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https://www.readbyqxmd.com/read/28645010/a-rare-case-of-male-pseudohermaphroditism-persistent-mullerian-duct-syndrome-with-transverse-testicular-ectopia-case-report-and-review-of-literature
#1
Aashish Rajesh, Mohammed Farooq
INTRODUCTION: Persistent Mullerian duct syndrome (PMDS) is a rare type of male pseudohermaphroditism. Transverse testicular ectopia (TTE) is characterized by one testis moving to the opposite side and both testes traversing the same inguinal canal. CASE PRESENTATION: An 11-month-old boy presented with bilateral cryptorchidism. The left testis was not palpable; the right testis was canalicular with a right inguinal hernia. Ultrasound showed both testes located in the right inguinal canal...
June 15, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28642060/microsurgically-assisted-inguinal-hernia-repair-and-simultaneous-male-fertility-procedures-rationale-technique-and-outcomes
#2
Michael L Schulster, Matthew R Cohn, Bobby B Najari, Marc Goldstein
PURPOSE: Inguinal herniorrhaphy is the most common general surgical procedure. It is associated with frequent complications such as recurrence (1.9% with mesh), post-operative hematoma (4.5%), reduced sensation (0 - 42.8%), chronic post-operative pain (5.1%), vasal injury (0.1 - 0.53%) and infection (3 - 6%)(1-5). Drawing on our experience utilizing the operating microscope for varicocelectomy, vasectomy reversal and repair of iatrogenic vasal obstruction from hernia repair, we employed it for inguinal hernia repair...
June 19, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28639921/multisystem-imaging-findings-of-cystic-fibrosis-in-adults-recognizing-typical-and-atypical-patterns-of-disease
#3
Sarah Averill, Meghan G Lubner, Christine O Menias, Sanjeev Bhalla, Vincent M Mellnick, Tabassum A Kennedy, Perry J Pickhardt
OBJECTIVE: There is an expanding and increasingly heterogeneous population of adult patients with cystic fibrosis (CF). Although CF is usually diagnosed in children with progressive multisystem involvement, up to 7% of CF cases are currently diagnosed de novo in adults with subtle manifestations distinct from the typical features of classic CF. The purpose of this article is to present the wide spectrum of CF in adults, including both classic and nonclassic variants, with an emphasis on the nonclassic imaging findings...
July 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28599657/comparison-of-methods-for-calculating-the-health-costs-of-endocrine-disrupters-a-case-study-on-triclosan
#4
Radka Prichystalova, Jean-Baptiste Fini, Leonardo Trasande, Martine Bellanger, Barbara Demeneix, Laura Maxim
BACKGROUND: Socioeconomic analysis is currently used in the Europe Union as part of the regulatory process in Regulation Registration, Evaluation and Authorisation of Chemicals (REACH), with the aim of assessing and managing risks from dangerous chemicals. The political impact of the socio-economic analysis is potentially high in the authorisation and restriction procedures, however, current socio-economic analysis dossiers submitted under REACH are very heterogeneous in terms of methodology used and quality...
June 9, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28591404/sexual-transmission-of-american-trypanosomiasis-in-humans-a-new-potential-pandemic-route-for-chagas-parasites
#5
Perla F Araujo, Adriana B Almeida, Carlos F Pimentel, Adriano R Silva, Alessandro Sousa, Sebastião A Valente, Vera C Valente, Manuela M Britto, Ana C Rosa, Rozeneide M Alves, Luciana Hagström, Antonio Rl Teixeira
BACKGROUND: The Trypanosoma cruzi infection endemic in Latin America has now spread to several countries across four continents; this endemic involves triatomine vector-free protists. We hypothesised that the sexual transmission of T. cruzi contributes to the ongoing spread of Chagas disease. OBJECTIVES: A short-term longitudinal study was conducted to evaluate this hypothesis. METHODS: The study population comprised 109 subjects from four families, among whom 21 had been diagnosed with acute Chagas disease by direct parasitological analysis...
