Jeffrey Capadona, George Hoeferlin, Sarah Grabinski, Lindsey Druschel, Jonathan Duncan, Grace Burkhart, Gwendolyn Weagraff, Alice Lee, Christopher Hong, Meera Bambroo, Hannah Olivares, Tejas Bajwa, William Memberg, Jennifer Sweet, Hoda Amani Hamedani, Abhinav Acharya, Ana Hernandez-Reynoso, Curtis Donskey, George Jaskiw, Ricky Chan, A Ajiboye, Horst von Recum, Liangliang Zhang
Brain-machine interface performance is largely affected by the neuroinflammatory responses resulting in large part from blood-brain barrier (BBB) damage following intracortical microelectrode implantation. Recent findings strongly suggest that certain gut bacterial constituents penetrate the BBB and are resident in various brain regions of rodents and humans, both in health and disease. Therefore, we hypothesized that damage to the BBB caused by microelectrode implantation could amplify dysregulation of the microbiome-gut-brain axis...
March 7, 2024: Research Square