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Glycosylated ferritin

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https://www.readbyqxmd.com/read/28781105/adult-s-onset-still-disease-occurring-during-pregnancy-case-report-and-literature-review
#1
Léo Plaçais, Arsène Mekinian, Marie Bornes, Armelle Poujol-Robert, Naiké Bigé, Eric Maury, Olivier Fain
INTRODUCTION: Adult onset Still's disease is a rare affection classified among non-hereditary autoinflammatory diseases. We here report a case of AOSD revealed during pregnancy with a life-threatening presentation along with a review of 19 cases from literature. CASE: A 38-years old woman was treated in our department for diffuse systemic sclerosis and associated Sjögren syndrome. She was pregnant and presented with acute fever and arthralgias. Laboratory data revealed mild liver cytolysis but a large screening for infectious and auto-immune diseases was negative and hepato-biliar imaging was normal...
July 10, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28760536/validation-of-the-fautrel-classification-criteria-for-adult-onset-still-s-disease
#2
Delphine Lebrun, Stéphanie Mestrallet, Monique Dehoux, Jean Louis Golmard, Benjamin Granger, Sophie Georgin-Lavialle, Laurent Arnaud, Gilles Grateau, Jacques Pouchot, Bruno Fautrel
OBJECTIVES: To validate the Fautrel classification criteria for adult-onset Still's disease (AOSD) and to compare the discriminative performance to that of the Yamaguchi criteria. METHODS: We retrospectively reviewed the medical charts of 426 patients who had serum ferritin level and percentage glycosylated ferritin assayed at the biochemistry laboratory of Bichat Hospital. Medical data were extracted by use of a standardized form. All clinical, biological, and imaging features were collected, as well, evidence favoring an alternative diagnosis, specifically symptoms suggestive of other immune-mediated inflammatory diseases (IMID) or active infections...
July 12, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28745605/sex-and-age-affect-agreement-between-fasting-plasma-glucose-and-glycosylated-hemoglobin-for-diagnosis-of-dysglycemia
#3
Mercedes Lorenzo-Medina, Begoña Uranga, Antonio Rus, Rosa Martínez, Carolina Puertas, María Dolores Blanco, Ernesto Casís, Rosa Corcoy
AIM: To assess agreement between fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) levels for diagnosis of dysglycemia (diabetes and risk of diabetes), overall and depending on clinical characteristics. METHODS: The study enrolled 1020 adult subjects without drug-treated diabetes who underwent a laboratory test at a Spanish health care center. The criteria for dysglycemia of the American Diabetes Association were used. A logistic regression analysis was used to predict de novo diagnosis of dysglycemia based on sex, age, body mass index, anemia, and iron levels...
August 2017: Endocrinología, diabetes y nutrición
https://www.readbyqxmd.com/read/28722256/diagnostic-and-prognostic-value-of-low-percentage-of-glycosylated-ferritin-in-acquired-hemophagocytic-lymphohistiocytosis-a-single-center-study
#4
M Nabergoj, M Marinova, G Binotto, L Brugnaro, M Zaninotto, M Plebani, G Semenzato, F Vianello
INTRODUCTION: Hemophagocytic lymphohistiocytosis (HLH) is an aggressive and life-threatening syndrome characterized by an excessive immune activation. Glycosylated ferritin (GF) level has been proposed as highly specific of HLH. METHODS: We have studied 12 subjects with HLH according to the HLH-04 trial criteria and 11 patients with a clinical and laboratoristic suspicion of HLH. The percentage of GF was measured by an in-house assay. RESULTS: The only biomarkers that were significantly different in the two groups were fraction of GF (P<...
July 18, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28693994/ferritin-glycosylated-by-chitosan-as-a-novel-egcg-nano-carrier-structure-stability-and-absorption-analysis
#5
Rui Yang, Yuqian Liu, Yunjing Gao, Yongjin Wang, Chris Blanchard, Zhongkai Zhou
Ferritin is a shell-like carrier protein with an 8nm diameter cavity which endows a natural space to encapsulate food and drug components. In this work, phytoferritin was unprecedentedly glycosylated by chitosan to fabricate ferritin-chitosan Maillard reaction products (FCMPs) (grafting degree of 26.17%, 24h, 55°C). Results indicated that the amide I and II bands of ferritin were altered due to the chitosan grafting, whereas the ferritin spherical structure were retained. Simulated digestion analysis showed that the FCMPs were more resistant to pepsin and trypsin digestion as compared with ferritin alone...
