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Chemoradiation head and neck cancer

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https://www.readbyqxmd.com/read/29329660/cochlea-ct-radiomics-predicts-chemoradiotherapy-induced-sensorineural-hearing-loss-in-head-and-neck-cancer-patients-a-machine-learning-and-multi-variable-modelling-study
#1
Hamid Abdollahi, Shayan Mostafaei, Susan Cheraghi, Isaac Shiri, Seied Rabi Mahdavi, Anoshirvan Kazemnejad
OBJECTIVES: Immediately or after head-and-neck (H&N) cancer chemoradiotherapy (CRT), patients may undergone significant sensorineural hearing loss (SNHL) which could affect their quality of life. Radiomic feature analysis is proposed to predict SNHL induced by CRT. MATERIAL AND METHODS: 490 image features of 94 cochlea from 47 patients treated with three dimensional conformal RT (3DCRT) for different H&N cancers were extracted from CT images. Different machine learning (ML) algorithms and also least absolute shrinkage and selection operator (LASSO) penalized logistic regression were implemented on radiomic features for feature selection, classification and prediction...
January 9, 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29323575/phase-ii-investigational-oral-drugs-for-the-treatment-of-radio-chemotherapy-induced-oral-mucositis
#2
Stephen T Sonis, Alessandro Villa
Oral mucositis is a significant unmet clinical need for many cancer patients. The biological complexity of mucositis' pathogenesis provides a number of mechanistic targets suitable as pharmacologic targets. The diversity of targets has stimulated drug development in search of an effective intervention. In this paper, we review a range of agents that are currently being evaluated. Areas covered: Drugs for management of oral mucositis vary in formulation, route of administration and biological target. Most propose to interrupt the initiation of injury by suppressing activation of the innate immune response or countering oxidative stress, or minimizing downstream inflammatory responses...
January 11, 2018: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/29323421/head-and-neck-cancer-tumor-seeding-at-the-percutaneous-endoscopic-gastrostomy-site
#3
REVIEW
June R Greaves
The National Institutes of Health National Cancer Institute estimates that over 13,000 new cases of head and neck cancer (HNC) will be diagnosed in 2017. Patients with HNC often require enteral nutrition (EN) via gastrostomy tube to provide nutrition support and hydration because of tumor obstruction of the oropharynx and/or cumulative effects of chemoradiation therapy. The percutaneous endoscopic gastrostomy (PEG) tube has become the preferred technique for EN access because placement is considered a minimally invasive procedure...
January 11, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29280493/the-effects-of-concurrent-chemoradiation-therapy-to-the-base-of-tongue-in-a-preclinical-model
#4
Peter A Benedict, Ryan Ruiz, Avanti Verma, Gregory R Dion, Philmo Oh, Binhuan Wang, Omar H Ahmed, Nao Hiwatashi, Renjie Bing, Kristen Victor, Kenneth S Hu, Aaron Johnson, Ryan C Branski, Milan R Amin
OBJECTIVES/HYPOTHESIS: To develop a clinically relevant model of oropharyngeal concurrent chemoradiation therapy (CCRT) in order to quantify the effects of CCRT on tongue function and structure. CCRT for advanced oropharyngeal cancer commonly leads to tongue base dysfunction and dysphagia. However, no preclinical models currently exist to study the pathophysiology of CCRT-related morbidity, thereby inhibiting the development of targeted therapeutics. STUDY DESIGN: Animal model...
December 27, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29250200/update-on-squamous-cell-carcinoma-of-the-head-and-neck-asco-annual-meeting-2017
#5
REVIEW
Teresa Magnes, Alexander Egle, Richard Greil, Thomas Melchardt
At the annual ASCO meeting clinically relevant data concerning the management of advanced head and neck cancer that will influence clinical practice in the future were presented. Chemoradiation with high-dose cisplatin remains the mainstay of treatment for patients with locally advanced squamous cell head and neck cancer. Adjuvant therapy with afatinib following chemoradiation failed to show clinical benefit. The combination of bevacizumab with platinum-based chemotherapy improved progression-free survival but did not lead to a significant difference in overall survival compared to chemotherapy alone...
