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Head neck oncology

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https://www.readbyqxmd.com/read/29227348/quantitative-pet-ct-in-clinical-practice-assessing-the-agreement-of-pet-tumor-indices-using-different-clinical-reading-platforms
#1
Joyce C Mhlanga, Alin Chirindel, Martin A Lodge, Richard L Wahl, Rathan M Subramaniam
OBJECTIVE: The aim of this study was to determine whether various fluorine-18-fluorodeoxyglucose PET/CT-derived parameters used in oncology vary significantly depending on the interpretation software systems used in clinical practice for multiple human solid tumors. PATIENTS AND METHODS: A total of 120 fluorine-18-fluorodeoxyglucose PET/CT studies carried out in patients with pancreatic, lung, colorectal, and head and neck cancers were evaluated retrospectively on two different vendor software platforms including Mirada and MIMVista...
December 8, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29224827/humidification-mitigates-acute-mucosal-toxicity-during-radiotherapy-when-factoring-volumetric-parameters-trans-tasman-radiation-oncology-group-trog-radiohum-07-03-substudy
#2
A Macann, F Fauzi, J Simpson, G Sasso, H Krawitz, C Fraser-Browne, J Manitz, A Raith
PURPOSE/OBJECTIVE(S): To model in a subset of patients from TROG 07.03 managed at a single site the association between domiciliary based humidification use and mucositis symptom burden during radiotherapy (RT) for head and neck cancer (HNC) when factoring in volumetric radiotherapy parameters derived from tumour and normal tissue regions of interest. MATERIALS/METHODS: From June 2008 through June 2011, 210 patients with HNC receiving RT were randomised to either a control arm or humidification using the Fisher & Paykel Healthcare MR880 humidifier...
December 2017: Oral Oncology
https://www.readbyqxmd.com/read/29209690/prosthetic-rehabilitation-involving-the-use-of-implants-following-a-fibula-free-flap-reconstruction-in-the-treatment-of-osteosarcoma-of-the-maxilla-a-case-report
#3
E Brauner, A Quarato, F De Angelis, G Pompa, S Jamshir, V Valentini, S Di Carlo
INTRODUCTION: Osteosarcoma is an aggressive primary bone tumor composed of connective tissue cells directly producing osteoid and bone. Prosthetic rehabilitations in post-oncological patients after bone reconstruction are not substantially different than those of patients affected by severe atrophy of upper or lower jaw after bone reconstruction. The treatment for patients with a malignant neoplasia of the oral cavity requires multidisciplinary approach by a team of different specialists that follow the patient through the phases of diagnosis, therapy and oral rehabilitation...
November 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/29206328/nutritional-and-hematologic-markers-as-predictors-of-risk-of-surgical-site-infection-in-patients-with-head-and-neck-cancer-undergoing-major-oncologic-surgery
#4
Ho-Jin Son, Jong-Lyel Roh, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
BACKGROUND: Surgical site infection is a complication of surgery for patients with head and neck cancer. We examined the risk factors for surgical site infection in patients undergoing surgery for head and neck cancer. METHODS: The study involved 369 patients who underwent surgery for head and neck cancer. Hematological and nutritional parameters were measured preoperatively and postoperatively. Univariate and multivariate analyses were used to determine the risk factors for surgical site infection...
December 5, 2017: Head & Neck
https://www.readbyqxmd.com/read/29206324/ahns-series-do-you-know-your-guidelines-evidence-based-management-of-oral-cavity-cancers
#5
Amarbir Gill, Nilesh Vasan, Babak Givi, Arjun Joshi
Oral cavity squamous cell carcinoma (OCSCC) is the most common nonmelanoma head and neck cancer in the world, with an estimated 405 000 new cases expected each year. Subsites of the oral cavity include the alveolar ridge, buccal mucosa, anterior tongue, tonsillar pillar, retromolar trigone, hard palate, gingiva, and floor of the mouth. In this issue of the AHNS "Do you know your guidelines?" series, we review the evidence-based approach to the management of oral cavity carcinomas based on the framework provided by the National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology...
