keyword
https://read.qxmd.com/read/38450280/protection-from-cisplatin-induced-hearing-loss-with-lentiviral-vector-mediated-ectopic-expression-of-the-anti-apoptotic-protein-bcl-xl
#21
JOURNAL ARTICLE
Larissa Nassauer, Hinrich Staecker, Peixin Huang, Bryan Renslo, Madeleine Goblet, Jennifer Harre, Athanasia Warnecke, Juliane W Schott, Michael Morgan, Melanie Galla, Axel Schambach
Cisplatin is a highly effective chemotherapeutic agent, but it can cause sensorineural hearing loss (SNHL) in patients. Cisplatin-induced ototoxicity is closely related to the accumulation of reactive oxygen species (ROS) and subsequent death of hair cells (HCs) and spiral ganglion neurons (SGNs). Despite various strategies to combat ototoxicity, only one therapeutic agent has thus far been clinically approved. Therefore, we have developed a gene therapy concept to protect cochlear cells from cisplatin-induced toxicity...
March 12, 2024: Molecular Therapy. Nucleic Acids
https://read.qxmd.com/read/38448106/comparison-of-phenolic-composition-in-australian-grown-date-fruit-phoenix-dactylifera-l-seeds-from-different-varieties-and-ripening-stages
#22
JOURNAL ARTICLE
Linghong Shi, Ziyao Liu, Claudia Gonzalez Viejo, Farhad Ahmadi, Frank R Dunshea, Hafiz A R Suleria
In this research, different seeds of Australian-grown date palm (Phoenix dactylifera L.) were studied to evaluate the antioxidant potential and analyze their phenolic constituents. Phenolic compounds were extracted from seeds of various Australian-grown date varieties at different ripening stages. Eight varieties of date seeds (Zahidi, Medjool, Deglet nour, Thoory, Halawi, Barhee, Khadrawy, and Bau Strami) at three ripening stages (Kimri, Khalal, and Tamar) were investigated in this study. Date seeds at Khalal (9...
April 2024: Food Research International
https://read.qxmd.com/read/38439950/prevalence-and-antimicrobial-susceptibility-pattern-of-methicillin-resistant-staphylococcus-aureus-mrsa-at-a-maternity-and-children-hospital-in-saudi-arabia-a-cross-sectional-study
#23
JOURNAL ARTICLE
Hadiah Almutairi, Heyam Albahadel, Abdullah A Alhifany, Hind Aldalbahi, Faris S Alnezary, Ibrahim Alqusi, Mugahid A Mobark, Masaad Saeed Almutairi
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) pathogens are considered a serious global health threat, leading to increased mortality and antimicrobial resistance. Rates in Saudi Arabia remain high, necessitating continuous surveillance. This study investigates MRSA prevalence and susceptibility at a Saudi maternity and children's hospital. METHOD: A cross-sectional study was conducted on pediatric (<18 years) and maternal patients with S...
April 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38434143/a-fit-for-purpose-validation-of-a-commercial-radioimmunoassay-for-measurement-of-human-peripheral-oxytocin
#24
JOURNAL ARTICLE
Keenan Gerred, Amita Kapoor
Oxytocin (OT) is a peptide hormone synthesized in the hypothalamus and released into systemic circulation or other areas of the brain. Its physiological roles include action as a hormone with stimulation of uterine contractions and that as a neuromodulator with involvement in social behaviors and regulation of mood. Its small size and low levels within biological matrices make it challenging to accurately measure. The goal of this study was to demonstrate the specificity of the antibody, sensitivity, and reproducibility of the Phoenix Pharmaceuticals (PP) OT radioimmunoassay (RIA) for use in human urine, serum, and saliva...
July 2024: Biochemistry and Biophysics Reports
https://read.qxmd.com/read/38428356/comparison-of-gamithromycin-residue-depletion-in-yellow-feather-and-white-feather-broilers-after-one-single-subcutaneous-injection
#25
JOURNAL ARTICLE
Xing-Ping Li, Jun Liang, Ze-En Li, Ming-Hui Duan, Yan Dai, Yan-Ni Zhang, Yue Liu, Yang-Guang Jin, Fan Yang
This study aimed to compare the residue depletion of gamithromycin in yellow-feather and white-feather broilers, using Sanhuang and Arbor Acres chickens as typical examples, respectively. Each breed (54 chickens) received a single subcutaneous dose of gamithromycin at 7.5 mg/kg bodyweight (BW). Tissues, including muscle, skin + fat, liver, kidney, and injection site, were collected at 6 h, 3, 5, 7, 10, 14, 21, 28, and 35 d postdrug administration. Gamithromycin concentrations in these tissues were determined using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)...
