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JOURNAL ARTICLE
M Aker, K Altenmüller, M Arenz, M Babutzka, J Barrett, S Bauer, M Beck, A Beglarian, J Behrens, T Bergmann, U Besserer, K Blaum, F Block, S Bobien, K Bokeloh, J Bonn, B Bornschein, L Bornschein, H Bouquet, T Brunst, T S Caldwell, L La Cascio, S Chilingaryan, W Choi, T J Corona, K Debowski, M Deffert, M Descher, P J Doe, O Dragoun, G Drexlin, J A Dunmore, S Dyba, F Edzards, L Eisenblätter, K Eitel, E Ellinger, R Engel, S Enomoto, M Erhard, D Eversheim, M Fedkevych, A Felden, S Fischer, B Flatt, J A Formaggio, F M Fränkle, G B Franklin, H Frankrone, F Friedel, D Fuchs, A Fulst, D Furse, K Gauda, H Gemmeke, W Gil, F Glück, S Görhardt, S Groh, S Grohmann, R Grössle, R Gumbsheimer, M Ha Minh, M Hackenjos, V Hannen, F Harms, J Hartmann, N Haußmann, F Heizmann, K Helbing, S Hickford, D Hilk, B Hillen, D Hillesheimer, D Hinz, T Höhn, B Holzapfel, S Holzmann, T Houdy, M A Howe, A Huber, T M James, A Jansen, A Kaboth, C Karl, O Kazachenko, J Kellerer, N Kernert, L Kippenbrock, M Kleesiek, M Klein, C Köhler, L Köllenberger, A Kopmann, M Korzeczek, A Kosmider, A Kovalík, B Krasch, M Kraus, H Krause, L Kuckert, B Kuffner, N Kunka, T Lasserre, T L Le, O Lebeda, M Leber, B Lehnert, J Letnev, F Leven, S Lichter, V M Lobashev, A Lokhov, M Machatschek, E Malcherek, K Müller, M Mark, A Marsteller, E L Martin, C Melzer, A Menshikov, S Mertens, L I Minter, S Mirz, B Monreal, P I Morales Guzmán, K Müller, U Naumann, W Ndeke, H Neumann, S Niemes, M Noe, N S Oblath, H-W Ortjohann, A Osipowicz, B Ostrick, E Otten, D S Parno, D G Phillips, P Plischke, A Pollithy, A W P Poon, J Pouryamout, M Prall, F Priester, M Röllig, C Röttele, P C-O Ranitzsch, O Rest, R Rinderspacher, R G H Robertson, C Rodenbeck, P Rohr, Ch Roll, S Rupp, M Ryšavý, R Sack, A Saenz, P Schäfer, L Schimpf, K Schlösser, M Schlösser, L Schlüter, H Schön, K Schönung, M Schrank, B Schulz, J Schwarz, H Seitz-Moskaliuk, W Seller, V Sibille, D Siegmann, A Skasyrskaya, M Slezák, A Špalek, F Spanier, M Steidl, N Steinbrink, M Sturm, M Suesser, M Sun, D Tcherniakhovski, H H Telle, T Thümmler, L A Thorne, N Titov, I Tkachev, N Trost, K Urban, D Vénos, K Valerius, B A VanDevender, R Vianden, A P Vizcaya Hernández, B L Wall, S Wüstling, M Weber, C Weinheimer, C Weiss, S Welte, J Wendel, K J Wierman, J F Wilkerson, J Wolf, W Xu, Y-R Yen, M Zacher, S Zadorozhny, M Zbořil, G Zeller
We report on the neutrino mass measurement result from the first four-week science run of the Karlsruhe Tritium Neutrino experiment KATRIN in spring 2019. Beta-decay electrons from a high-purity gaseous molecular tritium source are energy analyzed by a high-resolution MAC-E filter. A fit of the integrated electron spectrum over a narrow interval around the kinematic end point at 18.57 keV gives an effective neutrino mass square value of (-1.0_{-1.1}^{+0.9}) eV^{2}. From this, we derive an upper limit of 1...
November 29, 2019: Physical Review Letters
#22
COMPARATIVE STUDY
Tobias Storbeck, Nora Bruns, Christel Weiss, Ursula Felderhoff-Müser, Hanna Müller
The aim of this study was to correlate ventricular size and volumes of deep gray matter (DGM) in MRI at term equivalent age (TEA) with outcome at a corrected age of 24 months in preterm infants and with handedness. Seventy-three infants born before 32 weeks of gestation or with birth weight < 1500 g were included in this retrospective analysis and measurement of lateral ventricles, and DGM was performed on MRI scans. The left lateral ventricle was significantly larger than the right lateral ventricle (p = 0...
