keyword
https://read.qxmd.com/read/38457819/cost-sharing-for-oral-lenvatinib-among-commercially-insured-patients
#21
JOURNAL ARTICLE
Margaret I Liang, Ling Chen, Emeline M Aviki, Jason D Wright
OBJECTIVE: To use a nationwide pharmaceutical claims database to evaluate cost-sharing trends for commercially insured patients with cancer who were prescribed lenvatinib (Lenvima). STUDY DESIGN: IBM MarketScan databases were used to evaluate lenvatinib costs for patients with employer-based commercial insurance, and for patients 65 years and older, Medicare claims for fee-for-service plans. METHODS: Patients were included if they had least 1 outpatient pharmaceutical claim for lenvatinib paid on a noncapitated basis from 2015 to 2019...
March 2024: American Journal of Managed Care
https://read.qxmd.com/read/38452139/the-impact-of-consumer-preferences-on-the-evolution-of-competition-in-china-s-automobile-market-under-the-dual-credit-policy-a-density-game-based-perspective
#22
JOURNAL ARTICLE
Ying Xie, Jie Wu, Xiao Zhou, Yongxiang Sheng
The evolution of the automobile market is a macro-expression of the behavior of automakers' production decisions. This study examines the competitive environment between new energy vehicles (NEVs) and conventional fuel vehicles (CFVs) and develops a game-theoretical model incorporating consumer utility, automaker profit, and the competitive density of NEVs and CFVs. It aims to assess how consumers' preferences for vehicle range and smart features influence automakers' strategic decisions and the broader market evolution under the Dual Credit Policy...
2024: PloS One
https://read.qxmd.com/read/38452043/gold-price-prediction-by-a-cnn-bi-lstm-model-along-with-automatic-parameter-tuning
#23
JOURNAL ARTICLE
Amirhossein Amini, Robab Kalantari
Banking and stock markets consider gold to be an important component of their economic and financial status. There are various factors that influence the gold price trend and its fluctuations. Accurate and reliable prediction of the gold price is an essential part of financial and portfolio management. Moreover, it could provide insights about potential buy and sell points in order to prevent financial damages and reduce the risk of investment. In this paper, different architectures of deep neural network (DNN) have been proposed based on long short-term memory (LSTM) and convolutional-based neural networks (CNN) as a hybrid model, along with automatic parameter tuning to increase the accuracy, coefficient of determination, of the forecasting results...
2024: PloS One
https://read.qxmd.com/read/38447743/understanding-the-nice-severity-premium-exploring-its-implementation-and-the-implications-for-decision-making-and-patient-access
#24
JOURNAL ARTICLE
Martin W Njoroge, Matthew Walton, Robert Hodgson
OBJECTIVE: To evaluate the impact of NICE's new severity modifier, which has replaced the end-of-life (EoL) premium, on future NICE recommendations, considering past decision-making patterns. METHODS: NICE technology appraisals (TAs) published between January 2020 and December 2022 were reviewed. Summary statistics were generated to assess how the new severity modifier might impact hypothetical decision-making in historical TAs. RESULTS: A total of 138 data points were identified from 132 TAs...
March 4, 2024: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://read.qxmd.com/read/38441745/behavioral-selection-in-structured-populations
#25
JOURNAL ARTICLE
Matthias Borgstede
The multilevel model of behavioral selection (MLBS) by Borgstede and Eggert (Behav Process 186:104370. 10.1016/j.beproc.2021.104370 , 2021) provides a formal framework that integrates reinforcement learning with natural selection using an extended Price equation. However, the MLBS is so far only formulated for homogeneous populations, thereby excluding all sources of variation between individuals. This limitation is of primary theoretical concern because any application of the MLBS to real data requires to account for variation between individuals...
March 5, 2024: Theory in Biosciences
https://read.qxmd.com/read/38439068/values-challenges-and-responses-associated-with-high-priced-potential-cures-perspectives-of-diverse-stakeholders-in-south-korea
#26
JOURNAL ARTICLE
Jihyung Hong, Eun-Young Bae, Hye-Jae Lee, Tae-Jin Lee, Philip Clarke
BACKGROUND: The emergence of high-priced potential cures has sparked significant health policy discussions in South Korea, where the healthcare system is funded through a single-payer National Health Insurance model. We conducted focus group interviews (FGIs) and accompanying surveys with diverse stakeholders to comprehensively understand related issues and find better solutions to the challenges brought by these technologies. METHODS: From October to November 2022, 11 FGIs were conducted with stakeholders from various sectors, including government payers, policy and clinical experts, civic and patient organisations, and the pharmaceutical industry, involving a total of 25 participants...
