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Hippocampus radiotherapy

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https://www.readbyqxmd.com/read/28611367/the-hippocampus-sparing-volume-modulated-arc-therapy-does-not-influence-plan-quality-on-locally-advanced-nasopharyngeal-carcinoma-patients
#1
Wendong Gu, Qilin Li, Dan Xi, Ye Tian, Juncong Mo, Honglei Pei
Irradiation on hippocampus would lead to neuro-cognitive dysfunction in locally advanced nasopharyneal carcinoma (LA-NPC) patients accepting radiotherapy. Our study here aimed to investigate if undergoing hippocampus sparing (HS) volume modulated arc therapy (VMAT) would influence the plan quality in LA NPC patients. We designed three kinds of radiotherapeutic plans for 11 LA NPC patients: conventional VMAT (C-VMAT), HS-VMAT and HS intensity modulated radiation therapy with dynamic multileaf collimator (HS-dMLC)...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28510808/development-of-a-contouring-guide-in-three-different-head-set-ups-for-hippocampal-sparing-radiotherapy-a-practical-approach
#2
Saide Di Biase, Marianna Trignani, Luciana Caravatta, Paul Ioan Voicu, Clelia Di Carlo, Annamaria Vinciguerra, Antonietta Augurio, Francesca Perrotti, Valentina Panara, Domenico Genovesi
BACKGROUNDS: Irradiation of the hippocampus plays a role in neurocognitive toxicity. Its delineation is complex and in practice different head position can vary hippocampus morphology on axial images; so atlas in a single standard position can result ineffective to describe different hippocampal morphologies in different head set-up. The purpose of our study was to develop a guide based on magnetic resonance imaging for hippocampus delineation in three different head set-ups. MATERIALS AND METHODS: Three patients were selected to elaborate our guide...
May 16, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28415806/lithium-protects-hippocampal-progenitors-cognitive-performance-and-hypothalamus-pituitary-function-after-irradiation-to-the-juvenile-rat-brain
#3
Kai Zhou, Cuicui Xie, Malin Wickström, Amalia M Dolga, Yaodong Zhang, Tao Li, Yiran Xu, Carsten Culmsee, Per Kogner, Changlian Zhu, Klas Blomgren
Cranial radiotherapy in children typically causes delayed and progressive cognitive dysfunction and there is no effective preventive strategy for radiation-induced cognitive impairments. Here we show that lithium treatment reduced irradiation-induced progenitor cell death in the subgranular zone of the hippocampus, and subsequently ameliorated irradiation-reduced neurogenesis and astrogenesis in the juvenile rat brain. Irradiation-induced memory impairment, motor hyperactivity and anxiety-like behaviour were normalized by lithium treatment...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28340924/hippocampal-sparing-whole-brain-radiotherapy-for-lung-cancer
#4
REVIEW
Ren Zhao, Wei Kong, Jun Shang, Hong Zhe, Yan-Yang Wang
Brain metastases occur in 20% to 40% of lung cancer patients. Whole-brain radiotherapy (WBRT) has long been considered the treatment of choice for many patients with lung cancer, because of its wide availability, ease of delivery, and effectiveness in prolonging survival. However, WBRT is also associated with several side effects, such as decline in memory and other cognitive functions. There exists significant preclinical and clinical evidence that radiation-induced injury to the hippocampus correlates with neurocognitive decline of patients who receive WBRT...
March 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28333139/inhibition-of-autophagy-prevents-irradiation-induced-neural-stem-and-progenitor-cell-death-in-the-juvenile-mouse-brain
#5
Yafeng Wang, Kai Zhou, Tao Li, Yiran Xu, Cuicui Xie, Yanyan Sun, Yaodong Zhang, Juan Rodriguez, Klas Blomgren, Changlian Zhu
Radiotherapy is an effective tool in the treatment of malignant brain tumors. However, damage to brain stem and progenitor cells constitutes a major problem and is associated with long-term side effects. Autophagy has been shown to be involved in cell death, and the purpose of this study was to evaluate the effect of autophagy inhibition on neural stem and progenitor cell death in the juvenile brain. Ten-day-old selective Atg7 knockout (KO) mice and wild-type (WT) littermates were subjected to a single 6Gy dose of whole-brain irradiation...
