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https://www.readbyqxmd.com/read/28820587/flupyrimin-a-novel-insecticide-acting-at-the-nicotinic-acetylcholine-receptors
#1
Yasumichi Onozaki, Ryo Horikoshi, Ikuya Ohno, Shigeki Kitsuda, Kathleen A Durkin, Tomonori Suzuki, Chiaki Asahara, Natsuko Hiroki, Rena Komabashiri, Rikako Shimizu, Shogo Furutani, Makoto Ihara, Kazuhiko Matsuda, Masaaki Mitomi, Shinzo Kagabu, Katsuhito Uomoto, Motohiro Tomizawa
A novel chemotype insecticide flupyrimin (FLP) [N-[(E)-1-(6-chloro-3-pyridinylmethyl)pyridin-2(1H)-ylidene]-2,2,2-trifluoroacetamide], discovered by Meiji Seika Pharma, has unique biological properties including outstanding potency to imidacloprid (IMI)-resistant rice pests together with superior safety toward pollinators. Intriguingly, FLP acts as a nicotinic antagonist in American cockroach neurons and [3H]FLP binds to the multiple high-affinity binding components in house fly nicotinic acetylcholine (ACh) receptor (nAChR) preparation...
August 18, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28819053/novel-neurobiological-properties-of-elements-in-the-escape-circuitry-of-the-shrimp
#2
De Forest Mellon
Escape behaviors in peneid shrimp are mediated by large myelinated medial giant fibers which course from the brain to the last abdominal ganglion in the ventral nerve cord. In each abdominal segment the medial giant axons make synaptic connections with paired myelinated giant motor axons that excite the abdominal deep flexor muscles and drive the tailflips that constitute the escape behavior. I examined 1) anatomical features of the abdominal motor giant fibers and 2) electrical properties of both the medial giants and motor giants in the pink shrimp, Farfantepenaeus duoarum...
August 17, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28818469/vaccine-epidemiology-its-role-in-promoting-sound-immunization-programs-in-japan
#3
Yoshio Hirota, Kotaro Ozasa, Takashi Nakano
In Japan, the Vaccine Epidemiology Research Group created by the Ministry of Health, Labour and Welfare has played an important role in demonstrating the solid scientific basis for vaccine efficacy and safety since 2002. Members of the group, including epidemiologists, clinicians and microbiologists, have been conducting collaborative studies on vaccines for influenza, pertussis, rotavirus gastroenteritis, polio and pneumonia. So far, the group has achieved several works and contributed to the national vaccination program, including research on the immunogenicity of low doses of influenza vaccine among young children, the immunogenicity and effectiveness of the 2009 influenza pandemic vaccine among various risk groups, the interchangeability of live/inactivated polio vaccines, the health impact of influenza on pregnant women, and the monitoring of influenza vaccine effectiveness using case-control studies with a test-negative design...
August 24, 2017: Vaccine
https://www.readbyqxmd.com/read/28818165/effectiveness-and-safety-of-sofosbuvir-in-treatment-n%C3%A3-ivechildren-with-hepatitis-c-infection
#4
Muhammad Almas Hashmi, Huma Arshad Cheema
OBJECTIVE: To determine the effectiveness and safety of Sofosbuvir and Ribavirin combination in treatment-näivechildren with HCV infection. STUDY DESIGN: An experimental study. PLACE AND DURATION OF STUDY: Gastroentrology, Hepatology Department, The Children's Hospital and The Institute of Child Health, Lahore, from January to December 2016. METHODOLOGY: HCV PCR positive treatment-näivepatients, 5 to 18 years of age, were enrolled by consecutive nonprobability sampling...
July 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28815800/a-method-for-data-driven-exploration-to-pinpoint-key-features-in-medical-data-and-facilitate-expert-review
#5
Kristina Juhlin, Kristina Star, G Niklas Norén
PURPOSE: To develop a method for data-driven exploration in pharmacovigilance and illustrate its use by identifying the key features of individual case safety reports related to medication errors. METHODS: We propose vigiPoint, a method that contrasts the relative frequency of covariate values in a data subset of interest to those within one or more comparators, utilizing odds ratios with adaptive statistical shrinkage. Nested analyses identify higher order patterns, and permutation analysis is employed to protect against chance findings...
