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Elderly and Diseases

Suha Al-Butmeh, Njah Al-Khataib
BACKGROUND: The focus of this study was quality of life and mental health in elderly people living in the Bethlehem district. The aim of this study was to identify the most prevalent mental health problems and how they affect quality of life. METHODS: This cross-sectional study was done in June and July, 2010. We recruited a convenience sample of elderly people (aged 65 years and older) living in the Bethlehem district of occupied Palestinian territory. Using a structured questionnaire, we assessed quality of life with the WHOQOL-BREF and current psychological status and distress with the Brief Symptom Inventor...
February 21, 2018: Lancet
Fen Li, Bifan Zhu, Zhimin He, Xiaoxi Zhang, Changying Wang, Linan Wang, Peipei Song, Lingling Ding, Chunlin Jin
The aim of this study was to use data from the Information Center of the Shanghai Municipal Commission of Health and Family Planning (SMCHFP) to determine the factors affecting end-of-life hospital costs of patients. A total number of 43,806 decedents who died in medical facilities in 2015 were examined. These individuals, accounted for 34.85% of all deaths in 2015 in Shanghai. Descriptive analysis and multiple linear regression analysis were performed using STATA 13.0. Results indicated that 88.94% of the decedents who died in medical facilities were over age 60...
2018: Bioscience Trends
Xiang-Wu Yang, Shai-Hong Zhu, Peng-Zhou Li, Wei-Zheng Li, Xu-Long Sun
PURPOSE: This study aimed to compare the short- and longterm outcomes of elderly and middle-aged patients with gastric cancer who underwent laparoscopic gastrectomy. METHODS: From January 2010 to February 2017, a total of 75 patients with gastric cancer aged ≥70 years (elderly group) underwent laparoscopic gastrectomy, and their short- and long-term outcomes were compared with those of 197 patients with gastric cancer aged 60-69 years (middleaged group) who underwent also laparoscopic gastrectomy during the same period...
January 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Yunlei Wang, Jianwei Zheng, Zhigang Gao, Xiaofeng Han, Fanrong Qiu
PURPOSE: To investigate the malnutrition, the incidence of nutritional risk and the application of nutritional support for patients with colorectal cancer, so as to provide a basis for the rational clinical application of nutritional support. METHODS: A total of 264 surgical patients with colorectal cancer treated/followed up from January 2016 to March 2017 in Beijing Chaoyang Hospital were selected. The nutritional risk was assessed using the Nutritional Risk Screening 2002 (NRS2002), and the nutritional risk and application of nutritional support for patients with different gender, age and clinical disease stage were analyzed; the hospitalization duration and postoperative complications were also analyzed and compared...
January 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Guangyuan Sun, Jun Xue, Yue Zhang, Xiaobin Gao, Fei Guo
PURPOSE: This study aimed to use propensity score matching (PSM) to compare the short- and long-term outcomes of laparoscopic surgery for the treatment of rectal cancer in elderly and middle-aged patients. METHODS: Data were retrospectively obtained from 588 patients aged ≥60 years when they underwent laparoscopic surgery for rectal cancer in our hospital between January 2009 and December 2016. The patients were divided into an elderly group (≥70 years) or a middle-aged group (60-69 years), and were subsequently matched 1:1 using PSM for sex, body mass index, Charlson comorbidity index (CCI), tumor location, clinical stage, and American Society of Anesthesiologists (ASA) score...
January 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Dongliang Bian, Feng Zhou, Weiguang Yang, Kaixuan Zhang, Linsong Chen, Gening Jiang, Peng Zhang, Chunyan Wu, Ke Fei, Lei Zhang
Background: Thymoma, though a rare tumor disease, is the most common tumor of the anterior mediastinum. However, tumor size, as a critical factor, has been underestimated. Results: Age, advanced tumor stage, and preoperative radiotherapy were poor prognostic factors of overall survival (OS) and disease specific survival (DSS) ( P < 0.05 for all). Besides, tumor size was significantly related to survival. The larger tumor size indicated the less OS and DSS ( P < 0...
February 23, 2018: Oncotarget
Li Peng, Zhiping Xu, Zhenyu Huo, Rui Long, Liang Ma
Background: Despite increasing incidence of pulmonary fungal infections (PFIs) worldwide, the clinical characteristics and prognostic factors remain poorly understood. The goal of this study was to investigate the clinical features, laboratory findings, and outcomes of hospitalized patients diagnosed with PFIs. Methods: We retrospectively enrolled 123 patients at a university hospital in Southwestern China between February 2014 and May 2016, who were diagnosed with PFIs based on clinical presentations and laboratory tests including fungal culture and pathological examination...
