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https://www.readbyqxmd.com/read/29351413/mitochondrial-content-is-preserved-throughout-disease-progression-in-the-mdx-mouse-model-of-duchenne-muscular-dystrophy-regardless-of-taurine-supplementation
#1
Robert G Barker, Victoria L Wyckelsma, Hongyang Xu, Robyn M Murphy
Mitochondrial dysfunction is a pathological feature of Duchenne muscular Dystrophy (DMD), a debilitating and fatal neuromuscular disorder characterised by progressive muscle wasting and weakness. Mitochondria are a source of cellular ATP and involved in Ca2+ regulation and apoptotic signalling. Ameliorating aberrant mitochondrial function has therapeutic potential for reducing DMD disease severity. The dystrophic mdx mouse exhibits peak muscle damage at 21-28d which stabilises after 8 weeks. The amino acid taurine is implicated in mitochondrial health and function, with endogenous concentrations low when measured during the cycle of peak muscle damage in mdx mice...
December 20, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29351374/fast-dynamic-docking-guided-by-adaptive-electrostatic-bias-the-md-binding-approach
#2
Andrea Spitaleri, Sergio Decherchi, Andrea Cavalli, Walter Rocchia
Engineering chemical entities to modify how pharmaceutical targets function, as it is done in drug design, requires a good understanding of molecular recognition and binding. In this context, the limitations of statically describing bimolecular recognition, as done in docking/scoring, call for insightful and efficient dynamical investigations. On the experimental side, the characterization of dynamical binding processes is still in its infancy. Thus, computer simulations, particularly molecular dynamics (MD), are compelled to play a prominent role, allowing a deeper comprehension of the binding process and its causes and thus a more informed compound selection, making more significant the computational contribution to drug discovery1...
January 19, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29350744/preventing-mesh-pore-collapse-by-designing-mesh-pores-with-auxetic-geometries-a-comprehensive-evaluation-via-computational-modeling
#3
Katrina Knight, Pamela Moalli, Steven D Abramowitch
Pelvic organ prolapse meshes are exposed to predominately tensile loading conditions in vivo that can lead to pore collapse by 70-90%, decreasing overall porosity, and providing a plausible mechanism for the contraction/shrinkage of mesh observed following implantation. To prevent pore collapse, we proposed to design synthetic meshes with a macrostructure that results in auxetic behavior, the pores expand laterally, instead of contracting when loaded. Such behavior can be achieved with a range of auxetic structures/geometries...
January 19, 2018: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29350733/a-catalyst-free-intermolecular-trans-iodoalkylation-of-alkynes
#4
Jie-Jie Liu, Hong-Yan Huang, Liang Cheng, Qi Liu, Dong Wang, Li Liu
We report the first catalyst-free and trans-selective iodoalkylation reaction of alkynes with a series of α-carbonyl compounds. This unprecedented three-component iodoalkylation reaction is enabled by using (iodoethynyl)trimethylsilane as a radical initiator and iodide source. The 1,2-difunctionalization affords alkenyl iodides, which are versatile building blocks for the construction of tri-substituted alkene derivatives.
January 19, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29350298/contribution-of-m%C3%A3-ssbauer-spectroscopy-to-the-investigation-of-fe-s-biogenesis
#5
REVIEW
Ricardo Garcia-Serres, Martin Clémancey, Jean-Marc Latour, Geneviève Blondin
Fe/S cluster biogenesis involves a complex machinery comprising several mitochondrial and cytosolic proteins. Fe/S cluster biosynthesis is closely intertwined with iron trafficking in the cell. Defects in Fe/S cluster elaboration result in severe diseases such as Friedreich ataxia. Deciphering this machinery is a challenge for the scientific community. Because iron is a key player, 57Fe-Mössbauer spectroscopy is especially appropriate for the characterization of Fe species and monitoring the iron distribution...
