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https://www.readbyqxmd.com/read/28635197/depression-anxiety-and-chronic-pain-in-patients-with-chronic-obstructive-pulmonary-disease-the-influence-of-breath
#1
Bruno Bordoni, Fabiola Marelli, Bruno Morabito, Beatrice Sacconi
Chronic obstructive pulmonary disease (COPD) is a major public health problems, causing significant mortality and morbidity in the world. It is a complex and progressive disease, characterized by chronic inflammation and dysfunction of the respiratory airways. The article reviews the available information on the potential role of the diaphragm in this disease. The purpose is to identify a potential correlation between symptoms such as depression, anxiety and chronic pain, frequently observed in COPD, with the activity of the diaphragm...
May 25, 2017: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/28633384/correlates-of-dyspnoea-and-its-association-with-adverse-outcomes-in-a-cohort-of-adults-aged-80-and-over
#2
Eralda Hegendörfer, Bert Vaes, Catharina Matheï, Gijs Van Pottelbergh, Jean-Marie Degryse
Background: adults aged 80 and over, a fast growing age-group, with increased co-morbidity and frailty have not been the focus of previous research on dyspnoea. We investigate the correlates of dyspnoea and its association with adverse outcomes in a cohort of adults aged 80 and over. Methods: about 565 community-dwelling adults aged 80 and over of the BELFRAIL prospective cohort had assessment of Medical Research Council dyspnoea scale (MRC), forced expiratory volume in 1 s (FEV1), N-terminal pro-brain natriuretic peptide (NT-proBNP), physical performance tests, grip strength, 15 items geriatric depression scale, activities of daily living (ADL), body mass index (BMI) and demographics data...
June 14, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28631453/propofol-dexmedetomidine-versus-propofol-remifentanil-conscious-sedation-for-awake-craniotomy-during-epilepsy-surgery
#3
Abd-Elazeem Elbakry, Ezzeldin Ibrahim
BACKGROUND: Conscious sedation during awake craniotomy requires balanced anaesthesia technique to achieve optimum sedation and analgesia. This technique should be done without causing respiratory depression or loss of consciousness. The present study aims at evaluating the effect of propofol-dexmedetomidine versus propofol-remifentanil conscious sedation during awake craniotomy for epilepsy surgery. METHODS: Sixty patients undergoing awake craniotomy for epilepsy surgery were randomly divided into two groups, PD group and PR group...
June 14, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28629514/erythropoietin-mediated-regulation-of-central-respiratory-command
#4
Tommy Seaborn, Céline Caravagna
Erythropoietin (Epo) is a cytokine expressed throughout the body, including in the central nervous system where it can act as a breathing modulator in the central respiratory network. In vitro, Epo allows maintaining the activity of respiratory neurons during acute hypoxia, resulting in inhibition of the hypoxia-induced rhythm depression. In vivo, Epo action on the central respiratory command results in enhancement of the acute hypoxic ventilatory response, allowing a better oxygenation of the body by improvement of gases exchanges in the lungs...
2017: Vitamins and Hormones
https://www.readbyqxmd.com/read/28627976/administration-of-rocuronium-based-on-real-body-weight-versus-fat-free-mass-in-patients-with-lymphedema
#5
Zhang Jing, Aikeremujiang Muheremu, Pengfei Liu, Xiaoyun Hu, Zhao Binjiang
Objective To compare the clinical pharmacokinetics of rocuronium when applied according to fat-free mass versus real body weight during anesthetic induction of patients with lymphedema. Methods Sixty patients with lymphedema (age, 18-60 years; American Society of Anesthesiologists physical status, I-II) undergoing elective surgery with general anesthesia were randomly divided into two groups. Rocuronium was administered based on the fat-free mass in 30 patients and real body weight in 30 patients. General anesthesia was induced with propofol and remifentanil by target-controlled infusion...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28625303/parenteral-opioid-analgesia-does-it-still-have-a-role
#6
REVIEW
Sioned Nesta Phillips, Roshan Fernando, Thierry Girard
Parenteral opioids have been used in labour analgesia for many years, but the ideal opioid in this setting is yet to be found. We review the properties of currently used opioids, their analgesic properties and side effects to mother and foetus. Parenteral opioids can be administered as intermittent boluses or through a patient-controlled intravenous administration system. A wide range of opioid drugs are currently used and provide a variable degree of analgesia. All opioids can cause unwanted maternal side effects such as nausea, vomiting, sedation and respiratory depression...
