keyword
https://read.qxmd.com/read/33067140/association-of-clinical-factors-with-postoperative-complications-of-esophageal-atresia
#1
JOURNAL ARTICLE
Manuel Besendörfer, Hanna Müller, Christel Weiss, Alexandra Wagner, Vera Schellerer, André Hoerning, Sonja Diez
BACKGROUND: Esophageal atresia (EA) with or without tracheoesophageal fistula (TEF) remains one of the most common gastrointestinal neonatal malformations. Even though postoperative management is standardized, it differs between hospitals and disease-associated clinical factors that may play a role in outcome have not yet been assessed in detail. METHODS: In this monocentric retrospective study, data of 43 patients with EA between 2010 and 2018 were analyzed. Analysis includes assessment of the clinical background, surgical technique, postoperative management including application of continuous muscle relaxation (CMR), influence of coagulation parameters such as factor XIII and incidence of complications...
January 2021: Pediatrics and Neonatology
https://read.qxmd.com/read/32859049/quantitative-long-term-monitoring-of-the-circulating-gases-in-the-katrin-experiment-using-raman-spectroscopy
#2
JOURNAL ARTICLE
Max Aker, Konrad Altenmüller, Armen Beglarian, Jan Behrens, Anatoly Berlev, Uwe Besserer, Benedikt Bieringer, Klaus Blaum, Fabian Block, Beate Bornschein, Lutz Bornschein, Matthias Böttcher, Tim Brunst, Thomas C Caldwell, Suren Chilingaryan, Wonqook Choi, Deseada D Díaz Barrero, Karol Debowski, Marco Deffert, Martin Descher, Peter J Doe, Otokar Dragoun, Guido Drexlin, Stephan Dyba, Frank Edzards, Klaus Eitel, Enrico Ellinger, Ralph Engel, Sanshiro Enomoto, Mariia Fedkevych, Arne Felden, Joseph F Formaggio, Florian Fränkle, Gregg B Franklin, Fabian Friedel, Alexander Fulst, Kevin Gauda, Woosik Gil, Ferenc Glück, Robin Größle, Rainer Gumbsheimer, Volker Hannen, Norman Haußmann, Klaus Helbing, Stephanie Hickford, Roman Hiller, David Hillesheimer, Dominic Hinz, Thomas Höhn, Thibaut Houdy, Anton Huber, Alexander Jansen, Christian Karl, Jonas Kellerer, Luke Kippenbrock, Manuel Klein, Christoph Köhler, Leonard Köllenberger, Andreas Kopmann, Marc Korzeczek, Alojz Kovalík, Bennet Krasch, Holger Krause, Luisa La Cascio, Thierry Lasserre, Thanh-Long Le, Ondřej Lebeda, Bjoern Lehnert, Alexey Lokhov, Moritz Machatschek, Emma Malcherek, Alexander Marsteller, Eric L Martin, Matthias Meier, Christin Melzer, Susanne Mertens, Klaus Müller, Simon Niemes, Patrick Oelpmann, Alexander Osipowicz, Diana S Parno, Alan W P Poon, Jose M Lopez Poyato, Florian Priester, Oliver Rest, Marco Röllig, Carsten Röttele, R G Hamish Robertson, Caroline Rodenbeck, Milos Ryšavỳ, Rudolf Sack, Alejandro Saenz, Peter Schäfer, Anna Schaller Née Pollithy, Lutz Schimpf, Klaus Schlösser, Magnus Schlösser, Lisa Schlüter, Michael Schrank, Bruno Schulz, Michal Sefčík, Hendrik Seitz-Moskaliuk, Valérian Sibille, Daniel Siegmann, Martin Slezák, Felix Spanier, Markus Steidl, Michael Sturm, Menglei Sun, Helmut H Telle, Larisa A Thorne, Thomas Thümmler, Nikita Titov, Igor Tkachev, Drahoš Vénos, Kathrin Valerius, Ana P Vizcaya Hernández, Marc Weber, Christian Weinheimer, Christiane Weiss, Stefan Welte, Jürgen Wendel, John F Wilkerson, Joachim Wolf, Sascha Wüstling, Weiran Xu, Yung-Ruey Yen, Sergey Zadoroghny, Genrich Zeller
The Karlsruhe Tritium Neutrino (KATRIN) experiment aims at measuring the effective electron neutrino mass with a sensitivity of 0.2 eV/c2 , i.e., improving on previous measurements by an order of magnitude. Neutrino mass data taking with KATRIN commenced in early 2019, and after only a few weeks of data recording, analysis of these data showed the success of KATRIN, improving on the known neutrino mass limit by a factor of about two. This success very much could be ascribed to the fact that most of the system components met, or even surpassed, the required specifications during long-term operation...
