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https://www.readbyqxmd.com/read/28417005/reversibility-of-vasalgel%C3%A2-male-contraceptive-in-a-rabbit-model
#1
Donald Waller, David Bolick, Elaine Lissner, Christopher Premanandan, Gary Gamerman
BACKGROUND: Development of a non-hormonal long-acting reversible contraceptive for men could have a significant impact on reducing unintended pregnancies. Vasalgel™ is a high molecular weight polymer consisting of styrene-alt-maleic acid (SMA) dissolved in dimethyl sulfoxide being developed as a reversible male contraceptive device. It forms a hydrogel when implanted into the vasa deferentia, which prevents the passage of sperm. Previous studies in the rabbit have proven its efficacy, durability and rapid onset...
2017: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/28384430/low-doses-of-bisphenol-a-can-impair-postnatal-testicular-development-directly-without-affecting-hormonal-or-oxidative-stress-levels
#2
Fernanda M Ogo, Glaucia E M L Siervo, Géssica D Gonçalves, Rubens Cecchini, Flavia A Guarnier, Janete Ap Anselmo-Franci, Glaura S A Fernandes
Bisphenol A (BPA) is considered a potent endocrine disruptor, causing changes in the endocrine system due to its oestrogenic activity. Male individuals may be susceptible to endocrine, morphological and physiological alterations during testicular postnatal development. The aim of the present study was to evaluate whether exposure to BPA during the peripubertal period can damage testicular development. To this end, male Wistar rats were treated with BPA via gavage at doses of 20 or 200µgkg-1 on Postnatal Days (PND) 36-66...
April 7, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28384194/loss-of-slc9a3-decreases-cftr-protein-and-causes-obstructed-azoospermia-in-mice
#3
Ya-Yun Wang, Ying-Hung Lin, Yi-No Wu, Yen-Lin Chen, Yung-Chih Lin, Chiao-Yin Cheng, Han-Sun Chiang
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause cystic fibrosis (CF) and are associated with congenital bilateral absence of the vas deferens (CBAVD), which is the major cause of infertility in male patients with CF. However, most Taiwanese patients with CBAVD do not carry major CFTR mutations. Some patients have a single copy deletion of the solute carrier family 9 isoform 3 (SLC9A3) gene. SLC9A3 is a Na+/H+ exchanger, and depleted Slc9a3 in male mice causes infertility due to the abnormal dilated lumen of the rete testis and efferent ductules...
April 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28383520/structure-and-conformation-activity-studies-of-nociceptin-orphanin-fq-receptor-dimeric-ligands
#4
Salvatore Pacifico, Alfonso Carotenuto, Diego Brancaccio, Ettore Novellino, Erika Marzola, Federica Ferrari, Maria Camilla Cerlesi, Claudio Trapella, Delia Preti, Severo Salvadori, Girolamo Calò, Remo Guerrini
The peptide nociceptin/orphanin FQ (N/OFQ) and the N/OFQ receptor (NOP) constitute a neuropeptidergic system that modulates various biological functions and is currently targeted for the generation of innovative drugs. In the present study dimeric NOP receptor ligands with spacers of different lengths were generated using both peptide and non-peptide pharmacophores. The novel compounds (12 peptide and 7 nonpeptide ligands) were pharmacologically investigated in a calcium mobilization assay and in the mouse vas deferens bioassay...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28376421/congenital-absence-of-vas-deferens-and-ectopic-kidney
#5
Alobaidi Salwan, Alhmooze Abdelrahman
INTRODUCTION: Congenital absence of the vas deferens (CUAVD) is a rare clinical entity, usually discovered accidently during surgical procedures of the urogenital zone, CUAVD has the prevalence of 0.5-1.0% in male population and it is associated with various forms of congenital genitourinary malformations like renal agenesis. we present a case of a 21 years old, male, managed in our private hospital for varicoceles and discovered to have CUAVD and ectopic kidney. PRESENTATION OF CASE: A 21 years old male, with no significant medical or surgical history presented to our out-patient clinic complaining of scrotal heaviness and pain...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28369509/revisiting-the-human-seminiferous-epithelium-cycle
#6
F Nihi, M L M Gomes, F A R Carvalho, A B Reis, R Martello, R C N Melo, F R C L Almeida, H Chiarini-Garcia
STUDY QUESTION: Can all types of testicular germ cells be accurately identified by microscopy techniques and unambiguously distributed in stages of the human seminiferous epithelium cycle (SEC)? SUMMARY ANSWER: By using a high-resolution light microscopy (HRLM) method, which enables an improved visualization of germ cell morphological features, we identified all testicular germ cells in the seminiferous epithelium and precisely grouped them in six well-delimitated SEC stages, thus providing a reliable reference source for staging in man...
