Aleksandra Mitina, Mahreen Khan, Robert Lesurf, Yue Yin, Worrawat Engchuan, Omar Hamdan, Giovanna Pellecchia, Brett Trost, Ian Backstrom, Keyi Guo, Linda M Pallotto, Phoenix Hoi Lam Doong, Zhuozhi Wang, Thomas Nalpathamkalam, Bhooma Thiruvahindrapuram, Tanya Papaz, Christopher E Pearson, Jiannis Ragoussis, Padmaja Subbarao, Meghan B Azad, Stuart E Turvey, Piushkumar Mandhane, Theo J Moraes, Elinor Simons, Stephen W Scherer, Jane Lougheed, Tapas Mondal, John Smythe, Luis Altamirano-Diaz, Erwin Oechslin, Seema Mital, Ryan K C Yuen
BACKGROUND: Cardiomyopathy is a clinically and genetically heterogeneous heart condition that can lead to heart failure and sudden cardiac death in childhood. While it has a strong genetic basis, the genetic aetiology for over 50% of cardiomyopathy cases remains unknown. METHODS: In this study, we analyse the characteristics of tandem repeats from genome sequence data of unrelated individuals diagnosed with cardiomyopathy from Canada and the United Kingdom (n = 1216) and compare them to those found in the general population...
February 26, 2024: EBioMedicine