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https://www.readbyqxmd.com/read/29782981/cationic-starch-safe-and-economic-harvesting-flocculant-for-microalgal-biomass-and-inhibiting-e-coli-growth
#1
Mehrez E E El-Naggar, Farag A Samhan, Abeer A A Salama, Rehab M Hamdy, Gamila H Ali
Cationized starch-based flocculation processes are the subject of increasing attention because of their non-toxicity, biodegradability and relatively low price synthesized. The study aimed to evaluate the flocculability of different cationic starches using different concentrations of glycidyltrimethylammonium chloride (GTAC) with different degree of substitution (DS) ranged from 0.13 to 0.57. Cationized starch were characterized using Fourier Transform Infrared (FTIR), scanning electron microscopy (SEM) and toxicity checked using experimental animal procedure...
May 18, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29764166/chimeric-antigen-receptor-t-cells-a-savior-with-a-high-price
#2
Gilberto de Lima Lopes, George R Nahas
Chimeric antigen receptor (CAR) T cells represent a medical and scientific breakthrough that may represent a paradigm for the future of personalized medicine in the age of cancer immunotherapy. As with many new cancer agents, such novel and incredible results come with a high price. At the time of the writing of this article, there are two CAR T cells available, Kymriah, produced by Novrtis with a price tag of US$475,000 and Yescarta produced by Gilead Pharmaceuticals with a price tag of US$373,000, neither price including the required hospital admission in order to administer the agent in addition to potential treatment of side effects...
April 2018: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29754969/pathways-to-drg-based-hospital-payment-systems-in-japan-korea-and-thailand
#3
Peter Leslie Annear, Soonman Kwon, Luca Lorenzoni, Stephen Duckett, Dale Huntington, John C Langenbrunner, Yuki Murakami, Changwoo Shon, Ke Xu
Countries in Asia are working towards achieving universal health coverage while ensuring improved quality of care. One element is controlling hospital costs through payment reforms. In this paper we review experiences in using Diagnosis Related Groups (DRG) based hospital payments in three Asian countries and ask if there is an "Asian way to DRGs". We focus first on technical issues and follow with a discussion of implementation challenges and policy questions. We reviewed the literature and worked as an expert team to investigate existing documentation from Japan, Republic of Korea, and Thailand...
May 7, 2018: Health Policy
https://www.readbyqxmd.com/read/29743943/risk-sharing-agreements-present-and-future
#4
REVIEW
Francisco R Gonçalves, Susana Santos, Catarina Silva, Gabriela Sousa
Risk-sharing agreements between pharmaceutical companies and payers stand out as a recent practice, the use of which has been increasing in the case of innovative medicines, particularly in the field of oncology, which aims to ensure better budgetary control and a lower risk of spending on medicinal products without full evidence of clinical benefit. In this article, the authors discuss the types of existing agreements, as well as those used in Portugal, their advantages, disadvantages and future challenges of implementation, as well as their potential role in access to therapeutic innovation, namely medicines for cancer treatment...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29736895/cost-effectiveness-of-biological-asthma-treatments-a-systematic-review-and-recommendations-for-future-economic-evaluations
#5
REVIEW
R Brett McQueen, Danielle N Sheehan, Melanie D Whittington, Job F M van Boven, Jonathan D Campbell
BACKGROUND: Recently developed asthma biological therapies have been shown to provide relief for severe asthma patients not controlled by inhaled treatment. Given the relatively high costs of biological therapies, cost-effectiveness analyses (CEAs) may be required as a prerequisite for coverage and reimbursement. OBJECTIVE: We aimed to systematically review published literature on the economic impact of biological asthma therapies and to identify key drivers that impact cost-effectiveness in order to provide recommendations for future economic evaluations...
May 8, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29730132/a-billion-cups-the-diversity-traditional-uses-safety-issues-and-potential-of-chinese-herbal-teas
#6
REVIEW
Yao Fu, Jin-Chao Yang, Antony Balfour Cunningham, Alexandra Maria Towns, Yu Zhang, Hua-Ying Yang, Jian-Wen Li, Xue-Fei Yang
ETHNOPHARMACOLOGICAL RELEVANCE: Herbal teas have long been consumed by Chinese people for preventive and/or therapeutic healthcare. Although herbal teas are widely consumed by many cultural groups in different regions of China, no thorough review has been undertaken to assess the diversity of the country's herbal tea usage. This literature review, complemented by a quantitative survey in an important tea market in Kunming, begins to fill this knowledge gap. AIMS OF THE STUDY: The study aims to summarize the current knowledge of plant species used as herbal teas by different cultural groups in different regions of China, with a focus on the teas' perceived traditional healthcare functions, related phytochemical/pharmaceutical research, and safety issues...
