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https://www.readbyqxmd.com/read/29287293/traumatic-neonatal-lumbar-punctures-experience-at-a-large-pediatric-tertiary-care-center-in-canada
#1
Adela Matettore, Tobias R Kollmann
OBJECTIVE:  Contamination of cerebrospinal fluid (CSF) by blood during neonatal lumbar puncture (LP) is common and poses diagnostic difficulties. Our objectives were to determine the number of traumatic LPs performed at the BC Children's Hospital over 9 years and whether there was an association between traumatic LPs and demographic variables, hospital location, or time of the procedure. STUDY DESIGN:  This study was a retrospective review of neonatal CSF samples from May 2006 to March 2015...
December 29, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/29236131/trends-in-incidence-and-long-term-outcomes-of-myelomeningocele-in-british-columbia
#2
Taylor North, Alexander Cheong, Paul Steinbok, Julia Ae Radic
PURPOSE: Myelomeningocele is typically a disabling condition that results in neurologic, orthopedic, and urologic morbidity. The aim of this study was to examine the trends over time in both incidence and outcomes of myelomeningocele (MMC) in British Columbia (BC). METHODS: A retrospective chart review was performed of all children with MMC followed in the British Columbia Children's Hospital (BCCH) Spinal Cord Clinic between 1971 and 2016. The incidence of new MMC cases and the long-term outcomes of MMC were compared between two 10-year cohorts...
December 13, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29200674/effectiveness-of-three-prognostic-scoring-systems-in-predicting-the-response-and-outcome-in-pediatric-chronic-myeloid-leukemia-chronic-phase-on-frontline-imatinib
#3
Ranga Raman Ganta, Srividya Nasaka, Vijay Gandhi Linga, Sadashivudu Gundeti, Lakshmi Srinivas Maddali, Raghunadha Rao Digumarti
Introduction: The Sokal and Hasford (Euro) scores were developed in the chemotherapy and interferon eras and are widely used as prognostic indicators in patients with chronic myeloid leukemia (CML). Recently, European Treatment and Outcome Study (EUTOS) scoring system was introduced. Data on risk stratification in pediatric CML population was lacking due to its rarity (<3%). Objective: To study the effectiveness in predicting the response and outcome with three prognostic scores in pediatric CML-chronic phase patients on front line Imatinib...
July 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/28870441/influences-on-decision-making-for-young-women-undergoing-bilateral-prophylactic-mastectomy
#4
Rachael Glassey, Moira O'Connor, Angela Ives, Christobel Saunders, Sarah J Hardcastle
OBJECTIVE: The objective of this study was to explore the influences on decision-making of younger women (<35) undergoing or considering bilateral prophylactic mastectomy (BPM). METHODS: Qualitative interviews guided by interpretative phenomenological analysis (IPA) were conducted with forty-six women who had a strong family history of breast cancer (BC) who had either undergone (n=26) or were considering (n=20) BPM. Participants were recruited from Australia and New Zealand (NZ) via hospitals, a genetics clinic, a research cohort, a registry and online...
August 24, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28834841/lymphatic-malformation-architecture-implications-for-treatment-with-ok-432
#5
Claudia C Malic, Regan Guilfoyle, Rebecca J M Courtemanche, Jugpal S Arneja, Manraj K S Heran, Douglas J Courtemanche
PURPOSE: Herein, the authors aim to describe their findings of novel architectural types of lymphatic malformations (LM) and explain the relationship between these architectures and OK-432 treatment outcomes. METHODS: A retrospective review was conducted of all patients diagnosed with a LM treated with OK-432 at the Vascular Anomalies Clinic at BC Children's Hospital from December 2002 to January 2012. RESULTS: Twenty-seven patients were included in the study...
October 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28511603/clinical-experience-with-perampanel-for-refractory-pediatric-epilepsy-in-one-canadian-center
#6
Anita N Datta, Qi Xu, Shafina Sachedina, Cyrus Boelman, Linda Huh, Mary B Connolly
Perampanel (PER) is a new antiseizure medication that inhibits the α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) class of glutamate receptors. It is important for physicians to be aware of the efficacy and tolerability of new drugs in the postmarketing phase. We performed a retrospective review of our experience with perampanel at BC Children's Hospital. Twenty-four pediatric patients prescribed perampanel from 2014 to 2016 were identified. Fifteen (63%) discontinued perampanel, and 10 (42%) had greater than 50% reduction in seizures...