December 5, 2017: Head & Neck
https://www.readbyqxmd.com/read/29205995/volume-and-health-outcomes-evidence-from-systematic-reviews-and-from-evaluation-of-italian-hospital-data
#6
Laura Amato, Danilo Fusco, Anna Acampora, Katia Bontempi, Alessandro Cesare Rosa, Paola Colais, Fabio Cruciani, Mariangela D'Ovidio, Francesca Mataloni, Silvia Minozzi, Zuzana Mitrova, Luigi Pinnarelli, Rosella Saulle, Salvatore Soldati, Chiara Sorge, Simona Vecchi, Martina Ventura, Marina Davoli
BACKGROUND Improving quality and effectiveness of healthcare is one of the priorities of health policies. Hospital or physician volume represents a measurable variable with an impact on effectiveness of healthcare. An Italian law calls for the definition of «qualitative, structural, technological, and quantitative standards of hospital care». There is a need for an evaluation of the available scientific evidence in order to identify qualitative, structural, technological, and quantitative standards of hospital care, including the volume of care above or below which the public and private hospitals may be accredited (or not) to provide specific healthcare interventions...
September 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/29204089/subpopulations-of-natural-killer-t-like-cells-before-and-after-surgical-treatment-of-laryngeal-cancer
#7
Janusz Klatka, Ewelina Grywalska, Anna Hymos, Ewelina Krasowska, Michał Mielnik, Dorota Siwicka-Gieroba, Justyna Markowicz, Piotr Trojanowski, Witold Olszański, Jacek Roliński
Introduction: Tumours connected with head and neck comprise about 5% of all tumours. The most frequent histological type of laryngeal carcinoma is squamous cell carcinoma. Different research projects suggest that the role of T lymphocytes might be significant in tumour development. iNKT cells are a new subpopulation of T cells and show cytotoxic activity against tumours. iNKT cells participate in modulating the function of other cells which have anti-tumour properties and secrete cytokines, which have pro-inflammatory and anti-inflammatory effects...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29199656/retrospective-analysis-of-palliative-metronomic-chemotherapy-in-head-and-neck-cancer
#8
V M Patil, V Noronha, A Joshi, L Nayak, N Pande, A Chandrashekharan, S Dhumal, A Bhattacharjee, S Banavali, K Prabhash
BACKGROUND: Metronomic chemotherapy has shown promising results in selected patients of head and neck cancer in a small randomized study. This retrospective analysis was done to see whether the efficacy of metronomic chemotherapy in an unselected cohort of head and neck cancer patients is similar to that reported in the randomized study and the influence of the site and subsite of head and neck cancer on survival. MATERIALS AND METHODS: This was a retrospective analysis of head and neck cancer patients who received palliative metronomic chemotherapy between January 2013 and February 2015...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29199655/comparison-of-paclitaxel-cetuximab-chemotherapy-versus-metronomic-chemotherapy-consisting-of-methotrexate-and-celecoxib-as-palliative-chemotherapy-in-head-and-neck-cancers
#9
V M Patil, V Noronha, A Joshi, V Agarwala, V Muddu, A Ramaswamy, A Chandrasekharan, S Dhumal, S Juvekar, A Arya, A Bhattacharjee, K Prabhash
BACKGROUND: The present match pair analysis was planned to compare the efficacy of cetuximab-paclitaxel-based chemotherapy versus metronomic therapy. MATERIALS AND METHODS: Sixty patients with metastatic/recurrent head and neck squamous cell cancer treated with weekly paclitaxel (80 mg/m2) and cetuximab were matched with sixty patients treated with oral metronomic chemotherapy consisting of methotrexate and celecoxib. The progression-free survival (PFS) and overall survival (OS) between the cohorts were compared using log-rank test...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29196905/oncology-curricula-in-postgraduate-general-dentistry-programs-a-survey-of-residency-program-directors
#10
Evan B Rosen, Alexander Drew, Joseph M Huryn
Management of patients undergoing treatment for cancer requires a multidisciplinary team including general dentistry providers; however, the relative knowledge and training of general dentists in the management of this patient population are relatively unknown. The purpose of this study was to assess the oncology curricula of postgraduate general dentistry training programs, from the perspective of the program directors, to better understand the opportunities for and/or barriers to dental care for cancer patients...
December 1, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29192505/us-oncology-wide-incidence-duration-costs-and-deaths-from-chemoradiation-mucositis-and-antimucositis-therapy-benefits
#11
Ricky W McCullough
Approximate oncology-wide incidence, duration, costs and deaths associated with mucositis and identify health economic benefits of antimucositis therapies. Review the literature relevant to the clinical experience of mucositis by pathophysiology, incidence, duration, costs and deaths. Use US insurance actuarial and epidemiology on cancer to generalize an oncology-wide impact of toxic mucositis. Toxic mucositis causes oropharyngoesophageal ulcerations, chemo-induced nausea, vomiting and diarrhea. Acutely, it lasts 102 days/six cycles of chemotherapy, 60 days in human stem-cell transplantation patients and 70-84 days in head and neck cancer patients at annual costs of US$13...