January 19, 2018: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/29350262/vagal-nerve-stimulation-for-medically-refractory-epilepsy-in-angelman-syndrome-a-series-of-three-cases
#6
REVIEW
Krystal L Tomei, Christine Y Mau, Michael Ghali, Jayoung Pak, Ira M Goldstein
BACKGROUND: We describe three children with Angelman syndrome and medically refractory epilepsy. METHODS: Case series of three pediatric patients with Angelman syndrome and medically refractory epilepsy. All three patients failed medical treatment and were recommended for vagal nerve stimulator (VNS) implantation. RESULTS: Following VNS implantation, all three patients experienced reduction in seizure frequency greater than that afforded by medication alone...
January 19, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29350076/health-care-public-sector-share-and-the-u-s-life-expectancy-lag-a-country-level-longitudinal-study
#7
Megan M Reynolds
Growing research on the political economy of health has begun to emphasize sociopolitical influences on cross-national differences in population health above and beyond economic growth. While this research investigates the impact of overall public health spending as a share of GDP ("health care effort"), it has for the most part overlooked the distribution of health care spending across the public and private spheres ("public sector share"). I evaluate the relative contributions of health care effort, public sector share, and GDP to the large and growing disadvantage in U...
January 1, 2018: International Journal of Health Services: Planning, Administration, Evaluation
https://www.readbyqxmd.com/read/29349863/experimental-observation-of-thermally-excited-triplet-states-of-heavier-group-15-element-centered-diradical-dianions
#8
Yong Fang, Li Zhang, Cheng Cheng, Yue Zhao, Manabu Abe, Gengwen Tan, Xinping Wang
One-electron reductions of Mes*As=Fl* (1; Fl* = 2,7-di-tert-butylfluorenylidene, Mes* = 2,4,6-tBu3C6H2) and diarsaalkenes [1,2-b]-IF(=AsMes*)2 (2; IF = indenofluorene) with potassium led to the isolation of the arsenic-centered radical anion salts 1K and 2K, respectively. The diradical dianion salts 2K2 and 3K2 were afforded by the reduction of 2 and 2,8-tBu2-[2,1-b]-IF(=AsMes*)2 (3) with an excess amount of KC8. The radicals have been investigated by single-crystal X-ray crystallography, EPR and UV-Vis absorption spectroscopy, along with theoretical calculations...
January 18, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29349853/piezotronic-tuning-of-potential-barriers-in-zno-bicrystals
#9
Peter Keil, Maximilian Trapp, Nikola Novak, Till Frömling, Hans-Joachim Kleebe, Jürgen Rödel
Coupling of magnetic, ferroelectric, or piezoelectric properties with charge transport at oxide interfaces provides the option to revolutionize classical electronics. Here, the modulation of electrostatic potential barriers at tailored ZnO bicrystal interfaces by stress-induced piezoelectric polarization is reported. Specimen design by epitaxial solid-state transformation allows for both optimal polarization vector alignment and tailoring of defect states at a semiconductor-semiconductor interface. Both quantities are probed by transmission electron microscopy...
January 19, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29349836/evaluation-of-a-west-australian-residential-mental-health-respite-service
#10
Sue Gillieatt, Robyn Martin, Kate P Dorozenko, Adrian Munro
Family members continue to be the predominant providers of support, care and accommodation for loved ones with mental health issues, and empirical studies suggest that accessing mental health respite can be helpful for both carers and consumers. However, the availability of, and access to, this respite in Australia is far from optimal. Major issues have also been identified such as low utilisation, the inappropriate and inflexible nature of services and the inability of services to respond to situations where multiple needs exist...