August 26, 2020: Sensors
https://read.qxmd.com/read/32816960/discrimination-of-small-sugar-concentration-differences-helps-the-nectar-feeding-bat-leptonycteris-yerbabuenae-cover-energetic-demands
#3
JOURNAL ARTICLE
Michael H Walter, Aaron Verdong, Vanessa Olmos, Christina C Weiss, Lisa-Ruth Vial, Ahilan Putra, Jan Müller, Marco Tschapka, Hans-Ulrich Schnitzler
Every day nectar-feeding animals face an energetic challenge during foraging: they must locate and select flowers that provide nectar with adequate amounts of sugar to cover their very high energy needs. To understand this decision-making process, it is crucial to know how accurately sugar concentration differences can be discriminated. In a controlled laboratory setting, we offered the nectar-specialist bat Leptonycteris yerbabuenae the choice between different sugar solutions covering the entire concentration range of bat-pollinated plants (3-33%)...
September 23, 2020: Journal of Experimental Biology
https://read.qxmd.com/read/32805503/ultraviolet-b-radiation-affects-epithelial-cell-morphology-and-ultrastructure-in-the-hepatopancreas-of-the-freshwater-decapod-macrobrachium-olfersii
#4
JOURNAL ARTICLE
Yara Maria Rauh Müller, Madson Silveira de Melo, Valquíria Machado Cardoso Weiss, Thaline de Quadros, Dib Ammar, Evelise Maria Nazari
The hepatopancreas is the digestive organ of crustaceans, and plays important roles also in the synthesis and secretion of sexual hormones, immunological defenses and xenobiotic detoxification. Although the importance of this organ in crustaceans cannot be underestimated, the effects of ultraviolet B (UVB) radiation on hepatopancreas are poorly understood. Moreover, Macrobrachium prawns, have a transparent carapace, which make them more susceptible to UVB radiation, since their internal organs, such as hepatopancreas, are easily reached by solar radiation...
November 2020: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/32770804/dmbt1-is-upregulated-in-lung-epithelial-cells-after-hypoxia-and-changes-surfactant-ultrastructure
#5
JOURNAL ARTICLE
Hanna Müller, Andreas Schmiedl, Christel Weiss, Maria Ai, Susan Jung, Marcus Renner
BACKGROUND: Hypoxia and asphyxia are known to induce surfactant inactivation in newborns. Deleted in Malignant Brain Tumors 1 (DMBT1) is an innate immunity protein with functions in epithelial differentiation and angiogenesis. It was detected in hyaline membranes of infants with respiratory distress syndrome. Human recombinant DMBT1 is able to increase the surface tension of exogenous surfactant preparations in a dose-dependent manner. METHODS: Immunohistochemistry was performed on lung sections of infants who died due to pre-, peri- or postnatal hypoxia...
November 2020: Pediatric Pulmonology
https://read.qxmd.com/read/32743490/serum-igg4-levels-outperform-igg4-igg-rna-ratio-in-differential-diagnosis-of-igg4-related-disease
#6
JOURNAL ARTICLE
Lucas A Schulte, Frank Arnold, Florian Siegel, Johanna Backhus, Georg Beyer, Frank Ulrich Weiss, Lukas Perkhofer, Alica Beutel, Thomas Seufferlein, Martin Müller, Alexander Kleger
No abstract text is available yet for this article.