December 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28229385/early-pregnancy-biochemical-predictors-of-gestational-diabetes-mellitus
#6
REVIEW
Camille E Powe
PURPOSE OF REVIEW: Universal oral glucose tolerance-based screening is employed to identify pregnant women with gestational diabetes mellitus (GDM), as treatment of this condition decreases the risk of associated complications. A simple and accurate blood test which identifies women at low or high risk for GDM in the first trimester would have the potential to decrease costs and improve outcomes through prevention or treatment. This review summarizes published data on early pregnancy biomarkers which have been tested as predictors of GDM...
February 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28174761/detection-of-glycosylation-and-iron-binding-protein-modifications-using-raman-spectroscopy
#7
Lorna Ashton, Victoria L Brewster, Elon Correa, Royston Goodacre
In this study we demonstrate the use of Raman spectroscopy to determine protein modifications as a result of glycosylation and iron binding. Most proteins undergo some modifications after translation which can directly affect protein function. Identifying these modifications is particularly important in the production of biotherapeutic agents as they can affect stability, immunogenicity and pharmacokinetics. However, post-translational modifications can often be difficult to detect with regard to the subtle structural changes they induce in proteins...
February 27, 2017: Analyst
https://www.readbyqxmd.com/read/28056319/-risk-factors-for-lower-extremity-amputation-in-patients-with-diabetic-foot
#8
B Xu, C Z Yang, S B Wu, D Zhang, L N Wang, L Xiao, Y Chen, C R Wang, A Tong, X F Zhou, X H Li, X H Guan
Objective: To explore the risk factors for lower extremity amputation in patients with diabetic foot. Methods: The clinical data of 1 771 patients with diabetic foot at the Air Force General Hospital of PLA from November 2001 to April 2015 were retrospectively analyzed. The patients were divided into the non-amputation and amputation groups. Within the amputation group, subjects were further divided into the minor and major amputation subgroups. Binary logistic regression analyses were used to assess the association between risk factors and lower extremity amputation...
January 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/28052375/unexplained-isolated-hyperferritinemia-without-iron-overload
#9
Giulia Ravasi, Sara Pelucchi, Raffaella Mariani, Marco Casati, Federico Greni, Cristina Arosio, Irene Pelloni, Silvia Majore, Paolo Santambrogio, Sonia Levi, Alberto Piperno
Although hyperferritinemia may be reflective of elevated total body iron stores, there are conditions in which ferritin levels are disproportionately elevated relative to iron status. Autosomal dominant forms of hyperferritinemia due to mutations in the L-ferritin IRE or in A helix of L-ferritin gene have been described, however cases of isolated hyperferritinemia still remain unsolved. We describe 12 Italian subjects with unexplained isolated hyperferritinemia (UIH). Four probands have affected siblings, but no affected parents or offspring...
April 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/27843366/adult-onset-still-s-disease-current-challenges-and-future-prospects
#10
REVIEW
Mariam Siddiqui, Michael S Putman, Anisha B Dua
Adult-onset Still's disease (AOSD) - a multi-systemic inflammatory condition characterized by high fevers, polyarthritis, an evanescent rash, and pharyngitis - has been a challenging condition to diagnose expediently and treat effectively. Questions remain regarding the underlying pathophysiology and etiology of AOSD. Pathognomonic diagnostic tests and reliable biomarkers remain undiscovered. Over the past decade, important progress has been made. Diagnostic criteria employing glycosylated ferritin have improved specificity...
