keyword
https://read.qxmd.com/read/38474162/microbiota-tryptophan-and-aryl-hydrocarbon-receptors-as-the-target-triad-in-parkinson-s-disease-a-narrative-review
#21
REVIEW
Paulina Iwaniak, Maja Owe-Larsson, Ewa M Urbańska
In the era of a steadily increasing lifespan, neurodegenerative diseases among the elderly present a significant therapeutic and socio-economic challenge. A properly balanced diet and microbiome diversity have been receiving increasing attention as targets for therapeutic interventions in neurodegeneration. Microbiota may affect cognitive function, neuronal survival and death, and gut dysbiosis was identified in Parkinson's disease (PD). Tryptophan (Trp), an essential amino acid, is degraded by microbiota and hosts numerous compounds with immune- and neuromodulating properties...
March 2, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38471271/exploring-the-gut-microbiota-and-its-potential-as-a-biomarker-in-gliomas
#22
REVIEW
Dana Aljarrah, Naima Chalour, Amine Zorgani, Tracy Nissan, Md Zahidul I Pranjol
Gut microbiome alterations are associated with various cancers including brain tumours such as glioma and glioblastoma. The gut communicates with the brain via a bidirectional pathway known as the gut-brain axis (GBA) which is essential for maintaining homeostasis. The gut microbiota produces many metabolites including short chain fatty acids (SCFAs) and essential amino acids such as glutamate, glutamine, arginine and tryptophan. Through the modulation of these metabolites the gut microbiome is able to regulate several functions of brain cells, immune cells and tumour cells including DNA methylation, mitochondrial function, the aryl hydrocarbon receptor (AhR), T-cell proliferation, autophagy and even apoptosis...
March 11, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38470516/chronic-pain-related-cognitive-deficits-preclinical-insights-into-molecular-cellular-and-circuit-mechanisms
#23
REVIEW
Siyi Han, Jie Wang, Wen Zhang, Xuebi Tian
Cognitive impairment is a common comorbidity of chronic pain, significantly disrupting patients' quality of life. Despite this comorbidity being clinically recognized, the underlying neuropathological mechanisms remain unclear. Recent preclinical studies have focused on the fundamental mechanisms underlying the coexistence of chronic pain and cognitive decline. Pain chronification is accompanied by structural and functional changes in the neural substrate of cognition. Based on the developments in electrophysiology and optogenetics/chemogenetics, we summarized the relevant neural circuits involved in pain-induced cognitive impairment, as well as changes in connectivity and function in brain regions...
March 12, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38467533/gender-specific-insights-into-the-irritable-bowel-syndrome-pathophysiology-focus-on-gut-dysbiosis-and-permeability
#24
REVIEW
Jerlin Stephy JohnBritto, Agostino Di Ciaula, Antonino Noto, Velia Cassano, Angela Sciacqua, Mohamad Khalil, Piero Portincasa, Leonilde Bonfrate
Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disorder involving the brain-gut interaction. IBS is characterized by persistent abdominal pain and changes in bowel habits. IBS exerts significant impacts on quality of life and imposes huge economic costs. Global epidemiological data reveal variations in IBS prevalence, both globally and between genders, necessitating comprehensive studies to uncover potential societal and cultural influences. While the exact pathophysiology of IBS remains incompletely understood, the mechanism involves a dysregulation of the brain-gut axis, leading to disturbed intestinal motility, local inflammation, altered intestinal permeability, visceral sensitivity, and gut microbiota composition...
March 10, 2024: European Journal of Internal Medicine
https://read.qxmd.com/read/38467381/the-emergence-of-inflammatory-microglia-during-gut-inflammation-is-not-affected-by-ffar2-expression-in-intestinal-epithelial-cells-or-peripheral-leukocytes
#25
JOURNAL ARTICLE
Maria Elisa Caetano-Silva, Laurie Rund, Mario Vailati-Riboni, Stephanie Matt, Katiria Soto-Diaz, Jon Beever, Jacob M Allen, Jeffrey A Woods, Andrew J Steelman, Rodney W Johnson
Gut inflammation can trigger neuroinflammation and is linked to mood disorders. Microbiota-derived short-chain fatty acids (SCFAs) can modulate microglia, yet the mechanism remains elusive. Since microglia do not express free-fatty acid receptor (FFAR)2, but intestinal epithelial cells (IEC) and peripheral myeloid cells do, we hypothesized that SCFA-mediated FFAR2 activation within the gut or peripheral leukocytes may impact microglia inflammation. To test this hypothesis, we developed a tamoxifen-inducible conditional knockout mouse model targeting FFAR2 exclusively on IEC and induced intestinal inflammation with dextran sodium sulfate (DSS), a well-established colitis model...