2017: Memo
https://www.readbyqxmd.com/read/29246721/functional-outcomes-after-de-escalated-chemoradiation-therapy-for-human-papillomavirus-positive-oropharyngeal-cancer-secondary-analysis-of-a-phase-2-trial
#6
John V Hegde, Narek Shaverdian, Carol Felix, Pin-Chieh Wang, Darlene Veruttipong, Sophia Hsu, Jonathan W Riess, Shyam D Rao, Megan E Daly, Allen M Chen
PURPOSE: To analyze functional outcomes for patients treated on a phase 2 trial of de-escalated chemoradiation therapy for human papillomavirus-positive oropharyngeal cancer. METHODS AND MATERIALS: Patient eligibility included p16-positive, stage III or IV oropharyngeal squamous cell carcinoma and a Zubrod performance status of 0 to 1. Treatment was induction chemotherapy with paclitaxel, 175 mg/m2, and carboplatin, area under the curve (AUC) of 6 mg/ml/min, for 2 cycles every 21 days, followed by concurrent paclitaxel, 30 mg/m2, every 7 days with dose-reduced radiation therapy of 54 or 60 Gy...
November 6, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29220295/once-a-week-versus-once-every-3-weeks-cisplatin-chemoradiation-for-locally-advanced-head-and-neck-cancer-a-phase-iii-randomized-noninferiority-trial
#7
Vanita Noronha, Amit Joshi, Vijay Maruti Patil, Jaiprakash Agarwal, Sarbani Ghosh-Laskar, Ashwini Budrukkar, Vedang Murthy, Tejpal Gupta, Anil K D'Cruz, Shripad Banavali, Prathamesh S Pai, Pankaj Chaturvedi, Devendra Chaukar, Nikhil Pande, Arun Chandrasekharan, Vikas Talreja, Dilip Harindran Vallathol, Vijayalakshmi Mathrudev, Aparna Manjrekar, Kamesh Maske, Arati Sanjay Bhelekar, Kavita Nawale, Sadhana Kannan, Vikram Gota, Atanu Bhattacharjee, Shubhada Kane, Shashikant L Juvekar, Kumar Prabhash
Purpose Chemoradiation with cisplatin 100 mg/m2 given once every 3 weeks is the standard of care in locally advanced head and neck squamous cell cancer (LAHNSCC). Increasingly, low-dose once-a-week cisplatin is substituted because of perceived lower toxicity and convenience. However, there is no level 1 evidence of comparable efficacy to cisplatin once every 3 weeks. Patients and Methods In this phase III randomized trial, we assessed the noninferiority of cisplatin 30 mg/m2 given once a week compared with cisplatin 100 mg/m2 given once every 3 weeks, both administered concurrently with curative intent radiotherapy in patients with LAHNSCC...
December 8, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29214640/management-of-head-and-neck-primary-unknown-squamous-cell-carcinoma-using-combined-positron-emission-tomography-computed-tomography-and-transoral-laser-microsurgery
#8
Victoria Kuta, Blair Williams, Matthew Rigby, Robert Hart, Jonathan Trites, Colin MacKay, S Mark Taylor
OBJECTIVES/HYPOTHESIS: The unknown primary of the neck is commonly encountered by the head and neck surgeon. Despite the exhaustive diagnostic tools employed in traditional detection protocols, many unknown primaries are not found, and the patient is subjected to wide-field radiation and chemotherapy during treatment. Localizing the primary tumor has demonstrated therapeutic benefits, improved quality of life, and overall survival. The authors' objective was to determine the efficacy of a new management protocol for unknown primaries of the head and neck...
December 7, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29199658/an-audit-and-analysis-of-different-causes-of-defaults-in-patients-receiving-radiation-for-head-and-neck-cancers-a-tertiary-regional-cancer-center-experience
#9
L Pujari, S Padhi, P Meher, A Tripathy
CONTEXT: Strict adherence and timely completion of the external beam radiation therapy (EBRT) schedule is an important prognostic factor in the survival of head and neck cancer patients. However, many patients are unable to complete the radiation treatment due to various reasons resulting in a poor outcome. AIMS: This study aims to study the pattern and various possible causes of defaults for possible intervention. SETTINGS AND DESIGN: A retrospective epidemiological analysis...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29192505/us-oncology-wide-incidence-duration-costs-and-deaths-from-chemoradiation-mucositis-and-antimucositis-therapy-benefits
#10
Ricky W McCullough
Approximate oncology-wide incidence, duration, costs and deaths associated with mucositis and identify health economic benefits of antimucositis therapies. Review the literature relevant to the clinical experience of mucositis by pathophysiology, incidence, duration, costs and deaths. Use US insurance actuarial and epidemiology on cancer to generalize an oncology-wide impact of toxic mucositis. Toxic mucositis causes oropharyngoesophageal ulcerations, chemo-induced nausea, vomiting and diarrhea. Acutely, it lasts 102 days/six cycles of chemotherapy, 60 days in human stem-cell transplantation patients and 70-84 days in head and neck cancer patients at annual costs of US$13...
