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BC Children's Hospital

Alexandra von Au, Mona Klotzbuecher, Lorenz Uhlmann, Mark Boudewijns, Laura Michel, Markus Wallwiener, Joerg Heil, Michael Golatta, Joachim Rom, Christof Sohn, Andreas Schneeweiss, Florian Schuetz, Christoph Domschke
PURPOSE: Some reproductive factors are well-known general risk factors for breast cancer (BC). On the other hand, BC subtypes also have a high prognostic value. Correlations, however, that link these risk factors to the development of a particular one of the different BC subtypes are still poorly understood. The primary objective of our study was to assess the influence of different reproductive factors (duration of breastfeeding, parity, and age at first childbirth) on pathological BC subtypes...
February 7, 2017: Archives of Gynecology and Obstetrics
Tamsin E Tarling, Frances Lasser, Candace Carter, Lise A M Matzke, Gurm Dhugga, Nidhi Arora, Simon Dee, Jodi LeBlanc, Sindy Babinsky, Sheila O'Donoghue, Stefanie Cheah, Peter Watson, Suzanne M Vercauteren
Biobanks are resources that facilitate research. Many biobanks exist around the world, but most tend to focus on a specific disease or research area. BC Children's Hospital and BC Women's Hospital are located on the same campus (Oak Street Campus) in Vancouver, BC, Canada. A campus-wide biobank has been established on the site of these two hospitals to collect specimens and annotated data from children or women seeking medical care at either of the hospitals. Such an initiative requires careful planning and consideration of many factors such as buy in and support of key stakeholders, governance, financial planning, and optimizing specimen collection...
February 2017: Biopreservation and Biobanking
(no author information available yet)
Oesophageal cancers are prominent worldwide; however, there are few targeted therapies and survival rates for these cancers remain dismal. Here we performed a comprehensive molecular analysis of 164 carcinomas of the oesophagus derived from Western and Eastern populations. Beyond known histopathological and epidemiologic distinctions, molecular features differentiated oesophageal squamous cell carcinomas from oesophageal adenocarcinomas. Oesophageal squamous cell carcinomas resembled squamous carcinomas of other organs more than they did oesophageal adenocarcinomas...
January 12, 2017: Nature
M Anne George, Andrew Jin, Mariana Brussoni, Christopher E Lalonde, Rod McCormick
BACKGROUND: Children and youth worldwide are at high risk of injury resulting in morbidity, disability or mortality. Disparities in risk exist between and within countries, and by sex and ethnicity. Our aim is to contribute data on disparities of injury rates for Aboriginal children and youth compared with those of the general population in British Columbia (BC), Canada, by examining risks for the two populations, utilizing provincial administrative data over a 24-year period. METHODS: Hospital discharge records from the provincial health care database for children and youth were used to identify injury for the years 1986 to 2009...
December 2015: Injury Epidemiology
Negar Salimi, Jolanta Aleksejūnienė, Edwin Yen, Angelina Loo
OBJECTIVE:   To examine the time trends and determinants of palatal fistula in children with different types of cleft at British Columbia's Children's Hospital between 1995 and 2012. METHODS:   A total of 558 medical charts of nonsyndromic patients with cleft lip and palate were eligible for the chart review. The occurrence of primary palatal fistula was assessed at any time throughout the patient's total observation period. Three types of clefts were recorded: unilateral cleft lip and palate (ULCLP), bilateral cleft lip and palate (BLCLP), and isolated cleft palate (ICP)...
