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https://www.readbyqxmd.com/read/27933354/-pathophysiology-diagnosis-and-treatment-of-zenker-s-diverticulum
#1
T Hussain, J T Maurer, S Lang, B A Stuck
Zenker's diverticulum occurs at the dorsal pharyngoesophageal junction through Killian's dehiscence and is caused by increased intrabolus pressure. Symptomatic disease most frequently affects male elderly patients. Primary symptom is oropharyngeal dysphagia, as well as regurgitation of undigested food, halitosis, and chronic aspiration. A barium swallow study is performed to confirm diagnosis. Treatment options for symptomatic patients include open surgery, as well as transoral rigid or flexible endoscopic procedures...
December 8, 2016: HNO
https://www.readbyqxmd.com/read/27933194/contribution-of-the-long-term-care-insurance-certificate-for-predicting-1-year-all-cause-readmission-compared-with-validated-risk-scores-in-elderly-patients-with-heart-failure
#2
Kayo Takahashi, Makoto Saito, Shinji Inaba, Toru Morofuji, Hiroe Aisu, Takumi Sumimoto, Akiyoshi Ogimoto, Shuntaro Ikeda, Jitsuo Higaki
OBJECTIVES: Readmission is a common and serious problem associated with heart failure (HF). Unfortunately, conventional risk models have limited predictive value for predicting readmission. The recipients of long-term care insurance (LTCI) are frail and have mental and physical impairments. We hypothesised that adjustment of the conventional risk score with an LTCI certificate enables a more accurate appreciation of readmission for HF. METHODS: We investigated 452 patients with HF who were followed up for 1 year to determine all-cause readmission...
2016: Open Heart
https://www.readbyqxmd.com/read/27933066/functionally-diverse-nk-like-t-cells-are-effectors-and-predictors-of-successful-aging
#3
REVIEW
Joshua J Michel, Patricia Griffin, Abbe N Vallejo
The fundamental challenge of aging and long-term survivorship is maintenance of functional independence and compression of morbidity despite a life history of disease. Inasmuch as immunity is a determinant of individual health and fitness, unraveling novel mechanisms of immune homeostasis in late life is of paramount interest. Comparative studies of young and old persons have documented age-related atrophy of the thymus, the contraction of diversity of the T cell receptor (TCR) repertoire, and the intrinsic inefficiency of classical TCR signaling in aged T cells...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27932873/coherence-between-self-reported-and-objectively-measured-physical-activity-in-patients-with-chronic-obstructive-lung-disease-a-systematic-review
#4
REVIEW
Mimi Thyregod, Uffe Bodtger
The beneficial effects of physical activity (PA) in patients with COPD, as well as the methods of their assessment, are well known and described. As objective measures of PA, such as the use of motion sensors, video recordings, exercise capacity testing, and indirect calorimetry, are not easily obtained in the daily clinical life, the reliability of the more accessible self-reported measurements of PA is important. In this review, we systematically identified original studies involving COPD patients and at least one parameter of self-reported and objective exercise testing, and analyzed every article for coherence between the objectively and self-reported measured PA...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27932679/tendon-collagen-synthesis-declines-with-immobilization-in-elderly-humans-no-effect-of-anti-inflammatory-medication
#5
Kasper Dideriksen, Anders Ploug Boesen, Søren Reitelseder, Christian Couppe, Rene Brüggebusch Svensson, Peter Schjerling, S Peter Magnusson, Lars Holm, Michael Kjaer
BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAID) are used as pain killers during periods of unloading caused by traumatic occurrences or diseases. However, it is unknown how the tendon protein turnover and mechanical properties responds to unloading and subsequent loading in elderly humans, and especially whether NSAIDs affect tendon adaptation during such periods. Thus, we studied the influence of NSAID upon the human patellar tendon protein synthesis and mechanical properties during immobilization and subsequent rehabilitating resistance training...
December 8, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27932359/remitting-seronegative-symmetrical-synovitis-with-pitting-oedema-rs3pe-case-presentation-and-comparison-with-other-polyarthritides-affecting-older-people
#6
Hans A Eguia, José Francisco Parodi Garcia, Covadonga Ramas Diez, Edwin A Eguia A
Remitting seronegative symmetrical synovitis with pitting oedema (RS3PE) syndrome mainly affects elderly men and responds well to steroids. Since this syndrome can resemble other diseases, its diagnosis is a significant challenge. Through the following paper, we hope to improve the diagnosis of RS3PE by presenting a table comparing RS3PE to two other common polyarthritic conditions affecting the elderly.
