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https://www.readbyqxmd.com/read/29161664/sandwich-type-biosensor-for-the-detection-of-%C3%AE-2-3-sialylated-glycans-based-on-fullerene-palladium-platinum-alloy-and-4-mercaptophenylboronic-acid-nanoparticle-hybrids-coupled-with-au-methylene-blue-mal-signal-amplification
#1
Qiqi Yuan, Junlin He, Yazhen Niu, Jun Chen, Yilin Zhao, Yuchan Zhang, Chao Yu
α2,3-sialylated glycans (α2,3-sial-Gs) are one of the significant tumour biomarkers for the early diagnosis of cancer. In this work, a neoteric sandwich-type biosensor was developed for detecting α2,3-sial-Gs using 4-mercaptophenylboronic acid (4-MPBA) to construct a novel molecular recognition system by the coordination of a boron atom of 4-MPBA to the amide group of Neu5Ac in the α2,3-sial-Gs structure. Amino-functionalized fullerene coupled with palladium-platinum bimetallic alloy nanocrystals (n-C60-PdPt) was synthesized to modify the surface of a glassy carbon electrode (GCE) because the n-C60 nanomaterial affords a large surface area for the on-site reduction of bimetallic alloy nanoparticles and an excellent capacity for electron transfer...
November 18, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29161268/nucleic-acid-purification-from-plants-animals-and-microbes-in-under-30-seconds
#2
Yiping Zou, Michael Glenn Mason, Yuling Wang, Eugene Wee, Conny Turni, Patrick J Blackall, Matt Trau, Jose Ramon Botella
Nucleic acid amplification is a powerful molecular biology tool, although its use outside the modern laboratory environment is limited due to the relatively cumbersome methods required to extract nucleic acids from biological samples. To address this issue, we investigated a variety of materials for their suitability for nucleic acid capture and purification. We report here that untreated cellulose-based paper can rapidly capture nucleic acids within seconds and retain them during a single washing step, while contaminants present in complex biological samples are quickly removed...
November 2017: PLoS Biology
https://www.readbyqxmd.com/read/29161187/network-mapping-with-gimme
#3
Adriene M Beltz, Kathleen M Gates
Network science is booming! While the insights and images afforded by network mapping techniques are compelling, implementing the techniques is often daunting to researchers. Thus, the aim of this tutorial is to facilitate implementation in the context of GIMME, or group iterative multiple model estimation. GIMME is an automated network analysis approach for intensive longitudinal data. It creates person-specific networks that explain how variables are related in a system. The relations can signify current or future prediction that is common across people or applicable only to an individual...
November 2017: Multivariate Behavioral Research
https://www.readbyqxmd.com/read/29161062/exposure-to-marijuana-marketing-after-legalization-of-retail-sales-oregonians-experiences-2015-2016
#4
Steven C Fiala, Julia A Dilley, Caislin L Firth, Julie E Maher
OBJECTIVES: To assess exposure to marijuana advertising in Oregon after the start of retail marijuana sales in October 2015. METHODS: We conducted a repeated cross-sectional online survey of 4001 Oregon adults aged 18 years and older in November 2015 and April-May 2016. We assessed subgroup differences by using the Pearson χ(2) test. RESULTS: More than half of adults (54.8%) statewide reported seeing marijuana advertising in the past month...
November 21, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/29161050/fecl3-mediated-domino-reaction-of-benzoxazinones-with-aroylmethylidene-malonates-synthesis-to-functionalized-pyrrolobenzoxazines
#5
Shweta Bisht, Rama Krishna Peddinti
An efficient domino approach for the synthesis of pyrrolobenzoxazine derivatives is described. The FeCl3-promoted domino reaction between aroylmethylidene malonates and benzoxazinones has been successfully established to afford the title compounds in good to excellent yield under mild reaction conditions. The domino protocol provides a concise and straightforward access to highly substituted pyrrolobenzoxazines with high efficiency and excellent functional group tolerance.