February 20, 2024: Poultry Science
https://read.qxmd.com/read/38418836/date-fruit-melanin-is-primarily-based-on-epicatechin-proanthocyanidin-oligomers
#26
JOURNAL ARTICLE
Muneeba Zubair Alam, Clinton Emeka Okonkwo, João P Cachaneski-Lope, Carlos F O Graeff, Augusto Batagin-Neto, Saeed Tariq, Sabu Varghese, Matthew J O'Connor, Abuzar E Albadri, J Beau W Webber, Mohammed Tarique, Mutamed Ayyash, Afaf Kamal-Eldin
Plant-based melanin seems to be abundant, but it did not receive scientific attention despite its importance in plant biology and medicinal applications, e.g. photoprotection, radical scavenging, antimicrobial properties, etc. Date fruit melanin (DM) has complex, graphene-like, polymeric structure that needs characterization to understand its molecular properties and potential applications. This study provides the first investigation of the possible molecular composition of DM. High performance size-exclusion chromatography (HPSEC) suggested that DM contains oligomeric structures (569-3236 Da) and transmission electron microscopy (TEM) showed agglomeration of these structures in granules of low total porosity (10-1000 Å)...
February 28, 2024: Scientific Reports
https://read.qxmd.com/read/38418263/genome-wide-enhancer-associated-tandem-repeats-are-expanded-in-cardiomyopathy
#27
JOURNAL ARTICLE
Aleksandra Mitina, Mahreen Khan, Robert Lesurf, Yue Yin, Worrawat Engchuan, Omar Hamdan, Giovanna Pellecchia, Brett Trost, Ian Backstrom, Keyi Guo, Linda M Pallotto, Phoenix Hoi Lam Doong, Zhuozhi Wang, Thomas Nalpathamkalam, Bhooma Thiruvahindrapuram, Tanya Papaz, Christopher E Pearson, Jiannis Ragoussis, Padmaja Subbarao, Meghan B Azad, Stuart E Turvey, Piushkumar Mandhane, Theo J Moraes, Elinor Simons, Stephen W Scherer, Jane Lougheed, Tapas Mondal, John Smythe, Luis Altamirano-Diaz, Erwin Oechslin, Seema Mital, Ryan K C Yuen
BACKGROUND: Cardiomyopathy is a clinically and genetically heterogeneous heart condition that can lead to heart failure and sudden cardiac death in childhood. While it has a strong genetic basis, the genetic aetiology for over 50% of cardiomyopathy cases remains unknown. METHODS: In this study, we analyse the characteristics of tandem repeats from genome sequence data of unrelated individuals diagnosed with cardiomyopathy from Canada and the United Kingdom (n = 1216) and compare them to those found in the general population...
February 26, 2024: EBioMedicine
https://read.qxmd.com/read/38397836/optimization-metabolomic-analysis-antioxidant-potential-anddepigmenting-activity-of-polyphenolic-compounds-fromunmature-ajwa-date-seeds-phoenix-dactylifera-l-using-ultrasonic-assisted-extraction
#28
JOURNAL ARTICLE
Fanar Alshammari, Md Badrul Alam, Marufa Naznin, Sunghwan Kim, Sang-Han Lee
This study sought to optimize the ultrasonic-assisted extraction of polyphenolic compounds from unmature Ajwa date seeds (UMS), conduct untargeted metabolite identification and assess antioxidant and depigmenting activities. Response surface methodology (RSM) utilizing the Box-Behnken design (BBD) and artificial neural network (ANN) modeling was applied to optimize extraction conditions, including the ethanol concentration, extraction temperature and time. The determined optimal conditions comprised the ethanol concentration (62...
February 15, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38397779/a-sustainable-extraction-approach-of-phytochemicals-from-date-phoenix-dactylifera-l-fruit-cultivars-using-ultrasound-assisted-deep-eutectic-solvent-a-comprehensive-study-on-bioactivity-and-phenolic-variability
#29
JOURNAL ARTICLE
Ouarda Djaoudene, Mostapha Bachir-Bey, Connie Schisano, Sabrina Djebari, Gian Carlo Tenore, Anabela Romano
The present study aimed to evaluate the efficacy of natural deep eutectic solvents (NADESs) on the extraction of phytochemicals from eight Algerian date fruit cultivars ( Phoenix dactylifera L.). In this study, lactic acid/sucrose-based NADESs were used as an alternative to conventional chemical solvents using the ultrasound-assisted extraction (UAE) method. The obtained extracts were assessed for the determination of bioactive compound contents, phenolic composition, antioxidant activity, and enzyme inhibitory potential...