March 23, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28237294/automatic-planning-on-hippocampal-avoidance-whole-brain-radiotherapy
#6
Shuo Wang, Dandan Zheng, Chi Zhang, Rongtao Ma, Nathan R Bennion, Yu Lei, Xiaofeng Zhu, Charles A Enke, Sumin Zhou
Mounting evidence suggests that radiation-induced damage to the hippocampus plays a role in neurocognitive decline for patients receiving whole-brain radiotherapy (WBRT). Hippocampal avoidance whole-brain radiotherapy (HA-WBRT) has been proposed to reduce the putative neurocognitive deficits by limiting the dose to the hippocampus. However, urgency of palliation for patients as well as the complexities of the treatment planning may be barriers to protocol enrollment to accumulate further clinical evidence. This warrants expedited quality planning of HA-WBRT...
April 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28063694/post-wbrt-cognitive-impairment-and-hippocampal-neuronal-depletion-measured-by-in-vivo-metabolic-mr-spectroscopy-results-of-prospective-investigational-study
#7
Petr Pospisil, Tomas Kazda, Ludmila Hynkova, Martin Bulik, Marie Dobiaskova, Petr Burkon, Nadia N Laack, Pavel Slampa, Radim Jancalek
BACKGROUND AND PURPOSE: The aim of this prospective study is to evaluate post-whole brain radiotherapy (WBRT) changes in hippocampal concentration of N-acetylaspartate (h-tNAA) as a marker of neuronal loss and to correlate those changes to neurocognitive function. MATERIAL AND METHODS: Thirty-five patients with brain metastases underwent baseline single slice multi-voxel MR spectroscopy (MRS) examination for measurement of hippocampal h-tNAA together with baseline battery of neurocognitive tests focused on memory (Auditory Verbal Learning Test and Brief Visuospatial Memory Test - Revised) as well as quality of life questionnaires (EORTC QLQ-C30 a EORTC QLQ-BN20)...
March 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28048352/th-ef-brb-01-best-in-physics-therapy-dosimetric-comparison-of-4%C3%AF-and-clinical-imrt-for-cortex-sparing-high-grade-glioma-treatment
#8
K Woods, R Karunamuni, A Tran, V Yu, D Nguyen, J Hattangadi-Gluth, K Sheng
PURPOSE: Thinning of the cerebral cortex has been observed in patients treated with fractionated partial brain radiation therapy and may contribute to cognitive decline following treatment. The extent of this thinning is dose-dependent, and was shown comparable to that of neurodegenerative diseases such as Alzheimer's disease at one year post-therapy. This study investigates whether 4π radiotherapy can enable better sparing of the cortex and other critical structures when compared to conventional clinical IMRT plans...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047933/su-f-t-401-three-dimensional-conformal-planning-using-low-segment-multi-criteria-optimization-for-hippocampal-avoidance-whole-brain-radiotherapy
#9
X Zhang, J Penagaricano, G Narayanasamy, R Griffin, S Maraboyina, N Paudel, C Peter, S Morrill
PURPOSE: Hippocampus avoidance whole brain radiotherapy (HA-WBRT) has been shown to reduce the risk of neurocognitive dysfunction. This type of treatment has the potential of insurance company payment denial due to increased cost of intensity modulated radiotherapy (IMRT), while the accepted modality for WBRT is three-dimensional conformal radiotherapy (3DCRT). The purpose of this study is to assess HA-WBRT treatment plans using 3DCRT and multi-criteria optimization (MCO) that meets the RTOG 0933 criteria...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047896/su-f-t-339-comparison-between-coplanar-and-non-coplanar-rapidarc-approach-of-hippocampal-sparing-whole-brain-radiotherapy
#10
B Liu, J Kim
PURPOSE: To compare the dosimetry of coplanar and non-coplanar RapidArc whole brain plans for hippocampal sparing METHODS: We studied the RapidArc plans of patient with brain metastases, with the prescription of 3750 cGy in 15 fractions. The coplanar approach used a full clockwise (CW) arc and a full counterclockwise (CCW) arc, with the couch angle to be 0°. The non-coplanar approach used a full arc with a couch angle of 0°, and a partial arc with a couch angle of 90°. Treatment planning system is Eclipse Ver...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27982041/mechanisms-of-radiotherapy-associated-cognitive-disability-in-patients-with-brain-tumours
#11
REVIEW
Milan T Makale, Carrie R McDonald, Jona A Hattangadi-Gluth, Santosh Kesari
Standard treatment of primary and metastatic brain tumours includes high-dose megavoltage-range radiation to the cranial vault. About half of patients survive >6 months, and many attain long-term control or cure. However, 50-90% of survivors exhibit disabling cognitive dysfunction. The radiation-associated cognitive syndrome is poorly understood and has no effective prevention or long-term treatment. Attention has primarily focused on mechanisms of disability that appear at 6 months to 1 year after radiotherapy...