October 14, 2016: Cleft Palate-craniofacial Journal
Khaled Saad, Mohamed Gamil M Abo-Elela, Khaled A Abd El-Baseer, Ahmed E Ahmed, Faisal-Alkhateeb Ahmad, Mostafa S K Tawfeek, Amira A El-Houfey, Mohamed Diab AboulKhair, Ahmad M Abdel-Salam, Amir Abo-Elgheit, Heba Qubaisy, Ahmed M Ali, Eman Abdel-Mawgoud
BACKGROUND: Bovine colostrum (BC) has direct antimicrobial and endotoxin-neutralizing effects throughout the alimentary tract, as well as other bioactivities that suppress gut inflammation and promote mucosal integrity and tissue repair under various conditions related to tissue injury. The precise role of BC in respiratory and gastrointestinal (GI) infections in children is not well defined. The aim of this study was to evaluate the efficacy and tolerability of BC administration in preventing recurrent upper respiratory tract infections (URTI) and diarrhea in children...
September 2016: Medicine (Baltimore)
Cihadiye Elif Öztürk, İdris Şahin, Şükrü Öksüz, Nida Kılıç, Özge Kılınçel, Leyla Aydın, Dursun Atik, Emine Afşin
Throughout the history of mankind, tuberculosis (TB) has caused serious illness and still continues to do so. Archaeobiological studies indicated that TB in humans dates back to 4000-8000 BC, and cases were shown to be due to Mycobacterium bovis subsp.bovis rather than Mycobacterium tuberculosis. Moreover, this situation was thought to begin with domestication of animals, consumption of their milk, and living together in the same environment with them. Over time, with the consumption of boiled milk and with the establishment of separate animal shelters, M...
July 2016: Mikrobiyoloji Bülteni
Ahmed Essmat Shouman, Nahla Fawzy Abou El Ezz, Nivine Gado, Amal Mahmoud Ibrahim Goda
Purpose - The purpose of this paper is to measure health-related quality of life (QOL) among patients with early stage cancer breast under curative treatment at department of oncology and nuclear medicine at Ain Shams University Hospitals. Identify factors affecting QOL among these patients. Design/methodology/approach - A cross-sectional study measured QOL among early stage female breast cancer (BC) patients and determined the main factors affecting their QOL. Three interviewer administered questionnaires were used...
August 8, 2016: International Journal of Health Care Quality Assurance
Orianne Dumas, Jonathan M Mansbach, Tuomas Jartti, Kohei Hasegawa, Ashley F Sullivan, Pedro A Piedra, Carlos A Camargo
OBJECTIVE: Although bronchiolitis is generally considered a single disease, recent studies suggest heterogeneity. We aimed to identify severe bronchiolitis profiles using a clustering approach. METHODS: We analysed data from two prospective, multicentre cohorts of children younger than 2 years hospitalised with bronchiolitis, one in the USA (2007-2010 winter seasons, n=2207) and one in Finland (2008-2010 winter seasons, n=408). Severe bronchiolitis profiles were determined by latent class analysis, classifying children based on clinical factors and viral aetiology...
August 2016: Thorax
Maja Tarailo-Graovac, Casper Shyr, Colin J Ross, Gabriella A Horvath, Ramona Salvarinova, Xin C Ye, Lin-Hua Zhang, Amit P Bhavsar, Jessica J Y Lee, Britt I Drögemöller, Mena Abdelsayed, Majid Alfadhel, Linlea Armstrong, Matthias R Baumgartner, Patricie Burda, Mary B Connolly, Jessie Cameron, Michelle Demos, Tammie Dewan, Janis Dionne, A Mark Evans, Jan M Friedman, Ian Garber, Suzanne Lewis, Jiqiang Ling, Rupasri Mandal, Andre Mattman, Margaret McKinnon, Aspasia Michoulas, Daniel Metzger, Oluseye A Ogunbayo, Bojana Rakic, Jacob Rozmus, Peter Ruben, Bryan Sayson, Saikat Santra, Kirk R Schultz, Kathryn Selby, Paul Shekel, Sandra Sirrs, Cristina Skrypnyk, Andrea Superti-Furga, Stuart E Turvey, Margot I Van Allen, David Wishart, Jiang Wu, John Wu, Dimitrios Zafeiriou, Leo Kluijtmans, Ron A Wevers, Patrice Eydoux, Anna M Lehman, Hilary Vallance, Sylvia Stockler-Ipsiroglu, Graham Sinclair, Wyeth W Wasserman, Clara D van Karnebeek
BACKGROUND: Whole-exome sequencing has transformed gene discovery and diagnosis in rare diseases. Translation into disease-modifying treatments is challenging, particularly for intellectual developmental disorder. However, the exception is inborn errors of metabolism, since many of these disorders are responsive to therapy that targets pathophysiological features at the molecular or cellular level. METHODS: To uncover the genetic basis of potentially treatable inborn errors of metabolism, we combined deep clinical phenotyping (the comprehensive characterization of the discrete components of a patient's clinical and biochemical phenotype) with whole-exome sequencing analysis through a semiautomated bioinformatics pipeline in consecutively enrolled patients with intellectual developmental disorder and unexplained metabolic phenotypes...
