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chlorogenic acid

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https://www.readbyqxmd.com/read/29146180/chlorogenic-acid-attenuates-diabetic-retinopathy-by-reducing-vegf-expression-and-inhibiting-vegf-mediated-retinal-neoangiogenesis
#1
Xiyu Mei, Lingyu Zhou, Tianyu Zhang, Bin Lu, Yuchen Sheng, Lili Ji
Diabetic retinopathy (DR) is one of the most common and serious complications of diabetes mellitus (DM). This study aims to investigate the amelioration of chlorogenic acid (CGA) on proliferative DR (PDR) via focusing on inhibiting retinal neoangiogenesis. CGA reduced the increased cell proliferation, migration and tube formation induced by vascular endothelial growth factor (VEGF) in human retinal endothelial cells (HREC) and choroid-retinal endothelial RF/6A cells. CGA abrogated VEGF-induced the phosphorylation of VEGFR2 and its downstream mitogen-activated extracellular regulated kinase (MEK1/2), extracellular regulated protein kinase (ERK1/2) and p38 kinase...
November 13, 2017: Vascular Pharmacology
https://www.readbyqxmd.com/read/29145070/arsenic-forms-and-their-combinations-induce-differences-in-phenolic-accumulation-in-ulmus-laevis-pall
#2
Kinga Drzewiecka, Monika Gąsecka, Paweł Rutkowski, Zuzanna Magdziak, Piotr Goliński, Mirosław Mleczek
Total phenolics and the profile of phenolic acids and flavonoids were investigated in the roots and leaves of Ulmus laevis cultured on the medium with inorganic and organic arsenic - As(III), As(V) and DMA(V) at 0.06mM and their equimolar combinations. Further, the accumulation of salicylic acid (free and glucoside-bound) and lipid oxidation were assayed following a three-month long experiment. As treatment caused elevated production of phenolics, which was higher in photosynthetic tissue than in roots for all As forms and their combinations, and their overall content was correlated with the accumulation of organic As in roots and As(III) in leaves...
November 11, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29142422/chemotaxonomic-diversity-of-three-ficus-species-their-discrimination-using-chemometric-analysis-and-their-role-in-combating-oxidative-stress
#3
Nawal Al-Musayeib, Sherif S Ebada, Haidy A Gad, Fadia S Youssef, Mohamed Lotfy Ashour
Background: Genus Ficus (Moraceae) constitutes more than 850 species and about 2000 varieties and it acts as a golden mine that could afford effective and safe remedies combating many health disorders. Objectives: Discrimination of Ficus cordata, Ficus ingens, and Ficus palmata using chemometric analysis and assessment of their role in combating oxidative stress. Materials and Methods: Phytochemical profiling of the methanol extracts of the three Ficus species and their successive fractions was performed using high-performance liquid chromatography/electrospray ionization mass spectrometry...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29142394/antioxidant-phytochemicals-of-opuntia-ficus-indica-l-mill-cladodes-with-potential-anti-spasmodic-activity
#4
Francesco Lanuzza, Francesco Occhiuto, Maria Teresa Monforte, Maria Marcella Tripodo, Valeria D'Angelo, Enza Maria Galati
Background: Opuntia ficus-indica (OFI) (L.) Mill. (Cactaceae), a plant widespread in dry regions of the world, shows interesting biological activities (cicatrizant, antiulcer, anti-inflammatory, and hypolipidemic) and is widely used in traditional medicine. Objectives: Phytochemical analysis and antispasmodic effect of wild OFI cladodes were carried out. Material and Methods: Polyphenols and Vitamin E occurrence, in antioxidant pool of OFI cladodes, were quantified by high-performance liquid chromatography...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29141471/dietary-chlorogenic-acid-regulates-gut-microbiota-serum-free-amino-acids-and-colonic-serotonin-levels-in-growing-pigs
#5
Yi Wu, Wenhui Liu, Qi Li, Yafei Li, Yali Yan, Fang Huang, Xin Wu, Quancheng Zhou, Xugang Shu, Zheng Ruan
Chlorogenic acid (CGA) has many biological properties, including antibacterial, antioxidant and anti-inflammatory properties, and is one of the most abundant phenolic acids available in the human diet. The aim of this study was to investigate the effects of CGA on regulation of the gut microbiota, and on the levels of free amino acids and 5-hydroxytryptamine (5-HT, serotonin). Ninety-six healthy growing pigs were randomly assigned to two treatment groups: the Ctrl group (control group, standard feed) and the CGA group [standard feed plus 0...
