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Hippocampus radiotherapy

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https://www.readbyqxmd.com/read/29463267/hippocampus-sparing-radiotherapy-using-volumetric-modulated-arc-therapy-vmat-to-the-primary-brain-tumor-the-result-of-dosimetric-study-and-neurocognitive-function-assessment
#1
Kyung Su Kim, Chan Woo Wee, Jin-Yong Seok, Joo Wan Hong, Jin-Beom Chung, Keun-Yong Eom, Jae-Sung Kim, Chae-Yong Kim, Young Ho Park, Yu Jung Kim, In Ah Kim
BACKGROUND: We hypothesized that hippocampal-sparing radiotherapy via volumetric modulated arc therapy (VMAT) could preserve the neurocognitive function (NCF) of patients with primary brain tumors treated with radiotherapy. METHODS: We reviewed data from patients with primary brain tumors who underwent hippocampal-sparing brain radiotherapy via VMAT between February 2014 and December 2015. The optimization criteria for the contralateral hippocampus was a maximum dose (Dmax ) of less than 17 Gy...
February 20, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29424258/anti-leukemic-treatment-induced-neurotoxicity-in-long-term-survivors-of-childhood-acute-lymphoblastic-leukemia-impact-of-reduced-central-nervous-system-radiotherapy-and-intermediate-to-high-dose-methotrexate
#2
Olga Zając-Spychała, Mikolaj Pawlak, Katarzyna Karmelita-Katulska, Jakub Pilarczyk, Katarzyna Jończyk-Potoczna, Agnieszka Przepióra, Katarzyna Derwich, Jacek Wachowiak
The aim of the study was to evaluate the long-term neurodevelopmental consequences of currently applied acute lymphoblastic leukemia (ALL) therapy containing chemotherapy alone or combined with 12 Gy radiotherapy. Seventy-nine children aged 6.3-21.7 years diagnosed with ALL and treated according to ALL IC-BFM 2002 have been studied. The control group consisted of 23 children newly diagnosed with ALL. We assessed subcortical gray matter volume using automatic MRI segmentation and cognitive performance to identify differences between three therapeutic schemes and patients prior to treatment...
February 9, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29390424/adult-hippocampal-ganglioneuroblastoma-case-report-and-literature-review
#3
Pei-Sen Yao, Guo-Rong Chen, Huang-Cheng Shang-Guan, Qing-Song Lin, Xing-Fu Wang, Shu-Fa Zheng, De-Zhi Kang
RATIONALE: Intracranial ganglioneuroblastoma represents a rare subtype of primitive neuroectodermal tumor. Here, we report a hippocampal ganglioneuroblastoma and a literature review of cerebral anglioneuroblastoma is carried out. PATIENT CONCERNS: We report a 16-year-old male patient presenting with absence seizure and high-infiltration hippocampal ganglioneuroblastoma. INTERVENTIONS: Magnetic resonance imaging (MRI) indicates a space-occupying lesion with a well-defined margin in the right temporal lobe and hippocampus...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29372691/prediction-of-radiation-necrosis-in-a-rodent-model-using-magnetic-resonance-imaging-apparent-transverse-relaxation-formula-see-text
#4
Jean-Guy Belliveau, Michael D Jensen, James M P Stewart, Igor Solovey, L Martyn Klassen, Glenn S Bauman, Ravi S Menon
BACKGROUND AND PURPOSE: Radiation necrosis remains an irreversible long-term side-effect following radiotherapy to the brain. The ability to predict areas that could ultimately develop into necrosis could lead to prevention and management of radiation necrosis. MATERIALS AND METHODS: Fischer 344 rats were irradiated using two platforms (micro-CT irradiator and x-Rad 225 IGRT) with radiation up to 30 Gy for the micro-CT and 40 Gy for the xRAD-224 to half the brain...
January 26, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29351056/remediation-of-radiation-induced-cognitive-dysfunction-through-oral-administration-of-the-neuroprotective-compound-nsi-189
#5
Barrett Allen, Munjal M Acharya, Celine Lu, Erich Giedzinski, Nicole Chmielewski, David Quach, Mike Hefferan, Karl K Johe, Charles L Limoli
Clinical management of primary and secondary central nervous system (CNS) malignancies frequently includes radiotherapy to forestall tumor growth and recurrence after surgical resection. While cranial radiotherapy remains beneficial, adult and pediatric brain tumor survivors suffer from a wide range of debilitating and progressive cognitive deficits. Although this has been recognized as a significant problem for decades, there remains no clinical recourse for the unintended neurocognitive sequelae associated with these types of cancer treatments...