March 2017: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/28623944/the-effect-of-combining-manual-therapy-with-exercise-for-mild-chronic-obstructive-pulmonary-disease-study-protocol-for-a-randomised-controlled-trial
#7
Roger M Engel, Jaxson Wearing, Peter Gonski, Subramanyam Vemulpad
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a major cause of disability and hospital admission. Current management strategies have not been successful in altering the loss of lung function typically seen as the disease progresses. A recent systematic review into the use of spinal manipulative therapy (SMT) in the management of COPD concluded that there was low level evidence to support the view that a combination of SMT and exercise had the potential to improve lung function more than exercise alone in people with moderate to severe COPD...
June 17, 2017: Trials
https://www.readbyqxmd.com/read/28622694/the-effect-of-intraperitoneal-chemotherapy-on-early-pain-hyperalgesia-in-patients-following-elective-laparoscopic-transabdominal-resection-of-rectal-cancer
#8
Min Liang, Chang-Ying Li, Chun-Guang Ren, Zong-Wang Zhang, Zhi-Jian Fu
BACKGROUND: Chemotherapy has been associated with hyperalgesia. This prospective study was designed to investigate the effect of intraperitoneal chemotherapy with lobaplatin on post-operative pain intensity and sufentanil requirements after laparoscopic transabdominal resection of rectal cancer. METHODS: Eighty subjects (40 subjects treated with intraperitoneal chemotherapy and 40 subjects without chemotherapy treatment) scheduled for laparoscopic transabdominal resection of rectal cancer were included in this study...
June 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28610672/agoraphobic-avoidance-predicts-emotional-distress-and-increased-physical-concerns-in-chronic-obstructive-pulmonary-disease
#9
Pawel Holas, Jaroslaw Michałowski, Łukasz Gawęda, Joanna Domagała-Kulawik
BACKGROUND: Anxiety and panic attacks are more common in chronic obstructive pulmonary disease (COPD) than in the overall population. Individuals with panic attacks often attempt to avoid situations perceived as at risk of eliciting bodily sensations such as dyspnea, which paradoxically may lead to anxiety-related responsivity. Although there is some evidence that COPD individuals restrict their participation in various life activities because they fear that these may trigger breathlessness, little is known about agoraphobic avoidance and its impact on cognitions and emotional distress in this population...
July 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28607333/the-impact-of-dexmedetomidine-or-xylocaine-continuous-infusion-on-opioid-consumption-and-quality-of-recovery-following-laparoscopic-sleeve-gastrectomy-a-randomized-double-blinded-controlled-study
#10
Abeer A Sherif, Hazem E Elsersy
BACKGROUND: Postoperative pain control for morbidly obese patients represents a challenge because of their sensitivity towards opioid-induced respiratory depression. We elected both dexmedetomidine and xylocaine (lidocaine) continuous infusions as adjuvants because they lack respiratory depression side effect. METHODS: 150 ASA I to III patients were enrolled in the study, randomly allocated into three equal parallel groups; the control, lidocaine or dexmedetomidine group...
June 12, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28606595/a-multisite-retrospective-study-evaluating-the-implementation-of-the-pasero-opioid-induced-sedation-scale-poss-and-its-effect-on-patient-safety-outcomes
#11
Christie Davis, Christopher Geik, Karen Arthur, James Fuller, Elizabeth Johnston, Francesca Levitt, Edward Leung, Gregory McCart, Derek McMichael, Julie Painter, Therese Staublin, Todd Walroth
The Joint Commission recommended the Pasero Opioid-induced Sedation Scale (POSS) to minimize opioid-induced respiratory depression. However, there is a paucity of data describing its impact on patient safety. This study assessed the impact of POSS implementation or reeducation on naloxone use in patients receiving hydromorphone. This retrospective, Institutional Review Board-approved study performed with the Indianapolis Coalition for Patient Safety was conducted in two phases, 3 months before and after intervention...
