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Wound healing and oxygenation

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https://www.readbyqxmd.com/read/28935291/efficacy-and-safety-of-hyperbaric-oxygen-therapy-used-in-patients-with-diabetic-foot-a-meta-analysis-of-randomized-clinical-trials
#1
REVIEW
Di Zhao, Shaowei Luo, Wencan Xu, Jun Hu, Shaoda Lin, Nasui Wang
PURPOSE: The efficacy and safety profile of hyperbaric oxygen therapy (HBOT) in patients with diabetic foot ulcer have been controversial in recent years. Our meta-analysis was undertaken to evaluate the efficacy and safety profile of HBOT in patients with diabetic foot ulcer. METHODS: We searched the PubMed, Cochrane Library, EMBASE, and Clinical Trials.gov databases for controlled trials. The efficacy end points included the incidence of healed ulcers, major amputations, minor amputations, and reduction in the ulcer wound area...
September 18, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28933415/integrative-systems-biology-investigation-of-fabry-disease
#2
Marco Fernandes, Holger Husi
Fabry disease (FD) is a rare X-linked recessive genetic disorder caused by a deficient activity of the lysosomal enzyme alpha-galactosidase A (GLA) and is characterised by intra-lysosomal accumulation of globotriaosylceramide (Gb3). We performed a meta-analysis of peer-reviewed publications including high-throughput omics technologies including naïve patients and those undergoing enzyme replacement therapy (ERT). This study describes FD on a systems level using a systems biology approach, in which molecular data sourced from multi-omics studies is extracted from the literature and integrated as a whole in order to reveal the biochemical processes and molecular pathways potentially affected by the dysregulation of differentially expressed molecules...
November 15, 2016: Diseases (Basel)
https://www.readbyqxmd.com/read/28929035/porcine-urinary-bladder-matrix-for-management-of-infected-radiation-mastectomy-wound
#3
Yana Puckett, Theophilus Pham, Shirley McReynolds, Catherine A Ronaghan
We present a case report on the successful healing of a Pseudomonas infection wound in a 52-year-old female with morbid obesity, noninsulin dependent diabetes mellitus and a history of tobacco use, who presented with Stage IIIA (T3, N2, Mo) infiltrating ductal carcinoma. The patient received neoadjuvant chemotherapy prior to her bilateral skin-sparing total mastectomies with right axillary sentinel lymphadenectomy. She also had staged reconstruction with temporary breast implants and plans for deep inferior epigastric perforator flaps...
July 10, 2017: Curēus
https://www.readbyqxmd.com/read/28914189/a-hopeful-prospect-of-riociguat-as-a-soluble-guanylate-cyclase-stimulator-for-management-of-pressure-ulcers
#4
Soha Azadi, Hajar Ashrafi, Amir Azadi
Pressure ulcer remains as a common problem, especially developed in disabled patients and hence, subjected to continuous pressure for prolonged periods of time. Most of the studies investigating the preventive and therapeutic approaches have focused on wound cleansing, dressing and supportive strategies , as well as pharmacological therapy including zinc sulphate, vitamin A or phenytoin. Despite such efforts, pressure ulcer continues to impair the life quality and expectancy. Thus involving in the paradigm shift in biomedical studies, the recent ones focus on biological signaling pathways involving nitric oxide (NO)- soluble guanylatecyclase (sGC)- cyclic guanosine monophosphate (cGMP) contributing in vasodilation, reperfusion and oxygen delivery...
September 15, 2017: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/28885215/hyperspectral-imaging-as-a-novel-diagnostic-tool-in-microcirculation-of-wounds
#5
Georg Daeschlein, Inga Langner, Thomas Wild, Sebastian von Podewils, Claudia Sicher, Thomas Kiefer, Michael Jünger
Monitoring of perfusion is a cornerstone in surgery, phlebology and basic science to proof wound healing by interventions. In chronic wound management it is of utmost importance to realize and parametrize wound bed perfusion to verify actual, and plan further treatment by noninvasive diagnostics. Up to now monitoring is based on visual inspection of wounds as conventionally practiced over more than decades. The main problems of visual inspection are the lack of standardization and comparability because of interindividual variations...
