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Chemoradiation head and neck cancer

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https://www.readbyqxmd.com/read/29770954/the-relationship-between-physical-impairments-quality-of-life-and-disability-of-the-neck-and-upper-limb-in-patients-following-neck-dissection
#1
Elise M Gane, Steven M McPhail, Anna L Hatton, Benedict J Panizza, Shaun P O'Leary
PURPOSE: The purpose of this study was to examine the relationship between physical impairments, quality of life and disability in patients following neck dissection, with consideration of patient and clinical characteristics. METHODS: Cross-sectional study of patients < 5 years after neck dissection for head and neck cancer. Quality of life and self-reported disability were measured with the Neck Dissection Impairment Index, Quick Disabilities of the Arm, Shoulder and Hand, and Neck Disability Index...
May 16, 2018: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29755916/a-case-of-sinonasal-undifferentiated-carcinoma-with-brain-metastases
#2
Julianna Sienna, Nhu-Tram Nguyen, Julie Arsenault, Ian Hodson, Brandon Meyers
Sinonasal undifferentiated carcinoma (SNUC) is a rare aggressive neoplasm arising in the nasal cavity and paranasal sinuses. We report a unique case of an 80-year-old man who presented with a locally advanced SNUC involving the ethmoid, sphenoid, and maxillary sinuses and bilateral lymph nodes, clinical T4N2M0. Given his age and the initial extent of his primary tumour, he was treated with neoadjuvant chemotherapy followed by chemoradiation with a split course of 50 Gray (Gy) in 40 fractions delivered twice a day...
March 13, 2018: Curēus
https://www.readbyqxmd.com/read/29743120/cavernous-sinus-involvement-in-human-papillomavirus-associated-oropharyngeal-squamous-cell-carcinoma-case-report-of-an-atypical-site-of-distant-metastasis
#3
David Forner, Derek Wilke, Matthew H Rigby, Sidney Croul, Anuradha Mishra, Emad Massoud, David B Clarke, Nathan Lamond
BACKGROUND: HPV-associated OSCC (HPV-OSCC) has been determined to be a distinct disease entity from non-HPV associated OSCC. Patients affected by HPV-OSCC generally have a more favourable prognosis, with improved rates of locoregional control and survival compared with their non-HPV counterparts. Despite this, HPV-OSCC has a similar rate of distant metastases. Interestingly, recent evidence has emerged that demonstrates more frequent atypical metastasis patterns when compared to non-HPV associated disease...
May 9, 2018: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29724411/submandibular-function-recovery-after-imrt-in-head-and-neck-cancer-a-prospective-dose-modelling-study
#4
Vedang Murthy, Shirley Lewis, Sadhana Kannan, Chira Ranjan Khadanga, Venkatesh Rangarajan, Kishore Joshi, Minakshi Gandhi, Sayak Dey, Ganesh Rokde, Ashwini Budrukkar, Tejpal Gupta, Sarbani Laskar, Jai Prakash Agarwal
PURPOSE: To estimate the dose response relationship for submandibular gland (SMG) recovery using salivary scintigraphy in patients diagnosed with head and neck cancer treated with curative image guided chemoradiation. MATERIAL AND METHODS: Ninety newly diagnosed head and neck cancer patients (T1-3, N0-2c, M0) treated with intensity modulated radiotherapy on a prospective clinical trial were assessed for salivary toxicity at predefined intervals using dynamic salivary scintigraphy...
April 30, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29710108/association-of-a-proactive-swallowing-rehabilitation-program-with-feeding-tube-placement-in-patients-treated-for-pharyngeal-cancer
#5
Gaurav S Ajmani, Cheryl C Nocon, Bruce E Brockstein, Nicholas P Campbell, Amy B Kelly, Jamie Allison, Mihir K Bhayani
Importance: A proactive speech and language pathology (SLP) program is an important component of the multidisciplinary care of patients with head and neck squamous cell carcinoma (HNSCC). Swallowing rehabilitation can reduce the rate of feeding tube placement, thereby significantly improving quality of life. Objective: To evaluate the initiation of a proactive SLP rehabilitation program at a single institution and its association with rates of feeding tube placement and dietary intake in patients with HNSCC...
April 19, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29708903/managing-the-late-effects-of-chemoradiation-on-swallowing-bolstering-the-beginning-minding-the-middle-and-cocreating-the-end
#6
Tessa Goldsmith, Marlene C Jacobson
PURPOSE OF REVIEW: Late dysphagia has a profound impact on quality of life in patients treated with chemoradiation therapy for advanced head and neck cancer and the number of survivors is growing. Traditional treatment methods are not uniformly successful in reducing the swallow impairment in these patients. RECENT FINDINGS: Manifestations of late dysphagia are complex and do not follow a uniform trajectory. Patient's experience of eating and engagement in treatment is critical given the complex, variable nature of late dysphagia...
