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https://www.readbyqxmd.com/read/29042448/myo-inositol-effects-in-women-with-pcos-a-meta-analysis-of-randomized-controlled-trials
#1
Vittorio Unfer, Fabio Facchinetti, Beatrice Orrù, Barbara Giordani, John Nestler
Myo-inositol (MI) supplementation in women with polycystic ovary syndrome (PCOS) has been evaluated over the last years. Many hormonal and reproductive impairments associated with this disorder seem relieved by the supplement. The objective of the meta-analysis was to assess the effects of MI alone or combined with d-chiro-inositol (DCI) on the endocrine and metabolic abnormalities of women with PCOS. Literature was retrieved from selected databases, MEDLINE, EMBASE, PubMed and Research Gate (up to November 2016)...
November 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28982033/d-chiro-inositol-phosphoglycans-in-preeclampsia-where-are-we-where-are-we-going
#2
REVIEW
Marco Scioscia
Preeclampsia results from a complex interaction between immunological alterations, endothelial dysfunction, and insulin resistance. Inositol second messengers are known to be involved in metabolic signaling and are highly expressed during preeclampsia. In the past two decades, several studies were published on different aspects where these molecules are involved. It appears that maternal increase of IPG-P content in all tissues and fluids reflects an increased production of inositol mediators on the fetal side in preeclampsia...
September 28, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28884384/study-of-chir-function-in-serratia-marcescens-and-its-application-for-improving-2-3-butanediol-from-crystal-chitin
#3
Qiang Yan, Eunsoo Hong, Stephen S Fong
Microbial utilization of chitin, a potential renewable biomass feedstock, is being pursued as a means of developing novel consolidated bioprocessing for the production of chemicals. Serratia marcescens is a gram-negative bacterium that is known for its chitinolytic capability and as a native 2,3-butanediol producer. In S. marcescens, ChiR has been suggested to be a positive regulator of chitinase production. In this study, we aim to understand the effect of ChiR in regulating nine chitinase-related genes in S...
September 8, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28805750/inositol-derivatives-and-phenolic-compounds-from-the-roots-of-taraxacum-coreanum
#4
Eun Jin Mo, Jong Hoon Ahn, Yang Hee Jo, Seon Beom Kim, Bang Yeon Hwang, Mi Kyeong Lee
In this study, the characterization of chemical constituents and biological activity of the roots of Taraxacum coreanum (Asteraceae) was attempted. Phytochemical investigation of the roots of T. coreanum led to the isolation of two new inositol derivatives, taraxinositols A (1) and B (2), and a new phenolic compound, taraxinol (16), together with twenty known compounds including four inositol derivatives, neo-inositol-1,4-bis (4-hydroxybenzeneacetate) (3), chiro-inositol-1,5-bis(4- hydroxybenzeneacetate) (4), chiro-inositol-2,3-bis (4-hydroxybenzeneacetate) (5) and chiro-inositol- 1,2,3-tris (4-hydroxybenzeneacetate) (6), nine phenolic compounds: p-hydroxybenzaldehyde (7), vanillin (8), syringaldehyde (9), vanillic acid (10), 4-methoxyphenylacetic acid (11), 4-hydroxy- phenylacetic acid methyl ester (12), optivanin (13), isoferulic acid (14) and dihydroconiferyl alcohol (15), four coumarins: nodakenetin (17), decursinol (18), prangol (19) and isobyakangelicin (20), and three lignans: syringaresinol-4'-O-β-d-glucoside (21), syringaresinol (22), and pinoresinol (23)...
August 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28804631/the-influence-of-d-chiro-inositol-and-d-myo-inositol-in-pregnant-women-with-glucose-intolerance
#5
Domenico Dell'Edera, Francesca Sarlo, Arianna Allegretti, Francesca Simone, Maria Giovanna Lupo, Annunziata Anna Epifania
The aim of the present study was to demonstrate that the use of inositol and folic acid from the first trimester of pregnancy, counteracts the onset of gestational diabetes mellitus (GDM) in women at risk, preserving the infants from macrosomia, hypoglycemia and preterm delivery. The authors collected data from the pregnant women at the laboratory (Unit of Cytogenic and Molecular Genetics), from January 2014 to April 2016, all with first trimester fasting plasma glucose (FPG) >92 mg/dl. A total of 40 women were treated with 250 mg/day D-chiro-inositol, 1...
