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https://www.readbyqxmd.com/read/27928465/gene-expression-and-pathway-analysis-of-ctnnb1-in-cancer-and-stem-cells
#1
Shihori Tanabe, Takeshi Kawabata, Kazuhiko Aoyagi, Hiroshi Yokozaki, Hiroki Sasaki
AIM: To investigate β-catenin (CTNNB1) signaling in cancer and stem cells, the gene expression and pathway were analyzed using bioinformatics. METHODS: The expression of the catenin β 1 (CTNNB1) gene, which codes for β-catenin, was analyzed in mesenchymal stem cells (MSCs) and gastric cancer (GC) cells. Beta-catenin signaling and the mutation of related proteins were also analyzed using the cBioPortal for Cancer Genomics and HOMology modeling of Complex Structure (HOMCOS) databases...
November 26, 2016: World Journal of Stem Cells
https://www.readbyqxmd.com/read/27899328/the-s48-45-six-cysteine-proteins-mediators-of-interaction-throughout-the-plasmodium-life-cycle
#2
REVIEW
Silvia A Arredondo, Stefan H I Kappe
During their life cycle Plasmodium parasites rely upon an arsenal of proteins that establish key interactions with the host or vector, and between the parasite sexual stages, with the purpose of ensuring infection, reproduction and proliferation. Among these is a group of secreted or membrane-anchored proteins known as the six-cysteine (6-cys) family. This is a small but important family with only 14 members thus far identified, each stage-specifically expressed during the parasite life cycle. 6-cys proteins often localise at the parasite surface or interface with the host and are conserved in different Plasmodium species...
November 27, 2016: International Journal for Parasitology
https://www.readbyqxmd.com/read/27887627/epha5-protein-a-potential-marker-for-distinguishing-histological-grade-and-prognosis-in-ovarian-serous-carcinoma
#3
Xiao Chen, Xuan Wang, Xue Wei, Jiandong Wang
BACKGROUND: Ovarian serous carcinoma (OSC) is the most common ovarian epithelial malignancy. Disregulation of Eph/ephrin signaling has been implicated in oncogenesis and tumor progression. EphA5 receptor is one of large families of Eph tyrosine kinase receptor and is documented in the development of nervous system. Till now, there is no published data about the role of EphA5 in ovarian epithelial neoplasmas. METHODS: This study aims to investigate the expression of EphA5 protein in ovarian serous carcinoma, and its relationship to clinical pathological characteristics...
November 25, 2016: Journal of Ovarian Research
https://www.readbyqxmd.com/read/27861585/cdc-42-orients-cell-migration-during-epithelial-intercalation-in-the-caenorhabditis-elegans-epidermis
#4
Elise Walck-Shannon, Bethany Lucas, Ian Chin-Sang, David Reiner, Kraig Kumfer, Hunter Cochran, William Bothfeld, Jeff Hardin
Cell intercalation is a highly directed cell rearrangement that is essential for animal morphogenesis. As such, intercalation requires orchestration of cell polarity across the plane of the tissue. CDC-42 is a Rho family GTPase with key functions in cell polarity, yet its role during epithelial intercalation has not been established because its roles early in embryogenesis have historically made it difficult to study. To circumvent these early requirements, in this paper we use tissue-specific and conditional loss-of-function approaches to identify a role for CDC-42 during intercalation of the Caenorhabditis elegans dorsal embryonic epidermis...
November 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27811149/eph-receptor-tyrosine-kinases-in-tumor-immunity
#5
REVIEW
Eileen Shiuan, Jin Chen
The family of Eph receptor tyrosine kinases and their ephrin ligands regulate a diverse array of physiologic processes, such as axonal guidance, bone remodeling, and immune cell development and trafficking. Eph/ephrin interactions have also been implicated in various pathologic processes, including inflammation, cancer, and tumor angiogenesis. Because Eph receptors play prominent roles in both the immune system and cancer, they likely impact the tumor immune microenvironment, an area in which Eph receptors remain understudied...
