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https://www.readbyqxmd.com/read/28938106/assessment-of-a-specifically-developed-bullet-casing-gun-for-the-stunning-of-water-buffaloes
#1
Carmen Meichtry, Urs Glauser, Matthieu Glardon, Steffen G Ross, Isabel Lechner, Beat P Kneubuehl, Dominic Gascho, Claudia Spadavecchia, Alois von Rotz, Ana Stojiljkovic, Michael H Stoffel
Water buffaloes and cattle differ considerably with respect to the anatomy of the head. As a result, captive bolt stunners often fail to reliably produce adequate loss of consciousness in water buffaloes and, thus, do not fulfill animal welfare requirements. The goal of the present study was to assess and validate a new stunning device for water buffaloes meeting animal welfare and occupational safety requirements. The newly designed bullet casing gun uses .357Mag/10.2g hollow point bullets and has additional safety features...
September 14, 2017: Meat Science
https://www.readbyqxmd.com/read/28936829/-protocol-of-intensive-hospital-monitoring-with-long-follow-up-and-large-sample-diemailing-kudiezi-injection-as-example
#2
Xing Liao, Yan-Ming Xie, Gui-Qian Wang
This is a protocol of intensive hospital monitoring with long follow up and large sample of Diemailing Kudiezi injection, which aims to identify adverse drug reactions(ADRs) of Diemailing Kudiezi injection, including known incidence of adverse reactions, the incidence of new adverse reactions, the incidence of various ADR symptoms and the incidence of ADR among the sub populations; clarify the clinical features of ADRs of Diemailing Kudiezi injection; explore risk factors for ADRs; and analyze their usage in real world...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28935492/clinical-predictors-of-response-and-discontinuation-of-belimumab-in-patients-with-systemic-lupus-erythematosus-in-real-life-setting-results-of-a-large-multicentric-nationwide-study
#3
Luca Iaccarino, Laura Andreoli, Elena Bartoloni Bocci, Alessandra Bortoluzzi, Fulvia Ceccarelli, Fabrizio Conti, Rossella De Angelis, Ginevra De Marchi, Salvatore De Vita, Andrea Di Matteo, Giacomo Emmi, Lorenzo Emmi, Mariele Gatto, Roberto Gerli, Maria Gerosa, Marcello Govoni, Maddalena Larosa, Pier Luigi Meroni, Marta Mosca, Giulia Pazzola, Rossella Reggia, Francesca Saccon, Carlo Salvarani, Chiara Tani, Margherita Zen, Anna Chiara Frigo, Angela Tincani, Andrea Doria
OBJECTIVE: To investigate efficacy, safety and survival of belimumab and to identify predictors of drug response and drug discontinuation in patients with active SLE in clinical practice. PATIENTS AND METHODS: Data of SLE patients, treated with belimumab, from 11 Italian prospective cohorts were analyzed. SLEDAI-2K, anti-dsDNA, C3, C4, prednisone daily dose, DAS-28, 24-h proteinuria, CLASIa (Cutaneous LE Disease Area and Severity Index Activity) were recorded at baseline and every 6 months...
September 18, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28934249/variability-in-objective-and-subjective-measures-affects-baseline-values-in-studies-of-patients-with-copd
#4
Wayne H Anderson, Jae Wook Ha, David J Couper, Wanda K O'Neal, R Graham Barr, Eugene R Bleecker, Elizabeth E Carretta, Christopher B Cooper, Claire M Doerschuk, M Bradley Drummond, MeiLan K Han, Nadia N Hansel, Victor Kim, Eric C Kleerup, Fernando J Martinez, Stephen I Rennard, Donald Tashkin, Prescott G Woodruff, Robert Paine, Jeffrey L Curtis, Richard E Kanner
RATIONALE: Understanding the reliability and repeatability of clinical measurements used in the diagnosis, treatment and monitoring of disease progression is of critical importance across all disciplines of clinical practice and in clinical trials to assess therapeutic efficacy and safety. OBJECTIVES: Our goal is to understand normal variability for assessing true changes in health status and to more accurately utilize this data to differentiate disease characteristics and outcomes...
