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https://www.readbyqxmd.com/read/28749321/design-and-implementation-of-an-affordable-public-sector-electronic-medical-record-in-rural-nepal
#1
Anant Raut, Chase Yarbrough, Vivek Singh, Bikash Gauchan, David Citrin, Varun Verma, Jessica Hawley, Dan Schwarz, Alex Harsha Bangura, Biplav Shrestha, Ryan Schwarz, Mukesh Adhikari, Duncan Maru
INTRODUCTION: Globally, electronic medical records are central to the infrastructure of modern healthcare systems. Yet the vast majority of electronic medical records have been designed for resource-rich environments and are not feasible in settings of poverty. Here we describe the design and implementation of an electronic medical record at a public sector district hospital in rural Nepal, and its subsequent expansion to an additional public sector facility.DevelopmentThe electronic medical record was designed to solve for the following elements of public sector healthcare delivery: 1) integration of the systems across inpatient, surgical, outpatient, emergency, laboratory, radiology, and pharmacy sites of care; 2) effective data extraction for impact evaluation and government regulation; 3) optimization for longitudinal care provision and patient tracking; and 4) effectiveness for quality improvement initiatives...
June 23, 2017: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/28749267/comparison-of-isoflurane-and-sevoflurane-for-short-term-anesthesia-in-meerkats-suricata-suricatta-are-there-benefits-that-outweigh-costs
#2
Taina B Strike, Jon Bielby, Yedra Feltrer, Hatim I K Alibhai, Matthew Rendle, David M Neilson
Meerkats ( Suricata suricatta ) are routinely anesthetized with isoflurane in zoo and field settings. Twenty healthy adult meerkats of mixed age and sex held in the Zoological Society of London's collection were anesthetized with 4% isoflurane by face mask for routine health examinations. The procedure was repeated 5 mo later in the same group of animals utilizing sevoflurane at 5% for induction, and again 3 mo later with sevoflurane at 6.5% for induction to approximate equipotency with isoflurane. The speed and quality of induction and recovery were compared between the two volatile anesthetic agents...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28749064/the-stepwise-reaction-of-rhodium-and-iridium-complexes-of-formula-mcl2-%C3%AE%C2%BA4c-n-n-p-l-with-silver-cations-a-case-of-trans-influence-and-chiral-self-recognition
#3
Daniel Carmona, María Carmona, Leyre Tejedor, Ricardo Rodríguez, Vincenzo Passarelli, Fernando José Lahoz, Pilar García-Orduña
Acetonitrile suspensions of the dichlorido complexes [MCl2(κ4C,N,N',P-L)] (M = Rh (1), Ir (2)) react with AgSbF6 in a 1/2 molar ratio affording the bis-acetonitrile complexes [M(κ4C,N,N',P-L)(NCMe)2][SbF6]2 (3, 4). The reaction takes place in a sequential manner and the intermediates can be isolated varying the M/Ag molar ratio. In a 2/1 molar ratio, it affords the dimetallic monochlorido-bridged compounds [{MCl(κ4C,N,N',P-L)}2(μ-Cl)][SbF6] (5, 6). In a 1/1 molar ratio, the monosubstituted solvato-complexes [MCl(κ4C,N,N',P-L)(Solv)][SbF6] (Solv = H2O, MeCN, 7-10) were obtained...
July 27, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28749046/pot-economical-total-synthesis-of-estradiol-methyl-ether-through-the-use-of-an-organocatalyst
#4
Yujiro Hayashi, Seitaro Koshino, Kanna Ojima, Eunsang Kwon
Enantioselective total synthesis of estradiol methyl ether has been accomplished in a pot economical manner using five reaction vessels with four purifications. The key reaction is diphenylprolinol silyl ether mediated domino Michael/aldol reaction to afford bicyclo[4.3.0]nonane derivatives with A, C and D rings of steroids as a single isomer with excellent enantioselectivity. Six reactions such as oxidation, hydrogenation, formation of acid chloride, Friedel-Crafts reaction, deprotection and reduction can be carried out in the last one-pot sequence...
