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Value based pricing

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https://www.readbyqxmd.com/read/28817779/the-price-may-not-be-right-the-value-of-comparison-shopping-for-prescription-drugs
#1
Sanjay Arora, Neeraj Sood, Sophie Terp, Geoffrey Joyce
OBJECTIVES: To measure variations in drug prices across and within zip codes that may reveal simple strategies to improve patients' access to prescribed medications. STUDY DESIGN: We compared drug prices at different types of pharmacies across and within local markets. In-store prices were compared with a Web-based service providing discount coupons for prescription medications. Prices were collected for 2 generic antibiotics because most patients have limited experience with them and are less likely to know the price ranges for them...
July 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28817666/assessing-the-sustainable-development-and-intensification-potential-of-beef-cattle-production-in-sumbawa-indonesia-using-a-system-dynamics-approach
#2
Dahlanuddin, Benjamin Henderson, Kanar Dizyee, Hermansyah, Andrew Ash
The intensification of beef cattle production in dryland areas of East Indonesia has the potential to substantially raise the incomes of smallholder farmers that dominate the sector. In this study we assess the potential for intensifying beef production on Sumbawa Island, by introducing a household feedlot production system (2-20 animals) based on the Leucaena leucocephala (leucanea) tree legume as an improved source of feed. We used a system dynamics approach to model the entire value chain, accounting for herd dynamics, demand dynamics and seasonality...
2017: PloS One
https://www.readbyqxmd.com/read/28815789/cost-effectiveness-of-emergency-department-initiated-treatment-for-opioid-dependence
#3
Susan H Busch, David A Fiellin, Marek C Chawarski, Patricia H Owens, Michael V Pantalon, Kathryn Hawk, Steven L Bernstein, Patrick G O'Connor, Gail D'Onofrio
BACKGROUND AND AIMS: In a recent randomized trial, patients with opioid dependence receiving brief intervention, emergency department (ED)-initiated buprenorphine and ongoing follow-up in primary care with buprenorphine (buprenorphine) were twice as likely to be engaged in addiction treatment compared with referral to community-based treatment (referral) or brief intervention and referral (brief intervention). Our aim was to evaluate the relative cost-effectiveness of these three methods of intervening on opioid dependence in the ED...
August 16, 2017: Addiction
https://www.readbyqxmd.com/read/28812348/inhibition-of-heterogeneous-ice-nucleation-by-bioinspired-coatings-of-polyampholytes
#4
Zhiyuan He, Liuchun Zheng, Zhenqi Liu, Shenglin Jin, Chuncheng Li, Jianjun Wang
Controlling of heterogeneous ice nucleation (HIN) on foreign surfaces is of great importance for anti-ice nucleation material design. In this work, we studied the HIN behaviors on various ion-modified poly(butylene succinate) (PBS) surfaces via chain-extension reaction. Inspired by antifreeze proteins (AFPs), the PBS-based polyampholytes, containing both negative and positive charge groups on a single chain, show excellent performance of ice nucleation inhibition and freezing delay. Unlike the extremely high price and low availability of AFPs, these PBS-based polyampholytes can be commercially synthesized under mild reaction conditions...
August 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28808681/comment-on-how-will-induced-seismicity-in-oklahoma-respond-to-decreased-saltwater-injection-rates-by-c-langenbruch-and-m-d-zoback
#5
Thomas H W Goebel, Jacob I Walter, Kyle Murray, Emily E Brodsky
The state of Oklahoma has experienced an unprecedented increase in earthquake activity since 2009, likely driven by large-scale wastewater injection operations. Statewide injection rates peaked in early 2015 and steadily decreased thereafter, approximately coinciding with collapsing oil prices and regulatory action. If seismic activity is primarily driven by fluid injection, a noticeable seismogenic response to the decrease in injection rates is expected. Langenbruch and Zoback suggest that "the probability of potentially damaging larger events, should significantly decrease by the end of 2016 and approach historic levels within a few years...