November 21, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29161038/a-ag-catalyzed-tandem-three-component-reaction-towards-the-synthesis-of-multisubstituted-imidazoles
#6
Changcheng Wang, Jialin Lai, Cantao Chen, Xuechen Li, Hua Cao
A facile one pot, Ag-catalyzed tandem three-component reaction of amidines, ynals, and carboxylic acids or amines to form imidazole skeletons has been developed. This multicomponent reaction has been applied to various substituted amidines and carboxylic acids substrates, affording the products in good yields. The strategy could provide an efficient and green molecular fragment assembly to access imidazoles.
November 21, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29161025/e-h-e-b-si-c-bond-activation-by-tuning-structural-and-electronic-properties-of-phosphenium-cations
#7
Nemanja Đorđević, Rakesh Ganguly, Milena Petković, Dragoslav Vidović
In this work, strategic enhancement of electrophilicity of phosphenium cations for the purpose of small-molecule activation was described. Our synthetic methodology for generation of novel two-coordinate phosphorus(III)-based compounds [{C6H4(MeN)2C}2C·PR](2+) ([2a](2+), R = N(i)Pr2; [2b](2+), R = Ph) was based on the exceptional electron-donating properties of the carbodicarbene ligand (CDC). The effects of P-centered substituent exchange and increase in the overall positive charge on small substrate activation were comparatively determined by incorporating the bis(amino)phosphenium ion [((i)Pr2N)2P](+) ([1](+)) in this study...
November 21, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29160702/heterometallic-heptanuclear-cu5ln2-ln-tb-dy-and-ho-single-molecule-magnets-organized-in-one-dimensional-coordination-polymeric-network
#8
Atanu Dey, Sourav Das, Subrata Kundu, Abhishake Mondal, Mathieu Rouzières, Corine Mathonière, Rodolphe Clérac, Ramakirushnan Suriya Narayanan, Vadapalli Chandrasekhar
The reaction of a multisite coordination ligand, LH3, with Cu(II) salts and Ln(NO3)3·nH2O in a 1:2:1 stoichiometric ratio in the presence of triethylamine was found to afford a series of one-dimensional heterometallic [{Cu5Ln2(L)2(μ3-OH)4(ClO4)(NO3)3(OH2)5}(ClO4)2(H2O)x]∞ [Ln = Tb(1), Dy(2) and Ho(3), x = 4.25, 5.5, and 5 for 1-3, respectively] coordination polymers. Complexes 1-3 have been characterized by single crystal X-ray crystallography. The detailed study of the magnetic properties has also been performed and compared with the parent [Cu5Ln2] molecular analogues...
November 21, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29160463/access-to-medicines-by-patients-of-the-primary-health-care-in-the-brazilian-unified-health-system
#9
Juliana Álvares, Augusto Afonso Guerra, Vânia Eloisa de Araújo, Alessandra Maciel Almeida, Carolina Zampirolli Dias, Bruna de Oliveira Ascef, Ediná Alves Costa, Ione Aquemi Guibu, Orlando Mario Soeiro, Silvana Nair Leite, Margô Gomes de Oliveira Karnikowski, Karen Sarmento Costa, Francisco de Assis Acurcio
OBJECTIVE: To evaluate the access to medicines in primary health care of the Brazilian Unified Health System (SUS), from the patients' perspective. METHODS: This is a cross-sectional study that used data from the Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos - Services, 2015 (PNAUM - National Survey on Access, Use and Promotion of Rational Use of Medicines), conducted by interviews with 8,591 patients in cities of the five regions of Brazil...
November 13, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29159919/smart-phone-accessibility-and-mhealth-use-in-a-limited-resource-setting
#10
Shelby L Garner, Tanya Sudia, Spurgeon Rachaprolu
AIM: To determine smartphone access and use including future opportunities for mHealth and potential ethical implications among health care professionals practicing at a health care facility in Bengaluru, India. BACKGROUND: The evolution of smart phones can provide convenient, portable, and rapid access to resources for health care professionals. While mobile phone accessibility has improved in recent years in many low and middle-income countries, the use of smart phones to address health priorities remains limited in some limited resource settings...