January 1, 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28479124/opsoclonus-myoclonus-syndrome-a-new-era-of-improved-prognosis
#7
Armine Galstyan, Colin Wilbur, Kathryn Selby, Juliette Hukin
BACKGROUND: Opsoclonus-myoclonus syndrome is an autoimmune neurological disorder characterized by opsoclonus, myoclonus, ataxia, and behavioral changes. Although long-term outcomes have historically been poor, including motor and cognitive disabilities, the advent of new and more aggressive immunotherapy regimens may be improving prognosis in opsoclonus-myoclonus syndrome. METHODS: We retrospectively reviewed the records of all children diagnosed with opsoclonus-myoclonus syndrome at BC Children's Hospital from 2000 to 2010...
July 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28445485/validity-and-reliability-of-the-physical-activity-questionnaire-for-children-paq-c-and-adolescents-paq-a-in-individuals-with-congenital-heart-disease
#8
Christine Voss, Paige H Dean, Ross F Gardner, Stephanie L Duncombe, Kevin C Harris
OBJECTIVE: To assess the criterion validity, internal consistency, reliability and cut-point for the Physical Activity Questionnaire for Children (PAQ-C) and Adolescents (PAQ-A) in children and adolescents with congenital heart disease-a special population at high cardiovascular risk in whom physical activity has not been extensively evaluated. METHODS: We included 84 participants (13.6±2.9 yrs, 50% female) with simple (37%), moderate (31%), or severe congenital heart disease (27%), as well as cardiac transplant recipients (6%), from BC Children's Hospital, Canada...
2017: PloS One
https://www.readbyqxmd.com/read/28439664/women-at-familial-risk-of-breast-cancer-electing-for-prophylactic-mastectomy-frequencies-procedures-and-decision-making-characteristics
#9
Sarah Schott, Lisa Vetter, Monika Keller, Thomas Bruckner, Michael Golatta, Sabine Eismann, Nicola Dikow, Christina Evers, Christof Sohn, Joerg Heil
BACKGROUND: Some women of families at high risk of breast cancer (BC) choose prophylactic mastectomy (PM) in spite of ambiguous evidence for survival benefits. The aim of this study was to investigate counselees' characteristics, decisions on PM, and frequencies of different procedures to better understand how to tailor interventions. PATIENTS AND METHODS: Eight hundred and forty-nine counselees who attended interdisciplinary consultation for genetic risk adjustment at the University Hospital Heidelberg between July 2009 and July 2011 received a tripartite questionnaire addressing sociodemographic characteristics, psychological parameters, behavioural questions, and medical data...
June 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28348428/respiratory-syncytial-virus-infection-rates-with-limited-use-of-palivizumab-for-infants-born-at-29-to-31-6-7-weeks-gestational-age
#10
Brandi Newby, Todd Sorokan
BACKGROUND: Immunoprophylaxis with palivizumab can reduce respiratory syncytial virus (RSV) infections and hospitalizations. Criteria in British Columbia limit the use of palivizumab to infants born at 29 to 31+6/7 weeks gestational age, which differ from guidelines of the American Academy of Pediatrics (AAP) and the Canadian Paediatric Society (CPS). OBJECTIVE: To determine whether the limited use of palivizumab affected the frequency of hospital visits by RSV-positive infants (termed "RSV-positive hospital visits") who received approval for palivizumab and those who met the AAP/CPS criteria but did not receive approval for palivizumab...
January 2017: Canadian Journal of Hospital Pharmacy
https://www.readbyqxmd.com/read/28176013/impact-of-reproductive-factors-on-breast-cancer-subtypes-in-postmenopausal-women-a-retrospective-single-center-study
#11
Alexandra von Au, Mona Klotzbuecher, Lorenz Uhlmann, Mark Boudewijns, Laura Michel, Markus Wallwiener, Joerg Heil, Michael Golatta, Joachim Rom, Christof Sohn, Andreas Schneeweiss, Florian Schuetz, Christoph Domschke
PURPOSE: Some reproductive factors are well-known general risk factors for breast cancer (BC). On the other hand, BC subtypes also have a high prognostic value. Correlations, however, that link these risk factors to the development of a particular one of the different BC subtypes are still poorly understood. The primary objective of our study was to assess the influence of different reproductive factors (duration of breastfeeding, parity, and age at first childbirth) on pathological BC subtypes...
