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https://www.readbyqxmd.com/read/29143560/induced-pluripotent-stem-cells-derived-from-human-amnion-in-chemically-defined-conditions
#1
Jaroslav Slamecka, Steven McClellan, Anna Wilk, Javier Laurini, Elizabeth Manci, Simon P Hoerstrup, Benedikt Weber, Laurie Owen
Fetal stem cells are a unique type of adult stem cells that have been suggested to be broadly multipotent with some features of pluripotency. Their clinical potential has been documented but their upgrade to full pluripotency could open up a wide range of cell-based therapies particularly suited for pediatric tissue engineering, longitudinal studies or disease modeling. Here we describe episomal reprogramming of mesenchymal stem cells from the human amnion to pluripotency (AM-iPSC) in chemically defined conditions...
November 16, 2017: Cell Cycle
https://www.readbyqxmd.com/read/29104392/association-between-fever-and-primary-tooth-eruption-a-systematic-review-and-meta-analysis
#2
REVIEW
Mariana A Nemezio, Katharina Mh De Oliveira, Priscilla C Romualdo, Alexandra M Queiroz, Francisco Wg Paula-E-Silva, Raquel Ab Silva, Erika C Küchler
Aim: To perform a systematic review and meta-analysis to establish if fever is associated with primary tooth eruption. Materials and methods: Literature searches involved Pubmed, MEDLINE, Web of Science, Scopus and Cochrane. The potentially relevant studies had the full text analyzed. Only studies concerning fever during eruption period of primary tooth in humans were included. Papers in non-English language, and papers that included syndromic patients or patients with any disease were excluded...
July 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/29104386/effect-of-casein-phosphopeptide-amorphous-calcium-phosphate-and-calcium-sodium-phosphosilicate-on-artificial-carious-lesions-an-in-vitro-study
#3
Iqra Chaudhary, Abhay M Tripathi, Gunjan Yadav, Sonali Saha
Aim: To compare new remineralizing agents calcium sodium phosphosilicate paste and casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) paste with that of fluoridated toothpaste in remineralization of early carious lesions using scanning electron microscopy and energy-dispersive X-ray (SEM-EDX) analysis. Materials and methods: Sixty sound extracted premolars were collected and placed in demineralizing solution for 4 days to produce artificial carious lesions...
July 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/29063541/best-paper-selection
#4
(no author information available yet)
Bahous MC, Shadmi E. Health information exchange and information gaps in referrals to a pediatric emergency department. Int J Med Inform 2016;87:68-74 https://linkinghub.elsevier.com/retrieve/pii/S1386-5056(15)30078-2 Esmaeilzadeh P, Sambasivan M. Health Information Exchange (HIE): A literature review, assimilation pattern and a proposed classification for a new policy approach. J Biomed Inform 2016;64:74-86 http://www.sciencedirect.com/science/article/pii/S1532046416301241?via%3Dihub Massoudi BL, Marcial LH, Tant E, Adler-Milstein J, West SL...
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29039850/systematic-review-disease-activity-indices-in-eosinophilic-esophagitis
#5
REVIEW
Marijn J Warners, Pieter Hindryckx, Barrett G Levesque, Claire E Parker, Lisa M Shackelton, Reena Khanna, William J Sandborn, Geert R D'Haens, Brian G Feagan, Albert J Bredenoord, Vipul Jairath
OBJECTIVES: There is no clear consensus regarding the most appropriate measure(s) of eosinophilic esophagitis (EoE) disease activity. We aimed to identify all scoring indices used for the measurement of disease activity in EoE, appraise their operating properties, and discuss their value as outcome measures. METHODS: MEDLINE, EMBASE, and CENTRAL (The Cochrane library) were searched from inception to 11 May 2016. Randomized controlled trials (RCTs), cohort, case-control, and cross-sectional studies that reported outcomes to measure EoE disease activity or response to treatment were eligible...
