keyword
https://read.qxmd.com/read/38497979/probiotics-in-autism-spectrum-disorders-a-systematic-review-of-clinical-studies-and-future-directions
#1
JOURNAL ARTICLE
Olga Barba-Vila, Helena García-Mieres, Belén Ramos
CONTEXT: It is hypothesized that gut dysbiosis, a typical feature of patients with autism spectrum disorder (ASD), could be involved in the origin of this neurodevelopmental disorder. Therefore, the use of probiotics to restore gastrointestinal (GI) equilibrium might be a promising therapeutic strategy due to its capacity to balance the gut-brain axis and behavioral responses. OBJECTIVE: To summarize current knowledge on the use of probiotics to treat core clinical ASD symptoms and concomitant GI signs, compare the design of published studies with those of ongoing trials, assess the near future of this field, and provide recommendations for improving novel studies...
March 18, 2024: Nutrition Reviews
https://read.qxmd.com/read/38496527/bacteria-invade-the-brain-following-sterile-intracortical-microelectrode-implantation
#2
Jeffrey Capadona, George Hoeferlin, Sarah Grabinski, Lindsey Druschel, Jonathan Duncan, Grace Burkhart, Gwendolyn Weagraff, Alice Lee, Christopher Hong, Meera Bambroo, Hannah Olivares, Tejas Bajwa, William Memberg, Jennifer Sweet, Hoda Amani Hamedani, Abhinav Acharya, Ana Hernandez-Reynoso, Curtis Donskey, George Jaskiw, Ricky Chan, A Ajiboye, Horst von Recum, Liangliang Zhang
Brain-machine interface performance is largely affected by the neuroinflammatory responses resulting in large part from blood-brain barrier (BBB) damage following intracortical microelectrode implantation. Recent findings strongly suggest that certain gut bacterial constituents penetrate the BBB and are resident in various brain regions of rodents and humans, both in health and disease. Therefore, we hypothesized that damage to the BBB caused by microelectrode implantation could amplify dysregulation of the microbiome-gut-brain axis...
March 7, 2024: Research Square
https://read.qxmd.com/read/38495755/gut-microbiota-and-its-metabolites-in-alzheimer-s-disease-from-pathogenesis-to-treatment
#3
JOURNAL ARTICLE
Xinfu Zou, Guoqiang Zou, Xinyan Zou, Kangfeng Wang, Zetao Chen
INTRODUCTION: An increasing number of studies have demonstrated that altered microbial diversity and function (such as metabolites), or ecological disorders, regulate bowel-brain axis involvement in the pathophysiologic processes in Alzheimer's disease (AD). The dysregulation of microbes and their metabolites can be a double-edged sword in AD, presenting the possibility of microbiome-based treatment options. This review describes the link between ecological imbalances and AD, the interactions between AD treatment modalities and the microbiota, and the potential of interventions such as prebiotics, probiotics, synbiotics, fecal microbiota transplantation, and dietary interventions as complementary therapeutic strategies targeting AD pathogenesis and progression...
2024: PeerJ
https://read.qxmd.com/read/38495110/acupuncture-modulates-the-gut-microbiota-in-alzheimer-s-disease-current-evidence-challenges-and-future-opportunities
#4
REVIEW
Long Yan, Hong Li, Yulin Qian, Qidi Liu, Shan Cong, Baomin Dou, Yu Wang, Meng Wang, Tao Yu
Alzheimer's disease, one of the most severe and common neurodegenerative diseases, has no effective cure. Therefore it is crucial to explore novel and effective therapeutic targets. The gut microbiota - brain axis has been found to play a role in Alzheimer's disease by regulating the neuro-immune and endocrine systems. At the same time, acupuncture can modulate the gut microbiota and may impact the course of Alzheimer's disease. In this Review, we discuss recent studies on the role of acupuncture on the gut microbiota as well current challenges and future opportunities of acupuncture as potential treatment for the prevention and treatment of Alzheimer's disease...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38494933/paeoniflorin-alleviates-anxiety-and-visceral-hypersensitivity-via-hpa-axis-and-bdnf-trkb-plc%C3%AE-1-pathway-in-maternal-separation-induced-ibs-like-rats
#5
JOURNAL ARTICLE
Ruifeng Liang, Wenjing Ge, Xianmei Song, Huisen Wang, Weifeng Cui, Xuexia Zhang, Zheng Wei, Gengsheng Li
BACKGROUND: Irritable Bowel Syndrome (IBS) is a prevalent gastrointestinal disorder that significantly diminishes the quality of life for affected individuals. The pathophysiology of IBS remains poorly understood, and available therapeutic options for IBS are limited. The crucial roles of brain-gut interaction, which is mediated by the Hypothalamic-Pituitary-Adrenocortical (HPA) axis and the autonomic nervous system in IBS, have attracted increasing attention. OBJECTIVE: The objective of this study was to examine the impact of paeoniflorin (PF) on anxiety and visceral hypersensitivity in maternal separation-induced IBS-like rats...
