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Value based pricing

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https://www.readbyqxmd.com/read/28729394/body-fat-of-rats-of-different-age-groups-and-nutritional-states-assessment-by-micro-ct-and-skinfold-thickness
#1
Eva Tekus, Alexandra Miko, Nora Furedi, Ildiko Rostas, Judit Tenk, Tamas Kiss, István Szitter, Marta Balasko, Zsuzsanna Helyes, Marta Wilhelm, Erika Petervari
Obesity presents a growing public health problem. Therefore, the analysis of body composition is important in clinical practice as well as in animal research models of obesity, hence precise methods for the assessment of body fat would be essential. We aimed to evaluate in vivo abdominal micro-computed tomography scan restricted to the L1-L3 region (micro-CT(L1-L3)), a skinfold thickness-based method (STM) and post mortem body composition analysis (PMA) with regard to whole-body micro-CT scan in rats. Male Wistar rats of different age-groups (from 3 to 24 months) and nutritional states (normally fed, high-fat diet-induced obese, calorie-restricted) were used...
July 20, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28727871/biosimilars-in-oncology-in-the-united-states-a-review
#2
Chadi Nabhan, Sandeep Parsad, Anthony R Mato, Bruce A Feinberg
Importance: Biosimilars are biological medicines that contain a highly similar version of the active substance of an already approved biologic reference product. The availability of biosimilars might provide an opportunity to lower health care expenditures as a result of the inherent price competition with their reference product. Understanding how biosimilar cancer drugs are regulated, approved, and paid for, as well as their impact in a value-based care environment, is essential for physicians and other stakeholders in oncology...
July 20, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28726989/economic-selection-index-development-for-beefmaster-cattle-ii-general-purpose-breeding-objective
#3
K P Ochsner, M D MacNeil, R M Lewis, M L Spangler
An economic selection index was developed for Beefmaster cattle in a general-purpose production system in which bulls are mated to a combination of heifers and mature cows, with resulting progeny retained as replacements or sold at weaning. National average prices from 2010 to 2014 were used to establish income and expenses for the system. Genetic parameters were obtained from the literature. Economic values were estimated by simulating 100,000 animals and approximating the partial derivatives of the profit function by perturbing traits 1 at a time, by 1 unit, while holding the other traits constant at their respective means...
May 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28705241/demand-and-willingness-to-pay-for-bed-nets-in-tanzania-results-from-a-choice-experiment
#4
Chris D Gingrich, Emily Ricotta, Amos Kahwa, Catherine Kahabuka, Hannah Koenker
BACKGROUND: Universal coverage campaigns for long-lasting insecticide-treated nets do not always reach the goal of one net for every two household members, and even when ownership of at least one net per household is high, many households may not own enough nets. The retail market provides these households options for replacing or increasing the number of nets they own with products that best fit their needs since a variety of net shapes, sizes, and colours are available. Hence, it is important to understand the factors affecting private net demand...
July 14, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28693751/cost-effectiveness-of-13-valent-pneumococcal-conjugate-vaccine-pcv13-in-older-australians
#5
S Dirmesropian, J G Wood, C R MacIntyre, P Beutels, P McIntyre, R Menzies, J F Reyes, C Chen, A T Newall
BACKGROUND: The 23-valent pneumococcal polysaccharide vaccine (PPV23) has been funded under the Australia National Immunisation Program (NIP) since January 2005 for those aged >65years and other risk groups. In 2016, PCV13 was accepted by the Pharmaceutical Benefits Advisory Committee (PBAC) as a replacement for a single dose of PPV23 in older Australian adults. METHODS: A single-cohort deterministic multi-compartment (Markov) model was developed describing the transition of the population between different invasive and non-invasive pneumococcal disease related health states...
August 3, 2017: Vaccine
https://www.readbyqxmd.com/read/28692713/value-based-pricing-and-state-reform-of-prescription-drug-costs
#6
Thomas J Hwang, Aaron S Kesselheim, Ameet Sarpatwari
No abstract text is available yet for this article.
