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Growth hormone deficiency

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https://www.readbyqxmd.com/read/29791869/ghrelin-and-the-heart
#1
Takeshi Tokudome, Kentaro Otani, Mikiya Miyazato, Kenji Kangawa
Ghrelin, a growth hormone-releasing peptide that was first discovered in the stomach of rats in 1999, is an endogenous ligand of growth hormone secretagogue receptor. Ghrelin exerts its potent growth hormone-releasing and orexigenic activities by binding to specific receptors in the brain. Subsequent studies showed that ghrelin participates in the regulation of diverse processes, including energy balance, body weight maintenance, and glucose and fat metabolism, and demonstrated that ghrelin is beneficial for treatment of cardiac diseases...
May 20, 2018: Peptides
https://www.readbyqxmd.com/read/29789996/prevalence-and-treatment-of-central-hypogonadism-and-hypoandrogenism-in-women-with-hypopituitarism
#2
Catharina Olivius, Kerstin Landin-Wilhelmsen, Daniel S Olsson, Gudmundur Johannsson, Åsa Tivesten
PURPOSE: Women with hypopituitarism have increased morbidity and mortality, and hypogonadism has been suggested to be a contributing mechanism. The purpose of this study was to investigate the prevalence of central hypogonadism and hypoandrogenism in women with hypopituitarism at a single Swedish center. METHODS: All consecutive women (n = 184) who commenced growth hormone (GH) replacement therapy at Sahlgrenska University Hospital in Gothenburg between 1995 and 2015 were included...
May 22, 2018: Pituitary
https://www.readbyqxmd.com/read/29771294/the-maize-lilliputian1-lil1-gene-encoding-a-brassinosteroid-cytochrome-p450-c-6-oxidase-is-involved-in-plant-growth-and-drought-response
#3
Giulia Castorina, Martina Persico, Massimo Zilio, Stefano Sangiorgio, Laura Carabelli, Gabriella Consonni
Background and Aims: Brassinosteroids (BRs) are plant hormones involved in many developmental processes as well as in plant-environment interactions. Their role was investigated in this study through the analysis of lilliputian1-1 (lil1-1), a dwarf mutant impaired in BR biosynthesis in maize (Zea mays). Methods: We isolated lil1-1 through transposon tagging in maize. The action of lil1 was investigated through morphological and genetic analysis. Moreover, by comparing lil1-1 mutant and wild-type individuals grown under drought stress, the effect of BR reduction on the response to drought stress was examined...
May 16, 2018: Annals of Botany
https://www.readbyqxmd.com/read/29767287/screening-for-comorbid-conditions-in-patients-enrolled-in-the-soda-registry-a-2-year-observational-analysis
#4
Whitney W Woodmansee, Murray B Gordon, Mark E Molitch, Adriana G Ioachimescu, Don W Carver, Beloo Mirakhur, David Cox, Roberto Salvatori
PURPOSE: This 2-year analysis assessed frequency of comorbidities and comorbidity screening in the Somatuline® (lanreotide, LAN) Depot for Acromegaly (SODA) registry. METHODS: Patient data collected included pituitary hormone deficiencies, sleep studies, echocardiograms, gallbladder sonographies, colonoscopies, and glycated hemoglobin (HbA1c) levels. Insulin-like growth factor-1 (IGF-1) and growth hormone levels in patients with (DM) and without (non-DM) diabetes mellitus were analyzed...
May 16, 2018: Endocrine
https://www.readbyqxmd.com/read/29765966/further-clinical-evidence-for-the-effect-of-igf-1-on-hair-growth-and-alopecia
#5
Ralph M Trüeb
Observations on the Laron syndrome originally offered the opportunity to explore the effect of insulin-like growth factor 1 (IGF-1) deficiency on human hair growth and differentiation. According to its expression in the dermal hair papilla, IGF-1 is likely involved in reciprocal signaling. It has been shown to affect follicular proliferation, tissue remodeling, and the hair growth cycle, as well as follicular differentiation, identifying IGF-1 signaling as an important mitogenic and morphogenetic regulator in hair follicle biology...
