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https://www.readbyqxmd.com/read/29755904/radiation-induced-cavernous-malformation-as-a-late-sequelae-of-stereotactic-radiosurgery-for-epilepsy
#1
Ethan A Winkler, Caleb Rutledge, Mariann Ward, Tarik Tihan, Patricia K Sneed, Nicholas Barbaro, Paul Garcia, Michael McDermott, Edward F Chang
Stereotactic radiosurgery (SRS) is a promising treatment for medically intractable mesial temporal lobe epilepsy. SRS for epilepsy has had an acceptable safety profile with reports of radiation-induced vascular malformations confined to central nervous system pathologies with prominent angiogenesis - namely, primary brain tumors, metastases, and arteriovenous malformations. Theoretical risks for radiation-induced lesions following radiosurgery for epilepsy have yet to be established. Of 13 patients treated in a pilot trial for medial temporal lobe epilepsy, one developed multiple delayed radiation-induced cavernous malformations following radiosurgery...
March 11, 2018: Curēus
https://www.readbyqxmd.com/read/29747348/-cerebral-cavernous-malformation-3-gene-deficiency-promotes-early-changes-in-alzheimer-disease-like-lesions-induced-by-low-lead-exposure
#2
S Wu, D Xia, H X Liu, H P Zhao, X H Wang, Y F Gao, Z Q Zhao, C Xiao, X M Xing, Y He
Objective: To investigate the effects of cerebral cavernous malformation 3 (CCM3) gene knockout on the lead exposure-induced blood-brain barrier malfunction in mice brain, and the relationship between CCM3 knockout and the Alzheimer's disease (AD). Methods: Wide type (WT) mice and CCM3(+)/- mice were divided into 4 groups, control group and lead exposed group in WT as well as CCM3(+/-) mice. Lead exposed groups were treated with 0.05% lead acetate in drinking water for 12 weeks, while control group drink deionized water freely...
May 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29726796/chronic-encapsulated-intraventricular-hematoma-in-a-pediatric-patient-case-report
#3
Jeremy Wetzel, David Bray, David Wrubel
Chronic encapsulated intraventricular hematoma (CEIVH) is a rare, intraventricular, nonneoplastic mass lesion that can become symptomatic from mass effect or obstructive hydrocephalus. Only 5 cases have been reported in the literature, and only one of these occurred in a pediatric patient and dates back to the pre-modern neuroimaging and pre-microsurgical era of neurosurgery. Imaging features can mimic those of many more common intraventricular lesions, such as choroid plexus tumors or cavernous malformations...
May 4, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29720384/plasma-biomarkers-of-inflammation-and-angiogenesis-predict-cerebral-cavernous-malformation-symptomatic-hemorrhage-or-lesional-growth
#4
Romuald Girard, Hussein A Zeineddine, Janne Koskimaki, Maged D Fam, Ying Cao, Changbin Shi, Thomas J Moore, Rhonda Lightle, Agnieszka Stadnik, Kiranj K Chaudager, Sean P Polster, Robert Shenkar, Ryan C Duggan, David Leclerc, Kevin J Whitehead, Dean Li, Issam A Awad
<u>Rationale:</u> The clinical course of cerebral cavernous malformations (CCMs) is highly unpredictable, with few cross-sectional studies correlating pro-inflammatory genotypes and plasma biomarkers with prior disease severity. <u>Objective:</u> We hypothesize that a panel of 24 candidate plasma biomarkers, with a reported role in the physiopathology of CCMs, may predict subsequent clinically relevant disease activity. <u>Methods and Results:</u> Plasma biomarkers were assessed in non-fasting peripheral venous blood collected from consecutive CCM subjects followed for one year after initial sample collection...
May 2, 2018: Circulation Research
https://www.readbyqxmd.com/read/29697019/frontal-lobe-cavernous-malformations-in-pediatric-patients-clinical-features-and-surgical-outcomes
#5
Chengjun Wang, Meng Zhao, Jia Wang, Shuo Wang, Zhongli Jiang, Jizong Zhao
The purpose of this study is to investigate the clinical manifestations, surgical treatment, and neurologic outcomes of frontal lobe cavernous malformations in children. A retrospective analysis of 23 pediatric frontal lobe cavernous malformation patients who underwent surgical treatment in Beijing Tiantan Hospital was performed. The case series included 16 boys and 7 girls. Gross total removal without surgical mortality was achieved in all patients. The mean follow-up period after surgery was 33.1 months. Two patients who left hospital with motor deficits gradually recovered after rehabilitative treatment, and other patients were considered to be in excellent clinical condition...