June 2018: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/29669181/racial-disparity-in-oncologic-and-quality-of-life-outcomes-in-patients-with-locally-advanced-head-and-neck-squamous-cell-carcinomas-enrolled-in-a-randomized-phase-2-trial
#7
Margaret K Guerriero, Mary W Redman, Kelsey K Baker, Renato G Martins, Keith Eaton, Laura Q Chow, Rafael Santana-Davila, Christina Baik, Bernardo H Goulart, Sylvia Lee, Cristina P Rodriguez
BACKGROUND: To better understand patient-reported quality of life (PRQOL) for patients with head and neck cancer, PRQOL scores were collected in a clinical trial. METHODS: Patients were randomized to arm A (70 Gy of radiation with cisplatin) or arm B (70 Gy of radiation with cisplatin plus erlotinib at 150 mg daily). PRQOL scores were measured on days -7 (arm B only), 0, 30, and 180 with the University of Washington Quality of Life Questionnaire. Associations with clinical factors and outcomes were explored with linear mixed, logistic, and Cox regression models...
April 18, 2018: Cancer
https://www.readbyqxmd.com/read/29650060/gastrostomy-versus-nasogastric-tube-feeding-for-chemoradiation-patients-with-head-and-neck-cancer-the-tube-pilot-rct
#8
Vinidh Paleri, Joanne Patterson, Nikki Rousseau, Eoin Moloney, Dawn Craig, Dimitrios Tzelis, Nina Wilkinson, Jeremy Franks, Ann Marie Hynes, Ben Heaven, David Hamilton, Teresa Guerrero-Urbano, Rachael Donnelly, Stewart Barclay, Tim Rapley, Deborah Stocken
BACKGROUND: Approximately 9000 new cases of head and neck squamous cell cancers (HNSCCs) are treated by the NHS each year. Chemoradiation therapy (CRT) is a commonly used treatment for advanced HNSCC. Approximately 90% of patients undergoing CRT require nutritional support via gastrostomy or nasogastric tube feeding. Long-term dysphagia following CRT is a primary concern for patients. The effect of enteral feeding routes on swallowing function is not well understood, and the two feeding methods have, to date (at the time of writing), not been compared...
April 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29619560/dysphagia-and-oral-morbidities-in-chemoradiation-treated-head-and-neck-cancer-patients
#9
Yoshiaki Ihara, Michael A Crary, Aarthi Madhavan, David C Gregorio, Ikjae Im, Sarah E Ross, Giselle D Carnaby
This study prospectively evaluated relationships between oral morbidities and swallowing ability in head/neck cancer patients following chemoradiation therapy (CRT) and at 3 months following CRT. Thirty patients with confirmed head/neck cancer undergoing chemoradiation were assessed with a battery of swallowing measures and measures of oral morbidities related to chemoradiation (xerostomia, mucositis, pain, taste/smell, oral moisture). All measures were completed at baseline (within the first week of CRT), at 6 weeks (end of treatment), and at 3 months following chemoradiation...
April 4, 2018: Dysphagia
https://www.readbyqxmd.com/read/29608254/pretreatment-subcutaneous-adipose-tissue-predicts-the-outcomes-of-patients-with-head-and-neck-cancer-receiving-definitive-radiation-and-chemoradiation-in-taiwan
#10
Ping Ching Pai, Chi Cheng Chuang, Wen Ching Chuang, Ngan Ming Tsang, Chen Kan Tseng, Kuan Hung Chen, Tzu Chen Yen, Chien Yu Lin, Kai Ping Chang, Kin Fong Lei
We aimed to determine whether body composition assessment before treatment can predict outcomes in patients with head and neck cancer (HNC). All 881 patients with locoregional head and neck cancer treated with curative intent radiotherapy (RT) between 2005 and 2012 were retrospectively investigated. Body composition was analyzed via pre-RT planning computed tomography (CT) images. Subcutaneous adipose tissue (SAT) and skeletal muscle (SM) indices were measured cross-sectionally at the level of the third thoracic vertebra...