August 2020: JHEP reports: innovation in hepatology
https://read.qxmd.com/read/32694140/evolutionary-stabilization-of-cooperative-toxin-production-through-a-bacterium-plasmid-phage-interplay
#7
JOURNAL ARTICLE
Stefanie Spriewald, Eva Stadler, Burkhard A Hense, Philipp C Münch, Alice C McHardy, Anna S Weiss, Nancy Obeng, Johannes Müller, Bärbel Stecher
Colicins are toxins produced and released by Enterobacteriaceae to kill competitors in the gut. While group A colicins employ a division of labor strategy to liberate the toxin into the environment via colicin-specific lysis, group B colicin systems lack cognate lysis genes. In Salmonella enterica serovar Typhimurium ( S. Tm), the group B colicin Ib (ColIb) is released by temperate phage-mediated bacteriolysis. Phage-mediated ColIb release promotes S. Tm fitness against competing Escherichia coli It remained unclear how prophage-mediated lysis is realized in a clonal population of ColIb producers and if prophages contribute to evolutionary stability of toxin release in S...
July 21, 2020: MBio
https://read.qxmd.com/read/32693025/de-novo-variants-in-the-atpase-module-of-morc2-cause-a-neurodevelopmental-disorder-with-growth-retardation-and-variable-craniofacial-dysmorphism
#8
JOURNAL ARTICLE
Maria J Guillen Sacoto, Iva A Tchasovnikarova, Erin Torti, Cara Forster, E Hallie Andrew, Irina Anselm, Kristin W Baranano, Lauren C Briere, Julie S Cohen, William J Craigen, Cheryl Cytrynbaum, Nina Ekhilevitch, Matthew J Elrick, Ali Fatemi, Jamie L Fraser, Renata C Gallagher, Andrea Guerin, Devon Haynes, Frances A High, Cara N Inglese, Courtney Kiss, Mary Kay Koenig, Joel Krier, Kristin Lindstrom, Michael Marble, Hannah Meddaugh, Ellen S Moran, Chantal F Morel, Weiyi Mu, Eric A Muller, Jessica Nance, Marvin R Natowicz, Adam L Numis, Bridget Ostrem, John Pappas, Carl E Stafstrom, Haley Streff, David A Sweetser, Marta Szybowska, Melissa A Walker, Wei Wang, Karin Weiss, Rosanna Weksberg, Patricia G Wheeler, Grace Yoon, Robert E Kingston, Jane Juusola
MORC2 encodes an ATPase that plays a role in chromatin remodeling, DNA repair, and transcriptional regulation. Heterozygous variants in MORC2 have been reported in individuals with autosomal-dominant Charcot-Marie-Tooth disease type 2Z and spinal muscular atrophy, and the onset of symptoms ranges from infancy to the second decade of life. Here, we present a cohort of 20 individuals referred for exome sequencing who harbor pathogenic variants in the ATPase module of MORC2. Individuals presented with a similar phenotype consisting of developmental delay, intellectual disability, growth retardation, microcephaly, and variable craniofacial dysmorphism...
August 6, 2020: American Journal of Human Genetics
https://read.qxmd.com/read/32613353/evaluating-the-didactic-value-of-3d-visualization-in-otosurgery
#9
JOURNAL ARTICLE
Nora M Weiss, Armin Schneider, John M Hempel, Florian C Uecker, Sara M van Bonn, Sebastian P Schraven, Stefanie Rettschlag, Tobias Schuldt, Joachim Müller, Stefan K Plontke, Robert Mlynski
INTRODUCTION: Improvements of surgical visualization add value to the quality of clinical routine and offer the opportunity to improve surgical education of medical staff. The aim of this study was to determine whether otorhinolaryngology trainees gain additional comprehension of the anatomical structures and the surgical site when 3D visualization is used. METHODS: Data were collected from ENT trainees of microsurgical courses of the middle ear, inner ear and lateral skull base at four university ENT departments (Charité (Berlin), Martin Luther University Halle-Wittenberg (Halle/Saale), Ludwig Maximilian University (Munich) and Rostock University Medical Center)...