January 1, 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29682072/venous-malformation-cavernous-hemangioma-of-the-supraorbital-nerve
#6
Jung-Hoon Kim, Jin-Gyu Choi, Byung-Chul Son
Cavernous hemangiomas are not true vascular tumors, but rather are slow-flow venous malformations (VMs). They are present at birth as nonproliferating vascular birthmarks composed of anomalous ectatic venous channels. VMs have often been incorrectly called cavernous hemangiomas and cavernous angiomas. These terms have for a long time lead to confusion with the more common proliferating or true hemangioma of infancy. VM has been reported to arise at all sites including skin and subcutaneous layers of the head and neck, face, extremities, liver, gastrointestinal tract, and even the thymus...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29682056/occipital-neuralgia-from-c2-cavernous-malformation
#7
Sang-Woo Ha, Jin-Gyu Choi, Byung-Chul Son
A unique case is presented of chronic occipital neuralgia (ON) caused by cavernous malformation (CM) in the intramedullary C2 spinal cord and subsequent pain relief and remodeling of allodynic pain following dorsal root rhizotomy. A 53-year-old male presented with a 30-year history of chronic allodynic, paroxysmal lancinating pain in the greater and lesser occipital nerves. Typically, the pain was aggravated with neck extension and head movement. Magnetic resonance imaging showed a CM in the right posterolateral side of the intramedullary C2 cord...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29677701/surgical-treatment-and-long-term-outcome-of-cerebral-cavernous-malformations-related-epilepsy-in-pediatric-patients
#8
Qiao Lin, Peng-Fan Yang, Yan-Zeng Jia, Jia-Sheng Pei, Hui Xiao, Ting-Ting Zhang, Zhong-Hui Zhong, Shou-Sen Wang
Cerebral cavernous malformations (CMs) are vascular malformations affecting any part of the central nervous system. Clinical data and surgical outcomes for 27 pediatric patients with CM-related epilepsy were retrospectively reviewed. The mean age of onset was 12.71 ± 4.09 years, and the mean duration of epilepsy was 2.34 ± 1.95 years. All 27 patients were treated with microsurgery for resection of the CMs, and the hemosiderin rim, and the secondary epileptogenic zone if necessary. The mean follow-up period was 6...
April 20, 2018: Neuropediatrics
https://www.readbyqxmd.com/read/29649643/estimating-the-global-incidence-of-aneurysmal-subarachnoid-hemorrhage-a-systematic-review-for-central-nervous-system-vascular-lesions-and-meta-analysis-of-ruptured-aneurysms
#9
REVIEW
Joshua D Hughes, Kamila M Bond, Rania A Mekary, Michael C Dewan, Abbas Rattani, Ronnie Baticulon, Yoko Kato, Hildo Azevedo-Filho, Jacques J Morcos, Kee B Park
INTRODUCTION: There is increasing acknowledgement that surgical care is important in global health initiatives. In particular, neurosurgical care is as limited as 1-to-10 million people in parts of the world. We performed a systematic literature review to examine the worldwide incidence of central nervous system vascular lesions (CNS-VL) and a meta-analysis of aneurysmal subarachnoid hemorrhage (ASAH) in order to define the disease burden and inform neurosurgical global health efforts...
April 9, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29621076/multiple-intracranial-cavernous-angiomas-with-a-trigonal-cavernous-angioma-mimicking-glioma
#10
Jie Wu, Rijun Ren, Zhaoyou Qiu, Maokai Wang
Intracranial cavernous angiomas (CAs) are hamartomatous vascular malformations consisting of thin-walled vascular channels located within the brain, but typically lacking intervening neural parenchyma, large feeding arteries, or draining veins. The CAs occurring in the ventricular system are rare, with an incidence of 2.5% to 10.3% of the intracranial CAs, and those arising from the trigone of the lateral ventricle are even rarer. Till now, there are <20 patients with trigonal CAs have been reported in the English literature...