July 10, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28680424/detection-of-ophiocordyceps-sinensis-and-its-common-adulterates-using-species-specific-primers
#7
Yang Liu, Xiao-Yue Wang, Zi-Tong Gao, Jian-Ping Han, Li Xiang
Ophiocordyceps sinensis is a fungus that infects Hepialidae caterpillars, mummifying the larvae and producing characteristic fruiting bodies (stromata) that are processed into one of the most valued traditional Chinese medicines (TCM). The product commands a very high price due to a high demand but a very limited supply. Adulteration with other fungi is a common problem and there is a need to test preparation for the presence of the correct fungus. In the current study, a PCR-based approach for the identification of O...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28679327/micro-factors-bringing-the-pharmaceutical-industry-to-a-seismic-shaking-a-qualitative-research
#8
Raphaela Marie Louisa Dierks, Olivier Bruyère, Jean-Yves Reginster
INTRODUCTION: Due to changing macro and micro factors, expiring patents and falling net income, pharmaceutical companies need to rethink their vertical business model. The trend shows cross-sectorial partnerships and consolidation to remain and compete on the market. Areas covered: Quantitative research interviewing a target group of 25 key executives from small, mid and large global pharmaceutical companies rounded with qualitative literature research completing the analysis. Expert commentary: Uncertainty in the industry due to changing external factors i...
July 14, 2017: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/28676211/cost-effectiveness-analysis-of-additional-bevacizumab-to-pemetrexed-plus-cisplatin-for-malignant-pleural-mesothelioma-based-on-the-maps-trial
#9
Mei Zhan, Hanrui Zheng, Ting Xu, Yu Yang, Qiu Li
PURPOSE: Malignant pleural mesothelioma (MPM) is a rare malignancy, and pemetrexed/cisplatin (PC) is the gold standard first-line regime. This study evaluated the cost-effectiveness of the addition of bevacizumab to PC (with maintenance bevacizumab) for unresectable MPM based on a phase III trial that showed a survival benefit compared with chemotherapy alone. METHODS: To estimate the incremental cost-effectiveness ratio (ICER) of the incorporation of bevacizumab, a Markov model based on the MAPS trial, including the disease states of progression-free survival, progressive disease and death, was used...
August 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28674462/a-global-meta-analysis-of-the-value-of-ecosystem-services-provided-by%C3%A2-lakes
#10
Arnaud Reynaud, Denis Lanzanova
This study presents the first meta-analysis on the economic value of ecosystem services delivered by lakes. A worldwide data set of 699 observations drawn from 133 studies combines information reported in primary studies with geospatial data. The meta-analysis explores antagonisms and synergies between ecosystem services. This is the first meta-analysis to incorporate simultaneously external geospatial data and ecosystem service interactions. We first show that it is possible to reliably predict the value of ecosystem services provided by lakes based on their physical and geographic characteristics...
July 2017: Ecological Economics: the Journal of the International Society for Ecological Economics
https://www.readbyqxmd.com/read/28664588/welfare-wellness-and-job-satisfaction-of-chinese-physicians-a-national-survey-of-public-tertiary-hospitals-in-china
#11
Jing Sun, Jing Ma, Guangyu Hu, Qi Zhao, Changzheng Yuan, Wen Si, Xinqing Zhang, Yuanli Liu
Little national data are available on Chinese physicians' welfare, wellness, and job satisfaction. We conducted a self-administered smartphone-based national survey in early 2016 of 17 945 physicians from 136 tertiary hospitals across 31 provinces in China. In addition to collecting the physicians' basic information, we also measured 5 domains (the ethical and working environments, welfare, wellness, and job satisfaction). Half of the physicians reported a hospital-based annual income of less than RMB 72 000 ($10 300), and 60...
