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Glycosylated ferritin

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https://www.readbyqxmd.com/read/27843366/adult-onset-still-s-disease-current-challenges-and-future-prospects
#1
REVIEW
Mariam Siddiqui, Michael S Putman, Anisha B Dua
Adult-onset Still's disease (AOSD) - a multi-systemic inflammatory condition characterized by high fevers, polyarthritis, an evanescent rash, and pharyngitis - has been a challenging condition to diagnose expediently and treat effectively. Questions remain regarding the underlying pathophysiology and etiology of AOSD. Pathognomonic diagnostic tests and reliable biomarkers remain undiscovered. Over the past decade, important progress has been made. Diagnostic criteria employing glycosylated ferritin have improved specificity...
2016: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/27783390/age-and-sex-distributions-of-age-related-biomarker-values-in-healthy-older-adults-from-the-long-life-family-study
#2
Paola Sebastiani, Bharat Thyagarajan, Fangui Sun, Lawrence S Honig, Nicole Schupf, Stephanie Cosentino, Mary F Feitosa, Mary Wojczynski, Anne B Newman, Monty Montano, Thomas T Perls
OBJECTIVES: To determine reference values for laboratory tests in individuals aged 85 and older. DESIGN: Cross-sectional cohort study. SETTING: International. PARTICIPANTS: Long Life Family Study (LLFS) participants (N~5,000, age: range 25-110, median 67, 45% male). MEASUREMENTS: Serum biomarkers were selected based on association with aging-related diseases and included complete blood count, lipids (triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, total cholesterol), 25-hydroxyvitamin D2 and D3, vitamin D epi-isomer, diabetes mellitus-related biomarkers (adiponectin, insulin, insulin-like growth factor 1, glucose, glycosylated hemoglobin, soluble receptor for advanced glycation endproduct), kidney disease-related biomarkers (albumin, creatinine, cystatin), endocrine biomarkers (dehydroepiandrosterone, sex-hormone binding globulin, testosterone), markers of inflammation (interleukin 6, high-sensitivity C-reactive protein, N-terminal pro b-type natriuretic peptide), ferritin, and transferrin...
November 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27706659/molecular-cloning-overexpression-purification-and-sequence-analysis-of-the-giant-panda-ailuropoda-melanoleuca-ferritin-light-polypeptide
#3
L Fu, Y L Hou, X Ding, Y J Du, H Q Zhu, N Zhang, W R Hou
The complementary DNA (cDNA) of the giant panda (Ailuropoda melanoleuca) ferritin light polypeptide (FTL) gene was successfully cloned using reverse transcription-polymerase chain reaction technology. We constructed a recombinant expression vector containing FTL cDNA and overexpressed it in Escherichia coli using pET28a plasmids. The expressed protein was then purified by nickel chelate affinity chromatography. The cloned cDNA fragment was 580 bp long and contained an open reading frame of 525 bp. The deduced protein sequence was composed of 175 amino acids and had an estimated molecular weight of 19...
August 30, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27605239/soluble-transferrin-receptor-levels-are-positively-associated-with-insulin-resistance-but-not-with-the-metabolic-syndrome-or-its-individual-components
#4
Milton Fabian Suárez-Ortegón, Stela McLachlan, Sarah H Wild, José Manuel Fernández-Real, Caroline Hayward, Ozren Polašek
The metabolic syndrome (MetS) is known to be associated with elevated serum ferritin levels. The possible association with other Fe markers has been less well studied. We aimed to investigate the cross-sectional association of soluble transferrin receptor (sTfR) and ferritin levels with the MetS components, insulin resistance and glycosylated Hb (HbA1C). The sample consisted of 725 adults, aged 19-93 years (284 men, 151 premenopausal and 290 postmenopausal women), from the Croatian island of Vis. Serum sTfR and ferritin levels were measured by immunoturbidimetry and electrochemiluminescence assays, respectively...
