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JOURNAL ARTICLE
Kevin I Manage, Alicia K Rogers, Dylan C Wallis, Celja J Uebel, Dorian C Anderson, Dieu An H Nguyen, Katerina Arca, Kristen C Brown, Ricardo J Cordeiro Rodrigues, Bruno Fm de Albuquerque, René F Ketting, Taiowa A Montgomery, Carolyn Marie Phillips
piRNAs play a critical role in the regulation of transposons and other germline genes. In Caenorhabditis elegans , regulation of piRNA target genes is mediated by the mutator complex, which synthesizes high levels of siRNAs through the activity of an RNA-dependent RNA polymerase. However, the steps between mRNA recognition by the piRNA pathway and siRNA amplification by the mutator complex are unknown. Here, we identify the Tudor domain protein, SIMR-1, as acting downstream of piRNA production and upstream of mutator complex-dependent siRNA biogenesis...
April 27, 2020: ELife
#22
JOURNAL ARTICLE
Jens Kattge, Gerhard Bönisch, Sandra Díaz, Sandra Lavorel, Iain Colin Prentice, Paul Leadley, Susanne Tautenhahn, Gijsbert D A Werner, Tuomas Aakala, Mehdi Abedi, Alicia T R Acosta, George C Adamidis, Kairi Adamson, Masahiro Aiba, Cécile H Albert, Julio M Alcántara, Carolina Alcázar C, Izabela Aleixo, Hamada Ali, Bernard Amiaud, Christian Ammer, Mariano M Amoroso, Madhur Anand, Carolyn Anderson, Niels Anten, Joseph Antos, Deborah Mattos Guimarães Apgaua, Tia-Lynn Ashman, Degi Harja Asmara, Gregory P Asner, Michael Aspinwall, Owen Atkin, Isabelle Aubin, Lars Baastrup-Spohr, Khadijeh Bahalkeh, Michael Bahn, Timothy Baker, William J Baker, Jan P Bakker, Dennis Baldocchi, Jennifer Baltzer, Arindam Banerjee, Anne Baranger, Jos Barlow, Diego R Barneche, Zdravko Baruch, Denis Bastianelli, John Battles, William Bauerle, Marijn Bauters, Erika Bazzato, Michael Beckmann, Hans Beeckman, Carl Beierkuhnlein, Renee Bekker, Gavin Belfry, Michael Belluau, Mirela Beloiu, Raquel Benavides, Lahcen Benomar, Mary Lee Berdugo-Lattke, Erika Berenguer, Rodrigo Bergamin, Joana Bergmann, Marcos Bergmann Carlucci, Logan Berner, Markus Bernhardt-Römermann, Christof Bigler, Anne D Bjorkman, Chris Blackman, Carolina Blanco, Benjamin Blonder, Dana Blumenthal, Kelly T Bocanegra-González, Pascal Boeckx, Stephanie Bohlman, Katrin Böhning-Gaese, Laura Boisvert-Marsh, William Bond, Ben Bond-Lamberty, Arnoud Boom, Coline C F Boonman, Kauane Bordin, Elizabeth H Boughton, Vanessa Boukili, David M J S Bowman, Sandra Bravo, Marco Richard Brendel, Martin R Broadley, Kerry A Brown, Helge Bruelheide, Federico Brumnich, Hans Henrik Bruun, David Bruy, Serra W Buchanan, Solveig Franziska Bucher, Nina Buchmann, Robert Buitenwerf, Daniel E Bunker, Jana Bürger, Sabina Burrascano, David F R P Burslem, Bradley J Butterfield, Chaeho Byun, Marcia Marques, Marina C Scalon, Marco Caccianiga, Marc Cadotte, Maxime Cailleret, James Camac, Jesús Julio Camarero, Courtney Campany, Giandiego Campetella, Juan Antonio Campos, Laura Cano-Arboleda, Roberto Canullo, Michele Carbognani, Fabio Carvalho, Fernando Casanoves, Bastien Castagneyrol, Jane A Catford, Jeannine