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https://www.readbyqxmd.com/read/28101880/family-emergency-plan-and-preparedness-among-medical-practitioners-in-zaria-nigeria
#1
Jerry Godfrey Makama, Istifanus Anekoson Joshua, Elizabeth Jerry Makama
BACKGROUND: There has been an increase in the incidence of disasters in many parts of the world. Similarly, Nigeria has witnessed a recent increase of man-made disaster events such as plane crash, fire incidents, flood, and building collapse, including bomb blast orchestrated by terrorists that often create emergency situations. Therefore, the aim of the study was to evaluate family emergency plan and preparedness among medical practitioners in Zaria. METHODS: This was a cross-sectional descriptive study (May-July, 2013) of medical practitioners in Zaria, Nigeria...
November 2016: Journal of Emergency Management: JEM
https://www.readbyqxmd.com/read/28100086/tracking-down-a-solution-exploring-the-acceptability-and-value-of-wearable-gps-devices-for-older-persons-individuals-with-a-disability-and-their-support-persons
#2
Brittany Williamson, Tammy Aplin, Desleigh de Jonge, Matthew Goyne
PURPOSE: To explore the acceptability and value of three wearable GPS devices for older persons and individuals with a disability and safety concerns when accessing the community. METHODS: This pilot study explored six wearers' and their support persons' experience of using three different wearable GPS devices (a pendant, watch, and mini GPS phone), each for a two-week period. RESULTS: Participants identified safety as the main value of using a wearable GPS device...
January 18, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/28098921/-does-less-seclusion-create-a-safer-environment-an-attempt-to-map-the-concept-of-feeling-safe
#3
C J Severs, A J K Hondius, A H Schene
The degree of restraint imposed by a psychiatrist seems to be influenced by the safety of the team. So far, there have been few attempts to map the concept of 'feeling safe'.<br/> AIM: To analyse, define and quantify the concept of 'feeling safe'.<br/> METHOD: Concept mapping involves combining, in a structured way, qualitative (item collection) and quantitative methods (multi-dimensional scaling and hierarchical clusteranalysis) with the knowledge of professionals from psychiatric practice (N=24), first on an individual basis and then as a group (N=8)...
2017: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/28088906/epratuzumab-and-blinatumomab-as-therapeutic-antibodies-for-treatment-of-pediatric-acute-lymphoblastic-leukemia-current-status-and-future-perspectives
#4
Raffaella Franca, Diego Favretto, Marilena Granzotto, Giuliana Decorti, Marco Rabusin, Gabriele Stocco
BACKGROUND: More than 85% of children affected by acute lymphoblastic leukemia (ALL) are successfully treated; however relapse remains a remarkable clinical concern, with 50-60% of relapsing patients facing a fatal outcome. Management of relapsed patients includes standardized intensive risk-adapted regimens based on conventional drugs, and hematopoietic stem cells transplantation for patients with unfavourable features. Biological drugs, in particular the monoclonal antibody epratuzumab and the bi-functional recombinant single chain peptide blinatumomab, have been recently recognized as novel potential agents to be integrated in salvage ALL therapy to further improve rescue outcome...
January 12, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28088636/comparison-of-mucoadhesive-and-cohesive-features-of-poly-acrylic-acid-conjugates-respective-their-molecular-mass
#5
Flavia Laffleur, Kathrin Knapp, Wongsakorn Suchaoin, Alexandra Partenhauser, Kesinee Netsomboon, Andreas Bernkop-Schnürch
OBJECTIVES: This study aimed to assess the impact of molecular mass as well as the differences between poly(acrylic acid)-thiol-conjugates (PAA100,250,450 KDa) on their mucoadhesive and cohesive qualities. METHODS: Covalent attachment of cysteine (CYS), cysteamine (CYSM) and L-gluthathione (GSH) to poly(acrylic acid) was achieved by formation of amide bonds between primary amino group of the amino acid (in the case of cysteine and glutathione), respectively the amino group of the aminothiol cysteamine and carboxylic acid group of the polymer...