March 4, 2024: Cost Effectiveness and Resource Allocation: C/E
https://read.qxmd.com/read/38438230/bioinspired-composite-packed-in-blunt-needles-integrated-microextraction-and-determination-of-oxycodone-and-naloxone-in-saliva-by-substrate-spray-mass-spectrometry
#27
JOURNAL ARTICLE
Jaime Millán-Santiago, Rafael Lucena, Soledad Cárdenas
BACKGROUND: Opioids are effective painkillers used for medical purposes. Their prolonged ingestion can provoke some side effects (including overdose or constipation) that are minimized by using opioid antagonists (e.g., naloxone). The rapid determination of opioids and their antagonists in biosamples is essential for an effective medical treatment. The direct combination of sample preparation and mass spectrometry (MS) fits well in this scenario. It can speed up the analysis achieving a good selectivity, which relies on the sample preparation and MS, and sensitivity levels...
April 8, 2024: Analytica Chimica Acta
https://read.qxmd.com/read/38434023/substitution-of-fishmeal-highlights-of-potential-plant-protein-sources-for-aquaculture-sustainability
#28
REVIEW
Syed Makhdoom Hussain, Aumme Adeeba Bano, Shafaqat Ali, Muhammad Rizwan, Muhammad Adrees, Ameer Fawad Zahoor, Pallab K Sarker, Majid Hussain, Muhammad Zubair-Ul-Hassan Arsalan, Jean Wan Hong Yong, Adan Naeem
High protein content, excellent amino acid profile, absence of anti-nutritional factors (ANFs), high digestibility and good palatability of fishmeal (FM), make it a major source of protein in aquaculture. Naturally derived FM is at risk due to an increase in its demand, unsustainable practices, and price. Thus, there is an urgent need to find affordable and suitable protein sources to replace FM. Plant protein sources are suitable due to their widespread availability and low cost. However, they contained certain ANFs, deficiency of some amino acids, low nutrient bioavailability and poor digestibility due to presence of starch and fiber...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38426435/causal-estimation-of-long-term-intervention-cost-effectiveness-using-genetic-instrumental-variables-an-application-to-cancer
#29
JOURNAL ARTICLE
Padraig Dixon, Richard M Martin, Sean Harrison
BACKGROUND: This article demonstrates a means of assessing long-term intervention cost-effectiveness in the absence of data from randomized controlled trials and without recourse to Markov simulation or similar types of cohort simulation. METHODS: Using a Mendelian randomization study design, we developed causal estimates of the genetically predicted effect of bladder, breast, colorectal, lung, multiple myeloma, ovarian, prostate, and thyroid cancers on health care costs and quality-adjusted life-years (QALYs) using outcome data drawn from the UK Biobank cohort...
March 1, 2024: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://read.qxmd.com/read/38425466/a-30-year-trend-of-dairy-consumption-and-its-determinants-among-income-groups-in-iranian-households
#30
JOURNAL ARTICLE
Roshanak Roustaee, Hassan Eini-Zinab, Delaram Ghodsi, Elham Mehrparvar Hosseini, Nasrin Omidvar, Hedayat Hosseini, Seyed Omid Hosseini Mousavi, Hamed Rafiee
INTRODUCTION: Milk and dairy products provide essential nutrients and have the potential to prevent chronic diseases, thus reducing healthcare costs. However, there is a lack of consistent and updated data on dairy consumption trends in Iran. This study aims to analyze the trends in dairy consumption among Iranian households from 1991 to 2021, focusing on household-level determinants across different expense groups. METHODS: The study uses data from the Iranian Household Expenditure and Income Survey conducted annually from 1991 to 2021 to analyze households' dairy consumption...
2024: Frontiers in Public Health
https://read.qxmd.com/read/38423618/tetracycline-removal-using-naio-4-activated-by-mnso-4-design-and-optimization-via-response-surface-methodology
#31
JOURNAL ARTICLE
Jingyi Yang, Yanjiao Gao, Tiehong Song, Jian Ye, Lihong Zhao, Rui Su
The appearance of recalcitrant organic pollutants such as antibiotics in water bodies has gained a lot of attention owing to their adverse effects on organisms and humans. The current study aims to develop a novel approach to eliminate antibiotic tetracycline (TC) from a synthetic aqueous solution based on the advanced oxidation process triggered by MnSO4 -catalyzed NaIO4 . A single-factor experiment was performed to observe the impact of pH, NaIO4 concentration, and MnSO4 dosage on TC decomposition, and a three-factor, three-level response surface experiment with TC removal rate as the dependent variable was designed based on the range of factors determined from the single-factor experiment...