August 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28795713/circularly-polarized-laser-emission-in-optically-active-organic-dye-solutions
#6
Luis Cerdán, Florencio Moreno, Mizuki Johnson, Gilles Muller, Santiago de la Moya, Inmaculada García-Moreno
The generation of circularly polarized laser emission (CPLE) in photonic devices has attracted increasing attention due to the prospects of using CP light in displaying technologies or advanced microscopies. Organic systems excel as laser materials across the whole visible spectrum, and despite many of them displaying circularly polarized luminescence (CPL), none have been shown thus far to amplify their own CPL, let alone generate CPLE. Consequently, there is still a need to find alternative CPLE organic devices...
August 23, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28770950/prevention-of-neural-tube-defects-and-maternal-gestational-diabetes-through-the-inositol-supplementation-preliminary-results
#7
D Dell'Edera, F Sarlo, A Allegretti, A A Epifania, F Simone, M G Lupo, M Benedetto, M R D'Apice, A Capalbo
OBJECTIVE: Our study aims to demonstrate that the use in the preconceptional period until the 24th week of pregnancy of inositol and folic acid, first of all, preserves the product of conception from neural tube defects (NTDs) and then, thanks to inositol supplementation, it possibly counteracts and prevents the onset of maternal gestational diabetes (GDM). PATIENTS AND METHODS: We have collected data derived from pregnant women arrived at our laboratory, from January 2014 to January 2016, with no family history of type 2 diabetes and hypertension...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28756130/inositol-supplementation-in-women-with-polycystic-ovary-syndrome-undergoing-intracytoplasmic-sperm-injection-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#8
REVIEW
Nicolás Mendoza, Laura Pérez, Tommaso Simoncini, Alessandro Genazzani
Polycystic ovary syndrome (PCOS) is a complex and heterogeneous disease that involves menstrual dysfunction and reproductive difficulty, as well as metabolic problems. The aim of this study was to assess the effectiveness of myo-inositol (MYO) and d-chiro-inositol (DCI) on improving oocyte or embryo quality and pregnancy rates for women with PCOS undergoing intracytoplasmic sperm injection (ICSI). We searched the Web of Knowledge, MEDLINE, EMBASE, Pubmed, Scopus and Cochrane databases for all articles published in any language up to March 2017...
July 14, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28752910/antioxidants-for-female-subfertility
#9
REVIEW
Marian G Showell, Rebecca Mackenzie-Proctor, Vanessa Jordan, Roger J Hart
BACKGROUND: A couple may be considered to have fertility problems if they have been trying to conceive for over a year with no success. This may affect up to a quarter of all couples planning a child. It is estimated that for 40% to 50% of couples, subfertility may result from factors affecting women. Antioxidants are thought to reduce the oxidative stress brought on by these conditions. Currently, limited evidence suggests that antioxidants improve fertility, and trials have explored this area with varied results...
July 28, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28748913/d-chiro-inositol-effectively-attenuates-cholestasis-in-bile-duct-ligated-rats-by-improving-bile-acid-secretion-and-attenuating-oxidative-stress
#10
Shuang-Shuang Zhao, Na-Ren Li, Wu-Li Zhao, Hong Liu, Mao-Xu Ge, Yi-Xuan Zhang, Long-Yin Zhao, Xue-Fu You, Hong-Wei He, Rong-Guang Shao
Cholestatic liver diseases are important causes of liver cirrhosis and liver transplantation, but few drugs are available for treatment. D-chiro-inositol (DCI), an isomer of inositol found in many Leguminosae plants and in animal viscera, is used clinically for the treatment of polycystic ovary syndrome (PCOS) and diabetes mellitus. In this study, we investigated whether DCI exerted an anti-cholestatic effect and its underlying mechanisms. A cholestatic rat model was established via bile duct ligation (BDL)...