February 2020: European Journal of Pediatrics
#23
REVIEW
Charles Muller, Lindsay Matthews, Sonia S Kupfer, Jennifer M Weiss
PURPOSE OF REVIEW: Identification of Lynch syndrome is important from an individual patient and public health standpoint. As paradigms for Lynch syndrome diagnosis have shifted in recent years, this review will discuss rationale and limitations for current strategies as well as provide an overview of future directions in the field. RECENT FINDINGS: In recent years, the use of clinical criteria and risk scores for identification of Lynch syndrome has been augmented by universal testing of all newly diagnosed colorectal cancers with molecular methods to screen for mismatch repair deficiency with high sensitivity and specificity...
November 1, 2019: Current Treatment Options in Gastroenterology
#24
REVIEW
Werner Rühm, Joachim Breckow, Günter Dietze, Anna Friedl, Rüdiger Greinert, Peter Jacob, Stephan Kistinger, Rolf Michel, Wolfgang-Ulrich Müller, Heinz Otten, Christian Streffer, Wolfgang Weiss
This paper summarises the view of the German Commission on Radiological Protection ("Strahlenschutzkommission", SSK) on the rationale behind the currently valid dose limits and dose constraints for workers recommended by the International Commission on Radiological Protection (ICRP). The paper includes a discussion of the reasoning behind current dose limits followed by a discussion of the detriment used by ICRP as a measure for stochastic health effects. Studies on radiation-induced cancer are reviewed because this endpoint represents the most important contribution to detriment...
November 1, 2019: Radiation and Environmental Biophysics
#25
JOURNAL ARTICLE
Mohammad Golriz, Anastasia Lemekhova, Elias Khajeh, Omid Ghamarnejad, Mohammed Al-Saeedi, Oliver Strobel, Hackert Thilo, Beat Müller-Stich, Martin Schneider, Christoph Berchtold, Parham Tinoush, Philipp Mayer, De-Hua Chang, Karl Heinz Weiss, Katrin Hoffmann, Arianeb Mehrabi
INTRODUCTION: Liver resection is the only curative treatment for primary and secondary hepatic tumours. Improvements in perioperative preparation of patients and new surgical developments have made complex liver resections possible. However, small for size and flow syndrome (SFSF) is still a challenging issue, rendering patients inoperable and causing postoperative morbidity and mortality. Although the role of transhepatic flow in the postoperative outcome has been shown in small partial liver transplantation and experimental studies of SFSF, this has never been studied in the clinical setting following liver resection...
October 11, 2019: BMJ Open
#26
JOURNAL ARTICLE
Abdel-Salam Abdel-Aleem Ahmed, Mahmoud Ibrahim Kandil, Eslam Abdelshafi Tabl, Amr S Elgazzar
No abstract text is available yet for this article.
December 2019: Foot & Ankle International
#27
JOURNAL ARTICLE
Elise Chapiro, Elodie Pramil, M'boyba Diop, Damien Roos-Weil, Clémentine Dillard, Clémentine Gabillaud, Karim Maloum, Catherine Settegrana, Lucile Baseggio, Jean-François Lesesve, Mélanie Yon, Ludovic Jondreville, Claude Lesty, Frédéric Davi, Magali Le Garff-Tavernier, Nathalie Droin, Philippe Dessen, Caroline Algrin, Véronique Leblond, Jean Gabarre, Simon Bouzy, Virginie Eclache, Baptiste Gaillard, Evelyne Callet-Bauchu, Marc Muller, Christine Lefebvre, Nathalie Nadal, Antoine Ittel, Stéphanie Struski, Marie-Agnès Collonge-Rame, Benoit Quilichini, Sandra Fert-Ferrer, Nathalie Auger, Isabelle Radford-Weiss, Lena Wagner, Sebastian Scheinost, Thorsten Zenz, Santos A Susin, Olivier A Bernard, Florence Nguyen-Khac
B-cell prolymphocytic leukemia (B-PLL) is a rare hematological disorder whose underlying oncogenic mechanisms are poorly understood. Our cytogenetic and molecular assessments of 34 patients with B-PLL revealed several disease-specific features and potential therapeutic targets. The karyotype was complex (≥3 abnormalities) in 73% of the patients and highly complex (≥5 abnormalities) in 45%. The most frequent chromosomal aberrations were translocations involving MYC [t(MYC)] (62%), deletion (del)17p (38%), trisomy (tri)18 (30%), del13q (29%), tri3 (24%), tri12 (24%), and del8p (23%)...
