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https://www.readbyqxmd.com/read/29156482/-how-to-reduce-the-rate-of-postoperative-complications-in-frail-patients
#1
Rudolf Mörgeli, Tobias Wollersheim, Claudia Spies, Felix Balzer, Susanne Koch, Sascha Treskatsch
Frail patients are more prone to develop complications during and after surgery. As the syndrome becomes more common, recognition and special management of frail patients in the perioperative setting is becoming crucial to improve short- and long-term outcomes. Based on current literature and guidelines, we present a compilation of strategies that could be employed to reduce postoperative complication rates in frail patients. Due to their impaired response to stressors, potential perioperative hazards to frail patients are identified and discussed...
November 2017: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/29155756/transcranial-electrical-brain-stimulation-in-alert-rodents
#2
Brita Fritsch, Anne-Kathrin Gellner, Janine Reis
Transcranial electrical brain stimulation can modulate cortical excitability and plasticity in humans and rodents. The most common form of stimulation in humans is transcranial direct current stimulation (tDCS). Less frequently, transcranial alternating current stimulation (tACS) or transcranial random noise stimulation (tRNS), a specific form of tACS using an electrical current applied randomly within a pre-defined frequency range, is used. The increase of noninvasive electrical brain stimulation research in humans, both for experimental and clinical purposes, has yielded an increased need for basic, mechanistic, safety studies in animals...
November 2, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29155660/real-time-surveillance-in-emergencies-using-the-early-warning-alert-and-response-network
#3
Kristina M Cordes, Susan T Cookson, Andrew T Boyd, Colleen Hardy, Mamunur Rahman Malik, Peter Mala, Khalid El Tahir, Marthe Everard, Mohamad Jasiem, Farah Husain
Humanitarian emergencies often result in population displacement and increase the risk for transmission of communicable diseases. To address the increased risk for outbreaks during humanitarian emergencies, the World Health Organization developed the Early Warning Alert and Response Network (EWARN) for early detection of epidemic-prone diseases. The US Centers for Disease Control and Prevention has worked with the World Health Organization, ministries of health, and other partners to support EWARN through the implementation and evaluation of these systems and the development of standardized guidance...
November 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29155557/wearable-nanoplasmonic-patch-detecting-sun-uv-exposure
#4
Jessica G Barajas-Carmona, Leydi Francisco-Aldana, Eden Morales-Narváez
Sun exposure is known to yield beneficial health outcomes, including synthesis of adequate levels of vitamin D, beneficial modulation of blood pressure and is a valuable factor in mental health care. However, the increasing incidence of sun/UV exposure-related illness, such as skin cancer, is seriously concerning public health authorities as well as the scientific community. Consequently, moderate sun/UV exposure is strongly recommended. A wearable nanoplasmonic patch whose original color changes upon sun exposure due to its UV-responsive capabilities that are visually detectable has been engineered...
November 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29154631/alertness-and-cognitive-control-testing-the-early-onset-hypothesis
#5
Darryl W Schneider
Previous research has revealed a peculiar interaction between alertness and cognitive control in selective-attention tasks: Congruency effects are larger on alert trials (on which an alerting cue is presented briefly in advance of the imperative stimulus) than on no-alert trials, despite shorter response times (RTs) on alert trials. One explanation for this finding is the early onset hypothesis, which is based on the assumptions that increased alertness shortens stimulus-encoding time and that cognitive control involves gradually focusing attention during a trial...
November 20, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/29153074/is-being-punished-at-school-an-indicator-of-psychosocial-risk
#6
Ana Isabel Corchado, María José Díaz-Aguado Jalón, Rosario Martínez-Arias
Research carried out in different cultural contexts shows that the use of exclusively coercive disciplinary measures does not improve the behavior of those punished, and may even increase the risks underpinning those behaviors. The aim of this research was to study whether there is a link between repeatedly suffering punishment at school and psychosocial risks in adolescence. A non-experimental design was implemented with selected groups. The participants were 507 adolescents from four groups with different risk levels: in social protection (n = 189); subject to court measures (n = 104); in treatment for drug abuse (n = 25); and comparison group (n = 189)...
