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Chemoradiation head and neck cancer

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https://www.readbyqxmd.com/read/27881143/weekly-versus-every-three-weeks-platinum-based-chemoradiation-regimens-for-head-and-neck-cancer
#1
James M Melotek, Benjamin T Cooper, Matthew Koshy, Joshua S Silverman, Michael T Spiotto
BACKGROUND: The majority of chemoradiation (CRT) trials for locally advanced head and neck squamous cell carcinoma (HNSCC) have relied on platinum-based chemotherapy regimens administered every-3-weeks. However, given the increased utilization of weekly platinum regimens, it remains unclear how different chemotherapy schedules compare regarding efficacy and toxicity. METHODS: We retrospectively identified 212 patients with HNSCC who were treated at a single academic medical center with concurrent platinum-based CRT given weekly (N = 68) or every-three-weeks (N = 144)...
November 24, 2016: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27869097/the-impact-of-radiation-treatment-time-on-survival-in-patients-with-head-and-neck-cancer
#2
Talha Shaikh, Elizabeth A Handorf, Colin T Murphy, Ranee Mehra, John A Ridge, Thomas J Galloway
PURPOSE: To assess the impact of radiation treatment time (RTT) in head and neck cancers on overall survival (OS) in the era of chemoradiation. METHODS AND MATERIALS: Patients with diagnoses of tongue, hypopharynx, larynx, oropharynx, or tonsil cancer were identified by use of the National Cancer Database. RTT was defined as date of first radiation treatment to date of last radiation treatment. In the definitive setting, prolonged RTT was defined as >56 days, accelerated RTT was defined as <47 days, and standard RTT was defined as 47 to 56 days...
December 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27833872/effects-of-chemoradiation-on-hearing-in-patients-with-head-and-neck-malignancies-experience-at-a-tertiary-referral-care-hospital
#3
Abhineet Jain, Praveer K Banerjee, D Manjunath
Hearing loss as a side effect in patients with head and neck malignancies with chemoradiation is frequently ignored. Its effects on auditory functions are less studied and there are studies done on animals which are less reliable. The present study was undertaken to identify the type of hearing loss and also to quantify the degree of hearing loss in these patients. A prospective, descriptive study was undertaken in histologically proven head and neck cancer patients treated with cobalt 60 teletherapy who received a dose of 60-66 Grays (Gy) over a period of 6-7 weeks with concurrent Cisplatin 30 mg/m(2) once weekly for 6 weeks...
December 2016: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/27764854/-head-and-neck-cancer-in-pregnancy-recommendations-for-diagnosis-and-therapy-with-case-report
#4
C Mozet, T Kuhnt, B Sattler, J Remmele, U Thome, H Stepan, R Kluge, A Dietz, M Knoedler
Objective: The diagnosis of cancer in pregnancy is rare, but might become more relevant even for head and neck cancer patients due to a shift of age of primipara towards the last third of reproductive years. Unsureness exists about the risk and benefit of diagnostic and therapeutic cancer modalities for the unborn and established recommendations are still missing. But, according to recent data, even multimodal therapeutic approaches (e. g. surgery, radiation, chemotherapy) seem possible in face of pregnancy and should be traded against the risk of prematurity...
October 2016: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/27764820/on-01910-na-rigosertib-inhibits-pi3k-akt-pathway-and-activates-oxidative-stress-signals-in-head-and-neck-cancer-cell-lines
#5
Anil Prasad, Nagina Khudaynazar, Ramana V Tantravahi, Amanda M Gillum, Benjamin S Hoffman
Squamous cell carcinoma of the head and neck (HNSCC) is characterized by high morbidity and mortality. Treatment failure, drug resistance and chemoradiation toxicity have necessitated the development of alternative treatment strategies. Styryl benzyl sulfones, a family of novel small molecule inhibitors, are being evaluated as anti-neoplastic agents in multiple clinical trials. The activity of these compounds has been well characterized in several preclinical tumor studies, but their activity has yet to be fully examined in HNSCC...
October 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27755996/treatment-de-intensification-strategies-for-head-and-neck-cancer
#6
REVIEW
Jacqueline R Kelly, Zain A Husain, Barbara Burtness
Increasingly, squamous cell carcinoma of the oropharynx (OPSCC) is attributable to transformation resulting from high-risk human papillomavirus (HPV) infection. Such cancers are significantly more responsive to treatment than traditional tobacco- and alcohol-associated squamous cell cancers of the head and neck. Conventional management with definitive chemoradiation, surgery and adjuvant radiation, or radiation given with altered fractionation schemes, while effective, incurs long-term morbidity that escalates with treatment intensity and significantly impairs quality of life...
