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chlorogenic acid

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https://www.readbyqxmd.com/read/27910755/comparison-of-the-composition-and-antioxidant-activities-of-phenolics-from-the-fruiting-bodies-of-cultivated-asian-culinary-medicinal-mushrooms
#1
Shaoling Lin, Lai Tsz Ching, Xinxin Ke, Peter Chi Keung Cheung
The composition profile and the antioxidant properties of phenolics in water extracts obtained from the fresh fruiting bodies of 4 common cultivated Asian edible mushrooms-Agrocybe aegerita, Pleurotus ostreatus, P. eryngii, and Pholiota nameko were compared. The water extract from A. aegerita (AaE) had the highest total phenolic content (TPC) at 54.18 ± 0.27 gallic acid equivalents (μmol/L)/mg extract (P < 0.05), as measured by the Folin-Ciocalteu method, and consisted of the largest number (including gallic acid, protocatechuic acid, chlorogenic acid, ferulic acid, and sinapic acid) and total amounts of phenolic acids identified by Fourier transform-ion cyclotron resonance mass spectrometry...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27908708/chlorogenic-acid-ameliorates-isoproterenol-induced-myocardial-injury-in-rats-by-stabilizing-mitochondrial-and-lysosomal-enzymes
#2
Palaniyandi Akila, Lourthurani Asaikumar, Lakshmanan Vennila
This study was deliberated to aspire the effects of chlorogenic acid (CGA) against myocardial infarction (MI) induced by Isoproterenol (ISO), in a rat model. In the pathology of MI, enzymes released due to the mitochondrial and lysosomal lipid peroxidation play an integral role. Induction of rats with ISO (85mg/kg BW) for 2 consecutive days resulted in a significant decrease in the activities of heart mitochondrial enzymes isocitrate dehydrogenase (ICDH), α-ketoglutarate dehydrogenase (α-KGDH), succinate dehydrogenase (SDH) and malate dehydrogenase (MDH)...
November 28, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27907185/antioxidant-antimicrobial-and-cytotoxic-properties-as-well-as-the-phenolic-content-of-the-extract-from-hancornia-speciosa-gomes
#3
Uilson P Santos, Jaqueline F Campos, Heron Fernandes V Torquato, Edgar Julian Paredes-Gamero, Carlos Alexandre Carollo, Leticia M Estevinho, Kely de Picoli Souza, Edson Lucas Dos Santos
Hancornia speciosa Gomes (Apocynaceae) is a fruit tree, popularly known as mangabeira, and it is widely distributed throughout Brazil. Several parts of the plant are used in folk medicine, and the leaf and bark extracts have anti-inflammatory, antihypertensive, antidiabetic, and antimicrobial properties. In this study, we investigated the chemical composition of the ethanolic extract of Hancornia speciosa leaves (EEHS) and its antioxidant, antimicrobial, and cytotoxic activities as well as the mechanisms involved in cell death...
2016: PloS One
https://www.readbyqxmd.com/read/27903226/protective-effects-of-caffeic-acid-and-the-alzheimer-s-brain-an-update
#4
Solomon Habtemariam
Caffeic acid (CA) and related phenylpropanoic acids are ubiquitous natural products of the shikimic acid pathway origin. Due to the presence of diorthohydroxyl aromatic (catecholic) moiety, CA is not only one of the most potent antioxidant phenyl propanoids but also display numerous other pharmacological effects ranging from antiinflammatory to anticancer effects. Recent studies also demonstrated that CA both in its free form or conjugated with other groups such as quinic acid and sugars display profound effects in the brain including protection from toxicity induced by a variety of agents and/or experimental models of Alzheimer's disease (AD)...
November 29, 2016: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/27891094/anti-acne-activity-of-italian-medicinal-plants-used-for-skin-infection
#5
Kate Nelson, James T Lyles, Tracy Li, Alessandro Saitta, Eugenia Addie-Noye, Paula Tyler, Cassandra L Quave
Propionibacterium acnes is implicated in the pathogenesis of acne vulgaris, which impacts >85% of teenagers. Novel therapies are in high demand and an ethnopharmacological approach to discovering new plant sources of anti-acne therapeutics could contribute to filling this void in effective therapies. The aims of our study were two-fold: (1) To determine if species identified in ethnopharmacological field studies as having traditional uses for skin and soft tissue infection (SSTI) exhibit significantly more activity against P...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27886116/simultaneous-ultra-performance-liquid-chromatography-determination-and-antioxidant-activity-of-linarin-luteolin-chlorogenic-acid-and-apigenin-in-different-parts-of-compositae-species
#6
Seung Hwan Hwang, Ji Hun Paek, Soon Sung Lim
Linarin (LA), luteolin (LE), chlorogenic acid (CA) and apigenin (AP) are four major flavonoids with various promising bioactivities found in Compositae (COP) species. A reliable, reproducible and accurate method for the simultaneous and quantitative determination of these four major flavonoids by Ultra Performance Liquid Chromatography (UPLC) analysis was developed. This method should be appropriate for the quality assurance of COP. The UPLC separation was carried out using an octadecylsilane (ODS) Hypersil (2...
