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https://www.readbyqxmd.com/read/29331846/functional-neuroimaging-in-rasmussen-syndrome
#1
Ichiro Kuki, Kazumi Matsuda, Yuko Kubota, Tetsuhiro Fukuyama, Yukitoshi Takahashi, Yushi Inoue, Haruo Shintaku
PURPOSE: For a diagnosis of Rasmussen syndrome (RS), clinical course together with electroencephalography (EEG) and magnetic resonance imaging (MRI) findings are considered important, but there are few reports on functional neuroimaging. This study investigated cerebral blood flow (CBF)-single photon emission computed tomography (SPECT), central benzodiazepine receptor (BZR)-SPECT, and fluorine-18 fluorodeoxy glucose-positron emission tomography (FDG-PET) in RS patients, and correlated neuroimaging results with MRI and pathological findings...
January 5, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29330718/spect-ct-adds-distinct-lymph-node-basins-and-influences-radiologic-findings-and-surgical-approach-for-sentinel-lymph-node-biopsy-in-head-and-neck-melanoma
#2
Becky B Trinh, Brandon C Chapman, Ana Gleisner, Jennifer J Kwak, Rustain Morgan, Martin D McCarter, Csaba Gajdos, Nicole Kounalakis
BACKGROUND: Planar lymphoscintigraphy (PL) has a lower detection rate of sentinel lymph nodes (SLNs) in head and neck melanoma compared with other sites. We assessed situations when single-photon emission computed tomography/computed tomography (SPECT/CT) identified nodes not seen by PL. We also evaluated the impact of SPECT/CT on surgical approach and oncologic outcomes. METHODS: Patients who underwent SLN biopsy (SLNB) for head and neck melanoma with PL and SPECT/CT between November 2011 and December 2016 were included...
January 12, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29330100/osteoarthritis-year-in-review-2017-updates-on-imaging-advancements
#3
REVIEW
Nima Hafezi-Nejad, Shadpour Demehri, Ali Guermazi, John A Carrino
OBJECTIVE: This narrative review covers original research publications related to imaging advancements in osteoarthritis (OA) published in the English language between 1st April 2016 and 30th April 2017. METHODS: Relevant human studies (excluding pre-clinical and in-vitro studies), were searched and selected from PubMed database using the search terms of "osteoarthritis (OA)" in combination with "radiography", "magnetic resonance imaging (MRI)", "computed tomography (CT)", "ultrasound", "positron emission tomography (PET)," "single-photon emission computed tomography (SPECT)," and "scintigraphy"...
January 9, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29329716/gelatin-hydroxyapatite-calcium-sulphate-based-biomaterial-for-long-term-sustained-delivery-of-bone-morphogenic-protein-2-and-zoledronic-acid-for-increased-bone-formation-in-vitro-and-in-vivo-carrier-properties
#4
Deepak Bushan Raina, David Larsson, Filip Mrkonjic, Hanna Isaksson, Ashok Kumar, Lars Lidgren, Magnus Tägil
In this study, a novel macroporous composite biomaterial consisting of gelatin-hydroxyapatite-calcium sulphate for delivery of bone morphogenic protein-2 (rhBMP-2) and zoledronic acid (ZA) has been developed. The biomaterial scaffold has a porous structure and functionalization of the scaffold with rhBMP-2 induces osteogenic differentiation of MC3T3-e1 cells seen by a significant increase in biochemical and genetic markers of osteoblastic differentiation. In-vivo muscle pouch experiments showed higher mineralization using scaffold+rhBMP-2 when compared to an approved absorbable collagen sponge (ACS)+rhBMP-2 as verified by micro-CT...
January 9, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29327129/quantification-of-osteoblastic-activity-in-epiphyseal-growth-plates-by-quantitative-bone-spect-ct
#5
Tomohiko Yamane, Ichiei Kuji, Akira Seto, Ichiro Matsunari
OBJECTIVE: Quantifying the function of the epiphyseal plate is worthwhile for the management of children with growth disorders. The aim of this retrospective study was to quantify the osteoblastic activity at the epiphyseal plate using the quantitative bone SPECT/CT. MATERIALS AND METHODS: We enrolled patients under the age of 20 years who received Tc-99m hydroxymethylene diphosphonate bone scintigraphy acquired by a quantitative SPECT/CT scanner. The images were reconstructed by ordered subset conjugate-gradient minimizer, and the uptake on the distal margin of the femur was quantified by peak standardized uptake value (SUVpeak)...
