek, P Kumar, T R McNutt
PURPOSE: Database dose predictions and a commercial autoplanning engine both improve treatment plan quality in different but complimentary ways. The combination of these planning techniques is hypothesized to further improve plan quality. METHODS: Four treatment plans were generated for each of 10 head and neck (HN) and 10 prostate cancer patients, including Plan_A: traditional IMRT optimization using clinically relevant default objectives; Plan_B: traditional IMRT optimization using database dose predictions; Plan_C: autoplanning using default objectives; and Plan_D: autoplanning using database dose predictions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047323/su-f-t-168-development-and-implementation-of-an-anthropomorphic-head-neck-phantom-for-the-assessment-of-proton-therapy-treatment-procedures
#11
D Branco, P Taylor, S Frank, H Li, X Zhang, H Mehrens, M Guindani, D Followill
PURPOSE: To design a Head and Neck (H&N) anthropomorphic QA phantom that the Imaging and Radiation Oncology Core Houston (IROC-H) can use to verify the quality of intensity modulated proton therapy (IMPT) H&N treatments for institutions participating in NCI clinical trials. METHODS: The phantom was created to serve as a remote auditing tool for IROC-H to evaluate an institution's IMPT planning and delivery abilities. The design was based on the composition, size, and geometry of a generalized oropharyngeal tumor and contains critical structures (parotids and spinal cord)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047307/su-f-t-292-imaging-and-radiation-oncology-core-iroc-houston-qa-center-s-anthropomorphic-phantom-program
#12
H Mehrens, B Lewis, C Lujano, T Nguyen, N Hernandez, P Alvarez, A Molineu, D Followill
PURPOSE: To describe the results of IROC Houston's international and domestic end-to-end QA phantom irradiations. METHODS: IROC Houston has anthropomorphic lung, liver, head and neck, prostate, SRS and spine phantoms that are used for credentialing and quality assurance purposes. The phantoms include structures that closely mimic targets and organs at risk and are made from tissue equivalent materials: high impact polystyrene, solid water, cork and acrylic. Motion tables are used to mimic breathing motion for some lung and liver phantoms...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047159/th-cd-207a-10-using-the-gamma-index-to-flag-changes-in-anatomy-during-radiation-therapy-of-head-and-neck-cancer
#13
B Schaly, J Kempe, S Mitchell, V Venkatesan, J Battista
PURPOSE: This article presents a fast algorithm for comparing 3-D anatomy from Cone-Beam CT (CBCT) imaging using the gamma comparison index and to demonstrate how this can be used to flag patients for possible re-planning of treatment. METHODS: CBCT scans acquired on a Varian linear accelerator during treatment were used as input to the gamma comparator using thresholds of 5 mm distance to agreement and 30 Hounsfield Unit CT number difference. The fraction 1 CBCT study was initially used as the reference...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047126/su-d-201-06-remote-dosmetric-auditing-of-vmat-deliveries-for-clinical-trials-using-epid
#14
K Legge, J Lehmann, P Vial, N Miri, P Greer
PURPOSE: To develop a method for remote dosimetric auditing the delivery of VMAT using EPID which allows for simple, inexpensive and time efficient dosimetric credentialing for clinical trials. METHODS: Remote centers are provided with CT datasets and planning guidelines to produce VMAT plans for a head and neck and a post-prostatectomy treatment. Plans are transferred in the planning system to two virtual water equivalent phantoms, one flat and one cylindrical...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046761/mo-g-201-01-a-multi-institutional-study-investigating-the-performance-of-a-knowledge-based-planning-system-against-pinnacle-auto-planning-engine-in-sib-imrt-for-the-head-and-neck-cancer
#15
B Wu, M Kusters, M Kunze-Busch, T Dijkema, T McNutt, G Sanguineti, D Pang
PURPOSE: Knowledge-based Planning (KBP) founded on prior planning experience and Auto-Planning Engine (APE; commercialized in Pinnacle v9.10 TPS) based on progressive optimization algorithm both aim to eliminate the trial-and-error process in radiotherapy inverse planning. This study investigates the performance of the approaches in a multi-institutional setting to evaluate their functionalities in oropharyngeal cancer and offers suggestions how they can be implemented in the clinic. METHODS: Radboud University Medical Center (RUMC) provided 35 oropharyngeal cancer patients (SIB-IMRT with two-dose-level prescription: 68 Gy to PTV68 and 50...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046656/tu-fg-201-06-remote-dosimetric-auditing-for-clinical-trials-using-epid-dosimetry-a-pilot-study