June 9, 2017: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://www.readbyqxmd.com/read/28603562/meditation-in-stressed-older-adults-improvements-in-self-rated-mental-health-not-paralleled-by-improvements-in-cognitive-function-or-physiological-measures
#12
Barry S Oken, Helané Wahbeh, Elena Goodrich, Daniel Klee, Tabatha Memmott, Meghan Miller, Rongwei Fu
To determine if mindfulness meditation (MM) in older adults improves cognition and, secondarily, if MM improves mental health and physiology, 134 at least mildly stressed 50-85 year olds were randomized to a six-week MM intervention or a waitlist control. Outcome measures were assessed at baseline and two months later at Visit 2. The primary outcome measure was an executive function/attentional measure (flanker task). Other outcome measures included additional cognitive assessments, salivary cortisol, respiratory rate, heart rate variability, Positive and Negative Affect Schedule (PANAS), Center for Epidemiologic Studies Depression (CESD), Perceived Stress Scale (PSS), Neuroticism-Extraversion-Openness (NEO) personality traits, and SF-36 health-related quality of life...
June 2017: Mindfulness
https://www.readbyqxmd.com/read/28602061/factors-associated-with-low-level-physical-activity-in-elderly-patients-with-chronic-obstructive-pulmonary-disease
#13
Sang Hee Lee, Ki Uk Kim, Haejung Lee, Yun Seong Kim, Min Ki Lee, Hye-Kyung Park
Background/Aims: In patients with chronic obstructive pulmonary disease (COPD), the extent of physical activity (PA) is correlated with disease severity and prognosis. However, factors associated with low-level PA in elderly COPD patients are not known. We assessed the levels of PA and clinical factors associated with low-level of PA in elderly COPD patients. Methods: This was a secondary analysis of a multicenter, prospective study of 245 patients with COPD. Among them, 160 patients with 65 years or more were included...
June 7, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28601985/poor-early-childhood-outcomes-attributable-to-maternal-depression-in-mexican-women
#14
Filipa de Castro, Jean Marie Place, Aremis Villalobos, Rosalba Rojas, Tonatiuh Barrientos, Edward A Frongillo
We aimed to estimate the population fraction of poor early child health and developmental outcomes attributable to maternal depressive symptoms (DS) contrasting it between low- and middle/high-income households. We used a nationally representative probabilistic sample of 4240 children younger than 5 years old and their mothers, derived from the Mexican National Health and Nutrition Survey Data (ENSANUT 2012). Complex survey design, sampling, and analytic weights were taken into account in analyses. DS was measured by CESD-7...
June 10, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/28601836/contextual-and-individual-inequalities-of-multimorbidity-in-brazilian-adults-a-cross-sectional-national-based-study
#15
Bruno P Nunes, Alexandre D P Chiavegatto Filho, Sanghamitra Pati, Doralice S Cruz Teixeira, Thaynã R Flores, Fabio A Camargo-Figuera, Tiago N Munhoz, Elaine Thumé, Luiz A Facchini, Sandro R Rodrigues Batista
OBJECTIVES: The study aims to evaluate the magnitude of multimorbidity in Brazilian adults, as well to measure their association with individual and contextual factors stratified by Brazilian states and regions. METHODS: A national-based cross-sectional study was carried out in 2013 with Brazilian adults. Multimorbidity was evaluated by a list of 22 physical and mental morbidities (based on self-reported medical diagnosis and Patient Health Questionnaire-9 for depression)...