April 2, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29600235/assessment-of-oral-mucositis-during-concurrent-chemoradiation-of-head-and-neck-cancers-using-patient-reported-measurement-scale
#11
Nallan Csk Chaitanya, Arvind Muthukrishnan, P Karunakar, Manchala Himani, Neeharika Satya Jyothi Allam, Neha Jain
Introduction: Oral mucositis (OM) is a major challenge encountered in concurrent radiochemotherapy for the treatment of head and neck cancers. The patient reported OM symptoms scale (PROMS) was administered on these patients. The objective was to develop the similar scale in an Indian language and prescribe it population undergoing cancer treatment. Materials and Methods: PROMS scale was converted to Telugu language. Fifty-one patients took part in the study. All of them answered the 10-point questions marked their responses on 100 mm visual analog scale after thorough oral examination using WHO grading by the same examiner...
January 2018: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/29572573/longitudinal-evaluation-of-swallowing-with-videofluoroscopy-in-patients-with-locally-advanced-head-and-neck-cancer-after-chemoradiation
#12
Ekaterini Xinou, Ioannis Chryssogonidis, Anna Kalogera-Fountzila, Dimitra Panagiotopoulou-Mpoukla, Athanasia Printza
The aim of this study was to investigate the prevalence, severity, and pattern of evolution of swallowing impairments encountered in head and neck cancer (HNC) patients before and after chemoradiation (CRT) with videofluoroscopy of swallowing study (VFSS), using the modified barium swallow impairment profile (MBSImP) protocol and scoring system, and to determine the appropriate time points in which these patients should undergo VFSS post-CRT. A prospective cohort of 69 patients with locally advanced HNC underwent VFSS with the MBSImP protocol at 5 evaluation points: pre-CRT, and 1, 3, 6, and 12 months post-CRT...
March 23, 2018: Dysphagia
https://www.readbyqxmd.com/read/29520523/type-of-second-primary-malignancy-after-achieving-complete-response-by-definitive-chemoradiation-therapy-in-patients-with-esophageal-squamous-cell-carcinoma
#13
Toshifumi Yamaguchi, Ken Kato, Kengo Nagashima, Satoru Iwasa, Yoshitaka Honma, Atsuo Takashima, Tetsuya Hamaguchi, Yoshinori Ito, Jun Itami, Narikazu Boku, Kazuhide Higuchi
BACKGROUND: While the standard treatment for stage II-III (non-T4) esophageal squamous cell carcinoma (ESCC) is neoadjuvant therapy followed by esophagectomy, definitive chemoradiation therapy (dCRT) is an option to treat ESCC patients who reject or may not tolerate surgical treatment. Second primary malignancy (SPM) is a problem for long-term survivors after achieving complete response (CR) by dCRT. METHODS: The source of the subjects in this study was the patients with stage II/III (excluding T4 disease) ESCC (UICC6th) who underwent dCRT from 2000 to 2011 at the National Cancer Center Hospital, Japan...
March 8, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29469078/barriers-affecting-adherence-to-radiation-treatment-and-strategies-to-overcome-those-barriers
#14
R Rangarajan, K Jayaraman
BACKGROUND: The WHO defines adherence as the extent to which a patient's behavior coincides with recommendations from a health-care provider. Nonadherence to cancer treatment has a major impact on the therapeutic outcome. AIM OF THE STUDY: To assess the prevalence of nonadherence to radiation regimen and to analyze the factors that affect adherence to cancer treatment. MATERIALS AND METHODS: Patients receiving radiation treatment in our hospital were screened for adherence to appointment keeping and to the prescribed radiation regimen and patients who had unplanned treatment breaks during treatment were interviewed...
April 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29469077/carboplatin-based-concurrent-chemoradiation-therapy-in-locally-advanced-head-and-neck-cancer-patients-who-are-unfit-for-cisplatin-therapy
#15
V Noronha, V Sharma, A Joshi, V M Patil, S G Laskar, K Prabhash
BACKGROUND: Cisplatin-based chemoradiation (CTRT) is the standard of care in locally advanced head and neck cancers. Limited treatment options are available in patients unfit for cisplatin. AIMS: This audit was carried out to study the toxicities, tolerance, and outcomes of carboplatin-based CTRT in patients who are not eligible for cisplatin. MATERIALS AND METHODS: A total of 63 locally advanced head and neck cancer patients treated between January 2011 and October 2015 were administered carboplatin-based CTRT...