2017: PloS One
https://www.readbyqxmd.com/read/28933682/q-vaxcelerate-a-distributed-development-approach-for-a-new-coxiella-burnetii-vaccine
#5
Patrick M Reeves, Susan Raju Paul, Ann E Sluder, Timothy A Brauns, Mark C Poznansky
Development of vaccines that are both safe and effective remains a costly and time-consuming challenge. To accelerate the pace of development and improve the efficacy and safety of candidate vaccines for both existing and emerging infectious agents, we have employed a distributed development approach. This features the managed integration of individual expert groups having the requisite vaccine platforms, pre-clinical models, assays, skills and knowledge pertinent to a specific pathogen into a single, end-to-end development team capable of producing a new vaccine tailored to that particular agent...
September 21, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28933516/anti-il5-therapies-for-asthma
#6
REVIEW
Hugo A Farne, Amanda Wilson, Colin Powell, Lynne Bax, Stephen J Milan
BACKGROUND: This review is the first update of a previously published review in The Cochrane Library (Issue 7, 2015). Interleukin-5 (IL-5) is the main cytokine involved in the activation of eosinophils, which cause airway inflammation and are a classic feature of asthma. Monoclonal antibodies targeting IL-5 or its receptor (IL-5R) have been developed, with recent studies suggesting that they reduce asthma exacerbations, improve health-related quality of life (HRQoL) and lung function...
September 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28932272/the-place-of-eluxadoline-in-the-management-of-irritable-bowel-syndrome-with-diarrhea
#7
REVIEW
Sherry Levio, Brooks D Cash
Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder characterized by abdominal pain associated with defecation with altered stool frequency or stool form. The global prevalence of IBS ranges from 10% to 15% and total healthcare cost attributable to IBS is significant. Among individuals with IBS, the condition has dramatic effects on health-related quality of life, work and school productivity, and activities of daily living. It may be diagnosed with confidence, based on symptom-based diagnostic criteria, exclusion of alarm features and directed diagnostic testing...
September 2017: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/28931647/randomized-open-label-trial-of-dextromethorphan-in-rett-syndrome
#8
Constance L Smith-Hicks, Siddharth Gupta, Joshua B Ewen, Manisha Hong, Lisa Kratz, Richard Kelley, Elaine Tierney, Rebecca Vaurio, Genila Bibat, Abanti Sanyal, Gayane Yenokyan, Nga Brereton, Michael V Johnston, Sakkubai Naidu
OBJECTIVE: To determine safety and perform a preliminary assessment of dose-dependent efficacy of dextromethorphan in normalizing electrographic spikes, clinical seizures, and behavioral and cognitive functions in girls with Rett syndrome. METHODS: We used a prospective randomized, open-label trial in fast metabolizers of dextromethorphan to examine the effect of dextromethorphan on core clinical features of Rett syndrome. Interictal spike activity and clinical seizures were determined using EEG and parent reporting...
September 20, 2017: Neurology
https://www.readbyqxmd.com/read/28931397/pseudomonas-stutzeri-as-an-alternative-host-for-membrane-proteins
#9
Manuel Sommer, Hao Xie, Hartmut Michel
BACKGROUND: Studies on membrane proteins are often hampered by insufficient yields of the protein of interest. Several prokaryotic hosts have been tested for their applicability as production platform but still Escherichia coli by far is the one most commonly used. Nevertheless, it has been demonstrated that in some cases hosts other than E. coli are more appropriate for certain target proteins. RESULTS: Here we have developed an expression system for the heterologous production of membrane proteins using a single plasmid-based approach...