January 19, 2018: Radiation Research
https://www.readbyqxmd.com/read/29344836/boost-irradiation-integrated-to-whole-brain-radiotherapy-in-the-management-of-brain-metastases
#6
Ágnes Dobi, Emese Fodor, Anikó Maráz, Zsófia Együd, Adrienne Cserháti, László Tiszlavicz, Zita Reisz, Pál Barzó, Zoltán Varga, Katalin Hideghéty
Our retrospective analysis aimed to evaluate the clinical value of dose intensification schemes: WBRT and consecutive, delayed, or simultaneous integrated boost (SIB) in brain metastasis (BM) management. Clinical data and overall survival (OS) of 468 patients with BM from various primaries treated with 10 × 3 Gy WBRT (n = 195), WBRT+ 10 × 2 Gy boost (n = 125), or simultaneously 15 × 2.2 Gy WBRT+0.7 Gy boost (n = 148) during a 6-year period were statistically analysed. Significant difference in OS could be detected with additional boost to WBRT (3...
January 17, 2018: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29332467/is-hippocampal-avoidance-during-whole-brain-radiotherapy-risky-for-patients-with-small-cell-lung-cancer-hippocampal-metastasis-rate-and-associated-risk-factors
#7
Esra Korkmaz Kirakli, Ozgur Oztekin
OBJECTIVES: Hippocampal avoidance during whole-brain radiotherapy is performed to prevent neural stem cell injury causing neurocognitive dysfunction. Nevertheless, the estimated risk of metastases in hippocampal avoidance area in small-cell lung cancer is unknown. The current study aimed to characterize the metastatic distribution within the brain relative to the hippocampus, estimate the incidence of hippocampal metastasis in patients with small-cell lung cancer, and identify clinical and radiographic variables that may be associated with the risk of hippocampal avoidance area metastasis...
December 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29219117/prediction-of-radiation-necrosis-in-a-rodent-model-using-magnetic-resonance-imaging-apparent-transverse-relaxation-r-sub-2-sub-sup-sup
#8
Jean-Guy Belliveau, Michael D Jensen, James M P Stewart, Igor Solovey, Martyn L Klassen, Glenn S Bauman, Ravi S Menon
Radiation necrosis remains an irreversible long-term side-effect following radiotherapy to the brain. The ability to predict areas that could ultimately develop into necrosis could lead to prevention and management of radiation necrosis. Materials and Methods: Fischer 344 rats were irradiated using two platforms (micro-CT irradiator and x-RAD 225 IGRT) with radiation up to 30 Gy for the micro-CT and 40 Gy for the xRAD-224 to half the brain. Animals were subsequently imaged using a 9.4T MRI scanner every 2-4 weeks for up to 28 weeks using a 7-echo gradient echo sequence...
December 8, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29125239/hippocampal-sparing-approach-in-fractionated-stereotactic-brain-vmat-radio-therapy-a-retrospective-feasibility-analysis
#9
Maria Daniela Falco, Stefano Giancaterino, Marco D'Andrea, Ramon Gimenez De Lorenzo, Marianna Trignani, Luciana Caravatta, Clelia Di Carlo, Saide Di Biase, Albina Allajbej, Domenico Genovesi
Volumetric Modulated Arc Therapy (VMAT) techniques for fractioned stereotactic brain radiotherapy (FSBRT) can achieve highly conformal dose distribution to intracranial lesions. However, they can potentially increase the dose to hippocampus (H) causing neurocognitive toxicity during the first four months after irradiation. The purpose of this study was to assess the feasibility of hippocampal-sparing (HS) treatment plans in 22 patients with brain metastasis treated with VMAT technique. Firstly, we retrospectively analyzed hippocampal doses in all 22 VMAT original (not hippocampal-sparing, NHS) plans...
November 10, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29117865/correction-to-improved-plan-quality-with-automated-radiotherapy-planning-for-whole-brain-with-hippocampus-sparing-a-comparison-to-the-rtog-0933-trial
#10
J Krayenbuehl, M Di Martino, M Guckenberger, N Andratschke
In the original publication [1] figure legends 2 and 4 have been swapped. The original article was updated to rectify this error.