January 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/27893434/neuroinflammatory-and-cognitive-consequences-of-combined-radiation-and-immunotherapy-in-a-novel-preclinical-model
#12
Gwendolyn J McGinnis, David Friedman, Kristina H Young, Eileen Ruth S Torres, Charles R Thomas, Michael J Gough, Jacob Raber
BACKGROUND: Cancer patients often report behavioral and cognitive changes following cancer treatment. These effects can be seen in patients who have not yet received treatment or have received only peripheral (non-brain) irradiation. Novel treatments combining radiotherapy (RT) and immunotherapy (IT) demonstrate remarkable efficacy with respect to tumor outcomes by enhancing the proinflammatory environment in the tumor. However, a proinflammatory environment in the brain mediates cognitive impairments in other neurological disorders and may affect brain function in cancer patients receiving these novel treatments...
February 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/27797223/hippocampal-sparing-whole-brain-radiotherapy-and-integrated-simultaneous-boost-vs-stereotactic-radiosurgery-boost-a-comparative-dosimetric-planning-study
#13
Soon Keat Cheah, Thomas Matthews, Bin Sing Teh
BACKGROUND: Whole brain radiotherapy (WBRT) and stereotactic radiosurgery were frequently used to palliate patients with brain metastases. It remains controversial which modality or combination of therapy is superior especially in the setting of limited number of brain metastases. The availability of newer medical therapy that improves survival highlighted the importance of reducing long term radiation toxicity associated with WBRT. In this study, we aim to demonstrate the hippocampal sparing technique with whole brain and integrated simultaneous boost Materials and Methods: Planning data from 10 patients with 1-5 brain metastases treated with SRS were identified...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27692518/treatment-planning-strategy-for-whole-brain-radiotherapy-with-hippocampal-sparing-and-simultaneous-integrated-boost-for-multiple-brain-metastases-using-intensity-modulated-arc-therapy
#14
Damodar Pokhrel, Sumit Sood, Christopher McClinton, Xinglei Shen, Christopher Lominska, Habeeb Saleh, Rajeev Badkul, Hongyu Jiang, Melissa Mitchell, Fen Wang
PURPOSE: To retrospectively evaluate the accuracy, plan quality and efficiency of intensity-modulated arc therapy (IMAT) for hippocampal sparing whole-brain radiotherapy (HS-WBRT) with simultaneous integrated boost (SIB) in patients with multiple brain metastases (m-BM). MATERIALS AND METHODS: A total of 5 patients with m-BM were retrospectively replanned for HS-WBRT with SIB using IMAT treatment planning. The hippocampus was contoured on diagnostic T1-weighted magnetic resonance imaging (MRI) which had been fused with the planning CT image set...
January 2016: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/27609371/hippocampal-sparing-radiotherapy-for-glioblastoma-patients-a-planning-study-using-volumetric-modulated-arc-therapy
#15
Jan Hofmaier, Steffi Kantz, Matthias Söhn, Oliver S Dohm, Stefan Bächle, Markus Alber, Katia Parodi, Claus Belka, Maximilian Niyazi
BACKGROUND: The purpose of this study is to investigate the potential to reduce exposure of the contralateral hippocampus in radiotherapy for glioblastoma using volumetric modulated arc therapy (VMAT). METHODS: Datasets of 27 patients who had received 3D conformal radiotherapy (3D-CRT) for glioblastoma with a prescribed dose of 60Gy in fractions of 2Gy were included in this planning study. VMAT plans were optimized with the aim to reduce the dose to the contralateral hippocampus as much as possible without compromising other parameters...