March 15, 2024: Current Molecular Pharmacology
https://read.qxmd.com/read/38494840/research-progress-on-the-roles-of-dopamine-and-dopamine-receptors-in-digestive-system-diseases
#6
REVIEW
Xianmin Lu, Qi Liu, Ya Deng, Jiangbo Wu, Xingyi Mu, Xiaoxu Yang, Ting Zhang, Chen Luo, Zhuo Li, Siqi Tang, Yanxia Hu, Qian Du, Jingyu Xu, Rui Xie
Dopamine (DA) is a neurotransmitter synthesized in the human body that acts on multiple organs throughout the body, reaching them through the blood circulation. Neurotransmitters are special molecules that act as messengers by binding to receptors at chemical synapses between neurons. As ligands, they mainly bind to corresponding receptors on central or peripheral tissue cells. Signalling through chemical synapses is involved in regulating the activities of various body systems. Lack of DA or a decrease in DA levels in the brain can lead to serious diseases such as Parkinson's disease, schizophrenia, addiction and attention deficit disorder...
April 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38494056/protease-induced-excitation-of-dorsal-root-ganglion-neurons-in-response-to-acute-perturbation-of-the-gut-microbiota-is-associated-with-visceral-and-somatic-hypersensitivity
#7
JOURNAL ARTICLE
Corey C Baker, Jessica L Sessenwein, Hannah M Wood, Yang Yu, Quentin Tsang, Taylor A Alward, Nestor N Jimenez Vargas, Amal Abu Omar, Abby McDonnel, Julia Segal, Calvin P Sjaarda, Nigel W Bunnett, Brian L Schmidt, Alberto Caminero, Nadejda Boev, Courtney Bannerman, Nader Ghasemlou, Prameet M Sheth, Stephen J Vanner, David E Reed, Alan E Lomax
Abdominal pain is a major symptom of diseases that are associated with microbial dysbiosis, including irritable bowel syndrome and inflammatory bowel disease. Germ-free mice are more prone to abdominal pain than conventionally-housed mice, and reconstitution of the microbiota in germ-free mice reduces abdominal pain sensitivity. However, the mechanisms underlying microbial modulation of pain remain elusive. We hypothesized that disruption of the intestinal microbiota modulates the excitability of peripheral nociceptive neurons...
March 15, 2024: Cellular and Molecular Gastroenterology and Hepatology
https://read.qxmd.com/read/38493723/notoginsenoside-r1-alleviates-cerebral-ischemia-reperfusion-injury-by-inhibiting-the-tlr4-myd88-nf-%C3%AE%C2%BAb-signaling-pathway-through-microbiota-gut-brain-axis
#8
JOURNAL ARTICLE
Shuxia Zhang, Qiuyan Chen, Meiqi Jin, Jiahui Ren, Xiao Sun, Zhixiu Zhang, Yun Luo, Xiaobo Sun
BACKGROUND: Ischemic stroke (IS) ranks as the second common cause of death worldwide. However, a narrow thrombolysis timeframe and ischemia-reperfusion (I/R) injury limits patient recovery. Moreover, anticoagulation and antithrombotic drugs do not meet the clinical requirements. Studies have demonstrated close communication between the brain and gut microbiota in IS. Notoginsenoside R1 (NG-R1), a significant component of the total saponins from Panax notoginseng, has been demonstrated to be effective against cerebral I/R injury...
March 11, 2024: Phytomedicine
https://read.qxmd.com/read/38493312/crosstalk-between-covid-19-and-the-gut-brain-axis-a-gut-feeling
#9
JOURNAL ARTICLE
Nida Kalam, Vinod R M T Balasubramaniam
The microbes in the gut are crucial for maintaining the body's immune system and overall gut health. However, it is not fully understood how an unstable gut environment can lead to more severe cases of SARS-CoV-2 infection. The gut microbiota also plays a role in the gut-brain axis and interacts with the central nervous system through metabolic and neuroendocrine pathways. The interaction between the microbiota and the host's body involves hormonal, immune, and neural pathways, and any disruption in the balance of gut bacteria can lead to dysbiosis, which contributes to pathogen growth...