June 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28581201/grape-juice-concentrate-alleviates-epididymis-and-sperm-damage-in-cadmium-intoxicated-rats
#6
Celina de A Lamas, Livia Cuquetto-Leite, Emanueli do Nascimento da Silva, Bruna F Thomazini, Gabriel da S Cordeiro, Fabrícia de S Predes, Andrea P B Gollücke, Heidi Dolder
The possibility of long-term grape juice concentrate (GJC) consumption conferring a protective effect against cadmium (Cd)-induced damage to the epididymis, completely preserving sperm profile, was evaluated here for the first time in the scientific literature. Male Wistar rats (n = 6/per group) received an intraperitoneal Cd injection (1.2 mg/Kg) at age 80 days and GJC (2 g/Kg) by gavage from 50 days until 136 days old. Groups receiving either Cd or GJC were added. An intraperitoneal injection of saline (0...
June 5, 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/28576637/the-diagnosis-of-cystic-fibrosis
#7
Kris De Boeck, Francois Vermeulen, Lieven Dupont
Establishing the diagnosis of cystic fibrosis (CF) is straight forward in the majority of patients: they present with a clear clinical picture (most frequently chronic respiratory symptoms plus malabsorption), the sweat chloride value is>60mmol/L and two known disease causing CFTR mutations are identified. In less than 5% of subjects, mainly those with a milder or limited phenotype, the diagnostic process is more complex, because initial diagnostic test results are inconclusive: sweat chloride concentration in the intermediate range, less than 2 CF causing mutations identified or both...
May 30, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28551604/abdominoscrotal-hydrocele-in-an-infant-boy
#8
Eliana Costantino, George S Ganesan, J Chadwick Plaire
Abdominoscrotal hydrocele (ASH) is the rarest type of hydrocele. This condition is characterised by a large abdominal and scrotal component connected by an isthmus within the inguinal canal. The incidence among the paediatric population is reported to be less than 3%, although it might be underdiagnosed. Several theories have been proposed in the literature but the aetiology of ASH remains unknown. Diagnosis can be made clinically and confirmed by ultrasound. Spontaneous resolution is rare and long-standing ASH may lead to complications, thus early surgical intervention is recommended...
May 27, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28541268/scrotal-ultrasonic-features-of-congenital-bilateral-absence-of-vas-deferens
#9
Jun Liu, Zhiqian Wang, MingYang Zhou, Min Li, Weiwei Zhan
OBJECTIVE: This article discusses scrotal ultrasonic features of patients with a congenital bilateral absence of the vas deferens (CBAVD). METHODS: Thirty-six patients with CBAVD were examined to obtain image characteristics of the bilateral testicle and epididymis by ultrasound. Each patient received a pathological examination of the sperm by percutaneous epididymal biopsy. RESULTS: Scrotal ultrasonic features were as follows: (1) testicular volumes were normal in all the 36 patients; (2) 21% (15/72) of the heads of epididymis, 67% (48/72) of the heads and bodies of epididymis, and 12% (9/72) of the heads, bodies, and tails of epididymis could be shown in the 72 epididymides of the 36 patients; (3) cystic or tubular dilation of the epididymis was obvious in all 72 abnormal epididymides; and (4) bilateral vas deferens could not be found in these patients...
June 2017: Ultrasound Quarterly
https://www.readbyqxmd.com/read/28514260/differential-diagnostic-value-of-obstructive-and-nonobstructive-azoospermia-by-scrotal-ultrasound
#10
Jun Liu, Zhiqian Wang, Min Li, Mingyang Zhou, Weiwei Zhan
Our objective was to assess the differential diagnostic value of classification of obstructive versus nonobstructive azoospermia by scrotal ultrasound. Forty patients with azoospermia were selected for our study (ages, 23-35; average, 29 ± 5.34 years). Patients were divided into the obstructive (17) or nonobstructive (23) azoospermia category. Twenty "healthy" volunteers were selected for the control group. We observed the testis, epididymis, and vas deferens in all subjects. Testicular volumes were calculated and compared with the control group for both obstructive and nonobstructive groups...