June 30, 2017: International Journal of Health Planning and Management
https://www.readbyqxmd.com/read/28662266/cost-effectiveness-of-regorafenib-as-second-line-therapy-for-patients-with-advanced-hepatocellular-carcinoma
#12
Neehar D Parikh, Amit G Singal, David W Hutton
BACKGROUND: Regorafenib, a multikinase inhibitor, has demonstrated prolonged survival by 2.8 months as a second-line agent in patients with hepatocellular carcinoma (HCC) who progress on sorafenib therapy. The objective of the current study was to examine the cost effectiveness of regorafenib for the treatment of HCC. METHODS: The authors constructed a Markov simulation model of patients with unresectable HCC and Child-Pugh A cirrhosis who received treatment with regorafenib versus best supportive care...
June 29, 2017: Cancer
https://www.readbyqxmd.com/read/28660473/assessing-the-value-of-biosimilars-a-review-of-the-role-of-budget-impact-analysis
#13
REVIEW
Steven Simoens, Ira Jacobs, Robert Popovian, Leah Isakov, Lesley G Shane
Biosimilar drugs are highly similar to an originator (reference) biologic, with no clinically meaningful differences in terms of safety or efficacy. As biosimilars offer the potential for lower acquisition costs versus the originator biologic, evaluating the economic implications of the introduction of biosimilars is of interest. Budget impact analysis (BIA) is a commonly used methodology. This review of published BIAs of biosimilar fusion proteins and/or monoclonal antibodies identified 12 unique publications (three full papers and nine congress posters)...
June 28, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28653363/quiet-echo-planar-imaging-for-functional-and-diffusion-mri
#14
Jana Hutter, Anthony N Price, Lucilio Cordero-Grande, Shaihan Malik, Giulio Ferrazzi, Andreia Gaspar, Emer J Hughes, Daan Christiaens, Laura McCabe, Torben Schneider, Mary A Rutherford, Joseph V Hajnal
PURPOSE: To develop a purpose-built quiet echo planar imaging capability for fetal functional and diffusion scans, for which acoustic considerations often compromise efficiency and resolution as well as angular/temporal coverage. METHODS: The gradient waveforms in multiband-accelerated single-shot echo planar imaging sequences have been redesigned to minimize spectral content. This includes a sinusoidal read-out with a single fundamental frequency, a constant phase encoding gradient, overlapping smoothed CAIPIRINHA blips, and a novel strategy to merge the crushers in diffusion MRI...
June 26, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28652243/clinical-pathways-recommendations-for-putting-patients-at-the-center-of-value-based-care
#15
Edward Abrahams, Alan Balch, Patricia Goldsmith, Marcia Kean, Amy M Miller, Gilbert Omenn, Ellen Sonet, John Sprandio, Courtney Tyne, Kimberly Westrich
Two major trends that have been affecting the provision of oncology care in the United States are a shift from volume-based to value-based care and a push toward patient-centered healthcare. However, these two trends are not always completely aligned with each other. Value-based payment models, including clinical pathways, are one strategy being implemented by oncology stakeholders to help encourage the uptake of value-based oncology care. If structured with the patient in mind, they can improve quality of care for patients with cancer, decrease inappropriate care while enabling appropriate personalization of care, and constrain rising prices by demanding a stronger link between cost and value...