September 4, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28867725/wound-healing-effect-of-slightly-acidic-electrolyzed-water-on-cutaneous-wounds-in-hairless-mice-via-immune-redox-modulation
#6
Hae Sun You, Ailyn Fadriquela, Ma Easter Joy Sajo, Johny Bajgai, Jesmin Ara, Cheol Su Kim, Soo-Ki Kim, Jin Rok Oh, Kwang Yong Shim, Hyun Kyo Lim, Kyu-Jae Lee
Acidic electrolyzed water is an innovative sanitizer having a wide-spectrum of applications in food industry, and healthcare industry but little is known on its effect and mechanism in wound healing. The study was conducted to identify the effect and mechanism of slightly acidic electrolyzed water (SAEW) on cutaneous wounds in hairless mice. SAEW (pH: 5-6.5, oxidation reduction potential: 800 mV, chlorine concentration: 25 ppm) was prepared through electrolysis of water and was applied to the wounds of hairless mice three times a day for seven days...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28866140/perioperative-supplementation-with-a-fruit-and-vegetable-juice-powder-concentrate-and-postsurgical-morbidity-a-double-blind-randomised-placebo-controlled-clinical-trial
#7
Patricia Gorecki, Danielle L Burke, Iain L C Chapple, Karla Hemming, Daniel Saund, David Pearson, Wilhelm Stahl, Ryan Lello, Thomas Dietrich
BACKGROUND & AIMS: Surgical trauma leads to an inflammatory response that causes surgical morbidity. Reduced antioxidant micronutrient (AM)(a) levels and/or excessive levels of Reactive Oxygen Species (ROS)(b) have previously been linked to delayed wound healing and presence of chronic wounds. We aimed to evaluate the effect of pre-operative supplementation with encapsulated fruit and vegetable juice powder concentrate (JuicePlus+(®)) on postoperative morbidity and Quality of Life (QoL)(c)...
August 10, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28860917/hyperbaric-oxygen-in-the-management-of-wound-tissue-necrosis-after-external-dacrocystorhinostomy
#8
Alicia Galindo-Ferreiro, Ahmed Ghetami, Diego Strianese, Sahar Elkhamary, Deepak P Edward, Antonio Palma, Silvana A Schellini
Hyperbaric oxygen is an adjunctive treatment for promoting wound healing and reducing infection. We present an unusual case of wound tissue necrosis occurring after external dacryocystorhinostomy (ExtDCR) that was subsequently treated with hyperbaric oxygen (HBO) and advancement flaps with good outcome. HBO improves vascularization of ischemic tissues after ExtDCR for greater success after reconstructive surgery.
July 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28860757/photodynamic-antimicrobial-chemotherapy-for-staphylococcus-aureus-and-multidrug-resistant-bacterial-burn-infection-in-vitro-and-in-vivo
#9
Bingjie Mai, Yiru Gao, Min Li, Xiaobing Wang, Kun Zhang, Quanhong Liu, Chuanshan Xu, Pan Wang
BACKGROUND AND OBJECTIVES: Antibiotic resistance has emerged as one of the most important determinants of outcome in patients with serious infections, along with the virulence of the underlying pathogen. Photodynamic antimicrobial chemotherapy (PACT) has been proposed as an alternative approach for the inactivation of bacteria. This study aims to evaluate the antibacterial effect of sinoporphyrin sodium (DVDMS)-mediated PACT on Staphylococcus aureus and multidrug resistant S. aureus in vitro and in vivo...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28854426/autophagy-inhibition-contributes-to-ros-producing-nlrp3-dependent-inflammasome-activation-and-cytokine-secretion-in-high-glucose-induced-macrophages
#10
Jiezhi Dai, Xiaotian Zhang, Li Li, Hua Chen, Yimin Chai
BACKGROUND: Type 2 diabetes is a persistent inflammatory response that impairs the healing process. We hypothesized that stimulation with high glucose following a pro-inflammatory signal would lead to autophagy inhibition, reactive oxygen species (ROS) production and eventually to the activation of the Nod-like receptor protein (NLRP) -3. METHODS: Macrophages were isolated from human diabetic wound. We measured the expression of NLRP3, caspase1 and interleukin-1 beta (IL-1β) by western blot and real-time PCR, and the surface markers on cells by flow cytometry...