July 27, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28749036/advantages-of-rna-seq-compared-to-rna-microarrays-for-transcriptome-profiling-of-anterior-cruciate-ligament-tears
#5
Muhammad Farooq Rai, Eric D Tycksen, Linda J Sandell, Robert H Brophy
Microarrays and RNA-seq are at the forefront of high throughput transcriptome analyses. Since these methodologies are based on different principles there are concerns about the concordance of data between the two techniques. The concordance of RNA-seq and microarrays for genome-wide analysis of differential gene expression has not been rigorously assessed in clinically derived ligament tissues. To demonstrate the concordance between RNA-seq and microarrays and to assess potential benefits of RNA-seq over microarrays, we assessed differences in transcript expression in anterior cruciate ligament (ACL) tissues based on time-from-injury...
July 27, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28749006/highly-cis-1-4-selective-living-polymerization-of-unmasked-polar-2-2-methylidenebut-3-enyl-furan-and-diels-alder-addition
#6
Shiyu Long, Fei Lin, Changguang Yao, Dongmei Cui
The polymerization of a new polar diene-based monomer 2-(2-methylidenebut-3-enyl)furan (MBEF) without masking is achieved by using the bis(phosphino)carbazoleide-ligated yttrium (Y) alkyl complex upon the activation of [Ph3 C][B(C6 F5 )4 ]. Under mild conditions, the polymerizations under the monomer-to-Y ratios ranging from 100:1 to 500:1 perform fluently in high yields. The afforded polydienes bearing pendant terminal furan groups have high cis-1,4-regularity up to 98.6% and molecular weights close to the theoretic values and narrow polymer dispersity index(PDI) (1...
July 27, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28748700/wittig-cyclization-of-%C3%AF-hydroxy-hemiacetals-synthesis-of-aspicilin
#7
René Schmidt, Michael Ostermeier, Rainer Schobert
The polyhydroxylated 18-membered lichen macrolide (+)-aspicilin was synthesized in 12 steps and 17% yield (longest linear sequence) starting from D-mannose and (S)-propylene oxide as the source of the stereogenic centers. Key steps were a palladium-catalyzed Csp3X-Csp3ZnX Negishi cross-coupling affording an ω-hydroxy hemiacetal which was macrocyclized via a domino addition-Wittig olefination reaction with the cumulated ylide Ph3PCCO. This synthetic approach also allowed a regioselective glycosylation of 6-OH of aspicilin with D desosamine, a quick entry to chimeric macrolides with potential antibiotic activity...
July 27, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28748612/sol-gel-adsorbent-coated-extraction-needles-to-detect-volatile-compounds-in-spoiled-fish
#8
Ye-Jin Bang, Yura Hwang, Soyoung Lee, Soomi Park, Sunyoung Bae
Volatile compounds generated by fish spoilage were investigated by an inside-needle microextraction method followed by gas chromatography with flame ionization detection and gas chromatography with mass spectrometry. The inside of a needle was coated with an adsorbent to extract the target analytes from the headspace of the sample. The examined adsorbents included β-cyclodextrin, polystyrene resin cross-linked with 1% divinylbenzene, and polyethylene glycol mixed with polydimethylsiloxane. The investigated volatile compounds generated by fish spoilage were acetone, 2-butanone, 2-butanol, 2-propanol, dimethyl disulfide, acetic acid, and benzaldehyde...
July 27, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28748577/selective-conversion-of-p-o-bridged-rhodamines-into-p-o-rhodols-solvatochromic-near-infrared-fluorophores
#9
Marek Grzybowski, Masayasu Taki, Shigehiro Yamaguchi
The substitution of an oxygen atom in rhodols with a phosphine oxide (P=O) moiety affords P=O-bridged rhodols as a new type of near-infrared (NIR) fluorophores. This compound class can be readily accessed upon exposure of the corresponding rhodamines to aqueous basic conditions. The electron-withdrawing effect of the P=O group facilitates the hydrolytic deamination, and, moreover, prolonged exposure to aqueous basic conditions generates P=O-bridged fluoresceins, i.e., a series of three P=O-bridged xanthene dyes is available in one simple operation...