March 16, 2024: Postgraduate Medical Journal
https://read.qxmd.com/read/38490542/evaluation-of-the-protective-bioactivity-and-molecular-mechanism-verification-of-lactoferrin-in-an-alzheimer-s-mouse-model-with-ulcerative-enteritis
#10
JOURNAL ARTICLE
Longyi Ran, Jiarui Shi, Yinan Lin, Chenlin Xu, Zhengkun Han, Sen Tian, Xiaoyang Qin, Qinjin Li, Taiyu Zhang, Huiying Li, Yu Zhang
The development of new drug therapies for Alzheimer's disease (AD) is an important research topic today, but the pathogenesis of AD has not been thoroughly studied, and there are still several shortcomings in existing drug therapies. Therefore, this study aims to explore the molecular mechanism of lactoferrin in the treatments of AD and ulcerative colitis (UC) which are susceptible to AD, starting from the principle of "one drug, two diseases, and the same treatment." This study used pathological staining and specific indicators staining to preliminarily evaluate the interventions of lactoferrin on UC injury and AD progression...
March 13, 2024: Journal of Dairy Science
https://read.qxmd.com/read/38490517/novel-mechanisms-involved-in-leptin-sensitization-in-obesity
#11
REVIEW
Veronica Pena-Leon, Raquel Perez-Lois, Villalon Maria, Eva Prida, Diego Muñoz Moreno, Johan Fernø, Mar Quiñones, Omar Al-Massadi, Luisa M Seoane
Leptin is a hormone that is secreted by adipocytes in proportion to adipose tissue size, and that informs the brain about the energy status of the body. Leptin acts through its receptor LepRb, expressed mainly in the hypothalamus, and induces a negative energy balance by potent inhibition of feeding and activation of energy expenditure. These actions have led to huge expectations for the development of therapeutic targets for metabolic complications based on leptin-derived compounds. However, the majority of patients with obesity presents elevated leptin production, suggesting that in this setting leptin is ineffective in the regulation of energy balance...
March 13, 2024: Biochemical Pharmacology
https://read.qxmd.com/read/38490348/dietary-polyphenols-represent-a-phytotherapeutic-alternative-for-gut-dysbiosis-associated-neurodegeneration-a-systematic-review
#12
REVIEW
Amrita Chatterjee, Satish Kumar, Suparna Roy Sarkar, Ritabrata Halder, Rashmi Kumari, Sugato Banerjee, Biswatrish Sarkar
Globally, neurodegeneration and cerebrovascular disease are common and growing causes of morbidity and mortality. Pathophysiology of this group of diseases encompasses various factors from oxidative stress to gut microbial dysbiosis. The study of the etiology and mechanisms of oxidative stress as well as gut dysbiosis-induced neurodegeneration in Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, autism spectrum disorder, and Huntington's disease has recently received a lot of attention...
March 13, 2024: Journal of Nutritional Biochemistry
https://read.qxmd.com/read/38490298/alpha-glycosyl-isoquercitrin-alleviates-subchronic-social-defeat-stress-induced-depression-symptoms-by-modulating-the-microbiota-gut-brain-axis-in-mice
#13
JOURNAL ARTICLE
Hong Liu, Junjie Li, Shogo Takahashi, Atsushi Toyoda, Ryo Inoue, Mihoko Koyanagi, Shim-Mo Hayashi, Meiyu Xu, Yuki Yamamoto, Kentaro Nagaoka
AIMS: Increasing evidence suggests a link between gut microbial dysbiosis and the pathogenesis of depression. Alpha-glycosyl isoquercitrin (AGIQ), consisting of isoquercitrin and its glycosylated quercetin, has beneficial effects on the gut microbiome and brain function. Here, we detected the potential antidepressant impact of a four-week administration of AGIQ and its underlying mechanisms using a mouse model of depression. MAIN METHODS: Male C57BL/6 mice were orally administered AGIQ (0...
March 13, 2024: Life Sciences
https://read.qxmd.com/read/38488562/magnesium-l-threonate-treats-alzheimer-s-disease-by-modulating-the-microbiota-gut-brain-axis
#14
JOURNAL ARTICLE
Wang Liao, Jiana Wei, Chongxu Liu, Haoyu Luo, Yuting Ruan, Yingren Mai, Qun Yu, Zhiyu Cao, Jiaxin Xu, Dong Zheng, Zonghai Sheng, Xianju Zhou, Jun Liu
JOURNAL/nrgr/04.03/01300535-202410000-00029/figure1/v/2024-02-06T055622Z/r/image-tiff Disturbances in the microbiota-gut-brain axis may contribute to the development of Alzheimer's disease. Magnesium-L-threonate has recently been found to have protective effects on learning and memory in aged and Alzheimer's disease model mice. However, the effects of magnesium-L-threonate on the gut microbiota in Alzheimer's disease remain unknown. Previously, we reported that magnesium-L-threonate treatment improved cognition and reduced oxidative stress and inflammation in a double-transgenic line of Alzheimer's disease model mice expressing the amyloid-β precursor protein and mutant human presenilin 1 (APP/PS1)...