2016: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/27783390/age-and-sex-distributions-of-age-related-biomarker-values-in-healthy-older-adults-from-the-long-life-family-study
#11
Paola Sebastiani, Bharat Thyagarajan, Fangui Sun, Lawrence S Honig, Nicole Schupf, Stephanie Cosentino, Mary F Feitosa, Mary Wojczynski, Anne B Newman, Monty Montano, Thomas T Perls
OBJECTIVES: To determine reference values for laboratory tests in individuals aged 85 and older. DESIGN: Cross-sectional cohort study. SETTING: International. PARTICIPANTS: Long Life Family Study (LLFS) participants (N~5,000, age: range 25-110, median 67, 45% male). MEASUREMENTS: Serum biomarkers were selected based on association with aging-related diseases and included complete blood count, lipids (triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, total cholesterol), 25-hydroxyvitamin D2 and D3, vitamin D epi-isomer, diabetes mellitus-related biomarkers (adiponectin, insulin, insulin-like growth factor 1, glucose, glycosylated hemoglobin, soluble receptor for advanced glycation endproduct), kidney disease-related biomarkers (albumin, creatinine, cystatin), endocrine biomarkers (dehydroepiandrosterone, sex-hormone binding globulin, testosterone), markers of inflammation (interleukin 6, high-sensitivity C-reactive protein, N-terminal pro b-type natriuretic peptide), ferritin, and transferrin...
November 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27706659/molecular-cloning-overexpression-purification-and-sequence-analysis-of-the-giant-panda-ailuropoda-melanoleuca-ferritin-light-polypeptide
#12
L Fu, Y L Hou, X Ding, Y J Du, H Q Zhu, N Zhang, W R Hou
The complementary DNA (cDNA) of the giant panda (Ailuropoda melanoleuca) ferritin light polypeptide (FTL) gene was successfully cloned using reverse transcription-polymerase chain reaction technology. We constructed a recombinant expression vector containing FTL cDNA and overexpressed it in Escherichia coli using pET28a plasmids. The expressed protein was then purified by nickel chelate affinity chromatography. The cloned cDNA fragment was 580 bp long and contained an open reading frame of 525 bp. The deduced protein sequence was composed of 175 amino acids and had an estimated molecular weight of 19...
August 30, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27605239/soluble-transferrin-receptor-levels-are-positively-associated-with-insulin-resistance-but-not-with-the-metabolic-syndrome-or-its-individual-components
#13
Milton Fabian Suárez-Ortegón, Stela McLachlan, Sarah H Wild, José Manuel Fernández-Real, Caroline Hayward, Ozren Polašek
The metabolic syndrome (MetS) is known to be associated with elevated serum ferritin levels. The possible association with other Fe markers has been less well studied. We aimed to investigate the cross-sectional association of soluble transferrin receptor (sTfR) and ferritin levels with the MetS components, insulin resistance and glycosylated Hb (HbA1C). The sample consisted of 725 adults, aged 19-93 years (284 men, 151 premenopausal and 290 postmenopausal women), from the Croatian island of Vis. Serum sTfR and ferritin levels were measured by immunoturbidimetry and electrochemiluminescence assays, respectively...
October 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/26082668/tyrosine-levels-are-associated-with-insulin-resistance-in-patients-with-nonalcoholic-fatty-liver-disease
#14
Miwa Kawanaka, Ken Nishino, Takahito Oka, Noriyo Urata, Jun Nakamura, Mitsuhiko Suehiro, Hirofumi Kawamoto, Yasutaka Chiba, Gotaro Yamada
OBJECTIVE: Amino acid imbalance is often found in patients with cirrhosis, and this imbalance is associated with insulin resistance. However, the mechanism underlying the relationship between amino acid imbalance and insulin resistance remains unclear. We evaluated serum amino acid concentrations in patients with nonalcoholic fatty liver disease to determine if any of the levels of amino acids were associated with the biochemical markers and fibrosis stage of nonalcoholic steatohepatitis (NASH)...
2015: Hepatic Medicine: Evidence and Research
https://www.readbyqxmd.com/read/25098416/co-occurrence-of-kikuchi-fujimoto-s-disease-and-still-s-disease-case-report-and-review-of-previously-reported-cases
#15
REVIEW
Karen A Toribio, Hideko Kamino, Stephanie Hu, Miriam Pomeranz, Michael H Pillinger
Kikuchi-Fujimoto's disease (KFD) and adult-onset Still's disease (AOSD) are rare inflammatory conditions with some overlapping features. We encountered a 22-year-old male patient who presented with daily fevers, neck discomfort, and sore throat and subsequently developed rash, arthritis, and cervical lymphadenopathy. Biopsy of the skin rash was consistent with KFD skin involvement. Given that the patient also met criteria for AOSD, a final diagnosis of KFD/AOSD co-occurrence was made. Anti-IL-1β therapy with anakinra resulted in rapid resolution of all symptoms...