November 23, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27883009/bumble-bee-parasite-strains-vary-in-resistance-to-phytochemicals
#7
Evan C Palmer-Young, Ben M Sadd, Philip C Stevenson, Rebecca E Irwin, Lynn S Adler
Nectar and pollen contain diverse phytochemicals that can reduce disease in pollinators. However, prior studies showed variable effects of nectar chemicals on infection, which could reflect variable phytochemical resistance among parasite strains. Inter-strain variation in resistance could influence evolutionary interactions between plants, pollinators, and pollinator disease, but testing direct effects of phytochemicals on parasites requires elimination of variation between bees. Using cell cultures of the bumble bee parasite Crithidia bombi, we determined (1) growth-inhibiting effects of nine floral phytochemicals and (2) variation in phytochemical resistance among four parasite strains...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27873069/estimated-dietary-intake-and-major-food-sources-of-polyphenols-in-elderly-of-vi%C3%A3-osa-brazil-a-population-based-study
#8
Mary Anne Nascimento-Souza, Pedro Gontijo de Paiva, Jara Pérez-Jiménez, Sylvia do Carmo Castro Franceschini, Andréia Queiroz Ribeiro
PURPOSE: Epidemiological studies have remarked the beneficial role that polyphenols may have in the elderly population such as cancer and cardiovascular disease prevention. This is particularly relevant considering the global tendency of population aging. Data on polyphenol intake in the elderly population are scarce and usually provide partial information-only for some polyphenol classes. The aim of this study was to estimate the intake of polyphenols and its major dietary contributors in the population of Viçosa...
November 21, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/27872708/anti-hyperglycaemic-and-antioxidant-effects-of-bidens-tripartita-and-quantitative-analysis-on-its-active-principles
#9
Nilüfer Orhan, Ülkü Gökçen İçöz, Levent Altun, Mustafa Aslan
OBJECTIVES: Bidens species are used for their antidiabetic properties traditionally in many countries. Aim of this study is to evaluate hypoglycaemic and antidiabetic activity of Bidens tripartita extract and to identify its active compounds through bioactivity guided isolation technique. MATERIALS AND METHODS: Hypoglycaemic effects of B. tripartita extract and its sub-extracts were investigated in normal and glucose-hyperglycaemic rats. Streptozotocin induced diabetic rats were used to examine antidiabetic activity of the extract and its sub-extracts after acute and sub-acute administration...
October 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27872076/anti-schistosomiasis-liver-fibrosis-effects-of-chlorogenic-acid-through-il-13-mir-21-smad7-signaling-interactions-in-vivo-and-in-vitro
#10
Yao Wang, Fan Yang, Jun Xue, Xuan Zhou, Lei Luo, Qian Ma, Yun-Fei Chen, Juan Zhang, Shu-Ling Zhang, Lei Zhao
This study is to investigate the anti-Schistosomiasis liver fibrosis effects of chlorogenic acid (CGA) on IL-13/miR-21/Smad7 signaling interactions in hepatic stellate LX2 cell line and Schistosome-infected mice. The transfection was based on the GV273-miR-21-EGFP and GV369-miR-21-EGFP lentiviral system to up- or down-regulate miR-21 gene in LX2 cells. The mRNA expression of miR-21, Smad7 and connective tissue growth factor (CTGF) and protein expression of Smad7, CTGF, Smad1, p-Smad1, Smad2, p-Smad2, Smad2/3, p-Smad2/3, TGF-β receptor I and α-SMA were assayed...
November 21, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27871334/exploiting-members-of-the-bahd-acyltransferase-family-to-synthesize-multiple-hydroxycinnamate-and-benzoate-conjugates-in-yeast
#11
Aymerick Eudes, Maxence Mouille, David S Robinson, Veronica T Benites, George Wang, Lucien Roux, Yi-Lin Tsai, Edward E K Baidoo, Tsan-Yu Chiu, Joshua L Heazlewood, Henrik V Scheller, Aindrila Mukhopadhyay, Jay D Keasling, Samuel Deutsch, Dominique Loqué
BACKGROUND: BAHD acyltransferases, named after the first four biochemically characterized enzymes of the group, are plant-specific enzymes that catalyze the transfer of coenzyme A-activated donors onto various acceptor molecules. They are responsible for the synthesis in plants of a myriad of secondary metabolites, some of which are beneficial for humans either as therapeutics or as specialty chemicals such as flavors and fragrances. The production of pharmaceutical, nutraceutical and commodity chemicals using engineered microbes is an alternative, green route to energy-intensive chemical syntheses that consume petroleum-based precursors...
