Valentina Canini, Albino Eccher, Giulia d'Amati, Nicola Fusco, Fausto Maffini, Daniela Lepanto, Maurizio Martini, Giorgio Cazzaniga, Panagiotis Paliogiannis, Renato Lobrano, Vincenzo L'Imperio, Fabio Pagni
The assessment of programmed death-ligand 1 (PD-L1) combined positive scoring (CPS) in head and neck squamous cell carcinoma (HNSCC) is challenged by pre-analytical and inter-observer variabilities. An educational program to compare the diagnostic performances between local pathologists and a board of pathologists on 11 challenging cases from different Italian pathology centers stained with PD-L1 immunohistochemistry on a digital pathology platform is reported. A laboratory-developed test (LDT) using both 22C3 (Dako) and SP263 (Ventana) clones on Dako or Ventana platforms was compared with the companion diagnostic (CDx) Dako 22C3 pharm Dx assay...
February 22, 2024: Journal of Clinical Medicine