November 15, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/29136249/natural-polyphenol-chlorogenic-acid-protects-against-acetaminophen-induced-hepatotoxicity-by-activating-erk-nrf2-antioxidative-pathway
#6
Mengjuan Wei, Zhiyong Zheng, Liang Shi, Yao Jin, Lili Ji
Hepatotoxicity due to acetaminophen (APAP) overdose is a leading cause of drug-induced acute liver failure in clinic. Chlorogenic acid (CGA), a dietary polyphenol, was reported to prevent APAP-induced liver injury in our previous studies. This study aims to investigate the protection provided by CGA against APAP-induced hepatotoxicity via focusing on nuclear factor erythroid 2-related factor 2 (Nrf2) and extracellular regulated protein kinases (ERK)1/2. CGA prevented APAP-induced oxidative liver injury and enhanced Nrf2 activation in mice and in hepatocytes in vitro...
November 10, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29129054/the-mulberry-morus-alba-l-fruit-a-review-of-characteristic-components-and-health-benefits
#7
Qingxia Yuan, Longyan Zhao
Mulberry (Morus alba L.) fruit has a high yield in one fruiting season in many countries, especially in Asia, and a long history of use as an edible fruit and traditional medicine. A great diversity of nutritive compounds such as fatty acids, amino acids, vitamins, minerals and bioactive compounds, including anthocyanins, rutin, quercetin, chlorogenic acid, and polysaccharides have been found in mulberry fruit depending on the cultivars and maturity stages. Furthermore, the extracts and active components of mulberry fruit have demonstrated numerous biological activities, including anti-oxidant, neuroprotective, anti-atherosclerosis, immunomodulative, anti-tumor, anti-hyperglycemic, hypolipidemic activities in vitro and in vivo studies, and received increasing interest from researchers and pharmaceutical companies...
November 13, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29128856/activation-of-nrf2-pathway-and-inhibition-of-nlrp3-inflammasome-activation-contribute-to-the-protective-effect-of-chlorogenic-acid-on-acute-liver-injury
#8
Ameng Shi, Haitao Shi, Yan Wang, Xin Liu, Yan Cheng, Hong Li, Hongli Zhao, Shuangni Wang, Lei Dong
Chlorogenic acid (CGA), a kind of polyphenol found in coffee, fruits and vegetables, has potent anti-oxidant and anti-inflammatory properties. Our previous studies showed CGA could efficiently alleviate liver fibrosis in rats. However, whether CGA regulates nuclear factor erythroid-2-related factor 2 (Nrf2) anti-oxidant pathway and NLRP3 inflammasome activation and protects against carbon tetrachloride (CCl4)-induced acute liver injury are unknown. We found that CGA could increase Nrf2 activation and expression of Nrf2-related anti-oxidant genes, including HO-1, NQO1 and GCLC...
November 9, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29121975/the-pocket-4-life-project-bioavailability-and-beneficial-properties-of-the-bioactive-compounds-of-espresso-coffee-and-cocoa-based-confectionery-containing-coffee-study-protocol-for-a-randomized-cross-over-trial
#9
Pedro Mena, Michele Tassotti, Daniela Martini, Alice Rosi, Furio Brighenti, Daniele Del Rio
BACKGROUND: Coffee is an important source of bioactive compounds, including caffeine, phenolic compounds (mainly chlorogenic acids), trigonelline, and diterpenes. Several studies have highlighted the preventive effects of coffee consumption on major cardiometabolic diseases, but the impact of coffee dosage on markers of cardiometabolic risk is not well understood. Moreover, the pool of coffee-derived circulating metabolites and the contribution of each metabolite to disease prevention still need to be evaluated in real-life settings...
November 9, 2017: Trials
https://www.readbyqxmd.com/read/29120465/resonance-raman-detection-of-antioxidants-using-an-iron-oxide-nanoparticle-catalysed-decolourisation-assay
#10
Sian Sloan-Dennison, Neil C Shand, Duncan Graham, Karen Faulds
Nanozymes are metal nanoparticles with catalytic properties that can be used to oxidise peroxidase substrates giving a colorimetric response which can be detected using UV-vis, and recently, Raman spectroscopy. Due to their ease of synthesis and increased stability, nanozymes are being increasing investigated to replace conventional enzymes for the detection of biomolecules. Here we exploit the catalytic activity of iron oxide (Fe2O3) nanoparticles combined with the substrate 2,2-azinobis(3-ethyl-benzothiazoline-6-sulfonic acid) (ABTS) in a decolourisation assay for the detection of antioxidants...