April 4, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29613893/vascular-disorders-of-the-spinal-cord
#11
Christopher L Kramer
PURPOSE OF REVIEW: Prompt recognition and timely management of vascular disorders of the spinal cord can improve patient outcomes. This article provides contemporary and practical knowledge about the most common vascular myelopathies. RECENT FINDINGS: New studies have provided additional information on the risk factors and impact of neurologic monitoring on perioperative spinal cord infarction. Additionally, recent publications have provided information on the impact of misdiagnosis, corticosteroid treatment, and postoperative prognosis in the treatment of spinal dural arteriovenous fistulas and have discussed the outcome of patients with spinal arteriovenous malformations treated with embolization, surgery, and stereotactic radiosurgery...
April 2018: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/29609087/the-tonsillouvular-fissure-approach-access-to-dorsal-and-lateral-aspects-of-the-fourth-ventricle
#12
Ilhan Aydin, Sahin Hanalioglu, Halil Olgun Peker, Yahya Turan, Hakan Kina, Ulas Cikla, Mustafa K Baskaya
OBJECTIVE: Although approaches to the fourth ventricle (FV) have been studied well, approaches to the lesions located in the dorsal and lateral aspects of the FV have not been demonstrated in anatomical or clinical studies. The aim of present study is to demonstrate the tonsillouvular fissure approach (TUFA) in anatomical dissections and its utilization in surgical series for the first time in the literature. METHODS: For anatomical studies, four formalin-fixed human cadaveric heads infused with colored silicone and ten cerebellar specimens were dissected in a stepwise manner...
March 30, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29609039/computer-aided-diagnosis-of-cavernous-malformations-in-brain-mr-images
#13
Huiquan Wang, S Nizam Ahmed, Mrinal Mandal
Cavernous malformation or cavernoma is one of the most common epileptogenic lesions. It is a type of brain vessel abnormality that can cause serious symptoms such as seizures, intracerebral hemorrhage, and various neurological disorders. Manual detection of cavernomas by physicians in a large set of brain MRI slices is a time-consuming and labor-intensive task and often delays diagnosis. In this paper, we propose a computer-aided diagnosis (CAD) system for cavernomas based on T2-weighted axial plane MRI image analysis...
June 2018: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/29605477/susceptibility-weighted-magnetic-resonance-imaging-of-cerebrovascular-sequelae-after-radiotherapy-for-pediatric-brain-tumors
#14
Marie A Neu, Yasemin Tanyildizi, Arthur Wingerter, Nicole Henninger, Khalifa El Malki, Francesca Alt, Barbara Doerr, Heinz Schmidberger, Marcus Stockinger, Wolfgang Wagner, Stefanie Keweloh, Marc A Brockmann, Alexandra Russo, Joerg Faber
BACKGROUND AND PURPOSE: Due to sensitive neuroimaging techniques, cerebrovascular complications such as cerebral microbleeds (CMB) and cerebral cavernous malformations (CCM) are increasingly recognized as considerable late effects after treatment for pediatric brain tumor. The aim of this study was to analyze CMB in a cohort of patients after cranial irradiation therapy for medulloblastoma or other pediatric brain tumors using susceptibility-weighted magnetic resonance imaging (SWI). MATERIALS AND METHODS: Forty former pediatric brain tumor patients were enrolled in this prospective cross-sectional study and examined by cranial MRI including SWI sequences...
March 28, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29593473/cerebral-cavernous-malformations-an-update-on-prevalence-molecular-genetic-analyses-and-genetic-counselling
#15
REVIEW
Stefanie Spiegler, Matthias Rath, Christin Paperlein, Ute Felbor
Based on the latest gnomAD dataset, the prevalence of symptomatic hereditary cerebral cavernous malformations (CCMs) prone to cause epileptic seizures and stroke-like symptoms was re-evaluated in this review and calculated to be 1:5,400-1:6,200. Furthermore, state-of-the-art molecular genetic analyses of the known CCM loci are described which reach an almost 100% mutation detection rate for familial CCMs if whole genome sequencing is performed for seemingly mutation-negative families. An update on the spectrum of CCM1 , CCM2 , and CCM3 mutations demonstrates that deep-intronic mutations and submicroscopic copy-number neutral genomic rearrangements are rare...
