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chlorogenic acid

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https://www.readbyqxmd.com/read/28935146/effect-of-chocolate-and-mate-tea-on-the-lipid-profile-of-individuals-with-hiv-aids-on-antiretroviral-therapy-a-clinical-trial
#1
Suelen J Souza, Aline A Petrilli, Andrea M Teixeira, Patricia M Pontilho, Antonio A Carioca, Liania A Luzia, José M Souza, Nágila R Damasceno, Aluisio A Segurado, Patricia H Rondó
OBJECTIVE: HIV/AIDS is generally associated with dyslipidemia and oxidative imbalance, which are caused by the infection itself and by antiretroviral therapy (ART). The flavonoids, found in cocoa and yerba mate, have antioxidant and hypolipidemic properties. The aim of this study was to evaluate the effects of the consumption of dark chocolate and mate tea on the lipid profiles of individuals with HIV/AIDS who are undergoing ART. METHODS: A randomized, double-blind, placebo-controlled crossover clinical trial was conducted with 92 patients receiving ART for ≥6 mo and with viral suppression...
November 2017: Nutrition
https://www.readbyqxmd.com/read/28929684/-study-on-uhplc-fingerprint-and-determination-of-eight-phenolic-components-of-tetrastigma-hemsleyanum-leaves
#2
Shi-Ming Fan, Hui-Long Xu, Xin-Yue Xie, Bi-Ya Cai, Fu-Xian Zou, Wen Xu, Zhi-Sen Xie, Xin-Ping Huang
A novel method combining ultra-high performance liquid chromatography (UHPLC) fingerprint and simultaneous quantitative analysis of eight phenolic components was developed and validated for quality evaluation of Tetrastigma hemsleyanum leaves. For fingerprint analysis, 15 peaks were selected as the common peaks to evaluate the similarities among 41 batches of T. hemsleyanum leaves collected from different regions. Additionally, simultaneous quantification of eight markers, including neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, isoorientin, orientin, vitexin-2-O-rhamnoside,vitexin and isovitexin, was performed and the obtained data demonstrated that our method has achieved desired linearity, precision and accuracy...
November 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28929588/bioactive-compounds-of-shuang-huang-lian-prescription-and-an-insight-into-its-binding-mechanism-by-%C3%AE-2-adrenoceptor-chromatography-coupled-with-site-directed-molecular-docking
#3
Jing Wang, Fengwu Li, Kaizhu Zeng, Qian Li, Xinfeng Zhao, Xiaohui Zheng
Owing to the promising clinical efficacy and relatively simple composition, Shuang-Huang-Lian prescription is widely prescribed for the treatment of acute upper respiratory tract infection and acute bronchitis in practice. This necessitates the understanding of the bioactive compounds of the prescription and their binding mechanism to β2-adrenoceptor, which mediates the aforementioned ailments. In this work, a column containing immobilized β2-adrenoceptor was prepared using a diazonium salt reaction. The bioactive compound collected from the β2-adrenoceptor column was identified as chlorogenic acid by using high-performance liquid chromatography coupled with ion trap mass spectrometry...
September 20, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28928534/suitability-of-the-probiotic-lactic-acid-bacteria-strains-as-the-starter-cultures-in-unripe-cornelian-cherry-cornus-mas-l-fermentation
#4
Agata Czyżowska, Alicja Z Kucharska, Agnieszka Nowak, Anna Sokół-Łętowska, Ilona Motyl, Narcyz Piórecki
This study examines the influence of lactic acid fermentation on iridoid and polyphenolic compounds in unripe Cornus mas L. fruits. Fermentation was carried out at room temperature over 6 weeks. Eight versions of the fermentation process were conducted: with inoculation by microflora isolated from black olives, Lb. brevis 18 M, Lb. casei 0919, Lb. paracasei 920, Lb. rhamnosus 0900, Lb. rhamnosus 0908, and spontaneous fermentation with and without summer savory (Satureja hortensis). The polyphenolic compounds, iridoids and antioxidant activities were examined in the products obtained...
August 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28926862/comparison-of-the-morphology-anatomy-and-chemical-profile-of-mikania-glomerata-and-mikania-laevigata
#5
Vanessa Cruz de Oliveira Costa, Alexandre Augusto Borghi, Juliana Lischka Sampaio Mayer, Alexandra Christine Helena Frankland Sawaya
Mikania glomerata and Mikania laevigata are medicinal plants popularly used in Brazil for colds and asthma. Although several studies report differences in their composition, they are frequently used indistinctly, which may be due to misidentification of the species or the plant part used. Herein, the chemical, anatomical, and morphological profiles of both species were evaluated, seeking to differentiate them. Due to the pattern of secondary metabolites found in M. glomerata and M. laevigata, the chemical profile of the leaves was the characteristic that best differentiated the two species...