August 2017: Science Advances
https://www.readbyqxmd.com/read/28803497/exploring-the-potential-value-of-improved-care-for-secondary-hyperparathyroidism-with-a-novel-calcimimetic-therapy
#6
Björn Stollenwerk, Sergio Iannazzo, Kerry Cooper, Vasily Belozeroff
AIMS: This study explored the use of a value-based pricing approach for the new calcimimetic etelcalcetide indicated for the treatment of secondary hyperparathyroidism (SHPT) in patients receiving hemodialysis. It used the US payer perspective and applied the cost-effectiveness framework. Because etelcalcetide is an intravenous therapy that can be titrated for individual patients, and because its utilization is yet to be assessed in real world settings, a range of plausible doses were estimated for etelcalcetide to define a range of prices...
August 14, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28792695/the-estimation-of-glomerular-filtration-rate-based-on-the-serum-cystatin-c-and-creatinine-values
#7
Elma Serezlija, Nafija Serdarevic, Lejla Begic
BACKGROUND: Renal insufficiency is one of the most serious renal diseases. Early diagnosis plays an essential role. Serum creatinine as a marker has had priority so far. The use of cystatin C for estimation of glomerular filtration rate has been recommended recently. There is a set of formulae which consolidates serum values of both creatinine and cystatin C. The study focuses on different formulae and their estimation for the purpose of better, faster, and more accurate diagnosis of renal insufficiency...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28790236/-1-10-phenanthroline-based-cyanine-dyes-as-fluorescent-probes-for-ribonucleic-acids-in-live-cells
#8
Vladyslava Kovalska, Marina Kuperman, Oleg Varzatskii, Dmytro Kryvorotenko, Elisa Kinski, Margot Schikora, Christina Janko, Christoph Alexiou, Sergiy Yarmoluk, Andriy Mokhir
A series of monomethine, trimethine- and styrylcyanine dyes based on a [1,10]phenanthroline moiety was synthesized, characterized and investigated as potential fluorescent probes for nucleic acids in cell free settings and in cells. The dyes were found to be weakly fluorescent in the unbound state, whereas upon the binding to dsDNA or RNA their emission intensity raised up to 50 times (for monomethine benzothiazole derivative FT1 complexed with RNA). The strongest fluorescence intensity in assemblies with dsDNA and RNA was observed for the trimethine benzothiazole derivative FT4...
August 9, 2017: Methods and Applications in Fluorescence
https://www.readbyqxmd.com/read/28780097/changes-in-animal-performance-and-profitability-of-holstein-dairy-operations-after-introduction-of-crossbreeding-with-montb%C3%A3-liarde-normande-and-scandinavian-red
#9
C Dezetter, N Bareille, D Billon, C Côrtes, C Lechartier, H Seegers
An individual-based mechanistic, stochastic, and dynamic simulation model was developed to assess economic effects resulting from changes in performance for milk yield and solid contents, reproduction, health, and replacement, induced by the introduction of crossbreeding in Holstein dairy operations. Three crossbreeding schemes, Holstein × Montbéliarde, Holstein × Montbéliarde × Normande, and Holstein × Montbéliarde × Scandinavian Red, were implemented in Holstein dairy operations and compared with Holstein pure breeding...
August 2, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28772164/multiple-criteria-decision-analysis-mcda-for-evaluating-new-medicines-in-health-technology-assessment-and-beyond-the-advance-value-framework
#10
Aris Angelis, Panos Kanavos
Escalating drug prices have catalysed the generation of numerous "value frameworks" with the aim of informing payers, clinicians and patients on the assessment and appraisal process of new medicines for the purpose of coverage and treatment selection decisions. Although this is an important step towards a more inclusive Value Based Assessment (VBA) approach, aspects of these frameworks are based on weak methodologies and could potentially result in misleading recommendations or decisions. In this paper, a Multiple Criteria Decision Analysis (MCDA) methodological process, based on Multi Attribute Value Theory (MAVT), is adopted for building a multi-criteria evaluation model...
