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REVIEW
Bibi Zeyah Fatemah Sairally, Rima K Dhillon-Smith, Geetu Jethwani, Pallavi Latthe
BACKGROUND: Polycystic ovary syndrome (PCOS) treatment in adolescents currently focuses on lifestyle interventions, with pharmacological treatment options often limited to hormonal contraceptives. Several of these carry broad side-effect profiles and are not always accepted by young girls. There is growing interest in non-hormonal therapies for PCOS. We aimed to collate the evidence on the use of myoinositol or D-chiro-inositol in the improvement of PCOS symptoms in symptomatic adolescents...
February 26, 2024: Journal of Pediatric Endocrinology & Metabolism: JPEM
#22
JOURNAL ARTICLE
Kensaku Endo, Shun Hashiyada, Tetsuya Narushima, Yoshihiko Togawa, Hiromi Okamoto
Circular dichroism (CD) spectra for pseudo-two-dimensional chiral nanomaterials were systematically investigated and analyzed in relation to the rotational symmetry of the nanomaterials. Theoretically, an ideal two-dimensional chiral matter is CD inactive for light incident normal to the plane if it possesses threefold or higher rotational symmetry. If the matter has two- or onefold rotational symmetry, it should exhibit CD activity, and the CD signal measured from the back side of the matter is expected to be inverted from that measured from the front side...
December 21, 2023: Journal of Chemical Physics
#23
JOURNAL ARTICLE
Juan Antonio Cordero-Varela, Marta Reyes-Corral, Miguel Lao-Pérez, Beatriz Fernández-Santos, Fernando Montenegro-Elvira, Lluis Sempere, Patricia Ybot-González
Adequate nutrient supply is crucial for the proper development of the embryo. Although nutrient supply is determined by maternal diet, the gut microbiota also influences nutrient availability. While currently there is no cure for neural tube defects (NTDs), their prevention is largely amenable to maternal folic acid and inositol supplementation. The gut microbiota also contributes to the production of these nutrients, which are absorbed by the host, but its role in this context remains largely unexplored. In this study, we performed a functional and morphological analysis of the intestinal tract of loop-tail mice ( Vangl2 mutants), a mouse model of folate/inositol-resistant NTDs...
November 28, 2023: Nutrients
#24
JOURNAL ARTICLE
Habtamu Geremew, Fekadu Abera Kebede, Abraham Negash, Misganaw Asmamaw Mengstie, Demeke Geremew
INTRODUCTION: Despite its deleterious consequences, khat chewing is escalating worldwide. However, there is a lack of evidence about the extent of khat chewing among pregnant women in Ethiopia, particularly in the current study area. Therefore, this study aimed to assess the prevalence of current khat chewing and its associated factors among pregnant women in Chiro district, eastern Ethiopia. METHODS: This community-based cross-sectional study was conducted in Chiro district from November 1 to 30, 2022 G...
2023: Frontiers in Psychiatry
#25
JOURNAL ARTICLE
Cristina Tortolini, Valeria Gigli, Flavio Rizzo, Andrea Lenzi, Mariano Bizzarri, Antonio Angeloni, Riccarda Antiochia
This paper describes the development of a simple voltammetric biosensor for the stereoselective discrimination of myo-inositol (myo-Ins) and D-chiro-inositol (D-chiro-Ins) by means of bovine serum albumin (BSA) adsorption onto a multi-walled carbon nanotube (MWCNT) graphite screen-printed electrode (MWCNT-GSPE), previously functionalized by the electropolymerization of methylene blue (MB). After a morphological characterization, the enantioselective biosensor platform was electrochemically characterized after each modification step by differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS)...
November 16, 2023: Sensors
#26
JOURNAL ARTICLE
Valerio Giuso, Christophe Gourlaouen, Mathias Delporte-Pébay, Thomas Groizard, Nicolas Vanthuyne, Jeanne Crassous, Chantal Daniel, Matteo Mauro
The design of enantiomerically pure circularly polarized luminescent (CPL) emitters would enormously benefit from the accurate and in-depth interpretation of the chiroptical properties by means of jointly (chiroptical) photophysical measurements and state-of-the-art theoretical investigation. Herein, computed and experimental (chiro-)optical properties of a series of eight enantiopure phosphorescent rhenium(I) tricarbonyl complexes are systematically compared in terms of electronic circular dichroism (ECD) and CPL...