November 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29020247/assessment-of-efficacy-and-safety-of-arterolane-maleate-piperaquine-phosphate-dispersible-tablets-in-comparison-with-artemether-lumefantrine-dispersible-tablets-in-pediatric-patients-with-acute-uncomplicated-plasmodium-falciparum-malaria-a-phase-3-randomized
#6
Offianan Andre Toure, Victor Mwapasa, Issaka Sagara, Oumar Gaye, Ricardo Thompson, Aishwarya V Maheshwar, Pitabas Mishra, Narendra Behra, Antoinette K Tshefu, Rashmi R Das, Anupkumar R Anvikar, Pradeep Sharma, Arjun Roy, Sanjay K Sharma, Amit Nasa, Rajinder K Jalali, Neena Valecha
Background: Administration of artemisinin-based combination therapy (ACT) to infant and young children can be challenging. A formulation with accurate dose and ease of administration will improve adherence and compliance in children. The fixed-dose combination dispersible tablet of arterolane maleate (AM) 37.5 mg and piperaquine phosphate (PQP) 187.5 mg can make dosing convenient in children. Methods: This multicenter (India and Africa), comparative, parallel-group trial enrolled 859 patients aged 6 months to 12 years with Plasmodium falciparum malaria...
August 29, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28950047/-it-s-not-who-i-am-children-s-experiences-of-growing-up-with-a-long-term-condition-in-england-australia-and-new-zealand
#7
Bernie Carter, Karen Ford, Lucy Bray, Tineke Water, Janine Arnott, Cassandra Tichanow, Annette Dickinson
PURPOSE: Most studies of growing up with a long-term condition focus on older children and adolescents and are condition-specific. Relatively few studies address the experiences of children in middle childhood or consider their experience across a range of conditions, countries, and health settings. This study aimed to explore children's perceptions and understandings of how their lives are shaped (or not) by a long-term condition and its associated management. DESIGN AND METHODS: A qualitative, participatory methodology using autodriven photoelicitation interviews (PEIs) with 45 purposively recruited children (6-12 years) with long-term conditions (e...
September 26, 2017: Journal for Specialists in Pediatric Nursing: JSPN
https://www.readbyqxmd.com/read/28933929/diagnostic-accuracy-of-two-food-insecurity-screeners-recommended-for-use-in-health-care-settings
#8
Jennifer A Makelarski, Emily Abramsohn, Jasmine H Benjamin, Senxi Du, Stacy Tessler Lindau
OBJECTIVES: To test the diagnostic accuracy of the American Academy of Pediatrics (AAP) recommended food insecurity screener. METHODS: We conducted prospective diagnostic accuracy studies between July and November 2016 in Chicago, Illinois. We recruited convenience samples of adults from adult and pediatric emergency departments (12-month recall study: n = 188; 30-day recall study: n = 154). A self-administered survey included the 6-item Household Food Security Screen (gold standard), the validated 2-item Hunger Vital Sign (HVS; often, sometimes, never response categories), and the 2-item AAP tool (yes-or-no response categories)...
November 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28888498/parental-expectations-of-support-from-healthcare-providers-during-pediatric-life-threatening-illness-a-secondary-qualitative-analysis
#9
Kim Mooney-Doyle, Maiara Rodrigues Dos Santos, Regina Szylit, Janet A Deatrick
PURPOSES: To explain parental expectations of support from healthcare providers for their parenting roles and goals during a child's life-threatening illness (LTI). DESIGN AND METHODS: Qualitative interpretive study guided by the Family Adjustment and Adaptation Response Model. Thematic analyses were conducted with data from 31 semi-structured interviews of parents of children with LTI using systematic strategies to ensure rigor including audit trails and prolonged engagement...
September 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28841573/pediatric-providers-attitudes-and-practices-regarding-concussion-diagnosis-and-management
#10
Khalida Itriyeva, Ronald Feinstein, Linda Carmine
Background Concussions, a form of mild traumatic brain injury, are a current "hot topic" in sports and medicine, with current research focusing on diagnosis, treatment, and the long-term effects of repeated concussions on development of chronic traumatic encephalopathy. Concussions represent 8.9% of all high school athletic injuries, and pediatricians see many of these patients in their practices, however evolving guidelines and recommendations have resulted in varying practices among providers. Objective To assess how local pediatricians in New York Chapter 2 of the American Academy of Pediatrics (AAP) diagnose and treat concussion patients, and to evaluate the need for continuing education in this area...