January 18, 2018: Health & Social Care in the Community
https://www.readbyqxmd.com/read/29349825/synthesis-of-single-and-double-dibenzohelicenes-via-rhodium-catalyzed-intramolecular-2-2-2-and-2-1-2-1-cycloadditions
#11
Ryota Yamano, Yu Shibata, Ken Tanaka
Dibenzo[7]helicenes were synthesized with up to 99% ee via the rhodium(I)/binap complex-catalyzed enantioselective intramolecular [2+2+2] cycloaddition of 2-phenylnaphthalene-linked tryines. Additionally, [2+1+2+1] cycloaddition products, twisted anthracenes, were also synthesized by using difluorphos as a ligand. Although this compound is not configurationally stable at elevated temperature, the Scholl reaction of which afforded a configurationally stable double dibenzo[6]helicene. The thus obtained dibenzo[7]helicene exhibited good circularly polarized luminescence property and the double dibenzo[6]helicene exhibited high fluorescence quantum yield...
January 18, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29349754/strategies-to-maintain-fertility-in-young-breast-cancer-patients
#12
Elizabeth S Constance, Molly B Moravek, Jacqueline S Jeruss
Breast cancer is the most frequently occurring cancer in women of reproductive age. Treatments for breast cancer may eliminate or diminish fertility, making discussions about fertility preservation essential prior to initiation of gonadotoxic therapies. Additionally, even in patients who do not require chemotherapy, the use of adjuvant endocrine therapy will often push patients out of the reproductive window before treatment is completed. The only established methods for fertility preservation are oocyte or embryo cryopreservation, but experimental methods, such as ovarian suppression with GnRH agonists and ovarian tissue cryopreservation, show great promise...
2018: Cancer Treatment and Research
https://www.readbyqxmd.com/read/29349743/chemically-and-size-resolved-particulate-matter-dry-deposition-on-stone-and-surrogate-surfaces-inside-and-outside-the-low-emission-zone-of-milan-application-of-a-newly-developed-deposition-box
#13
Luca Ferrero, Marco Casati, Lara Nobili, Luca D'Angelo, Grazia Rovelli, Giorgia Sangiorgi, Cristiana Rizzi, Maria Grazia Perrone, Antonio Sansonetti, Claudia Conti, Ezio Bolzacchini, Elena Bernardi, Ivano Vassura
The collection of atmospheric particles on not-filtering substrates via dry deposition, and the subsequent study of the particle-induced material decay, is trivial due to the high number of variables simultaneously acting on the investigated surface. This work reports seasonally resolved data of chemical composition and size distribution of particulate matter deposed on stone and surrogate surfaces obtained using a new method, especially developed at this purpose. A "Deposition Box" was designed allowing the particulate matter dry deposition to occur selectively removing, at the same time, variables that can mask the effect of airborne particles on material decay...
January 19, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29349290/a-novel-neuroprotective-mechanism-for-lithium-that-prevents-association-of-the-p75ntr-sortilin-receptor-complex-and-attenuates-prongf-induced-neuronal-death-in-vitro-and-in-vivo
#14
Shayri G Greenwood, Laura Montroull, Marta Volosin, Helen E Scharfman, Kenneth K Teng, Matthew Light, Risa Torkin, Fredrick Maxfield, Barbara L Hempstead, Wilma J Friedman
Neurotrophins play critical roles in the survival, maintenance and death of neurons. In particular, proneurotrophins have been shown to mediate cell death following brain injury induced by status epilepticus (SE) in rats. Previous studies have shown that pilocarpine-induced seizures lead to increased levels of proNGF, which binds to the p75NTR-sortilin receptor complex to elicit apoptosis. A screen to identify compounds that block proNGF binding and uptake into cells expressing p75 and sortilin identified lithium citrate as a potential inhibitor of proNGF and p75NTR-mediated cell death...
January 2018: ENeuro
https://www.readbyqxmd.com/read/29349015/patellar-tendon-repair-with-ipsilateral-semitendinosus-autograft-augmentation
#15
Jarret M Woodmass, Joshua D Johnson, Isabella T Wu, Aaron J Krych, Michael J Stuart
Patellar tendon ruptures are rare but potentially devastating injuries. Acute repair after patellar tendon rupture affords the best opportunity for tension-free restoration of the extensor mechanism. Biological augmentation of primary repair is believed to decrease strain across the repair site and reduce the risk of rerupture. We present a technique for primary patellar tendon repair with bidirectional fixation using transosseous tunnels, suture anchor fixation, and ipsilateral hamstring autograft augmentation in a distal patellar pole socket...