May 3, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29727736/paris-in-the-spring-a-review-of-the-trade-conservation-and-opportunities-in-the-shift-from-wild-harvest-to-cultivation-of-paris-polyphylla-trilliaceae
#7
REVIEW
A B Cunningham, J A Brinckmann, Y-F Bi, S-J Pei, U Schippmann, P Luo
ETHNOPHARMACOLOGICAL RELEVANCE: P. polyphylla Smith is used in traditional medicine in China, India and Nepal and is likely to be similarly used through most of its geographic range. China is at the centre of demand for P. polyphylla where it is used as an ingredient in several very successful Chinese medicinal herbal formulations. The Chinese e-commerce platform 'alibaba.com', for example, lists 97P. polyphylla items offered by 46 Asian suppliers, of which 21 are situated in the Chinese mainland, 12 in Nepal, 7 in India, 2 in Pakistan, and 1 each in Bhutan, Hong Kong, Thailand, and Vietnam...
May 1, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29727409/how-much-will-my-child-s-operation-cost-availability-of-consumer-prices-from-us-hospitals-for-a-common-pediatric-orthopaedic-surgical-procedure
#8
Allison R Racimo, Nakul S Talathi, Nicole A Zelenski, Lawrence Wells, Apurva S Shah
BACKGROUND: Price transparency allows patients to make value-based health care decisions and is particularly important for individuals who are uninsured or enrolled in high-deductible health care plans. The availability of consumer prices for children undergoing orthopaedic surgery has not been previously investigated. We aimed to determine the availability of price estimates from hospitals in the United States for an archetypal pediatric orthopaedic surgical procedure (closed reduction and percutaneous pinning of a distal radius fracture) and identify variations in price estimates across hospitals...
May 2, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29727313/nivolumab-in-the-treatment-of-metastatic-renal-cell-carcinoma-a-cost-utility-analysis
#9
Jacques Raphael, Zhuolu Sun, Georg A Bjarnason, Joelle Helou, Beate Sander, David M Naimark
INTRODUCTION: Nivolumab improves overall survival and health-related quality of life compared with everolimus in metastatic renal cell carcinoma (mRCC). This study assesses the cost-utility of nivolumab from the Canadian health care payer perspective. MATERIALS AND METHODS: To evaluate the cost-utility of nivolumab, a Markov cohort model that incorporated data from the phase 3 CheckMate-025 trial and other sources was developed. The incremental cost per quality-adjusted life month (QALM) gained for nivolumab was calculated...
May 4, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29723630/quantitative-market-survey-of-non-woody-plants-sold-at-kariakoo-market-in-dar-es-salaam-tanzania
#10
Chantal Posthouwer, Sarina Veldman, Siri Abihudi, Joseph N Otieno, Tinde R van Andel, Hugo J de Boer
ETHNOPHARMACOLOGICAL RELEVANCE: In Tanzania, traditional medicine plays a significant role in health care and local economies based on the harvesting, trade and sale of medicinal plant products. The majority of this plant material is said to originate from wild sources, and both traditional healers and vendors are concerned about the increasing scarcity of certain species. AIM OF THE STUDY: A market survey of non-powdered, non-woody medicinal plants was conducted at Kariakoo Market in Dar es Salaam, the major hub for medicinal plant trade in Tanzania, to assess sustainability of traded herbal medicine...
April 30, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29714590/incremental-cost-effectiveness-ratio-and-net-monetary-benefit-promoting-the-application-of-value-based-pricing-to-medical-devices-a-european-perspective
#11
Andrea Messori, Sabrina Trippoli
No abstract text is available yet for this article.
January 1, 2018: Therapeutic Innovation & Regulatory Science
https://www.readbyqxmd.com/read/29710320/value-based-pricing-for-drugs-theme-and-variations
#12
Anna Kaltenboeck, Peter B Bach
No abstract text is available yet for this article.
April 30, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29705517/crossing-the-roof-of-the-world-trade-in-medicinal-plants-from-nepal-to-china
#13
Jun He, Bin Yang, Min Dong, Yunshang Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Trade in medicinal and aromatic plants (MAPs) between Nepal and China has taken place for centuries along the Tibetan border. While there is anecdotal evidence that economic development in China over the past decades, coupled with regional infrastructure development and increasing market integration, has substantially changed this trade, there are no current published studies investigating this, e.g. in terms of species and market structure. This knowledge gap impedes the development of public interventions, e...