August 25, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/28817337/oral-health-integration-into-a-pediatric-practice-and-coordination-of-referrals-to-a-colocated-dental-home-at-a-federally-qualified-health-center
#11
Nandini Sengupta, Sonal Nanavati, Maria Cericola, Lisa Simon
We have integrated preventive oral health measures into preventive care visits for children at a federally qualified health center in Boston, Massachusetts. The program, started in 2015, covers 3400 children and has increased universal caries risk screening in primary care to 85%, fluoride varnish application rates to 80%, and referrals to a dental home to 35%. We accomplished this by minimizing pressures on providers' workflow, empowering medical assistants to lead the initiative, and utilizing data-driven improvement strategies, alongside colocated coordinated care...
October 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28809388/dramatic-increase-in-incidence-of-ulcerative-colitis-and-crohn-s-disease-1988-2011-a-population-based-study-of-french-adolescents
#12
Silvia Ghione, Hélène Sarter, Mathurin Fumery, Laura Armengol-Debeir, Guillaume Savoye, Delphine Ley, Claire Spyckerelle, Benjamin Pariente, Laurent Peyrin-Biroulet, Dominique Turck, Corinne Gower-Rousseau
OBJECTIVES: Few data are available to describe the changes in incidence of pediatric-onset inflammatory bowel disease (IBD). The aim of this study was to describe changes in incidence and phenotypic presentation of pediatric-onset IBD in northern France during a 24-year period. METHODS: Pediatric-onset IBD (<17 years) was issued from a population-based IBD study in France between 1988 and 2011. Age groups and digestive location were defined according to the Paris classification...
August 15, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28743679/exploring-the-association-between-self-reported-asthma-impact-and-fitbit-derived-sleep-quality-and-physical-activity-measures-in-adolescents
#13
Jiang Bian, Yi Guo, Mengjun Xie, Alice E Parish, Isaac Wardlaw, Rita Brown, François Modave, Dong Zheng, Tamara T Perry
BACKGROUND: Smart wearables such as the Fitbit wristband provide the opportunity to monitor patients more comprehensively, to track patients in a fashion that more closely follows the contours of their lives, and to derive a more complete dataset that enables precision medicine. However, the utility and efficacy of using wearable devices to monitor adolescent patients' asthma outcomes have not been established. OBJECTIVE: The objective of this study was to explore the association between self‑reported sleep data, Fitbit sleep and physical activity data, and pediatric asthma impact (PAI)...
July 25, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28737600/an-interprofessional-quality-improvement-initiative-to-standardize-pediatric-extubation-readiness-assessment
#14
Samer Abu-Sultaneh, Acrista J Hole, Alvaro J Tori, Brian D Benneyworth, Riad Lutfi, Christopher W Mastropietro
OBJECTIVES: Establishing protocols to wean mechanical ventilation and assess readiness for extubation, with the goal of minimizing morbidity associated with extubation failure and prolonged mechanical ventilation, have become increasingly important in contemporary PICUs. The aim of this quality improvement initiative is to establish a respiratory therapist-led daily spontaneous breathing trial protocol to standardize extubation readiness assessment and documentation in our PICU. DESIGN: A quality improvement project...
October 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28727535/civil-unrest-in-the-context-of-chronic-community-violence-impact-on-maternal-depressive-symptoms
#15
Doris P Yimgang, Yan Wang, Grace Paik, Erin R Hager, Maureen M Black
OBJECTIVES: To examine changes in maternal-child health surrounding the April 2015 civil unrest in Baltimore, Maryland, following Freddie Gray's death while in police custody. METHODS: We conducted cross-sectional Children's HealthWatch surveys January 2014 through December 2015 in pediatric emergency departments and primary care clinics on maternal-child health and June 2015 through October 2015 on daily and community routines. We used trend analysis and piecewise logistic regression to examine effects of time, residential proximity moderation, and mediation analysis to assess proximity and maternal-child health relations via maternal concerns...
