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Head neck oncology

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https://www.readbyqxmd.com/read/29893275/evaluation-of-xrcc1-gene-polymorphism-as-a-biomarker-in-head-and-neck-cancer-patients-undergoing-chemoradiation-therapy
#1
Sambit Swarup Nanda, Ajeet Kumar Gandhi, Madhup Rastogi, Rohini Khurana, Rahat Hadi, Kamal Sahni, Surendra Prasad Mishra, Anoop K Srivastava, Madan Lal Brahma Bhatt, Devendra Parmar
PURPOSE: We evaluated the correlation of the x-ray repair cross complementing gene 1 (XRCC1) Arg194Trp polymorphism with clinical outcomes in head and neck squamous cell carcinoma (HNSCC) patients treated with concurrent chemoradiation therapy (CCRT). METHODS AND MATERIALS: In this prospective cohort study, we included 101 patients with HNSCC (oral cavity, pharynx, and larynx) who were aged ≥ 18 years, had stage III to IVB disease, had a Karnofsky Performance Status ≥ 80, and were deemed fit for CCRT...
July 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29887687/acsnsqip-risk-calculator-in-indian-patients-undergoing-surgery-for-head-and-neck-cancers-is-it-valid
#2
Narayana Subramaniam, Deepak Balasubramanian, Pradeep Rka, Samskruthi Murthy, Priyank Rathod, Sivakumar Vidhyadharan, Krishnakumar Thankappan, Subramania Iyer
Pre-operative assessment is vital to determine patient-specific risks and minimize them in order to optimize surgical outcomes. The American College of Surgeons National Surgical Quality Improvement Program (ACSNSQIP) Surgical Risk Calculator is the most comprehensive surgical risk assessment tool available. We performed this study to determine the validity of ACSNSQIP calculator when used to predict surgical complications in a cohort of patients with head and neck cancer treated in an Indian tertiary care center...
June 2018: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29887186/head-and-neck-squamous-cell-carcinoma-in-people-living-with-hiv-in-france
#3
A Picard, L Arowas, L Piroth, I Heard, T Ferry
OBJECTIVES: Head and neck squamous cell carcinoma (HNSCC), mainly due to smoking, is one of the leading causes of cancer deaths. However, an increasing number of tumors - especially oropharyngeal cancer - are reported in non-smokers in association with the human papillomavirus (HPV). As HIV-infected individuals are particularly at risk of HPV-related disease, we aimed to describe the burden of HNSCC in this population. METHODS: Retrospective chart review of patients from HIV clinics diagnosed with HNSCC between 2004 and 2014...
June 7, 2018: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29884410/multi-modality-3d-mandibular-resection-planning-in-head-and-neck-cancer-using-ct-and-mri-data-fusion-a-clinical-series
#4
J Kraeima, B Dorgelo, H A Gulbitti, R J H M Steenbakkers, K P Schepman, J L N Roodenburg, F K L Spijkervet, R H Schepers, M J H Witjes
OBJECTIVES: 3D virtual surgical planning (VSP) and guided surgery has been proven to be an effective tool for resection and reconstruction of the mandible. Currently, most widely used 3D VSP approaches to mandibular resection do not include detailed tumour information in the VSP. This manuscript presents a strategy where the aim was to incorporate tumour visualisation into the 3D virtual plan. Three-dimensional VSP of the mandibular resections was based on the fusion of CT and MRI data which was subsequently applied in clinical practice...
June 2018: Oral Oncology
https://www.readbyqxmd.com/read/29884312/survival-of-dental-implants-placed-in-vascularised-fibula-free-flaps-after-jaw-reconstruction
#5
Sameh Attia, Joerg Wiltfang, Jörn Pons-Kühnemann, Jan-Falco Wilbrand, Philipp Streckbein, Christopher Kähling, Hans-Peter Howaldt, Heidrun Schaaf
PURPOSE: Ablative oncological surgery to treat head-and-neck cancer often triggers a requirement for jaw reconstruction. Modern surgical procedures using free microvascular flaps afford acceptable outcomes in terms of restoration of bony and soft tissue defects. A fibula free flap is often the preferred flap, as the bone length is considerable and a two-surgeon approach is possible. Dental implants play important roles in functional rehabilitation. Our aim was to evaluate the survival of dental implants placed in reconstructed areas after transfer of fibula tissue to the jaw...
