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Invadopodia

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https://www.readbyqxmd.com/read/28098764/iqgap1-in-podosomes-invadosomes-is-involved-in-the-progression-of-glioblastoma-multiforme-depending-on-the-tumor-status
#1
Deborah Rotoli, Natalia Dolores Pérez-Rodríguez, Manuel Morales, María Del Carmen Maeso, Julio Ávila, Ali Mobasheri, Pablo Martín-Vasallo
Glioblastoma multiforme (GBM) is the most frequent and aggressive primary brain tumor. GBM is formed by a very heterogeneous astrocyte population, neurons, neovascularization and infiltrating myeloid cells (microglia and monocyte derived macrophages). The IQGAP1 scaffold protein interacts with components of the cytoskeleton, cell adhesion molecules, and several signaling molecules to regulate cell morphology and motility, cell cycle and other cellular functions. IQGAP1 overexpression and delocalization has been observed in several tumors, suggesting a role for this protein in cell proliferation, transformation and invasion...
January 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28094049/ep4-receptor-promotes-invadopodia-and-invasion-in-human-breast-cancer
#2
Felix Tönisen, Louisiane Perrin, Battuya Bayarmagnai, Koen van den Dries, Alessandra Cambi, Bojana Gligorijevic
The production of Prostaglandin E2 (PGE2) is elevated in human breast cancer cells. The abnormal expression of COX-2, which is involved in the synthesis of PGE2, was recently reported as a critical determinant for invasiveness of human breast cancer cells. Autocrine and paracrine PGE2-mediated stimulation of the PGE2 receptor EP4 transduces multiple signaling pathways leading to diverse patho-physiological effects, including tumor cell invasion and metastasis. It is known that PGE2-induced EP4 activation can transactivate the intracellular signaling pathway of the epidermal growth factor receptor (EGFR)...
January 10, 2017: European Journal of Cell Biology
https://www.readbyqxmd.com/read/28076931/varying-effects-of-egf-hgf-and-tgf%C3%AE-on-formation-of-invadopodia-and-invasiveness-of-melanoma-cell-lines-of-different-origin
#3
A Makowiecka, A Simiczyjew, D Nowak, A J Mazur
The understanding of melanoma malignancy mechanisms is essential for patient survival, because melanoma is responsible for ca. 75% of deaths related to skin cancers. Enhanced formation of invadopodia and extracellular matrix (ECM) degradation are two important drivers of cell invasion, and actin dynamics facilitate protrusive activity by providing a driving force to push through the ECM. We focused on the influence of epidermal growth factor (EGF), hepatocyte growth factor (HGF) and transforming growth factor β (TGFβ) on melanoma cell invasiveness, since they are observed in the melanoma microenvironment...
December 9, 2016: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/28061878/blockage-of-glycolysis-by-targeting-pfkfb3-suppresses-tumor-growth-and-metastasis-in-head-and-neck-squamous-cell-carcinoma
#4
Hui-Min Li, Jie-Gang Yang, Zhuo-Jue Liu, Wei-Ming Wang, Zi-Li Yu, Jian-Gang Ren, Gang Chen, Wei Zhang, Jun Jia
BACKGROUND: Many cancers including head and neck squamous cell carcinoma (HNSCC) are characterized by a metabolic rewiring with increased glucose uptake and lactate production, termed as aerobic glycolysis. Targeting aerobic glycolysis presents a promising strategy for cancer therapy. This study investigates the therapeutic potential of glycolysis blockage by targeting phosphofructokinase-2/fructose-2, 6-bisphosphatase 3 (PFKFB3) in HNSCC. METHODS: 1-(4-pyridinyl)-3-(2-quinolinyl)-2-propen-1-one (PFK15) was used as a selective antagonist of PFKFB3...