February 2024: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://read.qxmd.com/read/38420469/consumer-perception-towards-electronic-products-from-recycled-components-in-the-current-geopolitical-context-a-structural-equation-modelling-approach
#32
JOURNAL ARTICLE
Daniel-Rareș Obadă, Dan-Cristian Dabija, Gheorghe-Ilie Fârte
Russia's invasion of Ukraine had a negative impact worldwide, causing a severe energy crisis that also affected EU countries, which are now involved in combating the growing energy prices while also speeding up the deployment of renewable energy sources. This armed conflict impacted the electronic components supply chain, causing high prices and disruption for different raw materials, resulting in material shortages for electronic components and affecting electronic product (EP) manufacturing. Since the start of the geopolitical crisis due to the Russo-Ukrainian War, (dis)information has been disseminated via social media, affecting users' cognition, attitudes, and behavioral intentions...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38413650/carbon-sequestration-and-credit-potential-of-gamhar-gmelina-arborea-roxb-based-agroforestry-system-for-zero-carbon-emission-of-india
#33
JOURNAL ARTICLE
Abhay Kumar, M S Malik, Swati Shabnam, Rakesh Kumar, S Karmakar, Soumitra Sankar Das, Kerobim Lakra, Indra Singh, Rikesh Kumar, Asha Kumari Sinha, Sheela Barla, Nargis Kumari, P R Oraon, Muneshwar Prasad, Wajid Hasan, Dinesh Mahto, Jeetendra Kumar
The agroforestry system is the best option to achieve the net zero carbon emissions target for India. Keeping this view, carbon sequestration and credit potential of gamhar based agroforestry system has been assessed. The experiment was carried out in randomized block design in seven different treatments with five replications. Gamhar tree biomass accumulation was higher in gamhar based agroforestry system compared to sole gamhar. Among different tree components, stem contributed a maximum to total gamhar tree biomass followed by roots, leaves and branches...
February 28, 2024: Scientific Reports
https://read.qxmd.com/read/38407343/formal-radiologist-interpretations-of-intraoperative-spine-radiographs-have-low-clinical-value
#34
JOURNAL ARTICLE
Ryan T Lin, Jonathan F Dalton, Christopher J Como, Audrey Y Chang, Melissa Yunting Tang, Anthony A Oyekan, Shaan Sadhwani, Richard A Wawrose, Joon Y Lee, Jeremy D Shaw
STUDY DESIGN: Retrospective cohort. OBJECTIVE: To evaluate the clinical relevance, usefulness, and financial implications of intraoperative radiograph interpretation by radiologists in spine surgery. SUMMARY OF BACKGROUND DATA: Due to rising healthcare costs, spine surgery is under scrutiny to maximize value-based care. Formal radiographic analysis remains a potential source of unnecessary healthcare costs, especially for intra-operative radiographs...
February 26, 2024: Spine
https://read.qxmd.com/read/38400977/energy-economic-and-environmental-3e-assessment-of-the-major-greenhouse-crops-mfca-lca-approach
#35
JOURNAL ARTICLE
Majid Dekamin, Toktamsadat Sadeghimofrad, Amir Ahmadloo
In order to develop sustainable production of greenhouse crops, the economic, energy, and environmental aspects of production should be considered. The purpose of this study was to evaluate the economic, energy, and environmental (3E) sustainability of cucumber, tomato, and bell pepper production in greenhouses by performing material flow cost accounting (MFCA) and life cycle assessment (LCA) material and methods. Calculating the economic and energy value of losses in agricultural sustainability assessment studies is not common...