November 21, 2019: Blood
#28
JOURNAL ARTICLE
Martijn L T M Müller, Uros Marusic, Miriam van Emde Boas, Daniel Weiss, Nicolaas I Bohnen
Introduction : Gait and balance disorders in Parkinson's disease (PD) represent a major therapeutic challenge as frequent falls and freezing of gait impair quality of life and predict mortality. Limited dopaminergic therapy responses implicate non-dopaminergic mechanisms calling for alternative therapies. Areas covered : The authors provide a review that encompasses pathophysiological changes involved in axial motor impairments in PD, pharmacological approaches, exercise, and physical therapy, improving physical activity levels, invasive and non-invasive neurostimulation, cueing interventions and wearable technology, and cognitive interventions...
December 2019: Expert Review of Neurotherapeutics
#29
JOURNAL ARTICLE
Abdel-Salam Abdel-Aleem Ahmed, Mahmoud Ibrahim Kandil, Eslam Abdelshafi Tabl
No abstract text is available yet for this article.
July 2019: Foot & Ankle International
#30
JOURNAL ARTICLE
Mark S Myerson
No abstract text is available yet for this article.
July 2019: Foot & Ankle International
#31
JOURNAL ARTICLE
Raymond Noordam, William J Young, Reem Salman, Jørgen K Kanters, Marten E van den Berg, Diana van Heemst, Henry J Lin, Sandhi Maria Barreto, Mary L Biggs, Ginevra Biino, Eulalia Catamo, Maria Pina Concas, Jun Ding, Daniel S Evans, Luisa Foco, Niels Grarup, Leo-Pekka Lyytikäinen, Massimo Mangino, Hao Mei, Peter J van der Most, Martina Müller-Nurasyid, Christopher P Nelson, Yong Qian, Linda Repetto, M Abdullah Said, Nabi Shah, Katharina Schramm, Pedro G Vidigal, Stefan Weiss, Jie Yao, Nuno R Zilhao, Jennifer A Brody, Peter S Braund, Marco Brumat, Eric Campana, Paraskevi Christofidou, Mark J Caulfield, Alessandro De Grandi, Anna F Dominiczak, Alex S F Doney, Gudny Eiriksdottir, Christina Ellervik, Luana Giatti, Martin Gögele, Claus Graff, Xiuqing Guo, Pim van der Harst, Peter K Joshi, Mika Kähönen, Bryan Kestenbaum, Maria F Lima-Costa, Allan Linneberg, Arie C Maan, Thomas Meitinger, Sandosh Padmanabhan, Cristian Pattaro, Annette Peters, Astrid Petersmann, Peter Sever, Mortiz F Sinner, Xia Shen, Alice Stanton, Konstantin Strauch, Elsayed Z Soliman, Kirill V Tarasov, Kent D Taylor, Chris H L Thio, André G Uitterlinden, Simona Vaccargiu, Melanie Waldenberger, Antonietta Robino, Adolfo Correa, Francesco Cucca, Steven R Cummings, Marcus Dörr, Giorgia Girotto, Vilmundur Gudnason, Torben Hansen, Susan R Heckbert, Christian R Juhl, Stefan Kääb, Terho Lehtimäki, Yongmei Liu, Paulo A Lotufo, Colin N A Palmer, Mario Pirastu, Peter P Pramstaller, Antonio Luiz P Ribeiro, Jerome I Rotter, Nilesh J Samani, Harold Snieder, Tim D Spector, Bruno H Stricker, Niek Verweij, James F Wilson, James G Wilson, J Wouter Jukema, Andrew Tinker, Christopher H Newton-Cheh, Nona Sotoodehnia, Dennis O Mook-Kanamori, Patricia B Munroe, Helen R Warren
BACKGROUND: Subclinical changes on the electrocardiogram are risk factors for cardiovascular mortality. Recognition and knowledge of electrolyte associations in cardiac electrophysiology are based on only in vitro models and observations in patients with severe medical conditions. OBJECTIVES: This study sought to investigate associations between serum electrolyte concentrations and changes in cardiac electrophysiology in the general population. METHODS: Summary results collected from 153,014 individuals (54...
