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Chemoradiation head and neck cancer

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https://www.readbyqxmd.com/read/29164301/changes-in-multimodality-functional-imaging-parameters-early-during-chemoradiation-predict-treatment-response-in-patients-with-locally-advanced-head-and-neck-cancer
#1
Kee H Wong, Rafal Panek, Alex Dunlop, Dualta Mcquaid, Angela Riddell, Liam C Welsh, Iain Murray, Dow-Mu Koh, Martin O Leach, Shreerang A Bhide, Christopher M Nutting, Wim J Oyen, Kevin J Harrington, Kate L Newbold
OBJECTIVE: To assess the optimal timing and predictive value of early intra-treatment changes in multimodality functional and molecular imaging (FMI) parameters as biomarkers for clinical remission in patients receiving chemoradiation for head and neck squamous cell carcinoma (HNSCC). METHODS: Thirty-five patients with stage III-IVb (AJCC 7th edition) HNSCC prospectively underwent (18)F-FDG-PET/CT, and diffusion-weighted (DW), dynamic contrast-enhanced (DCE) and susceptibility-weighted MRI at baseline, week 1 and week 2 of chemoradiation...
November 21, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29113454/modulators-of-redox-metabolism-in-head-and-neck-cancer
#2
Xiaofei Chen, Jade Mims, Xiumei Huang, Naveen Singh, Edward A Motea, Sarah M Planchon, Muhammad Beg, Allen W Tsang, Mercedes Porosnicu, Melissa L Kemp, David A Boothman, Cristina Furdui
SIGNIFICANCE: Head and Neck Squamous Cell Cancer (HNSCC) is a complex disease characterized by high genetic and metabolic heterogeneity. Radiation therapy (RT) alone or combined with systemic chemotherapy is widely used for treatment of HNSCC as definitive treatment or as adjuvant treatment after surgery. Antibodies against Epidermal Growth Factor Receptor (EGFR) are used in definitive or palliative treatment. Recent Advances. Emerging targeted therapies against other proteins of interest as well as programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1) immunotherapies are being explored in clinical trials...
November 7, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29105549/value-of-extranodal-extension-detected-by-computed-tomography-for-predicting-clinical-response-after-chemoradiotherapy-in-head-and-neck-squamous-cell-cancer
#3
Hyun Moon, Young Jun Choi, Yoon Se Lee, Sang Wook Lee, Sung Bae Kim, Jong-Lyel Roh, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
OBJECTIVES: Radiological extranodal extension (rENE) upon CT is obtained before concurrent chemoradiation therapy (CCRT) for head and neck squamous cell carcinoma (HNSCC). We evaluated the prognostic value of rENE, rather than pathologically proven ENE, in patients who received CCRT for HNSCC. MATERIALS AND METHODS: We reviewed 117 patients. We divided the patients into rENE(+) and rENE(-) groups and evaluated overall survival (OS) and disease-specific survival (DSS), and factors affecting these outcomes...
November 6, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29103745/assessment-of-adjuvant-therapy-in-resected-head-and-neck-cancer-with-high-risk-features
#4
Gaurav S Ajmani, Cheryl C Nocon, Chi-Hsiung Wang, Mihir K Bhayani
OBJECTIVES: Subgroup analysis from two randomized trials showed a survival benefit for adjuvant chemoradiation (CRT) over radiation alone (RT) in patients with extracapsular spread (ECS) of involved lymph nodes and/or positive margins (PM) in resected head and neck cancer (HNSCC). However, results were not analyzed separately for patients with ECS or PM and were not stratified by tumor subsite/HPV status. We therefore sought to determine whether adjuvant CRT is associated with a survival benefit, separately among patients with ECS or PM and stratified by subsite/HPV status...
November 2017: Oral Oncology
https://www.readbyqxmd.com/read/29102455/postsurgical-disfigurement-influences-disgust-recognition-a-case-control-study
#5
Quentin Lisan, Nathalie George, Stephane Hans, Ollivier Laccourreye, Cédric Lemogne
BACKGROUND: Little is known about how emotion recognition may be modified in individuals prone to elicit disgust. OBJECTIVE: We sought to determine if subjects with total laryngectomy would present a modified recognition of facial expressions of disgust. METHODS: A total of 29 patients presenting with a history of advanced-stage laryngeal cancer were recruited, 17 being surgically treated (total laryngectomy) and 12 treated with chemoradiation therapy only...
