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https://www.readbyqxmd.com/read/28303616/bike-peptides-a-ride-through-the-membrane
#1
Júlia García-Pindado, Soledad Royo, Meritxell Teixidó, Ernest Giralt
Several natural peptides have a biaryl or biaryl ether motif in their biologically active structures. A model bicyclic pentapeptide containing a biaryl bridge has been synthesized by solid-phase peptide synthesis combining on-resin Suzuki and Miyaura cross-coupling reactions. Its biological properties in terms of permeability, stability and cytotoxicity have been studied, demonstrating the positive contribution of the biaryl bridge, excellent membrane penetration and serum stability Copyright © 2017 European Peptide Society and John Wiley & Sons, Ltd...
March 16, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28268718/a-new-crank-arm-based-load-cell-with-built-in-conditioning-circuit-and-strain-gages-to-measure-the-components-of-the-force-applied-by-a-cyclist
#2
Andre V Pigatto, Karina O A Moura, Gabriela W Favieiro, Alexandre Balbinot
This report describes the development of a force platform based on instrumented load cells with built-in conditioning circuit and strain gages to measure and acquire the components of the force that is applied to the bike crank arm during pedaling in real conditions, and save them on a SD Card. To accomplish that, a complete new crank arm 3D solid model was developed in the SolidWorks, with dimensions equivalent to a commercial crank set and compatible with a conventional road bike, but with a compartment to support all the electronics necessary to measure 3 components of the force applied to the pedal during pedaling...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226906/a-new-crank-arm-based-load-cell-with-built-in-conditioning-circuit-and-strain-gages-to-measure-the-components-of-the-force-applied-by-a-cyclist
#3
Andre V Pigatto, Karina O A Moura, Gabriela W Favieiro, Alexandre Balbinot, Andre V Pigatto, Karina O A Moura, Gabriela W Favieiro, Alexandre Balbinot, Karina O A Moura, Gabriela W Favieiro, Alexandre Balbinot, Andre V Pigatto
This report describes the development of a force platform based on instrumented load cells with built-in conditioning circuit and strain gages to measure and acquire the components of the force that is applied to the bike crank arm during pedaling in real conditions, and save them on a SD Card. To accomplish that, a complete new crank arm 3D solid model was developed in the SolidWorks, with dimensions equivalent to a commercial crank set and compatible with a conventional road bike, but with a compartment to support all the electronics necessary to measure 3 components of the force applied to the pedal during pedaling...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28223189/the-unrealised-potential-of-bike-share-schemes-to-influence-population-physical-activity-levels-a-narrative-review
#4
Adrian Bauman, Melanie Crane, Bradley Alan Drayton, Sylvia Titze
The recent proliferation of bike share schemes (BSS, also known as public bicycle use programs) in many cities has focused attention on their potential for reducing motorised traffic congestion, improving air quality and reducing car use. Since 2005, hundreds of bike share schemes have been implemented in many cities, with bike share usage patterns monitored in many of them. This paper assesses the development of BSS and provides a rationale for their potential health benefits. The key research question, as yet unanswered, is whether BSS themselves can contribute to improving population health, particularly through increasing population cycling, which would increase population levels of health-enhancing physical activity...
February 18, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28116943/dental-trauma-and-bicycle-safety-a-report-in-italian-children-and-adolescents
#5
Francesca Amadori, Elena Bardellini, Alessandro Copeta, Giulio Conti, Valerio Villa, Alessandra Majorana
OBJECTIVES: This retrospective study aims to analyze the pattern of oro-facial trauma from bicycle accidents in Italian children and adolescents, focusing on the safety devices used. METHODS: The medical records of 1405 patients of the Dental Clinic of the University of Brescia, between the age of 0 to 18, who experienced a dento-facial trauma from the use of a bicycle, were analyzed. Data regarding age, gender, weight, height, dominant hand, type of bicycle, use of safety devices, location and type of dental trauma, teeth involved, bone fractures and soft tissue lesions were recorded...
January 24, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/28088011/particulates-and-noise-exposure-during-bicycle-bus-and-car-commuting-a-study-in-three-european-cities
#6
Enembe O Okokon, Tarja Yli-Tuomi, Anu W Turunen, Pekka Taimisto, Arto Pennanen, Ilias Vouitsis, Zissis Samaras, Marita Voogt, Menno Keuken, Timo Lanki
BACKGROUND: In order to curb traffic-related air pollution and its impact on the physical environment, contemporary city commuters are encouraged to shift from private car use to active or public transport modes. However, personal exposures to particulate matter (PM), black carbon and noise during commuting may be substantial. Therefore, studies comparing exposures during recommended modes of transport versus car trips are needed. METHODS: We measured personal exposure to various-sized particulates, soot, and noise during commuting by bicycle, bus and car in three European cities: Helsinki in Finland, Rotterdam in the Netherlands and Thessaloniki in Greece using portable monitoring devices...