June 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/28600701/the-impact-of-exposure-to-antidepressant-medications-during-pregnancy-on-neonatal-outcomes-a-review-of-retrospective-database-cohort-studies
#16
REVIEW
Casey R Tak, Kathleen M Job, Katie Schoen-Gentry, Sarah C Campbell, Patrick Carroll, Maged Costantine, Diana Brixner, Angela K Birnbaum, Catherine M T Sherwin
INTRODUCTION: Concerns with prescription antidepressant use in pregnant women have instigated the examination of potential associations between fetal exposure to antidepressant medication and outcomes including preterm delivery, congenital malformations, perinatal and post-natal adverse events, persistent pulmonary hypertension, and mortality. The retrospective cohort model is an often utilized study design. The objective of this review is to evaluate the literature on antidepressant use in pregnancy conducted as retrospective cohorts in national/regional medical, or claims databases that assess neonatal and infant outcomes for agreement between studies, ultimately providing a methodological and outcomes summary for future scientific endeavors...
June 9, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28598927/intraoperative-analgesia-nociception-index-guided-fentanyl-administration-during-sevoflurane-anesthesia-in-lumbar-discectomy-and-laminectomy-a-randomized-clinical-trial
#17
Henry D Upton, Guy L Ludbrook, Andrew Wing, Jamie W Sleigh
BACKGROUND: The "Analgesia Nociception Index" (ANI; MetroDoloris Medical Systems, Lille, France) is a proposed noninvasive guide to analgesia derived from an electrocardiogram trace. ANI is scaled from 0 to 100; with previous studies suggesting that values ≥50 can indicate adequate analgesia. This clinical trial was designed to investigate the effect of intraoperative ANI-guided fentanyl administration on postoperative pain, under anesthetic conditions optimized for ANI functioning...
July 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28594145/use-of-antidepressant-medication-in-pregnancy-and-adverse-neonatal-outcomes-a-population-based-investigation
#18
Anna Cantarutti, Luca Merlino, Carlo Giaquinto, Giovanni Corrao
BACKGROUND: Untreated depression and antidepressant use during pregnancy may have negative consequences for births. There are still conflicting data on the potential harmful effects of prenatal antidepressant treatment on child health. OBJECTIVE: To investigate the relationship between the use of antidepressant medication during pregnancy and selected neonatal outcomes. METHODS: A population-based cohort study including 9825 deliveries exposed to an antidepressant between 9 months before last menstrual date through to delivery, from January 2005 to December 2010 in the Lombardy region of Italy, was conducted...
June 8, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28593192/intravenous-heroin-induces-rapid-brain-hypoxia-and-hyperglycemia-that-precede-brain-metabolic-response
#19
Ernesto Solis, Keaton T Cameron-Burr, Yavin Shaham, Eugene A Kiyatkin
Heroin use and overdose have increased in recent years as people transition from abusing prescription opiates to using the cheaper street drug. Despite a long history of research, many physiological effects of heroin and their underlying mechanisms remain unknown. Here, we used high-speed amperometry to examine the effects of intravenous heroin on oxygen and glucose levels in the nucleus accumbens (NAc) in freely-moving rats. Heroin within the dose range of human drug use and rat self-administration (100-200 μg/kg) induced a rapid, strong, but transient drop in NAc oxygen that was followed by a slower and more prolonged rise in glucose...
May 2017: ENeuro
https://www.readbyqxmd.com/read/28590302/a-subregion-of-the-parabrachial-nucleus-partially-mediates-respiratory-rate-depression-from-intravenous-remifentanil-in-young-and-adult-rabbits
#20
Justin R Miller, Edward J Zuperku, Eckehard A E Stuth, Anjishnu Banerjee, Francis A Hopp, Astrid G Stucke
BACKGROUND: The efficacy of opioid administration to reduce postoperative pain is limited by respiratory depression. We investigated whether clinically relevant opioid concentrations altered the respiratory pattern in the parabrachial nucleus, a pontine region contributing to respiratory pattern generation, and compared these effects with a medullary respiratory site, the pre-Bötzinger complex. METHODS: Studies were performed in 40 young and 55 adult artificially ventilated, decerebrate rabbits...
June 6, 2017: Anesthesiology
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