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https://www.readbyqxmd.com/read/28532011/molecularly-imprinted-polymer-for-human-viral-pathogen-detection
#1
REVIEW
Aijaz Ahmad Malik, Chanin Nantasenamat, Theeraphon Piacham
Molecular imprinting has become an attractive synthetic approach for the fabrication of novel functional polymers with pre-designed molecular target selectivity. Such molecularly imprinted polymers (MIPs) have been applied in wide range of areas such as chemical and biological sensors, solid phase extraction and drug assays owing to their inherent robustness, reusability and reproducibility. Furthermore, MIPs can also be used as tools for studies concerning antibody/receptor binding site mimicry as well as being used as antibody substitutes for biomedical applications...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531995/scavenging-free-radicals-and-soaring-osteoinduction-by-extra-cellular-matrix-protein-based-nanocomposites-on-degenerative-bone-treatments
#2
Kavitha Kandiah, Navaneethan Duraisamy, Vinoth Amirthalingam, Balagurunathan Ramasamy
A number of materials are now available to alleviate the ever-growing bone disruption. However, these are inadequate and inappropriate for addressing issues associated natural process of aging and degeneration of bone due to diseases. This study advances the existing material and offers more privileged and synergistically active remedy for these conditions. Here, they are three different nano-composites prepared such as nano-TiO2 with chitosan (TC), nano-TiO2 with chondroitin 4-sulfate (TG), and nano-TiO2 with chitosan and chondroitin 4-sulfate (TCG), whereas nano-TiO2 act as a control...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531265/utility-of-nonhuman-primates-in-substance-use-disorders-research
#3
Matthew L Banks, Paul W Czoty, Sidney S Negus
Substance use disorders (i.e., drug addiction) constitute a global and insidious public health issue. Preclinical biomedical research has been invaluable in elucidating the environmental, biological, and pharmacological determinants of drug abuse and in the process of developing innovative pharmacological and behavioral treatment strategies. For more than 70 years, nonhuman primates have been utilized as research subjects in biomedical research related to drug addiction. There are already several excellent published reviews highlighting species differences in both pharmacodynamics and pharmacokinetics between rodents and nonhuman primates in preclinical substance abuse research...
May 20, 2017: ILAR Journal
https://www.readbyqxmd.com/read/28531116/photoreactions-of-endohedral-metallofullerene-with-siliranes-electronic-properties-of-carbosilylated-lu%C3%A2-n-ih-c80
#4
Masahiro Kako, Kazuya Minami, Taiki Kuroiwa, Shinpei Fukazawa, Yuki Arikawa, Michio Yamada, Yutaka Maeda, Qiao-Zhi Li, Shigeru Nagase, Takeshi Akasaka
Photochemical carbosilylation of Lu₃N@Ih-C80 was performed using siliranes (silacyclopropanes) to afford the corresponding [5,6]- and [6,6]-adducts. Electrochemical studies indicated that the redox potentials of the carbosilylated derivatives were shifted cathodically in comparison with those of the [5,6]-pyrrolidino adducts. The electronic effect of the silirane addends on Lu₃N@Ih-C80 was verified on the basis of density functional theory calculations.
May 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28530876/research-continuous-surveillance-of-sleep-apnea-patients-in-a-medical-surgical-unit
#5
Dana Supe, Leah Baron, Tom Decker, Kyle Parker, Jeanne Venella, Sarah Williams, Kari Beaton, John Zaleski
This report consists of two separate studies on the use of continuous capnography monitoring conducted in an effort to improve patient safety at Virtua Health System. The desire for improved patient safety is motivating continuous monitoring and improved surveillance in clinical areas not traditionally equipped for such monitoring. We explored the use of remote monitoring of capnography, using enterprise middleware, in patients recovering from surgery in a medical-surgical unit. Continuous monitoring traditionally has been used in higher-acuity settings, such as intensive care units...