June 5, 2018: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29879257/naturopathic-self-treatment-of-an-atypical-fibroxanthoma-lessons-for-dermatologic-surgery
#6
Brandon Worley, Andrew J Nemechek, Samantha Stoler, Joel L Cohen
BACKGROUND: Alternative therapies are favored by some patients. In skin cancer, this may be to try to avoid surgery out of fear for the procedure and its functional or cosmetic consequences. Frequently, use of these therapies is not curative and can cause harm. Our objective is to detail a case where black salve was used as a natural remedy for an atypical fibroxanthoma and resulted in a severe burn. We highlight the challenges of communicating effective treatment options for those who have strong beliefs concerning natural remedies after a cancer diagnosis...
June 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29872643/three-dimensional-map-of-isoprognostic-zones-in-glottic-cancer-treated-by-transoral-laser-microsurgery-as-a-unimodal-treatment-strategy
#7
Cesare Piazza, Marta Filauro, Alberto Paderno, Filippo Marchi, Pietro Perotti, Riccardo Morello, Stefano Taboni, Giampiero Parrinello, Fabiola Incandela, Andrea Iandelli, Francesco Missale, Giorgio Peretti
Introduction: The Union for International Cancer Control-American Joint Committee on Cancer TNM staging system for glottic squamous cell carcinoma (SCC) includes different types of lesions defined by the involvement of specific subsites in each T category. Our study aims to identify different subcategories according to tumor local extension and determine oncologic outcomes after treatment by transoral laser microsurgery (TLM) alone. Methods: We retrospectively evaluated 410 patients affected by previously untreated pT1-pT3 glottic SCC treated by TLM alone from January 2005 to December 2015 at the Departments of Otorhinolaryngology-Head and Neck Surgery, Universities of Genoa and Brescia, Italy...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29870283/use-of-inpatient-palliative-care-by-type-of-malignancy
#8
Jessica M Ruck, Joseph K Canner, Thomas J Smith, Fabian M Johnston
BACKGROUND: Although mounting evidence supports the use of palliative care (PC) to improve care experiences and quality of life for oncology patients, the frequency of and factors associated with PC use during oncology-related hospitalizations remain unknown. MATERIALS AND METHODS: Using the National Inpatient Sample dataset, hospitalizations during 2012-2014 for a primary diagnosis of cancer with high risk of in-hospital mortality were identified. PC use was identified using the V66...
June 5, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29869513/-the-relationship-between-cervicovaginal-and-oral-hpv-infection
#9
M Nipčová, J Sláma, T Podlešák, H Neumannová, M Zikán, B Sehnal
OBJECTIVE: To summarize current knowledge of the relationship of genital and oral HPV infection in women. DESIGN: Review article. SETTING: Gynecologic Oncology Center, Department of Gynecology and Obstetrics, Hospital Na Bulovce and 1st Medical School of Charles University, Prague; Gynecologic Oncology Center, Department of Gynecology and Obstetrics, General Faculty Hospital and 1st Medical School of Charles University, Prague; ENT Department, Hospital Na Bulovce, Prague...
2018: Ceská Gynekologie
https://www.readbyqxmd.com/read/29868479/transoral-laser-microsurgery-for-supraglottic-cancer
#10
Petra Ambrosch, Mireia Gonzalez-Donate, Asita Fazel, Claudia Schmalz, Jürgen Hedderich
Introduction: Transoral laser microsurgery (TLM) is an accepted and effective treatment strategy for supraglottic carcinomas. Early supraglottic carcinoma has excellent outcomes independently of the treatment approach. The role of TLM for the treatment of locally advanced tumors is debated. Particularly, the functional outcomes after TLM have to be proven by functional assessment of large cohorts of patients. This study analyzes the oncologic and functional outcomes after TLM for supraglottic carcinomas...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29868164/oral-shedding-of-human-herpesviruses-in-patients-undergoing-radiotherapy-chemotherapy-for-head-and-neck-squamous-cell-carcinoma-is-not-affected-by-xerostomia
#11
Michelle Palmieri, Mariana Ornaghi, Victor Adriano de Oliveira Martins, Luciana Correa, Thais Bianca Brandao, Ana Carolina do Prado Ribeiro, Laura Masami Sumita, Tania Regina Tozetto-Mendoza, Claudio Sergio Pannuti, Paulo Henrique Braz-Silva
Background : Xerostomia is a very relevant and frequent complication of radiotherapy, causing the irradiated oral mucosa to be affected by bacterial, fungal and viral infections. Objective : The objective of this study was to evaluate a possible relationship between oral shedding of human herpesviruses and xerostomia in patients with squamous cell carcinoma of head and neck submitted to radio/chemotherapy. Methods : In this study, oral rinse samples were collected weekly from 20 patients during radiotherapy...