January 11, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29326358/targeted-alpha-therapy-of-mcrpc-with-225actinium-psma-617-swimmer-plot-analysis-suggests-efficacy-regarding-duration-of-tumor-control
#6
Clemens Kratochwil, Frank Bruchertseifer, Hendrik Rathke, Markus Hohenfellner, Frederik L Giesel, Uwe Haberkorn, Alfred Morgenstern
The aim of this evaluation is to identify first indicators regarding the efficacy of 225Ac-PSMA-617 therapy in a retrospectively analyzed group of patients. Methods: Forty patients with metastatic castration-resistant prostate cancer were selected for treatment with 3 cycles of 100 kBq/kgBW 225Ac-PSMA-617 in 2 months intervals. Prostate-specific antigen (PSA) and blood cell count were measured every 4 weeks. Prostate-specific membrane antigen (PSMA)-PET/CT or PSMA-SPECT/CT were used for baseline staging and imaging follow-up at month six...
January 11, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29323252/clinical-value-of-99mtc-3prgd2-spect-ct-in-differentiated-thyroid-carcinoma-with-negative-131i-whole-body-scan-and-elevated-thyroglobulin-level
#7
Rui Gao, Guang-Jian Zhang, Yuan-Bo Wang, Yan Liu, Fan Wang, Xi Jia, Yi-Qian Liang, Ai-Min Yang
The aim of this study was to assess the usefulness of integrin imaging with 99mTc-PEG4-E[PEG4-c(RGDfK)]2 (99mTc-3PRGD2) single photon emission computed tomography (SPECT)/computed tomography (CT) in detecting recurrent disease in patients with differentiated thyroid cancer (DTC), negative radioiodine whole-body scan (WBS) and high serum thyroglobulin (Tg). Thirty-seven patients who underwent total thyroidectomy followed by radioactive iodine ablation and had negative radioiodine WBS but elevated Tg levels were included...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29322344/deadtime-effects-in-quantification-of-177lu-activity-for-radionuclide-therapy
#8
Carlos F Uribe, Pedro L Esquinas, Marjorie Gonzalez, Wei Zhao, Jesse Tanguay, Anna Celler
BACKGROUND: The aim of this study was to investigate the deadtime (DT) effects that are present in 177Lu images acquired after radionuclide therapy injection, assess differences in DT based on the full spectrum and the photopeak-only measurements, and design a method to correct for the deadtime losses. A Siemens SymbiaT SPECT/CT camera with a medium energy collimator was used. A 295-mL bottle was placed off-center inside a large cylinder filled with water, and 177Lu activity was sequentially added up to a maximum of 9...
January 11, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/29320705/an-adipose-tissue-atlas-an-image-guided-identification-of-human-like-bat-and-beige-depots-in-rodents
#9
Fang Zhang, Guiyang Hao, Mengle Shao, Kien Nham, Yu An, Qiong Wang, Yi Zhu, Christine M Kusminski, Gedaa Hassan, Rana K Gupta, Qiwei Zhai, Xiankai Sun, Philipp E Scherer, Orhan K Oz
[18F]Fluorodeoxyglucose-PET/CT (18F-FDG-PET/CT) imaging has been invaluable for visualizing metabolically active adipose tissues in humans with potential anti-diabetic and anti-obesity effects. To explore whether mice display human-like fat depots in anatomically comparable regions, we mapped fat depots using glucose or fatty acid imaging tracers, such as 18F-FDG through PET/CT or [123/125I]-β-methyl-p-iodophenyl-pentadecanoic acid with SPECT/CT imaging, to analogous depots in mice. Using this type of image analysis with both probes, we define a large number of additional areas of high metabolic activity corresponding to novel fat pads...
January 9, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29319547/the-role-of-molecular-imaging-in-the-characterization-of-renal-masses
#10
Alexa R Meyer, Mohamad E Allaf, Steven P Rowe, Michael A Gorin
PURPOSE OF REVIEW: To explore the role of molecular imaging in the characterization of renal masses. RECENT FINDINGS: Incidentally detected renal masses exhibit variable malignant potential related to their underlying histology. Patients presenting with a renal mass should undergo individual risk stratification including characterization of their tumor histology. At the present time, anatomical imaging techniques are unable to reliably distinguish between the various renal tumor subtypes...
