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https://www.readbyqxmd.com/read/28931070/atrazine-induced-epigenetic-transgenerational-inheritance-of-disease-lean-phenotype-and-sperm-epimutation-pathology-biomarkers
#1
Margaux McBirney, Stephanie E King, Michelle Pappalardo, Elizabeth Houser, Margaret Unkefer, Eric Nilsson, Ingrid Sadler-Riggleman, Daniel Beck, Paul Winchester, Michael K Skinner
Ancestral environmental exposures to a variety of environmental toxicants and other factors have been shown to promote the epigenetic transgenerational inheritance of adult onset disease. The current study examined the potential transgenerational actions of the herbicide atrazine. Atrazine is one of the most commonly used herbicides in the agricultural industry, in particular with corn and soy crops. Outbred gestating female rats were transiently exposed to a vehicle control or atrazine. The F1 generation offspring were bred to generate the F2 generation and then the F2 generation bred to generate the F3 generation...
2017: PloS One
https://www.readbyqxmd.com/read/28931022/examining-accident-reports-involving-autonomous-vehicles-in-california
#2
Francesca M Favarò, Nazanin Nader, Sky O Eurich, Michelle Tripp, Naresh Varadaraju
Autonomous Vehicle technology is quickly expanding its market and has found in Silicon Valley, California, a strong foothold for preliminary testing on public roads. In an effort to promote safety and transparency to consumers, the California Department of Motor Vehicles has mandated that reports of accidents involving autonomous vehicles be drafted and made available to the public. The present work shows an in-depth analysis of the accident reports filed by different manufacturers that are testing autonomous vehicles in California (testing data from September 2014 to March 2017)...
2017: PloS One
https://www.readbyqxmd.com/read/28930954/acute-procedural-interventions-after-pediatric-blunt-abdominal-trauma-a-prospective-multicenter-evaluation
#3
Chase A Arbra, Adam M Vogel, Jingwen Zhang, Patrick D Mauldin, Eunice Y Huang, Kate B Savoie, Matthew T Santore, KuoJen Tsao, Tiffany G Ostovar-Kermani, Richard A Falcone, M Sidney Dassinger, John Recicar, Jeffrey H Haynes, Martin L Blakely, Robert T Russell, Bindi J Naik-Mathuria, Shawn D St Peter, David P Mooney, Chinwendu Onwubiko, Jeffrey S Upperman, Christian J Streck
BACKGROUND: Pediatric intra-abdominal injuries (IAI) from blunt abdominal trauma (BAT) rarely require emergent intervention. For those children undergoing procedural intervention, our aim was to understand the timing and indications for operation and angiographic embolization. METHODS: We prospectively enrolled children younger than 16 years after BAT at 14 Level I Pediatric Trauma Centers over a 1-year period. Patients with IAI who received an intervention (IAI-I) were compared with those who did not receive an intervention using descriptive statistics and univariate analysis; p less than 0...
October 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28930945/effects-of-propranolol-and-clonidine-on-brain-edema-blood-brain-barrier-permeability-and-endothelial-glycocalyx-disruption-following-fluid-percussion-brain-injury-in-the-rat
#4
Gustav Folmer Genét, Peter Bentzer, Morten Bagge Hansen, Sisse Rye Ostrowski, Pär Ingemar Johansson
BACKGROUND: Traumatic brain injury causes a disruption of the vascular endothelial glycocalyx layer that is associated with an overactivation of the sympathoadrenal system. We hypothesized that early and unselective beta-blockade with propranolol alone or in combination with the alfa2-agonist clonidine would decrease brain edema, blood-brain-barrier permeability and glycocalyx disruption at 24 hours after trauma. METHODS: We subjected fifty-three adult male Sprague-Dawley rats to lateral fluid-percussion brain injury and randomized infusion with propranolol (n=16), propranolol+clonidine (n=16), vehicle (n=16) or sham (n=5) for 24 hours...