August 30, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28841191/structure-identification-and-in-vitro-anticancer-activity-of-lathyrol-3-phenylacetate-5-15-diacetate
#11
Jian-Ye Zhang, Wen-Jing Huang, Hong-Mei Sun, Yun Liu, Xiao-Qin Zhao, Si-Li Tang, Ming-Na Sun, Sheng Wang, Jia-Jun Li, Ling-Ling Zhang, Jun-Hua Zhou, Qian-Rong Pan, Hu-Biao Chen
Natural products from the genus Euphorbia show attention-attracting activities, such as anticancer activity. In this article, classical isolation and structure identification were used in a study on Caper Euphorbia Seed. Subsequently, MTT and wound healing assays, flow cytometry, western blotting, Hoechst 33258 staining and fluorescence microscopy examination were applied to investigate the anticancer activity of the obtained compounds. In a result, lathyrol-3-phenyl- acetate-5,15-diacetate (deoxy Euphorbia factor L1, DEFL1) was isolated from Caper Euphorbia Seed...
August 25, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28838774/the-role-of-hyperbaric-oxygen-therapy-in-the-prevention-and-management-of-radiation-induced-complications-of-the-head-and-neck-%C3%A2-a-systematic-review-of-literature
#12
P Ravi, D Vaishnavi, A Gnanam, V B Krishnakumar Raja
Radiation therapy for the treatment of head and neck cancer can injure normal tissues and have devastating side effects. Hyperbaric oxygen (HBO) is known to reduce the severity of radiation-induced injury by promoting wound healing. While most of the research in literature has focused on its efficacy in osteonecrosis, HBO has other proven benefits as well. The aim of this review was to identify the various benefits of hyperbaric oxygen therapy in patients who have undergone radiation for head and neck cancer...
August 22, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28832120/single-continuous-near-infrared-laser-triggered-photodynamic-and-photothermal-ablation-of-antibiotic-resistant-bacteria-using-effective-targeted-copper-sulfide-nanoclusters
#13
Xiaomei Dai, Yu Zhao, Yunjian Yu, Xuelei Chen, Xiaosong Wei, Xinge Zhang, Chaoxing Li
The emergence of antibiotic-resistant bacterial strains has made conventional antibiotic therapies less efficient. The development of a novel nanoantibiotic approach for efficiently ablating such bacterial infections is becoming crucial. Herein, a collection of poly(5-(2-ethyl acrylate)-4-methylthiazole-g-butyl)/copper sulfide nanoclusters (PATA-C4@CuS) was synthesized for efficient capture and effective ablation of levofloxacin-resistant Gram-negative and Gram-positive bacteria upon tissue-penetrable near-infrared (NIR) laser irradiation...
September 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28826225/low-oxidative-stress-mediated-proliferation-via-jnk-foxo3a-catalase-signaling-in-transplanted-adult-stem-cells-promotes-wound-tissue-regeneration
#14
Neha R Dhoke, Ramasatyaveni Geesala, Amitava Das
AIMS: Stem cells exposed to pathological levels of reactive oxygen species (ROS) at wound site fail to regenerate tissue. Molecular mechanism underlying differential levels of ROS-mediated regulation of stem cells remains elusive. This study elucidates mechanistic role of catalase at 10µM H<sub>2</sub>O<sub>2</sub>-induced proliferation of mouse bone marrow stromal (BMSC) and hematopoietic (HSPC) stem/progenitor cells. RESULTS: BMSCs and HSPCs depicted an increased growth rate and colony formation, in presence of 10µM but not 100µM concentration of H<sub>2</sub>O<sub>2</sub>, an effect that was perturbed by Vit...
August 21, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28825807/photo-inspired-antibacterial-activity-and-wound-healing-acceleration-by-hydrogel-embedded-with-ag-ag-agcl-zno-nanostructures
#15
Congyang Mao, Yiming Xiang, Xiangmei Liu, Zhenduo Cui, Xianjin Yang, Kelvin Wai Kwok Yeung, Haobo Pan, Xianbao Wang, Paul K Chu, Shuilin Wu
Ag/Ag@AgCl/ZnO hybrid nanostructures are embedded in a hydrogel by a simple two-step technique. The Ag/Ag@AgCl nanostructures are assembled in the hydrogel via ultraviolet light chemical reduction followed by incorporation of ZnO nanostructures by NaOH precipitation. The hydrogel accelerates wound healing and exhibits high antibacterial efficiency against both Escherichia coli and Staphylococcus aureus under visible light irradiation. The Ag/Ag@AgCl nanostructures enhance the photocatalytic and antibacterial activity of ZnO due to the enhancement of reactive oxygen species by visible light...