Cavender-Bares, Bruno E L Cerabolini, Marco Cervellini, Eduardo Chacón-Madrigal, Kenneth Chapin, F Stuart Chapin, Stefano Chelli, Si-Chong Chen, Anping Chen, Paolo Cherubini, Francesco Chianucci, Brendan Choat, Kyong-Sook Chung, Milan Chytrý, Daniela Ciccarelli, Lluís Coll, Courtney G Collins, Luisa Conti, David Coomes, Johannes H C Cornelissen, William K Cornwell, Piermaria Corona, Marie Coyea, Joseph Craine, Dylan Craven, Joris P G M Cromsigt, Anikó Csecserits, Katarina Cufar, Matthias Cuntz, Ana Carolina da Silva, Kyla M Dahlin, Matteo Dainese, Igor Dalke, Michele Dalle Fratte, Anh Tuan Dang-Le, Jirí Danihelka, Masako Dannoura, Samantha Dawson, Arend Jacobus de Beer, Angel De Frutos, Jonathan R De Long, Benjamin Dechant, Sylvain Delagrange, Nicolas Delpierre, Géraldine Derroire, Arildo S Dias, Milton Hugo Diaz-Toribio, Panayiotis G Dimitrakopoulos, Mark Dobrowolski, Daniel Doktor, Pavel Dřevojan, Ning Dong, John Dransfield, Stefan Dressler, Leandro Duarte, Emilie Ducouret, Stefan Dullinger, Walter Durka, Remko Duursma, Olga Dymova, Anna E-Vojtkó, Rolf Lutz Eckstein, Hamid Ejtehadi, James Elser, Thaise Emilio, Kristine Engemann, Mohammad Bagher Erfanian, Alexandra Erfmeier, Adriane Esquivel-Muelbert, Gerd Esser, Marc Estiarte, Tomas F Domingues, William F Fagan, Jaime Fagúndez, Daniel S Falster, Ying Fan, Jingyun Fang, Emmanuele Farris, Fatih Fazlioglu, Yanhao Feng, Fernando Fernandez-Mendez, Carlotta Ferrara, Joice Ferreira, Alessandra Fidelis, Bryan Finegan, Jennifer Firn, Timothy J Flowers, Dan F B Flynn, Veronika Fontana, Estelle Forey, Cristiane Forgiarini, Louis François, Marcelo Frangipani, Dorothea Frank, Cedric Frenette-Dussault, Grégoire T Freschet, Ellen L Fry, Nikolaos M Fyllas, Guilherme G Mazzochini, Sophie Gachet, Rachael Gallagher, Gislene Ganade, Francesca Ganga, Pablo García-Palacios, Verónica Gargaglione, Eric Garnier, Jose Luis Garrido, André Luís de Gasper, Guillermo Gea-Izquierdo, David Gibson, Andrew N Gillison, Aelton Giroldo, Mary-Claire Glasenhardt, Sean Gleason, Mariana Gliesch, Emma Goldberg, Bastian Göldel, Erika Gonzalez-Akre, Jose L Gonzalez-Andujar, Andrés González-Melo, Ana González-Robles, Bente Jessen Graae, Elena Granda, Sarah Graves, Walton A Green, Thomas Gregor, Nicolas Gross, Greg R Guerin, Angela Günther, Alvaro G Gutiérrez, Lillie Haddock, Anna Haines, Jefferson Hall, Alain Hambuckers, Wenxuan Han, Sandy P Harrison, Wesley Hattingh, Joseph E Hawes, Tianhua He, Pengcheng He, Jacob Mason Heberling, Aveliina Helm, Stefan Hempel, Jörn Hentschel, Bruno Hérault, Ana-Maria Hereş, Katharina Herz, Myriam Heuertz, Thomas Hickler, Peter Hietz, Pedro Higuchi, Andrew L Hipp, Andrew Hirons, Maria Hock, James Aaron Hogan, Karen Holl, Olivier Honnay, Daniel Hornstein, Enqing Hou, Nate Hough-Snee, Knut Anders Hovstad, Tomoaki Ichie, Boris Igić, Estela Illa, Marney Isaac, Masae Ishihara, Leonid Ivanov, Larissa Ivanova, Colleen M Iversen, Jordi Izquierdo, Robert B Jackson, Benjamin Jackson, Hervé Jactel, Andrzej M Jagodzinski, Ute Jandt, Steven Jansen, Thomas Jenkins, Anke Jentsch, Jens Rasmus