April 2021: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/32600969/radiographic-analysis-of-m%C3%A3-ller-weiss-disease
#10
JOURNAL ARTICLE
John Wong-Chung, Raymond McKenna, Adam Tucker, Desmond Gibson, Pallab Datta
BACKGROUND: The only classification of Müller-Weiss disease (MWD) is based primarily on Méary's talo-first metatarsal angle. It describes increasing sag of the medial longitudinal arch with greater degrees of compression and fragmentation of the navicular. Purportedly, the talar head pushes the subtalar joint into varus and drives the medial pole of the navicular medially, as it protrudes inferiorly and laterally. Its authors stipulated heel varus as a pre-requisite, coining the term 'paradoxical pes planus varus' to define heel varus and flatfoot as hallmark deformities of the condition...
July 2021: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://read.qxmd.com/read/32582588/clinical-characteristics-of-necrotizing-enterocolitis-in-preterm-patients-with-and-without-persistent-ductus-arteriosus-and-in-patients-with-congenital-heart-disease
#11
JOURNAL ARTICLE
Sonja Diez, Lea Tielesch, Christel Weiss, Julia Halbfass, Hanna Müller, Manuel Besendörfer
Background: Diagnosis and management of NEC is based on clinical, radiological, and laboratory findings. Discrimination of pathogens for an improved understanding of NEC in preterm infants and NEC in infants with congenital heart disease has been previously discussed and enables evaluation of further NEC biomarkers. Patients and Methods: Within a study period of 11 years (2008-2019), we identified 107 patients with a diagnosis of NEC at our primary care center. Thirty-six out of 54 patients suffering from NEC in high Bell stages who underwent surgery met inclusion criteria...
2020: Frontiers in Pediatrics
https://read.qxmd.com/read/32456170/acute-effects-of-a-short-bout-of-physical-activity-on-cognitive-function-in-sport-students
#12
RANDOMIZED CONTROLLED TRIAL
Martin Niedermeier, Elisabeth M Weiss, Lisa Steidl-Müller, Martin Burtscher, Martin Kopp
Physical activity is a promising intervention to restore cognitive function after prolonged sedentary periods. However, little is known about the effect of short physical activity bouts on cognition especially among individuals that are used to physical activity. Therefore, the goal of the present study was to assess the impact of a single ten-minute physical activity bout on the cognitive domain of visual attention compared to sedentary behavior in a population of physically active sport students. Using a randomized controlled design, 51 healthy and physically active sport students [mean age: 22...
May 23, 2020: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/32454277/furan-fatty-acids-in-enriched-%C3%AF-3-fish-oil-oxidation-kinetics-with-and-without-added-monomethyl-furan-fatty-acid-as-potential-natural-antioxidant
#13
JOURNAL ARTICLE
Monise Helen Masuchi Buscato, Franziska Müller, Walter Vetter, Jochen Weiss, Hanna Salminen
This study investigated the lipid oxidation reactions of furan fatty acids, long-chain ω-3 polyunsaturated fatty acids, and tocopherols in an enriched ω-3 fish oil to better understand their degradation kinetics. Furthermore, the influence of an added monomethyl furan fatty acid 9-(3-methyl-5-pentylfuran-2-yl) nonanoic acid (9M5) at 50-250 µM on the oxidation reactions was evaluated. The results showed that the fish oil was rich in monomethyl and dimethyl furan fatty acids (c = 1.3 g/100 g lipids). Upon oxidation of the fish oil, the dimethyl furan fatty acids degraded faster than the monomethyl ones, but also faster than tocopherols...