October 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/26082668/tyrosine-levels-are-associated-with-insulin-resistance-in-patients-with-nonalcoholic-fatty-liver-disease
#5
Miwa Kawanaka, Ken Nishino, Takahito Oka, Noriyo Urata, Jun Nakamura, Mitsuhiko Suehiro, Hirofumi Kawamoto, Yasutaka Chiba, Gotaro Yamada
OBJECTIVE: Amino acid imbalance is often found in patients with cirrhosis, and this imbalance is associated with insulin resistance. However, the mechanism underlying the relationship between amino acid imbalance and insulin resistance remains unclear. We evaluated serum amino acid concentrations in patients with nonalcoholic fatty liver disease to determine if any of the levels of amino acids were associated with the biochemical markers and fibrosis stage of nonalcoholic steatohepatitis (NASH)...
2015: Hepatic Medicine: Evidence and Research
https://www.readbyqxmd.com/read/25098416/co-occurrence-of-kikuchi-fujimoto-s-disease-and-still-s-disease-case-report-and-review-of-previously-reported-cases
#6
REVIEW
Karen A Toribio, Hideko Kamino, Stephanie Hu, Miriam Pomeranz, Michael H Pillinger
Kikuchi-Fujimoto's disease (KFD) and adult-onset Still's disease (AOSD) are rare inflammatory conditions with some overlapping features. We encountered a 22-year-old male patient who presented with daily fevers, neck discomfort, and sore throat and subsequently developed rash, arthritis, and cervical lymphadenopathy. Biopsy of the skin rash was consistent with KFD skin involvement. Given that the patient also met criteria for AOSD, a final diagnosis of KFD/AOSD co-occurrence was made. Anti-IL-1β therapy with anakinra resulted in rapid resolution of all symptoms...
December 2015: Clinical Rheumatology
https://www.readbyqxmd.com/read/24908763/-blood-specimen-collection-in-general-practice-must-patients-actually-be-fasting
#7
H S Füessl, P Stiefelhagen
No abstract text is available yet for this article.
March 6, 2014: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/24901538/proteomic-changes-in-serum-of-first-onset-antidepressant-drug-na%C3%A3-ve-major-depression-patients
#8
RANDOMIZED CONTROLLED TRIAL
Viktoria Stelzhammer, Frieder Haenisch, Man K Chan, Jason D Cooper, Johann Steiner, Hannah Steeb, Daniel Martins-de-Souza, Hassan Rahmoune, Paul C Guest, Sabine Bahn
Major depressive disorder (MDD) is a complex and multi-factorial disorder. Although genetic factors and other molecular aspects of MDD have been widely studied, the underlying pathological mechanisms are still mostly unknown. We sought to investigate the pathophysiology of MDD by identifying and characterising serum molecular differences and their correlation to symptom severity in first onset, antidepressant drug-naïve MDD patients. We performed an exploratory molecular profiling study on serum samples of MDD patients and controls using multiplex immunoassay and label-free liquid chromatography mass spectrometry in data independent mode (LC-MSE)...
October 2014: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/24657513/adult-onset-still-s-disease
#9
REVIEW
Mathieu Gerfaud-Valentin, Yvan Jamilloux, Jean Iwaz, Pascal Sève
First described in 1971, adult-onset Still's disease (AOSD) is a rare multisystemic disorder considered as a complex (multigenic) autoinflammatory syndrome. A genetic background would confer susceptibility to the development of autoinflammatory reactions to environmental triggers. Macrophage and neutrophil activation is a hallmark of AOSD which can lead to a reactive hemophagocytic lymphohistiocytosis. As in the latter disease, the cytotoxic function of natural killer cells is decreased in patients with active AOSD...
July 2014: Autoimmunity Reviews
https://www.readbyqxmd.com/read/24646465/adult-onset-still-disease-manifestations-treatment-outcome-and-prognostic-factors-in-57-patients
#10
Mathieu Gerfaud-Valentin, Delphine Maucort-Boulch, Arnaud Hot, Jean Iwaz, Jacques Ninet, Isabelle Durieu, Christiane Broussolle, Pascal Sève
We conducted a retrospective observational study to describe a cohort and identify the prognostic factors in adult-onset Still disease (AOSD). Patients enrolled in this retrospective chart review fulfilled either Yamaguchi or Fautrel criteria. Candidate variables were analyzed with logistic unadjusted and adjusted regression models. Fifty-seven patients were seen in the internal medicine (75%) and rheumatology (25%) departments over a mean period of 8.4 years. The median time to diagnosis was 4 months. The course of AOSD was monocyclic in 17 patients, polycyclic in 25, and chronic in 15...