Plantener Jespersen, Guo-Feng Jiang, Jesper Liengaard Johansen, David Johnson, Eric J Jokela, Carlos Alfredo Joly, Gregory J Jordan, Grant Stuart Joseph, Decky Junaedi, Robert R Junker, Eric Justes, Richard Kabzems, Jeffrey Kane, Zdenek Kaplan, Teja Kattenborn, Lyudmila Kavelenova, Elizabeth Kearsley, Anne Kempel, Tanaka Kenzo, Andrew Kerkhoff, Mohammed I Khalil, Nicole L Kinlock, Wilm Daniel Kissling, Kaoru Kitajima, Thomas Kitzberger, Rasmus Kjøller, Tamir Klein, Michael Kleyer, Jitka Klimešová, Joice Klipel, Brian Kloeppel, Stefan Klotz, Johannes M H Knops, Takashi Kohyama, Fumito Koike, Johannes Kollmann, Benjamin Komac, Kimberly Komatsu, Christian König, Nathan J B Kraft, Koen Kramer, Holger Kreft, Ingolf Kühn, Dushan Kumarathunge, Jonas Kuppler, Hiroko Kurokawa, Yoko Kurosawa, Shem Kuyah, Jean-Paul Laclau, Benoit Lafleur, Erik Lallai, Eric Lamb, Andrea Lamprecht, Daniel J Larkin, Daniel Laughlin, Yoann Le Bagousse-Pinguet, Guerric le Maire, Peter C le Roux, Elizabeth le Roux, Tali Lee, Frederic Lens, Simon L Lewis, Barbara Lhotsky, Yuanzhi Li, Xine Li, Jeremy W Lichstein, Mario Liebergesell, Jun Ying Lim, Yan-Shih Lin, Juan Carlos Linares, Chunjiang Liu, Daijun Liu, Udayangani Liu, Stuart Livingstone, Joan Llusià, Madelon Lohbeck, Álvaro López-García, Gabriela Lopez-Gonzalez, Zdeňka Lososová, Frédérique Louault, Balázs A Lukács, Petr Lukeš, Yunjian Luo, Michele Lussu, Siyan Ma, Camilla Maciel Rabelo Pereira, Michelle Mack, Vincent Maire, Annikki Mäkelä, Harri Mäkinen, Ana Claudia Mendes Malhado, Azim Mallik, Peter Manning, Stefano Manzoni, Zuleica Marchetti, Luca Marchino, Vinicius Marcilio-Silva, Eric Marcon, Michela Marignani, Lars Markesteijn, Adam Martin, Cristina Martínez-Garza, Jordi Martínez-Vilalta, Tereza Mašková, Kelly Mason, Norman Mason, Tara Joy Massad, Jacynthe Masse, Itay Mayrose, James McCarthy, M Luke McCormack, Katherine McCulloh, Ian R McFadden, Brian J McGill, Mara Y McPartland, Juliana S Medeiros, Belinda Medlyn, Pierre Meerts, Zia Mehrabi, Patrick Meir, Felipe P L Melo, Maurizio Mencuccini, Céline Meredieu, Julie Messier, Ilona Mészáros, Juha Metsaranta, Sean T Michaletz, Chrysanthi Michelaki, Svetlana Migalina, Ruben Milla, Jesse E D Miller, Vanessa Minden, Ray Ming, Karel Mokany, Angela T Moles, Attila Molnár, Jane Molofsky, Martin Molz, Rebecca A Montgomery, Arnaud Monty, Lenka Moravcová, Alvaro Moreno-Martínez, Marco Moretti, Akira S Mori, Shigeta Mori, Dave Morris, Jane Morrison, Ladislav Mucina, Sandra Mueller, Christopher D Muir, Sandra Cristina Müller, François Munoz, Isla H Myers-Smith, Randall W Myster, Masahiro Nagano, Shawna Naidu, Ayyappan Narayanan, Balachandran Natesan, Luka Negoita, Andrew S Nelson, Eike Lena Neuschulz, Jian Ni, Georg Niedrist, Jhon Nieto, Ülo Niinemets, Rachael Nolan, Henning Nottebrock, Yann Nouvellon, Alexander Novakovskiy, Kristin Odden Nystuen, Anthony O'Grady, Kevin O'Hara, Andrew O'Reilly-Nugent, Simon Oakley, Walter Oberhuber, Toshiyuki Ohtsuka, Ricardo Oliveira, Kinga Öllerer, Mark E Olson, Vladimir Onipchenko, Yusuke Onoda, Renske E