August 24, 2017: ACS Nano
https://www.readbyqxmd.com/read/28821071/on-the-use-of-ion-crosslinked-nanocellulose-hydrogels-for-wound-healing-solutions-physicochemical-properties-and-application-oriented-biocompatibility-studies
#16
Alex Basu, Jonas Lindh, Eva Ålander, Maria Strømme, Natalia Ferraz
Calcium ion-crosslinked nanofibrillated cellulose (NFC) hydrogels were investigated as potential materials for wound healing dressings. The physicochemical properties of the hydrogels were examined by rheology and water retention tests. Skin cells and monocytes were selected for application-oriented biocompatibility studies. The NFC hydrogels presented entangled fibrous networks and solid-like behavior. Water retention tests showed the material´s potential to maintain a suitable moist environment for different type of wounds...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28810801/may-dietary-supplementation-augment-respiratory-burst-in-wound-site-inflammatory-cells
#17
Amitava Das, Ryan Dickerson, Piya Das Ghatak, Gayle Gordillo, Scott Chaffee, Abhijoy Saha, Savita Khanna, Sashwati Roy
Persistent infection contributes to wound chronicity. At the wound-site, NADPH oxidase activity in immune cells fights infection to enable the healing process. Fermented Papaya Preparation (FPP) is a carbohydrate-rich nutritional supplement that has demonstrated ability to bolster respiratory burst in experimental rodent systems. In FPP, glucose co-exists with fructose and maltose in addition to multiple other sugar alcohols such as inositol. We have previously reported that FPP supplementation augments wound healing in diabetic mice via improvement of respiratory-burst activity of wound innate immune cells...
August 16, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28802553/effect-of-cold-argon-plasma-on-eggs-of-the-blow-fly-lucilia-cuprina-diptera-calliphoridae
#18
Kwankamol Limsopatham, Dheerawan Boonyawan, Chanchai Umongno, Kabkaew L Sukontason, Tarinee Chaiwong, Rattana Leksomboon, Kom Sukontason
Non-thermal plasma has been used in many medical applications, including treatment of living cells, blood coagulation, wound healing, and sterilization. The process uses an environmentally friendly gas (e.g., argon, helium, oxygen, nitrogen, or hydrogen) to destroy bacteria cells with no serious adverse effect on humans or animals. However, information on the effect of argon plasma on blow fly eggs is lacking. In this study, we explored the ability of cold argon plasma to destroy the eggs of the Australian sheep blow fly, Lucilia cuprina (Wiedemann, 1830); its larvae are a myiasis-producing agent in both human and animals...
August 9, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28799332/attaching-the-nora-efflux-pump-inhibitor-inf55-to-methylene-blue-enhances-antimicrobial-photodynamic-inactivation-of-methicillin-resistant-staphylococcus-aureus-in-vitro-and-in-vivo
#19
Ardeshir Rineh, Naveen K Dolla, Anthony R Ball, Maria Magana, John B Bremner, Michael R Hamblin, George P Tegos, Michael J Kelso
Antimicrobial photodynamic inactivation (aPDI) uses photosensitizers (PSs) and harmless visible light to generate reactive oxygen species (ROS) and kill microbes. Multidrug efflux systems can moderate the phototoxic effects of PSs by expelling the compounds from cells. We hypothesized that increasing intracellular concentrations of PSs by inhibiting efflux with a covalently attached efflux pump inhibitor (EPI) would enhance bacterial cell phototoxicity and reduce exposure of neighboring host cells to damaging ROS...
August 17, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/28792822/topical-oxygenation-therapy-in-wound-care-are-patients-getting-enough
#20
Sharon Hunt
Wound management is a major burden on today's healthcare provider, both clinically with regard to available resources and financially. Most importantly, it has a significant impact on the patient's quality of life and experience. Within the field of wound care these pressures, alongside an ageing population, multiple comorbidities, disease processes and negative lifestyle choices, increase incidences of reduced skin integrity and challenging wounds. In an attempt to meet these challenges alternative, innovative therapies are being explored to support the wound healing process...
August 10, 2017: British Journal of Nursing: BJN
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