December 1, 2017: Future Oncology
https://www.readbyqxmd.com/read/29192315/clinical-factors-associated-with-reoperation-and-prolonged-length-of-stay-in-free-tissue-transfer-to-oncologic-head-and-neck-defects
#12
William W Thomas, Jason Brant, Jinbo Chen, Orly Coblens, John P Fischer, Jason G Newman, Ara A Chalian, Rabie M Shanti, Steven B Cannady
Importance: Prolonged hospitalization and reoperation after free tissue transfer may be associated with certain clinical factors. Objective: To determine patient and surgical factors associated with length of stay (LOS) and reoperation following surgical procedures for malignant neoplasm of the head and neck involving microvascular free tissue transfer reconstruction. Design, Setting, and Participants: This was a retrospective review of American College of Surgeons National Surgical Quality Improvement Program data from 2012 to 2014 using International Classification of Diseases, Ninth Revision (ICD-9), codes for malignant neoplasms of the head and neck...
November 30, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/29185392/immunotherapy-in-head-and-neck-cancer-evidence-and-perspectives
#13
Alicia Tosoni, Enrico Franceschi, Ernesto Pasquini, Andrea Lanese, Elisa Donini, Maria Pia Foschini, Danilo Dall'Olio, Alba A Brandes
Head and neck squamous cell carcinomas evade immune response through multiple immunologic resistance mechanisms. Two of the most commonly involved checkpoint inhibitory mechanisms are CTLA-4 and PD-1/PD-L1, which act at earlier and later stages of immune response to tumors. Pembrolizumab and nivolumab are PD-1 antibodies that interrupt the immunosuppressive pathway of inhibitory checkpoints, which are used by tumor cells to prevent immune reaction. Both recently gained US FDA approval for the treatment of patients with recurrent or metastatic head and neck cancer with disease progression during or following platinum containing chemotherapy...
December 2017: Immunotherapy
https://www.readbyqxmd.com/read/29180076/delineation-of-the-primary-tumour-clinical-target-volumes-ctv-p-in-laryngeal-hypopharyngeal-oropharyngeal-and-oral-cavity-squamous-cell-carcinoma-airo-caca-dahanca-eortc-georcc-gortec-hknpcsg-hncig-iag-kht-lprhht-ncic-ctg-ncri-nrg-oncology-phns-sbrt-somera
#14
Vincent Grégoire, Mererid Evans, Quynh-Thu Le, Jean Bourhis, Volker Budach, Amy Chen, Abraham Eisbruch, Mei Feng, Jordi Giralt, Tejpal Gupta, Marc Hamoir, Juliana K Helito, Chaosu Hu, Keith Hunter, Jorgen Johansen, Johannes Kaanders, Sarbani Ghosh Laskar, Anne Lee, Philippe Maingon, Antti Mäkitie, Francesco Micciche', Piero Nicolai, Brian O'Sullivan, Adela Poitevin, Sandro Porceddu, Krzysztof Składowski, Silke Tribius, John Waldron, Joseph Wee, Min Yao, Sue S Yom, Frank Zimmermann, Cai Grau
PURPOSE: Few studies have reported large inter-observer variations in target volume selection and delineation in patients treated with radiotherapy for head and neck squamous cell carcinoma. Consensus guidelines have been published for the neck nodes (see Grégoire et al., 2003, 2014), but such recommendations are lacking for primary tumour delineation. For the latter, two main schools of thoughts are prevailing, one based on geometric expansion of the Gross Tumour Volume (GTV) as promoted by DAHANCA, and the other one based on anatomical expansion of the GTV using compartmentalization of head and neck anatomy...
November 24, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29178364/fine-needle-aspiration-cytology-for-parotid-lesions-can-we-avoid-surgery
#15
Yotam Shkedy, Uri Alkan, Aviram Mizrahi, Tzippy Shochat, Orr Dimitstein, Sara Morgenstern, Thomas Shpitzer, Gideon Bachar
OBJECTIVE: Salivary gland neoplasms are rare tumors, with most arising in the parotid gland. Fine-needle aspiration cytology (FNAC) is a common method for pre-operative evaluation of parotid masses, although its usefulness is controversial. This study was designed to evaluate the accuracy of FNAC in a large cohort of patients, with emphasis on diagnosis of benign tumors and especially Warthin tumor which can be managed conservatively. STUDY DESIGN: Retrospective case series with chart review...