Onstein, Jenny C Ordonez, Noriyuki Osada, Ivika Ostonen, Gianluigi Ottaviani, Sarah Otto, Gerhard E Overbeck, Wim A Ozinga, Anna T Pahl, C E Timothy Paine, Robin J Pakeman, Aristotelis C Papageorgiou, Evgeniya Parfionova, Meelis Pärtel, Marco Patacca, Susana Paula, Juraj Paule, Harald Pauli, Juli G Pausas, Begoña Peco, Josep Penuelas, Antonio Perea, Pablo Luis Peri, Ana Carolina Petisco-Souza, Alessandro Petraglia, Any Mary Petritan, Oliver L Phillips, Simon Pierce, Valério D Pillar, Jan Pisek, Alexandr Pomogaybin, Hendrik Poorter, Angelika Portsmuth, Peter Poschlod, Catherine Potvin, Devon Pounds, A Shafer Powell, Sally A Power, Andreas Prinzing, Giacomo Puglielli, Petr Pyšek, Valerie Raevel, Anja Rammig, Johannes Ransijn, Courtenay A Ray, Peter B Reich, Markus Reichstein, Douglas E B Reid, Maxime Réjou-Méchain, Victor Resco de Dios, Sabina Ribeiro, Sarah Richardson, Kersti Riibak, Matthias C Rillig, Fiamma Riviera, Elisabeth M R Robert, Scott Roberts, Bjorn Robroek, Adam Roddy, Arthur Vinicius Rodrigues, Alistair Rogers, Emily Rollinson, Victor Rolo, Christine Römermann, Dina Ronzhina, Christiane Roscher, Julieta A Rosell, Milena Fermina Rosenfield, Christian Rossi, David B Roy, Samuel Royer-Tardif, Nadja Rüger, Ricardo Ruiz-Peinado, Sabine B Rumpf, Graciela M Rusch, Masahiro Ryo, Lawren Sack, Angela Saldaña, Beatriz Salgado-Negret, Roberto Salguero-Gomez, Ignacio Santa-Regina, Ana Carolina Santacruz-García, Joaquim Santos, Jordi Sardans, Brandon Schamp, Michael Scherer-Lorenzen, Matthias Schleuning, Bernhard Schmid, Marco Schmidt, Sylvain Schmitt, Julio V Schneider, Simon D Schowanek, Julian Schrader, Franziska Schrodt, Bernhard Schuldt, Frank Schurr, Galia Selaya Garvizu, Marina Semchenko, Colleen Seymour, Julia C Sfair, Joanne M Sharpe, Christine S Sheppard, Serge Sheremetiev, Satomi Shiodera, Bill Shipley, Tanvir Ahmed Shovon, Alrun Siebenkäs, Carlos Sierra, Vasco Silva, Mateus Silva, Tommaso Sitzia, Henrik Sjöman, Martijn Slot, Nicholas G Smith, Darwin Sodhi, Pamela Soltis, Douglas Soltis, Ben Somers, Grégory Sonnier, Mia Vedel Sørensen, Enio Egon Sosinski, Nadejda A Soudzilovskaia, Alexandre F Souza, Marko Spasojevic, Marta Gaia Sperandii, Amanda B Stan, James Stegen, Klaus Steinbauer, Jörg G Stephan, Frank Sterck, Dejan B Stojanovic, Tanya Strydom, Maria Laura Suarez, Jens-Christian Svenning, Ivana Svitková, Marek Svitok, Miroslav Svoboda, Emily Swaine, Nathan Swenson, Marcelo Tabarelli, Kentaro Takagi, Ulrike Tappeiner, Rubén Tarifa, Simon Tauugourdeau, Cagatay Tavsanoglu, Mariska Te Beest, Leho Tedersoo, Nelson Thiffault, Dominik Thom, Evert Thomas, Ken Thompson, Peter E Thornton, Wilfried Thuiller, Lubomír Tichý, David Tissue, Mark G Tjoelker, David Yue Phin Tng, Joseph Tobias, Péter Török, Tonantzin Tarin, José M Torres-Ruiz, Béla Tóthmérész, Martina Treurnicht, Valeria Trivellone, Franck Trolliet, Volodymyr Trotsiuk, James L Tsakalos, Ioannis Tsiripidis, Niklas Tysklind, Toru Umehara, Vladimir Usoltsev, Matthew Vadeboncoeur, Jamil Vaezi, Fernando Valladares, Jana Vamosi, Peter M van Bodegom, Michiel van