keyword
https://read.qxmd.com/read/38112552/case-324
#1
JOURNAL ARTICLE
Pokhraj Prakashchandra Suthar, Kathryn Hughes, Mustafa Mafraji, Melih Akyuz, Miral Jhaveri, Sumeet G Dua
A 69-year-old right-handed man with a history of substance use disorder, hypertension, and diabetes presented to the emergency department in an unresponsive state. Upon examination, apart from tachycardia (heart rate, 108 beats per minute), vital signs were within normal ranges (blood pressure, 134/102 mm Hg; temperature, 97.9°F [36.6°C]; respiratory rate, 16 breaths per minute; oxygen saturation, 96%). He had a Glasgow coma scale score of 8. Otherwise, the physical examination revealed no abnormalities...
December 2023: Radiology
https://read.qxmd.com/read/37701915/tenofovir-alafenamide-significantly-increased-serum-lipid-levels-compared-with-entecavir-therapy-in-chronic-hepatitis-b-virus-patients
#2
JOURNAL ARTICLE
Rui-Min Lai, Shan Lin, Miao-Miao Wang, Na Li, Jia-Hui Zhou, Xiao-Yu Lin, Tian-Bin Chen, Yue-Yong Zhu, Qi Zheng
BACKGROUND: Tenofovir alafenamide (TAF) has a serum lipid-raising effect in patients with HIV; however, its effect on serum lipids and nonalcoholic fatty liver disease (NAFLD) risk in patients with chronic hepatitis B ( CHB) is unclear. AIM: To compare the effects of TAF and entecavir (ETV) on serum lipid levels in patients with CHB. METHODS: In this retrospective cohort study, the data including the clinical features, serum lipids, and metabolic factors of patients with CHB at baseline and approximately 1 year after TAF or ETV treatment were collected and analyzed...
August 27, 2023: World Journal of Hepatology
https://read.qxmd.com/read/36302940/effectiveness-and-safety-of-statins-on-outcomes-in-patients-with-hiv-infection-a-systematic-review-and-meta-analysis
#3
JOURNAL ARTICLE
Njeodo Njongang Vigny, Kwadwo Osei Bonsu, Amudha Kadirvelu
Statins are hypolipidaemic in human immunodeficiency virus (HIV) positive individuals. However, their effect on all-cause mortality and rate of discontinuation is unclear. We conducted a systematic review to evaluate the impact of statins on all-cause mortality, discontinuation rates, and risk of adverse effects among HIV patients on highly active antiretroviral therapy (HAART). We searched four electronic databases from inception until October 2021 for trials and cohort studies evaluating the effects of statin treatment versus placebo in HIV patients...
October 27, 2022: Scientific Reports
https://read.qxmd.com/read/35546656/a-suspected-case-of-hyponatraemia-induced-rhabdomyolysis-a-case-report
#4
JOURNAL ARTICLE
Edward Reakes, Douglas Drak, David Gracey
BACKGROUND: Hyponatraemia is a documented but under-recognised cause of rhabdomyolysis, with the contrasting treatment strategies for the two conditions posing a unique challenge. Balancing the need for aggressive fluid replacement for the treatment of rhabdomyolysis, with the risk of rapidly correcting hyponatraemia is imperative. CASE PRESENTATION: A 52-year-old gentleman with a background of HIV infection and hypertension presented with seizures following methamphetamine use, acute water intoxication, and thiazide use...
May 11, 2022: BMC Nephrology
https://read.qxmd.com/read/32389183/short-course-direct-acting-antivirals-and-ezetimibe-to-prevent-hcv-infection-in-recipients-of-organs-from-hcv-infected-donors-a-phase-3-single-centre-open-label-study
#5
JOURNAL ARTICLE
Jordan J Feld, Marcelo Cypel, Deepali Kumar, Harel Dahari, Rafaela Vanin Pinto Ribeiro, Nikki Marks, Nellie Kamkar, Ilona Bahinskaya, Fernanda Q Onofrio, Mohamed A Zahoor, Orlando Cerrochi, Kathryn Tinckam, S Joseph Kim, Jeffrey Schiff, Trevor W Reichman, Michael McDonald, Carolina Alba, Thomas K Waddell, Gonzalo Sapisochin, Markus Selzner, Shaf Keshavjee, Harry L A Janssen, Bettina E Hansen, Lianne G Singer, Atul Humar
BACKGROUND: An increasing percentage of potential organ donors are infected with hepatitis C virus (HCV). After transplantation from an infected donor, establishment of HCV infection in uninfected recipients is near-universal, with the requirement for post-transplant antiviral treatment. The aim of this study was to determine if antiviral drugs combined with an HCV entry blocker given before and for 7 days after transplant would be safe and reduce the likelihood of HCV infection in recipients of organs from HCV-infected donors...