October 1, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38488556/unraveling-the-gut-brain-axis-the-impact-of-steroid-hormones-and-nutrition-on-parkinson-s-disease
#15
JOURNAL ARTICLE
Paula Maria Neufeld, Ralf A Nettersheim, Veronika Matschke, Matthias Vorgerd, Sarah Stahlke, Carsten Theiss
This comprehensive review explores the intricate relationship between nutrition, the gut microbiome, steroid hormones, and Parkinson's disease within the context of the gut-brain axis. The gut-brain axis plays a pivotal role in neurodegenerative diseases like Parkinson's disease, encompassing diverse components such as the gut microbiota, immune system, metabolism, and neural pathways. The gut microbiome, profoundly influenced by dietary factors, emerges as a key player. Nutrition during the first 1000 days of life shapes the gut microbiota composition, influencing immune responses and impacting both child development and adult health...
October 1, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38488543/going-straight-for-the-gut-gut-brain-axis-pathology-and-treatment-of-parkinson-s-disease
#16
JOURNAL ARTICLE
Dominique Ebedes, Cesar V Borlongan
No abstract text is available yet for this article.
October 1, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38488514/ginsenoside-rk3-regulates-tryptophan-metabolism-along-the-brain-gut-axis-by-targeting-tryptophan-hydroxylase-and-remodeling-the-intestinal-microenvironment-to-alleviate-depressive-like-behavior-in-mice
#17
JOURNAL ARTICLE
Jingjing Shao, Linlin Qu, Yao Liu, Jingjing Zhang, Yannan Liu, Jianjun Deng, Xiaoxuan Ma, Daidi Fan
Depression is a neuropsychiatric disease that significantly impacts the physical and mental health of >300 million people worldwide and places a major burden on society. Ginsenosides are the main active ingredient in ginseng and have been proven to have various pharmacological effects on the nervous system. Herein, we investigated the antidepressant effect of ginsenoside Rk3 and its underlying mechanism in a murine model of depression. Rk3 significantly improved depression-like behavior in mice, ameliorated the disturbance of the hypothalamus-pituitary-adrenal axis, and alleviated neuronal damage in the hippocampus and prefrontal cortex of mice...
March 15, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38488112/microbiome-and-its-impact-on-fetal-and-neonatal-brain-development-current-opinion-in-pediatrics
#18
JOURNAL ARTICLE
Nina M Frerichs, Tim G J de Meij, Hendrik J Niemarkt
PURPOSE OF REVIEW: Emerging evidence suggests that the gut microbiota and its metabolites regulate neurodevelopment and cognitive functioning via a bi-directional communication system known as the microbiota-gut-brain axis (MGBA). RECENT FINDINGS: The MGBA influences brain development and function via the hypothalamic-pituitary axis, the vagal nerve, immune signaling, bacterial production of neurotransmitters, and microbial metabolites like short-chain fatty acids, tryptophan derivatives, and bile acids...
March 11, 2024: Current Opinion in Clinical Nutrition and Metabolic Care
https://read.qxmd.com/read/38485093/identification-of-an-epilepsy-linked-gut-microbiota-signature-in-a-pediatric-rat-model-of-acquired-epilepsy
#19
JOURNAL ARTICLE
Antonella Riva, Eray Sahin, Greta Volpedo, Andrea Petretto, Chiara Lavarello, Rossella Di Sapia, Davide Barbarossa, Nasibeh Riahi Zaniani, Ilaria Craparotta, Maria Chiara Barbera, Uğur Sezerman, Annamaria Vezzani, Pasquale Striano, Teresa Ravizza
A dysfunctional gut microbiota-brain axis is emerging as a potential pathogenic mechanism in epilepsy, particularly in pediatric forms of epilepsy. To add new insights into gut-related changes in acquired epilepsy that develops early in life, we used a multi-omics approach in a rat model with a 56% incidence of epilepsy. The presence of spontaneous seizures was assessed in adult rats (n = 46) 5 months after status epilepticus induced by intra-amygdala kainate at postnatal day 13, by 2 weeks (24/7) ECoG monitoring...
March 12, 2024: Neurobiology of Disease
https://read.qxmd.com/read/38484610/oxidized-unmodified-polyethylene-microplastics-neurotoxicity-in-mice-perspective-from-microbiota-gut-brain-axis
#20
JOURNAL ARTICLE
Ji Wang, Ying Yang, Yongpeng Shi, Li Wei, Lan Gao, Mingxin Liu
Microplastics (MPs) are inevitably oxidized in the environment, and their potential toxicity to organisms has attracted wide attention. However, the neurotoxicity and mechanism of oxidized polyethylene (Ox-PE) MPs to organisms remain unclear. Herein, we prepared oxidized low-density polyethylene (Ox-LDPE) and established a model of MPs exposure by continuously orally gavage of C57BL/6 J mice with LDPE-MPs/Ox-LDPE-MPs for 28 days with or without oral administration of Lactobacillus plantarum DP189 and galactooligosaccharides (DP189&GOS)...
March 7, 2024: Environment International
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