May 2017: Biomedical Instrumentation & Technology
https://www.readbyqxmd.com/read/28530837/stereoselective-synthesis-of-the-equatorial-glycosides-of-legionaminic-acid
#6
Oskar Popik, Bibek Dhakal, David Crich
The synthesis of a legionaminic acid donor from N-acetyl neuraminic acid in fifteen steps and 19% overall yield is described. Activation of the adamantanyl thioglycoside in the donor with N-iodosuccinimide and trifluoromethanesulfonic anhydride in dichloromethane and acetonitrile at -78 degrees C in the presence of primary secondary and tertiary alcohols affords the corresponding glycosides in excellent yield and good to excellent equatorial selectivity. In particular coupling to the 4-OH of a suitably protected neuraminic acid derivative affords a disaccharide that closely resembles the glycosidic linikage in the polylegionaminic acid from the lipopolysaccharide of the Legionella pneumophila virulence factor...
May 22, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28530665/molecular-engineering-of-chiral-colloidal-liquid-crystals-using-dna-origami
#7
Mahsa Siavashpouri, Christian H Wachauf, Mark J Zakhary, Florian Praetorius, Hendrik Dietz, Zvonimir Dogic
Establishing precise control over the shape and the interactions of the microscopic building blocks is essential for design of macroscopic soft materials with novel structural, optical and mechanical properties. Here, we demonstrate robust assembly of DNA origami filaments into cholesteric liquid crystals, one-dimensional supramolecular twisted ribbons and two-dimensional colloidal membranes. The exquisite control afforded by the DNA origami technology establishes a quantitative relationship between the microscopic filament structure and the macroscopic cholesteric pitch...
May 22, 2017: Nature Materials
https://www.readbyqxmd.com/read/28530600/effects-of-electron-beam-irradiation-on-physicochemical-properties-of-corn-flour-and-improvement-of-the-gelatinization-inhibition
#8
Peiyu Xue, Yue Zhao, Chengrong Wen, Sheng Cheng, Songyi Lin
The properties and viscosity-reduction mechanism of corn flour irradiated by electron beam have not been understood properly. Here, we investigate the effects of electron beam irradiation (EBI) on the gelatinization and physicochemical properties of corn flour irradiated by 0-5.40kGy of electron beam. The total starch and crude fiber contents of corn flour decreased significantly (P<0.05) after EBI treatment, while the moisture and reducing sugar contents increased significantly (P<0.05). EBI caused perforations on the corn flour particle surfaces, and the irradiated parts of the particles would gradually peel off and afford smooth surfaces, spherical structures, and smaller sizes...
October 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28530399/pd-catalyzed-cross-coupling-of-terminal-alkynes-with-chromium-0-fischer-carbene-complexes
#9
Kang Wang, Fengjin Wu, Yan Zhang, Jianbo Wang
Alkyl chromium(0) carbene complexes typically undergo cycloadditions with alkynes to afford carbo- or heterocyclic compounds. In the presence of Pd catalyst, it is demonstrated that a traditional cycloaddition pathway is completely altered: instead of cycloaddition, oxidative cross-coupling reaction of alkyl chromium(0) carbene complexes with terminal alkynes occurs. The coupling reaction exhibits excellent functional group tolerance and good efficiency.
May 22, 2017: Organic Letters
https://www.readbyqxmd.com/read/28529863/ceramic-biocomposites-as-biodegradable-antibiotic-carriers-in-the-treatment-of-bone-infections
#10
REVIEW
Jamie Ferguson, Michael Diefenbeck, Martin McNally
Local release of antibiotic has advantages in the treatment of chronic osteomyelitis and infected fractures. The adequacy of surgical debridement is still key to successful clearance of infection but local antibiotic carriers seem to afford greater success rates by targeting the residual organisms present after debridement and delivering much higher local antibiotic concentrations compared with systemic antibiotics alone. Biodegradable ceramic carriers can be used to fill osseous defects, which reduces the dead space and provides the potential for subsequent repair of the osseous defect as they dissolve away...