January 11, 2018: Current Opinion in Urology
https://www.readbyqxmd.com/read/29319202/analysis-of-brain-spect-images-coregistered-with-mri-in-patients-with-epilepsy-comparison-of-three-methods
#11
Zaiyang Long, Dennis P Hanson, Brian P Mullan, Christopher H Hunt, David R Holmes, Benjamin H Brinkmann, Michael K O'Connor
BACKGROUND AND PURPOSE: SISCOM and STATISCOM were clinically proved to be effective for ictal/inter-ictal single-photon emission computed tomography (SPECT) analysis coregistered with magnetic resonance imaging (MRI) for seizure localization. Recently, a software package also became available for this analysis. This study aimed to investigate and compare the performance of these analysis methods for seizure localization. METHODS: A total of 378 patients who underwent 99m Tc-ethyl cysteinate dimer (ECD) SPECT scans were retrospectively reviewed and 28 remained after applying exclusion criteria...
January 10, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29319134/diagnostic-accuracy-of-planar-spect-and-spect-ct-parathyroid-scintigraphy-protocols-in-patients-with-hyperparathyroidism
#12
Yutapong Raruenrom, Daris Theerakulpisut, Nantaporn Wongsurawat, Charoonsak Somboonporn
BACKGROUND: Several parathyroid scintigraphy protocols have been used for preoperative localization of hyperfunctioning parathyroid glands in patients with hyperparathyroidism. The aim of this study is to compare the diagnostic accuracy of various parathyroid scintigraphy protocols. MATERIAL AND METHODS: A retrospective diagnostic accuracy study with histopathology as the reference standard was done. Five imaging protocols were investigated including planar dual tracer Tc-99m pertechnetate/Tc-99m sestamibi (DT), planar dual phase Tc-99m sestamibi (DP), and combined dual tracer dual phase (DTDP) protocols, as well as add-on single photon emission computed tomography (SPECT), and single photon emission computed tomography/computed tomography (SPECT/CT)...
January 10, 2018: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/29319132/evaluation-of-changes-in-perfusion-defect-and-left-ventricular-systolic-function-using-tc-99m-tetrofosmin-single-photon-emission-computed-tomography-over-3-month-period-in-patients-of-acute-myocardial-infarction-undergoing-primary-angioplasty
#13
Anil Kumar Avs, P G Kumar, Ajay Swami, Yiteedra Dinker
BACKGROUND: After a primary transluminal coronary angioplasty (PTCA) following AMI (acute myocardial infarction), the perfusion defect and LV (left ventricular) function recover/change over a period of time. The analysis immediately after the procedure may not be true depiction of the exact success of the procedure. There is varying and scanty information available on the natural course of changes in these parameters after a successful PTCA. We hypothesized that majority of change occurs at 3-4 month period...
January 10, 2018: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/29318965/current-status-of-molecular-imaging-in-infections
#14
Martina Sollini, Chiara Lauri, Roberto Boni, Elena Lazzeri, Paola Anna Erba, Alberto Signore
There is an increased need to find non-invasive tools for early diagnosis and follow-up of infections. Nuclear medicine techniques may be used to diagnose, localize and evaluate the severity and the extent of infections before the occurrence of anatomical abnormalities. This review focuses on different approaches based on radiolabelled cells, peptides and antibodies or [18F]FDG to image infective diseases in agreement with what is being jointly evaluated by the European Association of Nuclear Medicine (EANM)...
January 9, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29315366/long-term-prognostic-value-of-single-photon-emission-computed-tomography-myocardial-perfusion-imaging-after-primary-pci-for-stemi
#15
Jeff M Smit, Maaike P Hermans, Aukelien C Dimitriu-Leen, Alexander R van Rosendael, Petra Dibbets-Schneider, Lioe-Fee de Geus-Oei, Bart J Mertens, Martin J Schalij, Jeroen J Bax, Arthur J Scholte
Aims: The aim of this study was to determine the long-term prognostic value of infarct size and myocardial ischaemia on single-photon emission computed tomography myocardial perfusion imaging (SPECT MPI) after primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI). Methods and results: In total, 1092 STEMI patients who underwent primary PCI and SPECT MPI within 1-6 months were included (median follow-up time of 6...