June 20, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28763928/-economic-burden-of-stomach-cancer-in-china-during-1996-2015-a-systematic-review
#11
F Yao, C L Shi, C C Liu, L Wang, S M Song, J S Ren, C G Guo, P A Lou, M Dai, L Zhu, J F Shi
Objective: To clarify the research status of economic burden of stomach cancer in China from 1996 to 2015. Methods: Based on three electronic literature databases (China Knowledge Resource Integrated Database, Wanfang Database and PubMed), a total of 2 873, 1 244 and 84 articles published during 1996 to 2015 were found, respectively, using keywords of"cancer","neoplasms","malignant tumor","tumor","economic burden","health expenditure","cost","cost of illness", and"China". According to the inclusion and exclusion criteria, 30 literatures were included in the final analysis...
August 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28763490/conformational-risk-factors-of-brachycephalic-obstructive-airway-syndrome-boas-in-pugs-french-bulldogs-and-bulldogs
#12
Nai-Chieh Liu, Eileen L Troconis, Lajos Kalmar, David J Price, Hattie E Wright, Vicki J Adams, David R Sargan, Jane F Ladlow
Extremely brachycephalic, or short-muzzled, dog breeds such as pugs, French bulldogs, and bulldogs are prone to the conformation-related respiratory disorder-brachycephalic obstructive airway syndrome (BOAS). Affected dogs present with a wide range of clinical signs from snoring and exercise intolerance, to life-threatening events such as syncope. In this study, conformational risk factors for BOAS that could potentially aid in breeding away from BOAS were sought. Six hundred and four pugs, French bulldogs, and bulldogs were included in the study...
2017: PloS One
https://www.readbyqxmd.com/read/28753676/intraday-seasonalities-and-nonstationarity-of-trading-volume-in-financial-markets-collective-features
#13
Michelle B Graczyk, Sílvio M Duarte Queirós
Employing Random Matrix Theory and Principal Component Analysis techniques, we enlarge our work on the individual and cross-sectional intraday statistical properties of trading volume in financial markets to the study of collective intraday features of that financial observable. Our data consist of the trading volume of the Dow Jones Industrial Average Index components spanning the years between 2003 and 2014. Computing the intraday time dependent correlation matrices and their spectrum of eigenvalues, we show there is a mode ruling the collective behaviour of the trading volume of these stocks whereas the remaining eigenvalues are within the bounds established by random matrix theory, except the second largest eigenvalue which is robustly above the upper bound limit at the opening and slightly above it during the morning-afternoon transition...
2017: PloS One
https://www.readbyqxmd.com/read/28751274/a-step-forward-in-laccase-exploitation-recombinant-production-and-evaluation-of-techno-economic-feasibility-of-the-process
#14
Cinzia Pezzella, Valerio Guido Giacobelli, Vincenzo Lettera, Giuseppe Olivieri, Paola Cicatiello, Giovanni Sannia, Alessandra Piscitelli
Protein heterologous production offers viable opportunities to tailor laccase properties to specific industrial needs. The high redox potential laccase POXA1b from Pleurotus ostreatus was chosen as case study of marketable enzyme, due to its desirable properties in terms of activity/stability profile, and already assessed applicability. POXA1b was heterologously produced in Pichia pastoris by investigating the effect of inducible and constitutive expression systems on both the yield and the cost of its production...
July 24, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28742681/targeting-value-driven-quality-improvement-for-laparoscopic-cholecystectomy-in-michigan
#15
Kyle H Sheetz, Brooke Kenney, James M Dupree, Darrell A Campbell, Michael J Englesbe
OBJECTIVE: The purpose of this study was to evaluate complete episode expenditures for laparoscopic cholecystectomy, a common and lower-risk operation, to characterize novel targets for value-based quality improvement. SUMMARY BACKGROUND DATA: Despite enthusiasm for improving the overall value of surgical care, most efforts have focused on high-risk inpatient surgery. METHODS: We identified 19,213 patients undergoing elective laparoscopic cholecystectomy from 2012 to 2015 using data from Medicare and a large private payer...
