Tousif Ahmed Hediyal, C Vichitra, Nikhilesh Anand, Mahendran Bhaskaran, Saeefh M Essa, Pravir Kumar, M Walid Qoronfleh, Mohammed Akbar, Ruchika Kaul-Ghanekar, Arehally M Mahalakshmi, Jian Yang, Byoung-Joon Song, Tanya M Monaghan, Meena Kishore Sakharkar, Saravana Babu Chidambaram
The bidirectional communication between the gut and brain or gut-brain axis is regulated by several gut microbes and microbial derived metabolites, such as short-chain fatty acids, trimethylamine N-oxide, and lipopolysaccharides. The Gut microbiota (GM) produce neuroactives, specifically neurotransmitters that modulates local and central neuronal brain functions. An imbalance between intestinal commensals and pathobionts leads to a disruption in the gut microbiota or dysbiosis, which affects intestinal barrier integrity and gut-immune and neuroimmune systems...
2024: Frontiers in Immunology