November 3, 2016: Cancer Research
https://www.readbyqxmd.com/read/27804871/the-sam-domain-of-epha2-receptor-and-its-relevance-to-cancer-a-novel-challenge-for-drug-discovery
#6
Flavia Mercurio, Marilisa Leone
BACKGROUND: Eph receptors play important functions in developmental processes and diseases and among them EphA2 is well known for its controversial role in cancer. Drug discovery strategies are mainly centered on EphA2 extracellular ligand-binding domain however, the receptor also contains a largely unexplored cytosolic Sam (Sterile alpha motif) domain at the C-terminus. EphA2-Sam binds the Sam domain from the lipid phosphatase Ship2 and the first Sam domain of Odin. Sam-Sam interactions may be important to regulate ligand-induced receptor endocytosis and degradation i...
November 1, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27788485/the-intrinsically-kinase-inactive-ephb6-receptor-predisposes-cancer-cells-to-dr5-induced-apoptosis-by-promoting-mitochondrial-fragmentation
#7
Amr M El Zawily, Behzad M Toosi, Tanya Freywald, Vijaya V Indukuri, Franco J Vizeacoumar, Scot C Leary, Andrew Freywald
Death Receptor 5 (DR5) is a promising target for cancer therapy due to its ability to selectively induce apoptosis in cancer cells. However, the therapeutic usefulness of DR5 agonists is currently limited by the frequent resistance of malignant tumours to its activation. The identification of molecular mechanisms that determine outcomes of DR5 action is therefore crucial for improving the efficiency of DR5-activating reagents in cancer treatment. Here, we provide evidence that an intrinsically kinase-inactive member of the Eph group of receptor tyrosine kinases, EPHB6, induces marked fragmentation of the mitochondrial network in breast cancer cells of triple-negative origin, lacking expression of the estrogen, progesterone and HER2 receptors...
October 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27783670/dual-microrna-screens-reveal-that-the-immune-responsive-mir-181-promotes-henipavirus-entry-and-cell-cell-fusion
#8
Chwan Hong Foo, Christina L Rootes, Karla Cowley, Glenn A Marsh, Cathryn M Gould, Celine Deffrasnes, Christopher J Cowled, Reuben Klein, Sarah J Riddell, Deborah Middleton, Kaylene J Simpson, Lin-Fa Wang, Andrew G D Bean, Cameron R Stewart
Hendra and Nipah viruses (family Paramyxoviridae, genus Henipavirus) are bat-borne viruses that cause fatal disease in humans and a range of other mammalian species. Gaining a deeper understanding of host pathways exploited by henipaviruses for infection may identify targets for new anti-viral therapies. Here we have performed genome-wide high-throughput agonist and antagonist screens at biosafety level 4 to identify host-encoded microRNAs (miRNAs) impacting henipavirus infection in human cells. Members of the miR-181 and miR-17~93 families strongly promoted Hendra virus infection...
October 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27776928/the-sam-domain-inhibits-epha2-interactions-in-the-plasma-membrane
#9
Deo R Singh, Fozia Ahmed, Michael D Paul, Manasee Gedam, Elena B Pasquale, Kalina Hristova
All members of the Eph receptor family of tyrosine kinases contain a SAM domain near the C terminus, which has been proposed to play a role in receptor homotypic interactions and/or interactions with binding partners. The SAM domain of EphA2 is known to be important for receptor function, but its contribution to EphA2 lateral interactions in the plasma membrane has not been determined. Here we use a FRET-based approach to directly measure the effect of the SAM domain on the stability of EphA2 dimers on the cell surface in the absence of ligand binding...
January 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27756445/effect-of-task-specific-training-on-eph-ephrin-expression-after-stroke
#10
Dong-Hee Choi, Jin-Hee Ahn, In-Ae Choi, Ji-Hye Kim, Bo-Ram Kim, Jongmin Lee
Recent evidence indicates that the ephrin receptors and ephrin ligands (Eph/ephrin) expression modulates axonal reorganization and synaptic plasticity in stroke recovery. To investigate the effect of task-specific training (TST) on Eph/ephrin expression in the corticospinal tract (CST) after stroke, we compared Eph/ephrin expression in the peri-infarct cortex, pyramid, and spinal cord of the photothrombotic stroke rats treated with or without TST. The TST treatment showed significantly better recovery in the behavioral tests...
