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Liyun Ji, Jian-Hong Wu, Qun Luo, Xianchan Li, Wei Zheng, Guijin Zhai, Fuyi Wang, Shuang Lü, Yu-Qi Feng, Jianan Liu, Shaoxiang Xiong
We describe herein the development of a matrix-assisted laser desorption/ionization-time-of-flight-mass spectrometry (MALDI-TOF-MS) approach for screening of protein kinase inhibitors (PKIs). MS quantification of phosphopeptides, the kinase-catalyzed products of nonphosphorylated substrates, is a great challenge due to the ion suppression effect of highly abundant nonphosphorylated peptides in enzymatic reaction mixtures. To address this issue, a novel type of titania coated magnetic hollow mesoporous silica spheres (TiO(2)/MHMSS) material was fabricated for capturing phosphopeptides from the enzymatic reaction mixtures prior to MS analysis...
March 6, 2012: Analytical Chemistry
J Fonseca de Oliveira, M B Nunes de Oliveira, A S Avila, A C S Braga, M T Jansen de Almeida Catanho, R L Cavalcanti Jales, V N Cardoso, M Bernado-Filho
Natural products are widely used as food or food additives or medicines for humans. We are trying to develop a model to assess the possible toxic properties of natural products, such as Fucus vesiculosus, utilized in popular medicine. Red blood cells (RBC) labeled with technetium-99m (99mTc) are used in various procedures in nuclear medicine. This labeling procedure depends on a reducing agent, and stannous chloride is used. There is evidence that this labeling may be altered by drugs. We have investigated the possibility that F...
January 2003: Food and Chemical Toxicology
K Hamatani, M Amano
The percentages of labelled lymphocytes in smear preparations of mouse thymus were higher than those in similar preparations of mesenteric lymph nodes with either generally labelled tritiated deoxycytidine, [3H]CdR, or tritiated thymidine, [3H]TdR. Lymphocytes in the thymus cortex and in germinal centres of mesenteric lymph nodes were intensely labelled with [3H]CdR, whereas with [3H]TdR lymphocytes in the peripheral region of thymus and medullary cords of mesenteric lymph nodes were heavily labelled. The majority of lymphocytes in thymic cortex and germinal centres of mesenteric lymph nodes were labelled weakly with [3H]TdR...
July 1980: Cell and Tissue Kinetics
A D Meyers, D C Kuzela
The carbon dioxide surgical laser has become increasingly valuable in the management of various aerodigestive, gynecologic, and dermatologic problems. The histopathologic effects of laser radiation on human tissue have received only minimal attention, however. In an attempt to more precisely define the dose-response characteristics of the normal human vocal cord to carbon dioxide laser radiation, a normal larynx was exposed to varying intensities of laser radiation in situ and studied histologically. Tissue destruction varies with alterations in wattage and time exposure...
February 1980: American Journal of Otolaryngology
V A Beliakov
No abstract text is available yet for this article.
1966: Novosti Meditsinskogo Priborostroeniia
N Talal, A D Steinberg, G G Daley
The specificities of anti-RNA antibodies of diverse origin were studied by inhibition of the binding of radioative polyinosinic polycytidylic acid. The antibodies were from human patients with systemic lupus erythematosus (SLE), older NZB/NZW F(1) mice who have SLE, and young NZB/NZW F(1) mice immunized with either synthetic or viral double-stranded (ds) RNA. The inhibitors were two viral ds and two synthetic ds RNAs, ribosomal RNA and transfer RNA. The human sera were more heterogeneous than the mouse lupus sera, and had greatest specificity for reovirus RNA...
June 1971: Journal of Clinical Investigation
H H Hamm, W Seubert
The mechanism of in vitro inactivation and ATP-dependent rapid reactivation of rat liver tyrosine aminotransferase by a membrane-bound system from rat liver and kidney cortex and the nucleotide specificity of this process was investigated using partially purified tyrosine amino-transferase as a substrate. Adenosine 5'-triphosphate (ATP) could be replaced by guanosine 5'-triphosphate (GTP), Whereas inosine 5'-triphosphate (ITP) was less effective. During reactivation [gamma-32P]ATP was incorporated into the enzyme and not excorporated by incubation of the labeled enzyme with excess non-radioative ATP...
September 1977: Zeitschrift Für Naturforschung. Section C: Biosciences
A Pfeiderer, G Teufel
Enzymatically active stromal cells (EASC) in different ovarian tumors are concerned with hormon production. 198 cases of ovarian tumors were investigated by different histochemical methods. Distribution of lactate-and glucose-6-phosphate-dehydrogenase was investigated by plaimetric measurement.--EASC were found in benign ovarian tumors in 48%, in malignant in 30%. They are found exclusively in ovarian tumors and are completely absent in metastases. Incidence is dependent on histological type of tumor. With regard to untreated ovarian carcinoma containing EASC, these cells cover an aerea of 1...
1976: Österreichische Zeitschrift Für Onkologie. Austrian Journal of Oncology
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