Breugel, Elisa Van Cleemput, Martine van de Weg, Stephni van der Merwe, Fons van der Plas, Masha T van der Sande, Mark van Kleunen, Koenraad Van Meerbeek, Mark Vanderwel, Kim André Vanselow, Angelica Vårhammar, Laura Varone, Maribel Yesenia Vasquez Valderrama, Kiril Vassilev, Mark Vellend, Erik J Veneklaas, Hans Verbeeck, Kris Verheyen, Alexander Vibrans, Ima Vieira, Jaime Villacís, Cyrille Violle, Pandi Vivek, Katrin Wagner, Matthew Waldram, Anthony Waldron, Anthony P Walker, Martyn Waller, Gabriel Walther, Han Wang, Feng Wang, Weiqi Wang, Harry Watkins, James Watkins, Ulrich Weber, James T Weedon, Liping Wei, Patrick Weigelt, Evan Weiher, Aidan W Wells, Camilla Wellstein, Elizabeth Wenk, Mark Westoby, Alana Westwood, Philip John White, Mark Whitten, Mathew Williams, Daniel E Winkler, Klaus Winter, Chevonne Womack, Ian J Wright, S Joseph Wright, Justin Wright, Bruno X Pinho, Fabiano Ximenes, Toshihiro Yamada, Keiko Yamaji, Ruth Yanai, Nikolay Yankov, Benjamin Yguel, Kátia Janaina Zanini, Amy E Zanne, David Zelený, Yun-Peng Zhao, Jingming Zheng, Ji Zheng, Kasia Ziemińska, Chad R Zirbel, Georg Zizka, Irié Casimir Zo-Bi, Gerhard Zotz, Christian Wirth
Plant traits-the morphological, anatomical, physiological, biochemical and phenological characteristics of plants-determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling...
January 2020: Global Change Biology
#23
JOURNAL ARTICLE
Joshua M Svendsen, Kailee J Reed, Tarah Vijayasarathy, Brooke E Montgomery, Rachel M Tucci, Kristen C Brown, Taylor N Marks, Dieu An H Nguyen, Carolyn M Phillips, Taiowa A Montgomery
The germline contains an immortal cell lineage that ensures the faithful transmission of genetic and, in some instances, epigenetic information from one generation to the next. Here, we show that in Caenorhabditis elegans, the small RNA 3'-2'-O-methyltransferase henn-1/HEN1 is required for sustained fertility across generations. In the absence of henn-1, animals become progressively less fertile, becoming sterile after ∼30 generations at 25°C. Sterility in henn-1 mutants is accompanied by severe defects in germline proliferation and maintenance...
December 3, 2019: Cell Reports
#24
RANDOMIZED CONTROLLED TRIAL
Rachael L Sumner, Rebecca McMillan, Meg J Spriggs, Doug Campbell, Gemma Malpas, Elizabeth Maxwell, Carolyn Deng, John Hay, Rhys Ponton, Ian J Kirk, Frederick Sundram, Suresh D Muthukumaraswamy
BACKGROUND: The rapid-acting clinical effects of ketamine as a novel treatment for depression along with its complex pharmacology have made it a growing research area. One of the key mechanistic hypotheses for how ketamine works to alleviate depression is by enhancing long-term potentiation (LTP)-mediated neural plasticity. METHODS: The objective of this study was to investigate the plasticity hypothesis in 30 patients with depression noninvasively using visual LTP as an index of neural plasticity...
January 2020: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
#25
JOURNAL ARTICLE
Carolyne J Montgomery
No abstract text is available yet for this article.