September 21, 2017: Psychosomatics
https://www.readbyqxmd.com/read/29096401/inhibitor-of-dna-binding-2-is-a-novel-therapeutic-target-for-stemness-of-head-and-neck-squamous-cell-carcinoma
#6
Woo Jin Bae, Bon Seok Koo, Sang Hyuk Lee, Jin Man Kim, Young Soo Rho, Jae Yol Lim, Jung Hwa Moon, Jae Hoon Cho, Young Chang Lim
BACKGROUND: Head and neck squamous cell carcinomas (HNSCCs) are highly lethal epithelial tumours containing self-renewal cancer stem cells (CSCs). CSCs in HNSCCs are strongly associated with tumour initiation, invasion, and chemoradiation resistance. However, the important factors regulating stemness in HNSCCs remain unclear. Here, we investigated the molecular roles and clinical significance of inhibitor of DNA binding 2 (Id2) protein to determine if it constitutes a novel therapeutic target for ablating HNSCC cells with stemness...
November 2, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29080963/trends-in-treatment-incidence-and-survival-of-hypopharynx-cancer-a-20-year-population-based-study-in-the-netherlands
#7
Japke F Petersen, Adriana J Timmermans, Boukje A C van Dijk, Lucy I H Overbeek, Laura A Smit, Frans J M Hilgers, Martijn M Stuiver, Michiel W M van den Brekel
Hypopharynx cancer has the worst prognosis of all head and neck squamous cell cancers. Since the 1990s, a treatment shift has appeared from a total laryngectomy towards organ preservation therapies. Large randomized trials evaluating treatment strategies for hypopharynx cancer, however, remain scarce, and frequently this malignancy is evaluated together with larynx cancer. Therefore, our aim was to determine trends in incidence, treatment and survival of hypopharynx cancer. We performed a population-based cohort study including all patients diagnosed with T1-T4 hypopharynx cancer between 1991 and 2010 in the Netherlands...
October 28, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29063984/esophageal-squamous-cell-neoplasia-is-an-independent-negative-prognostic-factor-for-head-and-neck-cancer-patients
#8
Yasuhiko Hamada, Toshiro Mizuno, Kyosuke Tanaka, Masaki Katsurahara, Noriyuki Horiki, Reiko Yamada, Hiroyuki Inoue, Yoshiyuki Takei, Naoyuki Katayama
BACKGROUND: Patients with head and neck cancer (HNC) have a high incidence of esophageal squamous cell neoplasms (ESCN). ESCN also has a negative impact on the survival of HNC patients. However, recent endoscopic advances enable the early detection of ESCN, and novel treatments may lead to improving survival rates for HNC patients with ESCN. METHODS: HNC patients who underwent magnifying esophagogastroduodenoscopy (EGDS) from 2005 to 2012 were included in this study (n = 226)...
October 24, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29061642/multilayered-omics-based-analysis-of-a-head-and-neck-cancer-model-of-cisplatin-resistance-reveals-intratumoral-heterogeneity-and-treatment-induced-clonal-selection
#9
Franziska Niehr, Theresa Eder, Tanja Pilz, Robert Konschak, Denise Treue, Frederick Klauschen, Michael Bockmayr, Seval Türkmen, Korinna Jöhrens, Volker Budach, Ingeborg Tinhofer
PURPOSE: Platinum-based drugs, in particular cisplatin (CDDP), are used for treatment of squamous cell carcinoma of the head and neck (SCCHN). Despite initial responses, CDDP treatment often results in chemoresistance, leading to therapeutic failure. The role of primary resistance at subclonal level and treatment-induced clonal selection in the development of CDDP resistance remains unknown. EXPERIMENTAL DESIGN: By applying targeted next-generation sequencing, fluorescence in-situ hybridization, microarray-based transcriptome and mass spectrometry-based phosphoproteome analysis to the CDDP-sensitive SCCHN cell line FaDu, a CDDP-resistant subline and single-cell derived subclones, the molecular basis of CDDP resistance was elucidated...
October 23, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29044458/patient-reported-quality-of-life-outcomes-after-de-escalated-chemoradiation-for-human-papillomavirus-positive-oropharyngeal-carcinoma-findings-from-a-phase-2-trial
#10
John V Hegde, Narek Shaverdian, Megan E Daly, Carol Felix, Deborah L Wong, Michael H Rosove, Jordan H Garst, Pin-Chieh Wang, Darlene Veruttipong, Shyam Rao, Ruben C Fragoso, Jonathan W Riess, Michael L Steinberg, Allen M Chen
BACKGROUND: The current study represents a subset analysis of quality-of-life (QOL) outcomes among patients treated on a phase 2 trial of de-escalated chemoradiation for human papillomavirus (HPV)-associated oropharyngeal cancer. METHODS: Eligibility included newly diagnosed, (American Joint Committee on Cancer, 7th edition) stage III or IV oropharyngeal squamous cell carcinoma, p16 positivity, age ≥ 18 years, and a Zubrod performance status of 0 to 1. Treatment was induction paclitaxel at a dose of 175 mg/m(2) and carboplatin at an area under the curve of 6 for 2 cycles followed by response-adapted, dose-reduced radiation of 54 Gy or 60 Gy with weekly concurrent paclitaxel at a dose of 30 mg/m(2) ...