January 7, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/28012439/oxidative-stress-in-cancer-and-fibrosis-opportunity-for-therapeutic-intervention-with-antioxidant-compounds-enzymes-and-nanoparticles
#5
REVIEW
Jingga Morry, Worapol Ngamcherdtrakul, Wassana Yantasee
Oxidative stress, mainly contributed by reactive oxygen species (ROS), has been implicated in pathogenesis of several diseases. We review two primary examples; fibrosis and cancer. In fibrosis, ROS promote activation and proliferation of fibroblasts and myofibroblasts, activating TGF-β pathway in an autocrine manner. In cancer, ROS account for its genomic instability, resistance to apoptosis, proliferation, and angiogenesis. Importantly, ROS trigger cancer cell invasion through invadopodia formation as well as extravasation into a distant metastasis site...
December 16, 2016: Redox Biology
https://www.readbyqxmd.com/read/27981735/research-highlights
#6
EDITORIAL
(no author information available yet)
In this issue, we highlight work from Prekeris and colleagues reporting a role for Rab40b in formation of invadopodia in breast cancer cells, a study by Simarro and colleagues that shows how FASTKD3 modulates mitochondrial mRNA stability and promotes translation, and a report by Pin and colleagues that demonstrates how cell proliferation drives cell migration along the intestinal epithelial villi.
December 2016: FEBS Journal
https://www.readbyqxmd.com/read/27921151/free-boundary-problem-for-cell-protrusion-formations-theoretical-and-numerical-aspects
#7
Olivier Gallinato, Masahito Ohta, Clair Poignard, Takashi Suzuki
In this paper, a free boundary problem for cell protrusion formation is studied theoretically and numerically. The cell membrane is precisely described thanks to a level set function, whose motion is due to specific signalling pathways. The aim is to model the chemical interactions between the cell and its environment, in the process of invadopodia or pseudopodia formation. The model consists of Laplace equation with Dirichlet condition inside the cell coupled to Laplace equation with Neumann condition in the outer domain...
December 5, 2016: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/27912101/the-cytoskeleton-architecture-of-algivorous-protoplast-feeders-viridiraptoridae-rhizaria-indicates-actin-guided-perforation-of-prey-cell-walls
#8
Anna Busch, Sebastian Hess
Several distantly related, phagotrophic microeukaryotes share the remarkable ability to perforate foreign cell walls in a well-defined pattern to acquire protoplast material as food. The underlying cellular processes, especially the local application of cell wall degrading agents, are still unexplored. We examined the distribution of F-actin and alpha-tubulin in the algivorous, viridiraptorid amoeboflagellates Orciraptor agilis and Viridiraptor invadens over their life histories using phalloidin conjugates and immunolocalization...
October 31, 2016: Protist
https://www.readbyqxmd.com/read/27909076/rab40b-and-tks5-interact-at-invadopodia-during-metastasis
#9
(no author information available yet)
No abstract text is available yet for this article.
December 1, 2016: Journal of Cell Science
https://www.readbyqxmd.com/read/27901093/macrophage-dependent-tumor-cell-transendothelial-migration-is-mediated-by-notch1-mena-inv-initiated-invadopodium-formation
#10
Jeanine Pignatelli, Jose Javier Bravo-Cordero, Minna Roh-Johnson, Saumil J Gandhi, Yarong Wang, Xiaoming Chen, Robert J Eddy, Alice Xue, Robert H Singer, Louis Hodgson, Maja H Oktay, John S Condeelis
The process of intravasation involving transendothelial migration is a key step in metastatic spread. How the triple cell complex composed of a macrophage, Mena over-expressing tumor cell and endothelial cell, called the tumor microenvironment of metastasis (TMEM), facilitates tumor cell transendothelial migration is not completely understood. Previous work has shown that the physical contact between a macrophage and tumor cell results in the formation of invadopodia, actin-rich matrix degrading protrusions, important for tumor cell invasion and transendothelial migration and tumor cell dissemination...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27888616/ccl2-egf-positive-feedback-loop-between-cancer-cells-and-macrophages-promotes-cell-migration-and-invasion-in-head-and-neck-squamous-cell-carcinoma
#11
Lu Gao, Feng-Qin Wang, Hui-Min Li, Jie-Gang Yang, Jian-Gang Ren, Ke-Fei He, Bing Liu, Wei Zhang, Yi-Fang Zhao
Head and neck squamous cell carcinoma (HNSCC) represents the most frequent malignancy in the head and neck region, and the survival rate has not been improved significantly over the past three decades. It has been reported the infiltrated macrophages contribute to the malignant progression of HNSCC. However, the crosstalk between macrophages and cancer cells remains poorly understood. In the present study, we explored interactions between monocytes/macrophages and HNSCC cells by establishing the direct co-culture system, and found that the crosstalk promoted the migration and invasion of cancer cells by enhancing the invadopodia formation through a CCL2/EGF positive feedback loop...