2017: J Bone Jt Infect
https://www.readbyqxmd.com/read/28529711/we-can-shift-academic-culture-through-publishing-choices
#11
Corina J Logan
Researchers give papers for free (and often actually pay) to exploitative publishers who make millions off of our articles by locking them behind paywalls. This discriminates not only against the public (who are usually the ones that paid for the research in the first place), but also against the academics from institutions that cannot afford to pay for journal subscriptions and the 'scholarly poor'. I explain exploitative and ethical publishing practices, highlighting choices researchers can make right now to stop exploiting ourselves and discriminating against others...
2017: F1000Research
https://www.readbyqxmd.com/read/28529669/veggie-van-pilot-study-impact-of-a-mobile-produce-market-for-underserved-communities-on-fruit-and-vegetable-access-and-intake
#12
Lucia A Leone, Lindsey Haynes-Maslow, Alice S Ammerman
We conducted a pilot evaluation of the Veggie Van, a mobile produce market that brings weekly boxes of reduced-cost locally grown fruits and vegetables (F&V) to lower-income communities and offers cooking and nutrition education to customers. We conducted surveys just prior to starting Veggie Van at each of 3 sites and again at 2-3 months. F&V intake was measured with a 2-question item and a 10-item food frequency questionnaire (FFQ) in a subset of participants. At baseline, average servings/day of F&V was 4...
2017: Journal of Hunger & Environmental Nutrition
https://www.readbyqxmd.com/read/28529668/diastereoselective-radical-type-cyclopropanation-of-electron-deficient-alkenes-mediated-by-the-highly-active-cobalt-ii-tetramethyltetraaza-14-annulene-catalyst
#13
Andrei Chirila, Braja Gopal Das, Nanda D Paul, Bas de Bruin
A new protocol for the catalytic synthesis of cyclopropanes using electron-deficient alkenes is presented, which is catalysed by a series of affordable, easy to synthesise and highly active substituted cobalt(II) tetraaza[14]annulenes. These catalysts are compatible with the use of sodium tosylhydrazone salts as precursors to diazo compounds in one-pot catalytic transformations to afford the desired cyclopropanes in almost quantitative yields. The reaction takes advantage of the metalloradical character of the Co complexes to activate the diazo compounds...
April 21, 2017: ChemCatChem
https://www.readbyqxmd.com/read/28529529/disclosure-of-traditional-and-complementary-medicine-use-and-its-associated-factors-to-medical-doctor-in-primary-care-clinics-in-kuching-division-sarawak-malaysia
#14
Anak Kelak Johny, Whye Lian Cheah, Safii Razitasham
The decision by the patients to disclose traditional and complementary medicine (TCM) use to their doctor is an important area to be explored. This study aimed to determine the disclosure of TCM use and its associated factors to medical doctor among primary care clinic attendees in Kuching Division, Sarawak. It was a cross-sectional study using questionnaire, interviewer administered questionnaire. A total of 1130 patients were screened with 80.2% reporting using TCM. Logistic regression analysis revealed that being female (AOR = 3...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28529419/comparative-study-of-efficacy-and-safety-of-botulinum-toxin-a-injections-and-subcutaneous-curettage-in-the-treatment-of-axillary-hyperhidrosis
#15
Leelavathy Budamakuntla, Eswari Loganathan, Anju George, B N Revanth, V Sankeerth, Sacchidananda Aradhya Sarvjnamurthy
BACKGROUND: Primary focal axillary hyperhidrosis is a chronic distressing disorder affecting both the sexes. When the condition is refractory to conservative management, we should go for more promising therapies like intradermal botulinum toxin A (BtxA) injections in the axilla, and surgical therapies like subcutaneous curettage of sweat glands. AIMS AND OBJECTIVES: The aim of this study is to compare the efficacy, safety and duration of action of intradermal BtxA injections in one axilla and subcutaneous curettage of sweat glands in the other axilla of the same patient with axillary hyperhidrosis...