November 9, 2017: Analyst
https://www.readbyqxmd.com/read/29120359/simultaneous-determination-of-seven-components-in-rat-plasma-by-the-uplc-ms-ms-method-and-application-of-pharmacokinetic-studies-to-simiaoyong-an-decoction
#11
Yuanyan Liu, Sensen Chi, Weihua Wang, Lei Su, Bin Liu
SimiaoYong'an Decoction (SYD) is a classical traditional Chinese prescription that is used for the treatment of gangrene, heat-clearing, detoxification and pain alleviation. We developed a sensitive ultra-performance liquid chromatography-tandem mass spectrum (UPLC-MS/MS) method for the simultaneous determination of seven major active ingredients of SYD extract (i.e., harpagide, chlorogenic acid, sweroside, loganin, liquiritin, angoroside C and harpagoside) in rat plasma. The preliminary steps in the plasma analysis were the addition of an internal standard such as linarin, followed by protein precipitation with methanol...
November 9, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29117735/antioxidant-and-%C3%AE-glucosidase-inhibitory-ingredients-identified-from-jerusalem-artichoke-flowers
#12
Yan-Ming Wang, Jian-Qiang Zhao, Jun-Li Yang, Pema Tsering Idong, Li-Juan Mei, Yan-Duo Tao, Yan-Ping Shi
Jerusalem artichoke (JA, Helianthus tuberosus L.) has been researched extensively due to its wide range of uses, but there are limited studies on its flowers. In this study, we report the first detailed phytochemical study on JA flowers, which yielded 21 compounds. Compound 4 was identified as a major water-soluble yellow pigment of JA flowers. In addition, the methanol extract of JA flowers and the isolates were evaluated for their antioxidant and α-glucosidase inhibitory activities. Among the tested compounds, compound 13 showed the strongest ABTS(+) free radical scavenging activity with SC50 value of 2...
November 9, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29116355/isolation-and-identification-of-human-metabolites-from-a-novel-anti-tumor-candidate-drug-5-chlorogenic-acid-injection-by-hplc-hrms-ms-n-and-hplc-spe-nmr
#13
Tiankun Ren, Yanan Wang, Caihong Wang, Mengtian Zhang, Wang Huang, Jiandong Jiang, Wenbin Li, Jinlan Zhang
A novel anti-tumor candidate drug, 5-chlorogenic acid (5-CQA) injection, was used for the treatment of malignant glioma in clinical trial (phase I) in China. The isolation and identification of the metabolites of 5-CQA injection in humans were investigated in the present study. Urine and feces samples obtained after intramuscular administration of 5-CQA injection to healthy adults have been analyzed by high-performance liquid chromatography coupled with high-resolution mass and multiple-stage mass spectrometry (HPLC-HRMS/MS(n))...
November 7, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29115619/administration-of-chlorogenic-acid-alleviates-spinal-cord-injury-via-tlr4-nf%C3%A2-%C3%AE%C2%BAb-and-p38-signaling-pathway-anti%C3%A2-inflammatory-activity
#14
Dayong Chen, Dan Pan, Shaolong Tang, Zhihong Tan, Yanan Zhang, Yunfeng Fu, Guohua Lü, Qinghua Huang
Chlorogenic acid, as a secondary metabolite of plants, exhibits a variety of effects including free radical scavenging, antiseptic, anti‑inflammatory and anti‑viral, in addition to its ability to reduce blood glucose, protect the liver and act as an anti‑hyperlipidemic agent and cholagogue. The present study demonstrated that administration of chlorogenic acid alleviated spinal cord injury (SCI) via anti‑inflammatory activity mediated by nuclear factor (NF)‑κB and p38 signaling pathways. Wistar rats were used to structure a SCI model rat to explore the effects of administration of chlorogenic acid on SCI...
November 6, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29111589/effect-of-in-vitro-digestion-on-the-total-antioxidant-capacity-and-phenolic-content-of-3-species-of-oregano-hedeoma-patens-lippia-graveolens-lippia-palmeri
#15
Erick Paul Gutiérrez-Grijalva, Miguel Angel Angulo-Escalante, Josefina León-Félix, J Basilio Heredia
Oregano phenolic compounds have been studied for their anti-inflammatory properties. Nonetheless, after ingestion, the gastrointestinal environment can affect their antioxidant stability and thus their bioactive properties. To evaluate the effect of in vitro gastrointestinal (GI) digestion on the phenolic compounds of 3 species of oregano (Hedeoma patens, Lippia graveolens, and Lippia palmeri), the total reducing capacity, total flavonoid content, and antioxidant capacity were evaluated before and after in vitro GI digestion...