November 20, 2017: Spanish Journal of Psychology
https://www.readbyqxmd.com/read/29152996/birth-defects-associated-with-congenital-zika-virus-infection-in-mexico
#7
Silvina Noemí Contreras-Capetillo, Nina Valadéz-González, Pablo Manrique-Saide, Rafael Eduardo Carcaño-Castillo, Freddy Pacheco-Tugores, Hirian Alonso Moshe Barrera-Pérez, Doris Pinto-Escalante, Manuel Lliteras-Cardín, José Alfredo Hoil-Parra, José Luis Cáceres-Solís, Norma Pavía-Ruz
Part of the work agenda of international health authorities is to define the clinical spectrum of the congenital Zika syndrome (CZS) in different territories. We describe the clinical variability that gave rise to the suspicion of CZS in 3 newborn patients in the south of Mexico with active transmission of Zika. All of them presented Zika RNA by reverse transcription-polymerase chain reaction and positive antibodies for IgM by enzyme-linked immunosorbent assay. None of the mothers tested positive for active viremia, only one mother had Zika-symptoms and titers of Zika-positive IgM...
November 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/29152265/hemophagocytic-syndrome-in-pregnancy-case-report-diagnosis-treatment-and-prognosis
#8
Aline Rousselin, Zarrin Alavi, Emmanuelle Le Moigne, Sarah Renard, Christophe Tremouilhac, Aurélien Delluc, Philippe Merviel
Diagnosis of hemophagocytic syndrome remains a challenge in particular during pregnancy. Concomitant presence of clinical and biological signs, for example, fever, pancytopenia, hyperferritinemia, and hypertriglyceridemia, should alert clinicians to suspect HPS and proceed to prompt treatments.
November 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29150310/zika-virus-in-french-polynesia-2013-14-anatomy-of-a-completed-outbreak
#9
REVIEW
Didier Musso, Hervé Bossin, Henri Pierre Mallet, Marianne Besnard, Julien Broult, Laure Baudouin, José Eduardo Levi, Ester C Sabino, Frederic Ghawche, Marion C Lanteri, David Baud
The Zika virus crisis exemplified the risk associated with emerging pathogens and was a reminder that preparedness for the worst-case scenario, although challenging, is needed. Herein, we review all data reported during the unexpected emergence of Zika virus in French Polynesia in late 2013. We focus on the new findings reported during this outbreak, especially the first description of severe neurological complications in adults and the retrospective description of CNS malformations in neonates, the isolation of Zika virus in semen, the potential for blood-transfusion transmission, mother-to-child transmission, and the development of new diagnostic assays...
November 14, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29149642/oxidative-stress-cell-cycle-arrest-dna-damage-and-apoptosis-in-adult-zebrafish-danio-rerio-induced-by-tris-1-3-dichloro-2-propyl-phosphate
#10
Hanyan Chen, Pingping Wang, Zhongkun Du, Guowei Wang, Shixiang Gao
Tris(1,3-dichloro-2-propyl)phosphate (TDCPP) is an additive flame retardant of high production volume, and frequently detected in biota and environment. However, knowledge on its potential risk and toxicological mechanism still remains limited. In this study, DNA damage, transcriptomic responses and biochemical changes in the liver of zebrafish (Danio rerio) induced by TDCPP were investigated. Zebrafish was exposed to 45.81μg/L (1/100 (96h-LC50)) and 229.05μg/L (1/20 (96h-LC50)) TDCPP for 7 d. The reactive oxygen species (ROS) and GSH contents, in addition to antioxidant enzyme activities in the liver changed significantly, and the mRNA levels of genes related to oxidative stress were alerted in a dose-dependent and/or sex-dependent manner after exposure to TDCPP...