January 2017: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/28529215/innovative-program-delivery-and-determinants-of-frequent-visitation-to-a-mobile-medical-clinic-in-an-urban-setting
#16
Britton A Gibson, Jamie P Morano, Mary R Walton, Ruthanne Marcus, Alexei Zelenev, R Douglas Bruce, Frederick L Altice
The Community Health Care Van (CHCV) is a mobile medical clinic (MMC) that has served vulnerable populations in New Haven, Connecticut since 1993. This study explores utilization patterns to understand if certain populations frequently rely upon non-traditional health care within a representative MMC. Patient characteristics, services used, and visitation frequency were described and compared for 8,415 unique clients making 29,728 visits. Negative binomial regression was used to model the impact of specific indicators on visitation...
2017: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/28529213/effective-strategies-for-affordable-care-act-enrollment-in-immigrant-serving-safety-net-clinics-in-new-mexico
#17
Christina M Getrich, Jacqueline M García, Angélica Solares, Miria Kano
In the new Affordable Care Act (ACA) health care environment, safety-net institutions continue to serve as important sources of culturally appropriate care for different groups of immigrant patients. This article reports on a qualitative study examining the early ACA enrollment experiences of a range of health care providers (n = 29) in six immigrant-serving safety-net clinics in New Mexico. The six clinics configured their ACA enrollment strategies differently with regard to operations, staffing, and outreach...
2017: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/28529137/medicaid-participation-among-liver-transplant-candidates-after-the-affordable-care-act-medicaid-expansion
#18
Dmitry Tumin, Eliza W Beal, Khalid Mumtaz, Don Hayes, Joseph D Tobias, Timothy M Pawlik, W Kenneth Washburn, Sylvester M Black
BACKGROUND: The 2014 Medicaid expansion in participating states increased insurance coverage among people with chronic health conditions, but its implications for access to surgical care remain unclear. We investigated how Medicaid expansion influenced the insurance status of candidates for liver transplantation (LT) and transplant center payor mix. STUDY DESIGN: Data on LT candidates age 18-64 years in 2012-2013 (pre-expansion) and 2014-2015 (post-expansion) were obtained from the United Network for Organ Sharing registry...
May 18, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28529114/perceptions-of-healthy-eating-amongst-indian-adolescents-in-india-and-canada
#19
Natasha Correa, Divya Rajaraman, Sumathi Swaminathan, Mario Vaz, K G Jayachitra, Scott A Lear, Zubin Punthakee
INTRODUCTION: Dietary patterns have contributed to the rising prevalence of overweight and obesity among Indian adolescents. Yet there are limited studies on their perspectives on healthy eating. The purpose of this study was to understand perceptions and attitudes of Indian-origin adolescents in India and Canada that may contribute to healthy eating behaviour. METHODS: Qualitative data collection and analysis of 13 focus group discussions (FGD) was conducted among 34 boys and 39 girls (total number of participants: 73) of different weight and socioeconomic status (SES) in rural and urban India, and urban Canada aged 11-18 years...
May 18, 2017: Appetite
https://www.readbyqxmd.com/read/28529050/an-optical-alignment-system-improves-precision-of-soluble-aggregate-quantitation-by-sedimentation-velocity-analytical-ultracentrifugation
#20
Brandon L Doyle, Ivan L Budyak, Adam P Rauk, William F Weiss
Appropriate characterization of soluble aggregates is an important aspect of biologics development and manufacturing, and sedimentation velocity analytical ultracentrifugation (SV-AUC) is often used an orthogonal technique to size-exclusion chromatography (SEC) for this purpose. Precise quantification of low levels of soluble aggregates by SV-AUC can be adversely impacted by improper cell alignment. This report describes the development of an optical system capable of quantifying cell alignment that affords a substantial improvement compared to historical approaches...
May 18, 2017: Analytical Biochemistry
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