July 2020: Lancet. Gastroenterology & Hepatology
https://read.qxmd.com/read/31261583/risk-of-elevation-of-serum-creatine-kinase-among-hiv-positive-individuals-receiving-dolutegravir-based-combination-antiretroviral-therapy
#6
COMPARATIVE STUDY
Guan-Jhou Chen, Hsin-Yun Sun, Aristine Cheng, Yu-Chung Chuang, Yu-Shan Huang, Kuan-Yin Lin, Yi-Chia Huang, Wen-Chun Liu, Pei-Ying Wu, Chien-Ching Hung, Shan-Chwen Chang
We aimed to compare the risks of creatine kinase (CK) elevation between patients receiving dolutegravir-based antiretroviral therapy (ART) and those receiving non-integrase strand transfer inhibitor (InSTI)-based ART.HIV-positive patients seeking HIV outpatient care between February 2017 and March 2018 were retrospectively reviewed to collect information on ART, practices of vigorous exercise, and laboratory tests including CK level, plasma HIV RNA load, and concurrent medications. The incidences of CK elevation were estimated among patients receiving dolutegravir-based ART and those receiving non-InSTI-based ART...
June 2019: Medicine (Baltimore)
https://read.qxmd.com/read/31027057/case-report-of-triumeq-abacavir-dolutegravir-lamivudine-associated-rhabdomyolysis-in-a-human-immunodeficiency-virus-hiv-infected-patient
#7
JOURNAL ARTICLE
Muhammad Saad, Fernando Casado-Castillo, Paul Kelly
RATIONALE: With the existence of the human immunodeficiency virus (HIV) infection as a chronic disease, more often adverse effects of its treatment with the various antiretroviral therapies (ARTs) available have been recognized. Going further, Triumeq has been associated with a myriad of adverse effects, of which rhabdomyolysis is rarely reported in the literature. PATIENT CONCERNS: The patient presented with muscle tenderness over the lower limbs and dark brown-to-red colored urine...
April 2019: Medicine (Baltimore)
https://read.qxmd.com/read/29426734/inclusion-body-myositis-and-human-immunodeficiency-virus-type-1-a-new-case-report-and-literature-review
#8
REVIEW
Priscille Couture, Edoardo Malfatti, Geneviève Morau, Alexis Mathian, Fleur Cohen-Aubart, Hubert Nielly, Zahir Amoura, Patrick Cherin
Prevalence of muscle disease in human immunodeficiency virus (HIV) infection is less than 1% of patients with acquired immune deficiency syndrome. Sporadic inclusion body myositis (IBM) is observed in a few cases of patients infected by retroviruses such as HIV-1. A Caucasian man was diagnosed with HIV when he was 30 years old. The viral load was undetectable and CD4 cell count was 600/mm3 when the diagnosis of inclusion body myositis was confirmed. Histological findings were typical of IBM. The treatment consisted of immunoglobulin therapy for three years without effect...
April 2018: Neuromuscular Disorders: NMD
https://read.qxmd.com/read/28716131/rhabdomyolysis-in-an-hiv-cohort-epidemiology-causes-and-outcomes
#9
JOURNAL ARTICLE
Sahar H Koubar, Michelle M Estrella, Rugmini Warrier, Richard D Moore, Gregory M Lucas, Mohamed G Atta, Derek M Fine
BACKGROUND: The Literature on rhabdomyolysis in the HIV-positive population is sparse and limited. We aimed to explore the incidence, patient characteristics, etiologies and outcomes of rhabdomyolysis in a cohort of HIV-positive patients identified through the Johns Hopkins HIV clinical registry between June 1992 and April 2014. METHODS: A retrospective analysis of 362 HIV-positive patients with non-cardiac CK elevation ≥1000 IU/L was performed. Both inpatients and outpatients were included...
July 17, 2017: BMC Nephrology
https://read.qxmd.com/read/28060020/significant-association-between-statin-associated-myalgia-and-vitamin-d-deficiency-among-treated-hiv-infected-patients
#10
JOURNAL ARTICLE
Leonardo Calza, Eleonora Magistrelli, Vincenzo Colangeli, Marco Borderi, Ilaria Contadini, Isabella Bon, Maria Carla Re, Pierluigi Viale
BACKGROUND: Several studies have shown a significant association between vitamin D deficiency and an increased risk of statin-related symptomatic myalgia in the general population, but there are no data among HIV-infected persons. METHODS: A retrospective, cohort study was conducted to assess the incidence of symptomatic myalgia and elevation in serum creatine kinase level among HIV-positive adults on combination antiretroviral therapy and treated with atorvastatin or rosuvastatin for at least 12 months between 2011 and 2015 in our outpatient unit...