March 2014: Medicine (Baltimore)
https://www.readbyqxmd.com/read/24309545/-myopericarditis-as-the-presenting-manifestation-of-adult-still-s-disease
#11
E Oehler, F Valour, E Hachulla, F Ghawche
INTRODUCTION: Adult Still's disease may present with multiple non-specific clinical manifestations leading to diagnostic difficulties. Presentation as initial myopericarditis is rare but must be known. CASE REPORT: We report a 49-year-old man who presented with the sudden onset of a high fever, arthralgia and myalgia, skin rash, dyspnea and chest pain related to a myopericarditis. Infectious, neoplastic and autoimmune diagnostic work-up was non-contributive. Adult Still's disease was discussed and confirmed by the decrease in the glycosylated fraction of ferritin...
December 2014: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/24284436/associations-between-red-meat-intake-and-biomarkers-of-inflammation-and-glucose-metabolism-in-women
#12
Sylvia H Ley, Qi Sun, Walter C Willett, A Heather Eliassen, Kana Wu, An Pan, Fran Grodstein, Frank B Hu
BACKGROUND: Greater red meat intake is associated with an increased type 2 diabetes and cardiovascular disease risk. However, the relation of red meat intake to biomarkers of inflammation and glucose metabolism has not been investigated thoroughly. OBJECTIVE: We hypothesized that greater red meat intake would be associated with biomarkers of inflammation and glucose metabolism, which would be partly explained by body mass index (BMI). DESIGN: We analyzed cross-sectional data from diabetes-free female participants in the Nurses' Health Study (n = 3690)...
February 2014: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/23956199/characterization-and-recombinant-protein-expression-of-ferritin-light-chain-homologue-in-the-silkworm-bombyx-mori
#13
Sun Mee Hong, Hiroaki Mon, Jae Man Lee, Takahiro Kusakabe
The silkworm genome encodes three iron storage proteins or ferritins, Fer1HCH, Fer2LCH, and Fer3HCH. Probing our EST library constructed from 1-day-old silkworm eggs revealed only Fer2LCH mRNA, which encoded for a protein with a predicted putative N-glycosylation site. Developmental and tissue expression analyses during embryogenesis revealed that Fer2LCH mRNA was abundant from 6 h to 6 days after oviposition. Transcriptional expression of Fer2LCH during the postembryonic stage is also high in the larval fat body and mid-gut, and then is upregulated in all pupal tissues tested...
April 2014: Insect Science
https://www.readbyqxmd.com/read/23891275/comparative-effects-of-pioglitazone-and-metformin-on-oxidative-stress-markers-in-newly-diagnosed-type-2-diabetes-patients-a-randomized-clinical-trial
#14
RANDOMIZED CONTROLLED TRIAL
Hossein Mirmiranpour, Mostafa Mousavizadeh, Sina Noshad, Mojgan Ghavami, Maryam Ebadi, Mehrnaz Ghasemiesfe, Manouchehr Nakhjavani, Alireza Esteghamati
AIMS: Recent studies have suggested that pioglitazone exerts anti-oxidant properties which may countervail oxidative stress (OS). We aimed to elucidate the effects of pioglitazone on OS modulation and to compare its effects with metformin. METHODS: Data from the randomized clinical trial (registration no.NCT01521624) were used. Newly diagnosed type 2 diabetes patients were assigned to pioglitazone 30mg daily (n=30), metformin 1000mg daily (n=50), or no medication (n=49)...
September 2013: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/23858089/red-meat-dietary-heme-iron-and-risk-of-type-2-diabetes-the-involvement-of-advanced-lipoxidation-endproducts
#15
REVIEW
Desley L White, Avril Collinson
There is growing evidence of disordered iron homeostasis in the diabetic condition, with links proposed between dietary iron intakes and both the risk of disease and the risk of complications of advanced disease. In the United States, Britain, and Canada, the largest dietary contributors of iron are cereals and cereal products and meat and meat products. This review discusses the findings of cohort studies and meta-analyses of heme iron and red meat intakes and the risk of type 2 diabetes. These suggest that processed red meat is associated with increased risk, with high intakes of red meat possibly also associated with a small increased risk...