November 21, 2016: Microbial Cell Factories
https://www.readbyqxmd.com/read/27865352/plum-polyphenols-inhibit-colorectal-aberrant-crypt-foci-formation-in-rats-potential-role-of-the-mir-143-protein-kinase-b-mammalian-target-of-rapamycin-axis
#12
Nivedita Banerjee, Hyemee Kim, Stephen T Talcott, Nancy D Turner, David H Byrne, Susanne U Mertens-Talcott
The nutritional prevention of aberrant crypt foci by polyphenols may be a crucial step to dietary cancer prevention. The objective of this study was to determine the underlying mechanisms that contribute to the anti-inflammatory and antitumorigenic properties of plum (Prunus salicina L.) polyphenols, including chlorogenic acid and neochlorogenic acid, in azoxymethane (AOM)-treated rats. The hypothesis was that plum polyphenolics suppress AOM-induced aberrant crypt foci formation through alterations in the protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway and relative micro-RNA expressions...
October 2016: Nutrition Research
https://www.readbyqxmd.com/read/27864112/polar-extracts-from-the-berry-like-fruits-of-hypericum-androsaemum-l-as-a-promising-ingredient-in-skin-care-formulations
#13
Fabiana Antognoni, Mariacaterina Lianza, Ferruccio Poli, Michela Buccioni, Claudia Santinelli, Giovanni Caprioli, Romilde Iannarelli, Giulio Lupidi, Elisabetta Damiani, Daniela Beghelli, Alessia Alunno, Filippo Maggi
ETHNOPHARMACOLOGICAL RELEVANCE: The top flowering aerial parts of the Hypericum species are traditionally used to prepare ointments to heal cuts and burns. Sometimes even the fruits are used for these purposes. Hypericum androsaemum L., commonly known as tutsan or shrubby St. John's Wort, is a Mediterranean medicinal plant which has been traditionally used to prepare an ointment for treating cuts and wounds. AIM OF THE STUDY: To evaluate the extracts obtained from H...
November 15, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27862988/isolation-purification-and-identification-of-the-main-phenolic-compounds-from-leaves-of-celery-apium-graveolens-l-var-dulce-mill-pers
#14
Guoyan Liu, Linwu Zhuang, Dandan Song, Chunliang Lu, Xin Xu
We developed a simple and meaningful preparative method for the separation and purification of the main phenolic compounds from the leaves of celery (Apium graveolens L. var. dulce Mill./Pers.), as well as established an accurate and specific analytical method for the identification of the main phenolic compounds from celery leaves. The crude extract from celery leaves was prefractioned by polyamide resin to enrich the phenolic compounds. They were then purified further by preparative high-performance liquid chromatography, and seven main phenolic compounds were obtained: including chlorogenic acid, luteolin 7-O-β-d-apiofuranosyl(1→2)-β-d-glucopyranoside, luteolin 7-O-β-d-glucopyranoside, apiin, chrysoeriol 7-O-β-d-apiofuranosyl(1→2)-β-d-glucopyranoside, luteolin 7-O-[β-d-apiofuranosyl(1→2)-(6''-O-malonyl)]-β-d-glucopyranoside, and apigenin 7-O-[β-d-apiofuranosyl(1→2)-(6''-O-malonyl)]-β-d-glucopyranoside...
November 8, 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27861533/chlorogenic-acid-combined-with-lactobacillus-plantarum-2142-reduced-lps-induced-intestinal-inflammation-and-oxidative-stress-in-ipec-j2-cells
#15
Orsolya Palócz, Erzsébet Pászti-Gere, Péter Gálfi, Orsolya Farkas
This study was carried out to investigate protective effect of chlorogenic acid against lipopolysaccharide-induced inflammation and oxidative stress in intestinal epithelial cells. As a marker of inflammatory response, IL-6, IL-8, TNF-α mRNA and protein levels, furthermore, COX-2 mRNA level were followed up. Intracellular redox status and extracellular H2O2 level were also monitored by two fluorescent assays (DCFH-DA, Amplex Red). Moreover, the effect of gut microbiota metabolites in the above mentioned processes was taken into account in our model using Lactobacillus plantarum 2142 bacterial strain...