October 19, 2016: BMB Reports
https://www.readbyqxmd.com/read/27693790/epha7-modulates-apical-constriction-of-hindbrain-neuroepithelium-during-neurulation-in-xenopus
#11
Xiaolei Wang, Jian Sun, Chaocui Li, Bingyu Mao
Eph receptor tyrosine kinases (RTKs) and their ephrin ligands play multiple roles in the developing nervous system, including cell segregation, axon guidance and synaptic plasticity. Here we report the expression and function of EphA7 in Xenopus hindbrain development. EphA7 is specifically expressed in the hindbrain throughout neurulation in Xenopus embryos. Knockdown of EphA7 by specific morpholino oligonucleotide (MO) disrupted cranial neural tube closure and disturbed apical constriction of hindbrain neuroepithelial cells, indicating weakened cell surface tension...
October 28, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27681698/association-between-polymorphisms-of-ogg1-epha2-and-age-related-cataract-risk-a-meta-analysis
#12
Hongxu Zhang, Jianguang Zhong, Zhenyu Bian, Xiang Fang, You Peng, Yongping Hu
BACKGROUND: Evidences have identified the correlation of 8-oxoguanine DNA glycosylase-1 (OGG1) and eph-receptor tyrosine kinase-type A2 (EPHA2) polymorphisms in age-related cataract (ARC) risk. However, the results were not consistent. The objective of this study was to examine the role of these two gene polymorphisms in ARC susceptibility. METHODS: Eligible case-control studies published between January 2000 and 2015 were searched and retrieved in the electronic databases...
September 29, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27651378/reduced-expression-of-epha5-is-associated-with-lymph-node-metastasis-advanced-tnm-stage-and-poor-prognosis-in-colorectal-carcinoma
#13
Shudong Gu, Jia Feng, Qin Jin, Wei Wang, Shu Zhang
Colorectal carcinoma (CRC) is the third most common cancer and a major cause of morbidity and mortality throughout the world. The prognosis of patients has improved markedly over the last 15 years because of the introduction of new therapy including molecular target drugs. To comprehensively understand the molecular process of carcinogenesis of colorectal carcinoma is essential for the diagnosis, prognosis and treatment. EphA5 is a member of the Eph family and plays a critical role in carcinogenesis of lung cancer, prostate cancer, and breast cancer...
September 21, 2016: Histology and Histopathology
https://www.readbyqxmd.com/read/27602130/hsa-mir-137-hsa-mir-520e-and-hsa-mir-590-3p-perform-crucial-roles-in-lynch-syndrome
#14
Changyu Zhou, Jiayu Li, Jiarui Li, Yingchun Wan, Tao Li, Piyong Ma, Yingjian Wang, Haiyan Sang
The aim of the present study was to identify the differentially expressed microRNAs (DEMs) between Lynch syndrome (LS) and the normal colonic (N-C) control samples, predict the target genes (TGs) and analyze the potential functions of the DEMs and TGs. The miRNA expression dataset GSE30454, which included data of 13 LS and 20 N-C tissue samples, was downloaded from the Gene Expression Omnibus. The classical t-test in Linear Models for Microarray Data package was used for DEM identification. TG prediction was performed using 5 databases...
September 2016: Oncology Letters
https://www.readbyqxmd.com/read/27597758/tiam-rac-signaling-mediates-trans-endocytosis-of-ephrin-receptor-ephb2-and-is-important-for-cell-repulsion
#15
Thomas N Gaitanos, Jorg Koerner, Ruediger Klein
Ephrin receptors interact with membrane-bound ephrin ligands to regulate contact-mediated attraction or repulsion between opposing cells, thereby influencing tissue morphogenesis. Cell repulsion requires bidirectional trans-endocytosis of clustered Eph-ephrin complexes at cell interfaces, but the mechanisms underlying this process are poorly understood. Here, we identified an actin-regulating pathway allowing ephrinB(+) cells to trans-endocytose EphB receptors from opposing cells. Live imaging revealed Rac-dependent F-actin enrichment at sites of EphB2 internalization, but not during vesicle trafficking...