March 9, 2024: Brain, Behavior, and Immunity
https://read.qxmd.com/read/38465655/dietary-lipoic-acid-alleviates-autism-like-behavior-induced-by-acrylamide-in-adolescent-mice-the-potential-involvement-of-the-gut-brain-axis
#26
JOURNAL ARTICLE
Jin Ye, Hua Fan, Renjie Shi, Ge Song, Xiaoning Wu, Danna Wang, Bing Xia, Zhenting Zhao, Beita Zhao, Xuebo Liu, Yutang Wang, Xiaoshuang Dai
Consuming fried foods has been associated with an increased susceptibility to mental health disorders. Nevertheless, the impact of alpha-lipoic acid (α-LA, LA) on fried food-induced autism-like behavior remains unclear. This study aimed to explore how LA affects autism-related behavior and cognitive deficits caused by acrylamide in mice, a representative food hazard found in fried foods. This improvement was accomplished by enhanced synaptic plasticity, increased neurotrophin expression, elevated calcium-binding protein D28k, and restored serotonin...
March 11, 2024: Food & Function
https://read.qxmd.com/read/38465231/placebo-resistant-gut-bacteria-akkermansia-muciniphila-spp-and-familial-mediterranean-fever-disease
#27
JOURNAL ARTICLE
Elya Pepoyan, Francesco Marotta, Anahit Manvelyan, Artak Galstyan, Lena Stepanyan, Hasmik Grigoryan, Liana Grigoryan, Mikayel Mikayelyan, Marine Balayan, Natalya Harutyunyan, Susanna Mirzabekyan, Vardan Tsaturyan, Tamas Torok, Astghik Pepoyan
INTRODUCTION: Despite numerous investigations into the impact of drugs/probiotics on the gut microbiota composition in Familial Mediterranean Fever (FMF) patients, the question as to whether there exists a significant bacterial diversity(ies) independent of the placebo effect that can be reliably considered in clinical and nutritional trials remains unresolved. METHODS: This study represents the in augural analysis of the placebo's influence on the gut microbiota of both healthy individuals and FMF afflicted men, utilizing previously collected data from PhyloChip™ DNA microarray experiments...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38463411/a-possible-role-of-akkermansia-muciniphila-in-the-treatment-of-olanzapine-induced-weight-gain
#28
REVIEW
Francesca Bertossi
Second-generation antipsychotics are mainly used in both acute and long-term treatment of major psychiatric disorders. Although better tolerated than first-generation antipsychotic drugs, they can frequently induce weight gain and metabolic disorders, of these, olanzapine is one of the drugs more likely to induce these side effects. There is consistent evidence of the role of gut microbiota in modulating the gut-brain axis with complex crosstalk with the host involving satiety signaling pathways, food intake behavior, and weight and metabolic regulation...
March 2024: Curēus
https://read.qxmd.com/read/38462652/endoplasmic-reticulum-stress-a-possible-connection-between-intestinal-inflammation-and-neurodegenerative-disorders
#29
REVIEW
Giorgio Vivacqua, Romina Mancinelli, Stefano Leone, Rosa Vaccaro, Ludovica Garro, Simone Carotti, Ludovica Ceci, Paolo Onori, Luigi Pannarale, Antonio Franchitto, Eugenio Gaudio, Arianna Casini
BACKGROUND: Different studies have shown the key role of endoplasmic reticulum (ER) stress in autoimmune and chronic inflammatory disorders, as well as in neurodegenerative diseases. ER stress leads to the formation of misfolded proteins which affect the secretion of different cell types that are crucial for the intestinal homeostasis. PURPOSE: In this review, we discuss the role of ER stress and its involvement in the development of inflammatory bowel diseases, chronic conditions that can cause severe damage of the gastrointestinal tract, focusing on the alteration of Paneth cells and goblet cells (the principal secretory phenotypes of the intestinal epithelial cells)...
March 10, 2024: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://read.qxmd.com/read/38462572/review-of-research-progress-on-intestinal-microbiota-based-on-metabolism-and-inflammation-for-depression
#30
REVIEW
Yunxiang Tan, Mengyu Xu, Deng Lin
Depression is a prevalent mental illness, affecting a significant portion of the global population. Recent research has highlighted the crucial role of the gut microbiota in both metabolic and central nervous health. By reviewing literature from various databases, including Pubmed, Science Direct, Web of Science, and Scopus, spanning the years 2005-2023, a comprehensive search was conducted using keywords such as "Depression" and "Gut Microbiota". The gut microbiota acts as a "second brain" in humans and can communicate bidirectionally with the brain through the Brain-gut-microbiota axis pathway...