November 23, 2023: Physical Chemistry Chemical Physics: PCCP
#27
JOURNAL ARTICLE
Harrison Chiro Ugwuoroko, George Uchenna Eleje, Chigozie Geoffrey Okafor, Zebulon Chiawolamoke Okechukwu, Ahizechukwu Chigoziem Eke, Chukwuemeka Chukwubuikem Okoro, Lazarus Ugochukwu Okafor, Chidinma Charity Okafor, Chukwudi Anthony Ogabido, Tobechi Kingsley Njoku, Chukwudubem Chinagorom Onyejiaka, Adanna Vivian Egwim, Hillary Ikechukwu Obiagwu, JohnBosco Emmanuel Mamah, Chinedu Lawrence Olisa, Nnanyerugo Livinus Onah, Gerald Okanandu Udigwe
BACKGROUND: Induction of labour has remained one of the most valuable interventions in obstetric practice. Over the years, the proportion of women undergoing induction of labour (IOL) has been on a steady increase. The significance to obstetrics practice as well as its maternal and perinatal outcomes are sacrosanct, hence the need for its periodic review. OBJECTIVE: To determine the obstetric outcomes of induction of labour. METHODS: A five-year retrospective study of all cases of induction of labour at the maternity unit of Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, Nigeria between January 1st 2017 and 31st December 2021...
July 8, 2023: International journal of innovative research in medical science
#28
JOURNAL ARTICLE
Laura Scarpetta-Pizo, Ricardo Venegas, Pablo Barrias, Karina Muñoz-Becerra, Nayareth Vilches-Labbé, Francisco Mura, Ana María Méndez-Torres, Rodrigo Ramírez-Tagle, Alejandro Toro-Labbé, Samuel Hevia, José H Zagal, Rubén Oñate, Alexis Aspee, Ingrid Ponce
The chiral-induced spin selectivity effect (CISS) is a breakthrough phenomenon that has revolutionized the field of electrocatalysis. We report the first study on the electron spin-dependent electrocatalysis for the oxygen reduction reaction, ORR, using iron phthalocyanine, FePc, a well-known molecular catalyst for this reaction. The FePc complex belongs to the non-precious catalysts group, whose active site, FeN4, emulates catalytic centers of biocatalysts such as Cytochrome C. This study presents an experimental platform involving FePc self-assembled to a gold electrode surface using chiral peptides (L and D enantiomers), i...
November 12, 2023: Angewandte Chemie
#29
REVIEW
Andrea Etrusco, Antonio Simone Laganà, Vito Chiantera, Giovanni Buzzaccarini, Vittorio Unfer
Inositols are insulin-sensitizing compounds of promising efficacy in the management of polycystic ovary syndrome (PCOS). On the one hand, myo-inositol (myo-ins) plays a regulatory role in male and female reproductive function, influencing the development of oocytes, spermatozoa, and embryos. On the other hand, high concentrations of D-chiro-inositol (D-chiro-ins) in the ovary may adversely affect oocyte quality. This review analyses the available literature, which encourages the clinical use of myo-ins in assisted reproductive technologies (ARTs) due to its beneficial effects on female and male reproduction...
January 2024: Trends in Endocrinology and Metabolism: TEM
#30
JOURNAL ARTICLE
Junsuke Yamanishi, Hyo-Yong Ahn, Hiromi Okamoto
Nanoscopic observation of chiro-optical phenomena is essential in wide scientific areas but has measurement difficulties; hence, its physics is still unknown. To obtain a full understanding of the physics of chiro-optical systems and derive the full potentials, it is essential to perform an in situ observation of the chiro-optical effect from the individual parts because the macroscopic chiro-optical effect cannot be translated directly into microscopic effects. In the present study, we observed the chiro-optical responses at the nanoscale level by detecting the chiro-optical forces, which were generated by illumination of the material-probe system with circularly polarized light...
October 4, 2023: Nano Letters
#31
JOURNAL ARTICLE
Kouhei Nishikawa, Ryosuke Kuroiwa, Jun Tamogami, Masashi Unno, Tomotsumi Fujisawa
Raman optical activity (ROA) spectroscopy was used to study the conformation of the retinal chromophore in sensory rhodopsin II (SRII), which is a blue-green light sensor of microbes. The ROA spectrum consisted of the negative vibrational bands of the chromophore, whose relative intensities are similar to those of the parent Raman spectrum. This spectral feature was explained by the left-handed helical twist of the retinal chromophore on the basis of quantum chemical calculations. On the other hand, we found that the chromophore conformation based on the crystal structures of SRII has a right-handed helical twist, which does not agree with the observation...