July 27, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28748450/replicating-health-economic-models-firm-foundations-or-a-house-of-cards
#10
Inigo Bermejo, Paul Tappenden, Ji-Hee Youn
Health economic evaluation is a framework for the comparative analysis of the incremental health gains and costs associated with competing decision alternatives. The process of developing health economic models is usually complex, financially expensive and time-consuming. For these reasons, model development is sometimes based on previous model-based analyses; this endeavour is usually referred to as model replication. Such model replication activity may involve the comprehensive reproduction of an existing model or 'borrowing' all or part of a previously developed model structure...
July 26, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28748312/the-extended-object-grasping-network
#11
REVIEW
Marzio Gerbella, Stefano Rozzi, Giacomo Rizzolatti
Grasping is the most important skilled motor act of primates. It is based on a series of sensorimotor transformations through which the affordances of the objects to be grasped are transformed into appropriate hand movements. It is generally accepted that a circuit formed by inferior parietal areas AIP and PFG and ventral premotor area F5 represents the core circuit for sensorimotor transformations for grasping. However, selection and control of appropriate grip should also depend on higher-order information, such as the meaning of the object to be grasped, and the overarching goal of the action in which grasping is embedded...
July 26, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28748063/field-application-of-the-micro-biological-survey-method-for-the-assessment-of-the-microbiological-safety-of-different-water-sources-in-horn-of-africa-and-the-evaluation-of-the-effectiveness-of-moringa-oleifera-in-drinking-water-purification
#12
Francesca Losito, Alyexandra Arienzo, Daniela Somma, Lorenza Murgia, Ottavia Stalio, Paolo Zuppi, Elisabetta Rossi, Giovanni Antonini
Water monitoring requires expensive instrumentations and skilled technicians. In developing Countries as Africa, the severe economic restrictions and lack of technology make water safety monitoring approaches applied in developed Countries, still not sustainable. The need to develop new methods that are suitable, affordable, and sustainable in the African context is urgent. The simple, economic and rapid Micro Biological Survey (MBS) method does not require an equipped laboratory nor special instruments and skilled technicians, but it can be very useful for routine water analysis...
June 23, 2017: Journal of Public Health in Africa
https://www.readbyqxmd.com/read/28747706/titanium-dioxide-engineered-for-near-dispersionless-high-terahertz-permittivity-and-ultra-low-loss
#13
Chuying Yu, Yang Zeng, Bin Yang, Robert Donnan, Jinbao Huang, Zhaoxian Xiong, Amit Mahajan, Baogui Shi, Haitao Ye, Russell Binions, Nadezda V Tarakina, Mike J Reece, Haixue Yan
Realising engineering ceramics to serve as substrate materials in high-performance terahertz(THz) that are low-cost, have low dielectric loss and near-dispersionless broadband, high permittivity, is exceedingly demanding. Such substrates are deployed in, for example, integrated circuits for synthesizing and converting nonplanar and 3D structures into planar forms. The Rutile form of titanium dioxide (TiO2) has been widely accepted as commercially economical candidate substrate that meets demands for both low-loss and high permittivities at sub-THz bands...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747600/severe-combined-immunodeficiency-from-its-discovery-to-the-perspective
#14
Hirokazu Kanegane, Kohsuke Imai, Tomohiro Morio
  Severe combined immunodeficiency (SCID) is impaired in lymphocyte development and function. Affected children have extreme susceptibility to infections, which are fatal in the first year of life without treatment. The estimate of incidence is one in approximately 50,000 live birth. The first series of diseases were described in 1950s, and all patients died in infancy. The first transplant for SCID was carried out in 1968, and it has been described that SCID patients could be treated by hematopoietic stem cell transplantation (HSCT) since then...
2017: Nihon Rinshō Men'eki Gakkai Kaishi, Japanese Journal of Clinical Immunology
https://www.readbyqxmd.com/read/28747321/the-affordable-care-act-reduced-socioeconomic-disparities-in-health-care-access
#15
Kevin Griffith, Leigh Evans, Jacob Bor
The United States has the largest socioeconomic disparities in health care access of any wealthy country. We assessed changes in these disparities in the United States under the Affordable Care Act (ACA). We used survey data for the period 2011-15 from the Behavioral Risk Factor Surveillance System to assess trends in insurance coverage, having a personal doctor, and avoiding medical care due to cost. All analyses were stratified by household income, education level, employment status, and home ownership status...