#16
N Miri, J Lehmann, P Vial, K Legge, P Greer
PURPOSE: To perform a pilot study for remote dosimetric credentialing of intensity modulated radiation therapy (IMRT) based clinical trials. The study introduces a novel, time efficient and inexpensive dosimetry audit method for multi-center credentialing. The method employs electronic portal imaging device (EPID) to reconstruct delivered dose inside a virtual flat/cylindrical water phantom. METHODS: Five centers, including different accelerator types and treatment planning systems (TPS), were asked to download two CT data sets of a Head and Neck (H&N) and Postprostatectomy (P-P) patients to produce benchmark plans...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046522/su-c-204-05-magnetic-resonance-induced-adaptive-response-to-orthovoltage-radiation-therapy-in-fsa-and-sa-nh-mouse-tumor-cell-lines
#17
K Mendel, R Miller, J Murley, M Sadinski, D Grdina
PURPOSE: To assess the effect of pre-treatment Magnetic Resonance Imaging (MRI) on cell survival following orthovoltage radiation therapy. METHODS: This in vitro study examined the survival of FSa cells (extracted from methylcholanthrene-induced fibrosarcoma in the flank of a C3H female mouse) and SA-NH cells (derived from a spontaneously arising murine sarcoma tumor) having undergone an MRI scan prior to radiation exposure. Cell cultures were kept at 37 C, in a humidified environment with 5% CO2, and were grown to confluence prior to the start of the experiment...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046339/su-f-p-51-similarity-analysis-of-the-linear-accelerator-machines-based-on-clinical-simulation
#18
K Li
PURPOSE: To evaluate the clinical rationale for Truebeam and Trilogy Linac machines from Varian Medical System as exchangeable treatment modalities in the same radiation oncology department. METHODS: Intensity Modulated Radiotherapy (IMRT) plans for different diseases were selected for this study. These disease sites included brain, head and neck, breast, lung, and prostate. The parameters selected for this study were the energy amount, Monitor Unit (MU); dose coverage of target reflected by prescription isodose volume(PIV); dose spillage described by the volume of 50% isodoseline of the prescription; and dose homogeneities represented by the maximum dose (MaxD) and the minimum dose (MinD) of target volume (TV) and critical structure (CS)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28040660/quality-of-life-and-swallowing-with-standard-chemoradiotherapy-versus-accelerated-radiotherapy-and-panitumumab-in-locoregionally-advanced-carcinoma-of-the-head-and-neck-a-phase-iii-randomised-trial-from-the-canadian-cancer-trials-group-hn-6
#19
Jolie Ringash, John N Waldron, Lillian L Siu, Rosemary Martino, Eric Winquist, Jim R Wright, Abdenour Nabid, John H Hay, Alex Hammond, Khalil Sultanem, Sebastien Hotte, Carson Leong, Ali Abdel Halim El-Gayed, Farah Naz, Kevin Ramchandar, Timothy E Owen, Alexander Montenegro, Brian O'Sullivan, Bingshu E Chen, Wendy R Parulekar
AIM: To compare quality of life (QOL) between standard (SFX) chemoradiotherapy (arm A) and altered fractionation radiotherapy (AFX) with panitumumab (PMab; arm B). METHODS: Patients with T any N + M0 or T3-4N0M0 squamous cell head-neck carcinoma were randomised to SFX (70 Gy/35/7 wks) plus cisplatin (100 mg/m(2) IV × 3) versus AFX (70 Gy/35/6 wks) plus PMab (9 mg/kg IV × 3). QOL was collected at baseline, end of radiation therapy (RT) and 2, 4, 6, 12, 24 and 36 months post-RT using the Functional Assessment of Cancer Therapy Head and Neck (FACT-H&N), MD Anderson Dysphagia Index (MDADI) and SWAL-QOL...
December 29, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/28032679/acr-appropriateness-criteria-%C3%A2-nasal-cavity-and-paranasal-sinus-cancers
#20
Farzan Siddiqui, Richard V Smith, Sue S Yom, Jonathan J Beitler, Paul M Busse, Jay S Cooper, Ehab Y Hanna, Christopher U Jones, Shlomo A Koyfman, Harry Quon, John A Ridge, Nabil F Saba, Francis Worden, Min Yao, Joseph K Salama
The American College of Radiology (ACR) Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive analysis of current medical literature from peer-reviewed journals and the application of well-established methodologies (RAND/UCLA Appropriateness Method and Grading of Recommendations Assessment, Development, and Evaluation or GRADE) to rate the appropriateness of imaging and treatment procedures for specific clinical scenarios...
December 29, 2016: Head & Neck
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