2018: Journal of Oral Microbiology
https://www.readbyqxmd.com/read/29865939/prevalence-and-risk-factors-of-suicidal-ideation-among-patients-with-head-and-neck-cancer-longitudinal-study
#12
Melissa Henry, Zeev Rosberger, Lia Bertrand, Christina Klassen, Michael Hier, Anthony Zeitouni, Karen Kost, Alex Mlynarek, Keith Richardson, Martin Black, Christina MacDonald, Xun Zhang, Gabrielle Chartier, Saul Frenkiel
Objectives (1) Determine 1-year period prevalence of suicidal ideation, suicide attempt, and completed suicide among patients newly diagnosed with a first occurrence of head and neck cancer (HNC). (2) Characterize stability and trajectory of suicidal ideation over the year following cancer diagnosis. (3) Identify patients at risk of suicidal ideation. Study Design Prospective longitudinal study with 1-year follow-up. Setting Three university-affiliated outpatient departments of otolaryngology-head and neck surgery...
May 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29798945/radical-radiotherapy-for-carcinoma-of-the-larynx-in-the-elderly-functional-and-oncological-outcomes-from-a-tertiary-cancer-care-center-in-india
#13
Narayana R Subramaniam, Vijay Kumar Srinivasalu, Deepak Balasubramanian, K U Pushpaja, Anoop Remesan Nair, Chelakkot Prameela, Krishnakumar Thankappan, Subramania Iyer
INTRODUCTION: It is estimated that around 10% of all head and neck cancer patients in India are aged over 70 years. Elderly patients are often subjected to palliative or inadequate treatment for head and neck cancers in spite of being candidates for curative intent therapy. In this study we evaluated our use of radical radiotherapy in carcinoma larynx for patients over seventy years of age to determine morbidity, likelihood of completing therapy, functional and oncological outcomes. MATERIALS AND METHODS: 132 patients of squamous cell carcinoma of the larynx treated between 2005-2015 at Amrita Institute of Medical Sciences, Kochi who were seventy years of age or older were included...
July 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29797030/factors-predicting-intolerance-to-definitive-conventional-radiotherapy-in-geriatric-patients
#14
Chai Hong Rim, Won Sup Yoon, Jung Ae Lee, Dae Sik Yang, Nam Kwon Lee, Young Je Park, Chul Yong Kim
PURPOSE: Although radiotherapy can be administered with a relatively low therapeutic burden, many elderly patients do not complete radiotherapy. In order to predict intolerance during radiotherapy, this study retrospectively analyzed the frequency of and risk factors for radiotherapy interruption among geriatric patients. METHODS: From September 2009 to December 2016, 353 patients aged ≥70 years received definitive radiotherapy with a conventionally fractionated schedule...
May 24, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29796159/analysis-of-kit-gene-mutations-in-patients-with-melanoma-of-the-head-and-neck-mucosa-a-retrospective-clinical-report
#15
Ullyanov Bezerra Toscano de Mendonça, Claudio Roberto Cernea, Leandro Luongo Matos, Roberto Rego Monteiro de Araujo Lima
Unlike their cutaneous counterparts, head and neck mucosal malignant melanomas (HNMM) are more aggressive, and their prognostic markers have not been fully elucidated. This study, comprising 28 patients with HNMM, aimed to establish the relationship between different mutations and outcome, define the incidence of KIT mutations in HNMM, and identify the correlation among therapeutic options, histopathological findings, demographic data, and clinical response. Clinical analysis included patient characteristics, staging, primary and palliative treatments, and disease-free survival and overall survival (OS)...