July 26, 2017: Health Affairs
https://www.readbyqxmd.com/read/28747237/mental-health-care-utilisation-among-internally-displaced-persons-in-ukraine-results-from-a-nation-wide-survey
#16
B Roberts, N Makhashvili, J Javakhishvili, A Karachevskyy, N Kharchenko, M Shpiker, E Richardson
Aims There are an estimated 1.5 million internally displaced persons (IDPs) in Ukraine because of the armed conflict in the east of the country. The aim of this paper is to examine utilisation patterns of mental health and psychosocial support (MHPSS) care among IDPs in Ukraine. METHODS: A cross-sectional survey design was used. Data were collected from 2203 adult IDPs throughout Ukraine between March and May 2016. Data on mental health care utilisation were collected, along with outcomes including post-traumatic stress disorder (PTSD), depression and anxiety...
July 27, 2017: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/28746878/the-type-vi-secretion-system-engages-a-redox-regulated-dual-functional-heme-transporter-for-zinc-acquisition
#17
Meiru Si, Yao Wang, Bing Zhang, Chao Zhao, Yiwen Kang, Haonan Bai, Dawei Wei, Lingfang Zhu, Lei Zhang, Tao G Dong, Xihui Shen
The type VI secretion system was recently reported to be involved in zinc acquisition, but the underlying mechanism remains unclear. Here, we report that Burkholderia thailandensis T6SS4 is involved in zinc acquisition via secretion of a zinc-scavenging protein, TseZ, that interacts with the outer membrane heme transporter HmuR. We find that HmuR is a redox-regulated dual-functional transporter that transports heme iron under normal conditions but zinc upon sensing extracellular oxidative stress, triggered by formation of an intramolecular disulfide bond...
July 25, 2017: Cell Reports
https://www.readbyqxmd.com/read/28746766/conservation-genetics-precision-conservation-and-de-extinction
#18
Rob Desalle, George Amato
It has been estimated that three species on the planet now go extinct every hour and that this rate is orders of magnitude higher than the planet has seen in previous catastrophic extinction events. We clearly are in the midst of a sixth extinction, and this one is different from the previous five. Why? This sixth extinction is caused by the activity of a single species-us. If there is any hope of ameliorating this extinction, it will entirely be up to us, as the current stewards of this planet, to change the course...
July 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28746742/forging-quaternary-fluorine-stereocenters-by-a-light-driven-organocatalytic-aldol-desymmetrization-process
#19
Sara Cuadros, Luca Dell'Amico, Paolo Melchiorre
Reported herein is a light-triggered organocatalytic strategy for the desymmetrization of achiral 2-fluoro substituted cyclopentane-1,3-diketones. The chemistry is based on an intermolecular aldol reaction of photochemically generated hydroxy-o-quinodimethanes that simultaneously forges two adjacent fully substituted carbon stereocenters, one bearing a carbon-fluorine stereogenic unit. The method uses readily available substrates, a simple chiral organocatalyst, and mild reaction conditions to afford an array of highly functionalized chiral 2-fluoro-3-hydroxycyclopentanones...
July 26, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28745885/chemical-synthesis-demonstrates-dynamic-o-glycosylation-regulates-folding-and-functional-conformation-of-a-pivotal-egf12-domain-of-human-notch1-receptor
#20
Shun Hayakawa, Yasuhiro Yokoi, Hiroshi Hinou, Shin-Ichiro Nishimura
The interaction of human NOTCH1 receptor and its ligands is a crucial step to initiate the intracellular signal transductions, in which O-glycosylation of the extracellular EGF-like domain is known to modify this pathway that strongly affects multiple aspects of cell differentiation, development, and cancer biology. In spite of the emerging importance of O-glycosylation in the NOTCH signaling pathway, consequences of this dynamic O-glycosylation processes in ER/Golgi on the folding of functional EGF-like domains re-main unclear...
July 26, 2017: Biochemistry
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