November 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27845909/platelet-derived-growth-factor-receptor-alpha-mediates-nodal-metastases-in-papillary-thyroid-cancer-by-driving-the-epithelial-mesenchymal-transition
#12
Esther Ekpe-Adewuyi, Ana Lopez-Campistrous, Xiaoyun Tang, David N Brindley, Todd P W McMullen
Recently platelet derived growth factor receptor-alpha (PDGFRα) was recognized as a potential target to treat aggressive papillary thyroid cancer given its strong association with lymph node metastases. However, it is unclear how PDGFRα potentiates metastases and if it works through the canonical MAPK pathway traditionally linked to PTC oncogenesis. We explored the phenotypic changes driven by PDGFRα activation in human papillary thyroid cancer (PTC) cells and the downstream signalling cascades through which they are effected...
November 11, 2016: Oncotarget
https://www.readbyqxmd.com/read/27824079/mena-inv-dysregulates-cortactin-phosphorylation-to-promote-invadopodium-maturation
#13
Maxwell D Weidmann, Chinmay R Surve, Robert J Eddy, Xiaoming Chen, Frank B Gertler, Ved P Sharma, John S Condeelis
Invadopodia, actin-based protrusions of invasive carcinoma cells that focally activate extracellular matrix-degrading proteases, are essential for the migration and intravasation of tumor cells during dissemination from the primary tumor. We have previously shown that cortactin phosphorylation at tyrosine residues, in particular tyrosine 421, promotes actin polymerization at newly-forming invadopodia, promoting their maturation to matrix-degrading structures. However, the mechanism by which cells regulate the cortactin tyrosine phosphorylation-dephosphorylation cycle at invadopodia is unknown...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27802184/the-role-of-tks-adaptor-proteins-in-invadopodia-formation-growth-and-metastasis-of-melanoma
#14
Shinji Iizuka, Christopher Abdullah, Matthew D Buschman, Begoña Diaz, Sara A Courtneidge
Metastatic cancer cells are characterized by their ability to degrade and invade through extracellular matrix. We previously showed that the Tks adaptor proteins, Tks4 and Tks5, are required for invadopodia formation and/or function in Src-transformed fibroblasts and a number of human cancer cell types. In this study, we investigated the role of Tks adaptor proteins in melanoma cell invasion and metastasis. Knockdown of either Tks4 or Tks5 in both mouse and human melanoma cell lines resulted in a decreased ability to form invadopodia and degrade extracellular matrix...
October 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/27798239/phosphatidylinositol-4-kinase-ii%C3%AE-negatively-regulates-invadopodia-formation-and-suppresses-an-invasive-cellular-phenotype
#15
Ganiyu Olabanji Alli-Balogun, Christina A Gewinner, Ruth Jacobs, Janos Kriston-Vizi, Mark G Waugh, Shane Minogue
The type II phosphatidylinositol 4-kinase (PI4KII) enzymes synthesize the lipid phosphatidylinositol 4-phosphate (PI(4)P), which has been detected at the Golgi complex and endosomal compartments and recruits clathrin adaptors. Despite common mechanistic similarities between the isoforms, the extent of their redundancy is unclear. We found that depletion of PI4KIIα and PI4KIIβ using small interfering RNA led to actin remodeling. Depletion of PI4KIIβ also induced the formation of invadopodia containing membrane type I matrix metalloproteinase (MT1-MMP)...