December 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29348998/meniscal-repair-with-fibrin-clot-augmentation
#16
Jorge Chahla, Nicholas I Kennedy, Andrew G Geeslin, Gilbert Moatshe, Mark E Cinque, Nicholas N DePhillipo, Robert F LaPrade
Meniscal injuries and meniscal loss are associated with changes in knee kinematics and loading, ultimately leading to poor functional outcomes and increased risk of progression to osteoarthritis. Biomechanical studies have shown restored knee function, and clinical studies have reported improved outcomes and decreased risk of osteoarthritis after meniscal repair. This has led orthopaedic surgeons to try and save the meniscus by repair whenever possible, as shown by increasing incidence of meniscal repair surgeries...
December 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29348914/exploring-health-insurance-services-in-sudan-from-the-perspectives-of-insurers
#17
Anas Mustafa Ahmed Salim, Fatima Hashim Mahmoud Hamed
Background: It has been 20 years since the introduction of health insurance in Sudan. This study was the first one that explored health insurance services in Sudan from the perspectives of the insurers. Methods: This was a qualitative, exploratory, interview study. The sampling frame was the list of Social Health Insurance and Private Health Insurance institutions in Sudan. Participants were selected from the four Social Health Insurance institutions and from five Private Health Insurance companies...
2018: SAGE Open Medicine
https://www.readbyqxmd.com/read/29348552/tpglda-novel-prediction-of-associations-between-lncrnas-and-diseases-via-lncrna-disease-gene-tripartite-graph
#18
Liang Ding, Minghui Wang, Dongdong Sun, Ao Li
Accumulating evidences have indicated that lncRNAs play an important role in various human complex diseases. However, known disease-related lncRNAs are still comparatively small in number, and experimental identification is time-consuming and labor-intensive. Therefore, developing a useful computational method for inferring potential associations between lncRNAs and diseases has become a hot topic, which can significantly help people to explore complex human diseases at the molecular level and effectively advance the quality of disease diagnostics, therapy, prognosis and prevention...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348070/rational-approach-to-highly-potent-and-selective-apoptosis-signal-regulating-kinase-1-ask1-inhibitors
#19
Frank Lovering, Paul Morgan, Christophe Allais, Ann Aulabaugh, Joanne Brodfuehrer, Jeanne Chang, Jotham Coe, WeiDong Ding, Heather Dowty, Margaret Fleming, Richard Frisbie, Julia Guzova, David Hepworth, Jayasankar Jasti, Steve Kortum, Ravi Kurumbail, Shashi Mohan, Nikolaos Papaioannou, Joseph W Strohbach, Fabien Vincent, Katherine Lee, Christoph W Zapf
Many diseases are believed to be driven by pathological levels of reactive oxygen species (ROS) and oxidative stress has long been recognized as a driver for inflammatory disorders. Apoptosis signal-regulating kinase 1 (ASK1) has been reported to be activated by intracellular ROS and its inhibition leads to a down regulation of p38-and JNK-dependent signaling. Consequently, ASK1 inhibitors may have the potential to treat clinically important inflammatory pathologies including renal, pulmonary and liver diseases...
December 15, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29348056/achieving-local-and-global-shared-realities-distance-guides-alignment-to-specific-or-general-social-influences
#20
REVIEW
Alison Ledgerwood, Y Andre Wang
Humans routinely navigate a multitude of potential social influences, ranging from specific individual's opinions to general social norms and group values. Whereas specific social influences afford opportunities to achieve shared inner states with particular individuals, general social influences afford opportunities to achieve shared inner states with broader groups. We review recent theory and evidence examining how people tune into different kinds of social influence in the service of shared reality. We argue that the distance of an attitude object (e...
January 8, 2018: Current Opinion in Psychology
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