January 31, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38389741/stabilizing-bony-plate-in-guided-endodontic-surgery-using-an-innovative-approach
#30
Maulee D Sheth, Ankit V Arora, Sonali V Kapoor
Endodontic microsurgery in tandem with advanced radiographic techniques has led to the emergence of guided surgeries. Preservation of the cortical bone to enhance the healing and stabilization of tissues surrounding the tooth of concern can now be facilitated by bone cement used in the field of orthopedics. This case report details a guided endodontic surgery technique in 17 years old where a traumatic infliction leads to a phoenix abscess. The technique elaborated emphasizes on the three-dimensional printing of a surgical template with the help of cone-beam computed tomography, followed using a medical-grade bone cement in the most minimal manner to reposition the buccal cortical bone...
January 2024: J Conserv Dent Endod
https://read.qxmd.com/read/38388313/measuring-chief-resident-skill-and-entrustment-progression-in-an-operative-coaching-program-four-years-experience
#31
JOURNAL ARTICLE
Michael R Go, Amber L Traugott, Aslam Ejaz, Courtney Collins, Alan E Harzman, E Christopher Ellison, Xiaodong Phoenix Chen
OBJECTIVE: Operative coaching (OC) may facilitate improvement of surgery residents' competencies by optimizing learning and teaching. We investigated how residents' operative skills and prospective entrustment (PE) progress throughout the chief year in our OC program, how OC is perceived by participants, and how OC may facilitate learning and teaching. DESIGN, SETTING, AND PARTICIPANTS: This is a mixed-methods study conducted within the Ohio State University Wexner Medical Center General Surgery residency...
February 21, 2024: Journal of Surgical Education
https://read.qxmd.com/read/38386303/first-report-of-pitaya-virus-x-infecting-lophocereus-schottii-f-mieckleyanus-thin-stemmed-totem-pole-cactus-in-the-united-states
#32
JOURNAL ARTICLE
Neeraja Singh, Johan Manuel Murcia Bermudez, Michael Chamberland, Bindu Poudel
Lophocereus is a genus of three species of columnar cacti native to Arizona and Mexico (Lodi, 2015). These cacti produce several tall, ascending, columnar stems that branch at the base in a candelabra-like arrangement. The most common species, L. schottii is known as the senita cactus. Several unusual knobby-stemmed spineless forms of senita cactus have been found in nature in Baja California, Mexico, which are collectively known as totem pole cacti. The thin-stemmed totem pole cactus, L. schottii f. mieckleyanus is an important part of landscapes in southern Arizona...
February 22, 2024: Plant Disease
https://read.qxmd.com/read/38377678/prolonged-remission-followed-by-low-insulin-requirements-in-a-patient-with-type-1-diabetes-on-a-very-low-carbohydrate-diet
#33
JOURNAL ARTICLE
Hakan Ozoran, Phoenix Guwa, Pam Dyson, Garry D Tan, Fredrik Karpe
SUMMARY: The use of a low-carbohydrate diet (LCD) reduces insulin requirements in insulinopenic states such as type 1 diabetes mellitus (T1DM). However, the use of potentially ketogenic diets in this clinical setting is contentious and the mechanisms underlying their impact on glycaemic control are poorly understood. We report a case of a patient with a late-onset classic presentation of T1DM who adopted a very low-carbohydrate diet and completely avoided insulin therapy for 18 months, followed by tight glycaemic control on minimal insulin doses...
January 1, 2024: Endocrinology, Diabetes & Metabolism Case Reports
https://read.qxmd.com/read/38375102/multidrug-resistant-proteus-mirabilis-infections-and-clinical-outcome-at-tertiary-hospital-in-riyadh-saudi-arabia
#34
JOURNAL ARTICLE
Taghreed A Hafiz, Ghadi S Alghamdi, Zeina S Alkudmani, Ahmed S Alyami, Abeer AlMazyed, Ohoud S Alhumaidan, Murad A Mubaraki, Fawzia E Alotaibi
BACKGROUND: Proteus mirabilis ( P. mirabilis ) is known to cause various infections, most commonly urinary tract infections, and is a threat to hospitalized patients, especially in long-stay departments that utilize invasive devices. This study aims to fill the knowledge gap regarding P. mirabilis epidemiology and antimicrobial resistance in Saudi Arabia. It investigates epidemiological patterns, resistance characteristics, and clinical outcomes among P. mirabilis patients at King Fahad Medical City in Riyadh from 2019 to 2021...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38373748/phoenix-sepsis-score-redefining-paediatric-sepsis
#35
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
February 19, 2024: Archives of Disease in Childhood
https://read.qxmd.com/read/38373515/men-who-have-sex-with-men-were-more-depressed-than-their-counterparts-because-of-lower-social-support-and-higher-loneliness-a-comparative-survey-among-chinese-university-students
#36
JOURNAL ARTICLE
Luyao Xie, Phoenix K H Mo, Zixin Wang, Xiaobing Tian, Joseph T F Lau
BACKGROUND: Poor mental health is prevalent among men who have sex with men (MSM), including MSM university students (MSMUS), causing a significant burden on their health and society. The study aimed to compare the difference in levels of depressive symptoms between Chinese MSMUS and non-MSMUS and test the mediating roles of social support and loneliness in the relationship between MSM status and depressive symptoms among male university students. METHODS: From June to October 2018, a total of 305 MSMUS and 2447 non-MSMUS from two cities in Sichuan province (China) were investigated using questionnaires...