April 23, 2019: Canadian Medical Association Journal: CMAJ
#26
JOURNAL ARTICLE
Charles H Hubscher, April N Herrity, Carolyn S Williams, Lynnette R Montgomery, Andrea M Willhite, Claudia A Angeli, Susan J Harkema
OBJECTIVE: Locomotor training (LT) as a therapeutic intervention following spinal cord injury (SCI) is an effective rehabilitation strategy for improving motor outcomes, but its impact on non-locomotor functions is unknown. Given recent results of our labs' pre-clinical animal SCI LT studies and existing overlap of lumbosacral spinal circuitries controlling pelvic-visceral and locomotor functions, we addressed whether LT can improve bladder, bowel and sexual function in humans at chronic SCI time-points (> two years post-injury)...
2018: PloS One
#27
JOURNAL ARTICLE
Kimberly McAllister, Leah E Mechanic, Christopher Amos, Hugues Aschard, Ian A Blair, Nilanjan Chatterjee, David Conti, W James Gauderman, Li Hsu, Carolyn M Hutter, Marta M Jankowska, Jacqueline Kerr, Peter Kraft, Stephen B Montgomery, Bhramar Mukherjee, George J Papanicolaou, Chirag J Patel, Marylyn D Ritchie, Beate R Ritz, Duncan C Thomas, Peng Wei, John S Witte
Recently, many new approaches, study designs, and statistical and analytical methods have emerged for studying gene-environment interactions (G×Es) in large-scale studies of human populations. There are opportunities in this field, particularly with respect to the incorporation of -omics and next-generation sequencing data and continual improvement in measures of environmental exposures implicated in complex disease outcomes. In a workshop called "Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases," held October 17-18, 2014, by the National Institute of Environmental Health Sciences and the National Cancer Institute in conjunction with the annual American Society of Human Genetics meeting, participants explored new approaches and tools that have been developed in recent years for G×E discovery...
October 1, 2017: American Journal of Epidemiology
#28
RANDOMIZED CONTROLLED TRIAL
Anthony S Emmott, Nicholas West, Guohai Zhou, Dustin Dunsmuir, Carolyne J Montgomery, Gillian R Lauder, Carl L von Baeyer
There are inadequate age-specific data to support the use of current self-report pain scales in 3- and 4-year-old children. Most preschool-aged children also lack the necessary cognitive development to use standard scales. We aimed to evaluate the validity and feasibility of 2 novel simplified scales (Simplified Faces Pain Scale, S-FPS; Simplified Concrete Ordinal Scale, S-COS) for preschool-aged children. These simplified scales used a 2-step self-report method: children were first asked whether they have pain (yes/no); only if yes, then pain intensity was self-reported using a 3-point scale with visual aids signifying mild/moderate/severe...
May 2017: Journal of Pain
#29
JOURNAL ARTICLE
Joy M Dawes, Erin M Cooke, Jacqueline A Hannam, Katherine A Brand, Pamela Winton, Ricardo Jimenez-Mendez, Katarina Aleksa, Gillian R Lauder, Bruce C Carleton, Gideon Koren, Michael J Rieder, Brian J Anderson, Carolyne J Montgomery
BACKGROUND: Oral morphine has been proposed as an effective and safe alternative to codeine for after-discharge pain in children following surgery but there are few data guiding an optimum safe oral dose. AIMS: The aim of this study was to characterize the absorption pharmacokinetics of enteral morphine in order to simulate time-concentration profiles in children given common oral morphine dose regimens. METHODS: Children (2-6 years, n = 34) undergoing elective surgery and requiring opioid analgesia were randomized to receive preoperative oral morphine (100 mcg·kg-1 , 200 mcg·kg-1 , 300 mcg·kg-1 )...
January 2017: Paediatric Anaesthesia
#30
JOURNAL ARTICLE
Carolyne Montgomery, J Mark Ansermino
No abstract text is available yet for this article.
December 2015: Canadian Journal of Anaesthesia
#31
JOURNAL ARTICLE
Matthias Görges, Simon D Whyte, Shubhayan Sanatani, Joy Dawes, Carolyne J Montgomery, J Mark Ansermino
BACKGROUND: Clinical indications for the perioperative use of dexmedetomidine in pediatric anesthesia are accumulating. However, in 2013, dexmedetomidine was added to the list of medications with possible risk of prolonging the QT interval and/or inducing Torsades de Pointes. Unfortunately, current evidence for dexmedetomidine-induced QT prolongation is sparse and somewhat contradictory. OBJECTIVE: The purpose of this study was to evaluate temporal changes in corrected QT interval (QTc) after a rapid bolus administration of dexmedetomidine under total intravenous anesthesia (TIVA) with a standardized propofol and remifentanil administration...