November 7, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29111322/phytochemical-analysis-and-antibacterial-activity-of-gentiana-macrophylla-extract-against-bacteria-isolated-from-burn-wound-infections
#16
Chaohong Yin, Longwei Xie, Yun Guo
The management of burn wound victims is often considered a difficult task due to frequent infections. Moreover, the treatment with conventional antibiotics is associated with the upsurge of drug resistant bacterial strains. Therefore there is pressing need to explore antimicrobials that could overcome these problems. Plant extracts have been used as antimicrobials in different systems of medicine. Gentiana species have been widely used in Chinese system of traditional medicine for the treatment of various ailments including microbial infections...
October 27, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29098829/-difference-of-chemical-constituents-in-eucommiae-cortex-from-different-habitats-by-lc-qtof-ms-ms
#17
Ying Yan, Hui Zhao, Li-Si Zou, Xun-Hong Liu, Chuan Chai, Sheng-Nan Wang, Yu-Jiao Hua
In order to study the influence of ecological environment regarding the synthesis and accumulation of metabolites in Eucommiae Cortex, LC-QTOF MS/MS method combined with multivariate statistical analysis was used to analyze the differences of chemical constituents in Eucommiae Cortex from different habitats. Through the analysis of the multistage tandem mass spectrometry, the characteristic peaks were extracted with mass spectrometry data peak matching, peak alignment, and noise filtering. Principal component analysis (PCA) and partial least-squares discriminant analysis (PLS-DA) were used for data processing...
July 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29098820/-analyze-nanofiltration-separation-rule-of-chlorogenic-acid-from-low-concentration-ethanol-by-donnan-effect-and-solution-diffusion-effect
#18
Cun-Yu Li, Li-Cheng Liu, Li-Yang Jin, Hong-Yang Li, Guo-Ping Peng
To separate chlorogenic acid from low concentration ethanol and explore the influence of Donnan effect and solution-diffusion effect on the nanofiltration separation rule. The experiment showed that solution pH and ethanol volume percent had influences on the separation of chlorogenic acid. Within the pH values from 3 to 7 for chlorogenic acid in 30% ethanol, the rejection rate of chlorogenic acid was changed by 70.27%. Through the response surface method for quadratic regression model, an interaction had been found in molecule weight cut-off, pH and ethanol volume percent...
July 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29096175/regulation-of-chlorogenic-acid-biosynthesis-by-hydroxycinnamoyl-coa-quinate-hydroxycinnamoyl-transferase-in-lonicera-japonica
#19
Jingru Zhang, Minlin Wu, Weidong Li, Genben Bai
For many centuries, Lonicera japonica has been used as an effective herb for the treatment of inflammation and swelling because of the presence of bioactive components such as chlorogenic acid (CGA). To clarify the relationship between L. japonica hydroxycinnamoyl CoA quinate hydroxycinnamoyl transferase (HQT) gene expression and CGA content, an HQT eukaryotic expression system was constructed using Gateway cloning. L. japonica callus transformed with HQT was obtained using Agrobacterium tumefaciens-mediated transformation...
October 21, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29091881/phytochemical-profile-and-mechanisms-involved-in-the-anti-nociception-caused-by-the-hydroethanolic-extract-obtained-from-tocoyena-formosa-cham-schltdl-k-schum-jenipapo-bravo-leaves-in-mice
#20
Francisco Rafael Alves Santana Cesário, Thaís Rodrigues de Albuquerque, Giovana Mendes de Lacerda, Maria Rayane Correia de Oliveira, Lindaiane Bezerra Rodrigues, Anita Oliveira Brito Pereira Bezerra Martins, Aline Augusti Boligon, Lucindo José Quintans Júnior, Adriano Antunes de Souza Araújo, Mariana Lima Vale, Henrique Douglas Melo Coutinho, Irwin Rose Alencar de Menezes
Tocoyena formosa, a small ornamental tree growing in the dry regions of central Brazil, is commonly known as 'genipapo do bravo'. This is a medicinal plant traditionally used as an analgesic for rheumatic pain, lower back pain and myalgia, however its use is carried out without scientific evidence, which thus justifies the development of studies to investigate and prove its therapeutic potential. Therefore, the objective of this study was to evaluate the phytochemical profile of Tocoyena formosa (Cham. & Schlecht...
October 26, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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