December 7, 2016: Age and Ageing
https://www.readbyqxmd.com/read/27932125/survival-outcomes-in-liver-transplantation-with-elderly-donors-analysis-of-andalusian-transplant-register
#7
C Cepeda-Franco, C Bernal-Bellido, L Barrera-Pulido, J M Álamo-Martínez, J H Ruiz-Matas, G Suárez-Artacho, L M Marín-Gómez, J Tinoco-González, C Díaz-Aunión, F J Padillo-Ruiz, M Á Gómez-Bravo
Recently, there has been a large discrepancy between the number of patients on the waiting list for a liver transplant and the availability of deceased donors, with an increase in annual wait list mortality rates. Elderly donor livers are thought to be marginal grafts; however, in recent years, their utilization has constantly increased. The aim of this study is to evaluate the utilization of elderly donors in Andalusia and post-transplant outcomes. This retrospective observational study of 2408 liver transplants, performed in Andalusia between 2000 and 2014, analyzes the outcomes from donors aged 70 plus (n = 423) in terms of survival rates of the graft and the recipient, the type of transplant, donor age, and D-MELD score (product of donor age and preoperative Model for End-stage Liver Disease score)...
November 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27932003/mental-health-and-related-influencing-factors-among-the-empty-nest-elderly-and-the-non-empty-nest-elderly-in-taiyuan-china-a-cross-sectional-study
#8
Y-Q Guo, C-C Zhang, H Huang, X Zheng, X-J Pan, J-Z Zheng
OBJECTIVE: In China, elderly make up a large proportion of the society, but their mental health is often overlooked. The aim of this study is to compare mental health and related influencing factors among the empty-nest and the non-empty-nest elderly, and attain the purpose of improving their quality of life. STUDY DESIGN: Cross-sectional survey. METHODS: A cross-sectional survey was conducted among 488 elderly people aged 60-92 years in six districts of Taiyuan, China...
December 2016: Public Health
https://www.readbyqxmd.com/read/27931245/brain-activation-in-frontotemporal-and-alzheimer-s-dementia-a-functional-near-infrared-spectroscopy-study
#9
Florian G Metzger, Betti Schopp, Florian B Haeussinger, Katja Dehnen, Matthis Synofzik, Andreas J Fallgatter, Ann-Christine Ehlis
BACKGROUND: Frontotemporal dementia is an increasingly studied disease, the underlying functional impairments on a neurobiological level of which have not been fully understood. Patients with the behavioral-subtype frontotemporal dementia (bvFTD) are particularly challenging for clinical measurements such as functional imaging due to their behavioral symptoms. Here, an alternative imaging method, functional near-infrared spectroscopy (fNIRS), is introduced to measure task-related cortical brain activation based on blood oxygenation...
December 8, 2016: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/27931197/reaching-the-elderly-understanding-of-health-and-preventive-experiences-for-a-tailored-approach-results-of-a-qualitative-study
#10
Christiane Patzelt, Susanne Heim, Bernhilde Deitermann, Gudrun Theile, Christian Krauth, Eva Hummers-Pradier, Ulla Walter
BACKGROUND: Often preventive measures are not accessed by the people who were intended to be reached. Programs for older adults may target men and women, older adults, advanced old age groups and/or chronically ill patients with specific indications. The defined target groups rarely participate in the conception of programs or in the design of information materials, although this would increase accessibility and participation. In the German "Reaching the Elderly" study (2008-2011), an approach to motivating older adults to participate in a preventive home visit (PHV) program was modified with the participatory involvement of the target groups...
December 8, 2016: BMC Geriatrics
https://www.readbyqxmd.com/read/27931004/increasing-trend-of-wearables-and-multimodal-interface-for-human-activity-monitoring-a-review
#11
REVIEW
Preeti Kumari, Lini Mathew, Poonal Syal
Activity recognition technology is one of the most important technologies for life-logging and for the care of elderly persons. Elderly people prefer to live in their own houses, within their own locality. If, they are capable to do so, several benefits can follow in terms of society and economy. However, living alone may have high risks. Wearable sensors have been developed to overcome these risks and these sensors are supposed to be ready for medical uses. It can help in monitoring the wellness of elderly persons living alone by unobtrusively monitoring their daily activities...