May 1, 2018: Oncotarget
https://www.readbyqxmd.com/read/29794758/comparison-of-standard-dose-3-weekly-cisplatin-and-low-dose-weekly-cisplatin-for-concurrent-chemoradiation-of-patients-with-locally-advanced-head-and-neck-squamous-cell-cancer-a-multicenter-retrospective-analysis
#16
So Yeon Lee, Yoon Seok Choi, Ik-Chan Song, Sang Gon Park, Bhumsuk Keam, Young Jun Yang, Eun-Kee Song, Hyo Jin Lee, Sang-Hee Cho, Hyeok Shim, Keon Uk Park, Ki-Hyeong Lee, Deog-Yeon Jo, Ihn-Seong Jo, Hwan-Jung Yun
Standard treatment for locally advanced (stage III-IV) head and neck squamous cell cancer (LA-HNSCC) is concurrent chemoradiation therapy (CCRT) with cisplatin 100 mg/m every 3 weeks. For medically unfit patients susceptible to treatment-related adverse events, low-dose weekly cisplatin (30-40 mg/m) can be used as an alternative. In this study, we retrospectively compared the therapeutic outcomes of low-dose weekly cisplatin regimen and standard regimen in CCRT for LA-HNSCC.The medical records of histologically confirmed LA-HNSCC patients were retrospectively reviewed from January 1, 2007 to December 31, 2012...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29790687/expression-profiles-of-selected-genes-in-tumors-and-matched-surgical-margins-in-oral-cavity-cancer-do-we-have-to-pay-attention-to-the-molecular-analysis-of-the-surgical-margins
#17
Joanna K Strzelczyk, Łukasz Krakowczyk, Karolina Gołąbek, Aleksander J Owczarek
BACKGROUND: Head and neck squamous cell carcinomas (HNSCCs) are associated with an interplay between genetics and the environment; they account for 3% of all diagnosed malignant tumors in men and 2% of those in women. OBJECTIVES: The aim of the study was to analyze the significance of TIMP3, SFRP1, SFRP2, CDH1, RASSF1, RORA, and DAPK1 gene expression in head and neck squamous cell carcinoma tumors, and in matching surgical margin samples. We also analyzed the association between clinical parameters and the expression of the selected genes...
April 24, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29789760/high-dose-rate-brachytherapy-in-treatment-of-non-melanoma-skin-cancer-of-head-and-neck-region-preliminary-results-of-a-prospective-single-institution-study
#18
Bita Kalaghchi, Ebrahim Esmati, Reza Ghalehtaki, Marzieh Gomar, Ramin Jaberi, Soraya Gholami, Somayyeh Babaloui, Mansoureh Nabavi, Sarvazad Sotoudeh, Nezhat Khanjani, Ali Kazemian, Farnaz Amouzegar-Hashemi, Mahdi Aghili, Marzieh Lashkari
Purpose: Skin cancers are the most common human malignancy with increasing incidence. Currently, surgery is standard of care treatment for non-melanoma skin cancers. However, brachytherapy is a growing modality in the management of skin cancers. Therefore, we aimed to assess the outcome of patients with non-melanoma skin cancers treated by high-dose-rate (HDR) brachytherapy with surface mold technique. Material and methods: In this prospective study, we recruited patients with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of the skin who were candidates for definitive or adjuvant brachytherapy during 2013-2014...
April 2018: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29789167/prevalence-of-malnutrition-and-impact-on-clinical-outcomes-in-cancer-services-a-comparison-of-two-time-points
#19
Kathryn M Marshall, Jenelle Loeliger, Linda Nolte, Amber Kelaart, Nicole K Kiss
BACKGROUND: The prevention and management of malnutrition is increasingly recognised as a significant element of cancer care. By identifying and comparing cancer malnutrition in two large cross-sectional cancer populations, this study aims to provide a greater understanding of clinical characteristics and trajectories relating to cancer malnutrition. METHODS: A multi-centre point prevalence study was conducted in Victoria, Australia at two time points (March 2012, May 2014)...
May 2, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29784145/the-effect-of-the-use-of-thyme-honey-in-minimizing-radiation-induced-oral-mucositis-in-head-and-neck-cancer-patients-a-randomized-controlled-trial
#20
Melanie Charalambous, Vasilios Raftopoulos, Lefkios Paikousis, Nicos Katodritis, Ekaterini Lambrinou, Dimitrios Vomvas, Morpho Georgiou, Andreas Charalambous
PURPOSE: Radiation-induced oral mucositis is one of the main side effects during and after the treatment of head and neck cancer patients. The study was designed to provide evidence on the effectiveness of thyme honey on oral mucositis management. METHODS: This was a randomised controlled trial (RCT) with 72 head and neck cancer patients who were divided either to the intervention group (thyme honey rinses) or to the control group (saline rinses). Oral mucositis was assessed according to the Radiation Therapy Oncology Group (RTOC criteria), and assessments were performed weekly starting at the 4th week of the radiotherapy for seven weeks and repeated once 6 months later...
June 2018: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
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