November 10, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/29148311/for-which-clinical-rules-do-doctors-want-decision-support-and-why-a-survey-of-dutch-general-practitioners
#11
Stephanie Medlock, Saeid Eslami, Marjan Askari, Derk L Arts, Esther M van de Glind, Henk J Brouwer, Henk C van Weert, Sophia E de Rooij, Ameen Abu-Hanna
Despite the promise of decision support for improving care, alerts are often overridden or ignored. We evaluated Dutch general practitioners' intention to accept decision support in a proposed implementation based on clinical rules regarding care for elderly patients, and their reasons for wanting or not wanting support. We developed a survey based on literature and structured interviews and distributed it to all doctors who would receive support in the proposed implementation (n = 43), of which 65 percent responded...
November 1, 2017: Health Informatics Journal
https://www.readbyqxmd.com/read/29148058/classification-of-consumer-products-under-the-eu-clp-regulation-what-to-consider-when-caring-for-contact-dermatitis-patients
#12
REVIEW
Peter Elsner
Possibly hazardous chemical substances and mixtures need to be clearly and correctly classified and labelled, in order for their hazards to be properly identified and communicated. As dermatologists may encounter cases of harm to patients induced by chemicals, such as chemical burns, and irritant and allergic contact dermatitis, it is essential for them to be aware of the EU CLP Regulation and its potential pitfalls. Manufacturers are required by CLP to classify their products according to the rules given in the CLP Regulation...
November 17, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/29148021/routine-adoption-of-timp2-and-igfbp7-biomarkers-in-cardiac-surgery-for-early-identification-of-acute-kidney-injury
#13
Chiara Levante, Fiorenza Ferrari, Chiara Manenti, Faeq Husain-Syed, Marta Scarpa, Tommaso Hinna Danesi, Massimo De Cal, Valentina Corradi, Grazia M Virzì, Alessandra Brendolan, Federico Nalesso, Pércia Bezerra, Salvador Lopez-Giacoman, Sara Samoni, Mara Senzolo, Davide Giavarina, Loris Salvador, Raffaele Bonato, Silvia De Rosa, Enrico Rettore, Claudio Ronco
BACKGROUND AND PURPOSE: Acute Kidney Injury (AKI) is a severe complication affecting many hospitalized patients after cardiac surgery, with negative impacts on short- and long-term clinical outcomes and on healthcare costs. Recently, clinical interest has been aimed at defining and classifying AKI, identifying risk factors and developing diagnostic strategies to identify patients at risk early on. Achieving an early and accurate diagnosis of AKI is a crucial issue, because prevention and timely detection may help to prevent negative clinical outcomes and avoid AKI-associated costs...
November 16, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29147805/can-clinical-practice-indicator-relating-to-long-acting-benzodiazepine-use-in-the-elderly-be-easily-generated-in-a-hospital-setting
#14
Badria Kadri, Antonio Teixeira, Christelle Duteil, Annabelle Tan, Hélène Barreteau, Christophe Segouin, Pénélope Troude
BACKGROUND: To improve the appropriate use of long-acting benzodiazepine (la.bzd) prescriptions in the elderly, the Haute Autorité de Santé (HAS) has developed clinical practice indicators (CPI). The alert indicator (AI) evaluates the prevalence of la.bzd prescription among older people. The mastering indicator (MI) corresponds to the prevalence of elderly with a justified, i.e., appropriate, la.bzd prescription among all the elderly with la.bzd prescriptions. OBJECTIVE: The objective of this study was to test the feasibility of routine generation of CPI regarding la...
November 16, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29145107/postoperative-thoracic-hemorrhage-after-right-upper-lobectomy-with-thoracic-wall-resection-during-rivaroxaban-anticoagulant-therapy-for-deep-leg-vein-thrombosis-a-case-report
#15
Taiji Kuwata, Masatoshi Kanayama, Ayako Hirai, Shuichi Shinohara, Masaru Takenaka, Soichi Oka, Yasuhiro Chikaishi, Naoko Imanishi, Koji Kuroda, Fumihiro Tanaka
INTRODUCTION: Postoperative pulmonary embolism (PE) is the one of the most important complications after thoracic surgery. This complicatin after the surgery is often treated by new anticoaglant drug, such as rivaroxaban, which dose not need to the monitoring of blood coaglation system. We experienced postoperative bleeding case during anticoaglant therapy using rivaroxaban. PRESENTATION OF CASE: The patient underwent a right upper lobectomy with lung and chest wall resection for lung cancer...