August 9, 2023: Journal of Physical Chemistry. B
#32
JOURNAL ARTICLE
Chirality Versus Symmetry: Electron's Spin Selectivity in Non-Polar Chiral Lead-Bromide Perovskites.
Alexandre Abhervé, Nicolas Mercier, Anil Kumar, Tapan Kumar Das, Jacky Even, Claudine Katan, Mikaël Kepenekian
In the last decade, chirality-induced spin selectivity (CISS), the spin-selective electron transport through chiral molecules, has been described in a large range of materials, from insulators to superconductors. Because more experimental studies are desired for the theoretical understanding of the CISS effect, chiral metal-halide semiconductors may contribute to the field thanks to their chiroptical and spintronic properties. In this regard, we use new chiral organic cations S-HP1A and R-HP1A (HP1A = 2-hydroxy-propyl-1-ammonium) to prepare two-dimensional (2D) chiral halide perovskites (HPs) which crystallize in the enantiomorphic space groups P43 21 2 and P41 21 2, respectively...
August 1, 2023: Advanced Materials
#33
JOURNAL ARTICLE
Yan Wang, Ya-Xin Li, Liliana Cseh, Yong-Xuan Chen, Shu-Gui Yang, Xiangbing Zeng, Feng Liu, Wenbing Hu, Goran Ungar
The recently discovered orthorhombic liquid crystal (LC) phase of symmetry Fddd is proving to be widespread. In this work, a chiral hydroxybutyrate linkage is inserted into the molecular core of hexacatenar rodlike compounds, containing a thienylfluorenone fluorophore. In addition to more usual tools, the methods used include grazing-incidence X-ray scattering, modulated differential scanning calorimetry (DSC), flash DSC with rates up to 6000 K/s, and chiro-optical spectroscopies using Mueller matrix method, plus conformational mapping...
July 31, 2023: Journal of the American Chemical Society
#34
JOURNAL ARTICLE
Lokeshwaran Manoharan, Bodil Roth, Corinna Bang, Hans Stenlund, Bodil Ohlsson
Dietary interventions modify gut microbiota and clinical outcomes. Weight reduction and improved glucose and lipid homeostasis were observed after adopting an Okinawan-based Nordic diet (O-BN) in individuals with type 2 diabetes. The aim of the present study was to explore changes in metabolomics and gut microbiota during O-BN and correlate changes with clinical outcomes. A total of 30 patients (17 women), aged 57.5 ± 8.2 years, diabetes duration 10.4 ± 7.6 years, 90% over-weight, were included. Participants were provided an O-BN for 12 weeks...
July 24, 2023: Nutrients
#35
JOURNAL ARTICLE
Sabrina Basciani, Maurizio Nordio, Simona Dinicola, Vittorio Unfer, Lucio Gnessi
The primary control of dysmetabolic patients is extremely challenging worldwide, with inadequate dietary habits and sporadic physical activity among the key risk factors for metabolic syndrome onset. Nowadays, there is no exclusive treatment for this condition, and considering that preventive measures usually fail, new therapeutic approaches need to be proposed and investigated. This present pilot study compared the effects of diet alone and in association with a combination of myo-inositol and d-chiro-inositol in their 40:1 ratio, α-lactalbumin, and Gymnema sylvestre on different metabolic parameters in obese dysmetabolic patients...