January 5, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29314858/panitumumab-modified-with-metal-chelating-polymers-mcp-complexed-to-111in-and-177lu-an-egfr-targeted-theranostic-for-pancreatic-cancer
#16
Sadaf Aghevlian, Yijie Lu, Mitchell A Winnik, David W Hedley, Raymond M Reilly
A metal-chelating polymer (MCP) with a polyglutamide (PGlu) backbone presenting on average 13 DOTA (tetraazacyclododecane-1,4,7,10-tetraacetic acid) chelators for complexing 111In or 177Lu and 10 polyethylene glycol (PEG) chains to minimize liver and spleen uptake was conjugated to anti-epidermal growth factor receptor (EGFR) monoclonal antibody (mAb), panitumumab. Since panitumumab-MCP may be dual-labeled with 111In and 177Lu for SPECT, or radioimmunotherapy (RIT) exploiting the Auger electrons or β-particle emissions, respectively, we propose that panitumumab-MCP could be a useful theranostic agent EGFR-positive PnCa...
January 9, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29313360/diagnostic-bone-imaging-in-patients-with-prostate-cancer-patient-experience-and-acceptance-of-naf-pet-ct-choline-pet-ct-whole-body-mri-and-bone-spect-ct
#17
Eva Dyrberg, Emil L Larsen, Helle W Hendel, Henrik S Thomsen
Background Patient acceptance is an important factor when implementing imaging methods in clinical practice in line with availability, diagnostic accuracy, and cost-effectiveness. Purpose To investigate patient experience and acceptance regarding18F-sodium fluoride (NaF) positron emission tomography/computed tomography (PET/CT), 11 C-choline-PET/CT, whole-body magnetic resonance imaging (WB-MRI), and 99mTc-hydroxymethane diphosphonate (HDP) single photon emission/computed tomography (SPECT/CT). Material and Methods One hundred and forty-nine patients with prostate cancer filled in a questionnaire regarding their experience of the imaging procedures they had been undergoing as part of a diagnostic accuracy study...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29312775/case-report-improvement-of-cardiac-remodeling-with-shock-wave-therapy-of-a-patient-with-ischemic-cardiomyopathy
#18
Yingnan Bai, Xiaoyan Wang, Xin Deng, Hongyi Wu, Abdel Hamid Fathy, Yan Xi, Yunzeng Zou, Jie Cui, Junbo Ge
Percutaneous coronary intervention (PCI) and coronary-artery bypass grafting (CABG) are two major preferred reperfusion strategies to restore the ischemic-related artery patency, but PCI and CABG do not necessarily guarantee the recovery of post-procedure left ventricular (LV) dysfunction and release of symptoms. Moreover, there is no definitive effective way to enhance microcirculations. Theoretically, shock wave therapy (SWT) is an option. We report here a case of patient who received SWT. The patient's medical history was characterized by chest pain for 20 years, having received CABG 13 years ago...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29310821/sestamibi-spect-ct-versus-spect-only-for-preoperative-localization-in-primary-hyperparathyroidism-a-single-institution-8-year-analysis
#19
Kelly L McCoy, Anish G Ghodadra, Trilochan G Hiremath, Angela Albarano, Judith M Joyce, Linwah Yip, Sally E Carty, Ashok Muthukrishnan
BACKGROUND: Primary hyperparathyroidism is caused by single gland disease in 85% of cases and by multiglandular disease in 15%. Our aim was to discover if the addition of computed tomography acquisition/fusion on a hybrid scanner to traditional dual-phase single-photon emission tomography improves localization accuracy. METHODS: A prospective database was queried for the perioperative data of patients with sporadic primary hyperparathyroidism who had initial exploration from 2006-2014 with ≥6 month follow-up to define anatomy...
January 5, 2018: Surgery
https://www.readbyqxmd.com/read/29305726/evaluation-of-necrosis-avidity-and-potential-for-rapid-imaging-of-necrotic-myocardium-of-radioiodinated-hypocrellins
#20
Qiaomei Jin, Juanzhi Zhao, Meng Gao, Yuanbo Feng, Wei Liu, Zhiqi Yin, Tiannv Li, Shaoli Song, Yicheng Ni, Jian Zhang, Dejian Huang, Dongjian Zhang
PURPOSE: Rapid noninvasive delineation of necrotic myocardium in ischemic regions is very critical for risk stratification and clinical decision-making but still challenging. This study aimed to evaluate the necrosis avidity of radioiodinated hypocrellins and its potential for rapidly imaging necrotic myocardium. PROCEDURES: The aggregation constants of four natural hypocrellins were analyzed by UV/vis spectroscopy. Then, they were radiolabeled with iodine-131 by iodogen oxidation method...
January 5, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
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