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Pathology Consultation

Ramona Erber, Abbas Agaimy
Although harmless, reactive and benign neoplastic myo-/fibroblastic proliferations represent a diagnostic challenge in routine surgical pathology practice as reflected by their frequency among consultation cases. In addition to resembling each other, the prototypical nodular fasciitis (NF) and NF-like lesions can be mistaken for low-grade or aggressive sarcomas. USP6 translocation was reported recently as the molecular driver and potential diagnostic marker of NF. We reviewed 71 lesions with a diagnosis of NF (n = 48) or NF-like myofibroblastic proliferations (n = 23) and screened them for USP6 translocation by fluorescence in situ hybridization (FISH)...
April 5, 2018: Virchows Archiv: An International Journal of Pathology
Francisco Javier Formigo Couceiro, Marta Pena Seijo, Antonio Pose Reino, José Manuel Mayán Santos, Francisco Javier Ayape Amigot, Jesús Sueiro Justel
OBJECTIVE: To estimate the prevalence of orthostatic hypotension (OH) in patients 80 years old and over attending a primary care unit. To relate OH to the most prevalent pathologies and to the most used drugs. DESIGN: Transversal observational study. LOCATION: Primary care unit, Santiago de Compostela. PARTICIPANTS: Eighty one patients 80 years old or over representative of a primary care unit were recruited. Ten patients were excluded...
March 30, 2018: Atencion Primaria
Claire Hentzen, Rebecca Haddad, Samer Sheikh Ismael, Benoit Peyronnet, Xavier Gamé, Pierre Denys, Gilberte Robain, Gérard Amarenco
PURPOSE: The main goal of this retrospective study is to explore the predictors of success in learning clean intermittent self-catheterization (CISC) in patients over 65 years of age. The secondary goal is to assess whether in this population, the risk of failure to perform CISC is greater, compared with patients under 65 with similar pathologies. METHODS: All patients older than 65 consulting between January 2011 and January 2016 for learning CISC were included...
March 2018: International Neurourology Journal
Trh Read, S Walker, Epf Chow, J J Ong, C S Bradshaw, N A Medland, R Wigan, M Y Chen, C K Fairley
BACKGROUND: Increasing the frequency of HIV testing among men who have sex with men (MSM), maximises the preventive effect of antiretroviral therapy, by reducing time to diagnosis and treatment. SETTING: Melbourne Sexual Health Centre, Australia. METHODS: This randomised controlled trial evaluated whether access to testing,without seeing a clinician, would increase testing frequency. MSM attending for HIV testing between July 2014 and April 2015 were randomised 1:1 to the intervention (access to HIV and syphilis testing at 300 pathology centres, without requiring consultations) or the control arm (consultation at every test), without blinding...
March 29, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Nikolay L Martirosyan, Joseph Georges, Jennifer M Eschbacher, Evgenii Belykh, Alessandro Carotenuto, Robert F Spetzler, Peter Nakaji, Mark C Preul
OBJECTIVES: Frozen section histological analysis is currently the mainstay for intraprocedural tissue diagnosis during the resection of intracranial neoplasms and for evaluating tumor margins. However, frozen sections are time-consuming and often do not reveal the histological features needed for final diagnosis when compared with permanent sections. Confocal scanning microscopy (CSM) with certain stains may be a valuable technology that can add rapid and detailed histological assessment advantage for the neurosurgical operating room...
March 21, 2018: Clinical Neurology and Neurosurgery
Ajesh B Maharaj, Pragalathan Naidoo, Terisha Ghazi, Naeem S Abdul, Shanel Dhani, Taskeen F Docrat, Prithiksha Ramkaran, Paul-Peter Tak, Niek de Vries, Anil A Chuturgoon
BACKGROUND: Psoriasis and psoriatic arthritis (PsA) are inflammatory associated autoimmune disorders. MicroRNA (miR)-146a plays a crucial role in regulating inflammation. A single nucleotide polymorphism in the miR-146a gene (rs2910164), aberrantly alters its gene expression and linked with the pathogenesis of several disorders, including psoriasis and PsA. In South Africa, psoriasis and PsA are extremely rare in the indigenous African population and most common in both the Indian and Caucasian population...