March 28, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28369153/detailed-analysis-of-the-male-reproductive-system-in-a-potential-bio-indicator-species-the-marine-invertebrate-galeolaria-caespitosa-polychaeta-serpulidae
#7
Yonggang Lu, Robert John Aitken, Minjie Lin
For the first time, this study has systemically investigated the male reproductive system in a sessile broadcast-spawning marine invertebrate, Galeolaria caespitosa (Polychaeta: Serpulidae), which has significant potential as a bio-indicator species of coastal marine pollution. The abdomen of G. caespitosa was divided by intersegmental septa into over 80 trunk segments. Each segment served as a germinal chamber with a C-shaped gonadal arrangement consisting of several distinct compartments: a seminiferous epithelium (SE) compartment located in the centre of the chamber, with each of its two ends connecting to a nurse cell (NC) compartment and then an efferent duct (ED) compartment...
2017: PloS One
https://www.readbyqxmd.com/read/28350489/redescription-and-molecular-assessment-of-relationships-among-three-species-of-echeneibothrium-rhinebothriidea-echeneibothriidae-parasitizing-the-yellownose-skate-dipturus-chilensis-in-chile
#8
Veronica M Bueno, Janine N Caira
Much progress has recently been made towards revising the taxonomic assignments of genera originally classified in the polyphyletic "Tetraphyllidea". Many of these genera, including Echeneibothrium van Beneden, 1850, were accommodated in the order Rhinebothriidea. However, beyond this larger taxonomic action, little work has been conducted on this genus over the last 50 yrs. As a consequence, the criteria employed for characterizing species of Echeneibothrium have lagged behind those typically employed in more modern descriptions of elasmobranch-hosted cestode taxa...
March 10, 2017: Journal of Parasitology
https://www.readbyqxmd.com/read/28341579/beware-the-looping-vas-deferens-in-orchidopexy
#9
Thomas P Cundy, Day Way Goh
A looping vas deferens may be present in up to 20% of undescended testes located within or proximal to the inguinal canal. This associated abnormality is vulnerable to transection during orchidopexy. We present an example of a very long looping vas to emphasize the importance of inspection for this anomaly, and demonstrate the extreme extent that a looping vas may extend. Identification of the vas among cord structures may provide false reassurance of normal ductal anatomy. Examination for a looping vas by inspecting structures caudal to the testis should occur at an early opportunity during orchidopexy to avoid inadvertent transection...
March 21, 2017: Urology
https://www.readbyqxmd.com/read/28335493/melatonin-mt%C3%A2-and-mt%C3%A2-receptors-in-the-ram-reproductive-tract
#10
Marta González-Arto, David Aguilar, Elena Gaspar-Torrubia, Margarita Gallego, Melissa Carvajal-Serna, Luis V Herrera-Marcos, Edith Serrano-Blesa, Thais Rose Dos Santos Hamilton, Rosaura Pérez-Pé, Teresa Muiño-Blanco, José A Cebrián-Pérez, Adriana Casao
Some melatonin functions in mammals are exerted through MT₁ and MT₂ receptors. However, there are no reports of their presence in the reproductive tract of the ram, a seasonal species. Thus, we have investigated their existence in the ram testis, epididymis, accessory glands and ductus deferens. Real-time polymerase chain reaction (qPCR) revealed higher levels of m-RNA for both receptors in the testis, ampulla, seminal vesicles, and vas deferens, than in the other organs of the reproductive tract (p < 0...
March 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28289973/a-novel-laparoscopic-technique-for-anorectal-malformation-with-low-recto-bulbar-fistulae
#11
Mei Diao, Long Li, Kao-Ping Guan, Zhen Zhang, Wei Cheng
BACKGROUND: The repair of anorectal malformation (ARM) with low recto-bulbar fistula (bowel-to-skin distance: 1-1.5 cm) is contraindicated for laparoscopy due to the difficulty in exposing the fistulae. Posterior or anterior sagittal anorectoplasty is thus conventionally carried out for low recto-bulbar fistula repair. However, these procedures carry the potential risk of wound infection/dehiscence and incontinence. We have developed a single-incision laparoscopic-assisted perineal anorectoplasty (SILPARP) technique...