November 20, 2017: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/29159912/nickel-0-catalyzed-hydroarylation-of-styrenes-and-1-3-dienes-with-organoborons
#11
Qi-Lin Zhou, Li-Jun Xiao, Lei Cheng, Wei-Min Feng, Mao-Lin Li, Jian-Hua Xie
The Ni-catalyzed hydroarylation of styrenes and 1,3-dienes with organoborons has been developed. The reaction offers a highly selective approach to the diarylalkanes and allylarenes under redox-neutral condition. In this hydroarylation reaction, a new strategy that uses easily available proton of methanol to generate active catalyst species Ni-H was developed. The Ni-catalyzed hydroarylation, combining with a Ir-catalyzed C-H borylation, affords a very efficient and straightforward access to retinoic acid receptor agonist...
November 20, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29159523/quantitating-whole-lesion-tumor-biology-in-rectal-cancer-mri-taking-a-lesson-from-fdg-pet-tumor-metrics
#12
Marc J Gollub, Andreas M Hotker, Kaitlin M Woo, Yousef Mazaheri, Mithat Gonen
PURPOSE: To determine the value of novel whole tumor metrics in DWI-MRI and DCE-MRI of rectal cancer treatment assessment. MATERIALS AND METHODS: This retrospective study included 24 uniformly treated patients with rectal adenocarcinoma who underwent MRI including diffusion-weighted (DW) and dynamic contrast-enhanced (DCE) sequences, before and after chemoradiotherapy. Two experienced readers independently measured tumor volume and apparent diffusion coefficient (ADC) on DWI-MRI and tumor volume and transfer constant K (trans) on DCE-MRI...
November 20, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29158890/oxidation-of-pyrrole-by-dehaloperoxidase-hemoglobin-chemoenzymatic-synthesis-of-pyrrolin-2-ones
#13
Nikolette L McCombs, Tatyana Smirnova, Reza A Ghiladi
The use of oxidoreductases as biocatalysts in the syntheses of functionalized, monomeric pyrroles has been a challenge owing to, among a number of factors, undesired polypyrrole formation. Here, we have investigated the ability of dehaloperoxidase (DHP), the coelomic hemoglobin from the terebellid polychaete Amphitrite ornata, to catalyze the H2O2-dependent oxidation of pyrroles as a new class of substrate for this enzyme. Substrate oxidation was observed for all compounds employed (pyrrole, N-methylpyrrole, 2-methylpyrrole, 3-methylpyrrole and 2,5-dimethylpyrrole) under both aerobic and anaerobic conditions...
2017: Catalysis Science & Technology
https://www.readbyqxmd.com/read/29158714/synthesis-and-anticancer-activity-of-new-quinazoline-derivatives
#14
Hatem A Abuelizz, Mohamed Marzouk, Hazem Ghabbour, Rashad Al-Salahi
In this study, a new series of quinazoline derivatives (3-26) was synthesized and characterized via physicochemical and spectral means. Treatment of 2-amino-5-methylbenzoic acid with butyl isothiocyanate resulted in the new 2-thioxoquinazolin-4-one (3). Alkylation and hydrazinolysis of the inherent thioxo group in (1-3) afforded the corresponding thioethers (4-23) and hydrazine derivatives (24 and 25), then 24 was further transformed into tricyclic derivative 26 via cyclocondensation reaction. Compounds 1 and 2, which were previously synthesized, were found to exhibit anticancer activity...
November 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29158655/bikeshare-use-in-urban-communities-individual-and-neighborhood-factors
#15
Gabriela R Oates, Bryant W Hamby, Sejong Bae, Maria C Norena, H Olivia Hart, Mona N Fouad
Objective: Bicycling is an affordable way to increase access to employment, schooling, and services and an effective measure against obesity. Bikeshare programs can make bicycling accessible to diverse populations, but little evidence exists on their adoption in low-resource neighborhoods. Our study examined factors associated with bikeshare use in a metropolitan area in the southern United States. Methods: We performed a retrospective cross-sectional analysis of a database of clients (N=815) who rented a bicycle from Zyp Bikeshare in Birmingham, Alabama between October 2015 and November 2016...