January 11, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28087451/in-depth-comparative-analysis-of-the-chicken-eggshell-membrane-proteome
#6
Tamer A E Ahmed, Henri-Pierre Suso, Maxwell T Hincke
: The avian eggshell membrane (ESM) is stabilized by extensive cross-linkages, making the identification of its protein constituents technically challenging. Herein, we applied various extraction/solubilization conditions followed by proteomic analysis to characterize the protein constituents of ESM derived from the unfertilized chicken eggs. The egg white and eggshell proteomes (including previous published work) were determined and compared to ESM to identify proteins that are relatively or highly specific to ESM...
January 10, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28076702/lasmiditan-for-the-treatment-of-migraine
#7
Matilde Capi, Fernando de Andrés, Luana Lionetto, Giovanna Gentile, Fabiola Cipolla, Marina Borro, Paolo Martelletti, Martina Curto
Migraine is one of the most common diseases in the world, with high economical and subjective burden. Migraine acute therapy is nowadays based on specific and non-specific drugs but up to 40% of episodic migraineurs still have unmet treatment needs and over 35% do not benefit from triptans administration. Serotonin-1F receptors have been identified in trigeminal system and became an ideal target for anti-migraine drug development as potential trigeminal neural inhibitors. Lasmiditan, a novel serotonin1F receptor agonist, showed specific affinity in vitro for the receptor with any vasoconstrictive action and inhibited markers associated with electrical stimulation of trigeminal ganglion in migraine animal models...
January 11, 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28076582/interventions-that-facilitate-sustainable-jobs-and-have-a-positive-impact-on-workers-health-an-overview-of-systematic-reviews
#8
Michelle M Haby, Evelina Chapman, Rachel Clark, Luiz A C Galvão
Objective: To identify interventions that facilitate sustainable jobs and have a positive impact on the health of workers in health sector workplaces. Methods: This overview utilized systematic review methods to synthesize evidence from multiple systematic reviews and economic evaluations. A comprehensive search was conducted based on a predefined protocol, including specific inclusion criteria. To be classified as "sustainable," interventions needed to aim (explicitly or implicitly) to 1) have a positive impact on at least two key dimensions of the integrated framework for sustainable development and 2) include measures of health impact...
November 2016: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28075043/all-organic-rechargeable-battery-with-reversibility-supported-by-water-in-salt-electrolyte
#9
Xiaoli Dong, Hongchuan Yu, Yuanyuan Ma, Junwei Lucas Bao, Donald G Truhlar, Yonggang Wang, Yongyao Xia
Rechargeable batteries with organic electrodes are preferred to those with transition-metal-containing electrodes for their environmental friendliness and resource availability, but all such batteries reported to date are based on organic electrolytes, which raise concerns of safety and performance. Here we report an aqueous-electrolyte all-organic rechargeable battery with a maximum operating voltage of 2.1 V, in which polytriphenylamine (PTPAn) and 1,4,5,8-naphthalenetetracarboxylic dianhydride (NTCDA)-derived polyimide (PNTCDA) serve as cathode and anode material, respectively...