July 27, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28737286/unexpected-chiro-thermoresponsive-behavior-of-helical-poly-phenylacetylene-s-bearing-elastin-based-side-chains
#11
Sandra Arias, Felix Freire, Marcelo Calderón, Julian Bergueiro
The thermoresponsive behavior of an elastin-based polymer can be altered by the polymeric macromolecular conformation. Thus, when the elastin basic amino acid sequence VPGVG is used as a pendant group of a poly(phenylacetylene) (PPA) its thermoresponsive behavior in water can be remotely detected through conformational changes on the formed helix. Circular dichroism at different temperatures shows an inversion of the first Cotton effect (450 nm) at 25.8 °C that matches with the cloud point temperature...
September 11, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28724181/finding-the-best-therapeutic-approach-for-pcos-the-importance-of-inositol-s-bioavailability
#12
B Orrù, R Circo, P Logoteta, S Petousis, G Carlomagno
Broadening clinical evidence has markedly designated inositol(s) as a common and effective therapeutic approach for PCOS and infertility. Although considerable research has been focused on the use in clinical practice of myo-inositol (myo-ins) and D-chiro-inositol (D-chiro-ins), the two major inositol stereoisomers, less attention has been paid to their bioavailability. Therefore, the aim of this paper is to gather and analyze information on inositol(s) bioavailability, to better delineate its optimal concentration for scientific and clinical purposes...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28714347/antifungal-activities-and-active-ingredients-of-melodinus-suaveolens-champ-ex-benth
#13
Yanan Xu, Siquan Ling, Dongqiang Zeng, Wenwei Tang
Four Melodinus species with antifungal activity were found in survey of the floral resources, in Shiwan Mountain Natural Reserve, Guangxi Province, China. Crude methanolic extracts of the twigs and leaves of Melodinus suaveolens exhibited potent antifungal activities against the plant pathogenic fungi Colletotrichum musae, Colletotrichum graminicola, Colletotrichum gloeosporioides and Alternaria musae, and the ethyl acetate fraction inhibited these pathogens at rates of 85.37, 91.47, 72.77 and 89.87%, respectively (5 mg/mL)...
July 16, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28693424/bacillus-subtilis-iolq-dega-is-a-transcriptional-repressor-of-iolx-encoding-nad-dependent-scyllo-inositol-dehydrogenase
#14
Dong-Min Kang, Christophe Michon, Tetsuro Morinaga, Kosei Tanaka, Shinji Takenaka, Shu Ishikawa, Ken-Ichi Yoshida
BACKGROUND: Bacillus subtilis is able to utilize at least three inositol stereoisomers as carbon sources, myo-, scyllo-, and D-chiro-inositol (MI, SI, and DCI, respectively). NAD(+)-dependent SI dehydrogenase responsible for SI catabolism is encoded by iolX. Even in the absence of functional iolX, the presence of SI or MI in the growth medium was found to induce the transcription of iolX through an unknown mechanism. RESULTS: Immediately upstream of iolX, there is an operon that encodes two genes, yisR and iolQ (formerly known as degA), each of which could encode a transcriptional regulator...
July 11, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28642705/polycystic-ovary-syndrome-insights-into-the-therapeutic-approach-with-inositols
#15
REVIEW
Maria A Sortino, Salvatore Salomone, Michele O Carruba, Filippo Drago
Polycystic ovary syndrome (PCOS) is characterized by hormonal abnormalities that cause menstrual irregularity and reduce ovulation rate and fertility, associated to insulin resistance. Myo-inositol (cis-1,2,3,5-trans-4,6-cyclohexanehexol, MI) and D-chiro-inositol (cis-1,2,4-trans-3,5,6-cyclohexanehexol, DCI) represent promising treatments for PCOS, having shown some therapeutic benefits without substantial side effects. Because the use of inositols for treating PCOS is widespread, a deep understanding of this treatment option is needed, both in terms of potential mechanisms and efficacy...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28544572/inositol-treatment-of-anovulation-in-women-with-polycystic-ovary-syndrome-a-meta-analysis-of-randomised-trials
#16
REVIEW
J Pundir, D Psaroudakis, P Savnur, P Bhide, L Sabatini, H Teede, A Coomarasamy, S Thangaratinam
Polycystic ovary syndrome is a common cause of anovulation and infertility, and a risk factor for development of metabolic syndrome and endometrial cancer. Systematic review and meta-analysis of randomised controlled trials (RCT) that evaluated the effects of inositol as an ovulation induction agent. We searched MEDLINE, EMBASE, Cochrane and ISI conference proceedings, Register and Meta-register for RCT and WHO trials' search portal. We included studies that compared inositol with placebo or other ovulation induction agents...