December 2015: Paediatric Anaesthesia
#32
RANDOMIZED CONTROLLED TRIAL
Terri Sun, Nicholas West, J Mark Ansermino, Carolyne J Montgomery, Dorothy Myers, Dustin Dunsmuir, Gillian R Lauder, Carl L von Baeyer
BACKGROUND: Effective pain assessment is essential during postoperative recovery. Extensive validation data are published supporting the Faces Pain Scale-Revised (FPS-R) and the Color Analog Scale (CAS) in children. Panda is a smartphone-based application containing electronic versions of these scales. OBJECTIVES: To evaluate agreement between Panda and original paper/plastic versions of the FPS-R and CAS and to determine children's preference for either Panda or original versions of these scales...
December 2015: Paediatric Anaesthesia
#33
RANDOMIZED CONTROLLED TRIAL
Nieves Velez de Mendizabal, Ricardo Jimenez-Mendez, Erin Cooke, Carolyne J Montgomery, Joy Dawes, Michael J Rieder, Katarina Aleksa, Gideon Koren, Carlos O Jacobo-Cabral, Rodrigo Gonzalez-Ramirez, Gilberto Castañeda-Hernandez, Bruce C Carleton
BACKGROUND AND OBJECTIVES: Currently, the majority of the surgical procedures performed in paediatric hospitals are done on a day care basis, with post-operative pain being managed by caregivers at home. Pain after discharge of these post-operative children has historically been managed with oral codeine in combination with paracetamol (acetaminophen). Codeine is an opioid, which elicits its analgesic effects via metabolism to morphine and codeine-6-glucuronide. Oral morphine is a feasible alternative for outpatient analgesia; however, the pharmacokinetics of morphine after oral administration have been previously described only sparsely, and there is little information in healthy children...
October 2015: Clinical Pharmacokinetics
#34
JOURNAL ARTICLE
Joy Dawes, Dorothy Myers, Matthias Görges, Guohai Zhou, J Mark Ansermino, Carolyne J Montgomery
BACKGROUND: Dexmedetomidine is a highly sensitive, specific α2 adrenoceptor agonist with anxiolytic, sedative, and analgesic effects. Administration is recommended as a loading dose infused over 10 min. Clinical experience and a previous study suggested a shorter time frame might be used without causing adverse hemodynamic effects. OBJECTIVE: To determine the dexmedetomidine dose that can be given as a rapid 5 s bolus to healthy children during total intravenous anesthesia (TIVA) without causing significant hemodynamic effects...
December 2014: Paediatric Anaesthesia
#35
JOURNAL ARTICLE
Stefan K Saevarsson, Gulshan B Sharma, Heiko Ramm, Robert Lieck, Carol R Hutchison, Jason Werle, Sigrun Matthiasdottir, Spencer J Montgomery, Carolina I Romeo, Stefan Zachow, Carolyn Anglin
In the ongoing debate about gender-specific (GS) vs. traditional knee implants, there is limited information about patella-specific outcomes. GS femoral component features should provide better patellar tracking, but techniques have not existed previously to test this accurately. Using novel computed tomography and radiography imaging protocols, 15 GS knees were compared to 10 traditional knees, for the 6 degrees of freedom of the patellofemoral and tibiofemoral joints throughout the range of motion, plus other geometric measures and quality of life (QOL)...
October 2013: Journal of Arthroplasty
#36
RANDOMIZED CONTROLLED TRIAL
John R Chandler, Dorothy Myers, Disha Mehta, Emma Whyte, Michelle K Groberman, Carolyne J Montgomery, J Mark Ansermino
BACKGROUND: Emergence delirium (ED) refers to a variety of behavioral disturbances commonly seen in children following emergence from anesthesia. Vapor-based anesthesia with sevoflurane, the most common pediatric anesthetic technique, is associated with the highest incidence of ED. Propofol has been shown to reduce ED, but these studies have been methodologically limited. OBJECTIVE: To conduct a randomized-controlled trial comparing the incidence of ED in children following sevoflurane (SEVO) anesthesia and propofol-remifentanil total intravenous anesthesia (TIVA)...