September 20, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28930799/characterizing-the-interrelationships-of-prescription-opioid-and-benzodiazepine-drugs-with-worker-health-and-workplace-hazards
#5
Michele Kowalski-McGraw, Judith Green-McKenzie, Sudha P Pandalai, Paul A Schulte
OBJECTIVE: Prescription opioid and benzodiazepine drug use, which has risen significantly, can affect worker health. Exploration of the scientific literature assessed (1) interrelationships of such drug use, occupational risk factors, and illness and injury, and (2) occupational and personal risk factor combinations that can affect their use. METHODS: The scientific literature from 2000 to 2015 was searched to determine any interrelationships. RESULTS: Evidence for eight conceptual models emerged based on the search yield of 133 articles...
September 19, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28929913/development-of-acute-promyelocytic-leukemia-in-a-patient-with-tetraplegia-while-in-inpatient-rehabilitation-a-case-report
#6
Christopher A Beal, Michael C Krouse, Jeffrey T Tubbs
STUDY DESIGN: a single case report. OBJECTIVES: To report a case of a patient with tetraplegia who developed acute promyelocytic leukemia (APL) while in inpatient rehabilitation after 10.5 months. SETTING: A VA Medical Center Spinal Cord Injury Service and Disorders Unit Case Report: A 47 year-old male with a stage IV sacral pressure ulcer and C4 AIS A complete tetraplegia secondary to a motor vehicle collision, developed fever, thrombocytopenia, and anemia 20 months after his injury while in inpatient rehabilitation and was found to have APL, confirmed following bone marrow biopsy...
September 20, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28928676/effects-of-immune-activation-during-early-or-late-gestation-on-n-methyl-d-aspartate-receptor-measures-in-adult-rat-offspring
#7
Tasnim Rahman, Katerina Zavitsanou, Tertia Purves-Tyson, Lauren R Harms, Crystal Meehan, Ulrich Schall, Juanita Todd, Deborah M Hodgson, Patricia T Michie, Cyndi Shannon Weickert
BACKGROUND: Glutamatergic receptor [N-methyl-d-aspartate receptor (NMDAR)] alterations within cortex, hippocampus, and striatum are linked to schizophrenia pathology. Maternal immune activation (MIA) is an environmental risk factor for the development of schizophrenia in offspring. In rodents, gestational timing of MIA may result in distinct behavioral outcomes in adulthood, but how timing of MIA may impact the nature and extent of NMDAR-related changes in brain is not known. We hypothesize that NMDAR-related molecular changes in rat cortex, striatum, and hippocampus are induced by MIA and are dependent on the timing of gestational inflammation and sex of the offspring...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28928002/association-between-seatbelt-sign-and-internal-injuries-in-the-contemporary-airbag-era-a-retrospective-cohort-study
#8
Julie M Glover, Madelyn F Waychoff, Monica Casmaer, Michael D April, Curtis J Hunter, Scott T Trexler, Lorne H Blackbourne
BACKGROUND: Literature predating routine availability of airbags reported an association between seatbelt signs and internal injuries. We measured this association among patients involved in motor vehicle crashes (MVCs) with airbag deployment. METHODS: We conducted a retrospective cohort study by chart review of all MVC patients presenting to our Emergency Department (ED) during 1 January 2008-30 September 2015. We included all adult MVC patients in the driver or front passenger seats with both shoulder and lap seatbelts and airbag deployment...
September 12, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28926804/name-that-tune-mitigation-of-driver-fatigue-via-a-song-naming-game
#9
Michael C Trumbo, Aaron P Jones, Charles S H Robinson, Kerstan Cole, James D Morrow
Fatigued driving contributes to a substantial number of motor vehicle accidents each year. Music listening is often employed as a countermeasure during driving in order to mitigate the effects of fatigue. Though music listening has been established as a distractor in the sense that it increases cognitive load during driving, it is possible that increased cognitive load is desirable under particular circumstances. For instance, during situations that typically result in cognitive underload, such as driving in a low-traffic monotonous stretch of highway, it may be beneficial for cognitive load to increase, thereby necessitating allocation of greater cognitive resources to the task of driving and attenuating fatigue...