December 1, 2017: Future Oncology
https://www.readbyqxmd.com/read/29174070/acs-nsqip-risk-calculator-reliability-in-head-and-neck-oncology-the-effect-of-prior-chemoradiation-on-nsqip-risk-estimates-following-laryngectomy
#11
Angela Cao, Sarah Khayat, Elizabeth Cash, Christopher Nickel, John Gettelfinger, Paul Tennant, Jeffrey Bumpous
PURPOSE: To determine whether inclusion of chemoradiation history increases estimated risk for complications following total laryngectomy using the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) Surgical Risk Calculator. MATERIALS AND METHODS: A retrospective review of 96 patients with laryngeal cancer, approximately half of who had received prior chemoradiation, who underwent laryngectomy between January 2010 and December 2014...
November 13, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29172863/use-of-larynx-preservation-strategies-in-the-treatment-of-laryngeal-cancer-american-society-of-clinical-oncology-clinical-practice-guideline-update
#12
Arlene A Forastiere, Nofisat Ismaila, Jan S Lewin, Cherie Ann Nathan, David J Adelstein, Avraham Eisbruch, Gail Fass, Susan G Fisher, Scott A Laurie, Quynh-Thu Le, Bernard O'Malley, William M Mendenhall, Snehal Patel, David G Pfister, Anthony F Provenzano, Randy Weber, Gregory S Weinstein, Gregory T Wolf
Purpose To update the guideline recommendations on the use of larynx-preservation strategies in the treatment of laryngeal cancer. Methods An Expert Panel updated the systematic review of the literature for the period from January 2005 to May 2017. Results The panel confirmed that the use of a larynx-preservation approach for appropriately selected patients does not compromise survival. No larynx-preservation approach offered a survival advantage compared with total laryngectomy and adjuvant therapy as indicated...
November 27, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29169511/longitudinal-and-cross-sectional-assessment-of-quality-of-life-in-surgically-treated-advanced-t4-cancer-of-the-buccal-mucosa
#13
Manish Devendra Mair, Sudhir Nair, Santosh Nikam, Deepa Nair, Jai Prakash Agarwal, Pankaj Chaturvedi
OBJECTIVE: Quality of life (QOL) has become an important aspect of today's health care management. This study performed longitudinal assessment of QOL in patients with advanced cancers of the buccal mucosa (T4). We compared the QOL between patients who received adjuvant chemoradiation therapy (CTRT) and that of patients who received radiation therapy alone and assessed whether baseline QOL can predict disease recurrence. STUDY DESIGN: This was a prospective study of 225 patients with T4 buccal mucosal cancer...
December 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29164301/changes-in-multimodality-functional-imaging-parameters-early-during-chemoradiation-predict-treatment-response-in-patients-with-locally-advanced-head-and-neck-cancer
#14
Kee H Wong, Rafal Panek, Alex Dunlop, Dualta Mcquaid, Angela Riddell, Liam C Welsh, Iain Murray, Dow-Mu Koh, Martin O Leach, Shreerang A Bhide, Christopher M Nutting, Wim J Oyen, Kevin J Harrington, Kate L Newbold
OBJECTIVE: To assess the optimal timing and predictive value of early intra-treatment changes in multimodality functional and molecular imaging (FMI) parameters as biomarkers for clinical remission in patients receiving chemoradiation for head and neck squamous cell carcinoma (HNSCC). METHODS: Thirty-five patients with stage III-IVb (AJCC 7th edition) HNSCC prospectively underwent (18)F-FDG-PET/CT, and diffusion-weighted (DW), dynamic contrast-enhanced (DCE) and susceptibility-weighted MRI at baseline, week 1 and week 2 of chemoradiation...
November 21, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29113454/modulators-of-redox-metabolism-in-head-and-neck-cancer
#15
Xiaofei Chen, Jade Mims, Xiumei Huang, Naveen Singh, Edward A Motea, Sarah M Planchon, Muhammad Beg, Allen W Tsang, Mercedes Porosnicu, Melissa L Kemp, David A Boothman, Cristina Furdui
SIGNIFICANCE: Head and Neck Squamous Cell Cancer (HNSCC) is a complex disease characterized by high genetic and metabolic heterogeneity. Radiation therapy (RT) alone or combined with systemic chemotherapy is widely used for treatment of HNSCC as definitive treatment or as adjuvant treatment after surgery. Antibodies against Epidermal Growth Factor Receptor (EGFR) are used in definitive or palliative treatment. Recent Advances. Emerging targeted therapies against other proteins of interest as well as programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1) immunotherapies are being explored in clinical trials...