June 9, 2016: New England Journal of Medicine
Allan Brand, Kathleen E McLean, Sarah B Henderson, Michel Fournier, Ling Liu, Tom Kosatsky, Audrey Smargiassi
BACKGROUND: Industrial plants emit air pollutants like fine particles (PM2.5), sulfur dioxide (SO2) and nitrogen dioxide (NO2) that may affect the health of individuals living nearby. OBJECTIVE: To assess the effects of community exposure to air emissions of PM2.5, SO2, and NO2 from pulp mills, oil refineries, metal smelters, on respiratory hospital admissions in young children in Quebec (QC) and British Columbia (BC), Canada. METHODS: We assessed QC, BC and pooled associations between the following estimates of exposure and hospital admissions for asthma and bronchiolitis in children aged 2-4years for the years 2002-2010: i) Crude emission exposures at the residential postal codes of children, calculated by multiplying estimated daily emissions of PM2...
September 2016: Environment International
Gelareh S Noureddin, Sachiko Sasaki, Andrea L Butler, Peter Tilley, Diane Roscoe, Christopher J Lyons, Simon P Holland, Sonia N Yeung
OBJECTIVE: To report the clinical and microbiological profiles of paediatric patients with infectious keratitis in Vancouver, Canada. DESIGN: In this observational case series, the microbiology results and medical records of 17 eyes with microbial keratitis in 16 children aged 17 years or younger were retrospectively reviewed. These patients had undergone corneal scraping between May 2006 and April 2011 at BC Children's Hospital or Vancouver General Hospital Eye Care Centre in Vancouver, British Columbia, Canada...
March 30, 2016: British Journal of Ophthalmology
Kim Hesketh, Wudbhav Sankar, Benjamin Joseph, Unni Narayanan, Kishore Mulpuri
PURPOSE: The incidence of avascular necrosis (AVN) following reconstructive hip surgery in cerebral palsy (CP) ranges from 0 to 69 % in the current literature. The purpose of this study was to determine the inter- and intra-observer reliability of radiographically diagnosing AVN in children with CP after hip surgery. METHODS: A retrospective review of 65 children with CP who had reconstructive hip surgery between 2009 and 2012 at BC Children's Hospital was completed...
April 2016: Journal of Children's Orthopaedics
Dianne G Valenzuela, Divjot Singh Kumar, Cheryl Labelle Atkins, Alison Beers, Frederick K Kozak, Neil K Chadha
INTRODUCTION: The auditory brainstem response (ABR) test is used to identify hearing loss and measure hearing thresholds of infants and children who cannot be tested using standard behavioral hearing testing methods. In order for the ABR to yield useful data, a child must be asleep throughout the duration of the test. In many centers, this is achieved through the use of a general anesthetic, with its inherent risks and costs. Since 2004, ABRs have been routinely conducted at BC Children's Hospital in an ambulatory care setting under oral chloral hydrate sedation, with monitoring by a specialist nurse...