May 16, 2017: Ultrasound Quarterly
https://www.readbyqxmd.com/read/28502630/new-opioid-receptor-antagonist-naltrexone-14-o-sulfate-synthesis-and-pharmacology
#11
Ferenc Zádor, Kornél Király, András Váradi, Mihály Balogh, Ágnes Fehér, Dóra Kocsis, Anna I Erdei, Erzsébet Lackó, Zoltán S Zádori, Sándor Hosztafi, Béla Noszál, Pál Riba, Sándor Benyhe, Susanna Fürst, Mahmoud Al-Khrasani
Opioid antagonists, naloxone and naltrexone have long been used in clinical practice and research. In addition to their low selectivity, they easily pass through the blood-brain barrier. Quaternization of the amine group in these molecules, (e.g. methylnaltrexone) results in negligible CNS penetration. In addition, zwitterionic compounds have been reported to have limited CNS access. The current study, for the first time gives report on the synthesis and the in vitro [competition binding, G-protein activation, isolated mouse vas deferens (MVD) and mouse colon assay] pharmacology of the zwitterionic compound, naltrexone-14-O-sulfate...
May 11, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28501111/laparoscopic-dissection-and-division-of-distal-fistula-in-boys-with-rectourethral-fistula
#12
Chen Wang, Mei Diao, Long Li, Shuli Liu, Zheng Chen, Xu Li, Wei Cheng
BACKGROUND: Congenital rectourethral fistula (RUF) is the most common form of anorectal malformations found in boys. The aim of this study is to review our experience with dissection and division of distal fistula using laparoscopic surgery in the management of RUF, especially rectourethral bulbar fistula. METHODS: One hundred and two consecutive boys with congenital RUF who underwent conventional or single-incision laparoscopic surgery between July 2008 and June 2015 were enrolled in the study...
May 1, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28479781/polyorchidism-unilateral-one-atrophic-undescended-double-testicles
#13
Mehmet Balasar, Mehmet Giray Sönmez, Pembe Oltulu, Abdülkadir Kandemir, Mehmet Kılıç, Yunus Emre Göğer, Mehmet Mesut Pişkin
Polyorchidism is a very rare genitourinary anomaly defined with the presence of more than two testicles. Polyorchidism is associated up to 40% with undescended testicles. The present report is about an incidentally detected triorchidism case with unilateral, one atrophic undescended double testicles. A 4-year-old child, diagnosed with undescended left testicle revealed during orchiopexy polyorchidism with distinct epididymis and vas deferens. Whereas one of the testicles was in regular size; the other two were atrophic...
April 2017: Urology Annals
https://www.readbyqxmd.com/read/28450692/the-ethyl-acetate-fraction-of-a-methanolic-extract-of-unripe-noni-morinda-citrifolia-linn-fruit-exhibits-a-biphasic-effect-on-the-dopaminergic-system-in-mice
#14
Vijayapandi Pandy, Megala Narasingam, Kamini Vijeepallam, Syam Mohan, Vasudevan Mani, Zahurin Mohamed
In earlier ex vivo studies, we reported the biphasic effect of a methanolic extract of unripe Morinda citrifolia fruit (MMC) on dopamine-induced contractility in isolated rat vas deferens preparations. The present in vivo study was designed and undertaken to further explore our earlier ex vivo findings. This study examined the effect of the ethyl acetate fraction of a methanolic extract of unripe Morinda citrifolia Linn. fruit (EA-MMC; 5-100 mg/kg, p.o.) on the dopaminergic system using mouse models of apomorphine-induced climbing time and climbing behavior, methamphetamine-induced stereotypy (sniffing, biting, gnawing, and licking) and haloperidol-induced catalepsy using the bar test...
April 26, 2017: Experimental Animals
https://www.readbyqxmd.com/read/28417005/reversibility-of-vasalgel%C3%A2-male-contraceptive-in-a-rabbit-model
#15
Donald Waller, David Bolick, Elaine Lissner, Christopher Premanandan, Gary Gamerman
BACKGROUND: Development of a non-hormonal long-acting reversible contraceptive for men could have a significant impact on reducing unintended pregnancies. Vasalgel™ is a high molecular weight polymer consisting of styrene-alt-maleic acid (SMA) dissolved in dimethyl sulfoxide being developed as a reversible male contraceptive device. It forms a hydrogel when implanted into the vasa deferentia, which prevents the passage of sperm. Previous studies in the rabbit have proven its efficacy, durability and rapid onset...