March 10, 2024: Archives of Microbiology
https://read.qxmd.com/read/38462196/the-effects-of-heavy-metal-exposure-on-brain-and-gut-microbiota-a-systematic-review-of-animal-studies
#31
REVIEW
Simona Porru, Ana Esplugues, Sabrina Llop, Juana María Delgado-Saborit
The gut-brain axis is a crucial interface between the central nervous system and the gut microbiota. Recent evidence shows that exposure to environmental contaminants, such as heavy metals, can cause dysbiosis in gut microbiota, which may affect the gut-brain communication, impacting aspects of brain function and behavior. This systematic review of the literature aims to evaluate whether deleterious effects on brain function due to heavy metal exposure could be mediated by changes in the gut microbiota profile...
March 8, 2024: Environmental Pollution
https://read.qxmd.com/read/38461954/ad-derived-bone-marrow-transplant-induces-proinflammatory-immune-peripheral-mechanisms-accompanied-by-decreased-neuroplasticity-and-reduced-gut-microbiome-diversity-affecting-ad-like-phenotype-in-the-absence-of-a%C3%AE-neuropathology
#32
JOURNAL ARTICLE
Ruth Iban-Arias, Eun-Jeong Yang, Elizabeth Griggs, Ariana Soares Dias Portela, Aya Osman, Kyle J Trageser, Mahadi Shahed, Giulio Maria Pasinetti
Immune system dysfunction is increasingly recognized as a significant feature that contributes to Alzheimer's disease (AD) pathogenesis, reflected by alterations in central and peripheral responses leading to detrimental mechanisms that can contribute to the worsening of the disease. The damaging alterations in the peripheral immune system may disrupt the peripheral-central immune crosstalk, implicating the gut microbiota in this complex interaction. The central hypothesis posits that the immune signature inherently harbored in bone marrow (BM) cells can be transferred through allogeneic transplantation, influencing the recipient's immune system and modulating peripheral, gut, and brain immune responses...
March 8, 2024: Brain, Behavior, and Immunity
https://read.qxmd.com/read/38461265/multi-omics-analysis-of-the-gut-microbiome-and-metabolites-associated-with-the-psychoneurological-symptom-cluster-in-children-with-cancer-receiving-chemotherapy
#33
JOURNAL ARTICLE
Jinbing Bai, Ronald Eldridge, Madelyn Houser, Melissa Martin, Christie Powell, Kathryn S Sutton, Hye In Noh, Yuhua Wu, Thomas Olson, Konstantinos T Konstantinidis, Deborah W Bruner
BACKGROUND: Children with cancer receiving chemotherapy commonly report a cluster of psychoneurological symptoms (PNS), including pain, fatigue, anxiety, depression, and cognitive dysfunction. The role of the gut microbiome and its functional metabolites in PNS is rarely studied among children with cancer. This study investigated the associations between the gut microbiome-metabolome pathways and PNS in children with cancer across chemotherapy as compared to healthy children. METHODS: A case-control study was conducted...
March 9, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38455088/methodological-recommendations-for-human-microbiota-gut-brain-axis-research
#34
REVIEW
Yangwenshan Ou, Clara Belzer, Hauke Smidt, Carolina de Weerth
Observational studies have determined numerous correlations between sequence-based gut microbiota data and human mental traits. However, these associations are often inconsistent across studies. This inconsistency is one of the reasons that mechanistic validation studies of the observed correlations are lagging, making it difficult to establish causal associations. The absence of consistent study findings may partially be due to the lack of clear guidelines for identifying confounders of relations between complex microbial communities and mental conditions...
2024: Microbiome Res Rep
https://read.qxmd.com/read/38455083/pathways-linking-microbiota-gut-brain-axis-with-neuroinflammatory-mechanisms-in-alzheimer-s-pathophysiology
#35
REVIEW
Nathaniel Hochuli, Saurabh Kadyan, Gwoncheol Park, Cole Patoine, Ravinder Nagpal
Disturbances in the local and peripheral immune systems are closely linked to a wide range of diseases. In the context of neurodegenerative disorders such as Alzheimer's disease (AD), inflammation plays a crucial role, often appearing as a common manifestation despite the variability in the occurrence of other pathophysiological hallmarks. Thus, combating neuroinflammation holds promise in treating complex pathophysiological diseases like AD. Growing evidence suggests the gut microbiome's crucial role in shaping the pathogenesis of AD by influencing inflammatory mediators...