October 17, 2017: Cancer
https://www.readbyqxmd.com/read/29018502/persistent-tracheostomy-after-organ-preservation-protocol-in-patients-treated-for-larynx-and-hypopharynx-cancer
#11
Carlos Miguel Chiesa Estomba, Frank Alberto Betances Reinoso, Virginia Martinez Villasmil, Maria Jesus González Cortés, Carmelo Santidrian Hidalgo
Introduction  Squamous cell carcinoma of the larynx is currently the second most common malignancy of the airway after lung cancer, and hypopharyngeal cancer accounts for fewer than 5% of head and neck cancers. The nonsurgical options for patients with this disease are related to significant long-term toxicities and the need for persistent tracheostomy, which adversely affects the quality of life of these patients. Objective  To evaluate the need for tracheostomy, and the influence of this in the overall and specific survival rates of patients diagnosed with all stages of laryngeal carcinoma treated by chemoradiotherapy...
October 2017: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/28978005/bazedoxifene-enhances-the-anti-tumor-effects-of-cisplatin-and-radiation-treatment-by-blocking-il-6-signaling-in-head-and-neck-cancer
#12
Arti Yadav, Bhavna Kumar, Theodoros N Teknos, Pawan Kumar
Recent studies have shown that IL-6 signaling plays an important role in the aggressive and metastatic phenotype of head and neck squamous cell carcinoma (HNSCC). Therefore, we hypothesized that targeting of IL-6 signaling in HNSCC could enhance the therapeutic efficacy of standard chemoradiation treatment. We used both in vitro and in vivo models to test the efficacy of Bazedoxifene (BZA), a drug that was originally developed as a newer-generation selective estrogen receptor modulator (SERM) for the treatment of postmenopausal osteoporosis...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28975121/epidemiology-and-outcomes-of-nasopharyngeal-carcinoma-experience-from-a-regional-cancer-center-in-southern-india
#13
Rudresha Antapura Haleshappa, Aditi Harsh Thanky, Lakshmaiah Kuntegowdanahalli, Govind Babu Kanakasetty, Lokanatha Dasappa, Linu Jacob
CONTEXT: Nasopharyngeal carcinoma (NPC) is a rare head and neck cancer with significant geographical variation. There are limited data on epidemiology and outcomes of NPC reported from Southern India. SETTINGS AND DESIGN: Retrospective analysis. MATERIALS AND METHODS: We analyzed our hospital data between January 2005 and December 2011 with NPC and analyzed their demographic parameters and outcomes with therapy. RESULTS: A total 143 cases of NPC were identified...
July 2017: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/28963807/role-of-macrophage-migration-inhibitory-factor-in-head-and-neck-cancer-and-novel-therapeutic-targets-a-systematic-review
#14
Jérôme R Lechien, Amir Nassri, Nadege Kindt, David N Brown, Fabrice Journe, Sven Saussez
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine involved in systemic, autoimmune, and inflammatory diseases, such as obesity, rheumatoid arthritis, and systemic lupus erythematosus. For the 2 past decades, MIF has been reported to participate in carcinogenesis, disease prognosis, tumor cell proliferation, invasion, and tumor-induced angiogenesis in many cancers. The purpose of this article is to review published experimental and clinical data for MIF and its involvement in upper aerodigestive tract cancers...
September 30, 2017: Head & Neck
https://www.readbyqxmd.com/read/28942587/randomized-control-trial-of-benzydamine-hcl-versus-sodium-bicarbonate-for-prophylaxis-of-concurrent-chemoradiation-induced-oral-mucositis
#15
Imjai Chitapanarux, Tharatorn Tungkasamit, Janjira Petsuksiri, Danita Kannarunimit, Kanyarat Katanyoo, Chakkapong Chakkabat, Jiraporn Setakornnukul, Somying Wongsrita, Naruemon Jirawatwarakul, Chawalit Lertbusayanukul, Patumrat Sripan, Patrinee Traisathit
PURPOSE: The purpose of the study is to compare the efficacy of benzydamine HCl with sodium bicarbonate in the prevention of concurrent chemoradiation-induced oral mucositis in head and neck cancer patients. METHODS: Sixty locally advanced head and neck cancer patients treated with high-dose radiotherapy concurrently with platinum-based chemotherapy were randomly assigned to receive either benzydamine HCl or sodium bicarbonate from the first day of treatment to 2 weeks after the completion of treatment...
September 23, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28940024/predictors-of-health-related-quality-of-life-in-patients-treated-with-neck-dissection-for-head-and-neck-cancer
#16
Elise M Gane, Steven M McPhail, Anna L Hatton, Benedict J Panizza, Shaun P O'Leary
Patients with head and neck cancer can report reduced health-related quality of life several years after treatment. The aim of this study was to identify risk factors for reduced quality of life in patients up to 5 years following neck dissection. This cross-sectional study was conducted at two hospitals in Brisbane, Australia. Patients completed two measures of quality of life: the Neck Dissection Impairment Index (NDII), a region- and disease-specific tool, and the Assessment of Quality of Life-4 Domains, a general tool...