March 13, 2017: AIDS
https://read.qxmd.com/read/26515574/immune-mediated-necrotizing-myopathy-update-on-diagnosis-and-management
#11
REVIEW
Pari Basharat, Lisa Christopher-Stine
The idiopathic inflammatory myopathies (IIMs) comprise a group of autoimmune disorders that target skeletal muscle. They are characterized by typical laboratory and clinical features including muscle weakness, elevated muscle enzymes, characteristic histopathology of muscle biopsies, as well as electromyography abnormalities. The IIMs are divided into polymyositis, dermatomyositis, inclusion body myositis, nonspecific myositis, and immune-mediated necrotizing myopathy (IMNM). IMNM is distinguished by the absence of primary inflammation on muscle biopsy...
December 2015: Current Rheumatology Reports
https://read.qxmd.com/read/26069150/tenofovir-based-antiretroviral-therapy-in-%C3%A2-hbv-hiv-coinfection-results-from-the-treat-asia-hiv-observational-database
#12
MULTICENTER STUDY
David C Boettiger, Stephen Kerr, Rossana Ditangco, Romanee Chaiwarith, Patrick Ck Li, Tuti Parwati Merati, Thuy Thi Thanh Pham, Sasisopin Kiertiburanakul, Nagalingeswaran Kumarasamy, Saphonn Vonthanak, Christopher Kc Lee, Nguyen Van Kinh, Sanjay Pujari, Wing Wai Wong, Adeeba Kamarulzaman, Fujie Zhang, Evy Yunihastuti, Jun Yong Choi, Shinichi Oka, Oon Tek Ng, Pacharee Kantipong, Mahiran Mustafa, Winai Ratanasuwan, Nicolas Durier, Matthew Law
BACKGROUND: The World Health Organization recommends HBV-HIV-coinfected individuals start antiretroviral therapy containing tenofovir. Here we describe first-line tenofovir use and treatment outcomes in coinfected patients in Asia. METHODS: HBV surface antigen positive patients enrolled in the TREAT Asia HIV Observational Database who started first-line antiretroviral therapy were included. Logistic regression adjusted for period of treatment initiation was used to determine factors associated with tenofovir use...
2016: Antiviral Therapy
https://read.qxmd.com/read/25743017/corticoid-therapy-for-overlapping-syndromes-in-an-hiv-positive-patient
#13
JOURNAL ARTICLE
Yu Kaku, Shoko Kodama, Makiko Higuchi, Akihiro Nakamura, Masataka Nakamura, Tomoe Kaieda, Soichiro Takahama, Rumi Minami, Tomoya Miyamura, Eiichi Suematsu, Masahiro Yamamoto
Human immunodeficiency virus (HIV) infection disturbs the host's immune function and often coexists with various autoimmune and/or systemic rheumatic diseases with manifestations that sometimes overlap with each other. We herein present the case of a 43-year-old Japanese man infected with HIV who exhibited elevated serum creatine kinase and transaminases levels without any symptoms. He was diagnosed with autoimmune hepatitis, polymyositis and Sjögren's syndrome and received combined antiretroviral therapy (cART); however, the laboratory abnormalities persisted...
2015: Internal Medicine
https://read.qxmd.com/read/25369244/skeletal-muscle-toxicity-in-hiv-1-infected-patients-treated-with-a-raltegravir-containing-antiretroviral-therapy-a-cohort-study
#14
JOURNAL ARTICLE
Leonardo Calza, Ilaria Danese, Vincenzo Colangeli, Giacomo Vandi, Roberto Manfredi, Nicolò Girometti, Marco Borderi, Lucia Appolloni, Cristina Puggioli, Pierluigi Viale
To evaluate the frequency of myopathy and serum creatine kinase (CK) elevation associated with the use of the integrase inhibitor raltegravir we conducted a retrospective, cohort analysis assessing the incidence of skeletal muscle toxicity among HIV-infected patients treated with raltegravir. Adult HIV-infected patients who started a raltegravir-containing therapy were enrolled into the study. The skeletal muscle toxicity was defined by the presence of one or more of the following parameters: (1) isolated and significant CK elevation without signs or symptoms; (2) diffuse myalgia without weakness; (3) proximal muscle weakness; (4) rhabdomyolysis...
December 2014: AIDS Research and Human Retroviruses
https://read.qxmd.com/read/25230065/coexistence-of-congenital-syphilis-and-cytomegalovirus-infection-a-case-report
#15
LETTER
Noemi Mihalik, Eszter Bodrogi, Csaba Nádor, Eszter Ostorházi, Sarolta Kárpáti, Márta Marschalkó
No abstract text is available yet for this article.
