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Federico Cacciapuoti, Valerio Massimo Magro, Michele Caturano, Diana Lama, Fulvio Cacciapuoti
Background: Ivabradine (IVA) is effective in patients with coronary artery disease (CAD) or systolic heart failure in sinus rhythm. Its action consists in reducing heart rate (HR) and improving the time of left ventricular (LV) diastolic filling. The aim of this study was to evaluate the effects of IVA added to conventional therapy on patients with diastolic heart failure (DHF) and preserved ejection fraction (HFpEF). Methods: We evaluated 25 patients with DHF in the New York Heart Association (NYHA) Class II-III and sinus rhythm...
October 2017: Journal of Cardiovascular Echography
Chi-In Lo, Yau-Huei Lai, Sheng-Nan Chang, Jen-Yuan Kuo, Ya-Ching Hsieh, Bernard E Bulwer, Chung-Lieh Hung, Hung-I Yeh
BACKGROUND: The associations among chronic health conditions, ventricular geometric alterations or cardiac contractile mechanics in different phenotypes heart failure (HF) remain largely unexplored. METHODS: We studied 438 consecutive hospitalized patients (mean age: 64.9 ± 16.6 years, 52.5% female) with or without clinical evidence of HF. We examined the associations among clinical co-morbidities, LV geometries and systolic mechanics in terms of global myocardial strains...
2017: Clinical and Experimental Hypertension: CHE
Mahdokht Rezaei, Ali Hosseinsabet
OBJECTIVE: Prediabetes is a dysglycemic state and is associated with subtle myocardial injury and dysfunction. We evaluated atrial conduction times (ACTs) and atrial electromechanical delays (EMDs) in prediabetic patients with coronary artery disease (CAD). METHODS: In the present study, we recruited 128 consecutive patient candidates (40 euglycemic, 48 prediabetic, and 40 diabetic patients) for coronary artery bypass grafting. ACTs were measured using tissue Doppler imaging (TDI)...
May 2017: Anatolian Journal of Cardiology
J Li, F Wang, N Zhang, Q He, Y-J Sun, H-Y Wang, D-M Yin
OBJECTIVE: The aim of the study is to investigate the cardiac compensatory function change in senior people with Coronary Artery Disease (CAD) by Quantitive Dobutamine Stress Echocardiography (DSE) and Tissue Doppler Imaging (TDI). PATIENTS AND METHODS: All of the 98 senior people (age >60) who were suspected to have CAD received the examination of DSE and TDI. The mean systolic peak velocity (Sa), early diastolic peak velocity (Ea) and late diastolic peak velocity (Aa) of mitral annulus were measured in a different dose of dobutamine stress...
September 2016: European Review for Medical and Pharmacological Sciences
Liam M McCormick, Patrick M Heck, Liam S Ring, Anna C Kydd, Sophie J Clarke, Stephen P Hoole, David P Dutka
BACKGROUND: Enhancement of myocardial glucose uptake may reduce fatty acid oxidation and improve tolerance to ischemia. Hyperglycemia, in association with hyperinsulinemia, stimulates this metabolic change but may have deleterious effects on left ventricular (LV) function. The incretin hormone, glucagon-like peptide-1 (GLP-1), also has favorable cardiovascular effects, and has emerged as an alternative method of altering myocardial substrate utilization. In patients with coronary artery disease (CAD), we investigated: (1) the effect of a hyperinsulinemic hyperglycemic clamp (HHC) on myocardial performance during dobutamine stress echocardiography (DSE), and (2) whether an infusion of GLP-1(7-36) at the time of HHC protects against ischemic LV dysfunction during DSE in patients with type 2 diabetes mellitus (T2DM)...
2015: Cardiovascular Diabetology
Turhan Togan, Ozgur Ciftci, Murat Gunday, Huseyin Narci, Hande Arslan
BACKGROUND: Like other acute and chronic infections, Brucella infection leads to endothelial dysfunction. Furthermore, it has been suggested that the chronic inflammatory state present in chronic infectious diseases leads to an acceleration in atherosclerosis. For the prediction of CAD, it is possible to use epicardial fat thickness (EFT) as an adjunctive marker beside the classical risk factors, as it is easily and non-invasively evaluated by transthoracic echocardiography. The purpose of this study was to investigate the presence of impaired myocardial performance as well as of increased arterial stiffness and EFT in patients who had been infected with brucellosis in the past...
April 2015: Acta Cardiologica
Dimitrios Babalis, Vlassis Tritakis, Georgios Floros, Aggeliki Mouzarou, Nikolaos Kafkas, Konstantina Bampali, Georgios Mertzanos
INTRODUCTION: The present study examined the effect of ranolazine, which acts via the mechanism of selective inhibition of late INa+, on parameters of left ventricular systolic and diastolic function in patients suffering from angiographically confirmed chronic coronary artery disease, presenting with chronic stable angina. METHODS: We studied 40 patients (age 67 ± 9 years; 30 men, 10 women) with chronic coronary artery disease who reported angina symptoms on optimal medication and who were not suitable for invasive treatment...