November 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27746305/dusquetide-a-novel-innate-defense-regulator-demonstrating-a-significant-and-consistent-reduction-in-the-duration-of-oral-mucositis-in-preclinical-data-and-a-randomized-placebo-controlled-phase-2a-clinical-study
#7
Mahesh Kudrimoti, Amarintha Curtis, Samar Azawi, Francis Worden, Sanford Katz, Douglas Adkins, Marcelo Bonomi, Jenna Elder, Stephen T Sonis, Richard Straube, Oreola Donini
Dusquetide, a novel Innate Defense Regulator, modulates the innate immune system at a key convergence point in intracellular signaling pathways and has demonstrated activity in both reducing inflammation and increasing clearance of bacterial infection. Innate immunity has also been implicated in the pathogenesis of oral mucositis (OM), a universal toxicity of chemoradiation therapy (CRT). Testing the hypothesis that dusquetide can mitigate the development and duration of OM, preclinical studies have been completed and correlated with interim results from a Phase 2 clinical study in patients undergoing CRT for head and neck cancer...
October 13, 2016: Journal of Biotechnology
https://www.readbyqxmd.com/read/27745982/salivary-cytokine-levels-and-oral-mucositis-in-head-and-neck-cancer-patients-treated-with-chemotherapy-and-radiation-therapy
#8
Paolo Bossi, Cristiana Bergamini, Rosalba Miceli, Agata Cova, Ester Orlandi, Carlo Resteghini, Laura Locati, Salvatore Alfieri, Martina Imbimbo, Roberta Granata, Luigi Mariani, Nicola Alessandro Iacovelli, Veronica Huber, Anna Cavallo, Lisa Licitra, Licia Rivoltini
PURPOSE: We assessed the presence of salivary cytokines, their modulation during chemoradiation therapy (CTRT), and their association with oral mucositis severity in patients with head and neck cancer (HNC). METHODS AND MATERIALS: The present prospective observational study enrolled 55 patients with locally advanced HNC requiring CTRT. We also studied 10 healthy volunteers and 10 patients with other cancers. The salivary levels of 13 cytokines were analyzed. We constructed a cytokine predictive score of oral mucositis severity...
December 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27734981/malignant-salivary-gland-tumours-of-the-larynx-a-single-institution-review
#9
S Karatayli-Ozgursoy, J A Bishop, A T Hillel, L M Akst, S R Best
Malignant salivary gland tumours of the larynx are very rare, with limited reports of clinical outcomes. We present the decade-long experience of a single institution. A 10-year retrospective chart review of a tertiary head and neck cancer centre was performed. Index patients were identified from a review of a pathology database, and reviewed by a head and neck pathologist. Patient demographics, presenting signs and symptoms, treatment modalities and clinical outcomes were extracted from electronic medical records...
August 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27726241/earlier-and-more-specific-detection-of-persistent-neck-disease-with-diffusion-weighted-mri-versus-subsequent-pet-ct-after-definitive-chemoradiation-for-oropharyngeal-squamous-cell-carcinoma
#10
Yao Yu, Marc Mabray, William Silveira, Peter Y Shen, William R Ryan, Alina Uzelac, Sue S Yom
BACKGROUND: The purpose of this study was to test if diffusion-weighted imaging (DWI) identified persistent neck disease after chemoradiotherapy (CRT) for oropharyngeal cancer earlier and as accurately as subsequent positron emission tomography (PET)/CT. METHODS: We performed a review of patients with oropharyngeal cancer treated with definitive CRT who underwent DWI and PET/CT at a median of 8 and 14 weeks posttreatment. Imaging characteristics were correlated with pathologically proven neck failure...
October 11, 2016: Head & Neck
https://www.readbyqxmd.com/read/27724969/survival-outcomes-in-patients-with-oropharyngeal-cancer-treated-with-carboplatin-paclitaxel-and-concurrent-radiotherapy
#11
M Roskies, E Kay-Rivest, M A Mascarella, K Sultanem, A Mlynarek, M Hier
BACKGROUND: A commonly employed treatment for advanced staged oropharyngeal squamous cell carcinoma (OPSCC) is concurrent radiation and chemotherapy with cisplatin as the gold standard. Carboplatin is reported to have the same radiopotentiation properties and a superior side effect profile; however, its use in head and neck cancer has been limited due to the paucity of data and reported hematologic side effects. In this study, we describe our institution's experience with carboplatin, paclitaxel and radiation in the treatment of oropharyngeal squamous cell carcinoma over a 10 year period...