November 7, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29105549/value-of-extranodal-extension-detected-by-computed-tomography-for-predicting-clinical-response-after-chemoradiotherapy-in-head-and-neck-squamous-cell-cancer
#16
Hyun Moon, Young Jun Choi, Yoon Se Lee, Sang Wook Lee, Sung Bae Kim, Jong-Lyel Roh, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
OBJECTIVES: Radiological extranodal extension (rENE) upon CT is obtained before concurrent chemoradiation therapy (CCRT) for head and neck squamous cell carcinoma (HNSCC). We evaluated the prognostic value of rENE, rather than pathologically proven ENE, in patients who received CCRT for HNSCC. MATERIALS AND METHODS: We reviewed 117 patients. We divided the patients into rENE(+) and rENE(-) groups and evaluated overall survival (OS) and disease-specific survival (DSS), and factors affecting these outcomes...
November 6, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29103745/assessment-of-adjuvant-therapy-in-resected-head-and-neck-cancer-with-high-risk-features
#17
Gaurav S Ajmani, Cheryl C Nocon, Chi-Hsiung Wang, Mihir K Bhayani
OBJECTIVES: Subgroup analysis from two randomized trials showed a survival benefit for adjuvant chemoradiation (CRT) over radiation alone (RT) in patients with extracapsular spread (ECS) of involved lymph nodes and/or positive margins (PM) in resected head and neck cancer (HNSCC). However, results were not analyzed separately for patients with ECS or PM and were not stratified by tumor subsite/HPV status. We therefore sought to determine whether adjuvant CRT is associated with a survival benefit, separately among patients with ECS or PM and stratified by subsite/HPV status...
November 2017: Oral Oncology
https://www.readbyqxmd.com/read/29102455/postsurgical-disfigurement-influences-disgust-recognition-a-case-control-study
#18
Quentin Lisan, Nathalie George, Stephane Hans, Ollivier Laccourreye, Cédric Lemogne
BACKGROUND: Little is known about how emotion recognition may be modified in individuals prone to elicit disgust. OBJECTIVE: We sought to determine if subjects with total laryngectomy would present a modified recognition of facial expressions of disgust. METHODS: A total of 29 patients presenting with a history of advanced-stage laryngeal cancer were recruited, 17 being surgically treated (total laryngectomy) and 12 treated with chemoradiation therapy only...
September 21, 2017: Psychosomatics
https://www.readbyqxmd.com/read/29096401/inhibitor-of-dna-binding-2-is-a-novel-therapeutic-target-for-stemness-of-head-and-neck-squamous-cell-carcinoma
#19
Woo Jin Bae, Bon Seok Koo, Sang Hyuk Lee, Jin Man Kim, Young Soo Rho, Jae Yol Lim, Jung Hwa Moon, Jae Hoon Cho, Young Chang Lim
BACKGROUND: Head and neck squamous cell carcinomas (HNSCCs) are highly lethal epithelial tumours containing self-renewal cancer stem cells (CSCs). CSCs in HNSCCs are strongly associated with tumour initiation, invasion, and chemoradiation resistance. However, the important factors regulating stemness in HNSCCs remain unclear. Here, we investigated the molecular roles and clinical significance of inhibitor of DNA binding 2 (Id2) protein to determine if it constitutes a novel therapeutic target for ablating HNSCC cells with stemness...
November 2, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29080963/trends-in-treatment-incidence-and-survival-of-hypopharynx-cancer-a-20-year-population-based-study-in-the-netherlands
#20
Japke F Petersen, Adriana J Timmermans, Boukje A C van Dijk, Lucy I H Overbeek, Laura A Smit, Frans J M Hilgers, Martijn M Stuiver, Michiel W M van den Brekel
Hypopharynx cancer has the worst prognosis of all head and neck squamous cell cancers. Since the 1990s, a treatment shift has appeared from a total laryngectomy towards organ preservation therapies. Large randomized trials evaluating treatment strategies for hypopharynx cancer, however, remain scarce, and frequently this malignancy is evaluated together with larynx cancer. Therefore, our aim was to determine trends in incidence, treatment and survival of hypopharynx cancer. We performed a population-based cohort study including all patients diagnosed with T1-T4 hypopharynx cancer between 1991 and 2010 in the Netherlands...
October 28, 2017: European Archives of Oto-rhino-laryngology
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