2016: PloS One
https://www.readbyqxmd.com/read/27859484/gram-microorganisms-dna-polymerase-inhibition-antibacterial-and-chemical-properties-of-fruit-and-leaf-extracts-of-sorbus-acuparia-and-sorbus-caucasica-var-yaltirikii
#16
Halbay Turumtay, Ahmet Midilli, Emine Akyuz Turumtay, Adem Demir, Emine Kılıçkaya Selvi, Emine Esra Budak, Havva Er, Fatih Kocaimamoglu, Hüseyin Baykal, Ali Osman Belduz, Vagif Atamov, Cemal Sandallı
Investigation of novel plant-based agents might provide alternative antibiotics and thus fight antibiotic resistance. Here, we measured the ability of fruit and leaf extracts of Sorbus aucuparia (Sauc) and endemic Sorbus caucasica var. yaltirikii (Scau) to inhibit non-replicative (Klenow Fragment-KF and Bacillus Large Fragment-BLF) and replicative (DnaE and PolC) bacterial DNA polymerases along with their antimicrobial, DPPH free radical scavenging activity (RSA), and chemical contents by total phenolic content (TPC) and HPLC-DAD analysis...
November 17, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/27859283/impact-of-pecan-nut-shell-aqueous-extract-on-the-oxidative-properties-of-margarines-during-storage
#17
Paula Cristina Engler Ribeiro, Priscila de Britto Policarpi, Andrea Dal Bo, Pedro Alberto Barbetta, Jane Mara Block
BACKGROUND: The oxidative properties of margarines supplemented with pecan nut shell extracts, rosemary extract and butylated hydroxytoluene (BHT) were investigated RESULTS: The extracts of pecan nut shell and rosemary showed a high content of total phenolics and condensed tannins (93 and 102.9 mg GAE g(-1) and 46 and 38.9 mg CE g(-1) , respectively) as well as a high antioxidant activity (1257 and 2306 µmol TEAC g(-1) , and 293 and 856 mg TEAC g(-1) for ABTS and DPPH methods, respectively)...
November 17, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27856271/antimicrobial-antitrypanosomal-and-antibiofilm-activity-of-equisetum-hyemale
#18
Camilla Filippi Dos Santos Alves, Pauline Cordenonsi Bonez, Marcia de Ebling de Souza, Ritiel Corrêa da Cruz, Aline Augusti Boligon, Mariana Piana, Thiele Facim Brum, Grazielle Guidolin Rossi, Roberta da Silva Jesus, Thirssa Helena Grando, Silvia Gonzalez Monteiro, Marli Matiko Anraku de Campos, Janice Luering Giongo, Roberto Christ Vianna Santos
This study evaluates, for the first time, the antibiofilm, antimicrobial and antiparasitic potential of crude extract and fractions of stems of Equisetum hyemale against several infectious agents (bacteria, fungi, Mycobacterium and Trypanosomes) by broth microdilution technique and investigates the phenolic composition of the plant by high performance liquid chromatography. The crude extract and fractions showed antimicrobial activity, as they were capable of inhibiting the growth of bacteria in minimal inhibitory concentrations (MICs) ranging from 52...
November 14, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27855956/selected-secondary-metabolites-in-echium-vulgare-l-populations-from-nonmetalliferous-and-metalliferous-areas
#19
Sławomir Dresler, Ewelina Rutkowska, Wiesław Bednarek, Grzegorz Stanisławski, Tomasz Kubrak, Anna Bogucka-Kocka, Małgorzata Wójcik
The aim of this study was to evaluate the effect of severe environmental conditions prevailing on metalliferous waste heaps and heavy metal-contaminated growth substrates on accumulation of selected secondary metabolites, antioxidant capacity, and heavy metal concentration in two metallicolous (MC, MZ) and one nonmetallicolous (NM) populations of Echium vulgare L. The shoots and the roots of the three studied populations were collected from their natural habitats. Additionally, the plants were cultivated on different growth substrates, i...
November 14, 2016: Phytochemistry
https://www.readbyqxmd.com/read/27855931/qualitative-properties-of-roasting-defect-beans-and-development-of-its-classification-methods-by-hyperspectral-imaging-technology
#20
Jeong-Seok Cho, Hyung-Jin Bae, Byoung-Kwan Cho, Kwang-Deog Moon
Qualitative properties of roasting defect coffee beans and their classification methods were studied using hyperspectral imaging (HSI). The roasting defect beans were divided into 5 groups: medium roasting (Cont), under developed (RD-1), over roasting (RD-2), interior under developed (RD-3), and interior scorching (RD-4). The following qualitative properties were assayed: browning index (BI), moisture content (MC), chlorogenic acid (CA), trigonelline (TG), and caffeine (CF) content. Their HSI spectra (1000-1700nm) were also analysed to develop the classification methods of roasting defect beans...
April 1, 2017: Food Chemistry
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