July 2013: Advances in Nutrition
https://www.readbyqxmd.com/read/23837272/insulin-resistance-in-patients-with-type-1-diabetes-relationship-with-metabolic-and-inflammatory-parameters
#16
Tomislav Bulum, Lea Duvnjak
Although insulin resistance is usually associated with the development of type 2 diabetes, it can also be a feature of patients with type 1 diabetes. Insulin resistance has been documented in type 1 diabetes and may contribute to the high risk of cardiovascular disease in this population. To investigate the relationship of insulin resistance with metabolic and inflammatory parameters we divided 304 patients according to median estimated glucose disposal rate (eGDR = 9.72 mgkg(-1)min(-1)) into lower (n = 153) and higher (n = 151) insulin sensitivity groups...
March 2013: Acta Clinica Croatica
https://www.readbyqxmd.com/read/23632762/characterization-of-chronic-subdural-hematoma-fluid-proteome
#17
Anna-Leena Heula, Steffen Ohlmeier, Juha Sajanti, Kari Majamaa
BACKGROUND: Chronic subdural hematoma (CSDH) is commonly caused by head injury, but the progression of CSDH is recognized as an inflammatory process. The protein composition of the CSDH fluid has not been fully elucidated, nor has the contribution of its components to the enlargement of the hematoma cavity and to its chronic manifestation. OBJECTIVE: To characterize the protein content of CSDH fluid and study the differences between CSDH fluid and serum to identify proteins putatively involved in the pathogenesis of CSDH...
August 2013: Neurosurgery
https://www.readbyqxmd.com/read/23531247/-investigation-of-iron-deficiency-status-in-the-newborns-of-gestational-diabetes-mellitus-women
#18
Yi Ye, Meng Wang, Ke Chen, Ai-lan Xie
OBJECTIVE: To investigate the iron status in the newborns of maternal gestational diabetes mellitus (GDM) women, and explore the mechanism of iron deficiency in these newborns. METHODS: From June 2008 to October 2011, 64 GDM women (GDM group) and 71 healthy pregnant women (control group) who delivered in the Second Affiliated Hospital of Wenzhou Medical College and their newborns were studied prospectively. Serum ferritin (SF), serum transferrin receptor (sTfR), erythropoietin (Epo), haemoglobin (Hb), serum level of insulin and plasma glucose in cord blood was measured...
January 2013: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/23377481/relation-of-iron-stores-to-oxidative-stress-in-type-2-diabetes
#19
COMPARATIVE STUDY
D Kundu, A Roy, T Mandal, U Bandyopadhyay, E Ghosh, D Ray
BACKGROUND: Recent studies revealed elevated serum ferritin levels predict new-onset type 2 diabetes. Further studies proved ferritin to be an important and independent predictor of the development of diabetes. The link between hyperglycemia, enhanced free radical activity (oxidative stress) and serum iron and its stores (serum ferritin levels) levels is not clear. OBJECTIVES: The present study is an attempt to understand the relationship between serum ferritin levels and oxidative stress (measured by malondialdehyde)...
January 2013: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/23312547/high-ferritin-and-low-transferrin-saturation-are-associated-with-pre-diabetes-among-a-national-representative-sample-of-u-s-adults
#20
Ching-Lung Cheung, Tommy T Cheung, Karen S L Lam, Bernard M Y Cheung
BACKGROUND & AIMS: Iron overload is known to cause diabetes. However, the underlying mechanism is poorly understood. We therefore studied the association of different markers of iron metabolism, namely ferritin, erythrocyte protoporphyrin and transferrin saturation (TSAT, as defined by a percentage of transferrin that is saturated with iron) with pre-diabetes (preDM) in US adults without chronic kidney disease, anemia, and iron deficiency. METHODS: Data on 2575 participants of the National Health and Nutrition Examination Survey (NHANES) 1999-2002 who were free of diabetes, chronic kidney disease, iron deficiency, and anemia were analyzed...
December 2013: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
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