May 24, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28501026/metabolically-speaking-possible-reasons-behind-the-tolerance-of-sugar-belle-mandarin-hybrid-to-huanglongbing
#17
Nabil Killiny, Maria Filomena Valim, Shelley E Jones, Ahmad A Omar, Faraj Hijaz, Fred G Gmitter, Jude W Grosser
Huanglongbing (HLB) is currently considered the most destructive disease of citrus. Since its spread to the Americas, HLB has killed millions of trees and caused a sharp decline in production in many citrus growing regions. With the continuous spread of HLB disease in Florida and worldwide, there is an urgent need for the development of commercial citrus cultivars with a strong tolerance to HLB. Interestingly, field observations showed that some of the recently released mandarin hybrids such as 'Sugar Belle' were tolerant to HLB...
May 4, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28452458/chiro-optical-modulation-for-nurr1-production-from-stem-cells
#18
Madhumita Patel, Hyo Jung Moon, Ja Hye Hong, Byeongmoon Jeong
Nuclear receptor related 1 (NURR1) is an essential protein for maintenance of dopaminergic neurons in adult midbrain of which deficiency leads to Parkinson's disease. To enhance the NURR1 production of neural cells, various approaches are under investigation. Here we report that NURR1 is highly expressed in stem cells by exposure to an L-polarized blue light emitting diode (LED). Compared to stem cells cultured in the absence of a LED, under polarized green and red LEDs, the stem cells exposed to a polarized blue LED significantly enhanced neuronal biomarkers such as neurofilament M (NFM) and neuron specific enolase (NSE) at both mRNA and protein levels...
May 2, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28398738/au10-sg-10-a-chiral-gold-catenane-nanocluster-with-zero-confined-electrons-optical-properties-and-first-principles-theoretical-analysis
#19
Franck Bertorelle, Isabelle Russier-Antoine, Nathalie Calin, Clothilde Comby-Zerbino, Amina Bensalah-Ledoux, Stephan Guy, Philippe Dugourd, Pierre-François Brevet, Željka Sanader, Marjan Krstić, Vlasta Bonačić-Koutecký, Rodolphe Antoine
We report facile synthesis of the Au10(SG)10 nanoclusters, where SG stands for glutathione, found to be promising as a new class of radiosensitizers for cancer radiotherapy. The homoleptic catenane structure with two Au5SG5 interconnected rings, among different isomer structures, gives the best agreement between theoretical and experimental optical spectra and XRD patterns. This catenane structure exhibits a centrosymmetry-broken structure, resulting in enhanced second harmonic response and new characteristic circular dichroism signals in the spectral region of 250-400 nm...
May 4, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28325784/the-prevention-of-gestational-diabetes-mellitus-with-antenatal-oral-inositol-supplementation-a-randomized-controlled-trial
#20
Maria Farren, Niamh Daly, Aoife McKeating, Brendan Kinsley, Michael J Turner, Sean Daly
OBJECTIVE: This study investigated if inositol in a combination of myo-inositol and D-chiro-inositol would prevent gestational diabetes mellitus (GDM) in women with a family history of diabetes. RESEARCH DESIGN AND METHODS: This was a randomized controlled trial that examined whether inositol from the first antenatal visit prevents GDM. The trial was carried out in a single-center tertiary referral center. Women with a family history of diabetes were enrolled at the first antenatal visit...
June 2017: Diabetes Care
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