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https://www.readbyqxmd.com/read/29764718/metabolic-syndrome-associates-with-left-atrial-dysfunction
#1
K Nyman, M Granér, M O Pentikäinen, J Lundbom, A Hakkarainen, R Sirén, M S Nieminen, M-R Taskinen, N Lundbom, K Lauerma
BACKGROUND AND AIMS: Obesity and metabolic syndrome (MetS) are risk factors of atrial fibrillation (AF), but limited data exist on their effect on left atrial (LA) function. The aim of the study was to evaluate the effects of cardiac, hepatic and intra-abdominal ectopic fat depots and cardiometabolic risk factors on LA function in non-diabetic male subjects. METHODS AND RESULTS: Myocardial and hepatic triglyceride contents were measured with 1.5T 1 H-magnetic resonance spectroscopy and LA and left ventricular function, visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), epicardial and pericardial fat by magnetic resonance imaging (MRI) in 33 men with MetS and 40 men without MetS...
February 21, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29748197/minimally-invasive-delivery-of-hydrogel-encapsulated-amiodarone-to-the-epicardium-reduces-atrial-fibrillation
#2
Jose R Garcia, Peter F Campbell, Gautam Kumar, Jonathan J Langberg, Liliana Cesar, Juline N Deppen, Eric Y Shin, Neal K Bhatia, Lanfang Wang, Kai Xu, Frank Schneider, Brian Robinson, Andrés J García, Rebecca D Levit
BACKGROUND: Atrial fibrillation (AF) is the most common cardiac arrhythmia. Although treatment options for AF exist, many patients cannot be maintained in normal sinus rhythm. Amiodarone is an effective medication for AF but has limited clinical utility because of off-target tissue toxicity. METHODS: Here, we use a pig model of AF to test the efficacy of an amiodarone-containing polyethylene glycol-based hydrogel. The gel is placed directly on the atrial epicardium through the pericardial space in a minimally invasive procedure using a specially designed catheter...
May 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29748196/interleukin-10-treatment-ameliorates-high-fat-diet-induced-inflammatory-atrial-remodeling-and-fibrillation
#3
(no author information available yet)
BACKGROUND: Obesity, characterized by systemic low-grade inflammation, is considered a well-known risk for atrial fibrillation. In fact, IL-10 (interleukin 10), which is a potent anti-inflammatory cytokine, has been reported to decrease in obese and diabetic patients. We tested the hypotheses forwarding that genetic deletion of IL-10 exacerbates high-fat diet (HFD)-induced obesity-caused atrial inflammation, lipidosis, fibrosis, and fibrillation and that IL-10 therapy inhibits this pathology...
May 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29682734/the-role-of-pericardial-adipose-tissue-in-the-heart-of-obese-minipigs
#4
Chia-Yu Wang, Sin-Jin Li, Twin-Way Wu, Han-Jen Lin, Jyun-Wei Chen, Harry J Mersmann, Shih-Torng Ding, Ching-Yi Chen
BACKGROUND: Pericardial adipose tissue (PAT) volume is highly associated with the presence and severity of cardiometabolic diseases, but the underlying mechanism is unknown. We previously demonstrated that a high-fat diet (HFD) induced metabolic dysregulation, cardiac fibrosis, and accumulation of more PAT in minipigs. This study used our obese minipig model to investigate the characteristics of PAT and omental visceral fat (VAT) induced by a HFD, and the potential link between PAT and HFD-related myocardial fibrosis...
April 23, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29675684/the-role-of-epicardial-fat-in-pericardial-diseases
#5
REVIEW
George Lazaros, Alexios Antonopoulos, Charalambos Antoniades, Dimitris Tousoulis
PURPOSE OF REVIEW: Despite the recent advancements in diagnostic modalities and therapeutic options available, the pathophysiology of pericardial syndromes remains poorly understood. In this review article, we explore the possible links between cardiac adiposity and pericardial syndromes. RECENT FINDINGS: Over the last years, the notion of cardiac adipose tissue has radically changed, and its pivotal role in myocardial diseases has been acknowledged. Recent evidence suggests a cross-talk between epicardial fat and the heart...