December 2015: Clinical Rheumatology
https://www.readbyqxmd.com/read/24908763/-blood-specimen-collection-in-general-practice-must-patients-actually-be-fasting
#16
H S Füessl, P Stiefelhagen
No abstract text is available yet for this article.
March 6, 2014: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/24901538/proteomic-changes-in-serum-of-first-onset-antidepressant-drug-na%C3%A3-ve-major-depression-patients
#17
RANDOMIZED CONTROLLED TRIAL
Viktoria Stelzhammer, Frieder Haenisch, Man K Chan, Jason D Cooper, Johann Steiner, Hannah Steeb, Daniel Martins-de-Souza, Hassan Rahmoune, Paul C Guest, Sabine Bahn
Major depressive disorder (MDD) is a complex and multi-factorial disorder. Although genetic factors and other molecular aspects of MDD have been widely studied, the underlying pathological mechanisms are still mostly unknown. We sought to investigate the pathophysiology of MDD by identifying and characterising serum molecular differences and their correlation to symptom severity in first onset, antidepressant drug-naïve MDD patients. We performed an exploratory molecular profiling study on serum samples of MDD patients and controls using multiplex immunoassay and label-free liquid chromatography mass spectrometry in data independent mode (LC-MSE)...
October 2014: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/24657513/adult-onset-still-s-disease
#18
REVIEW
Mathieu Gerfaud-Valentin, Yvan Jamilloux, Jean Iwaz, Pascal Sève
First described in 1971, adult-onset Still's disease (AOSD) is a rare multisystemic disorder considered as a complex (multigenic) autoinflammatory syndrome. A genetic background would confer susceptibility to the development of autoinflammatory reactions to environmental triggers. Macrophage and neutrophil activation is a hallmark of AOSD which can lead to a reactive hemophagocytic lymphohistiocytosis. As in the latter disease, the cytotoxic function of natural killer cells is decreased in patients with active AOSD...
July 2014: Autoimmunity Reviews
https://www.readbyqxmd.com/read/24646465/adult-onset-still-disease-manifestations-treatment-outcome-and-prognostic-factors-in-57-patients
#19
Mathieu Gerfaud-Valentin, Delphine Maucort-Boulch, Arnaud Hot, Jean Iwaz, Jacques Ninet, Isabelle Durieu, Christiane Broussolle, Pascal Sève
We conducted a retrospective observational study to describe a cohort and identify the prognostic factors in adult-onset Still disease (AOSD). Patients enrolled in this retrospective chart review fulfilled either Yamaguchi or Fautrel criteria. Candidate variables were analyzed with logistic unadjusted and adjusted regression models. Fifty-seven patients were seen in the internal medicine (75%) and rheumatology (25%) departments over a mean period of 8.4 years. The median time to diagnosis was 4 months. The course of AOSD was monocyclic in 17 patients, polycyclic in 25, and chronic in 15...
March 2014: Medicine (Baltimore)
https://www.readbyqxmd.com/read/24309545/-myopericarditis-as-the-presenting-manifestation-of-adult-still-s-disease
#20
E Oehler, F Valour, E Hachulla, F Ghawche
INTRODUCTION: Adult Still's disease may present with multiple non-specific clinical manifestations leading to diagnostic difficulties. Presentation as initial myopericarditis is rare but must be known. CASE REPORT: We report a 49-year-old man who presented with the sudden onset of a high fever, arthralgia and myalgia, skin rash, dyspnea and chest pain related to a myopericarditis. Infectious, neoplastic and autoimmune diagnostic work-up was non-contributive. Adult Still's disease was discussed and confirmed by the decrease in the glycosylated fraction of ferritin...
December 2014: La Revue de Médecine Interne
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