November 8, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29089622/prognosis-of-hippocampal-function-after-sub-lethal-irradiation-brain-injury-in-patients-with-nasopharyngeal-carcinoma
#11
Sharon Chia-Ju Chen, Yoshifumi Abe, Pen-Tzu Fang, Ya-Ju Hsieh, Yung-I Yang, Tzu-Ying Lu, Shoji Oda, Hiroshi Mitani, Shi-Long Lian, Yu-Chang Tyan, Chih-Jen Huang, Tatsuhiro Hisatsune
This work emphasizes the value of assessing hippocampal function by making a timely MRI-based prognosis following a minor dose of hippocampal irradiation after nasopharyngeal carcinomas (NPC) radiotherapy. A quasi-experiment with case-control design and functional assessments (e.g., neuroimaging analysis with fMRI) was conducted to assess hippocampal function after radiotherapy. We delivered 70 Gy of irradiation to nasopharyngeal carcinomas by 6MV helical radiotherapy and collected data from twenty NPC patients and 24 healthy age-matched subjects...
October 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28969706/improved-plan-quality-with-automated-radiotherapy-planning-for-whole-brain-with-hippocampus-sparing-a-comparison-to-the-rtog-0933-trial
#12
J Krayenbuehl, M Di Martino, M Guckenberger, N Andratschke
BACKGROUND: Whole-brain radiation therapy (WBRT) with hippocampus sparing (HS) has been investigated by the radiation oncology working group (RTOG) 0933 trial for patients with multiple brain metastases. They showed a decrease of adverse neurocognitive effects with HS WBRT compared to WBRT alone. With the development of automated treatment planning system (aTPS) in the last years, a standardization of the plan quality at a high level was achieved. The goal of this study was to evaluate the feasibility of using an aTPS for the treatment of HS WBRT and see if the RTOG 0933 dose constraints could be achieved and improved...
October 2, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28951047/hippocampal-dose-during-linac-based-stereotactic-radiotherapy-for-brain-metastases-an-observational-study
#13
Alba Fiorentino, Umberto Tebano, Gianluisa Sicignano, Francesco Ricchetti, Gioacchino Di Paola, Dario Aiello, Niccolò Giaj-Levra, Rosario Mazzola, Sergio Fersino, Ruggero Ruggieri, Filippo Alongi
INTRODUCTION: Aim of the present study is to evaluate homolateral and contralateral hippocampus (H-H, C-H, respectively) dose during Fractionated Stereotactic Radiotherapy (FSRT) or Radiosurgery (SRS) for brain metastases (BM). MATERIALS & METHODS: Patients with BM<5, size≤30mm, KPS≥80 and a life expectancy>3months, were considered for SRS/FSRT (total dose 15-30Gy, 1-5 fractions). For each BM, a Flattening Filter Free (FFF) Volumetric Modulated Arc Therapy (VMAT) plan was generated with one or two arcs...
September 23, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28893524/-hippocampus-brainstem-and-brain-dose-volume-constraints-for-fractionated-3-d-radiotherapy-and-for-stereotactic-radiation-therapy-limits-and-perspectives
#14
REVIEW
M Gérard, R Jumeau, B Pichon, J Biau, E Blais, J Horion, G Noël
Cerebral radiation-induced toxicities after radiotherapy (RT) of brain tumors are frequent. The protection of organs at risk (OAR) is crucial, especially for brain tumors, to preserve cognition in cancer survivors. Dose constraints of cerebral OAR used in conventional RT, radiosurgery (SRS) and stereotactic radiotherapy (SRT) are debated. In fact, they are based on historical cohorts or calculated with old mathematical models. Values of α/β ratio of cerebral OAR are also controversial leading to misestimate the equivalent dose in 2Gy fractions or the biological equivalent dose, especially during hypofractionated RT...
October 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28866326/progesterone-improves-neurocognitive-outcomes-following-therapeutic-cranial-irradiation-in-mice
#15
Seema Yousuf, Daniel J Brat, Hui-Kuo Shu, Ya Wang, Donald G Stein, Fahim Atif
Despite improved therapeutic methods, CNS toxicity resulting from cancer treatment remains a major cause of post-treatment morbidity. More than half of adult patients with cranial irradiation for brain cancer develop neurobehavioral/cognitive deficits that severely impact quality of life. We examined the neuroprotective effects of the neurosteroid progesterone (PROG) against ionizing radiation (IR)-induced neurobehavioral/cognitive deficits in mice. Male C57/BL mice were exposed to one of two fractionated dose regimens of IR (3Gy×3 or 3Gy×5)...