September 19, 2017: Planta Medica
https://www.readbyqxmd.com/read/28925149/-research-on-modeling-method-to-analyze-lonicerae-japonicae-flos-extraction-process-with-online-mems-nir-based-on-two-types-of-error-detection-theory
#6
Chen-Zhao Du, Zhi-Sheng Wu, Na Zhao, Zheng Zhou, Xin-Yuan Shi, Yan-Jiang Qiao
To establish a rapid quantitative analysis method for online monitoring of chlorogenic acid in aqueous solution of Lonicera Japonica Flos extraction by using micro-electromechanical near infrared spectroscopy (MEMS-NIR). High performance liquid chromatography(HPLC) was used as reference method.Kennard-Stone (K-S) algorithm was used to divide sample sets, and partial least square(PLS) regression was adopted to establish the multivariate analysis model between the HPLC analysis contents and NIR spectra. The synergy interval partial least squares (SiPLS) was used to selected modeling waveband to establish PLS models...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28924501/identification-and-analysis-of-cyp450-genes-from-transcriptome-of-lonicera-japonica-and-expression-analysis-of-chlorogenic-acid-biosynthesis-related-cyp450s
#7
Xiwu Qi, Xu Yu, Daohua Xu, Hailing Fang, Ke Dong, Weilin Li, Chengyuan Liang
BACKGROUND: Lonicera japonica is an important medicinal plant that has been widely used in traditional Chinese medicine for thousands of years. The pharmacological activities of L. japonica are mainly due to its rich natural active ingredients, most of which are secondary metabolites. CYP450s are a large, complex, and widespread superfamily of proteins that participate in many endogenous and exogenous metabolic reactions, especially secondary metabolism. Here, we identified CYP450s in L...
2017: PeerJ
https://www.readbyqxmd.com/read/28924162/insights-into-the-functionality-of-endophytic-actinobacteria-with-a-focus-on-their-biosynthetic-potential-and-secondary-metabolites-production
#8
Ajit Kumar Passari, Vineet Kumar Mishra, Garima Singh, Pratibha Singh, Brijesh Kumar, Vijai Kumar Gupta, Rupak Kumar Sharma, Ratul Saikia, Anthonia O' Donovan, Bhim Pratap Singh
Endophytic actinobacteria play an important role in growth promotion and development of host plant by producing enormous quantities of novel bioactive natural products. In the present investigation, 169 endophytic actinobacteria were isolated from endospheric tissues of Rhynchotoechum ellipticum. Based on their antimicrobial potential, 81 strains were identified by 16rRNA gene analysis, which were taxonomically grouped into 15 genera. All identified strains were screened for their plant growth promoting attributes and, for the presence of modular polyketide synthases (PKSI, PKSII and nonribosomal peptide synthetase (NRPS) gene clusters to correlate the biosynthetic genes with their functional properties...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28919396/protective-effect-of-chlorogenic-acid-on-the-inflammatory-damage-of-pancreas-and-lung-in-mice-with-l-arginine-induced-pancreatitis
#9
Tatsuya Ohkawara, Hiroshi Takeda, Jun Nishihira
AIMS: Pancreatitis is characterized by inflammatory disease with severe tissue injury in pancreas, and the incidence of pancreatitis has been recently increasing. Although several treatments of acute pancreatitis have been developed, some patients have been resistant to current therapy. Chlorogenic acid (CGA) is one of the polyphenols, and is known to have an anti-inflammatory effect. In this study, we investigated the effects of CGA on experimental pancreatitis in mice. MATERIALS AND METHODS: Pancreatitis was induced by twice injection of l-arginine (5g/kg body weight)...