May 2015: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
Ahmet Gürdal, Erdem Kasikcioglu, Sertac Yakal, Zehra Bugra
OBJECTIVE: The aim of this study was to determine the impact of diabetes and diastolic dysfunction on exercise capacity in asymptomatic, normotensive patients with type 2 diabetes without coronary artery disease. METHODS: A total of 43 type 2 diabetes patients (age: 50 ± 5 years) and 20 healthy controls (age: 48 ± 4 years) were enrolled. Diastolic function was investigated by conventional pulsed-wave (PW) Doppler and tissue Doppler imaging (TDI). Exercise capacity was evaluated with cardiopulmonary exercise testing (CPET)...
May 2015: Diabetes & Vascular Disease Research
L Sun, C Ma, S Liu, L Zou, D Jia
OBJECTIVE: Non-invasive methods of coronary disease detection are immediately needed. Recent work suggested that mitral annular tissue velocity measurements could be helpful for assessing left ventricular function. We aim to determine the effect of coronary artery lesion on left ventricular function using tissue Doppler imaging (TDI), and to discuss the role of mitral annular tissue velocity in the diagnosis of coronary heart disease (CHD). PATIENTS AND METHODS: Coronary angiographic examinations were conducted for 68 patients with suspected CHD...
2014: European Review for Medical and Pharmacological Sciences
Altuğ Cincin, Kürşat Tigen, Tansu Karaahmet, Cihan Dündar, Emre Gürel, Mustafa Bulut, Murat Sünbül, Yelda Başaran
OBJECTIVE: The aim of this study was to explore right ventricular (RV) mechanical function in patients with hypertrophic cardiomyopathy (HCM) by 2-D speckle tracking echocardiography (2-D-STE). METHODS: Forty-three patients with HCM (mean age 48, 17 females) and 40 healthy subjects were consecutively included in this cross-sectional study. The diagnosis of HCM was based on the presence of typical clinical, electrocardiographic (ECG), and echocardiographic features...
July 2015: Anatolian Journal of Cardiology
Krishna K Kadappu, Liza Thomas
Tissue Doppler imaging (TDI) is a useful echocardiographic technique to evaluate global and regional myocardial systolic as well as diastolic function. It can also be used to quantify right ventricular and left atrial function. Recent studies have demonstrated its utility as a diagnostic as well as prognostic tool in different cardiac conditions including coronary artery disease, heart failure (both systolic and diastolic), valvular heart disease, cardiomyopathies as well as constrictive pericarditis. TDI measurements are also helpful to identify patients who will benefit from cardiac resynchronisation therapy...
March 2015: Heart, Lung & Circulation
Salvatore Petta, Christiano Argano, Daniela Colomba, Calogero Cammà, Vito Di Marco, Daniela Cabibi, Antonino Tuttolomondo, Giulio Marchesini, Antonio Pinto, Giuseppe Licata, Antonio Craxì
BACKGROUND & AIMS: Non-alcoholic fatty liver disease (NAFLD) has been associated with increased cardiovascular risk, including coronary artery disease and cardiac dysfunction. In addition, recent evidence highlighted the possible role of epicardial fat as a new cardiometabolic risk factor. We tested the correlation between epicardial fat, alterations in cardiac geometry and function, and severity of liver damage, in patients with biopsy-proven NAFLD. METHODS: The anthropometric, biochemical and metabolic features were recorded in 147 consecutive biopsy-proven NAFLD cases (Kleiner score)...
April 2015: Journal of Hepatology
Vincent Wu, Janice Y Chyou, Sohae Chung, Sharath Bhagavatula, Leon Axel
BACKGROUND: Measurement of mitral annulus (MA) dynamics is an important component of the evaluation of left ventricular (LV) diastolic function; MA velocities are commonly measured using tissue Doppler imaging (TDI). This study aimed to examine the clinical potential of a semi-automated cardiovascular magnetic resonance (CMR) technique for quantifying global LV diastolic function, using 3D volume tracking of the MA with conventional cine-CMR images. METHODS: 124 consecutive patients with normal ejection fraction underwent both clinically indicated transthoracic echocardiography (TTE) and CMR within 2 months...
September 20, 2014: Journal of Cardiovascular Magnetic Resonance
A Zagatina, O Guseva, S Y Bartosh-Zelenaya, N Zhuravskaya
AIM: Ischemic segments cannot develop a sufficient amount of strength during systole, so theoretically they begin to contract later in comparison with non-ischemic zones. There is a lack of information about methods that can detect dyssynchrony during exercise in patients with QRS not longer 100 ms. The aim of the study was to compare different methods of detection regarding left ventricular moving dyssynchrony in patients with significant coronary stenosis artery lesions: pulsed-wave of PW-TDI, strain (S) and strain rate (SR)...