December 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28911070/induction-tpf-followed-by-concomitant-treatment-versus-concomitant-treatment-alone-in-locally-advanced-head-and-neck-cancer-a-phase-ii-iii-trial
#17
M G Ghi, A Paccagnella, D Ferrari, P Foa, D Alterio, C Codecà, F Nolè, E Verri, R Orecchia, F Morelli, S Parisi, C Mastromauro, C A Mione, C Rossetto, M Polsinelli, H Koussis, L Loreggian, A Bonetti, F Campostrini, G Azzarello, C D'Ambrosio, F Bertoni, C Casanova, E Emiliani, M Guaraldi, F Bunkheila, P Bidoli, R M Niespolo, A Gava, E Massa, A Frattegiani, F Valduga, G Pieri, T Cipani, D Da Corte, F Chiappa, E Rulli
Background: Platinum-based chemoradiation (CCRT) is the standard treatment for Locally Advanced Head and Neck Squamous-Cell Carcinoma (LAHNSCC). Cetuximab/RT (CET/RT) is an alternative treatment option to CCRT. The efficacy of induction chemotherapy (IC) followed by chemoradiation compared to chemoradiation alone has not been demonstrated in randomized clinical trials. The goals of this phase II-III trial were to assess: (i) the overall survival (OS) of IC versus no-induction (no-IC) and (ii) the Grade 3-4 in-field mucosal toxicity of CCRT versus CET/RT...
September 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28899969/tmem16a-ano1-inhibits-apoptosis-via-downregulation-of-bim-expression
#18
Neal R Godse, Nayel Khan, Zachary A Yochum, Roberto Gomez-Casal, Carolyn Kemp, Daniel J Shiwarski, Raja S Seethala, Scott Kulich, Mukund Seshadri, Timothy F Burns, Umamaheswar Duvvuri
Purpose: TMEM16A is a calcium-activated chloride channel that is amplified in a variety of cancers, including 30% of head and neck squamous cell carcinomas (HNSCCs), raising the possibility of an anti-apoptotic role in malignant cells. This study investigated this using a multimodal, translational investigation.Experimental Design: Combination of (i) in vitro HNSCC cell culture experiments assessing cell viability, apoptotic activation, and protein expression (ii) in vivo studies assessing similar outcomes, and (iii) molecular and staining analysis of human HNSCC samples...
September 12, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28870248/functional-and-quality-of-life-outcomes-after-partial-glossectomy-a-multi-institutional-longitudinal-study-of-the-head-and-neck-research-network
#19
Agnieszka Dzioba, Daniel Aalto, Georgina Papadopoulos-Nydam, Hadi Seikaly, Jana Rieger, Johan Wolfaardt, Martin Osswald, Jeffrey R Harris, Daniel A O'Connell, Cathy Lazarus, Mark Urken, Ilya Likhterov, Raymond L Chai, Erika Rauscher, Daniel Buchbinder, Devin Okay, Risto-Pekka Happonen, Ilpo Kinnunen, Heikki Irjala, Tero Soukka, Juhani Laine
BACKGROUND: While aggressive treatment for oral cancer may optimize survival, decrements in speech and swallowing function and quality of life often result. This exploratory study investigated how patients recover their communicative function, swallowing ability, and quality of life after primary surgery [with or without adjuvant (chemo)radiation therapy] for tongue cancer over the course of the first year post-operation. METHODS: Patients treated for oral cancer at three institutions (University of Alberta Hospital, Mount Sinai Beth Israel Medical Center, and Turku University Hospital) were administered patient-reported outcomes assessing speech [Speech Handicap Index (SHI)], swallowing [(M...
September 4, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28833217/adjuvant-chemoradiation-does-not-improve-survival-in-elderly-patients-with-high-risk-resected-head-and-neck-cancer
#20
Nicholas J Giacalone, Muhammad M Qureshi, Kimberley S Mak, Diana Kirke, Sagar A Patel, Bhartesh A Shah, Andrew R Salama, Scharukh Jalisi, Minh Tam Truong
OBJECTIVES/HYPOTHESIS: Randomized trials have demonstrated that adjuvant chemoradiotherapy (CRT) confers an overall survival (OS) benefit over adjuvant radiation therapy (RT) alone in patients with resected head and neck squamous cell carcinoma (HNSCC) with adverse pathologic features (positive surgical margins [SM+] and/or extracapsular extension [ECE]). Whether this OS benefit exists in an elderly population remains unknown. STUDY DESIGN: Retrospective database study...
August 21, 2017: Laryngoscope
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