October 10, 2016: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27716125/dars-a-phase-iii-randomised-multicentre-study-of-dysphagia-optimised-intensity-modulated-radiotherapy-do-imrt-versus-standard-intensity-modulated-radiotherapy-s-imrt-in-head-and-neck-cancer
#12
Imran Petkar, Keith Rooney, Justin W G Roe, Joanne M Patterson, David Bernstein, Justine M Tyler, Marie A Emson, James P Morden, Kathrin Mertens, Elizabeth Miles, Matthew Beasley, Tom Roques, Shreerang A Bhide, Kate L Newbold, Kevin J Harrington, Emma Hall, Christopher M Nutting
BACKGROUND: Persistent dysphagia following primary chemoradiation (CRT) for head and neck cancers can have a devastating impact on patients' quality of life. Single arm studies have shown that the dosimetric sparing of critical swallowing structures such as the pharyngeal constrictor muscle and supraglottic larynx can translate to better functional outcomes. However, there are no current randomised studies to confirm the benefits of such swallow sparing strategies. The aim of Dysphagia/Aspiration at risk structures (DARS) trial is to determine whether reducing the dose to the pharyngeal constrictors with dysphagia-optimised intensity- modulated radiotherapy (Do-IMRT) will lead to an improvement in long- term swallowing function without having any detrimental impact on disease-specific survival outcomes...
October 6, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27675039/epigallocatechin-3-gallate-mouthwash-mitigates-oral-mucositis-in-patients-with-head-and-neck-cancer-receiving-chemoradiation-therapy-radiation-therapy
#13
H Zhao, W Zhu, G Chen, L Jia, X Sun, L Xing, J Yu
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674549/posttreatment-positron-emission-tomography-computed-tomography-and-p16-status-for-neck-management-in-locally-advanced-head-and-neck-cancer-after-definitive-chemoradiation
#14
M J Awan, P Lavertu, C Zender, R Rezaee, N Fowler, M Gibson, J Wasman, P Faulhaber, M Machtay, M Yao
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674464/the-role-of-positron-emission-tomography-computed-tomography-in-head-and-neck-cancer-after-radical-chemoradiation-therapy
#15
C Nelissen, A Hartley, J Sherriff, T Jones, P Guest, S Colley, P Sanghera
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674454/pooled-analysis-of-late-toxicity-from-2-randomized-phase-2-trials-of-induction-chemotherapy-ic-and-chemoradiation-therapy-crt-for-locally-advanced-head-and-neck-squamous-cell-cancer-la-hnscc
#16
J M Melotek, V M Villaflor, T Y Seiwert, M Kocherginsky, T G Karrison, R J Brisson, E A Blair, K M Stenson, M Lingen, E Cohen, E E Vokes, D J Haraf
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674398/comparison-of-chemoradiation-versus-radiation-alone-for-elderly-patients-with-locally-advanced-head-and-neck-squamous-cell-carcinoma-an-analysis-of-the-national-cancer-data-base
#17
N J Giacalone, M M Qureshi, K S Mak, D Kirke, B A Shah, S A Patel, A Salama, S Jalisi, M T Truong
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674385/beyond-positive-margins-and-extracapsular-extension-evaluating-the-impact-of-postoperative-chemoradiation-therapy-in-locally-advanced-head-and-neck-cancer
#18
D M Trifiletti, A Lin, J N Lukens, W M Mendenhall, N Mitra, P W Read, S Swisher-Mcclure
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27564254/bazedoxifene-enhances-the-anti-tumor-effects-of-cisplatin-and-radiation-treatment-by-blocking-il-6-signaling-in-head-and-neck-cancer
#19
Arti Yadav, Bhavna Kumar, Theodoros N Teknos, Pawan Kumar
Recent studies have shown that IL-6 signaling plays an important role in the aggressive and metastatic phenotype of head and neck squamous cell carcinoma (HNSCC). Therefore, we hypothesized that targeting of IL-6 signaling in HNSCC could enhance the therapeutic efficacy of standard chemoradiation treatment. We used both in vitro and in vivo models to test the efficacy of Bazedoxifene (BZA), a drug that was originally developed as a newer-generation selective estrogen receptor modulator (SERM) for the treatment of postmenopausal osteoporosis...
August 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/27561463/safety-of-drug-treatments-for-head-and-neck-cancer
#20
Rachel Galot, Jean-Pascal Machiels
INTRODUCTION: The treatment of squamous cell carcinoma of the head and the neck depends on the disease's stage. In locally-advanced stage disease, multimodal treatment strategies, including surgery, radiotherapy and chemotherapy, give the best outcome in terms of overall survival. Those treatments are not without negligeable adverse events, which can lead to late debilitating toxicities. In recurrent/metastatic disease, not amenable to surgery or radiation therapy, palliative chemotherapy is the most appropriate treatment...
September 9, 2016: Expert Opinion on Drug Safety
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