2024: Microbiome Res Rep
https://read.qxmd.com/read/38455067/combined-repetitive-transcranial-magnetic-stimulation-and-gut-microbiota-modulation-through-the-gut-brain-axis-for-prevention-and-treatment-of-autism-spectrum-disorder
#36
REVIEW
Pengya Feng, Yangyang Zhang, Yonghong Zhao, Pengju Zhao, Enyao Li
Autism spectrum disorder (ASD) encompasses a range of neurodevelopmental conditions characterized by enduring impairments in social communication and interaction together with restricted repetitive behaviors, interests, and activities. No targeted pharmacological or physical interventions are currently available for ASD. However, emerging evidence has indicated a potential association between the development of ASD and dysregulation of the gut-brain axis. Repetitive transcranial magnetic stimulation (rTMS), a noninvasive diagnostic and therapeutic approach, has demonstrated positive outcomes in diverse psychiatric disorders; however, its efficacy in treating ASD and its accompanying gastrointestinal effects, particularly the effects on the gut-brain axis, remain unclear...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38454447/pathophysiology-of-acute-lung-injury-in-patients-with-acute-brain-injury-the-triple-hit-hypothesis
#37
REVIEW
Mairi Ziaka, Aristomenis Exadaktylos
It has been convincingly demonstrated in recent years that isolated acute brain injury (ABI) may cause severe dysfunction of peripheral extracranial organs and systems. Of all potential target organs and systems, the lung appears to be the most vulnerable to damage after ABI. The pathophysiology of the bidirectional brain-lung interactions is multifactorial and involves inflammatory cascades, immune suppression, and dysfunction of the autonomic system. Indeed, the systemic effects of inflammatory mediators in patients with ABI create a systemic inflammatory environment ("first hit") that makes extracranial organs vulnerable to secondary procedures that enhance inflammation, such as mechanical ventilation (MV), surgery, and infections ("second hit")...
March 7, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38451317/bile-acid-profile-associated-with-csf-and-pet-biomarkers-in-alzheimer-s-disease
#38
JOURNAL ARTICLE
Fardin Nabizadeh, Parya Valizadeh, Mohammad Sadegh Fallahi
BACKGROUND: Recent studies have shown that gut microbiota can affect the development of Alzheimer's disease (AD) through various mechanisms. Bile acids (BAs), which are the final byproducts of cholesterol metabolism created through both the human body and gut microbiome, appear to be influenced by gut microbiota and may impact AD pathological characteristics such as the accumulation of tau and amyloid-β. We aimed to investigate the associations between various serum BAs and CSF biomarkers (including Aβ, total tau, and p-tau)...
March 7, 2024: Aging Clinical and Experimental Research
https://read.qxmd.com/read/38450172/electroacupuncture-at-st25-corrected-gut-microbial-dysbiosis-and-snpc-lipid-peroxidation-in-parkinson-s-disease-rats
#39
JOURNAL ARTICLE
Xuan-Ming Hu, Li-Zhe-Xiong Song, Zhi-Zi Zhang, Xi Ruan, Hai-Chang Li, Zhi Yu, Lin Huang
INTRODUCTION: Parkinson's disease (PD) remains one kind of a complex, progressive neurodegenerative disease. Levodopa and dopamine agonists as widely utilized PD therapeutics have not shown significant positive long-term outcomes. Emerging evidences indicate that electroacupuncture (EA) have potential effects on the therapy of nervous system disorders, particularly PD, but its specific underlying mechanism(s) remains poorly understood, leading to the great challenge of clinical application and management...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38449863/protective-effects-of-fecal-microbiota-transplantation-against-ischemic-stroke-and-other-neurological-disorders-an-update
#40
REVIEW
Tousif Ahmed Hediyal, C Vichitra, Nikhilesh Anand, Mahendran Bhaskaran, Saeefh M Essa, Pravir Kumar, M Walid Qoronfleh, Mohammed Akbar, Ruchika Kaul-Ghanekar, Arehally M Mahalakshmi, Jian Yang, Byoung-Joon Song, Tanya M Monaghan, Meena Kishore Sakharkar, Saravana Babu Chidambaram
The bidirectional communication between the gut and brain or gut-brain axis is regulated by several gut microbes and microbial derived metabolites, such as short-chain fatty acids, trimethylamine N-oxide, and lipopolysaccharides. The Gut microbiota (GM) produce neuroactives, specifically neurotransmitters that modulates local and central neuronal brain functions. An imbalance between intestinal commensals and pathobionts leads to a disruption in the gut microbiota or dysbiosis, which affects intestinal barrier integrity and gut-immune and neuroimmune systems...
2024: Frontiers in Immunology
keyword
keyword
36932
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.