Louisa P Selvadurai, Susan L Perlman, Tetsuo Ashizawa, George R Wilmot, Chiadi U Onyike, Liana S Rosenthal, Vikram G Shakkottai, Henry L Paulson, Sub H Subramony, Khalaf O Bushara, Sheng-Han Kuo, Cameron Dietiker, Michael D Geschwind, Alexandra B Nelson, Christopher M Gomez, Puneet Opal, Theresa A Zesiewicz, Trevor Hawkins, Talene A Yacoubian, Peggy C Nopoulos, Sharon J Sha, Peter E Morrison, Karla P Figueroa, Stefan M Pulst, Jeremy D Schmahmann
The Cerebellar Cognitive Affective/Schmahmann Syndrome (CCAS) manifests as impaired executive control, linguistic processing, visual spatial function, and affect regulation. The CCAS has been described in the spinocerebellar ataxias (SCAs), but its prevalence is unknown. We analyzed results of the CCAS/Schmahmann Scale (CCAS-S), developed to detect and quantify CCAS, in two natural history studies of 309 individuals Symptomatic for SCA1, SCA2, SCA3, SCA6, SCA7, or SCA8, 26 individuals Pre-symptomatic for SCA1 or SCA3, and 37 Controls...
January 2, 2024: Cerebellum