2014: Acta Dermatovenerologica Croatica: ADC
https://read.qxmd.com/read/24737882/extreme-elevation-of-ferritin-and-creatine-kinase-in-primary-infection-with-hiv-1
#16
JOURNAL ARTICLE
Zahir Osman Eltahir Babiker, Tom Wingfield, James Galloway, Neil Snowden, Andrew Ustianowski
The diagnosis of primary HIV-1 infection can be challenging, especially in the absence of reported risks or when presenting features are unusual and uncommon. We report an atypical case of primary HIV-1 infection with HIV-1 subtype C in a 61-year old Caucasian man who presented with extreme hyperferritinaemia without iron overload and marked elevation of serum creatine kinase without rhabdomyolysis. In view of his symptomatic seroconversion and low baseline CD4+ T-lymphocyte count, the patient was treated promptly with combination antiretroviral therapy...
January 2015: International Journal of STD & AIDS
https://read.qxmd.com/read/24007390/raltegravir-emtricitabine-tenofovir-as-hiv-nonoccupational-post-exposure-prophylaxis-in-men-who-have-sex-with-men-safety-tolerability-and-adherence
#17
MULTICENTER STUDY
J McAllister, P Read, A McNulty, W W Y Tong, A Ingersoll, A Carr
OBJECTIVES: Three-drug nonoccupational post-exposure prophylaxis (NPEP) typically includes co-formulated emtricitabine-tenofovir (FTC-TDF) and a protease inhibitor. However, protease inhibitors can cause significant toxicities, can interact with prescribed and illicit drugs, and work late in the viral cycle. Agents that act before viral integration into host DNA may have efficacy advantages. Raltegravir (RAL) is a good candidate for NPEP as it has few side effects or drug interactions and acts prior to HIV integration...
January 2014: HIV Medicine
https://read.qxmd.com/read/23295867/clinical-and-hepatic-evaluation-in-adult-dengue-patients-a-prospective-two-month-cohort-study
#18
JOURNAL ARTICLE
Ricardo Tristão-Sá, Claire Fernandes Kubelka, Eliana Zandonade, Sônia Maria Oliveira Zagne, Natally de Souza Maciel Rocha, Luiza Oliveira Zagne, Nathália Félix Araújo, Beatriz Amin, Flávia Fazoli, Luiz José de Souza, Oswaldo Gonçalves Cruz, Rivaldo Venâncio da Cunha, Delso do Nascimento, Iris Bucher Froes, Rita Maria Ribeiro Nogueira
INTRODUCTION: To analyze the liver dysfunction and evolution of signs and symptoms in adult dengue patients during a two-month follow-up period. METHODS: A prospective cohort study was conducted in Campos dos Goytacazes, Rio de Janeiro, Brazil, from January to July, 2008. The evolution of laboratory and clinical manifestations of 90 adult dengue patients was evaluated in five scheduled visits within a two-month follow-up period. Twenty controls were enrolled for the analysis of liver function...
December 2012: Revista da Sociedade Brasileira de Medicina Tropical
https://read.qxmd.com/read/23274936/skeletal-muscle-toxicity-associated-with-raltegravir-based-combination-antiretroviral-therapy-in-hiv-infected-adults
#19
MULTICENTER STUDY
Frederick J Lee, Janaki Amin, Mark Bloch, Sarah L Pett, Debbie Marriott, Andrew Carr
OBJECTIVE/DESIGN: Raltegravir is uncommonly associated with rhabdomyolysis and grade 3-4 creatine kinase (CK) elevation. In this cross-sectional study, we compared the prevalence of skeletal muscle toxicity in HIV-infected adults receiving raltegravir with that of a control group. METHODS: Adults receiving combination antiretroviral therapy were recruited consecutively. Assessments included physical examination, an exercise questionnaire, and blood testing for CK, troponin T, and raltegravir trough levels...
April 15, 2013: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://read.qxmd.com/read/22350406/increase-in-serum-mitochondrial-creatine-kinase-levels-induced-by-tenofovir-administration
#20
JOURNAL ARTICLE
Dai Watanabe, Munehiro Yoshino, Hiroki Yagura, Kazuyuki Hirota, Hitoshi Yonemoto, Hiroki Bando, Keishiro Yajima, Yusuke Koizumi, Hiroshi Otera, Shinjiro Tominari, Yasuharu Nishida, Takeshi Kuwahara, Tomoko Uehira, Takuma Shirasaka
Recently, 2 monoclonal antibodies that specifically inhibit mitochondrial creatine kinase (MtCK) activity have been developed. In this study, we measured the serum MtCK activity in HIV-1-infected individuals (n = 100) by employing a novel method using these antibodies. The mean serum MtCK activity in 44 patients treated with highly active antiretroviral therapy (HAART) including tenofovir disoproxil fumarate (TDF) was 16.0 IU/L. The MtCK activity was significantly higher in patients receiving TDF than in those receiving HAART without TDF (3...
October 2012: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
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