April 2017: Environmental Research
https://www.readbyqxmd.com/read/28033138/consequences-of-underestimating-impalement-bicycle-handlebar-injuries-in-children
#7
Carmen T Ramos-Irizarry, Shakeva Swain, Samantha Troncoso-Munoz, Malvina Duncan
Impalement bicycle handlebar trauma injuries are rare; however, on initial assessment, they have the potential of being underestimated. We reviewed our prospective trauma database of 3,894 patients for all bicycle injuries from January 2010 to May 2015. Isolated pedal bike injuries were reported in 2.6% (N = 101) of the patients who were admitted to the trauma service. Fifteen patients suffered direct handlebar trauma. Patients were grouped into blunt trauma (n = 12) and impalement trauma (n = 3). We examined gender, age, injury severity score (ISS), Glasgow Coma Scale score, use of protective devices, need for surgical intervention, need for intensive care (ICU), and hospital length of stay...
January 2017: Journal of Trauma Nursing: the Official Journal of the Society of Trauma Nurses
https://www.readbyqxmd.com/read/27995048/proposal-for-optimal-placement-platform-of-bikes-using-queueing-networks
#8
Shinya Mizuno, Shogo Iwamoto, Mutsumi Seki, Naokazu Yamaki
In recent social experiments, rental motorbikes and rental bicycles have been arranged at nodes, and environments where users can ride these bikes have been improved. When people borrow bikes, they return them to nearby nodes. Some experiments have been conducted using the models of Hamachari of Yokohama, the Niigata Rental Cycle, and Bicing. However, from these experiments, the effectiveness of distributing bikes was unclear, and many models were discontinued midway. Thus, we need to consider whether these models are effectively designed to represent the distribution system...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27940760/risk-factors-for-bicycling-injuries-in-children-and-adolescents-a-systematic-review
#9
REVIEW
Tania E Embree, Nicole T R Romanow, Maya S Djerboua, Natalie J Morgunov, Jacqueline J Bourdeaux, Brent E Hagel
CONTEXT: Child and adolescent bicycling is beneficial, but injuries occur and can be severe and costly. OBJECTIVE: To systematically review the individual and environmental factors associated with bicycling injury risk in children and adolescents. DATA SOURCES: Fourteen electronic databases were searched. STUDY SELECTION: Two authors independently assessed potentially relevant articles for eligibility. The inclusion criteria were as follows: bicyclists younger than 20 years old; examined individual and environmental characteristics of bicycling crashes; compared injured and uninjured bicyclists or bicyclists with different types or severity of injury; study designs with a predetermined comparison group; and published in English from January 1990 to May 2015...
November 2016: Pediatrics
https://www.readbyqxmd.com/read/27939970/quantifying-bicycle-network-connectivity
#10
Michael Lowry, Tracy Hadden Loh
The intent of this study was to compare bicycle network connectivity for different types of bicyclists and different neighborhoods. Connectivity was defined as the ability to reach important destinations, such as grocery stores, banks, and elementary schools, via pathways or roads with low vehicle volumes and low speed limits. The analysis was conducted for 28 neighborhoods in Seattle, Washington under existing conditions and for a proposed bicycle master plan, which when complete will provide over 700 new bicycle facilities, including protected bike lanes, neighborhood greenways, and multi-use trails...
February 2017: Preventive Medicine
https://www.readbyqxmd.com/read/27925109/analysis-of-factors-associated-with-traffic-accidents-of-cyclists-attended-in-brazilian-state-capitals
#11
Carlos Augusto Moreira de Sousa, Camila Alves Bahia, Patrícia Constantino
Introduction: Brazil has the sixth largest bicycles fleet in the world and bicycle is the most used individual transport vehicle in the country. Few studies address the issue of cyclists' accidents and factors that contribute to or prevent this event. Methodology: VIVA is a cross-sectional survey and is part of the Violence and Accidents Surveillance System, Brazilian Ministry of Health. We used complex sampling and subsequent data review through multivariate logistic regression and calculation of the respective odds ratios...
December 2016: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/27904756/ct-negative-mri-gre-positive-primary-motor-cortex-contusion-causing-isolated-foot-drop
#12
Alexander M Tucker, Tianyi Niu, Daniel T Nagasawa, Richard Everson, Shaina Sedighim, Manuel M Buitrago Blanco
BACKGROUND: Isolated acute foot drop due to traumatic brain injury is exceedingly rare and is often misdiagnosed during initial evaluation. Here, we present the case of a patient who presented with left foot drop after falling off a bicycle. CASE DESCRIPTION: The patient is a 55-year-old male who was mountain biking when he fell, hit his head, and lost consciousness. Neurologic examination of the left leg revealed foot drop, no sensory deficits, and 3+ reflexes at the knee and ankle with clonus...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27890161/primary-or-secondary-tasks-dual-task-interference-between-cyclist-hazard-perception-and-cadence-control-using-cross-modal-sensory-aids-with-rider-assistance-bike-computers
#13
Chao-Yang Yang, Cheng-Tse Wu
This research investigated the risks involved in bicycle riding while using various sensory modalities to deliver training information. To understand the risks associated with using bike computers, this study evaluated hazard perception performance through lab-based simulations of authentic riding conditions. Analysing hazard sensitivity (d') of signal detection theory, the rider's response time, and eye glances provided insights into the risks of using bike computers. In this study, 30 participants were tested with eight hazard perception tasks while they maintained a cadence of 60 ± 5 RPM and used bike computers with different sensory displays, namely visual, auditory, and tactile feedback signals...