April 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28151006/business-planning-for-a-campus-wide-biobank
#12
Tamsin E Tarling, Frances Lasser, Candace Carter, Lise A M Matzke, Gurm Dhugga, Nidhi Arora, Simon Dee, Jodi LeBlanc, Sindy Babinsky, Sheila O'Donoghue, Stefanie Cheah, Peter Watson, Suzanne M Vercauteren
Biobanks are resources that facilitate research. Many biobanks exist around the world, but most tend to focus on a specific disease or research area. BC Children's Hospital and BC Women's Hospital are located on the same campus (Oak Street Campus) in Vancouver, BC, Canada. A campus-wide biobank has been established on the site of these two hospitals to collect specimens and annotated data from children or women seeking medical care at either of the hospitals. Such an initiative requires careful planning and consideration of many factors such as buy in and support of key stakeholders, governance, financial planning, and optimizing specimen collection...
February 2017: Biopreservation and Biobanking
https://www.readbyqxmd.com/read/28052061/integrated-genomic-characterization-of-oesophageal-carcinoma
#13
(no author information available yet)
Oesophageal cancers are prominent worldwide; however, there are few targeted therapies and survival rates for these cancers remain dismal. Here we performed a comprehensive molecular analysis of 164 carcinomas of the oesophagus derived from Western and Eastern populations. Beyond known histopathological and epidemiologic distinctions, molecular features differentiated oesophageal squamous cell carcinomas from oesophageal adenocarcinomas. Oesophageal squamous cell carcinomas resembled squamous carcinomas of other organs more than they did oesophageal adenocarcinomas...
January 12, 2017: Nature
https://www.readbyqxmd.com/read/27747739/injury-risk-in-british-columbia-canada-1986-to-2009-are-aboriginal-children-and-youth-over-represented
#14
M Anne George, Andrew Jin, Mariana Brussoni, Christopher E Lalonde, Rod McCormick
BACKGROUND: Children and youth worldwide are at high risk of injury resulting in morbidity, disability or mortality. Disparities in risk exist between and within countries, and by sex and ethnicity. Our aim is to contribute data on disparities of injury rates for Aboriginal children and youth compared with those of the general population in British Columbia (BC), Canada, by examining risks for the two populations, utilizing provincial administrative data over a 24-year period. METHODS: Hospital discharge records from the provincial health care database for children and youth were used to identify injury for the years 1986 to 2009...
December 2015: Injury Epidemiology
https://www.readbyqxmd.com/read/27740845/time-trends-and-determinants-of-fistula-in-cleft-patients-at-bc-children-s-hospital-canada-a-retrospective-18-year-medical-chart-audit
#15
Negar Salimi, Jolanta Aleksejūnienė, Edwin Yen, Angelina Loo
OBJECTIVE:   To examine the time trends and determinants of palatal fistula in children with different types of cleft at British Columbia's Children's Hospital between 1995 and 2012. METHODS:   A total of 558 medical charts of nonsyndromic patients with cleft lip and palate were eligible for the chart review. The occurrence of primary palatal fistula was assessed at any time throughout the patient's total observation period. Three types of clefts were recorded: unilateral cleft lip and palate (ULCLP), bilateral cleft lip and palate (BLCLP), and isolated cleft palate (ICP)...
October 14, 2016: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/27631207/effects-of-bovine-colostrum-on-recurrent-respiratory-tract-infections-and-diarrhea-in-children
#16
MULTICENTER STUDY
Khaled Saad, Mohamed Gamil M Abo-Elela, Khaled A Abd El-Baseer, Ahmed E Ahmed, Faisal-Alkhateeb Ahmad, Mostafa S K Tawfeek, Amira A El-Houfey, Mohamed Diab AboulKhair, Ahmad M Abdel-Salam, Amir Abo-Elgheit, Heba Qubaisy, Ahmed M Ali, Eman Abdel-Mawgoud
BACKGROUND: Bovine colostrum (BC) has direct antimicrobial and endotoxin-neutralizing effects throughout the alimentary tract, as well as other bioactivities that suppress gut inflammation and promote mucosal integrity and tissue repair under various conditions related to tissue injury. The precise role of BC in respiratory and gastrointestinal (GI) infections in children is not well defined. The aim of this study was to evaluate the efficacy and tolerability of BC administration in preventing recurrent upper respiratory tract infections (URTI) and diarrhea in children...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27525395/-investigation-of-mycobacterium-bovis-subsp-bovis-among-the-strains-of-mycobacterium-tuberculosis-complex-isolated-in-d%C3%A3-zce-province-turkey
#17
Cihadiye Elif Öztürk, İdris Şahin, Şükrü Öksüz, Nida Kılıç, Özge Kılınçel, Leyla Aydın, Dursun Atik, Emine Afşin
Throughout the history of mankind, tuberculosis (TB) has caused serious illness and still continues to do so. Archaeobiological studies indicated that TB in humans dates back to 4000-8000 BC, and cases were shown to be due to Mycobacterium bovis subsp.bovis rather than Mycobacterium tuberculosis. Moreover, this situation was thought to begin with domestication of animals, consumption of their milk, and living together in the same environment with them. Over time, with the consumption of boiled milk and with the establishment of separate animal shelters, M...