October 15, 2020: Food Chemistry
https://read.qxmd.com/read/32439900/multi-ancestry-gwas-of-the-electrocardiographic-pr-interval-identifies-202-loci-underlying-cardiac-conduction
#14
JOURNAL ARTICLE
Ioanna Ntalla, Lu-Chen Weng, James H Cartwright, Amelia Weber Hall, Gardar Sveinbjornsson, Nathan R Tucker, Seung Hoan Choi, Mark D Chaffin, Carolina Roselli, Michael R Barnes, Borbala Mifsud, Helen R Warren, Caroline Hayward, Jonathan Marten, James J Cranley, Maria Pina Concas, Paolo Gasparini, Thibaud Boutin, Ivana Kolcic, Ozren Polasek, Igor Rudan, Nathalia M Araujo, Maria Fernanda Lima-Costa, Antonio Luiz P Ribeiro, Renan P Souza, Eduardo Tarazona-Santos, Vilmantas Giedraitis, Erik Ingelsson, Anubha Mahajan, Andrew P Morris, Fabiola Del Greco M, Luisa Foco, Martin Gögele, Andrew A Hicks, James P Cook, Lars Lind, Cecilia M Lindgren, Johan Sundström, Christopher P Nelson, Muhammad B Riaz, Nilesh J Samani, Gianfranco Sinagra, Sheila Ulivi, Mika Kähönen, Pashupati P Mishra, Nina Mononen, Kjell Nikus, Mark J Caulfield, Anna Dominiczak, Sandosh Padmanabhan, May E Montasser, Jeff R O'Connell, Kathleen Ryan, Alan R Shuldiner, Stefanie Aeschbacher, David Conen, Lorenz Risch, Sébastien Thériault, Nina Hutri-Kähönen, Terho Lehtimäki, Leo-Pekka Lyytikäinen, Olli T Raitakari, Catriona L K Barnes, Harry Campbell, Peter K Joshi, James F Wilson, Aaron Isaacs, Jan A Kors, Cornelia M van Duijn, Paul L Huang, Vilmundur Gudnason, Tamara B Harris, Lenore J Launer, Albert V Smith, Erwin P Bottinger, Ruth J F Loos, Girish N Nadkarni, Michael H Preuss, Adolfo Correa, Hao Mei, James Wilson, Thomas Meitinger, Martina Müller-Nurasyid, Annette Peters, Melanie Waldenberger, Massimo Mangino, Timothy D Spector, Michiel Rienstra, Yordi J van de Vegte, Pim van der Harst, Niek Verweij, Stefan Kääb, Katharina Schramm, Moritz F Sinner, Konstantin Strauch, Michael J Cutler, Diane Fatkin, Barry London, Morten Olesen, Dan M Roden, M Benjamin Shoemaker, J Gustav Smith, Mary L Biggs, Joshua C Bis, Jennifer A Brody, Bruce M Psaty, Kenneth Rice, Nona Sotoodehnia, Alessandro De Grandi, Christian Fuchsberger, Cristian Pattaro, Peter P Pramstaller, Ian Ford, J Wouter Jukema, Peter W Macfarlane, Stella Trompet, Marcus Dörr, Stephan B Felix, Uwe Völker, Stefan Weiss, Aki S Havulinna, Antti Jula, Katri Sääksjärvi, Veikko Salomaa, Xiuqing Guo, Susan R Heckbert, Henry J Lin, Jerome I Rotter, Kent D Taylor, Jie Yao, Renée de Mutsert, Arie C Maan, Dennis O Mook-Kanamori, Raymond Noordam, Francesco Cucca, Jun Ding, Edward G Lakatta, Yong Qian, Kirill V Tarasov, Daniel Levy, Honghuang Lin, Christopher H Newton-Cheh, Kathryn L Lunetta, Alison D Murray, David J Porteous, Blair H Smith, Bruno H Stricker, André Uitterlinden, Marten E van den Berg, Jeffrey Haessler, Rebecca D Jackson, Charles Kooperberg, Ulrike Peters, Alexander P Reiner, Eric A Whitsel, Alvaro Alonso, Dan E Arking, Eric Boerwinkle, Georg B Ehret, Elsayed Z Soliman, Christy L Avery, Stephanie M Gogarten, Kathleen F Kerr, Cathy C Laurie, Amanda A Seyerle, Adrienne Stilp, Solmaz Assa, M Abdullah Said, M Yldau van der Ende, Pier D Lambiase, Michele Orini, Julia Ramirez, Stefan Van Duijvenboden, David O Arnar, Daniel F Gudbjartsson, Hilma Holm, Patrick Sulem, Gudmar Thorleifsson, Rosa B Thorolfsdottir, Unnur Thorsteinsdottir, Emelia J Benjamin, Andrew Tinker, Kari Stefansson, Patrick T Ellinor, Yalda Jamshidi, Steven A Lubitz, Patricia B Munroe