April 19, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29622445/pericardial-fat-as-a-new-independent-biomarker-of-vascular-aging
#6
EDITORIAL
Arrigo F G Cicero, Federica Fogacci
No abstract text is available yet for this article.
June 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29622443/pericardial-and-visceral-but-not-total-body-fat-are-related-to-global-coronary-and-extra-coronary-atherosclerotic-plaque-burden
#7
Gaston A Rodriguez-Granillo, Exequiel Reynoso, Carlos Capunay, Jimena Carpio, Patricia Carrascosa
BACKGROUND: To explore the relationship between coronary and extra-coronary atherosclerotic plaque burden with total and regional fat depots among patients undergoing ECG-gated aortic computed tomography angiography (CTA). METHODS: The subjects of this study comprised a cohort of consecutive patients who underwent ECG-gated thoracoabdominal CTA. We assessed the number of coronary segments with plaques (segment-involvement score, SIS); and the extra-coronary atherosclerotic plaque burden, comprising the aorta and supra-aortic trunks, iliofemoral arteries, and visceral arteries (extra-coronary SS)...
June 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29618325/chylopericardium-in-a-child-with-iga-nephropathy-a-case-report
#8
Yu-Lin Kang, Yun Cui, Ying Wu, Shen Hao, Xin-Yu Kuang, Yu-Cai Zhang, Wen-Yan Huang, Guang-Hua Zhu
BACKGROUND: Chylopericardium effusion is characterized by the accumulation of milky effusion in the pericardium. It is often idiopathic but it can be secondary to trauma, chest radiation, tuberculosis and malignancy. If cardiac tamponade ensues, it becomes life-threatening. Herein we describe chylopericardium tamponade in a child with IgA nephropathy. To the best of our knowledge, this is the first reported case of chylopericardium tamponade in IgA nephropathy. CASE PRESENTATION: A 6 years old boy with IgA nephropathy presented with dyspnea, orthopnea, pretibial pitting edema, ascites and fever...
April 5, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29601409/correlation-of-mri-derived-adipose-tissue-measurements-and-anthropometric-markers-with-prevalent-hypertension-in-the-community
#9
Roberto Lorbeer, Susanne Rospleszcz, Christopher L Schlett, Sophia D Heber, Jürgen Machann, Barbara Thorand, Christa Meisinger, Margit Heier, Annette Peters, Fabian Bamberg, Wolfgang Lieb
OBJECTIVES: To compare the correlations of MRI-derived adipose tissue measurements and anthropometric markers, respectively, with prevalent hypertension in a community-based sample, free of clinical cardiovascular disease. METHODS: MRI-derived adipose tissue measurements were obtained in 345 participants (143 women; age 39-73 years) of the KORA FF4 survey from Southern Germany using a 3-Tesla machine and included total adipose tissue (TAT), visceral adipose tissue (VAT), subcutaneous adipose tissue (SCAT), hepatic fat fraction (HFF), pancreatic fat fraction (PFF) as well as pericardial adipose tissue (PAT)...
March 29, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29518370/visceral-and-intrahepatic-fat-are-associated-with-cardiometabolic-risk-factors-above-other-ectopic-fat-depots-the-framingham-heart-study
#10
Jane J Lee, Alison Pedley, Udo Hoffmann, Joseph M Massaro, Daniel Levy, Michelle T Long
BACKGROUND: We examined the associations among 8 different fat depots accumulated in various anatomic regions and the relationship between these fat depots and multiple cardiometabolic risk factors. METHODS: Participants were from the Framingham Heart Study Offspring and Third Generation who also participated in the multidetector computed tomography substudy in 2002-2005. Exposures were multidetector computed tomography-derived fat depots, including abdominal subcutaneous adipose tissue, abdominal visceral adipose tissue, intramuscular fat, intrathoracic fat, pericardial fat, thoracic periaortic fat, intrahepatic fat, and renal sinus fat...