January 11, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28074899/mof-derived-multifractal-porous-carbon-with-ultrahigh-lithium-ion-storage-performance
#10
Ang Li, Yan Tong, Bin Cao, Huaihe Song, Zhihong Li, Xiaohong Chen, Jisheng Zhou, Gen Chen, Hongmei Luo
Porous carbon is one of the most promising alternatives to traditional graphite materials in lithium-ion batteries. This is not only attributed to its advantages of good safety, stability and electrical conductivity, which are held by all the carbon-based electrodes, but also especially ascribed to its relatively high capacity and excellent cycle stability. Here we report the design and synthesis of a highly porous pure carbon material with multifractal structures. This material is prepared by the vacuum carbonization of a zinc-based metal-organic framework, which demonstrates an ultrahigh lithium storage capacity of 2458 mAh g(-1) and a favorable high-rate performance...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28072708/life-threatening-motor-vehicle-crashes-in-bright-sunlight
#11
Donald A Redelmeier, Sheharyar Raza
: Bright sunlight may create visual illusions that lead to driver error, including fallible distance judgment from aerial perspective. We tested whether the risk of a life-threatening motor vehicle crash was increased when driving in bright sunlight.This longitudinal, case-only, paired-comparison analysis evaluated patients hospitalized because of a motor vehicle crash between January 1, 1995 and December 31, 2014. The relative risk of a crash associated with bright sunlight was estimated by evaluating the prevailing weather at the time and place of the crash compared with the weather at the same hour and location on control days a week earlier and a week later...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28070828/hypofractionated-stereotactic-radiosurgery-for-pituitary-metastases
#12
Haemin Chon, KyoungJun Yoon, Do Hoon Kwon, Chang Jin Kim, Min-Seon Kim, Young Hyun Cho
Pituitary metastases (PMs) are uncommon, representing only 1% of pituitary lesions. The diagnosis of PMs can be challenging and an optimal management remains to be determined. Here, we present a pilot clinical study on the efficacy and safety of hypofractionated stereotactic radiosurgery (SRS) with an optimized dosimetric plan in treating PMs. Between June 2013 and December 2014, seven consecutive patients (4 men and 3 women; median age 62 years) had been diagnosed with PMs based on their characteristic clinical and radiological features and subsequently treated using hypofractionated SRS...
January 9, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28068498/adapting-dialectical-behavior-therapy-for-the-treatment-of-dissociative-identity-disorder
#13
Brad Foote, Kim Van Orden
Dialectical Behavior Therapy (DBT), created by Marsha Linehan, has been shown to be an effective therapy for the treatment of borderline personality disorder (BPD) and for suicidal and self-harming behavior. Dissociative identity disorder (DID) is a complex post-traumatic disorder which is highly comorbid with BPD, shares a number of clinical features with BPD, and which like BPD features a high degree of suicidality. The DID treatment literature emphasizes the importance of a staged approach, beginning with the creation of a safe therapeutic frame prior to addressing traumatic material; DBT is also a staged treatment, in which behavioral and safety issues are addressed in Stage 1, and trauma work reserved for Stage 2...
December 31, 2016: American Journal of Psychotherapy
https://www.readbyqxmd.com/read/28067539/identification-of-species-adulteration-in-traded-medicinal-plant-raw-drugs-using-dna-barcoding
#14
Stalin Nithaniyal, Sophie Lorraine Vassou, Sundar Poovitha, Balaji Raju, Madasamy Parani
Plants are the major source of therapeutic ingredients in complementary and alternative medicine (CAM). However, species adulteration in traded medicinal plant raw drugs threatens the reliability and safety of CAM. Since morphological features of medicinal plants are often not intact in the raw drugs, DNA barcoding was employed for species identification. Adulteration in 112 traded raw drugs was tested after creating a reference DNA barcode library consisting of 1452 rbcL and matK barcodes from 521 medicinal plant species...
October 14, 2016: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/28067165/gene-therapy-in-fanconi-anemia-a-matter-of-time-safety-and-gene-transfer-tool-efficiency
#15
Verhoeyen Els, Francisco José Román Rodríguez, François-Loïc Cosset, Camille Lévy, Paula Rio
Fanconi anemia (FA) is a rare genetic syndrome characterized by progressive marrow failure. Gene therapy by infusion of FA-corrected autologous hematopoietic stem cells (HSCs) may offer a potential cure since it is a monogenetic disease with mutations in the FANC genes, coding for DNA repair enzymes (See review[1]). However, the collection of hCD34 +-cells in FA patients implies particular challenges because of the reduced numbers of progenitor cells present in their bone marrow (BM)[2] or mobilized peripheral blood[3-5]...