March 13, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28265530/discontinued-splenogonadal-fusion-and-bilateral-empty-scrotum-in-an-18-month-old-boy
#12
Ahmed Abokrecha, Ameera Almatrfi
Splenogonadal fusion is a rare benign congenital anomaly defined as the presence of splenic tissue adherent to gonads. It was first described in 1883 by Bostroem, a German pathologist. We present a case of an 18-month-old boy who was referred as a case of bilateral empty scrotum since birth. During routine laparoscopic exploration, right vas deferens and testicular vessels were entering the right internal inguinal ring so right inguinal exploration was done, which revealed blind ending vas deferens and testicular vessels and the left testis was found intra-abdominally near the left internal ring with a mass on its upper pole...
February 2017: European Journal of Pediatric Surgery Reports
https://www.readbyqxmd.com/read/28258018/left-sided-varicocele-as-a-rare-presentation-of-may-thurner-syndrome
#13
J R Stern, V I Patel, D E Cafasso, N B Gentile, A J Meltzer
INTRODUCTION: May-Thurner syndrome (MTS), the clinical sequelae of left iliac vein compression between the right iliac artery and the spine, is an accepted cause of lower extremity edema and venous thromboembolism. It is more prevalent in younger women, and typically presents with left lower extremity symptoms. Atypical presentations such as right-sided symptoms, chronic pelvic pain, and even fatal venous rupture have been reported. Here we describe iliac vein compression presenting as a chronic left-sided testicular varicocele...
February 28, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28246982/transcriptomic-analysis-of-male-black-tiger-shrimp-penaeus-monodon-after-polychaete-feeding-to-enhance-testicular-maturation
#14
Rungnapa Leelatanawit, Umaporn Uawisetwathana, Amornpan Klanchui, Jutatip Khudet, Suwanchai Phomklad, Somjai Wongtriphop, Pikul Jiravanichpaisal, Nitsara Karoonuthaisiri
To reveal molecular mechanism of how polychaetes enhanced reproductive maturation in the male black tiger shrimp (Penaeus monodon), transcriptomic profiles of male reproductive organs (testes and vas deferens) between polychaete-fed and commercial pellet-fed male brooders were compared using cDNA microarray. The overall profiles were distinguishingly different between the two feed groups as well as between testes and vas deferens. Additionally, six of 11 differentially expressed gene identified by the microarray (HNRPUL1 and GCP4 in testes, MAT2B, CDC16, and CSN5 in vas deferens, and SLD5 in both organs) were validated by quantitative real-time PCR (qPCR) and found to exhibit significantly higher expression levels in polychaete-fed shrimp than those in commercial pellet-fed shrimp...
February 28, 2017: Marine Biotechnology
https://www.readbyqxmd.com/read/28224697/antioxidant-treatment-ameliorates-diabetes-induced-dysfunction-of-the-vas-deferens-in-a-rat-model
#15
P Tsounapi, M Honda, F Dimitriadis, S Shimizu, T Shiomi, K Hikita, M Saito, S Tomita, N Sofikitis, A Takenaka
Diabetes mellitus (DM) affects the male ejaculatory function. This study was designed to evaluate the role of oxidative stress in the development of diabetes-induced dysfunction of vas deferens (VD) in the rat. DM was induced by streptozotocin in 40 male Wistar rats. Subsequently, the diabetic animals were divided into three groups: DM group, DM + Eda group and DM + Tau group. These groups were administered saline, edaravone and taurine, respectively, daily for 4 weeks. Another group of ten rats served as a control group...