September 8, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27587045/technical-note-plastimatch-mabs-an-open-source-tool-for-automatic-image-segmentation
#16
Paolo Zaffino, Patrik Raudaschl, Karl Fritscher, Gregory C Sharp, Maria Francesca Spadea
PURPOSE: Multiatlas based segmentation is largely used in many clinical and research applications. Due to its good performances, it has recently been included in some commercial platforms for radiotherapy planning and surgery guidance. Anyway, to date, a software with no restrictions about the anatomical district and image modality is still missing. In this paper we introduce plastimatch mabs, an open source software that can be used with any image modality for automatic segmentation...
September 2016: Medical Physics
https://www.readbyqxmd.com/read/27523410/-radiotherapy-for-brain-metastases
#17
I Latorzeff, D Antoni, S Gaudaire-Josset, L Feuvret, A Tallet-Richard, G Truc, G Noël
Radiotherapy for brain metastases has become more multifaceted. Indeed, with the improvement of the patient's life expectancy, side effects must be undeniably avoided and the retreatments or multiple treatments are common. The cognitive side effects should be warned and the most modern techniques of radiation therapy are used regularly to reach this goal. The new classifications of patients with brain metastases help guiding treatment more appropriately. Stereotactic radiotherapy has supplanted whole brain radiation therapy both for patients with metastases in place and for those who underwent surgery...
September 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/27442663/radiation-induced-functional-connectivity-alterations-in-nasopharyngeal-carcinoma-patients-with-radiotherapy
#18
Qiongmin Ma, Donglin Wu, Ling-Li Zeng, Hui Shen, Dewen Hu, Shijun Qiu
The study aims to investigate the radiation-induced brain functional alterations in nasopharyngeal carcinoma (NPC) patients who received radiotherapy (RT) using functional magnetic resonance imaging (fMRI) and statistic scale.The fMRI data of 35 NPC patients with RT and 24 demographically matched untreated NPC patients were acquired. Montreal Cognitive Assessment (MoCA) was also measured to evaluate their global cognition performance. Multivariate pattern analysis was performed to find the significantly altered functional connections between these 2 groups, while the linear correlation level was detected between the altered functional connections and the MoCA scores...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27334276/intensity-modulated-proton-therapy-volumetric-modulated-arc-therapy-and-3d%C3%A2-conformal-radiotherapy-in-anaplastic-astrocytoma-and-glioblastoma-a-dosimetric-comparison
#19
COMPARATIVE STUDY
S Adeberg, S B Harrabi, N Bougatf, D Bernhardt, J Rieber, S A Koerber, M Syed, T Sprave, A Mohr, A Abdollahi, T Haberer, S E Combs, K Herfarth, J Debus, S Rieken
PURPOSE: The prognosis for high-grade glioma (HGG) patients is poor; thus, treatment-related side effects need to be minimized to conserve quality of life and functionality. Advanced techniques such as proton radiation therapy (PRT) and volumetric-modulated arc therapy (VMAT) may potentially further reduce the frequency and severity of radiogenic impairment. MATERIALS AND METHODS: We retrospectively assessed 12 HGG patients who had undergone postoperative intensity-modulated proton therapy (IMPT)...
November 2016: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/27313693/treatment-of-brain-metastases-of-renal-cell-cancer-with-combined-hypofractionated-stereotactic-radiotherapy-and-whole-brain-radiotherapy-with-hippocampal-sparing
#20
David Vrána, Hana Študentová, Marcel Matzenauer, Zuzana Vlachová, Karel Cwiertka, David Gremlica, Ondřej Kalita
Renal cell cancer patients with brain metastatic disease generally have poor prognosis. Treatment options include surgery, radiotherapy, targeted therapy or best supportive care with respect to disease burden, patient preference and performance status. In the present case report the radiotherapy technique combining whole brain radiotherapy with hippocampal sparing (hippocampal avoidance whole brain radiotherapy HA-WBRT) and hypofractionated stereotactic radiotherapy (SRT) of the brain metastases is performed in a patient with metastatic renal cell carcinoma...
June 2016: Oncology Letters
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