March 27, 2018: BMC Medical Genetics
Bellal Joseph, Faisal Jehan, Michael Dacey, Narong Kulvatunyou, Muhammad Khan, Muhammad Zeeshan, Lynn Gries, Terence O'Keeffe, Taylor S Riall
BACKGROUND: The Tokyo Guidelines (TG13) is used to diagnose, grade severity, and guide management of acute cholecystitis (AC). Aim of our study was to verify the diagnostic criteria, severity assessment, and management protocols based on TG13. STUDY DESIGN: Our prospectively maintained Emergency General Surgery registry was utilized to review patients who had a surgical consultation for RUQ pain (2013-2015). Diagnosis and severity were graded based on TG13 and compared with pathology report...
March 23, 2018: Journal of the American College of Surgeons
Clare Verrill, Joanna Perry-Keene, John R Srigley, Ming Zhou, Peter A Humphrey, Antonio Lopez-Beltran, Lars Egevad, Thomas M Ulbright, Satish K Tickoo, Jonathan I Epstein, Eva Compérat, Daniel M Berney
The International Society of Urological Pathology held a conference on issues in testicular and penile pathology in Boston in March 2015, which included a presentation by the testis macroscopic features working group. The presentation focused on current published guidance for macroscopic handling of testicular tumors and retroperitoneal lymph node dissections with a summary of results from an online survey of members preceding the conference. The survey results were used to initiate discussions, but decisions on practice were made by expert consensus rather than voting...
March 23, 2018: American Journal of Surgical Pathology
Emily A Goebel, Helen Ettler, Joanna C Walsh
Intradepartmental consultations (ICs) are important for quality assurance (QA) and ensuring diagnostic accuracy in surgical pathology. Few studies have reviewed pathologist factors that influence IC rates. Our study reviews IC data and factors that influence both formal (written) and informal (verbal) consultation practices among pathologists in academic and community hospital settings. Formal IC records from the academic hospital were collected and academic and community pathologists were invited to complete a survey about their IC practices...
February 21, 2018: Pathology, Research and Practice
Ravi Shah, Rahel Eynan, Marnin J Heisel, David Eden, Reuven Jhirad, Paul S Links
Objective: To describe sociodemographic and clinical characteristics of suicide decedents and to explore the pattern of clinical and suicide risk assessment in primary care settings. Methods: A 3-year case series of consecutive suicides (January 1, 2012, to December 31, 2014) in Southwestern Ontario, Canada, identified by the Office of the Chief Coroner of Ontario and Ontario Forensic Pathology Service (OCC/OFPS) was conducted. Clinicians who provided care to suicide decedents completed a confidential suicide questionnaire offered online through a secured portal or by hardcopy...
March 8, 2018: Primary Care Companion to CNS Disorders
J Chase McNeil, Jesus G Vallejo, Kristina G Hulten, Sheldon L Kaplan
BACKGROUND: Most cases of pediatric osteoarticular infections (OAI) are hematogenous in nature and caused by Staphylococcus aureus. OAI in children can also occur through direct inoculation of microorganisms secondary to penetrating or open trauma. No studies in the US have evaluated the microbiology or outcomes of trauma-related OAI (TROAI) in children in the era of community-acquired MRSA (CA-MRSA). METHODS: Cases were identified from the inpatient infectious diseases consultation database at Texas Children's Hospital from Jan 2011-Dec 2016...
March 21, 2018: Pediatric Infectious Disease Journal
Jeffrey A Zuccato, Christopher D Witiw, Julia Keith, Erin Dyer, Arjun Saghal, Leodante da Costa
Introduction: Pre-operative biopsy and diagnosis of chordomas of the mobile spine is indicated as en bloc resections improve outcomes. This review of the management of mobile spine chordomas includes two cases of unexpected mobile spine chordomas where a preoperative tissue diagnosis was decided against and may have altered surgical decision-making. Case presentation: Two lumbar spine chordomas thought to be metastatic and primary bony lesions preoperatively were not biopsied before surgery and eventual pathology revealed chordoma...
2018: Spinal Cord Series and Cases
Karine Danno, Gérard Duru, Jean Marie Vetel
BACKGROUND:  The increasing use of psychotropic drugs to treat anxiety and depressive disorders (ADDs) is concerning. According to the study, 'Etude Pharmacoépidémiologique de l'Impact de Santé Publique des modes de prise en charge pour 3 groupes de pathologies' (EPI3)-LASER, adult ADD patients who consult a general practitioner prescribing homeopathic medicines (GP-Ho) report less psychotropic drug use and are marginally more likely to experience clinical improvement than those receiving conventional care...