April 2018: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29762475/growth-hormone-secretion-patterns-in-german-landrace-dl-fetuses-and-piglets-compared-to-dl-piglets-with-inherited-1-25-dihydroxyvitamin-d3-deficiency
#6
Manfred Mielenz, Michael W Pfaffl, Christina Schlumbohm, Johein Harmeyer, Nahid Parvizi
The regulation of growth hormone (GH) release during prenatal development and during early postnatal life is not entirely clarified. In this study plasma GH concentrations in pigs with inherited pseudo vitamin D deficiency type I (PDDR-I), which regularly show growth retardation, were compared during ontogeny with unaffected pigs of the same breed (German Landrace, DL) as control. Plasma GH concentrations were measured in plasma of chronically catheterized fetuses (beginning on day 101 after mating or after artificial insemination) and in piglets (day 37 postpartum (p...
May 15, 2018: Nutrients
https://www.readbyqxmd.com/read/29760049/insulin-suppresses-the-production-of-fibroblast-growth-factor-23-fgf23
#7
Ludmilla Bär, Martina Feger, Abul Fajol, Lars-Oliver Klotz, Shufei Zeng, Florian Lang, Berthold Hocher, Michael Föller
Fibroblast growth factor 23 (FGF23) is produced by bone cells and regulates renal phosphate and vitamin D metabolism, as well as causing left ventricular hypertrophy. FGF23 deficiency results in rapid aging, whereas high plasma FGF23 levels are found in several disorders, including kidney or cardiovascular diseases. Regulators of FGF23 production include parathyroid hormone (PTH), calcitriol, dietary phosphate, and inflammation. We report that insulin and insulin-like growth factor 1 (IGF1) are negative regulators of FGF23 production...
May 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29759686/molecular-mechanisms-governing-embryonic-differentiation-of-pituitary-somatotropes
#8
REVIEW
Buffy S Ellsworth, Caitlin E Stallings
Pituitary somatotropes secrete growth hormone (GH), which is essential for normal growth and metabolism. Somatotrope defects result in GH deficiency (GHD), leading to short stature in childhood and increased cardiovascular morbidity and mortality in adulthood. Current hormone replacement therapies fail to recapitulate normal pulsatile GH secretion. Stem cell therapies could overcome this problem but are dependent on a thorough understanding of somatotrope differentiation. Although several transcription factors, signaling pathways, and hormones that regulate this process have been identified, the mechanisms of action are not well understood...
May 11, 2018: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/29758376/ethylene-signaling-cross-talk-with-other-hormones-in-arabidopsis-thaliana-exposed-to-contrasting-phosphate-availability-differential-effects-in-roots-leaves-and-fruits
#9
Sergi Munné-Bosch, Bárbara Simancas, Maren Müller
Ethylene signaling plays a major role in the regulation of plant growth, but its cross-talk with other phytohormones is still poorly understood. Here, we investigated whether or not a defect in ethylene signaling, particularly in the ETHYLENE INSENSITIVE3 (EIN3) transcription factor, alters plant growth and influences the contents of other phytohormones. With this aim, a hormonal profiling approach using ultrahigh performance liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS) was used to unravel organ-specific responses (in roots, leaves and fruits) in the ein3-1 mutant and wild-type A...