July 2016: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/27477929/quality-of-life-in-breast-cancer-sufferers
#18
Ahmed Essmat Shouman, Nahla Fawzy Abou El Ezz, Nivine Gado, Amal Mahmoud Ibrahim Goda
Purpose - The purpose of this paper is to measure health-related quality of life (QOL) among patients with early stage cancer breast under curative treatment at department of oncology and nuclear medicine at Ain Shams University Hospitals. Identify factors affecting QOL among these patients. Design/methodology/approach - A cross-sectional study measured QOL among early stage female breast cancer (BC) patients and determined the main factors affecting their QOL. Three interviewer administered questionnaires were used...
August 8, 2016: International Journal of Health Care Quality Assurance
https://www.readbyqxmd.com/read/27339060/a-clustering-approach-to-identify-severe-bronchiolitis-profiles-in-children
#19
MULTICENTER STUDY
Orianne Dumas, Jonathan M Mansbach, Tuomas Jartti, Kohei Hasegawa, Ashley F Sullivan, Pedro A Piedra, Carlos A Camargo
OBJECTIVE: Although bronchiolitis is generally considered a single disease, recent studies suggest heterogeneity. We aimed to identify severe bronchiolitis profiles using a clustering approach. METHODS: We analysed data from two prospective, multicentre cohorts of children younger than 2 years hospitalised with bronchiolitis, one in the USA (2007-2010 winter seasons, n=2207) and one in Finland (2008-2010 winter seasons, n=408). Severe bronchiolitis profiles were determined by latent class analysis, classifying children based on clinical factors and viral aetiology...
August 2016: Thorax
https://www.readbyqxmd.com/read/27276562/exome-sequencing-and-the-management-of-neurometabolic-disorders
#20
Maja Tarailo-Graovac, Casper Shyr, Colin J Ross, Gabriella A Horvath, Ramona Salvarinova, Xin C Ye, Lin-Hua Zhang, Amit P Bhavsar, Jessica J Y Lee, Britt I Drögemöller, Mena Abdelsayed, Majid Alfadhel, Linlea Armstrong, Matthias R Baumgartner, Patricie Burda, Mary B Connolly, Jessie Cameron, Michelle Demos, Tammie Dewan, Janis Dionne, A Mark Evans, Jan M Friedman, Ian Garber, Suzanne Lewis, Jiqiang Ling, Rupasri Mandal, Andre Mattman, Margaret McKinnon, Aspasia Michoulas, Daniel Metzger, Oluseye A Ogunbayo, Bojana Rakic, Jacob Rozmus, Peter Ruben, Bryan Sayson, Saikat Santra, Kirk R Schultz, Kathryn Selby, Paul Shekel, Sandra Sirrs, Cristina Skrypnyk, Andrea Superti-Furga, Stuart E Turvey, Margot I Van Allen, David Wishart, Jiang Wu, John Wu, Dimitrios Zafeiriou, Leo Kluijtmans, Ron A Wevers, Patrice Eydoux, Anna M Lehman, Hilary Vallance, Sylvia Stockler-Ipsiroglu, Graham Sinclair, Wyeth W Wasserman, Clara D van Karnebeek
BACKGROUND: Whole-exome sequencing has transformed gene discovery and diagnosis in rare diseases. Translation into disease-modifying treatments is challenging, particularly for intellectual developmental disorder. However, the exception is inborn errors of metabolism, since many of these disorders are responsive to therapy that targets pathophysiological features at the molecular or cellular level. METHODS: To uncover the genetic basis of potentially treatable inborn errors of metabolism, we combined deep clinical phenotyping (the comprehensive characterization of the discrete components of a patient's clinical and biochemical phenotype) with whole-exome sequencing analysis through a semiautomated bioinformatics pipeline in consecutively enrolled patients with intellectual developmental disorder and unexplained metabolic phenotypes...
June 9, 2016: New England Journal of Medicine
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