November 27, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29174070/acs-nsqip-risk-calculator-reliability-in-head-and-neck-oncology-the-effect-of-prior-chemoradiation-on-nsqip-risk-estimates-following-laryngectomy
#16
Angela Cao, Sarah Khayat, Elizabeth Cash, Christopher Nickel, John Gettelfinger, Paul Tennant, Jeffrey Bumpous
PURPOSE: To determine whether inclusion of chemoradiation history increases estimated risk for complications following total laryngectomy using the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) Surgical Risk Calculator. MATERIALS AND METHODS: A retrospective review of 96 patients with laryngeal cancer, approximately half of who had received prior chemoradiation, who underwent laryngectomy between January 2010 and December 2014...
November 13, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29173757/head-and-neck-cancer-survivorship-learning-the-needs-meeting-the-needs
#17
REVIEW
Jolie Ringash, Lori J Bernstein, Gerald Devins, Colleen Dunphy, Meredith Giuliani, Rosemary Martino, Sara McEwen
Cancers of the head and neck and the treatments required to control them frequently result in serious and persistent impairments that can affect participation and quality of life. Increased recognition of the needs of cancer survivors and their caregivers has prompted research focused on the unique concerns of this complex group. Unmet needs have been identified among 60-70% of patients and a similar proportion of their partners; impacts can include profound social effects, isolation, and psychiatric conditions...
January 2018: Seminars in Radiation Oncology
https://www.readbyqxmd.com/read/29173751/the-current-state-of-biological-and-clinical-implications-of-human-papillomavirus-related-oropharyngeal-cancer
#18
REVIEW
Shao Hui Huang, Brian O'Sullivan, John Waldron
In the effort to control human papillomavirus-related oropharyngeal cancer, the head and neck oncology community has devoted much effort to understanding its disease biology and clinical behavior, and refining strategies to address early diagnosis and optimal management for the affected population. This review identifies articles published up to March 2017 on tumor biology and clinical implications of human papillomavirus-related oropharyngeal cancer, and summarizes the findings in some key areas. These include potential screening strategies, possible anatomical features responsible for early lymph node involvement and its implication for staging, biological mechanisms to explain superior outcomes compared to traditional nonviral-related mucosal cancers, re-appreciation of traditional prognostic factors (eg, hypoxia, extranodal extension, and smoking), and current efforts to optimize management for this patient population...
January 2018: Seminars in Radiation Oncology
https://www.readbyqxmd.com/read/29172863/use-of-larynx-preservation-strategies-in-the-treatment-of-laryngeal-cancer-american-society-of-clinical-oncology-clinical-practice-guideline-update
#19
Arlene A Forastiere, Nofisat Ismaila, Jan S Lewin, Cherie Ann Nathan, David J Adelstein, Avraham Eisbruch, Gail Fass, Susan G Fisher, Scott A Laurie, Quynh-Thu Le, Bernard O'Malley, William M Mendenhall, Snehal Patel, David G Pfister, Anthony F Provenzano, Randy Weber, Gregory S Weinstein, Gregory T Wolf
Purpose To update the guideline recommendations on the use of larynx-preservation strategies in the treatment of laryngeal cancer. Methods An Expert Panel updated the systematic review of the literature for the period from January 2005 to May 2017. Results The panel confirmed that the use of a larynx-preservation approach for appropriately selected patients does not compromise survival. No larynx-preservation approach offered a survival advantage compared with total laryngectomy and adjuvant therapy as indicated...
November 27, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29172282/primary-locations-of-malignant-melanoma-lesions-depending-on-patients%C3%A2-gender-and-age
#20
Karolina Stanienda-Sokół, Natalia Salwowska, Martyna Sławińska, Katarzyna Wicherska-Pawłowska, Anna Lorenc, Dominika Wcisło-Dziadecka, Jerzy Wydmański, Wojciech Majewski
Introduction: Location of malignant melanoma lesions depends on environmental, genetic, sociological and demographical factors. Available sources do not provide enough information on such dependencies in various populations. There is no data concerning the role of socio-demographic factors for the population of the Central and Eastern Europe. Aim: The aim of this work was to evaluate the anatomical location of the primary malignant melanoma lesion in correlation to patients’ gender and age. Material and methods: A retrospective analysis of medical documentation of 363 patients has been performed...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
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