September 20, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28930858/a-retrospective-study-comparing-percutaneous-and-open-pedicle-screw-fixation-for-thoracolumbar-fractures-with-spinal-injuries
#10
Bowen Wang, Yong Fan, Jingjing Dong, Hu Wang, Faqi Wang, Zhichen Liu, Haoyuan Liu, Yafei Feng, Fengrong Chen, Zheyuan Huang, Ruisong Chen, Wei Lei, Zixiang Wu
BACKGROUND: The purpose of this study was to evaluate the effectiveness between percutaneous and open pedicle screw fixation for treating thoracolumbar fractures with spinal injuries. METHODS: A total of 105 patients with thoracolumbar fractures and spinal injuries were divided into a percutaneous pedicle screw fixation (PPSF) group with 56 patients, who underwent percutaneous pedicle screw fixation, and an open pedicle screw fixation (OPSF) group with 49 patients, who underwent open pedicle screw fixation in accordance with the treatment project...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28929421/immunotherapy-of-food-allergy-a-comprehensive-review
#11
REVIEW
Christine Y Y Wai, Nicki Y H Leung, Patrick S C Leung, Ka Hou Chu
Food allergy imposes a severe global health burden, and thus, there is a dire need for safe and effective treatments. Allergen-specific immunotherapy (AIT) is currently the only approach to restore immune tolerance through administrating increasing doses of allergen extracts. Unfortunately, the development of AIT for food allergies has been impeded by the frequent anaphylactic side effects during the course of treatment. The emergence of component-resolved diagnosis has greatly improved our ability to identify causative allergens and revolutionized the design of AIT...
September 19, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28929207/-securpharm-e-%C3%A2-v-a%C3%A2-protective-shield-against-falsified-medicines
#12
REVIEW
Martin Bergen, Reinhard Hoferichter
It is the declared objective of the Falsified Medicines Directive 2011/62/EU to further improve the protection of patients from falsified pharmaceuticals. Therefore, it stipulates measures based on which falsified medicines in the supply chain can be more easily identified. This is the European legislature's reaction to an increase in falsified medicines. The EU Falsified Medicines Directive aims to create a uniform, standardized solution for protection from falsified drugs. From 9 February 2019 onward (according to the EU Regulation No...
September 19, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28929177/-falsified-pharmaceutical-products-legislative-measures-in-the-european-union-and-in-germany
#13
REVIEW
Burkhard Sträter
Falsified pharmaceutical products are multi-faceted and driven by great criminal power. The health risks for patients who are frequently very seriously ill are high. The problem in Europe has been recognised. The European Union has created statutory requirements that considerably improve and tighten the system of manufacturing, distribution and documentation, and of pharmaceutical product authorisations. The traceability of each package via safety features is strengthened and made binding by detailed delegated legislation...
September 19, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28929015/the-landscape-of-fear-conceptual-framework-definition-and-review-of-current-applications-and-misuses
#14
Sonny S Bleicher
Landscapes of Fear (LOF), the spatially explicit distribution of perceived predation risk as seen by a population, is increasingly cited in ecological literature and has become a frequently used "buzz-word". With the increase in popularity, it became necessary to clarify the definition for the term, suggest boundaries and propose a common framework for its use. The LOF, as a progeny of the "ecology of fear" conceptual framework, defines fear as the strategic manifestation of the cost-benefit analysis of food and safety tradeoffs...
2017: PeerJ
https://www.readbyqxmd.com/read/28928044/electrocardiographic-biomarkers-to-confirm-drug-s-electrophysiological-effects-used-for-proarrhythmic-risk-prediction-under-cipa
#15
Jose Vicente, Meisam Hosseini, Lars Johannesen, David G Strauss
The ECG plays a critical role in the thorough QT study. This clinical study is part of the assessment of proarrhythmic potential of drugs under the current regulatory paradigm. While the current paradigm has been successful in preventing drugs with unexpected QT prolongation or torsade risk from reaching the market, the focus on QT prolongation has likely resulted in potentially beneficial compounds with minimal torsade risk being dropped from development. The Comprehensive in vitro Proarrhythmia Assay (CiPA) initiative is developing and validating a new mechanistic-based paradigm for cardiac safety evaluation of drugs...
August 9, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28926300/an-updated-scheme-for-categorizing-foods-implicated-in-foodborne-disease-outbreaks-a-tri-agency-collaboration
#16
LaTonia C Richardson, Michael C Bazaco, Cary Chen Parker, Daniel Dewey-Mattia, Neal Golden, Karen Jones, Karl Klontz, Curtis Travis, Joanna Zablotsky Kufel, Dana Cole
BACKGROUND: Foodborne disease data collected during outbreak investigations are used to estimate the percentage of foodborne illnesses attributable to specific food categories. Current food categories do not reflect whether or how the food has been processed and exclude many multiple-ingredient foods. MATERIALS AND METHODS: Representatives from three federal agencies worked collaboratively in the Interagency Food Safety Analytics Collaboration (IFSAC) to develop a hierarchical scheme for categorizing foods implicated in outbreaks, which accounts for the type of processing and provides more specific food categories for regulatory purposes...