2018: Infection and Drug Resistance
Jiadela Teliewubai, Bin Bai, Yiwu Zhou, Yuyan Lu, Shikai Yu, Chen Chi, Jue Li, Jacques Blacher, Yawei Xu, Yi Zhang
Objective: Secreted frizzled related protein 5 (SFRP5) is a novel anti-inflammatory adipokine that is implicated in metabolic and cardiovascular disease (CVD). However, little is known about the relevance of SFRP5 with asymptomatic hypertensive target organ damages (TODs). We aimed to investigate the association between SFRP5 and TOD in a large population. Clinical trial registration: NCT02368938. Methods: A total of 1,745 community-dwelling elderly subjects aged over 65 years from northern Shanghai were recruited in the study...
2018: Clinical Interventions in Aging
Osnat Bairey, Tali Siegal
Primary central nervous system lymphoma (PCNSL) is a rare and aggressive brain tumor. The prognosis is poor, with high rates of relapse and disease progression after treatment. In addition, PCNSL affects a largely older population, so that a significant proportion of patients are ineligible for intensive therapies and high-dose chemotherapy. The elderly patients are also susceptible to the accelerated and detrimental cognitive side effects of whole-brain irradiation which is an alternative consolidation to high-dose chemotherapy...
March 11, 2018: Blood Reviews
Livia Fernandes de Lima, Fernando Barbosa, Marcus Vinícius Simões, Anderson Marliere Navarro
INTRODUCTION: Heart failure (HF) is a growing public health issue; its risk factors include inappropriate dietary intake of microelements such as iodine, selenium, zinc and iron, which may lead to thyroid dysfunction. OBJECTIVE: This study aimed to assess the correlation among the functional class stages of patients with HF, iodine, selenium, iron and zinc levels with the presence of thyroid dysfunction. METHODOLOGY: One hundred nine patients from the HF outpatient clinic of the Clinics Hospital of Ribeirão Preto whose blood and urine were collected for micronutrient analysis and laboratory tests were selected...
March 3, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
C Foguem, M Lemdani, C Huart
BACKGROUND: Human nasal chemosensation is mediated by two separate, though interacting sensory pathways: the trigeminal and olfactory systems. Trigeminal sensitivity and olfacto-trigeminal interactions have not yet been well studied in idiopathic Parkinsons disease (IPD). OBJECTIVES: The aim of this study was to assess odour detection thresholds in elderly IPD patients, and compare them to the odour detection thresholds of healthy controls. Finally, we investigated potential interactions between trigeminal and olfactory sensitivity...
March 18, 2018: Rhinology
Sérgio Dos Anjos Garnes, Adriana Bottoni, Fernanda Lasakosvitsch, Andrea Bottoni
OBJECTIVE: This study developed an instrument in table format to help determine the energy requirements of patients in adverse situations. The instrument allows for the weekly adjustment of nutrition therapy and energy intake, advocating a new approach to treatment based on clinical observation performed by staff specialized in individualized nutrition therapy. METHODS: The table was elaborated by grouping patients according to the following criteria: criticality, chronicity, and stability of the clinical status...
February 3, 2018: Nutrition
Asli Kilavuz, Reci Meseri, Sumru Savas, Hatice Simsek, Sevnaz Sahin, Derya Hopanci Bicakli, Fulden Sarac, Mehmet Uyar, Fehmi Akcicek
OBJECTIVE: Sarcopenia, functional disability, and depression are common problems in the elderly. Sarcopenia is associated with physical disability, functional impairment, depression, cardiometabolic diseases, and even mortality. This study aims to determine the association of sarcopenia with depression and functional status among ambulatory community-dwelling elderly aged 65 years and older. MATERIALS AND METHOD: The sample of this cross-sectional study consisted of 28,323 people, aged 65 years and older, living in Bornova, Izmir...
March 15, 2018: Archives of Gerontology and Geriatrics
Fabrizio Pancaldi, Marco Sebastiani, Giulia Cassone, Fabrizio Luppi, Stefania Cerri, Giovanni Della Casa, Andreina Manfredi
The diagnosis of interstitial lung diseases in patients affected by rheumatoid arthritis is fundamental to improving their survival rate. In particular, the average survival time of patients affected by rheumatoid arthritis with pulmonary implications is approximately 3 years. The gold standard for confirming the diagnosis of this disease is computer tomography. However, it is very difficult to raise diagnosis suspicion because the symptoms of the disease are extremely common in elderly people. The detection of the so-called velcro crackle in lung sounds can effectively raise the suspicion of an interstitial disease and speed up diagnosis...