September 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28664445/pediatric-cardiology-provider-attitudes-about-palliative-care-a-multicenter-survey-study
#16
Emily Morell Balkin, James N Kirkpatrick, Beth Kaufman, Keith M Swetz, Lynn A Sleeper, Joanne Wolfe, Elizabeth D Blume
While availability of palliative care consultation for children with advanced heart disease increases, little is known about cardiologist attitudes towards palliative care. We sought to describe perspectives of cardiologists regarding palliative care and to characterize their perceived competence in palliative care concepts. A cross-sectional survey of pediatric cardiologists and cardiac surgeons from 19 pediatric medical centers was performed. Overall response rate was 31% (183/589). Respondents had a median of 18 years of experience since medical school (range 2-49) and most practiced at academic centers (91%)...
June 29, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28658184/improving-compliance-in-obtaining-daily-weights-in-a-large-academic-children-s-hospital
#17
Jacqueline E Crawford, Colleen Garvin Coyne, Katherine Calder
Noncompliance in obtaining daily weights leads to delays in establishing treatment and discharge plans in pediatric populations. An inpatient gastrointestinal and endocrine nursing unit aimed to increase compliance of obtaining daily weights from baseline of 38% to 80%. The time daily weights were obtained was changed from 8 AM to an interval of time 4 PM to 6 PM. The compliance rate increased to 96% and has been sustained at an average of 94% over 24 months. This report describes a low-risk intervention that took minimal effort to implement but yielded high results to exceed the goal...
June 23, 2017: Journal of Nursing Care Quality
https://www.readbyqxmd.com/read/28650780/i-am-a-pediatric-dentist-why-is-substance-abuse-among-my-patients-my-concern
#18
H Barry Waldman, Steven P Perlman
The rapidly evolving demographic base of our communities intensifies the need for an awareness which in the past seemed beyond the traditional concerns of pediatric dentists; in this case, substance abuse by teenagers. A review was carried out regarding evolving demographics, the proportion of teenagers involved with substance abuse, the rationale for the use of varying elicit substances and the associated symptoms. A series of options for action are considered given the potential for pediatric dentists to be involved in the care of teenagers using elicit substances...
2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28639991/evaluation-of-a-nutritional-support-intervention-in-malnourished-hiv-infected-children-in-bamako-mali
#19
Julie Jesson, Aba Coulibaly, Mariam Sylla, Clémentine NʼDiaye, Fatoumata Dicko, David Masson, Valériane Leroy
BACKGROUND: We assessed a nutritional support intervention in malnourished HIV-infected children in a HIV-care program of the University Hospital Gabriel Touré, Bamako, Mali. METHODS: All HIV-infected children younger than 15 years were diagnosed for malnutrition between 07 and 12, 2014. Malnutrition was defined according to the WHO growth standards with Z-scores. Two types were studied: acute malnutrition (AM) and chronic malnutrition (CM). All participants were enrolled in a 6-month prospective interventional cohort, receiving Ready-To-Use Therapeutic Food, according to type of malnutrition...
October 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28578536/population-pharmacokinetic-and-exposure-response-analyses-of-prasugrel-in-pediatric-patients-with-sickle-cell-anemia
#20
Brian A Moser, Elizabeth S LaBell, Emmanuel Chigutsa, Joseph A Jakubowski, David S Small
BACKGROUND AND OBJECTIVE: Prasugrel, a P2Y12 adenosine diphosphate (ADP) receptor antagonist, inhibits ADP-mediated platelet activation and aggregation in patients with sickle cell anemia (SCA). We developed a population pharmacokinetic (popPK) model in pediatric patients from 2 to <18 years of age with SCA, and performed exposure-response evaluations to characterize the effects of prasugrel in a subset of these patients who weighed 19 kg or more and experienced at least two episodes of vaso-occlusive crises (VOC) in the past year...
June 3, 2017: Clinical Pharmacokinetics
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