September 12, 2016: Journal of Cell Biology
https://www.readbyqxmd.com/read/27591824/loss-of-epha3-protein-expression-is-associated-with-advanced-tnm-stage-in-clear-cell-renal-cell-carcinoma
#16
Xiaolin Wang, Haifei Xu, Guangxin Cao, Zhijun Wu, Jiandong Wang
BACKGROUND: Erythropoietin-producing hepatocellular carcinoma (Eph) receptors constitute the largest family of receptor tyrosine kinases. Ephs and their ligands ephrins play an important role in development and carcinogenesis. The expression of EphA3, an Eph family member, has been investigated in a variety of human cancers, with mixed results. High levels of EphA3 protein expression have been reported in colorectal, prostate, and gastric cancers, whereas loss of protein expression has been reported in lung and hematopoietic cancers...
August 8, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27566654/epha7-and-epha10-physically-interact-and-differentially-co-localize-in-normal-breast-and-breast-carcinoma-cell-lines-and-the-co-localization-pattern-is-altered-in-ephb6-expressing-mda-mb-231-cells
#17
Candace Johnson, Briana Segovia, Raj P Kandpal
Erythropoietin-producing hepatocellular carcinoma cell (EPH) receptors comprise the most abundant receptor tyrosine kinase family characterized to date in mammals including humans. These proteins are involved in axon guidance, tissue organization, vascular development and the intricate process of various diseases including cancer. These diverse functions of EPH receptors are attributed, in part, to their abilities for heterodimerization. While the interacting partners of kinase-deficient EPHB6 receptor have been characterized, the interaction of the kinase-dead EPHA10 with any other receptor has not been identified...
September 2016: Cancer Genomics & Proteomics
https://www.readbyqxmd.com/read/27565439/eph-receptor-interclass-cooperation-is-required-for-the-regulation-of-cell-proliferation
#18
Aleksandra Jurek, Maria Genander, Parag Kundu, Timothy Catchpole, Xiao He, Klas Strååt, Hanna Sabelström, Nan-Jie Xu, Sven Pettersson, Mark Henkemeyer, Jonas Frisén
Cancer often arises by the constitutive activation of mitogenic pathways by mutations in stem cells. Eph receptors are unusual in that although they regulate the proliferation of stem/progenitor cells in many adult organs, they typically fail to transform cells. Multiple ephrins and Eph receptors are often co-expressed and are thought to be redundant, but we here describe an unexpected dichotomy with two homologous ligands, ephrin-B1 and ephrin-B2, regulating specifically migration or proliferation in the intestinal stem cell niche...
October 15, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/27553867/ephb4-a-down-stream-target-of-ifn-%C3%AE-stat1-signal-pathway-regulates-endothelial-activation-possibly-contributing-to-the-development-of-preeclampsia
#19
Xiaoping Liu, Ying Hu, Xiaoxia Liu, Yanfang Zheng, Minglian Luo, Weifang Liu, Yin Zhao, Li Zou
PROBLEM: Preeclampsia is characterized by endothelial activation and excessive inflammation, of which interferon (IFN)-γ is a potent inducer. Eph receptor B4 (EPHB4) also involved in endothelial activation in inflammation. Their role and relationship in preeclampsia remain unclear. METHOD OF STUDY: Intercellular adhesion molecular (ICAM)-1 was employed as the hallmark of endothelial activation. The serum levels of IFN-γ and the expression of EPHB4 and ICAM-1 were assessed by ELISA, qRT-PCR and WB, respectively...
October 2016: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/27549114/inhibition-of-epha2-ephrina1-signal-attenuates-lipopolysaccharide-induced-lung-injury
#20
Ji Young Hong, Mi Hwa Shin, Ivor S Douglas, Kyung Soo Chung, Eun Young Kim, Ji Ye Jung, Young Ae Kang, Se Kyu Kim, Joon Chang, Young Sam Kim, Moo Suk Park
Eph-Ephrin signalling mediates various cellular processes, including vasculogenesis, angiogenesis, cell migration, axon guidance, fluid homoeostasis and repair after injury. Although previous studies have demonstrated that stimulation of the EphA receptor induces increased vascular permeability and inflammatory response in lung injury, the detailed mechanisms of EphA2 signalling are unknown. In the present study, we evaluated the role of EphA2 signalling in mice with lipopolysaccharide (LPS)-induced lung injury...
November 1, 2016: Clinical Science (1979-)
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