2017: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/28384430/low-doses-of-bisphenol-a-can-impair-postnatal-testicular-development-directly-without-affecting-hormonal-or-oxidative-stress-levels
#16
Fernanda M Ogo, Glaucia E M L Siervo, Géssica D Gonçalves, Rubens Cecchini, Flavia A Guarnier, Janete Ap Anselmo-Franci, Glaura S A Fernandes
Bisphenol A (BPA) is considered a potent endocrine disruptor, causing changes in the endocrine system due to its oestrogenic activity. Male individuals may be susceptible to endocrine, morphological and physiological alterations during testicular postnatal development. The aim of the present study was to evaluate whether exposure to BPA during the peripubertal period can damage testicular development. To this end, male Wistar rats were treated with BPA via gavage at doses of 20 or 200µgkg-1 on Postnatal Days (PND) 36-66...
April 7, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28384194/loss-of-slc9a3-decreases-cftr-protein-and-causes-obstructed-azoospermia-in-mice
#17
Ya-Yun Wang, Ying-Hung Lin, Yi-No Wu, Yen-Lin Chen, Yung-Chih Lin, Chiao-Yin Cheng, Han-Sun Chiang
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause cystic fibrosis (CF) and are associated with congenital bilateral absence of the vas deferens (CBAVD), which is the major cause of infertility in male patients with CF. However, most Taiwanese patients with CBAVD do not carry major CFTR mutations. Some patients have a single copy deletion of the solute carrier family 9 isoform 3 (SLC9A3) gene. SLC9A3 is a Na+/H+ exchanger, and depleted Slc9a3 in male mice causes infertility due to the abnormal dilated lumen of the rete testis and efferent ductules...
April 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28383520/structure-and-conformation-activity-studies-of-nociceptin-orphanin-fq-receptor-dimeric-ligands
#18
Salvatore Pacifico, Alfonso Carotenuto, Diego Brancaccio, Ettore Novellino, Erika Marzola, Federica Ferrari, Maria Camilla Cerlesi, Claudio Trapella, Delia Preti, Severo Salvadori, Girolamo Calò, Remo Guerrini
The peptide nociceptin/orphanin FQ (N/OFQ) and the N/OFQ receptor (NOP) constitute a neuropeptidergic system that modulates various biological functions and is currently targeted for the generation of innovative drugs. In the present study dimeric NOP receptor ligands with spacers of different lengths were generated using both peptide and non-peptide pharmacophores. The novel compounds (12 peptide and 7 nonpeptide ligands) were pharmacologically investigated in a calcium mobilization assay and in the mouse vas deferens bioassay...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28376421/congenital-absence-of-vas-deferens-and-ectopic-kidney
#19
Alobaidi Salwan, Alhmooze Abdelrahman
INTRODUCTION: Congenital absence of the vas deferens (CUAVD) is a rare clinical entity, usually discovered accidently during surgical procedures of the urogenital zone, CUAVD has the prevalence of 0.5-1.0% in male population and it is associated with various forms of congenital genitourinary malformations like renal agenesis. we present a case of a 21 years old, male, managed in our private hospital for varicoceles and discovered to have CUAVD and ectopic kidney. PRESENTATION OF CASE: A 21 years old male, with no significant medical or surgical history presented to our out-patient clinic complaining of scrotal heaviness and pain...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28369509/revisiting-the-human-seminiferous-epithelium-cycle
#20
F Nihi, M L M Gomes, F A R Carvalho, A B Reis, R Martello, R C N Melo, F R C L Almeida, H Chiarini-Garcia
STUDY QUESTION: Can all types of testicular germ cells be accurately identified by microscopy techniques and unambiguously distributed in stages of the human seminiferous epithelium cycle (SEC)? SUMMARY ANSWER: By using a high-resolution light microscopy (HRLM) method, which enables an improved visualization of germ cell morphological features, we identified all testicular germ cells in the seminiferous epithelium and precisely grouped them in six well-delimitated SEC stages, thus providing a reliable reference source for staging in man...
June 1, 2017: Human Reproduction
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