The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a multi-ancestry (N = 293,051) genome-wide association meta-analysis for the PR interval, discovering 202 loci of which 141 have not previously been reported. Variants at identified loci increase the percentage of heritability explained, from 33.5% to 62.6%. We observe enrichment for cardiac muscle developmental/contractile and cytoskeletal genes, highlighting key regulation processes for atrioventricular conduction...
May 21, 2020: Nature Communications
https://read.qxmd.com/read/32397762/covid-19-global-pandemic-planning-decontamination-and-reuse-processes-for-n95-respirators
#15
JOURNAL ARTICLE
Douglas J Perkins, Steven Villescas, Terry H Wu, Timothy Muller, Steven Bradfute, Ivy Hurwitz, Qiuying Cheng, Hannah Wilcox, Myissa Weiss, Chris Bartlett, Jens Langsjoen, Phil Seidenberg
There is a critical shortage of personal protective equipment (PPE) around the globe. This article describes the safe collection, storage, and decontamination of N95 respirators using hydrogen peroxide vapor (HPV). This article is unique because it describes the HPV process in an operating room, and is therefore, a deployable method for many healthcare settings. Results presented here offer creative solutions to the current PPE shortage.
June 2020: Experimental Biology and Medicine
https://read.qxmd.com/read/32278744/postnatal-serum-creatinine-is-elevated-in-preterm-infants-with-pprom-induced-anhydramnios
#16
JOURNAL ARTICLE
Nora Bruns, Ann-Christin Stähling, Sandra Greve, Christel Weiss, Angela Köninger, Ursula Felderhoff-Müser, Hanna Müller
BACKGROUND: The reason for increased serum creatinine levels in preterm infants often remains unclear. We aimed to determine whether postnatal serum creatinine in preterm infants correlates with intake of amniotic fluid, represented by the amount of amniotic fluid after preterm premature rupture of membranes (PPROM). METHODS: 74 preterm infants with PPROM > 48 h duration were retrospectively studied. Postnatal creatinine concentration was determined at day 2-5, 10-17 and 26-33 of life and compared between infants with normal intrauterine amniotic volumes, oligohydramnios and anhydramnios...
August 2020: Pediatrics and Neonatology
https://read.qxmd.com/read/32267102/impact-of-simultaneous-subthalamic-and-nigral-stimulation-on-dysphagia-in-parkinson-s-disease
#17
RANDOMIZED CONTROLLED TRIAL
Christina Pflug, Julie C Nienstedt, Alessandro Gulberti, Frank Müller, Eik Vettorazzi, Jana-Christiane Koseki, Almut Niessen, Till Flügel, Ute Hidding, Carsten Buhmann, Daniel Weiss, Christian Gerloff, Wolfgang Hamel, Christian K E Moll, Monika Pötter-Nerger
OBJECTIVES: Dysphagia is a frequent and highly relevant symptom in Parkinson's disease (PD) due to high associated morbidity and mortality. To compare the effect of simultaneous stimulation of the subthalamic nucleus (STN) and substantia nigra (SNr) with conventional STN-stimulation on swallowing function in Parkinson's disease. METHODS: In this controlled, randomized, double-blind, cross-over clinical trial, 15 PD patients were assessed with DBS switched off (STIM OFF), STN-DBS, STN + SNr-DBS...