September 14, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28837234/a-precision-3d-conformal-treatment-technique-in-rats-application-to-whole-brain-radiotherapy-with-hippocampal-avoidance
#16
Suk W Yoon, Christina K Cramer, Devin A Miles, Michael H Reinsvold, Kyeung M Joo, David G Kirsch, Mark Oldham
PURPOSE: To develop and validate three-dimensional (3D) conformal hippocampal sparing whole-brain radiation therapy (HA-WBRT) for Wistar rats utilizing precision 3D-printed immobilization and micro-blocks. This technique paves the way for future preclinical studies investigating brain treatments that reduce neurotoxicity. METHODS AND MATERIALS: A novel preclinical treatment planning and delivery process was developed to enable precision 3D conformal treatment and hippocampal avoidance capability for the Xrad 225cx small animal irradiator...
August 24, 2017: Medical Physics
https://www.readbyqxmd.com/read/28830202/radiological-distribution-of-brain-metastases-and-its-implication-for-the-hippocampus-avoidance-in-whole-brain-radiotherapy-approach
#17
Yi-Min Han, Gang Cai, Wei-Min Chai, Cheng Xu, Lu Cao, Dan Ou, Jia-Yi Chen, Youlia M Kirova
OBJECTIVE: Hippocampus avoidance in whole brain radiotherapy (HA-WBRT) offers the feasibility of less-impaired cognitive function than conventional WBRT. The study aims to assess the radiological distribution of brain metastases (BMs) with relation to the hippocampus and peri-hippocampus region as defined by the RTOG 0933 for better understanding of margin definition in HA-WBRT treatment planning. METHODS: Consecutive patients with diagnosis of BM from enhanced MRI between March 2011 and July 2016 were analysed...
November 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28731074/left-hippocampus-sparing-whole-brain-radiotherapy-wbrt-a-planning-study
#18
Tomas Kazda, Miroslav Vrzal, Tomas Prochazka, Petr Dvoracek, Petr Burkon, Petr Pospisil, Adam Dziacky, Tomas Nikl, Radim Jancalek, Pavel Slampa, Radek Lakomy
AIMS: Unilateral sparing of the dominant (left) hippocampus during whole brain radiotherapy (WBRT) could mitigate cognitive decline, especially verbal memory, similar to the widely investigated bilateral hippocampus avoidance (HA-WBRT). The aim of this planning study is dosimetrical comparison of HA-WBRT with only left hippocampus sparing (LHA-WBRT) plans. METHODS: HA-WBRT plans for 10 patients were prepared in accordance with RTOG 0933 trial and served as baseline for comparisons with several LHA-WBRT plans prepared with an effort: 1) to maintain the same left hippocampus dosimetry ("BEST PTV") and 2) to maintain same dosimetry in planning target volume as in HA-WBRT ("BEST LH")...
July 20, 2017: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/28693284/%C3%AE-human-chorionic-gonadotropin-secreting-intracranial-germ-cell-tumor-associated-with-high-testosterone-in-an-adult-man-a-case-report
#19
Wen-Ping Yang, Hung-Yu Chien, Yi-Chun Lin
A 38-year-old male patient presented with general weakness, polydipsia and a body weight loss of 10 kg in two years. Hypopituitarism with central hypothyroidism and central adrenal insufficiency were noted at Taipei City Hospital (Taipei, Taiwan). However, hypogonadotropic hypergonadism was also observed. The patient was diagnosed with an intracranial β-human chorionic gonadotropin (β-hCG) secreting germ-cell tumor, and brain magnetic resonance imaging revealed that the tumor involved the pineal gland, stalk, posterior pituitary gland, right basal ganglion, hypothalamus, corpus callosum and posterior hippocampus...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28668331/total-abdominal-irradiation-exposure-impairs-cognitive-function-involving-mir-34a-5p-bdnf-axis
#20
Ming Cui, Huiwen Xiao, Yuan Li, Jiali Dong, Dan Luo, Hang Li, Guoxing Feng, Haichao Wang, Saijun Fan
Radiotherapy is often employed to treat abdominal and pelvic malignancies, but is frequently accompanied by diverse acute and chronic local injuries. It was previously unknown whether abdominal and pelvic radiotherapy impairs distant cognitive dysfunction. In the present study, we demonstrated that total abdominal irradiation (TAI) exposure caused cognitive deficits in mouse models. Mechanically, microarray assay analysis revealed that TAI elevated the expression level of miR-34a-5p in small intestine tissues and peripheral blood (PD), which targeted the 3'UTR of Brain-derived neurotrophic factor (Bdnf) mRNA in hippocampus to mediate cognitive dysfunction...
September 2017: Biochimica et Biophysica Acta
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