August 16, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28815550/fertility-preservation-in-women-with-borderline-ovarian-tumors-how-does-it-impact-disease-outcome-a-cohort-study
#6
Limor Helpman, Assaf Yaniv, Mario E Beiner, Sarit Aviel-Ronen, Tamar Perri, Gilad Ben-Baruch, Liat Hogen Ben-David, Ariella Jakobson-Setton, Jacob Korach
INTRODUCTION: Borderline ovarian tumors are typically indolent neoplasms. Since many are diagnosed in younger women, fertility conservation is an important consideration and has been advocated based on retrospective data. The objective of this study was to identify features impacting on recurrence and survival in a series of borderline ovarian tumors, and to assess the safety of a fertility-sparing approach. MATERIAL AND METHODS: A historical cohort study of consecutive borderline ovarian tumors cases treated at a single institution over 30 years (1981-2011)...
August 16, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28815480/evaluation-of-electronic-healthcare-databases-for-post-marketing-drug-safety-surveillance-and-pharmacoepidemiology-in-china
#7
Yu Yang, Xiaofeng Zhou, Shuangqing Gao, Hongbo Lin, Yanming Xie, Yuji Feng, Kui Huang, Siyan Zhan
INTRODUCTION: Electronic healthcare databases (EHDs) are used increasingly for post-marketing drug safety surveillance and pharmacoepidemiology in Europe and North America. However, few studies have examined the potential of these data sources in China. METHODS: Three major types of EHDs in China (i.e., a regional community-based database, a national claims database, and an electronic medical records [EMR] database) were selected for evaluation. Forty core variables were derived based on the US Mini-Sentinel (MS) Common Data Model (CDM) as well as the data features in China that would be desirable to support drug safety surveillance...
August 16, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28813889/design-of-a-clinically-relevant-upper-limb-exoskeleton-robot-for-stroke-patients-with-spasticity
#8
Dong Jin Lee, Sung Jin Bae, Sung Ho Jang, Pyung Hun Chang
The purpose of this research is to propose a design of a clinically relevant upper-limb (hand, wrist, and elbow) exoskeleton that meets the clinical requirements. At first, the proposed robot was designed to have sufficient torque for passive exercise therapy and spasticity measurement of post-stroke patients with spasticity (grade 3 or lower in Modified Ashworth Scale). Because the therapy of patients with high level spasticity could be laborious for therapists by increased muscle tone, and the patients tend not to get enough rehabilitation treatment...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28811987/early-complications-and-outcomes-in-adult-spinal-deformity-surgery-an-nsqip-study-based-on-5803-patients
#9
Nathan J Lee, Parth Kothari, Jun S Kim, John I Shin, Kevin Phan, John Di Capua, Sulaiman Somani, Dante M Leven, Javier Z Guzman, Samuel K Cho
STUDY DESIGN: Retrospective analysis. OBJECTIVE: The purpose of this study is to determine the incidence, impact, and risk factors for short-term postoperative complications following elective adult spinal deformity (ASD) surgery. METHODS: Current Procedural Terminology codes were used to query the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) for adults who underwent spinal deformity surgery from 2010 to 2014...