April 2013: Paediatric Anaesthesia
#37
MULTICENTER STUDY
Laura J Esserman, Donald A Berry, Angela DeMichele, Lisa Carey, Sarah E Davis, Meredith Buxton, Cliff Hudis, Joe W Gray, Charles Perou, Christina Yau, Chad Livasy, Helen Krontiras, Leslie Montgomery, Debasish Tripathy, Constance Lehman, Minetta C Liu, Olufunmilayo I Olopade, Hope S Rugo, John T Carpenter, Lynn Dressler, David Chhieng, Baljit Singh, Carolyn Mies, Joseph Rabban, Yunn-Yi Chen, Dilip Giri, Laura van 't Veer, Nola Hylton
PURPOSE: Neoadjuvant chemotherapy for breast cancer provides critical information about tumor response; how best to leverage this for predicting recurrence-free survival (RFS) is not established. The I-SPY 1 TRIAL (Investigation of Serial Studies to Predict Your Therapeutic Response With Imaging and Molecular Analysis) was a multicenter breast cancer study integrating clinical, imaging, and genomic data to evaluate pathologic response, RFS, and their relationship and predictability based on tumor biomarkers...
September 10, 2012: Journal of Clinical Oncology
#38
JOURNAL ARTICLE
Taiowa A Montgomery, Young-Soo Rim, Chi Zhang, Robert H Dowen, Carolyn M Phillips, Sylvia E J Fischer, Gary Ruvkun
Small RNAs--including piRNAs, miRNAs, and endogenous siRNAs--bind Argonaute proteins to form RNA silencing complexes that target coding genes, transposons, and aberrant RNAs. To assess the requirements for endogenous siRNA formation and activity in Caenorhabditis elegans, we developed a GFP-based sensor for the endogenous siRNA 22G siR-1, one of a set of abundant siRNAs processed from a precursor RNA mapping to the X chromosome, the X-cluster. Silencing of the sensor is also dependent on the partially complementary, unlinked 26G siR-O7 siRNA...
2012: PLoS Genetics
#39
JOURNAL ARTICLE
Laura J Esserman, Donald A Berry, Maggie C U Cheang, Christina Yau, Charles M Perou, Lisa Carey, Angela DeMichele, Joe W Gray, Kathleen Conway-Dorsey, Marc E Lenburg, Meredith B Buxton, Sarah E Davis, Laura J van't Veer, Clifford Hudis, Koei Chin, Denise Wolf, Helen Krontiras, Leslie Montgomery, Debu Tripathy, Constance Lehman, Minetta C Liu, Olufunmilayo I Olopade, Hope S Rugo, John T Carpenter, Chad Livasy, Lynn Dressler, David Chhieng, Baljit Singh, Carolyn Mies, Joseph Rabban, Yunni-Yi Chen, Dilip Giri, Alfred Au, Nola Hylton
Neoadjuvant chemotherapy for breast cancer allows individual tumor response to be assessed depending on molecular subtype, and to judge the impact of response to therapy on recurrence-free survival (RFS). The multicenter I-SPY 1 TRIAL evaluated patients with ≥ 3 cm tumors by using early imaging and molecular signatures, with outcomes of pathologic complete response (pCR) and RFS. The current analysis was performed using data from patients who had molecular profiles and did not receive trastuzumab. The various molecular classifiers tested were highly correlated...
April 2012: Breast Cancer Research and Treatment
#40
JOURNAL ARTICLE
Chi Zhang, Taiowa A Montgomery, Harrison W Gabel, Sylvia E J Fischer, Carolyn M Phillips, Noah Fahlgren, Christopher M Sullivan, James C Carrington, Gary Ruvkun
Argonaute-associated siRNAs and Piwi-associated piRNAs have overlapping roles in silencing mobile genetic elements in animals. In Caenorhabditis elegans, mutator (mut) class genes mediate siRNA-guided repression of transposons as well as exogenous RNAi, but their roles in endogenous RNA silencing pathways are not well-understood. To characterize the endogenous small RNAs dependent on mut class genes, small RNA populations from a null allele of mut-16 as well as a regulatory mut-16(mg461) allele that disables only somatic RNAi were subjected to deep sequencing...
January 25, 2011: Proceedings of the National Academy of Sciences of the United States of America
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