June 25, 2019: Journal of the American College of Cardiology
#32
JOURNAL ARTICLE
Katharina Urdl, Stephanie Weiss, Günter Hesser, Andreas Kandelbauer, Edith Zikulnig-Rusch, Uwe Müller, Wolfgang Kern
The data present in this article affords insides in the characterization of a newly described bi-functional furan-melamine monomer, which is used for the production of monodisperse, furan-functionalized melamine-formaldehyde particles, as described in https://doi.org/10.1016/j.eurpolymj.2019.04.006 Urdl et al., 2019. In the related research article Urdl et al., 2019 data interpretations can be found. The furan-functionalization of particles is necessary to perform reversible Diels-Alder reactions with maleimide (BMI) crosslinker to form thermoreversible network systems...
August 2019: Data in Brief
#33
RANDOMIZED CONTROLLED TRIAL
Sven Dittrich, Erika Graf, Regina Trollmann, Ulrich Neudorf, Ulrike Schara, Antje Heilmann, Maja von der Hagen, Brigitte Stiller, Janbernd Kirschner, Robert Dalla Pozza, Wolfgang Müller-Felber, Katja Weiss, Katja von Au, Markus Khalil, Reinald Motz, Christoph Korenke, Martina Lange, Ekkehard Wilichowski, Joseph Pattathu, Friedrich Ebinger, Nicola Wiechmann, Rolf Schröder
BACKGROUND: X-linked Duchenne muscular dystrophy (DMD), the most frequent human hereditary skeletal muscle myopathy, inevitably leads to progressive dilated cardiomyopathy. We assessed the effect and safety of a combined treatment with the ACE-inhibitor enalapril and the β-blocker metoprolol in a German cohort of infantile and juvenile DMD patients with preserved left ventricular function. METHODS TRIAL DESIGN: Sixteen weeks single-arm open run-in therapy with enalapril and metoprolol followed by a two-arm 1:1 randomized double-blind placebo-controlled treatment in a multicenter setting...
May 10, 2019: Orphanet Journal of Rare Diseases
#34
JOURNAL ARTICLE
Marie-Claire Rassweiler-Seyfried, J J Rassweiler, C Weiss, M Müller, H P Meinzer, L Maier-Hein, J T Klein
PURPOSE: To compare iPad-assisted (Apple Inc., Cupertino, USA) percutaneous access to the kidney to the standard puncturing technique for percutaneous nephrolithotomy (PCNL). METHODS: For the iPad-assisted PCNL, a computed tomography is performed prior to surgery, using fiducial radiopaque markers. The important anatomical structures (i.e. kidney, stones) are segmented using specific software enabling the superimposition of images semi-transparently on the iPad by marker-based navigation...
May 9, 2019: World Journal of Urology
#35
JOURNAL ARTICLE
Katharina Petin, Ronald Weiss, Gerd Müller, Antje Garten, Anja Grahnert, Ulrich Sack, Sunna Hauschildt
Over the past few years the NAD-related compounds nicotinamide (NAM), nicotinamide riboside (NR) and 1-methylnicotinamide (MNA) have been established as important molecules in signalling pathways that contribute to metabolic functions of many cells, including those of the immune system. Among immune cells, monocytes/macrophages, which are the major players of inflammatory processes, are especially susceptible to the anti-inflammatory action of NAM. Here we asked whether NAM and the two other compounds have the potential to regulate differentiation and LPS-induced biological answers of the monocytic cell line THP-1...
July 2019: Innate Immunity
#36
JOURNAL ARTICLE
Gottfried J Palm, Lukas Reisky, Dominique Böttcher, Henrik Müller, Emil A P Michels, Miriam C Walczak, Leona Berndt, Manfred S Weiss, Uwe T Bornscheuer, Gert Weber
The extreme durability of polyethylene terephthalate (PET) debris has rendered it a long-term environmental burden. At the same time, current recycling efforts still lack sustainability. Two recently discovered bacterial enzymes that specifically degrade PET represent a promising solution. First, Ideonella sakaiensis PETase, a structurally well-characterized consensus α/β-hydrolase fold enzyme, converts PET to mono-(2-hydroxyethyl) terephthalate (MHET). MHETase, the second key enzyme, hydrolyzes MHET to the PET educts terephthalate and ethylene glycol...