2017: Ethnicity & Disease
https://www.readbyqxmd.com/read/29157817/cardioprotective-action-of-the-aqueous-extract-of-terminalia-arjuna-bark-against-toxicity-induced-by-doxorubicin
#16
Sarah Bishop, Shi J Liu
BACKGROUND: The aqueous extract of Terminalia arjuna (TA) bark (TAAqE) has been shown to have a direct inotropic effect on ventricular myocytes. Active constituents of TAAqE contain various flavonoids and proanthocyanidins, some of which are known to have antioxidant activities. Whether TAAqE affords a cardioprotective action against oxidative stress (OS) remains unclear. PURPOSE: Increased OS is one of the major mechanisms underlying cardiotoxicity induced by doxorubicin (DOX), a commonly-used anticancer agent...
December 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29157569/a-regional-consortium-for-doctor-of-nursing-practice-education-integrating-improvement-science-into-the-curriculum
#17
Shea Polancich, Linda Roussel, Barbara Ann Graves, Pamela V O'Neal
The DNP curriculum prepares the graduate for evidence informed improvement translation through coursework integrating improvement, safety, and translation sciences. Innovative leadership skills are necessary to lead inter-professional unit-based and health system opportunities. Equipping the DNP with the necessary skills and competencies to accomplish any type of improvement translation requires exposure to the tools and techniques of these sciences with an emphasis in didactic content. With a foundational knowledge of the principles for improvement, translation and application will follow...
November 2017: Journal of Professional Nursing: Official Journal of the American Association of Colleges of Nursing
https://www.readbyqxmd.com/read/29157566/is-health-care-payment-reform-impacting-nurses-work-settings-roles-and-education-preparation
#18
Mary Val Palumbo, Betty Rambur, Vicki Hart
This study explores nurses' work settings and educational preparation in the five years before passage of the Affordable Care Act (ACA) and five years after ACA passage, with the aim of identifying areas for nurse educators' attention. The study setting was one small state undergoing rapid transition away from fee-for-service service and thus provided the ideal laboratory to assess the impact of health reform on the nursing workforce. A secondary analysis of data gathered during relicensure compared the nursing workforce at an interval of one decade, with surveys in 2005 (n=4075; 65% response rate) and in 2015 (n=6723; 97% response rate)...
November 2017: Journal of Professional Nursing: Official Journal of the American Association of Colleges of Nursing
https://www.readbyqxmd.com/read/29157211/alkaline-peptone-water-enrichment-with-a-dipstick-test-to-quickly-detect-and-monitor-cholera-outbreaks
#19
Godfrey Bwire, Christopher Garimoi Orach, Dauda Abdallah, Amanda Kay Debes, Atek Kagirita, Malathi Ram, David A Sack
BACKGROUND: Detection, confirmation and monitoring of cholera outbreaks in many developing countries including Uganda is a big challenge due to lack of the required resources and the time the test takes. Culture method which takes 24-48 h to get the feedback and requires highly skilled laboratory staff plus other complex resources is the standard test. This study evaluated the new cholera rapid detection method that relies on Crystal VC dipsticks after enrichment with alkaline peptone water (APW) against the culture method for monitoring the progress of cholera outbreaks in rural setting...
November 21, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29156982/cytotoxic-ring-a-seco-triterpenoids-from-the-stem-bark-of-dysoxylum-lukii
#20
Rui Huang, Ying Zhao, Ying Wang, Lei Zhou, Yu-Feng Chen, Jin-Feng Wang
A chemical investigation of the 70% ethanol extract from the stem bark of Dysoxylum lukii afforded three new ring A-seco triterpenoids, dysoxylukiines A-C (1-3). Their structures were elucidated on the basis of extensive 1D and 2D NMR (COSY, HMQC, HMBC, and NOESY) analyses. The isolated compounds were evaluated in vitro for cytotoxic properties. Consequently, compound 3 exhibited modest cytotoxic activities against four osteosarcoma cell lines (SOSP-9607, MG-63, Saos-2, and M663) with IC50 values less than 10 μM...
November 21, 2017: Journal of Asian Natural Products Research
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