April 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29428251/adaptive-boost-target-definition-in-high-risk-head-and-neck-cancer-based-on-multi-imaging-risk-biomarkers
#16
Feifei Teng, Madhava Aryal, Jae Lee, Choonik Lee, Xioajin Shen, Peter G Hawkins, Michelle Mierzwa, Avraham Eisbruch, Yue Cao
PURPOSE: Positron emission tomography with 18 F-deoxyglucose (FDG), dynamic contrast-enhanced magnetic resonance imaging (MRI), and diffusion-weighted MRI each identify unique risk factors for treatment outcomes in head and neck cancer (HNC). Clinical trials in HNC largely rely on a single imaging modality to define targets for boosting. This study aimed to investigate the spatial correspondence of FDG uptake, perfusion, and the apparent diffusion coefficient (ADC) in HNC and their response to chemoradiation therapy (CRT) and to determine the implications of this overlap or lack thereof for adaptive boosting...
December 21, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29420335/any-place-left-for-induction-chemotherapy-for-locally-advanced-head-and-neck-squamous-cell-carcinoma
#17
Mickaël Burgy, Julie Leblanc, Christian Borel
The issue of induction chemotherapy (ICT) interest in locoregionally advanced squamous cell cancer of the head and neck is a real epic that has been carried out over four phase III studies: PARADIGM, DECIDE, NCT01086826 and lastly the conclusive GORTEC 2007-02. With no significant benefit in overall survival of ICT, followed by concurrent chemoradiation over the standard chemoradiotherapy alone, in three of these studies, and a significant number of treatment-related deaths with the standard regimen docetaxel, cisplatin, and fluorouracil, ICT is no longer a hot topic...
April 2018: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29362129/proportion-of-cd4-and-cd8-tumor-infiltrating-lymphocytes-predicts-survival-in-persistent-recurrent-laryngeal-squamous-cell-carcinoma
#18
Rebecca Hoesli, Andrew C Birkeland, Andrew J Rosko, Mohamad Issa, Kelsey L Chow, Nicole L Michmerhuizen, Jacqueline E Mann, Steven B Chinn, Andrew G Shuman, Mark E Prince, Gregory T Wolf, Carol R Bradford, Jonathan B McHugh, J Chad Brenner, Matthew E Spector
Tumor infiltrating lymphocytes (TILs) have been shown to be an important prognostic factor in patients with previously untreated head and neck cancer. After organ preservation therapy for laryngeal cancer and subsequent persistence/recurrence, the prognostic value of TILs is unknown. Our goal was to determine if TILs have value as a prognostic biomarker in patients with surgically salvageable persistent/recurrent laryngeal squamous cell carcinoma. Levels of TILs were quantified on tissue microarrays from 183 patients undergoing salvage total laryngectomy for persistent/recurrent laryngeal cancer after radiation or chemoradiation between 1997 and 2014...
February 2018: Oral Oncology
https://www.readbyqxmd.com/read/29362119/viable-tumor-in-salvage-neck-dissections-in-head-and-neck-cancer-relation-with-initial-treatment-change-of-lymph-node-size-and-human-papillomavirus
#19
Karlijn van den Bovenkamp, Bart Dorgelo, Maartje G Noordhuis, Bernard F A M van der Laan, Bert van der Vegt, Hendrik P Bijl, Jan L Roodenburg, Boukje A C van Dijk, Sjoukje F Oosting, Ed M D Schuuring, Johannes A Langendijk, Gyorgy B Halmos, Boudewijn E C Plaat
OBJECTIVES: To identify predictive factors for the presence of viable tumor and outcome in head and neck cancer patients who undergo therapeutic salvage neck dissections. MATERIALS AND METHODS: Retrospective analysis of 76 salvage neck dissections after radiotherapy alone (n = 22), radiotherapy in combination with carboplatin/5-fluorouracil (n = 42) or with cetuximab (n = 12). RESULTS: Viable tumor was detected in 41% of all neck dissections...
February 2018: Oral Oncology
https://www.readbyqxmd.com/read/29355901/depressive-symptoms-predict-head-and-neck-cancer-survival-examining-plausible-behavioral-and-biological-pathways
#20
Lauren A Zimmaro, Sandra E Sephton, Chelsea J Siwik, Kala M Phillips, Whitney N Rebholz, Helena C Kraemer, Janine Giese-Davis, Liz Wilson, Jeffrey M Bumpous, Elizabeth D Cash
BACKGROUND: Head and neck cancers are associated with high rates of depression, which may increase the risk for poorer immediate and long-term outcomes. Here it was hypothesized that greater depressive symptoms would predict earlier mortality, and behavioral (treatment interruption) and biological (treatment response) mediators were examined. METHODS: Patients (n = 134) reported depressive symptomatology at treatment planning. Clinical data were reviewed at the 2-year follow-up...
March 1, 2018: Cancer
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