April 2016: International Journal of Pediatric Otorhinolaryngology
Lisa Vetter, Monika Keller, Thomas Bruckner, Michael Golatta, Sabine Eismann, Christina Evers, Nicola Dikow, Christof Sohn, Jörg Heil, Sarah Schott
Breast cancer (BC) is the leading cancer among women worldwide and in 5-10 % of cases is of hereditary origin, mainly due to BRCA1/2 mutations. Therefore, the German Consortium for Familial Breast and Ovarian Cancer (HBOC) with its 15 specialized academic centers offers families at high risk for familial/hereditary cancer a multimodal breast cancer surveillance program (MBCS) with regular breast MRI, mammography, ultrasound, and palpation. So far, we know a lot about the psychological effects of genetic testing, but we know little about risk-correlated adherence to MBCS or prophylactic surgery over time...
April 2016: Breast Cancer Research and Treatment
David Vyles, Forrest Gnagi, Blake Bulloch, Jared Muenzer, Chengcheng Hu
BACKGROUND: Children undergoing treatment for acute lymphoblastic leukemia (ALL) often present to the emergency department (ED) with a fever. They are at high risk of bacteremia secondary to being immunocompromised. Recent reports indicate that procalcitonin (PCT) is a useful marker of bacteremia in children. OBJECTIVE: Our objective was to evaluate the clinical utility of PCT as a rapid marker of bacteremia in children with ALL presenting to the ED with a fever...
September 2016: Pediatric Emergency Care
David A Danford, Quentin Karels, Aparna Kulkarni, Aysha Hussain, Yunbin Xiao, Shelby Kutty
BACKGROUND: Quantifying resource utilization in the inpatient care of congenital heart diease is clinically relevant. Our purpose is to measure the investment of inpatient care resources to achieve survival in hypoplastic left heart syndrome (HLHS), and to determine how much of that investment occurs in hospitalizations that have a fatal outcome, the mortality-related resource utilization fraction (MRRUF). METHODS: A collaborative administrative database, the Pediatric Health Information System (PHIS) containing data for 43 children's hospitals, was queried by primary diagnosis for HLHS admissions of patients ≤21 years old during 2004-2013...
2015: Orphanet Journal of Rare Diseases
Anna Longdoh Njunda, Shuri Ghasarah Fon, Jules Clement Nguedia Assob, Dickson Shey Nsagha, Tayong Dizzle Bita Kwenti, Tebit Emmanuel Kwenti
BACKGROUND: The purpose of this study was to determine the prevalence of coinfection with malaria and intestinal parasites, as well as to determine its association with anaemia in children aged 10 years and below in Muyuka, Cameroon. MATERIALS AND METHODS: This was a cross-sectional study. Participants were febrile children who were admitted to the Muyuka district hospital between April and October 2012. Blood and stool samples were collected from those participants who gave consent to take part in the study...
2015: Infectious Diseases of Poverty
Monica Khurana, Brian Lee, James H Feusner
INTRODUCTION: With new multidrug-resistant microbes and the paucity of new antibacterial agents, we must identify opportunities to safely minimize antibiotics. Current guidelines encourage empiric antibiotics in febrile patients with chemotherapy-induced neutropenia to reduce infection-related mortalities. No guidelines exist for children with isolated fever at presentation/diagnosis of acute lymphoblastic leukemia (ALL) and before starting chemotherapy. This study evaluates the incidence of bacteremia in this subpopulation...
October 2015: Journal of Pediatric Hematology/oncology
Harry R F Powell, Alison M Rolfe, Catherine S Birman
OBJECTIVE: In 1977, Tjellstrom et al. used the concept of osseointegration and implanted patients with a titanium screw as part of the first bone-anchored hearing solution. Despite good hearing outcomes with the percutaneous device, there has been a drive for the development of transcutaneous bone conduction systems because of soft tissue complications, aesthetics, and loss or failure of the abutment. This study compares audiologic and quality of life questionnaire outcomes (author-designed questionnaire) for two transcutaneous bone conduction implants...
September 2015: Otology & Neurotology
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