December 2, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27930519/who-are-the-users-of-a-traditional-chinese-sanfu-acupoint-herbal-patching-therapy-in-china-a-cross-sectional-survey
#12
Fen Zhou, Hong-Jun Wu, Jun-Ping Zhai, Gui-Yan Zhang, Yan Shao, Xia Tian, Ru-Yu Xia, Li-Yan Jia, Wen-Yuan Li, Ning Liang, Xiao-Yi Yan, Ruo-Han Wu, Kang Zhang, Xin-Lin Li, Cong-Cong Wang, Jian-Ping Liu
Sanfu acupoint herbal patching (SAHP) is a unique traditional Chinese medicine therapy, which has become popular for preventing acute attack of respiratory diseases such as asthma and chronic obstructive pulmonary disease, in many regions of mainland China. However, the knowledge about its users is lacking, especially the characteristics of the users and their experience and perspectives.To investigate the demographics of users, conditions for its use and the previous experience of SAHP, as well as users' perspectives to provide baseline information for its practice...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27929088/thioredoxin-interacting-protein-regulates-haematopoietic-stem-cell-ageing-and-rejuvenation-by-inhibiting-p38-kinase-activity
#13
Haiyoung Jung, Dong Oh Kim, Jae-Eun Byun, Won Sam Kim, Mi Jeong Kim, Hae Young Song, Young Kwan Kim, Du-Kyeong Kang, Young-Jun Park, Tae-Don Kim, Suk Ran Yoon, Hee Gu Lee, Eun-Ji Choi, Sang-Hyun Min, Inpyo Choi
Ageing is a natural process in living organisms throughout their lifetime, and most elderly people suffer from ageing-associated diseases. One suggested way to tackle such diseases is to rejuvenate stem cells, which also undergo ageing. Here we report that the thioredoxin-interacting protein (TXNIP)-p38 mitogen-activated protein kinase (p38) axis regulates the ageing of haematopoietic stem cells (HSCs), by causing a higher frequency of long-term HSCs, lineage skewing, a decrease in engraftment, an increase in reactive oxygen species and loss of Cdc42 polarity...
December 8, 2016: Nature Communications
https://www.readbyqxmd.com/read/27928529/the-effect-of-public-service-advertising-on-cardiovascular-disease-in-korea
#14
Juhyun Jang, Baeg Ju Na, Moo-Sik Lee, Soonryu Seo, Changhyun Sung, Hyun Joo Kim, Jin Yong Lee
BACKGROUND: Public Service Advertising (PSA) is a public interest message disseminated in the form of an advertisement communication and its main purpose is to promote public behavioral changes regarding a social issue. Korea Centers for Disease Control and Prevention (KCDC) has been delivering PSA by various media. However, the effect of PSAs has never been evaluated. The purpose of this study was to estimate the effects of broadcasted PSA produced by KCDC on cardiovascular disease (CVD)...
August 2016: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/27928224/clinical-outcomes-of-elderly-south-east-asian-patients-in-primary-percutaneous-coronary-intervention-for-st-elevation-myocardial-infarction
#15
Jieli Tong, Wen Wei Xiang, An Shing Ang, Wen Jun Sim, Kien Hong Quah, David Foo, Paul Jau Lueng Ong, Hee Hwa Ho
OBJECTIVE: To evaluate the clinical characteristics and in-hospital outcomes of elderly South-East Asian patients undergoing primary percutaneous coronary intervention (PPCI). METHODS: From January 2009 to December 2012, 1268 patients (86.4% male, mean age of 58.4 ± 12.2 years) presented to our hospital for ST-elevation myocardial infarction (STEMI) and underwent PPCI. They were divided into two groups: elderly group defined as age ≥ 70 years and non-elderly group defined as age < 70 years...
October 2016: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/27928211/use-of-heart-rate-variability-to-estimate-lactate-threshold-in-coronary-artery-disease-patients-during-resistance-exercise
#16
Rodrigo P Simões, Renata G Mendes, Viviane Castello-Simões, Aparecida M Catai, Ross Arena, Audrey Borghi-Silva
The aim of this study was to investigate whether it is possible to identify the first turn point of blood lactate (BL) concentration (1(st) lactate threshold - LT1) during a discontinuous resistance exercise protocol in coronary artery disease (CAD) patients and verify if heart rate variability (HRV) responses are consistent with BL responses. A total of 22 elderly men, 12 with CAD and 10 apparently healthy (control group = CG), underwent one-repetition maximum (1RM) testing on an inclined leg press. Discontinuous resistance exercise testing (DRET) was initiated at 10% of the 1RM with subsequent increases of 10% until 30% and after this percentage, 5% increments of 1RM was carried out...