February 22, 2017: Andrologia
https://www.readbyqxmd.com/read/28196530/r248g-cystic-fibrosis-transmembrane-conductance-regulator-mutation-in-three-siblings-presenting-with-recurrent-acute-pancreatitis-and-reproductive-issues-a-case-series
#16
Seiichi Villalona, Guillermo Glover-López, Juan Antonio Ortega-García, Rosa Moya-Quiles, Pedro Mondejar-López, Maria C Martínez-Romero, Mariano Rigabert-Montiel, María D Pastor-Vivero, Manuel Sánchez-Solís
BACKGROUND: Mutational combinations of the cystic fibrosis transmembrane conductance regulator, CFTR, gene have different phenotypic manifestations at the molecular level with varying clinical consequences for individuals possessing such mutations. Reporting cystic fibrosis transmembrane conductance regulator mutations is important in understanding the genotype-phenotype correlations and associated clinical presentations in patients with cystic fibrosis. Understanding the effects of mutations is critical in developing appropriate treatments for individuals affected with cystic fibrosis, non-classic cystic fibrosis, or cystic fibrosis transmembrane conductance regulator-related disorders...
February 15, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28191316/the-contraceptive-efficacy-of-intravas-injection-of-vasalgel%C3%A2-for-adult-male-rhesus-monkeys
#17
Angela Colagross-Schouten, Marie-Josee Lemoy, Rebekah I Keesler, Elaine Lissner, Catherine A VandeVoort
BACKGROUND: Options for male contraception are limited. The purpose of this study was to use a nonhuman primate model to evaluate Vasalgel™, a high molecular weight polymer being developed as a contraceptive device for men. METHODS: Sixteen adult male rhesus monkeys received intravas injections of Vasalgel, consisting of 25% styrene maleic acid in dimethyl sulfoxide. After a one-week recovery, males were returned to outdoor group housing, which included at least 3 and up to 9 intact, breeding females with a successful reproductive history...
2017: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/28166947/effects-of-heat-stress-on-some-reproductive-parameters-of-male-cavie-cavia-porcellus-and-mitigation-strategies-using-guava-psidium-guajava-leaves-essential-oil
#18
Ferdinand Ngoula, Maryvonne Guemdjo Tekam, Augustave Kenfack, Cyrille D'Alex Tadondjou Tchingo, Sandrine Nouboudem, Herman Ngoumtsop, Borice Tsafack, Alexis Teguia, Pierre Kamtchouing, Marco Galeotti, Joseph Tchoumboue
Climate changes, particularly the increase of temperature are among the main causes behind the decline of fertility in humans as well as animals. In this study, the effects of heat stress on some reproductive parameters of male cavies and mitigation strategies using guava leaves essential oil (GLEO) were studied. For this purpose, 40 male cavies aged 2.5-3 months and weighing between 348 and 446g were divided into 4 groups of 10 animals each and subjected to the following temperatures: Ambient temperature (20-25°C) for the control group, 35°C for group 1, 45°C for group 2 and 45°C+100µl GLEO/kg body weight, administered by gavage to animals for group 3...
February 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28163192/sperm-ultrastructure-of-shrimp-from-family-penaeidae-crustacea-dendrobranchiata-in-a-phylogenetic-context
#19
Tavani Rocha Camargo, Natalia Rossi, Antonio L Castilho, Rogério C Costa, Fernando L Mantelatto, Fernando José Zara
We describe the sperm ultrastructure of six penaeid species, including at least one member of each tribe (Penaeini, Parapenaeini and Trachypenaeini). Fragments of the vas deferens of the Penaeidae Farfantepenaeus brasiliensis, Farfantepenaeus paulensis, Litopenaeus schmitti, Parapenaeus americanus, Rimapenaeus constrictus and Xiphopenaeus kroyeri were fixed and processed according to the routine for transmission electron microscopy. The morphological results were contextualized in an evolutionary perspective using molecular markers for the phylogenetic reconstruction of this group...
March 27, 2017: Arthropod Structure & Development
https://www.readbyqxmd.com/read/28161359/is-there-a-role-for-serratia-marcescens-in-male-infertility-an-experimental-study
#20
Kalpana Rana, Deepali Thaper, Vijay Prabha
OBJECTIVE: Establishment of a male BALB/c mouse model to study the role of sperm impairing S. marcescens on mouse reproductive potential. The current study can add to use of reliable animal models to provide a noteworthy evidence for the microbial cause of infertility. METHODS: The mice in the test groups II, III, IV were intraperitoneally administered with different doses (10(4), 10(6) or 10(8) cfu) of S. marcescens whereas, group I serving as control, received PBS, for 10 consecutive days...
April 2017: Microbial Pathogenesis
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