February 17, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38358640/chemical-characterization-of-phoenix-dactylifera-l-seeds-and-their-beneficial-effects-on-the-vascular-response-in-hypertensive-rats
#37
JOURNAL ARTICLE
Fredi Cifuentes, Javier Palacios, Daniel Asunción-Alvarez, Ricardo D G de Albuquerque, Mario J Simirgiotis, Adrián Paredes, Chukwuemeka R Nwokocha, Raha Orfali, Shagufta Perveen
Although Phoenix dactylifera dates are traditionally consumed for their health benefits, no research has been done on the vascular response in hypertensive animals. This study evaluated the vascular relaxation of hydroalcoholic extracts from seeds of three varieties of P. dactylifera; Sukkari seed (SS), Ajwa seed (AS), and Mabroom seed (MS) on L-NAME-induced hypertension and spontaneously hypertensive rats (SHR). Results showed that all extracts (10 µg/mL) caused relaxations higher than 60% in the aortic rings precontracted with 10- 6 M phenylephrine in normotensive rats, the SS extract was the most potent...
February 15, 2024: Plant Foods for Human Nutrition
https://read.qxmd.com/read/38354771/two-level-anterior-cervical-discectomy-and-fusion-performed-using-a-3-dimensional-exoscope
#38
Steve S Cho, Bryan S Lee
Anterior cervical discectomy and fusion (ACDF) is a common neurosurgical procedure. Portions of the procedure, such as the discectomy, foraminotomy, graft placement, and plate placement, are often performed using operating microscopes to maximize visualization and minimize neurovascular injury. Although standard operating microscopes offer superb visualization, they lack ergonomic and educational utility. With modern advancements in digital imaging and stereopsis, there has been a surge of interest in evaluating modern exoscopes for their utility in cranial and spinal neurosurgery...
February 12, 2024: World Neurosurgery
https://read.qxmd.com/read/38353870/impacts-of-vaccination-and-severe-acute-respiratory-syndrome-coronavirus-2-variants-alpha-and-delta-on-coronavirus-disease-2019-transmission-dynamics-in-four-metropolitan-areas-of-the-united-states
#39
JOURNAL ARTICLE
Abhishek Mallela, Ye Chen, Yen Ting Lin, Ely F Miller, Jacob Neumann, Zhili He, Kathryn E Nelson, Richard G Posner, William S Hlavacek
To characterize Coronavirus Disease 2019 (COVID-19) transmission dynamics in each of the metropolitan statistical areas (MSAs) surrounding Dallas, Houston, New York City, and Phoenix in 2020 and 2021, we extended a previously reported compartmental model accounting for effects of multiple distinct periods of non-pharmaceutical interventions by adding consideration of vaccination and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variants Alpha (lineage B.1.1.7) and Delta (lineage B.1.617.2). For each MSA, we found region-specific parameterizations of the model using daily reports of new COVID-19 cases available from January 21, 2020 to October 31, 2021...
February 14, 2024: Bulletin of Mathematical Biology
https://read.qxmd.com/read/38348286/the-dcm-project-portal-a-direct-to-participant-platform-of-the-dcm-research-project
#40
JOURNAL ARTICLE
Elizabeth S Jordan, Phoenix L Grover, Jay Lin, Carl A Starkey, Elizabeth A Finley, Hanyu Ni, Ray E Hershberger
STUDY OBJECTIVE: To develop a digital platform to conduct family-based, dilated cardiomyopathy (DCM) genetic research. DESIGN: The DCM Project Portal, a direct-to-participant electronic recruitment, consent, and communication tool, was designed using prior experience with traditional enrollment methods and characteristics and feedback of current participants. PARTICIPANTS: DCM patients (probands) and their family members enrolled from June 7, 2016 to March 15, 2020 at 25 US advanced heart failure programs...
February 2024: American heart journal plus: cardiology research and practice
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