March 20, 2018: Homeopathy: the Journal of the Faculty of Homeopathy
Guillermo Benítez, Martí March-Salas, Alberto Villa-Kamel, Ulises Cháves-Jiménez, Javier Hernández, Nuria Montes-Osuna, Joaquín Moreno-Chocano, Paloma Cariñanos
ETHNOPHARMACOLOGICAL RELEVANCE: The different species of the genus Datura have been used traditionally by some pre-Columbian civilizations, as well as in medieval rituals linked to magic and witchcraft in both Mexico and Europe. It is also noteworthy the use of different alkaloids obtained from the plants for medicinal purposes in the treatment of various groups of diseases, especially of the respiratory and muscularskeletal systems. AIM OF THE STUDY: A review of the ethnobotanical uses of the genus Datura in Mexico and Spain has been conducted...
March 15, 2018: Journal of Ethnopharmacology
Germán Errázuriz
INTRODUCTION: Rectal prolapse (RP) is related to an increase of intra-abdominal pressure, pelvic floor disease or anal sphincter. The most common causes of RP are constipation, cystic fibrosis, whooping cough and dysenteric diarrhea. However, celiac disease is not considered among the pathologies re lated to RP. OBJECTIVE: To present a scarcely described association between RP and celiac disease. CLINICAL CASES: We presented 2 preschoolers in whom the reason for consultation was RP, whose study was focused on as prolonged diarrhea, due to the antecedent of pasty consistency of stools...
December 2017: Revista Chilena de Pediatría
Haifa A Al-Turki
OBJECTIVES: To evaluate the use of hysteroscopy in the assessment of uterine pathologies in infertile women with repeated implantation failure (RIF) after in vitro fertilization (IVF) and determine whether removal of such pathologies increased pregnancy rates in women with RIF. METHODS: This prospective study was conducted at King Fahd Hospital of the University, Al-Khobar, Kingdom of Saudi Arabia, between January 2010 and December 2015. The inclusion criteria were women who underwent IVF treatment cycles and ended in more than 2 RIF, and women who underwent hysterosalpingography (HSG)...
March 2018: Saudi Medical Journal
V Campbell, R Beckett, N Abid, S Hoey
Infantile hepatic hemangiomas (IHH), particularly of the diffuse subtype, can in severe cases be associated with hepatic and cardiac failure, compartment syndrome, and consumptive hypothyroidism. Early recognition and treatment of these pathologies is paramount in order to minimise the risk of longterm sequelae. We report an interesting case of a female infant who presented with systemic compromise, in the absence of large or obvious cutaneous infantile hemangiomas (IH). Imaging identified innumerable hepatic hemangiomas, consistent with diffuse infantile hepatic hemangiomatosis...
February 28, 2018: Journal of Clinical Research in Pediatric Endocrinology
Avinoam Nevler, Yaniv Berger, Avital Rabinovitz, Oded Zmora, Moshe Shabtai, Danny Rosin, Mordechai Gutman
BACKGROUND: Acute appendicitis (AA) is one of the most common indications for emergency abdominal surgery. OBJECTIVES: To assess the diagnostic and prognostic value of serum bilirubin and liver enzyme levels in the management of acute appendicitis. METHODS: Consecutive emergency department patients referred for a surgical consult for suspected AA were prospectively enrolled in the study. Data regarding demographic, clinical and laboratory results were recorded...
March 2018: Israel Medical Association Journal: IMAJ
James Watson, Robert M Barker-Davies, Alexander N Bennett, Daniel T P Fong, Patrick C Wheeler, Mark Lewis, Craig Ranson
Objective: Several lower limb tendinopathy treatment modalities involve identification of pathological paratendinous or intratendinous neovascularisation to target proposed co-location of painful neoneuralisation. The ability to reliably locate and assess the degree of neovascularity is therefore clinically important. The Modified Ohberg Score (MOS) is frequently used to determine degree of neovascularity, but reliability has yet to be established among Sport and Exercise Medicine (SEM) consultants...
2018: BMJ Open Sport & Exercise Medicine
S H Hancox, J D Sinnott, P Kirkland, D Lipscomb, E Owens, D C Howlett
OBJECTIVE: A parathyroid multidisciplinary team meeting was set up at East Sussex Healthcare Trust, from November 2014 to November 2015, in order to improve and streamline services for patients with parathyroid pathology. METHODS: Data were collected on all new referrals for hyperparathyroidism, and on the outcomes for each patient discussed at the meeting, including the number of operations and management outcomes. A survey was sent out to the members of the multidisciplinary team meeting to determine their perception of its effectiveness...
March 2018: Journal of Laryngology and Otology
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