December 2016: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/27927720/restorative-proctocolectomy-in-elderly-ibd-patients-a-multicentre-comparative-study-on-safety-and-efficacy
#17
Francesco Colombo, Saloomeh Sahami, Antony de Buck Van Overstraeten, Hagit Tulchinsky, Diane Mege, Iris Dotan, Diego Foschi, Cosimo Alex Leo, Janindra Warusavitarne, André D'Hoore, Yves Panis, Willem Bemelman, Gianluca M Sampietro
BACKGROUND AND AIMS: Restorative proctocolectomy in elderly inflammatory bowel disease [ IBD] patients is controversial and limited data are available on the outcomes of surgery. The aim of this study was to evaluate the safety, efficacy, and long-term results of ileal-pouch-anal anastomosis in elderly patients, in a multicentre survey from European referral centres. METHODS: The International Pouch Database [IPD] combined 101 variables. Patients aged ≥ 65 years were matched on the basis of open versus laparoscopic surgery with a control group of consecutive younger unselected patients with a ratio of 1:2...
December 7, 2016: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/27927714/contemporary-assessment-of-left-ventricular-diastolic-function-in-older-adults-the-atherosclerosis-risk-in-communities-study
#18
Amil M Shah, Brian Claggett, Dalane Kitzman, Tor Biering-Sørensen, Jan S Jensen, Susan Cheng, Kunihiro Matsushita, Suma H Konety, Aaron R Folsom, Thomas H Mosley, Jacqueline Wright, Gerardo Heiss, Scott D Solomon
BACKGROUND: -While age-associated changes in LV diastolic function are well-recognized, limited data exist characterizing measures of diastolic function in older adults, including both reference ranges reflecting the older adult population and prognostically relevant values for incident HF, as well as their associations with circulating biomarkers of heart failure (HF) risk. METHODS: -Among 5,801 elderly participants in the Atherosclerosis Risk in Communities (ARIC) study (age range 67-90, mean age 76 ± 5, 42% male, 21% black), we determined the continuous association of diastolic measures (TDI e', E/e', and left atrial size) with concomitant NT-proBNP and subsequent HF hospitalization or death...
December 7, 2016: Circulation
https://www.readbyqxmd.com/read/27927637/options-for-basing-dietary-reference-intakes-dris-on-chronic-disease-endpoints-report-from-a-joint-us-canadian-sponsored-working-group
#19
REVIEW
Elizabeth A Yetley, Amanda J MacFarlane, Linda S Greene-Finestone, Cutberto Garza, Jamy D Ard, Stephanie A Atkinson, Dennis M Bier, Alicia L Carriquiry, William R Harlan, Dale Hattis, Janet C King, Daniel Krewski, Deborah L O'Connor, Ross L Prentice, Joseph V Rodricks, George A Wells
Dietary Reference Intakes (DRIs) are used in Canada and the United States in planning and assessing diets of apparently healthy individuals and population groups. The approaches used to establish DRIs on the basis of classical nutrient deficiencies and/or toxicities have worked well. However, it has proved to be more challenging to base DRI values on chronic disease endpoints; deviations from the traditional framework were often required, and in some cases, DRI values were not established for intakes that affected chronic disease outcomes despite evidence that supported a relation...
December 7, 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27927620/ambient-fine-particulate-matter-outdoor-temperature-and-risk-of-metabolic-syndrome
#20
Rachel S Wallwork, Elena Colicino, Jia Zhong, Itai Kloog, Brent A Coull, Pantel Vokonas, Joel D Schwartz, Andrea A Baccarelli
Ambient air pollution and temperature have been linked with cardiovascular morbidity and mortality. Metabolic syndrome and its components-abdominal obesity, elevated fasting blood glucose concentration, low high-density lipoprotein cholesterol concentration, hypertension, and hypertriglyceridemia-predict cardiovascular disease, but the environmental causes are understudied. In this study, we prospectively examined the long-term associations of air pollution, defined as particulate matter with an aerodynamic diameter less than or equal to 2...
December 7, 2016: American Journal of Epidemiology
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