July 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28738202/predicting-carbon-benefits-from-climate-smart-agriculture-high-resolution-carbon-mapping-and-uncertainty-assessment-in-el-salvador
#16
Sean Patrick Kearney, Nicholas C Coops, Kai M A Chan, Steven J Fonte, Pablo Siles, Sean M Smukler
Agroforestry management in smallholder agriculture can provide climate change mitigation and adaptation benefits and has been promoted as 'climate-smart agriculture' (CSA), yet has generally been left out of international and voluntary carbon (C) mitigation agreements. A key reason for this omission is the cost and uncertainty of monitoring C at the farm scale in heterogeneous smallholder landscapes. A largely overlooked alternative is to monitor C at more aggregated scales and develop C contracts with groups of land owners, community organizations or C aggregators working across entire landscapes (e...
July 21, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28729394/body-fat-of-rats-of-different-age-groups-and-nutritional-states-assessment-by-micro-ct-and-skinfold-thickness
#17
Eva Tekus, Alexandra Miko, Nora Furedi, Ildiko Rostas, Judit Tenk, Tamas Kiss, István Szitter, Marta Balasko, Zsuzsanna Helyes, Marta Wilhelm, Erika Petervari
Obesity presents a growing public health problem. Therefore, the analysis of body composition is important in clinical practice as well as in animal research models of obesity, hence precise methods for the assessment of body fat would be essential. We aimed to evaluate in vivo abdominal micro-computed tomography scan restricted to the L1-L3 region (micro-CT(L1-L3)), a skinfold thickness-based method (STM) and post mortem body composition analysis (PMA) with regard to whole-body micro-CT scan in rats. Male Wistar rats of different age-groups (from 3 to 24 months) and nutritional states (normally fed, high-fat diet-induced obese, calorie-restricted) were used...
July 20, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28727871/biosimilars-in-oncology-in-the-united-states-a-review
#18
Chadi Nabhan, Sandeep Parsad, Anthony R Mato, Bruce A Feinberg
Importance: Biosimilars are biological medicines that contain a highly similar version of the active substance of an already approved biologic reference product. The availability of biosimilars might provide an opportunity to lower health care expenditures as a result of the inherent price competition with their reference product. Understanding how biosimilar cancer drugs are regulated, approved, and paid for, as well as their impact in a value-based care environment, is essential for physicians and other stakeholders in oncology...
July 20, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28726989/economic-selection-index-development-for-beefmaster-cattle-ii-general-purpose-breeding-objective
#19
K P Ochsner, M D MacNeil, R M Lewis, M L Spangler
An economic selection index was developed for Beefmaster cattle in a general-purpose production system in which bulls are mated to a combination of heifers and mature cows, with resulting progeny retained as replacements or sold at weaning. National average prices from 2010 to 2014 were used to establish income and expenses for the system. Genetic parameters were obtained from the literature. Economic values were estimated by simulating 100,000 animals and approximating the partial derivatives of the profit function by perturbing traits 1 at a time, by 1 unit, while holding the other traits constant at their respective means...
May 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28705241/demand-and-willingness-to-pay-for-bed-nets-in-tanzania-results-from-a-choice-experiment
#20
Chris D Gingrich, Emily Ricotta, Amos Kahwa, Catherine Kahabuka, Hannah Koenker
BACKGROUND: Universal coverage campaigns for long-lasting insecticide-treated nets do not always reach the goal of one net for every two household members, and even when ownership of at least one net per household is high, many households may not own enough nets. The retail market provides these households options for replacing or increasing the number of nets they own with products that best fit their needs since a variety of net shapes, sizes, and colours are available. Hence, it is important to understand the factors affecting private net demand...
July 14, 2017: Malaria Journal
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