January 9, 2017: Current Gene Therapy
https://www.readbyqxmd.com/read/28066851/analysis-of-smartphone-interruptions-on-academic-general-internal-medicine-wards-frequent-interruptions-may-cause-a-crisis-mode-work-climate
#16
Alon Vaisman, Robert C Wu
INTRODUCTION: Hospital-based medical services are increasingly utilizing team-based pagers and smartphones to streamline communications. However, an unintended consequence may be higher volumes of interruptions potentially leading to medical error. There is likely a level at which interruptions are excessive and cause a 'crisis mode' climate. METHODS: We retrospectively collected phone, text messaging, and email interruptions directed to hospital-assigned smartphones on eight General Internal Medicine (GIM) teams at two tertiary care centres in Toronto, Ontario from April 2013 to September 2014...
January 4, 2017: Applied Clinical Informatics
https://www.readbyqxmd.com/read/28065812/minimally-invasive-approach-in-type-ii-endometrial-cancer-it-is-wise-and-safe
#17
Giorgia Monterossi, Fabio Ghezzi, Enrico Vizza, Gian Franco Zannoni, Stefano Uccella, Giacomo Corrado, Stefano Restaino, Lorena Quagliozzi, Jvan Casarin, Giorgia Dinoi, Giovanni Scambia, Francesco Fanfani
STUDY OBJECTIVE: The aims of this study were to compare peri-operative and survival outcomes of Type II endometrial cancers patients staged by minimally invasive approaches versus laparotomy. DESIGN: A retrospective cohort study. DESIGN: Classification: Canadian Task Force classification II-2 SETTING: Catholic University of the Sacred Heart of Rome, University of Insubria, Varese and "Regina Elena" National Cancer Institute of Rome. PATIENTS: We enrolled 283 Type II endometrial cancer patients with clinical FIGO stage I-II and pathological stage III with apparent early-stage disease at the pre-operative instrumental examination...
January 5, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28061924/asymptomatic-wolff-parkinson-white-pattern-ecg-in-usaf-aviators
#18
Eddie D Davenport, Karen A N Rupp, Edwin Palileo, Jared Haynes
INTRODUCTION: Wolff-Parkinson-White (WPW) pattern is occasionally found in asymptomatic aviators during routine ECGs. Aeromedical concerns regarding WPW pattern include risk of dysrhythmia or sudden cardiac death (SCD), thus affecting the safety of flight. The purpose of this study was to determine the prevalence and outcomes of aviators with asymptomatic WPW pattern and assess for risk factors that contribute to progression to dysrhythmia or symptoms. METHODS: The U...
January 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28061895/initial-experience-with-laparoscopic-radical-antegrade-modular-pancreatosplenectomy-for-left-sided-pancreatic-cancer-in-a-single-institution-technical-aspects-and-oncological-outcomes
#19
Eun Young Kim, Tae Ho Hong
BACKGROUND: Laparoscopic surgery has been performed less frequently in the era of pancreatic cancer due to technical difficulties and concerns about oncological safety. Radical antegrade modular pancreatosplenectomy (RAMPS) is expected to be helpful to obtain a negative margin during radical lymph node dissection. We hypothesized that it would also be favorable as a laparoscopic application due to unique features. METHODS: Fifteen laparoscopic RAMPS for well-selected patients with left-sided pancreatic cancer were performed from July 2011 to April 2016...
January 7, 2017: BMC Surgery
https://www.readbyqxmd.com/read/28060539/bococizumab-for-the-treatment-of-hypercholesterolaemia
#20
Nicola Ferri, Alberto Corsini, Cesare R Sirtori, Massimiliano Ruscica
Low-density lipoprotein cholesterol (LDL-C) remains a well-established risk factor for cardiovascular disease (CVD). LDL-C levels are considered primary targets of therapy. A new series of systemic biomolecules, the monoclonal antibodies (mAbs) of proprotein convertase subtilisin/kexin type 9 (PCSK9), have a higher activity in reducing LDL-C. Areas covered: The authors critically review the current evidence on the efficacy and safety of bococizumab, a humanized mAb against PCSK9, which was surprisingly discontinued in November 2016...
February 2017: Expert Opinion on Biological Therapy
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