April 26, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29705423/the-cost-benefit-of-genomic-testing-of-heifers-and-using-sexed-semen-in-pasture-based-dairy-herds
#14
J E Newton, B J Hayes, J E Pryce
Recent improvements in dairy cow fertility and female reproductive technologies offer an opportunity to apply greater selection pressure to females. This means there may be greater incentive to obtain genomic breeding values for females. We modeled the impact of changes to key parameters on the net benefit from genomic testing of heifer calves with and without usage of sexed semen. This paper builds on earlier cost-benefit studies but uses parameters relevant to pasture-based systems. A deterministic model was used to evaluate the effect on net benefit due to changes in (1) reproduction rate, (2) genomic test costs, (3) availability of parent-derived breeding values (EBVPA ), and (4) replacement rate...
April 25, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29704726/drug-policy-in-romania
#15
Ciprian-Paul Radu, Bogdan Cristian Pana, Florentina Ligia Furtunescu
OBJECTIVES: The objectives of this article were to describe the characteristics of the drug policy in Romania in the last 10 years and to present the consequences in terms of patient accessibility to drugs. METHODS: The Romanian health care system with pricing and reimbursement legislation was studied while considering the evolution of pricing and reimbursement processes, the key stakeholders, and the reasons behind changes. A critical appraisal was done covering published materials on the effects of pricing and reimbursement decisions...
April 25, 2018: Value in Health Regional Issues
https://www.readbyqxmd.com/read/29704526/a-novel-gene-expression-analytics-based-approach-to-structure-aided-design-of-rexinoids-for-development-as-next-generation-cancer-therapeutics
#16
Bentley J Hanish, Jennifer F Hackney Price, Ichiro Kaneko, Ning Ma, Arjan van der Vaart, Carl E Wagner, Peter W Jurutka, Pamela A Marshall
Rexinoids are powerful ligands that bind to retinoid-X-receptors (RXRs) and show great promise as therapeutics for a wide range of diseases, including cancer. However, only one rexinoid, bexarotene (Targretin TM) has been successfully transitioned from the bench to the clinic and used to treat cutaneous T-cell lymphoma (CTCL). Our goal is to develop novel potent rexinoids with a less untoward side effect profile than bexarotene. To this end, we have synthesized a wide array of rexinoids with EC50 values and biological activity similar to bexarotene...
April 25, 2018: Steroids
https://www.readbyqxmd.com/read/29683129/aod-distributions-and-trends-of-major-aerosol-species-over-a-selection-of-the-world-s-most-populated-cities-based-on-the-1st-version-of-nasa-s-merra-aerosol-reanalysis
#17
Simon Provençal, Pavel Kishcha, Arlindo M da Silva, Emily Elhacham, Pinhas Alpert
NASA recently extended the Modern-Era Retrospective Analysis for Research and Application (MERRA) with an atmospheric aerosol reanalysis which includes five particulate species: sulfate, organic matter, black carbon, mineral dust and sea salt. The MERRA Aerosol Reanalysis (MERRAero) is an innovative tool to study air quality issues around the world for its global and constant coverage and its distinction of aerosol speciation expressed in the form of aerosol optical depth (AOD). The purpose of this manuscript is to apply MERRAero to the study of urban air pollution at the global scale by analyzing the AOD over a period of 13 years (2003-2015) and over a selection of 200 of the world's most populated cities in order to assess the impacts of urbanization, industrialization, air quality regulations and regional transport which affect urban aerosol load...
June 2017: Urban climate
https://www.readbyqxmd.com/read/29678988/qualitative-evaluation-of-an-educational-intervention-to-reduce-medicolegal-risks-for-medical-doctors-experiencing-significantly-more-cases-than-their-peers-in-the-uk-and-ireland
#18
John Jolly, Paul Bowie, Julie Price, Matt Mason, Mark Dinwoodie
OBJECTIVES: The Medical Protection Society (MPS) is a leading protection organisation for healthcare professionals worldwide. In the UK and Ireland, a small minority of MPS members experience significantly more medicolegal cases than their peers and are invited to participate in a risk education (RE) remediation process. To understand more about this educational intervention, we sought to explore participating doctors' views of their experiences of this process and identify self-reported performance improvements and what elements of the intervention could be improved...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29677886/re-comparing-the-effects-of-reference-pricing-and-centers-of-excellence-approaches-to-value-based-benefit-design
#19
Matthew J Resnick
No abstract text is available yet for this article.
May 2018: Journal of Urology
https://www.readbyqxmd.com/read/29673910/-everyone-just-ate-good-food-good-food-in-islamabad-pakistan
#20
Saher Hasnain
In recent years, consumption of alternatively produced foods has increased in popularity in response to the deleterious effects of rapidly globalising and industrialised food systems. Concerns over food safety in relation to these changes may result from elevated levels of risk and changing perceptions associated with food production practices. This paper explores how the middle class residents of Islamabad, Pakistan, use the concept of 'good food' to reconnect themselves with nature, changing food systems, and traditional values...
April 16, 2018: Appetite
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