December 15, 2016: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/27789576/the-role-and-regulation-of-rab40b-tks5-complex-during-invadopodia-formation-and-cancer-cell-invasion
#16
Abitha Jacob, Erik Linklater, Brian A Bayless, Traci Lyons, Rytis Prekeris
Invadopodia formation and extracellular matrix degradation are key events during cancer cell invasion, yet little is known about mechanisms mediating these processes. Here, we report that Rab40b plays a key role in mediating invadopodia function during breast cancer cell invasion. We also identify Tks5 (also known as SH3PXD2A), a known Src kinase substrate, as a new Rab40b effector protein and show that Tks5 functions as a tether that mediates Rab40b-dependent targeting of transport vesicles containing MMP2 and MMP9 to the extending invadopodia...
December 1, 2016: Journal of Cell Science
https://www.readbyqxmd.com/read/27780861/p70s6k1-s6k1-mediated-phosphorylation-regulates-phosphatidylinositol-4-phosphate-5-kinase-type-i-%C3%AE-degradation-and-cell-invasion
#17
Naser Jafari, Qiaodan Zheng, Liqing Li, Wei Li, Lei Qi, Jianyong Xiao, Tianyan Gao, Cai Huang
Phosphatidylinositol 4-phosphate 5-kinase type I γ (PIPKIγ90) ubiquitination and subsequent degradation regulate focal adhesion assembly, cell migration, and invasion. However, it is unknown how upstream signals control PIPKIγ90 ubiquitination or degradation. Here we show that p70S6K1 (S6K1), a downstream target of mechanistic target of rapamycin (mTOR), phosphorylates PIPKIγ90 at Thr-553 and Ser-555 and that S6K1-mediated PIPKIγ90 phosphorylation is essential for cell migration and invasion. Moreover, PIPKIγ90 phosphorylation is required for the development of focal adhesions and invadopodia, key machineries for cell migration and invasion...
December 2, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27776431/safflower-yellow-prevents-pulmonary-metastasis-of-breast-cancer-by-inhibiting-tumor-cell-invadopodia
#18
Huiying Fu, Renjie Wu, Yuanyuan Li, Lizong Zhang, Xiaofang Tang, Jue Tu, Weimin Zhou, Jianchao Wang, Qiyang Shou
Carthamus tinctorius L. is a traditional Chinese medicine that activates blood circulation and dissipates blood stasis, and has been extensively used as antitumor treatment in a clinical setting in single or in compound preparation form. However, empirical evidence and a better understanding of the possible mechanisms involved are still required. Here, we investigated the role of safflower yellow (SY), the active ingredient of C. tinctorius, in the pulmonary metastasis of breast cancer, and the underlying mechanism of action...
2016: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/27771248/dynamin2-gtpase-contributes-to-invadopodia-formation-in-invasive-bladder-cancer-cells
#19
Yubai Zhang, Maya Nolan, Hiroshi Yamada, Masami Watanabe, Yasutomo Nasu, Kohji Takei, Tetsuya Takeda
Cancer cell invasion is mediated by actin-based membrane protrusions termed invadopodia. Invadopodia consist of "core" F-actin bundles associated with adhesive and proteolytic machineries promoting cell invasion by degrading extracellular matrix (ECM). Formation of the F-actin core in invadopodia is regulated by various actin-binding proteins including Arp2/3 complex and cortactin. Dynamin GTPase localizes to the invadopodia and is implicated in cancer cell invasion, but its precise role at the invadopodia remained elusive...
October 19, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27770278/comprehensive-proteome-profiling-of-glioblastoma-derived-extracellular-vesicles-identifies-markers-for-more-aggressive-disease
#20
Duthika M Mallawaaratchy, Susannah Hallal, Ben Russell, Linda Ly, Saeideh Ebrahimkhani, Heng Wei, Richard I Christopherson, Michael E Buckland, Kimberley L Kaufman
Extracellular vesicles (EVs) play key roles in glioblastoma (GBM) biology and represent novel sources of biomarkers that are detectable in the peripheral circulation. Despite this notionally non-invasive approach to assess GBM tumours in situ, a comprehensive GBM EV protein signature has not been described. Here, EVs secreted by six GBM cell lines were isolated and analysed by quantitative high-resolution mass spectrometry. Overall, 844 proteins were identified in the GBM EV proteome, of which 145 proteins were common to EVs secreted by all cell lines examined; included in the curated EV compendium (Vesiclepedia_559; http://microvesicles...
October 21, 2016: Journal of Neuro-oncology
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