May 2020: Annals of Clinical and Translational Neurology
https://read.qxmd.com/read/32041837/clonal-zeb1-driven-mesenchymal-transition-promotes-targetable-oncologic-antiangiogenic-therapy-resistance
#18
JOURNAL ARTICLE
Ankush Chandra, Arman Jahangiri, William Chen, Alan T Nguyen, Garima Yagnik, Matheus P Pereira, Saket Jain, Joseph H Garcia, Sumedh S Shah, Harsh Wadhwa, Rushikesh S Joshi, Jacob Weiss, Kayla J Wolf, Jung-Ming G Lin, Sören Müller, Jonathan W Rick, Aaron A Diaz, Luke A Gilbert, Sanjay Kumar, Manish K Aghi
Glioblastoma (GBM) responses to bevacizumab are invariably transient with acquired resistance. We profiled paired patient specimens and bevacizumab-resistant xenograft models pre- and post-resistance toward the primary goal of identifying regulators whose targeting could prolong the therapeutic window, and the secondary goal of identifying biomarkers of therapeutic window closure. Bevacizumab-resistant patient specimens and xenografts exhibited decreased vessel density and increased hypoxia versus pre-resistance, suggesting that resistance occurs despite effective therapeutic devascularization...
April 1, 2020: Cancer Research
https://read.qxmd.com/read/31907357/bcl-xl-expression-is-essential-for-human-erythropoiesis-and-engraftment-of-hematopoietic-stem-cells
#19
JOURNAL ARTICLE
Sehar Afreen, Sheila Bohler, Alexandra Müller, Eva-Maria Demmerath, Julia Miriam Weiss, Jonas Samuel Jutzi, Kristina Schachtrup, Mirjam Kunze, Miriam Erlacher
The anti-apoptotic BCL-2 proteins (BCL-2, BCL-XL, MCL-1, A1, BCL-W) counteract apoptotic signals emerging during development and under stress conditions, and are thus essential for the survival of every cell. While the "BCL-2 addiction" of different cell types is well described in mouse models, there is only limited information available on the role of different anti-apoptotic BCL-2 proteins in a given human cell type. Here we characterize the role of BCL-XL for survival and function of human hematopoietic cells, with the aim to predict hematological side effects of novel BCL-XL-inhibiting BH3-mimetics and to identify hematological malignancies potentially responsive to such inhibitors...
January 6, 2020: Cell Death & Disease
https://read.qxmd.com/read/31876626/magnetic-resonance-kidney-parenchyma-t2-as-a-novel-imaging-biomarker-for-autosomal-dominant-polycystic-kidney-disease
#20
JOURNAL ARTICLE
Florian Siedek, Franziska Grundmann, Kilian Weiss, Daniel Pinto Dos Santos, Sita Arjune, Stefan Haneder, Thorsten Persigehl, Roman-Ulrich Müller, Bettina Baessler
OBJECTIVE: Autosomal dominant polycystic kidney disease (ADPKD) is a chronic progressive disorder with a significant disease burden leading to end-stage renal disease in more than 75% of the affected individuals. Although prediction of disease progression is highly important, all currently available biomarkers-including height-adjusted total kidney volume (htTKV)-have important drawbacks in the everyday clinical setting. Thus, the purpose of this study was to evaluate T2 mapping as a source of easily obtainable and accurate biomarkers, which are needed for improved patient counseling and selection of targeted treatment options...
April 2020: Investigative Radiology
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