June 26, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28642700/pricing-and-reimbursement-of-biosimilars-in-central-and-eastern-european-countries
#16
Paweł Kawalec, Ewa Stawowczyk, Tomas Tesar, Jana Skoupa, Adina Turcu-Stiolica, Maria Dimitrova, Guenka I Petrova, Zinta Rugaja, Agnes Männik, Andras Harsanyi, Pero Draganic
Objectives: The aim of this study was to review the requirements for the reimbursement of biosimilars and to compare the reimbursement status, market share, and reimbursement costs of biosimilars in selected Central and Eastern European (CEE) countries. Methods: A questionnaire-based survey was conducted between November 2016 and January 2017 among experts from the following CEE countries: Bulgaria, Czech Republic, Croatia, Estonia, Hungary, Latvia, Lithuania, Poland, Slovakia, and Romania. The requirements for the pricing and reimbursement of biosimilars were reviewed for each country...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28637796/quantifying-the-genetic-correlation-between-multiple-cancer-types
#17
Sara Lindström, Hilary Finucane, Brendan Bulik-Sullivan, Fredrick R Schumacher, Christopher I Amos, Rayjean J Hung, Kristin Rand, Stephen B Gruber, David Conti, Jennifer B Permuth, Hui-Yi Lin, Ellen L Goode, Thomas A Sellers, Laufey T Amundadottir, Rachael Stolzenberg-Solomon, Alison Klein, Gloria Petersen, Harvey Risch, Brian Wolpin, Li Hsu, Jeroen R Huyghe, Jenny Chang Claude, Andrew Chan, Sonja Berndt, Rosalind A Eeles, Douglas Easton, Christopher A Haiman, David J Hunter, Benjamin Neale, Alkes Price, Peter Kraft
Many cancers share specific genetic risk factors including both rare high-penetrance mutations and common single nucleotide polymorphisms (SNPs) identified through genome-wide association studies (GWAS). However, little is known about the overall shared heritability across cancers. Quantifying the extent to which two distinct cancers share genetic origin will give insights to shared biological mechanisms underlying cancer and inform design for future genetic association studies. In this study, we estimated the pair-wise genetic correlation between six cancer types (breast, colorectal, lung, ovarian, pancreatic and prostate) using cancer-specific GWAS summary statistics data based on 66,958 case and 70,665 control subjects of European ancestry...
June 21, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28628931/-the-probabilistic-efficiency-frontier-a-value-assessment-of-treatment-options-in-hepatitis-c
#18
Axel C Mühlbacher, Andrew Sadler
Background The German Institute for Quality and Efficiency in Health Care (IQWiG) recommends the concept of the efficiency frontier to assess health care interventions. The efficiency frontier supports regulatory decisions on reimbursement prices for the appropriate allocation of health care resources. Until today this cost-benefit assessment framework has only been applied on the basis of individual patient-relevant endpoints. This contradicts the reality of a multi-dimensional patient benefit. Objective The objective of this study was to illustrate the operationalization of multi-dimensional benefit considering the uncertainty in clinical effects and preference data in order to calculate the efficiency of different treatment options for hepatitis C (HCV)...
June 19, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/28628853/willingness-to-pay-for-opioid-agonist-treatment-among-opioid-dependent-people-who-inject-drugs-in-ukraine
#19
Iuliia Makarenko, Alyona Mazhnaya, Ruthanne Marcus, Martha J Bojko, Lynn Madden, Sergii Filippovich, Sergii Dvoriak, Frederick L Altice
BACKGROUND: In the context of decreasing external and limited Ukrainian governmental funding for opioid agonist treatments (OAT) for opioid dependent people who inject drugs in Ukraine, information on sustainable financial models is needed. METHODS: Data on 855 opioid dependent people who inject drugs (PWID) were drawn from a cross-sectional nationwide survey of 1613 PWID. They comprised 434 participants who were receiving OAT and 421 who were on OAT in the past or have never been on OAT and were interested in receiving the treatment...
July 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28620930/prospective-multimodal-imaging-assessment-of-locally-advanced-cervical-cancer-patients-administered-by-chemoradiation-followed-by-radical-surgery-the-price-prospective-imaging-of-cervical-cancer-and-neoadjuvant-treatment-study-the-role-of-ultrasound
#20
A C Testa, G Ferrandina, F Moro, T Pasciuto, M C Moruzzi, I De Blasis, F Mascilini, E Foti, R Autorino, A Collarino, B Gui, G F Zannoni, M A Gambacorta, A L Valentini, V Rufini, G Scambia
OBJECTIVE: Chemoradiation-based neoadjuvant treatment followed by radical surgery is an alternative therapeutic strategy for locally advanced cervical cancer (LACC) -stage ≥ IB2 (except of IIA1)- but ultrasound variables used to predict neoadjuvant partial response are not well defined. The goal of this study was to prospectively analyze the potential role of transvaginal ultrasound (TVUS) in early predicting pathologically assessed residual disease in a large, single-institution series of LACC patients triaged to neoadjuvant treatment followed by radical surgery...
June 16, 2017: Ultrasound in Obstetrics & Gynecology
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