August 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28811571/identification-of-a-gene-encoding-slow-skeletal-muscle-troponin-t-as-a-novel-marker-for-immortalization-of-retinal-pigment-epithelial-cells
#10
Takuya Kuroda, Satoshi Yasuda, Hiroyuki Nakashima, Nozomi Takada, Satoko Matsuyama, Shinji Kusakawa, Akihiro Umezawa, Akifumi Matsuyama, Shin Kawamata, Yoji Sato
Human pluripotent stem cells (hPSCs) are leading candidate raw materials for cell-based therapeutic products (CTPs). In the development of hPSC-derived CTPs, it is imperative to ensure that they do not form tumors after transplantation for safety reasons. Because cellular immortalization is a landmark of malignant transformation and a common feature of cancer cells, we aimed to develop an in vitro assay for detecting immortalized cells in CTPs. We employed retinal pigment epithelial (RPE) cells as a model of hPSC-derived products and identified a gene encoding slow skeletal muscle troponin T (TNNT1) as a novel marker of immortalized RPE cells by comprehensive microarray analysis...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811182/implementing-sustainable-data-collection-for-a-cardiac-outcomes-registry-in-an-australian-public-hospital
#11
Nicholas Cox, Angela Brennan, Diem Dinh, Rita Brien, Kath Cowie, Dion Stub, Christopher M Reid, Jeffrey Lefkovits
BACKGROUND: Clinical outcome registries are an increasingly vital component of ensuring quality and safety of patient care. However, Australian hospitals rarely have additional resources or the capacity to fund the additional staff time to complete the task of data collection and entry. At the same time, registry funding models do not support staff for the collection of data at the site but are directed towards the central registry tasks of data reporting, managing and quality monitoring...
March 12, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28810197/photochemical-formation-of-chitosan-stabilized-near-infrared-absorbing-silver-nanoworms-a-green-synthetic-strategy-and-activity-on-gram-negative-pathogenic-bacteria
#12
Sreekar Marpu, Samar S Kolailat, Daniel Korir, Brian L Kamras, Ratnesh Chaturvedi, Abel Joseph, Christopher M Smith, Misael C Palma, Jyoti Shah, Mohammad A Omary
A facile, single-step, non-seeded photochemical protocol for producing a new type of anisotropic silver nanostructure, "nanoworms", with curved longer dimensions and smooth, rounded edges. The nanoworms exhibit surface plasmon resonance (SPR) absorption in the near-infrared window (NIRW) region and are stabilized using biocompatible polymer chitosan, rendering biocompatibility and amplified safety for biological utility of the composition. Both NIRW-absorbing nanoworms and visible-absorbing nanospheres herein are attained exclusively by employing green chemistry principles...
August 4, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28810023/characteristics-of-preapproval-and-postapproval-studies-for-drugs-granted-accelerated-approval-by-the-us-food-and-drug-administration
#13
Huseyin Naci, Katelyn R Smalley, Aaron S Kesselheim
Importance: Drugs treating serious or life-threatening conditions can receive US Food and Drug Administration (FDA) accelerated approval based on showing an effect in surrogate measures that are only reasonably likely to predict clinical benefit. Confirmatory trials are then required to determine whether these effects translate to clinical improvements. Objective: To characterize preapproval and confirmatory clinical trials of drugs granted accelerated approval...
August 15, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28808192/classification-of-facial-wrinkles-among-chinese-women
#14
Jiechen Zhang, Wei Hou, Suying Feng, Xiangsheng Chen, Hongwei Wang
It is generally recognized that Caucasians and Asians have different skin aging features. The aim of this study was to develop a facial wrinkle grading scale for Chinese women. Standard photographs were taken of 242 Chinese women. Six sets of 0 to 9 wrinkle scales with reference photographs and descriptions were selected, including grading scales for resting and hyperkinetic crow's feet, frontalis lines, glabellar frown lines, and nasolabial folds. To identify the scale by objective quantitative measurement, skin surface measurements from the Visioscan(®) VC98 were used...
January 19, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28807362/leg-movement-tracking-in-automatic-video-based-one-leg-stance-evaluation
#15
Jacek Kawa, Paula Stępień, Wojciech Kapko, Aleksandra Niedziela, Jarosław Derejczyk
Falls are a major risk in elder population. Early diagnosis is therefore an important step towards increasing the safety of elders. One of the common diagnostic tests is the Berg Balance Scale (BBS), consisting of 14 exercises arranged from the easiest (sitting-to-standing) to the most demanding (one-leg stance). In this study a novel approach to the automatic assessment of the time in which the patient can remain in the one-leg stance position without loosing balance is introduced. The data is collected using a regular video camera...