February 24, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38399175/multi-attribute-decision-making-parametric-optimization-and-modeling-of-the-fdm-manufacturing-process-using-pla-wood-biocomposites
#36
JOURNAL ARTICLE
Alexandra Morvayová, Nicola Contuzzi, Laura Fabbiano, Giuseppe Casalino
The low carbon footprint, biodegradability, interesting mechanical properties, and relatively low price are considered some of the reasons for the increased interest in polylactic acid-based (PLA-based) filaments supplied with natural fillers. However, it is essential to recognize that incorporating natural fillers into virgin PLA significantly impacts the printability of the resulting blends. The complex inter-relationship between process, structure, and properties in the context of fused deposition modeling (FDM)-manufactured biocomposites is still not fully understood, which thus often results in decreased reliability of this technology in the context of biocomposites, decreased accuracy, and the increased presence of defects in the manufactured biocomposite samples...
February 17, 2024: Materials
https://read.qxmd.com/read/38398532/comparison-of-multiple-nir-spectrometers-for-detecting-low-concentration-nitrogen-based-adulteration-in-protein-powders
#37
JOURNAL ARTICLE
Matyas Lukacs, John-Lewis Zinia Zaukuu, George Bazar, Bernhard Pollner, Marietta Fodor, Zoltan Kovacs
Protein adulteration is a common fraud in the food industry due to the high price of protein sources and their limited availability. Total nitrogen determination is the standard analytical technique for quality control, which is incapable of distinguishing between protein nitrogen and nitrogen from non-protein sources. Three benchtops and one handheld near-infrared spectrometer (NIRS) with different signal processing techniques (grating, Fourier transform, and MEM-micro-electro-mechanical system) were compared with detect adulteration in protein powders at low concentration levels...
February 8, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38390793/cost-effectiveness-of-dapagliflozin-for-heart-failure-across-the-spectrum-of-ejection-fraction-an-economic-evaluation-based-on-pooled-individual-participant-data-from-the-deliver-and-dapa-hf-trials
#38
JOURNAL ARTICLE
Ankeet S Bhatt, Muthiah Vaduganathan, Brian L Claggett, Ian J Kulac, Inder S Anand, Akshay S Desai, James C Fang, Adrian F Hernandez, Pardeep S Jhund, Mikhail N Kosiborod, Marc S Sabatine, Sanjiv J Shah, Orly Vardeny, John J V McMurray, Scott D Solomon, Thomas A Gaziano
BACKGROUND: The sodium glucose cotransporter-2 inhibitors are guideline-recommended to treat heart failure across the spectrum of left ventricular ejection fraction; however, economic evaluations of adding sodium glucose cotransporter-2 inhibitors to standard of care in chronic heart failure across a broad left ventricular ejection fraction range are lacking. METHODS AND RESULTS: We conducted a US-based cost-effectiveness analysis of dapagliflozin added to standard of care in a chronic heart failure population using pooled, participant data from the DAPA-HF (Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure) and DELIVER (Dapagliflozin Evaluation to Improve the Lives of Patients With Preserved Ejection Fraction Heart Failure) trials...
February 23, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38383374/economic-evaluation-of-cemiplimab-plus-chemotherapy-regimen-for-advanced-non-small-cell-lung-cancer
#39
JOURNAL ARTICLE
Yitian Lang, Yan Lin, Meng Deng, Xiaoyan Liu
OBJECTIVE: Cemiplimab, a novel PD-1 inhibitor, exhibits significant antitumor activity against advanced non-small cell lung cancer (NSCLC). However, the cost-effectiveness of this drug for the treatment remains unclear. This study aimed to assess the cost-effectiveness of cemiplimab plus chemotherapy compared to chemotherapy for the treatment of advanced NSCLC, from the perspective of the United States payer. METHODS: A partitioned survival approach was developed to project the disease progression of NSCLC...
February 21, 2024: BMC Cancer
https://read.qxmd.com/read/38378051/pyrolysis-kinetics-and-potential-utilization-analysis-of-cereal-biomass-by-products-an-experimental-analysis-for-cleaner-energy-productions-in-india
#40
JOURNAL ARTICLE
Krishna Hara Chakravarty, Meisam Sadi, Harapriya Chakravarty, Jakob Andersen, Bobby Choudhury, Thomas James Howard, Ahmad Arabkoohsar
The optimal utilization of biomass relies heavily on the specific material and individual needs. Cereal biomass by-products can potentially be employed in thermochemical processes such as pyrolysis and gasification. To compare biomass sources, ultimate analysis, biochar potential, proximate analysis, thermal gravimetric analysis, price per megajoule generated heat, surface texture, and availability are used. A global survey of biomass wastes and opportunities for heat generation is presented in the current article...
February 18, 2024: Chemosphere
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