April 12, 2019: Nature Communications
#37
REVIEW
Jan Lukas, Jola Pospech, Christina Oppermann, Christina Hund, Katharina Iwanov, Supansa Pantoom, Janine Petters, Moritz Frech, Susanne Seemann, Franziska-Gisela Thiel, Jana-Marielle Modenbach, Robert Bolsmann, Laura de Freitas Chama, Franziska Kraatz, Firas El-Hage, Manuel Gronbach, Annelie Klein, Regina Müller, Sabine Salloch, Frank-Ulrich Weiss, Peter Simon, Preshit Wagh, Almuth Klemenz, Elke Krüger, Julia Mayerle, Mihaela Delcea, Udo Kragl, Matthias Beller, Arndt Rolfs, Markus M Lerch, Matthias Sendler
The endoplasmic reticulum (ER) is the site of synthesis and folding of membrane and secretory proteins. The fraction of protein passing through the ER represents a large proportion of the total protein in the cell. Protein folding, glycosylation, sorting and transport are essential tasks of the ER and a compromised ER folding network has been recognized to be a key component in the disease pathogenicity of common neurodegenerative, metabolic and malignant diseases. On the other hand, the ER protein folding machinery also holds significant potential for therapeutic interventions...
April 9, 2019: Advances in Medical Sciences
#38
JOURNAL ARTICLE
Jingxia Wu, Sicong Ma, Roger Sandhoff, Yanan Ming, Agnes Hotz-Wagenblatt, Vincent Timmerman, Nathalie Bonello-Palot, Beate Schlotter-Weigel, Michaela Auer-Grumbach, Pavel Seeman, Wolfgang N Löscher, Markus Reindl, Florian Weiss, Eric Mah, Nina Weisshaar, Alaa Madi, Kerstin Mohr, Tilo Schlimbach, Rubí M-H Velasco Cárdenas, Jonas Koeppel, Florian Grünschläger, Lisann Müller, Maren Baumeister, Britta Brügger, Michael Schmitt, Guido Wabnitz, Yvonne Samstag, Guoliang Cui
Patients with the neurological disorder HSAN-I suffer frequent infections, attributed to a lack of pain sensation and failure to seek care for minor injuries. Whether protective CD8+ T cells are affected in HSAN-I patients remains unknown. Here, we report that HSAN-I-associated mutations in serine palmitoyltransferase subunit SPTLC2 dampened human T cell responses. Antigen stimulation and inflammation induced SPTLC2 expression, and murine T-cell-specific ablation of Sptlc2 impaired antiviral-T-cell expansion and effector function...
May 21, 2019: Immunity
#39
JOURNAL ARTICLE
Martina Gast, Bernhard H Rauch, Arash Haghikia, Shinichi Nakagawa, Jan Haas, Andrea Stroux, David Schmidt, Paul Schumann, Stefan Weiss, Lars Jensen, Adelheid Kratzer, Nicolle Kraenkel, Christian Müller, Daniela Börnigen, Tetsuro Hirose, Stefan Blankenberg, Felicitas Escher, Anja A Kühl, Andreas W Kuss, Benjamin Meder, Ulf Landmesser, Tanja Zeller, Wolfgang Poller
AIMS: Inflammation is a key driver of atherosclerosis and myocardial infarction (MI), and beyond proteins and microRNAs (miRs), long noncoding RNAs (lncRNAs) have been implicated in inflammation control. To obtain further information on the possible role of lncRNAs in the context of atherosclerosis, we obtained comprehensive transcriptome maps of circulating immune cells (peripheral blood mononuclear cells, PBMCs) of early onset MI patients. One lncRNA significantly suppressed in post-MI patients was further investigated in a murine knockout model...
November 1, 2019: Cardiovascular Research
#40
JOURNAL ARTICLE
Moritz Felcht, Claus-Detlev Klemke, Jan Peter Nicolay, Christel Weiss, Chalid Assaf, Marion Wobser, Max Schlaak, Uwe Hillen, Rose Moritz, Iliana Tantcheva-Poor, Dorothee Nashan, Marc Beyer, Edgar Dippel, Cornelia Sigrid Lissi Müller, Michael Max Sachse, Frank Meiss, Cyrill Géraud, Alexander Marx, Sergij Goerdt, Eva Geissinger, Werner Kempf
No abstract text is available yet for this article.
March 2019: Journal der Deutschen Dermatologischen Gesellschaft: JDDG
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