April 2014: Minerva Cardioangiologica
Nashmil Hashemi, Bassem A Samad, Anders Hedman, Lars-Åke Brodin, Mahbubul Alam
AIMS: Myocardial performance index (MPI) is a measure of combined systolic and diastolic myocardial function. In patients with coronary artery disease (CAD) an increase in MPI is consistent with myocardial dysfunction. The objectives of this study were to characterize the changes in MPI after coronary artery bypass graft (CABG) at rest and at peak dobutamine stress echocardiography (DSE). METHODS AND RESULTS: Thirty-six patients diagnosed with CAD and accepted for CABG were studied by standard echocardiography and DSE 1 month prior and 3 month after CABG...
September 2014: Echocardiography
Barış Güngör, Hale Yılmaz, Ahmet Ekmekçi, Kazım Serhan Özcan, Mohamedou Tijani, Damirbek Osmonov, Baran Karataş, Ahmet Taha Alper, Ferit Onur Mutluer, Ufuk Gürkan, Osman Bolca
BACKGROUND: Atherosclerosis and arterial stiffening may coexist and the correlation of these parameters in patients with premature coronary artery disease (CAD) has not been well elucidated. Tissue Doppler imaging of the ascending aorta may be used in the assessment of elastic properties of the great arteries. OBJECTIVE: To investigate the correlation between aortic stiffness and premature CAD using parameters derived from two-dimensional and tissue Doppler imaging (TDI) echocardiography of the ascending aorta...
March 2014: Journal of Cardiology
Frank Lloyd Dini, Maurizio Galderisi, Stefano Nistri, Simona Buralli, Piercarlo Ballo, Donato Mele, Luigi Paolo Badano, Pompilio Faggiano, Cesare de Gregorio, Gian Marco Rosa, Massimo Ciavarella, Eugenia De Marco, Enzo Borruso, Giuliano Marti, Sergio Mondillo, Paolo Nicola Marino
BACKGROUND: Through integrated use of echo-Doppler and tissue Doppler imaging (TDI), it is possible to obtain a comprehensive evaluation of both left ventricular (LV) diastolic and longitudinal functions. In this study, we sought to assess the prevalence of LV diastolic dysfunction (LVDD) and its relation with indices of long-axis function in asymptomatic patients with arterial hypertension. METHODS AND RESULTS: A perspective echo-Doppler study was performed in 1556 consecutive asymptomatic patients with grade 2-to-3 arterial hypertension aged 40-80 years enrolled in the SPHERE (multicenter proSPective study of ecHocardiography in hypERtEnsion) study...
October 9, 2013: International Journal of Cardiology
Rajender Agarwal, Priyanka Gosain, James N Kirkpatrick, Tareq Alyousef, Rami Doukky, Gurpreet Singh, Craig A Umscheid
Global and regional left ventricular (LV) systolic dysfunction is a marker of coronary artery disease (CAD), which is conventionally assessed using two-dimensional echocardiography. Tissue Doppler imaging (TDI) has emerged as an adjunct tool in the diagnosis of regional wall motion abnormalities from CAD. We performed a systematic review and meta-analysis to assess the efficacy of TDI indices in the diagnosis of CAD. We searched MEDLINE and the Cochrane Library for controlled studies comparing TDI measurements in those with and without CAD as confirmed by coronary angiography...
November 30, 2012: Cardiovascular Ultrasound
Ahmet Bacaksiz, Mehmet Kayrak, Mehmet Akif Vatankulu, Selim S Ayhan, Osman Sonmez, Hakan Akilli, Alpay Aribas, Hatem Ari, Kurtulus Ozdemir
BACKGROUND: Cigarette smoking is associated with increased rates of coronary artery disease and acute myocardial infarction (MI). Paradoxically, smokers had lower mortality after MI. The purpose of this study was to evaluate the effect of chronic smoking on myocardial performance index (MPI) in middle-aged men after an acute MI. MATERIAL AND METHODS: A total of 429 patients (325 smokers vs. 104 nonsmokers) presenting with acute ST elevation MI were enrolled in this study...
February 2013: Echocardiography
Muhammad-Mujtaba Ali Siddiqui, Anjum Jalal, Mubashir Sherwani, Muhammad Zubair Ahmad
OBJECTIVE: To evaluate the impact of coronary bypass surgery on the function of the right ventricle (RV) in patients with a pre-operative ejection fraction ≥ 35% who did not have any perioperative myocardial infarction. METHOD: We performed a prospective study of 30 patients who underwent uneventful isolated coronary artery bypass grafting (CABG). All patients had echocardiography prior to surgery and 3 months postoperatively. Myocardial tissue Doppler velocities were used to measure left and right ventricular function...
August 2012: Heart Surgery Forum
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