March 5, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29517280/index-of-cardiac-electrophysiological-balance-and-transmural-dispersion-of-the-repolarization-index-relationships-with-pericardial-fat-volume-and-coronary-calcification
#11
Hussein Nafakhi, Abdulameer A Al-Mosawi, Mohammed Alareedh, Hasan A Al-Nafakh
AIM: To assess the possible relationship between coronary atherosclerosis markers, pericardial fat volume (PFV) and coronary artery calcification, with ECG markers of index of the cardiac electrophysiological balance (iCEB) and transmural dispersion of the repolarization in patients with suspected coronary artery disease. METHODOLOGY: One hundred patients who underwent 64-slice multidetector computed tomography angiography were found to be eligible and were enrolled in the study...
April 2018: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29507707/survival-based-radiographic-grouping-for-esophageal-squamous-cell-carcinoma-may-impact-clinical-t-stage
#12
Wenjie Cai, Jiade J Lu, Rongyu Xu, Peiling Xin, Jun Xin, Yayun Chen, Bingzhong Gao, Jieyun Chen, Xiyang Yang
Most patients diagnosed with thoracic esophageal squamous cell carcinoma (ESCC) have progressed beyond surgical resection as a therapeutic option. Difficulties in the proper assessment of tumor invasion depth before treatment complicate determination of the type and extent of therapy. Therefore, accurate tumor clinical staging is a necessity for identifying treatment options and aiding in patient prognosis. We investigated radiographic factors as prognostic indicators for survival in ESCC. Between July 2006 - July 2010, 324 thoracic ESCC patients who underwent surgery were selected...
February 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29463919/sex-dimorphic-acceleration-of-pericardial-subcutaneous-and-plasma-lipid-increase-in-offspring-of-poorly-nourished-baboons
#13
Anderson H Kuo, Cun Li, Vicki Mattern, Hillary F Huber, Anthony Comuzzie, Laura Cox, Matthias Schwab, Peter W Nathanielsz, Geoffrey D Clarke
Developmental programming by reduced maternal nutrition alters function in multiple offspring physiological systems, including lipid metabolism. We have shown that intrauterine growth restriction (IUGR) leads to offspring cardiovascular dysfunction with an accelerated aging phenotype in our nonhuman primate, baboon model. We hypothesized age-advanced pericardial fat and blood lipid changes. In pregnancy and lactation, pregnant baboons ate ad lib (control) or 70% ad lib diet (IUGR). We studied baboon offspring pericardial lipid deposition with magnetic resonance imaging at 5-6 years (human equivalent 20-24 years), skinfold thickness, and serum lipid profile at 8-9 years (human equivalent 32-36 years), comparing values with a normative life-course baboon cohort, 4-23 years...
January 30, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29444586/sex-differences-in-pericardial-adipose-tissue-assessed-by-pet-ct-and-association-with-cardiometabolic-risk
#14
Corey M Gill, Debora C Azevedo, Adriana L Oliveira, Edgar L Martinez-Salazar, Martin Torriani, Miriam A Bredella
Background Recent studies suggest that pericardial adipose tissue (PAT) is associated with whole body adiposity and insulin resistance. Moreover, the incidence of cardiovascular disease (CVD) differs between men and women. Although CVD is more prevalent in men, women suffering from CVD have a higher mortality compared to men. Differences in PAT may account for some of the observed sex differences in manifestations of CVD. Purpose To assess pericardial adipose tissue (PAT) as a biomarker for cardiometabolic risk and to assess potential sex differences...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29437161/associations-of-adult-genetic-risk-scores-for-adiposity-with-childhood-abdominal-liver-and-pericardial-fat-assessed-by-magnetic-resonance-imaging
#15
C Monnereau, S Santos, A van der Lugt, V W V Jaddoe, J F Felix
BACKGROUND: Genome-wide association studies (GWASs) identified single-nucleotide polymorphisms (SNPs) involved in adult fat distribution. Whether these SNPs also affect abdominal and organ-specific fat accumulation in children is unknown. METHODS: In a population-based prospective cohort study among 1995 children (median age: 9.8 years, 95% range 9.4-10.8), we tested the associations of six genetic risk scores based on previously identified SNPs for childhood body mass index (BMI), adult BMI, liver fat, waist-hip ratio, pericardial fat mass, visceral and subcutaneous adipose tissue ratio (VAT/SAT ratio) and four individual SAT- and VAT-associated SNPs for association with SAT (N=1746), VAT (N=1742), VAT/SAT ratio (N=1738), liver fat fraction (N=1950) and pericardial fat mass (N=1803) measured by magnetic resonance imaging...