August 3, 2017: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/28804866/virally-vectored-vaccine-delivery-medical-needs-mechanisms-advantages-and-challenges
#16
Daniel D Pinschewer
Vaccines represent one of the most successful chapters in the history of medicine. Over the past decades, the advent of recombinant cDNA technology has enabled the biomedical community to genetically engineer viruses for vaccine delivery purposes. As a starting point, this review evaluates the unmet medical needs, which drive scientists and industry to exploit such fundamentally new technology for human vaccination. The author discusses the molecular functioning, production and safety profile of replication-competent and -deficient viral vector systems, representing two fundamentally distinct classes of "genetic vaccines"...
August 14, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28804249/pacing-spikes-all-over
#17
REVIEW
Mohammed Shurrab, Teresa Pagacz, Ayelet Shauer, Ilan Lashevsky, David Newman, Eugene Crystal
Ventricular safety pacing (VSP) is used to avoid cross talk by delivering ventricular stimulus shortly after an atrial-paced event if ventricular-sensed event occurs. Although VSP is a protective feature that exists for decades in different pacing devices, there are some reports of unfavorable outcomes of this algorithm. More so, health care providers sometimes face difficulties in interpreting and dealing with VSP strips. This case report discusses an important pacemaker algorithm and encourages further attention to possible pitfalls and hence avoids unnecessary interventions...
2017: Clinical Medicine Insights. Cardiology
https://www.readbyqxmd.com/read/28802377/an-innovative-approach-to-improve-ear-nose-and-throat-surgical-access-for-remote-living-cape-york-indigenous-children
#18
Susan P Jacups, Denise Newman, Deborah Dean, Ann Richards, Kate M McConnon
INTRODUCTION: On a background of high rates of severe otitis media (OM) with associated hearing loss, children from the Torres Strait and Cape York region requiring ear, nose and throat (ENT) surgery, faced waiting times exceeding three years. After numerous clinical safety incidents were raised, indicating a failure of the current system to deliver appropriate care, the governing Hospital and Health service opted to deliver surgical care through an alternate process. ENT surgeries were performed on 16 consented children from two remote locations via the private health care system, funded by a health provider partnership...
September 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28801410/radiographic-features-of-importance-in-the-national-institute-for-occupational-safety-and-health-administered-coal-workers-health-surveillance-program-characterising-the-use-of-the-other-symbols
#19
Cara N Halldin, Janet M Hale, David J Blackley, A Scott Laney
OBJECTIVE: The National Institute for Occupation Safety and Health-administered Coal Workers' Health Surveillance Program (CWHSP) provides radiographic pneumoconiosis screening for US coal miners. Radiographs are classified by readers according to International Labour Office criteria. In addition to pneumoconiotic parenchymal and pleural lung abnormalities, readers document radiographic features of importance (other symbols). Other symbols are not meant to imply a diagnosis or interpretation but are relevant as they provide information beyond a pneumoconiosis classification for features related to dust exposure and other aetiologies...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28797353/clinical-outcomes-with-a-repositionable-self-expanding-transcatheter-aortic%C3%A2-valve%C3%A2-prosthesis-the-international-forward-study
#20
Eberhard Grube, Nicolas M Van Mieghem, Sabine Bleiziffer, Thomas Modine, Johan Bosmans, Ganesh Manoharan, Axel Linke, Werner Scholtz, Didier Tchétché, Ariel Finkelstein, Ramiro Trillo, Claudia Fiorina, Antony Walton, Christopher J Malkin, Jae K Oh, Hongyan Qiao, Stephan Windecker
BACKGROUND: Clinical outcomes in large patient populations from real-world clinical practice with a next-generation self-expanding transcatheter aortic valve are lacking. OBJECTIVES: This study sought to document the clinical and device performance outcomes of transcatheter aortic valve replacement (TAVR) with a next-generation, self-expanding transcatheter heart valve (THV) system in patients with severe symptomatic aortic stenosis (AS) in routine clinical practice...
August 15, 2017: Journal of the American College of Cardiology
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