September 16, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28922715/pm2-5-components-and-outpatient-visits-for-asthma-a-time-stratified-case-crossover-study-in-a-suburban-area
#10
Chau-Ren Jung, Li-Hao Young, Hui-Tsung Hsu, Ming-Yeng Lin, Yu-Cheng Chen, Bing-Fang Hwang, Perng-Jy Tsai
The effects of fine particles (PM2.5) on asthma have been widely confirmed by epidemiological research studies. However, a limited number of studies have investigated the relationship between exposure to different PM2.5 components and asthma. We characterized the PM2.5 components in a suburban site of central Taiwan and conducted a time-stratified case-crossover study to elaborate the effects of daily concentration of each PM2.5 component on asthma outpatient visits. We retrieved asthma outpatient claims for individuals less than 20 years old with a residential address in the Shalu district, Taiwan, from the National Health Insurance Research Database during 2000-2010...
September 12, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28921731/inter-observer-agreement-in-pediatric-cervical-spine-injury-assessment-between-prehospital-and-emergency-department-providers
#11
Lorin R Browne, Hamilton Schwartz, Fahd A Ahmad, Michael Wallendorf, Nathan Kuppermann, E Brooke Lerner, Julie C Leonard
BACKGROUND: Investigators have derived cervical spine injury (CSI) decision support tools from physician observations. There is a need to demonstrate that prehospital emergency medical services (EMS) providers can use these tools to appropriately determine the need for spinal motion restrictions and make field disposition decisions. OBJECTIVE: To determine the inter-observer agreement between EMS and emergency department (ED) providers for CSI risk assessment variables and overall gestalt for CSI in children after blunt trauma...
September 18, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28921600/injury-patterns-sustained-in-fatal-motor-vehicle-collisions-with-driver-s-third-generation-airbag-deployment
#12
Mariya Kuk, Michael J Shkrum
The Office of the Chief Coroner for Ontario database for 2011-2012 was used to compare fatal injury patterns in drivers whose third-generation airbags deployed compared to first- and second-generation airbag deployments and airbag nondeployments with and without seatbelt use. There were 110 frontal and offset frontal crashes analyzed. The small sample size meant that the odds of craniocerebral, cervical spinal, thoracic, and abdominal injuries were not statistically different for airbag generation, deployment status, and seatbelt use; however, the risk of fatal thoracic injuries in third- and second-generation cases was increased...
September 15, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28918840/neuroprotective-effects-of-eexenatide-in-a-rotenone-induced-rat-model-of-parkinson-s-disease
#13
Dürdane Aksoy, Volkan Solmaz, Türker Çavuşoğlu, Ayfer Meral, Utku Ateş, Oytun Erbaş
BACKROUND: Several studies suggest an association between Parkinson's disease (PD) and type 2 diabetes mellitus; these 2 diseases are both known to affect the common molecular pathways. As a synthetic agonist for the glucagon-like peptide 1 receptor, exenatide has been evaluated as a neuroprotective agent in multiple animal models. Rotenone models of PD have great potential for the investigation of PD pathology and motor and nonmotor symptoms, as well as the role of gene-environment interactions in PD causation and pathogenesis...
September 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28917584/pneumatoceles-in-pediatric-blunt-trauma-common-and-benign
#14
Lindsey B Armstrong, David P Mooney
INTRODUCTION: Traumatic pneumatoceles are reported to be rare in children and to have an uncertain clinical significance. We report a single institution series of traumatic pneumatoceles to better define their frequency and clinical significance. METHODS: After obtaining approval from the IRB, data were extracted from the trauma registry of a level 1 pediatric trauma center on children diagnosed with a pulmonary contusion (International Classification of Diseases-9th edition diagnosis codes: 861...
August 7, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28917504/update-on-the-risk-of-motor-vehicle-collision-or-driving-impairment-with-dementia-a-collaborative-international-systematic-review-and-meta-analysis
#15
REVIEW
Justin N Chee, Mark J Rapoport, Frank Molnar, Nathan Herrmann, Desmond O'Neill, Richard Marottoli, Sara Mitchell, Mark Tant, Jamie Dow, Debbie Ayotte, Krista L Lanctôt, Regina McFadden, John-Paul Taylor, Paul C Donaghy, Kirsty Olsen, Sherrilene Classen, Yoassry Elzohairy, David B Carr
Guidelines that physicians use to assess fitness to drive for dementia are limited in their currency, applicability, and rigor of development. Therefore, we performed a systematic review to determine the risk of motor vehicle collisions (MVCs) or driving impairment caused by dementia, in order to update international guidelines on driving with dementia. Seven literature databases (MEDLINE, CINAHL, Embase, etc.) were searched for all research studies published after 2004 containing participants with mild, moderate, or severe dementia...