September 19, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28923691/submucosal-tunneling-endoscopic-resection-vs-thoracoscopic-enucleation-for-large-submucosal-tumors-in-the-esophagus-and-the-esophagogastric-junction
#17
Tao Chen, Zong-Wu Lin, Yi-Qun Zhang, Wei-Feng Chen, Yun-Shi Zhong, Qun Wang, Li-Qing Yao, Ping-Hong Zhou, Mei-Dong Xu
BACKGROUND: Submucosal tunneling endoscopic resection (STER) is regarded as a promising method for resection of submucosal tumors (SMTs); however, little is known about a comprehensive comparison of STER and thoracoscopic enucleation (TE). The aim of this study is to compare the clinical outcomes of STER and TE for large symptomatic SMTs in the esophagus and the esophagogastric junction (EGJ), as well as to analyze the factors that affect the feasibility and safety of STER. STUDY DESIGN: We enrolled 166 patients with large symptomatic SMTs in the esophagus and the EGJ from September 2011 and March 2016 in this retrospective study...
September 15, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28922876/visual-deficit-from-laser-interstitial-thermal-therapy-for-temporal-lobe-epilepsy-anatomical-considerations
#18
Walter J Jermakowicz, Michael E Ivan, Iahn Cajigas, Ramses Ribot, Ignacio Jusue-Torres, Mehul B Desai, Armando Ruiz, Pierre-Francois D'Haese, Andres M Kanner, Jonathan R Jagid
BACKGROUND: Laser interstitial thermal therapy (LITT) is quickly emerging as an effective surgical therapy for temporal lobe epilepsy (TLE). One of the most frequent complications of the procedure is postoperative visual field cuts, but the physiopathology of these deficits is unknown. OBJECTIVE: To evaluate potential causes of visual deficits after LITT for TLE in an attempt to minimize this complication. METHODS: This retrospective chart review compares the case of a 24-year-old male who developed homonymous hemianopsia following LITT for TLE to 17 prior patients who underwent the procedure and suffered no visual deficit...
October 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28918419/-about-the-association-between-antipsychotic-medication-and-cardiovascular-morbidity-epidemiology-and-possible-background-mechanisms
#19
Gabor Gaszner, Gabor Barna, Peter Dome
The history of antipsychotics began with the discovery of chlorpromazine in the 1950s. Since then this group of medications has become one of the most important element of the armamentarium of psychopharmacology. While initially these pharmacons were used in the treatment of psychotic states (including psychotic mania) in the last approximately 10-15 years new indications - such as treatment of depressive, manic and mixed states and also mood-stabilization in bipolar disorder and also the treatment of major depressive disorder - for several second-generation antipsychotic (SGA) agents have been introduced...
June 2017: Neuropsychopharmacologia Hungarica
https://www.readbyqxmd.com/read/28918017/efficacy-and-safety-profile-of-tricyclo-dna-antisense-oligonucleotides-in-duchenne-muscular-dystrophy-mouse-model
#20
Karima Relizani, Graziella Griffith, Lucía Echevarría, Faouzi Zarrouki, Patricia Facchinetti, Cyrille Vaillend, Christian Leumann, Luis Garcia, Aurélie Goyenvalle
Antisense oligonucleotides (AONs) hold promise for therapeutic splice-switching correction in many genetic diseases. However, despite advances in AON chemistry and design, systemic use of AONs is limited due to poor tissue uptake and sufficient therapeutic efficacy is still difficult to achieve. A novel class of AONs made of tricyclo-DNA (tcDNA) is considered very promising for the treatment of Duchenne muscular dystrophy (DMD), a neuromuscular disease typically caused by frameshifting deletions or nonsense mutations in the gene-encoding dystrophin and characterized by progressive muscle weakness, cardiomyopathy, and respiratory failure in addition to cognitive impairment...
September 15, 2017: Molecular Therapy. Nucleic Acids
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