May 4, 2018: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29755708/growth-and-endocrine-function-in-tunisian-thalassemia-major-patients
#10
Naouel Guirat Dhouib, Monia Ben Khaled, Monia Ouederni, Habib Besbes, Ridha Kouki, Fethi Mellouli, Mohamed Bejaoui
β-thalassemia major (β-TM) is among the most common hereditary disorders imposing high expenses on health-care system worldwide. The patient's survival is dependent on lifetime blood transfusion which leads to iron overload and its toxicity in various organs including endocrine glands. This article provides an overview of endocrine disorders in beta-TM patients. This single center investigation enrolled 28 β-TM patients (16 males, 12 females) regularly transfused with packed red cell since early years of life...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29754325/genome-wide-association-study-dissects-yield-components-associated-with-low-phosphorus-stress-tolerance-in-maize
#11
Cheng Xu, Hongwei Zhang, Jianhao Sun, Zifeng Guo, Cheng Zou, Wen-Xue Li, Chuanxiao Xie, Changling Huang, Ruineng Xu, Hong Liao, Jinxiang Wang, Xiaojie Xu, Shanhong Wang, Yunbi Xu
Phosphorus deficiency in soil is a worldwide constraint threatening maize production. Through a genome-wide association study, we identified molecular markers and associated candidate genes and molecular pathways for low-phosphorus stress tolerance. Phosphorus deficiency in soils will severely affect maize (Zea mays L.) growth and development, thus decreasing the final yield. Deciphering the genetic basis of yield-related traits can benefit our understanding of maize tolerance to low-phosphorus stress. However, considering that yield-related traits should be evaluated under field condition with large populations rather than under hydroponic condition at a single-plant level, searching for appropriate field experimental sites and target traits for low-phosphorus stress tolerance is still very challenging...
May 12, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/29750649/cardiac-examination-in-children-with-laron-syndrome-undergoing-mecasermin-therapy
#12
Nurdan Erol, Metin Yıldız, Ayla Güven, Ayse Yıldırım
BACKGROUND: Laron syndrome (LS), which can be defined as primary growth hormone resistance or insensitivity, is a rare genetic disease inherited by an autosomal recessive trait. Although it is undistinguishable from growth hormone deficiency, LS has high levels of growth hormone, but insulin-like growth factor (IGF-1) cannot be synthesized. Mecasermin treatment is the only option for the patients who suffer from LS. This study aims to research cardiac findings of children with LS, who receive treatment with mecasermin...
May 11, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29748174/pituitary-dysfunction-and-association-with-fatigue-in-stroke-and-other-acute-brain-injury
#13
Heleen A Booij, Wietse D C Gaykema, Kamiel A J Kuijpers, Marie-José M Pouwels, Heleen M den Hertog
BACKGROUND: Poststroke fatigue (PSF) is a highly prevalent and debilitating condition. However, the etiology remains incompletely understood. Literature suggests the co-prevalence of pituitary dysfunction (PD) with stroke, and the question raises whether this could be a contributing factor to the development of PSF. This study reviews the prevalence of PD after stroke and other acquired brain injuries and its association with fatigue. SUMMARY: We performed a bibliographic literature search of MEDLINE and Embase databases for English language studies on PD in adult patients with stroke, traumatic brain injury (TBI) or aneurysmatic subarachnoid hemorrhage (aSAH)...
May 10, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29746309/the-current-state-of-long-acting-growth-hormone-preparations-for-growth-hormone-therapy
#14
Kevin C J Yuen, Bradley S Miller, Beverly M K Biller
PURPOSE OF REVIEW: To discuss the rationale of developing long-acting growth hormone (LAGH) preparations, to describe the technologies designed to prolong GH action, and to address key issues regarding efficacy, safety, and monitoring while on treatment. REVIEW FINDINGS: Recombinant human GH is currently approved for daily use and has been shown to restore longitudinal growth, and improve body composition with relatively few side-effects in children and adults with GH deficiency, respectively...
May 4, 2018: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/29741640/rankl-rank-pathway-and-its-inhibitor-rank-fc-in-uterine-leiomyoma-growth
#15
Deborah E Ikhena, Shimeng Liu, Stacy Kujawa, Ecem Esencan, John S Coon, Jared Robins, Serdar E Bulun, Ping Yin
Context: Uterine leiomyomas are the most common type of gynecologic tumor in women. Objective: To determine the role of the cytokine receptor activator of nuclear factor κ-Β ligand (RANKL); its receptor, receptor activator of nuclear factor κ-Β (RANK); and the RANKL/RANK pathway inhibitor RANK-Fc in leiomyoma growth. Design: Messenger RNA (mRNA) or protein levels of RANKL, RANK, and proliferation markers cyclin D1 and Ki67 were assessed in various leiomyoma tissues and cell populations...