September 14, 2017: Life Sciences
https://www.readbyqxmd.com/read/28918319/determination-of-chlorogenic-acids-and-caffeine-in-homemade-brewed-coffee-prepared-under-various-conditions
#10
Jong-Sup Jeon, Han-Taek Kim, Il-Hyung Jeong, Se-Ra Hong, Moon-Seog Oh, Kwang-Hee Park, Jae-Han Shim, A M Abd El-Aty
Coffee, a complex mixture of more than 800 volatile compounds, is one of the most valuable commodity in the world, whereas caffeine and chlorogenic acids (CGAs) are the most common compounds. CGAs are mainly composed of caffeoylquinic acids (CQAs), dicaffeoylquinic acids (diCQAs), and feruloylquinic acids (FQAs). The major CGAs in coffee are neochlorogenic acid (3-CQA), cryptochlorogenic acid (4-CQA), and chlorogenic acid (5-CQA). Many studies have shown that it is possible to separate the isomers of FQAs by high-performance liquid chromatography (HPLC)...
August 31, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28918124/polyphenols-reported-to-shift-apap-induced-changes-in-mapk-signaling-and-toxicity-outcomes
#11
REVIEW
Ngoc Uy Nguyen, Brendan David Stamper
Due to its widespread availability, acetaminophen (APAP) is the leading cause for drug-induced liver injury in many countries including United States and United Kingdom. When used as recommended, APAP is relatively safe. However, in overdose cases, increased metabolism of APAP to N-acetyl-para-benzoquinoneimine (NAPQI), a reactive metabolite, leads to glutathione (GSH) depletion, oxidative stress, and cellular injury. Throughout this process, a variety of factors play important roles in propagating toxicity, including c-Jun N-terminal kinase (JNK), a member of the mitogen-activated protein kinase (MAPK) family...
September 13, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28911547/multifunctions-of-dietary-polyphenols-in-the-regulation-of-intestinal-inflammation
#12
REVIEW
Makoto Shimizu
Food for specified health use is a type of functional food approved by the Japanese government, with more than 1250 products in 10 health-claim categories being approved as of April 2016. Polyphenols are currently used as functional ingredients in seven of the 10 categories. Although they have not yet been used for the food-for-specified-health-use category of "gut health promotion," polyphenols are expected to contribute to the future development of gut-modulating food. Intestinal functions include digestion/absorption, acting as a barrier, recognition of external factors, and signal transduction...
January 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28906554/changes-in-phytochemical-composition-bioactivity-and-in-vitro-digestibility-of-guayusa-leaves-ilex-guayusa-loes-in-different-ripening-stages
#13
José Villacís-Chiriboga, Almudena García-Ruiz, Nieves Baenas, Diego A Moreno, Antonio J Meléndez-Martínez, Carla M Stinco, Lourdes Jerves-Andrade, Fabián León-Tamariz, Johanna Ortiz-Ulloa, Jenny Ruales
BACKGROUND: Guayusa (Ilex guayusa Loes.) leaves, native of the Ecuadorian amazon, are popularly used for preparing teas. This study aimed to assess the influence of leaf age on the phenolic compounds and carotenoids, and the bioactivity and digestibility (in vitro) of aqueous and hydroalcoholic leaf extracts. RESULTS: In total, 14 phenolic compounds were identified and quantified. Chlorogenic acid and quercetin-3-O-hexose were the main representatives of the hydroxycinnamic acids and flavonols, respectively...
September 14, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28901801/screening-of-some-biological-activities-of-alyssum-fulvescens-var-fulvescens-known-as-ege-madwort
#14
Cennet Ozay, Ramazan Mammadov
In this research, the phenolic composition, antioxidant, antibacterial and cytotoxic activities of the methanolic extracts obtained from Alyssum fulvescens var. fulvescens aerial parts known as Ege kuduzotu in western Turkey, were firstly investigated. The antioxidant activity of the extract was determined by DPPH, metal chelating, phosphomolybdenum, β-carotene/linoleic acid and ferric reducing power assays. Moreover, total phenolic and flavonoid contents in the extract were investigated. The brine shrimp (Artemia salina L...
September 2017: Acta Biologica Hungarica
https://www.readbyqxmd.com/read/28899482/enzymatic-synthesis-of-chlorogenic-acid-glucoside-using-dextransucrase-and-its-physical-and-functional-properties
#15
Seung-Hee Nam, Jin-A Ko, Woojin Jun, Young-Jung Wee, Marie K Walsh, Kwang-Yeol Yang, Jin-Ho Choi, Jon-Bang Eun, Jeong Choi, Young-Min Kim, Songhee Han, Thi Thanh Hanh Nguyen, Doman Kim
Chlorogenic acid, a major polyphenol in edible plants, possesses strong antioxidant activity, anti-lipid peroxidation and anticancer effects. It used for industrial applications; however, this is limited by its instability to heat or light. In this study, we for the first time synthesized chlorogenic acid glucoside (CHG) via transglycosylation using dextransucrase from Leuconostoc mesenteroides and sucrose. CHG was purified and its structure determined by nuclear magnetic resonance and matrix-associated laser desorption ionization-time-of-flight mass spectroscopy...