May 15, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28916875/traumatic-injuries-to-the-pregnant-patient-a-critical-literature-review
#16
REVIEW
P Petrone, P Jiménez-Morillas, A Axelrad, C P Marini
INTRODUCTION: Trauma during pregnancy is the leading non-obstetrical cause of maternal death and a significant public health burden. This study reviews the most common causes of trauma during pregnancy, morbidity, and mortality, and the impact upon perinatal outcomes associated with trauma, providing a management approach to pregnant trauma patients. MATERIALS AND METHODS: A systematic review of the current literature from January 2006 to July 2016 was performed...
September 15, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28916171/neurobehavioral-assessment-of-mice-following-repeated-oral-exposures-to-domoic-acid-during-prenatal-development
#17
Motohiro Shiotani, Toby B Cole, Sungwoo Hong, Julie Ju Young Park, William C Griffith, Thomas M Burbacher, Tomomi Workman, Lucio G Costa, Elaine M Faustman
Domoic acid (DA) is an algal toxin which has been associated with significant neurotoxicity in humans, non-human primates, rodents, and marine mammals. Developmental exposure to DA is believed to result in neurotoxicity that may persist into adulthood. DA is produced by harmful algal blooms of Pseudo-nitzschia, raising concerns about the consumption of contaminated seafood. We evaluated oral exposures to DA during pregnancy in mice. Doses of 0 (vehicle), 1 or 3mg/kg/d of DA were administered by gavage to C57BL/6J mice on gestational days 10 to 17...
September 12, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/28915503/availability-and-consistency-of-health-and-non-health-data-for-road-traffic-fatality-analysis-of-data-from-195-countries-1985-2013
#18
Helai Huang, Qingyi Yin, David C Schwebel, Peishan Ning, Guoqing Hu
High-quality data are critical for validly monitoring progress toward global initiatives related to road traffic crash prevention. We assessed the availability and consistency of road traffic mortality data from health and non-health departments in national governments, plus changes in data consistency over time from 1985 to 2013. Using freely accessible data, we systematically assessed availability and consistency of health and non-health data from 1985 to 2013 in 195 countries. Data availability was reflected by the presence of data on motor vehicle mortality rates in that country at any points between 1985 and 2013...
September 12, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28915162/the-effect-of-perinatal-gadolinium-based-contrast-agents-on-adult-mice-behavior
#19
Miski Aghnia Khairinisa, Yusuke Takatsuru, Izuki Amano, Khongorzul Erdene, Takahito Nakajima, Satomi Kameo, Hiroshi Koyama, Yoshito Tsushima, Noriyuki Koibuchi
OBJECTIVES: The aim of this study was to examine the effects of perinatal exposure to gadolinium (Gd)-based contrast agents (GBCAs) on the behavior of adulthood offspring. MATERIALS AND METHODS: Pregnant Balb/C mice (n = 5 per group) were intravenously injected with gadoterate meglumine (Magnescope, macrocyclic GBCA), gadodiamide (Omniscan, linear GBCA), or vehicle from pregnancy day 15 to 19, corresponding to embryonic day 15 to 19 of the fetus, at 2 mmol/kg body weight per day...
September 14, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28915155/social-support-and-pain-outcomes-after-trauma-exposure-among-older-adults-a-multicenter-longitudinal-study
#20
Natalie L Richmond, Michelle L Meyer, Allison G Hollowell, Erin E Isenberg, Robert M Domeier, Robert A Swor, Phyllis L Hendry, David A Peak, Niels K Rathlev, Jeffrey S Jones, David C Lee, Christopher W Jones, Timothy F Platts-Mills
OBJECTIVES: Certain forms of social support have been shown to improve pain coping behaviors and pain outcomes in older adults with chronic pain, but little is known about the effect of social support on pain outcomes in older adults following trauma exposure. METHODS: We analyzed data from a prospective longitudinal study of adults aged 65 years and older presenting to an emergency department (ED) after a motor vehicle collision (MVC) to characterize the relationship between perceived social support and MVC-related pain after trauma overall and by subgroups based on gender, depressive symptoms, and marital status...
September 14, 2017: Clinical Journal of Pain
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