March 9, 2018: Computers in Biology and Medicine
Tobias Boch, Thomas Luft, Georgia Metzgeroth, Maximilian Mossner, Johann-Christoph Jann, Daniel Nowak, Franziska La Meir, Christiane Schumann, Jennifer Klemmer, Susanne Brendel, Harald Fricke, Claudia Kunz, Christel Weiß, Wolf-Karsten Hofmann, Florian Nolte
In low risk MDS, increased apoptosis of erythroid progenitors mediated via CD95 (Fas) activation has been described to result in peripheral cytopenia. Blockade of the CD95 system can improve erythropoiesis in MDS. Asunercept (APG101) is a fusion protein consisting of the extracellular domain of human CD95 and the Fc domain of human IgG1 blocking the interaction between CD95 and its ligand. Here we report on results from a phase I study in 20 transfusion-dependent low and intermediate risk MDS patients treated with intravenous asunercept (EudraCT 2012-003027-37)...
March 10, 2018: Leukemia Research
Xiao Luo, Kaicheng Li, Y L Jia, Qingze Zeng, Yeerfan Jiaerken, Tiantian Qiu, Peiyu Huang, Xiaojun Xu, Zhujing Shen, Xiaojun Guan, Jiong Zhou, Chao Wang, J J Xu, Minming Zhang
The APOE ε4 allele is associated with impaired intrinsic functional connectivity in neural networks, especially in the default mode network (DMN). However, effective connectivity (EC) reflects the direct causal effects of one brain region to another, which has rarely been investigated. Recently, Granger causality analysis (GCA) proved suitable for the study of directionality in neuronal interactions. Using GCA, we examined the differences in the EC between the anterior medial prefrontal cortex/posterior cingulate cortex (aMPFC/PCC) and the whole brain in 17 ε4 carrying and 32 non-carrying cognitively intact elderly individuals...
March 17, 2018: Brain Imaging and Behavior
Maria Lorenzi, Stefano Bonassi, Teresa Lorenzi, Silvia Giovannini, Roberto Bernabei, Graziano Onder
Sarcopenia and frailty are associated with several important health-related adverse events, including disability, loss of independence, institutionalization and mortality. Sarcopenia can be considered a biological substrate of frailty, and the prevalence of both these conditions progressively increases with age. Telomeres are nucleoprotein structures located at the end of linear chromosomes and implicated in cellular ageing, shorten with age, and are associated with various age-related diseases. In addition, telomere length (TL) is widely considered a molecular/cellular hallmark of the ageing process...
March 16, 2018: Biogerontology
Xiangjun Li, Mingsheng Chen, Zhonghua Wang, Lei Si
OBJECTIVE: In general, published studies analyse healthcare utilisation, rather than foregone care, among different population groups. The assessment of forgone care as an aspect of healthcare system performance is important because it indicates the gap between perceived need and actual utilisation of healthcare services. This study focused on a specific vulnerable group, middle-aged and elderly people with chronic diseases, and evaluated the prevalence of foregone care and associated factors among this population in China...
March 16, 2018: BMJ Open
Alina Yang, Ji Liu
The population of patients on left ventricular assist devices (LVADs) has increased significantly since the 1990s, and with it, need for non-cardiac elective surgeries. Presence of an LVAD or heart failure, however, can cause physicians to perceive these patients to be at prohibitively high risk for elective surgery. Nevertheless, as one of the most common causes of poor vision in the elderly, cataracts can significantly limit improvements in quality of life that a patient may have otherwise gained from LVAD support...
March 16, 2018: BMJ Case Reports
Valérie Haydont, Bruno A Bernard, Nicolas O Fortunel
Ageing is today a major societal concern that is intrinsically associated with the increase of life expectancy. Outside the context of severe degenerative diseases that affect the elderly populations, normal visible signs of ageing, notably skin sagging and wrinkles, influence the social and individual perception of peoples. Accordingly, there is a strong demand for researches on skin ageing. Deciphering the cellular and molecular processes of skin evolution through ageing is thus an active scientific domain, at the frontier of tissue developmental and ageing biology...
March 13, 2018: Mechanisms of Ageing and Development
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