December 2017: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/28898412/antioxidant-activity-of-chinese-shanxi-aged-vinegar-and-its-correlation-with-polyphenols-and-flavonoids-during-the-brewing-process
#16
Xiaolin Xie, Yu Zheng, Xian Liu, Cheng Cheng, Xianglong Zhang, Ting Xia, Songfeng Yu, Min Wang
One of the most famous Chinese vinegars, Shanxi aged vinegar (SAV), is produced with solid-state fermentation technology. Total antioxidant activity (TAC) is a special property for SAV. In this study, we investigate correlations between total antioxidant activity (TAC) and total polyphenol (TP) and total flavonoid (TF) contents of SAV, especially during the brewing process. For SAV, TAC, TP, and TF increased with the increase of aging time. The correlation coefficients between TAC and TP were 0.869 and 0.934, respectively, when analyzed with the method of ABTS and FRAP...
September 12, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28892660/phytotoxic-triterpene-saponins-from-bellis-longifolia-an-endemic-plant-of-crete
#17
Maria I Stavropoulou, Apostolis Angelis, Nektarios Aligiannis, Eleftherios Kalpoutzakis, Sofia Mitakou, Stephen O Duke, Nikolas Fokialakis
In a study of 62 plant species of the Cretan flora for their phytotoxic activity, plants were extracted successively with CH2Cl2, MeOH and H2O. Phytotoxicity evaluation of the 240 extracts was performed against Lactuca sativa L. and Agrostis stolonifera L.. The MeOH extract of Bellis longifolia was the most phytotoxic. Bioassay-guided fractionation revealed that a fraction consisting mainly of saponins was the most effective. Separation of the saponins was performed using initially a step-gradient Centrifugal Partition Chromatography (CPC)...
September 7, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28888448/effect-of-explosion-puffed-coffee-on-locomotor-activity-and-behavioral-patterns-in-drosophila-melanogaster
#18
Bong Soo Ko, So Hyun Ahn, Dong Ouk Noh, Ki-Bae Hong, Sung Hee Han, Hyung Joo Suh
We hypothesized that the administration of explosion-puffed coffee, containing γ-aminobutyric acid (GABA) and 5-hydroxytryptophan (5-HTP), would be associated with a reduction of the caffeine effect on sleep behavior and behavioral patterns, which was investigated in a Drosophila model. The effects of feeding roasted coffee beans (RB), explosion-puffed coffee beans puffed at 0.75MPa and 0.9MPa (PB 7.5 and PB 9.0, respectively), or decaffeinated coffee beans (DeRB) on locomotor activity and behavioral patterns of Drosophila was analyzed...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28888145/nmr-based-identification-of-the-major-bioactive-molecules-from-an-italian-cultivar-of-lycium-barbarum
#19
Annalisa Lopatriello, Rosario Previtera, Simona Pace, Markus Werner, Luigi Rubino, Oliver Werz, Orazio Taglialatela-Scafati, Martino Forino
Lycium barbarum (Solanaceae), long known to the traditional Chinese medicine because of its many health-promoting effects, has of late spread widely across the Western hemisphere, mainly on account of the nutritional richness in vitamins, minerals and antioxidant metabolites of its fruits. Data on bioactive metabolites from fruits and leaves, which are commonly consumed in soups and salads, are scarce and sometimes even contradictory. By means of NMR, the present study identified the specialised products contained in an Italian cultivar of L...
September 6, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28887907/characterization-of-wild-blueberry-polyphenols-bioavailability-and-kinetic-profile-in-plasma-over-24-hour-period-in-human-subjects
#20
Siqiong Zhong, Amandeep Sandhu, Indika Edirisinghe, Britt Burton-Freeman
SCOPE: Understanding the metabolic fate of polyphenols from plant foods can aid in developing dietary recommendations that maximize their health benefits. Wild blueberries (WBB) provide a distinctive composition of dietary anthocyanins and chlorogenic acid (CGA). METHODS AND RESULTS: This is a single blind, randomized, two-arm crossover controlled study. Human subjects ingested a WBB beverage (25 g freeze dried WBB powder) or placebo beverage with a meal and plasma was collected over 24 h...
September 9, 2017: Molecular Nutrition & Food Research
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