November 11, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29145061/utility-of-electronic-aki-alerts-in-intensive-care-a-national-multicentre-cohort-study
#16
Jennifer Holmes, Gethin Roberts, John Geen, Alan Dodd, Nicholas M Selby, Andrew Lewington, Gareth Scholey, John D Williams, Aled O Phillips
BACKGROUND: Electronic AKI alerts highlight changes in serum creatinine compared to the patient's own baseline. Our aim was to identify all AKI alerts and describe the relationship between electronic AKI alerts and outcome for AKI treated in the Intensive Care Unit (ICU) in a national multicentre cohort. METHODS: A prospective cohort study was undertaken between November 2013 and April 2016, collecting data on electronic AKI alerts issued. RESULTS: 10% of 47,090 incident AKI alerts were associated with ICU admission...
October 18, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29144574/sglt-2-inhibitors-and-ketoacidosis-a-disproportionality-analysis-in-the-world-health-organization-s-adverse-drug-reactions-database
#17
Abdel Nasser Ado Moumouni, Perrine Robin, Dominique Hillaire-Buys, Jean-Luc Faillie
SGLT-2 inhibitors, also called gliflozins, are a new class of drugs used in type 2 diabetes. Since their marketing, several cases of ketoacidosis, including life-threatening conditions, were reported with their use. The objective of this study was to investigate the disproportionality of pharmacovigilance reports of ketoacidosis between gliflozins and other drugs used for type 2 diabetes. We performed a case non-case study within the World Health Organization's pharmacovigilance database, VigiBase. We selected all reports of serious adverse drug reaction associated with a glucose-lowering drug in patients aged 40 years and older, from January 2013 to March 2016...
November 16, 2017: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/29144409/how-well-can-we-extract-the-permanent-displacement-from-low-cost-mems-accelerometers
#18
Jyh Cherng Jan, Wei-An Chao, Yih-Min Wu, Chien-Chih Chen, Cheng-Horng Lin
Following the recent establishment of a high-density seismic network equipped with low-cost micro-electro-mechanical system (MEMS) P-wave-alert-device (P-Alert) by the earthquake early warning (EEW) research group at the National Taiwan University, a large quantity of strong-motion records from moderate-magnitude earthquakes (ML > 6) around Taiwan has been accumulated. Using a data preprocessing scheme to recover the dynamic average embedded within the P-Alert data, we adopted an automatic baseline correction approach for the P-Alert accelerograms to determine the coseismic deformation (Cd)...
November 16, 2017: Sensors
https://www.readbyqxmd.com/read/29144298/flood-forecasting-within-urban-drainage-systems-using-narx-neural-network
#19
Yves Abou Rjeily, Oras Abbas, Marwan Sadek, Isam Shahrour, Fadi Hage Chehade
Urbanization activity and climate change increase the runoff volumes, and consequently the surcharge of the urban drainage systems (UDS). In addition, age and structural failures of these utilities limit their capacities, and thus generate hydraulic operation shortages, leading to flooding events. The large increase in floods within urban areas requires rapid actions from the UDS operators. The proactivity in taking the appropriate actions is a key element in applying efficient management and flood mitigation...
November 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29144168/the-effects-of-extended-nap-periods-on-cognitive-physiological-and-subjective-responses-under-simulated-night-shift-conditions
#20
Jonathan Davy, Matthias Göbel
Extended nap opportunities have been effective in maintaining alertness in the context of extended night shifts (+12 h). However, there is limited evidence of their efficacy during 8-h shifts. Thus, this study explored the effects of extended naps on cognitive, physiological and perceptual responses during four simulated, 8-h night shifts. In a laboratory setting, 32 participants were allocated to one of three conditions. All participants completed four consecutive, 8-h night shifts, with the arrangements differing by condition...
November 16, 2017: Chronobiology International
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