March 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/27822361/serious-bicycle-crash-injury-in-chiropractic-practice-a-case-report-of-delayed-diagnosis
#14
Lars Uhrenholt
BACKGROUND: Bicyclists are vulnerable road users and are at risk of serious spinal injury if involved in traffic crashes. In Denmark approximately 25 bicyclists are killed each year and some 20.000 bicycle related casualties are registered in the National Patient Registry each year. In addition to these figures, a large number of casualties remain unregistered despite injury. Many of the casualties will consult chiropractors in primary practice with or without preceding evaluation in the established emergency care facilities...
2016: Chiropractic & Manual Therapies
https://www.readbyqxmd.com/read/27789223/from-sedentary-to-active-school-commute-multi-level-factors-associated-with-travel-mode-shifts
#15
Chanam Lee, Jeongjae Yoon, Xuemei Zhu
Previous research has examined personal, social, and environmental correlates of active commuting to school, but most were cross-sectional and mode choice studies. This exploratory case study utilized a retrospective natural experiment opportunity, where a group of students transferred to a new school, and therefore experienced changes in their home-to-school travel environments. It examined whether such changes led to mode shifts from sedentary (car or school bus) to active (walking and bicycling) and what factors were associated with those shifts...
February 2017: Preventive Medicine
https://www.readbyqxmd.com/read/27713109/population-level-exposure-to-particulate-air-pollution-during-active-travel-planning-for-low-exposure-health-promoting-cities
#16
Steve Hankey, Greg Lindsey, Julian D Marshall
BACKGROUND: Providing infrastructure and land uses to encourage active travel (i.e., bicycling and walking) are promising strategies for designing health-promoting cities. Population-level exposure to air pollution during active travel is understudied. OBJECTIVES: To (1) investigate population-level patterns in exposure during active travel, based on spatial estimates of bicycle traffic, pedestrian traffic, and particulate concentrations; and, (2) assess how those exposure patterns are associated with the built environment...
October 7, 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27712198/performance-and-physiological-effects-of-different-descending-strategies-for-cross-country-mountain-biking
#17
Matthew C Miller, Paul W Macdermid, Phil W Fink, Stephen R Stannard
This study investigated the performance-related feasibility and physiological benefits of purposefully eliminating propulsive work while descending in mountain biking and compared values to those measured during road descending. Participants cycled uphill on a road at race pace before descending over three conditions (off-road pedalling; off-road coasting; road coasting). Relatively low power output during off-road pedalling was associated with a greater oxygen uptake (p < .01) when compared with off-road coasting despite no difference in vibration exposure (p > ...
April 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/27679447/modeling-and-optimization-of-airbag-helmets-for-preventing-head-injuries-in-bicycling
#18
Mehmet Kurt, Kaveh Laksari, Calvin Kuo, Gerald A Grant, David B Camarillo
Bicycling is the leading cause of sports-related traumatic brain injury. Most of the current bike helmets are made of expanded polystyrene (EPS) foam and ultimately designed to prevent blunt trauma, e.g., skull fracture. However, these helmets have limited effectiveness in preventing brain injuries. With the availability of high-rate micro-electrical-mechanical systems sensors and high energy density batteries, a new class of helmets, i.e., expandable helmets, can sense an impending collision and expand to protect the head...
April 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/27672561/changes-in-bicycling-over-time-associated-with-a-new-bike-lane-relations-with-kilocalories-energy-expenditure-and-body-mass-index
#19
Barbara B Brown, Douglas Tharp, Calvin P Tribby, Ken R Smith, Harvey J Miller, Carol M Werner
Although bicycling has been related to positive health indicators, few studies examine health-related measures associated with non-competitive community cycling before and after cycling infrastructure improvements. This study examined cycling changes in a neighborhood receiving a bike lane, light rail, and other "complete street" improvements. Participants wore accelerometers and global positioning system (GPS) data loggers for one week in both 2012 and 2013, pre- and post- construction completion. Participants sampled within 2 km of the complete street improvements had the following patterns of cycling: never cyclists (n=434), continuing cyclists (n= 29), former cyclists (n=33, who bicycled in 2012 but not 2013), and new cyclists (n=40, who bicycled in 2013 but not 2012)...
September 2016: Journal of Transport & Health
https://www.readbyqxmd.com/read/27639193/observational-study-of-compliance-with-queensland-bicycle-helmet-laws
#20
Ashim Kumar Debnath, Narelle Haworth, Amy Schramm, Amy Williamson
Mandatory bicycle helmet laws have been found to increase helmet wearing rates in Australia and internationally. However, much of the research on factors influencing compliance with the Australian helmet laws is dated or focuses on commuters and city areas only. To address this gap, video recordings of bicycle riders were undertaken at 17 sites across Queensland, Australia, representing a mixture of on- and off-road locations, speed limits and regions. Helmet status was able to be determined for 98% of riders observed...
December 2016: Accident; Analysis and Prevention
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