May 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29740400/the-role-of-kcnq1-mutations-and-maternal-beta-blocker-use-during-pregnancy-in-the-growth-of-children-with-long-qt-syndrome
#16
Heta Huttunen, Matti Hero, Mitja Lääperi, Johanna Känsäkoski, Heikki Swan, Joel A Hirsch, Päivi J Miettinen, Taneli Raivio
Objective: Two missense mutations in KCNQ1 , an imprinted gene that encodes the alpha subunit of the voltage-gated potassium channel Kv7.1, cause autosomal dominant growth hormone deficiency and maternally inherited gingival fibromatosis. We evaluated endocrine features, birth size, and subsequent somatic growth of patients with long QT syndrome 1 (LQT1) due to loss-of-function mutations in KCNQ1 . Design: Medical records of 104 patients with LQT1 in a single tertiary care center between 1995 and 2015 were retrospectively reviewed...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29739731/evaluation-of-the-efficacy-of-long-term-growth-hormone-theraphy-in-patients-with-hypochondroplas%C3%A4-a
#17
Tuğba Çetin, Zeynep Şıklar, Pınar Kocaay, Merih Berberoğlu
Hypochondroplasia is a cause of disproportionate short stature and characterized by slight clinical manifestations. The aim of this study was to evaluate the efficacy of long-term GH therapy in hypochondroplastic cases with inadequate response to GH simulation tests . In this study, six patients who had height SDS of -3.43 before the treatment and a mean age of 7.42 and received GH treatment at a dose of 0.2 mg / kg / week for a mean of 4.45 years were evaluated. As a result, a good accepted response was found in the first year in hypochondroplastic patients with findings of GH deficiency, but this increase was not found to be sufficient in the patients who achieved the final height...
May 9, 2018: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29739044/diagnostic-usefulness-of-insulin-like-growth-factor-1-and-insulin-like-growth-factor-binding-protein-3-in-children-with-suspected-pituitary-dwarfism
#18
Beata Zelazowska-Rutkowska, Marta Trusiak, Artur Bossowski, Bogdan Cylwik
BACKGROUND: Pituitary dwarfism (also known as short stature) is a medical condition in which the pituitary gland does not produce enough growth hormone (GH). To confirm the diagnosis of growth hormone deficiency the overnight profile of GH secretion and GH provocative tests are usually performed; however, due to wide GH fluctuations throughout the day and night and the invasiveness of stimulation tests, their clinical utility is limited. Therefore, screening for IGF-1 (insulin-like growth factor 1) and IGFBP-3 (insulin-like growth factor binding protein type 3) is proposed, suggesting that these tests provide a more accurate reflection of the mean plasma GH level, although the results of these tests are still problematic...
May 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29737268/evaluation-and-management-of-the-child-with-hypothyroidism
#19
Alexander A C Leung, Alexander K C Leung
BACKGROUND: Thyroid hormones are critical for early neurocognitive development as well as growth and development throughout childhood. Prompt recognition and treatment of hypothyroidism is therefore of utmost importance to optimize physical and neurodevelopmental outcomes. OBJECTIVE: To review in depth the evaluation, diagnosis, and treatment of hypothyroidism in children. METHODS: A PubMed search was completed in Clinical Queries using the key term "hypothyroidism"...
May 8, 2018: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
https://www.readbyqxmd.com/read/29736148/the-pre-treatment-characteristics-and-evaluation-of-the-effects-of-recombinant-human-growth-hormone-therapy-in-children-with-growth-hormone-deficiency-and-celiac-disease-or-inflammatory-bowel-disease
#20
Ewelina Witkowska-Sędek, Dominika Labochka, Anna Majcher, Beata Pyrżak
The aim of the study: was to investigate the coincidence of growth hormone deficiency (GHD) and celiac disease (CD) or inflammatory bowel disease (IBD) in patients referred for short stature, and to evaluate the baseline anthropometric parameters and the effectiveness of recombinant human growth hormone (rhGH) therapy in the first year in those patients (GHD+CD/IBD subgroup) in comparison to patients with GHD without CD or IBD (GHD-CD/IBD subgroup). Material and methods: The study was retrospective and included 2196 short patients (height SDS [Standard Deviation Score] ≤ -1...
2018: Central-European Journal of Immunology
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