July 14, 2023: Nutrients
#36
REVIEW
George Uchenna Eleje, Olabisi Morebise Loto, Hadiza Abdullahi Usman, Chinyere Ukamaka Onubogu, Preye Owen Fiebai, Godwin Otuodichinma Akaba, Ayyuba Rabiu, Ikechukwu Innocent Mbachu, Moriam Taiwo Chibuzor, Rebecca Chinyelu Chukwuanukwu, Ngozi Nneka Joe-Ikechebelu, Emeka Philip Igbodike, Richard Obinwanne Egeonu, Ijeoma Chioma Oppah, Uchenna Chukwunonso Ogwaluonye, Chike Henry Nwankwo, Stephen Okoroafor Kalu, Chisom God'swill Chigbo, Chukwuanugo Nkemakonam Ogbuagu, Shirley Nneka Chukwurah, Chinwe Elizabeth Uzochukwu, Aishat Ahmed, Chiamaka Henrietta Jibuaku, Samuel Oluwagbenga Inuyomi, Bukola Abimbola Adesoji, Ubong Inyang Anyang, Ekene Agatha Emeka, Odion Emmanuel Igue, Ogbonna Dennis Okoro, Prince Ogbonnia Aja, Chiamaka Perpetua Chidozie, Hadiza Sani Ibrahim, Fatima Ele Aliyu, Harrison Chiro Ugwuoroko, Aisha Ismaila Numan, Solace Amechi Omoruyi, Osita Samuel Umeononihu, Chukwuemeka Chukwubuikem Okoro, Ifeanyi Kingsley Nwaeju, Arinze Anthony Onwuegbuna, Lydia Ijeoma Eleje, David Chibuike Ikwuka, Eric Okechukwu Umeh, Sussan Ifeyinwa Nweje, Ifeoma Clara Ajuba, Angela Ogechukwu Ugwu, Uzoamaka Rufina Ebubedike, Divinefavour Echezona Malachy, Chigozie Geoffrey Okafor, Nnaedozie Paul Obiegbu, Emmanuel Onyebuchi Ugwu, Ibrahim Adamu Yakasai, Oliver Chukwujekwu Ezechi, Joseph Ifeanyichukwu Ikechebelu
OBJECTIVE: We systematically identified the prevalence of triplex infections (combined human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV)) in pregnancy. METHODS: To gather information on the frequency of triplex infections, we searched the databases of PubMed, CINAHL, and Google Scholar. Without regard to language, we utilized search terms that covered HIV, HBV, HCV, and pregnancy. Pregnant women with triplex infections of HIV, HBV, and HCV were included in studies that also examined the prevalence of triplex infections...
2023: Obstetrics and Gynecology International
#37
JOURNAL ARTICLE
Dielectric chiral metasurfaces for enhanced circular dichroism spectroscopy at near infrared regime.
Asif Ali, Hafiz Saad Khaliq, Aqsa Asad, Jehan Akbar, Muhammad Zubair, Muhammad Qasim Mehmood, Yehia Massoud
Numerous applications of chiro-optical effects can be found in nanophotonics, including imaging and spin-selective absorption, particularly in sensing for separating and detecting chiral enantiomers. Flat single-layer metasurfaces composed of chiral or achiral sub-wavelength structures offer unique properties to manipulate the light due to their extraordinary light-matter interaction. However, at optical wavelengths, the generation of strong chirality is found to be challenging via conventional chiral metasurface approaches...
July 7, 2023: RSC Advances
#38
JOURNAL ARTICLE
Xinxin Liu, Chuan He, Tomoyuki Koyama
A natural sugar alcohol, D-pinitol, has been reported to be a potential compound for osteoporosis treatment via inhibiting osteoclastgenesis. However, research on the effects of pinitol on osteoporosis in vivo is still limited. The present study investigated the protective effects of pinitol on ovariectomized mice and attempted to elucidate this mechanism in vivo. Four-week-old female ovariectomized ICR mice were employed as a postmenopausal osteoporosis model and treated with pinitol or estradiol (E2) for 7 wk...
2023: Journal of Nutritional Science and Vitaminology
#39
JOURNAL ARTICLE
Giuseppina Porcaro, Gabriele Bilotta, Elena Capoccia, Maria Salomé Bezerra Espinola, Cesare Aragona
Endometrial hyperplasia is a threatening pathology driven by unopposed estrogen stimulus. Moreover, insulin may act on the endometrium, prompting further growth. We aimed at assessing whether D-chiro-Inositol, an insulin sensitizer with estrogen-lowering properties, might improve the condition of patients with simple endometrial hyperplasia without atypia. We enrolled women with simple endometrial hyperplasia without atypia and related symptoms, including abnormal uterine bleeding. We treated the patients with one tablet per day, containing 600 mg of D-chiro-inositol for six months...
June 13, 2023: International Journal of Molecular Sciences
#40
RANDOMIZED CONTROLLED TRIAL
Roshan Nazirudeen, Subbiah Sridhar, Raghavendran Priyanka, Baskaran Sumathi, Vasanthiy Natarajan, Eagappan Subbiah, Kasthuri Santharam Raghavan, Jayaraman Sangumani
OBJECTIVE: Insulin resistance and hyperinsulinemia plays an important role in pathogenesis of polycystic ovary syndrome (PCOS). Metformin, Myoinositol and d-chiro-inositol acts as insulin sensitizers and exerts a beneficial effects in PCOS. The objective is to compare the effect of metformin monotherapy versus a combination of metformin with Myoinositol and d-chiro-inositol in PCOS. DESIGN: This study is a randomized controlled trial conducted over a period of 6 months...
August 2023: Clinical Endocrinology
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