February 2018: Molecular Syndromology
https://www.readbyqxmd.com/read/29588956/high-frequency-oscillations-detected-in-ecog-recordings-correlate-with-cavernous-malformation-and-seizure-free-outcome-in-a-child-with-focal-epilepsy-a-case-report
#16
Su Liu, Michael M Quach, Daniel J Curry, Monika Ummat, Elaine Seto, Nuri F Ince
Epilepsy associated with cavernous malformation (CM) often requires surgical resection of seizure focus to achieve seizure-free outcome. High-frequency oscillations (HFOs) in intracranial electroencephalogram (EEG) are reported as potential biomarkers of epileptogenic regions, but to our knowledge there are no data on the existence of HFOs in CM-caused epilepsy. Here we report our experience of the identification of the seizure focus in a 3-year-old pediatric patient with intractable epilepsy associated with CM...
June 2017: Epilepsia Open
https://www.readbyqxmd.com/read/29588900/interhemispheric-translamina-terminalis-approach-for-the-resection-of-suprasellar-cavernous-malformation
#17
Georgios A Zenonos, Paul A Gardner
Objectives  The current video presents the nuances of an interhemispheric, translamina terminalis approach for the resection of suprasellar cavernous malformation. Design  The video analyzes the presentation, preoperative workup and imaging, surgical steps and technical nuances of the surgery, the clinical outcome, and follow-up imaging. Setting  The patient was treated by a skull base team at a teaching academic institution. Participants  The case refers to a 64-year-old female who presented with vision loss and confusion, and was found to have a suprasellar mass, with imaging characteristics consistent with a cavernous malformation of the third ventricle...
April 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29570519/cystic-progression-of-a-cavernous-malformation-at-the-level-of-the-trigeminal-root-entry-zone-presenting-with-sudden-onset-of-trigeminal-neuralgia
#18
Carlo Giacobbo Scavo, Raffaelino Roperto, Guglielmo Cacciotti, Luciano Mastronardi
BACKGROUND: Cavernous malformations (CM) in the cerebellopontine angle (CPA) are rare, and most of them are solid and extend from the internal auditory canal into the CPA. In contrast, cystic CM arising in the CPA and not involving the internal auditory canal and dura of the skull base are extremely rare. The authors present an uncommon large cystic progression of a cavernous malformation at the level of the trigeminal root entry zone evolving to severe trigeminal neuralgia and brainstem compression...
March 22, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29548952/cerebellar-proliferative-angiopathy-associated-with-a-pontine-telangiectasia-and-a-developmental-venous-anomaly
#19
Marcelo D Vilela, Uedson Tazinaffo
Various mixed associations between arteriovenous malformations, cavernous malformations, developmental venous anomalies and capillary telangiectasias have been described and a common pathophysiological event has been suggested to be present, although yet to be elucidated. We depict herein the imaging features of a patient who presented with a spontaneous cerebellar hemorrhage, in whom radiological studies demonstrated a pontine telangiectasia, a brainstem/cerebellar developmental venous anomaly and a cerebellar proliferative angiopathy...
March 13, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29547081/surgical-outcome-of-motor-deficits-and-neurological-status-in-brainstem-cavernous-malformations-based-on-preoperative-diffusion-tensor-imaging-a-prospective-randomized-clinical-trial
#20
Da Li, Yu-Ming Jiao, Liang Wang, Fu-Xin Lin, Jun Wu, Xian-Zeng Tong, Shuo Wang, Yong Cao
OBJECTIVE Surgical management of brainstem lesions is challenging due to the highly compact, eloquent anatomy of the brainstem. This study aimed to evaluate the safety and efficacy of preoperative diffusion tensor imaging (DTI) and diffusion tensor tractography (DTT) in brainstem cavernous malformations (CMs). METHODS A prospective randomized controlled clinical trial was performed by using stratified blocked randomization. The primary eligibility criterion of the study was being a surgical candidate for brainstem CMs (with informed consent)...
March 16, 2018: Journal of Neurosurgery
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