December 7, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29375697/primary-chylopericardium-a-case-report-and-literature-review
#16
Xue Yu, Na Jia, Sanxia Ye, Min Zhou, Deping Liu
Primary chylopericardium (CP) is a rare clinical condition in which chylous fluid containing high concentrations of triglyceride accumulates in the pericardial cavity. The present study reports a case of CP that was successfully treated by reconstruction surgery of thoracic duct. To improve the ability to diagnosis and treat this rare disease, the current study also systematically extracted 104 reported cases of primary or idiopathic CP from the past 60 years (January 1950 to December of 2015), and reviewed the clinical manifestation, etiology, diagnosis and treatment of these cases...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29357096/associations-between-television-viewing-and-adiposity-among-south-asians
#17
Yichen Jin, Loretta DiPietro, Namratha R Kandula, Alka M Kanaya, Sameera A Talegawkar
OBJECTIVE: Sedentary behaviors related to television (TV) viewing are associated with adiposity; however, few investigations have focused on South Asians, an ethnicity particularly vulnerable to metabolic perturbations. This study examined the relationships between TV viewing and adiposity in a cohort of middle-aged and older South Asians. METHOD: Data were obtained from Mediators of Atherosclerosis in South Asians Living in America (MASALA) study (N = 906; mean age [standard deviation] = 55 [9...
January 22, 2018: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/29355561/ameliorating-effects-of-d-47-a-newly-developed-compound-on-lipid-metabolism-in-an-animal-model-of-familial-hypercholesterolemia-whhlmi-rabbits
#18
Shohei Tamura, Yui Koike, Hiroaki Takeda, Tomonari Koike, Yoshihiro Izumi, Ryosuke Nagasaka, Tetsuto Tsunoda, Motoo Tori, Kazuo Ogawa, Takeshi Bamba, Masashi Shiomi
Improvements induced in lipid metabolism in the liver by D-47, a newly developed compound, were examined herein. WHHLMI rabbits, an animal model of hypercholesterolemia and coronary atherosclerosis, was fed D-47-supplemented chow for 5 weeks at a dose of 30mg/kg. Lipid concentration were assayed using enzymatic methods. Plasma lipoproteins were fractionated with an ultracentrifuge. mRNA expression was analyzed with real-time PCR. Lipidome analyses of lipoproteins were performed using supercritical fluid chromatography mass spectrometry...
March 5, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29318960/the-role-of-inflammation-in-epicardial-adipose-tissue-in-heart-diseases
#19
Zdenek Matloch, Anna Cinkajzlova, Milos Mraze, Martin Haluzik
Epicardial adipose tissue is not only a specific adipose tissue depot but also an active endocrine organ producing numerous substances with an important role in the development of obesity-related heart diseases. It is located between myocardium and visceral pericardium and consists predominantly of adipocytes, immunocompetent cells, ganglia and interconnecting nerve branches. Several studies documented a positive correlation between pericardial and epicardial fat and left ventricular hypertrophy and septal thickening, leading to diastolic dysfunction, electrocardiographic abnormalities and facilitating cardiac failure...
January 9, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29301516/the-effect-of-dapagliflozin-treatment-on-epicardial-adipose-tissue-volume
#20
Takao Sato, Yoshifusa Aizawa, Sho Yuasa, Shohei Kishi, Koichi Fuse, Satoshi Fujita, Yoshio Ikeda, Hitoshi Kitazawa, Minoru Takahashi, Masahito Sato, Masaaki Okabe
BACKGROUND: Glycosuria produced by sodium-glucose co-transporter-2 (SGLT-2) inhibitors is associated with weight loss. SGLT-2 inhibitors reportedly might reduce the occurrence of cardiovascular events. Epicardial adipose tissue (EAT) is a pathogenic fat depot that may be associated with coronary atherosclerosis. The present study evaluated the relationship between an SGLT-2 inhibitor (dapagliflozin) and EAT volume. METHODS: In 40 diabetes mellitus patients with coronary artery disease (10 women and 30 men; mean age of all 40 patients was 67...
January 4, 2018: Cardiovascular Diabetology
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