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https://www.readbyqxmd.com/read/29419822/immunotherapy-induced-colitis-an-emerging-problem-for-the-hospitalist
#1
Julian A Marin-Acevedo, Dana M Harris, M Caroline Burton
Since their introduction for melanoma treatment, the use of immune checkpoint inhibitors (ICIs) has rapidly expanded. Though their impact on survival is irrefutable, these medications have been associated with autoimmune-like adverse events related to their ability to induce the immune system. One of the most commonly affected organ systems is the gastrointestinal (GI) tract, in which manifestations range from mild diarrhea to severe colitis with intestinal perforation. Because of the increased use of ICIs, hospitalists are caring for an increasing number of patients experiencing their adverse events...
February 6, 2018: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/29396641/-information-services-for-melanoma-patients-and-awareness-among-those-affected
#2
J Brütting, M Bergmann, C Weber, C Berking, W Tilgen, D Schadendorf, F Meier
BACKGROUND: Besides medical consultations, various sources of information and support are available for melanoma patients (MP) in Germany from commercial and non-commercial providers; however, little is known about how they are perceived and accepted by MPs. MATERIAL AND METHODS: Between July and October 2016 a total of 529 melanoma patients were surveyed at 27 accredited German skin cancer centers by means of a standardized questionnaire. Their awareness and satisfaction with 12 given sources of information and counseling services (print, online and by telephone) were surveyed...
February 2, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29384770/a-case-of-drug-induced-severe-endocrinopathies-what-providers-in-the-emergency-department-need-to-know
#3
Joshua Villarreal, David Townes, Michael Vrablik, Kumhee Ro
The purpose of this article is to present a discussion of immune checkpoint inhibitors (ICIs) that are relatively new, yet growing, form of cancer therapy. Immune checkpoint inhibitors increase host immune response against neoplastic cells. Strengthened immunological response increases the potential for adverse events such as life-threatening endocrinopathies. The case of a 66-year-old man with metastatic melanoma treated with nivolumab and ipilimumab presented to the emergency department with marked hyperglycemia and elevated anion gap 19 days after receiving both agents is discussed...
January 2018: Advanced Emergency Nursing Journal
https://www.readbyqxmd.com/read/29250474/the-most-recent-oncologic-emergency-what-emergency-physicians-need-to-know-about-the-potential-complications-of-immune-checkpoint-inhibitors
#4
REVIEW
Duncan Simmons, Eddy Lang
Immune checkpoint inhibitors targeting cytotoxic T-lymphocyte associated protein 4 (CTLA-4) and programmable cell death protein 1 (PD-1)/PD-L1 have shown antitumor activity in cancers such as melanoma, non-small cell lung cancer, renal cell carcinoma, and urothelial cancer. Certain checkpoint inhibitors have been approved for use in Canada, and are becoming a mainstay in the treatment of melanoma and other malignancies. These drugs have a unique side effect profile and are known to cause immune-related adverse events (irAEs)...
October 13, 2017: Curēus
https://www.readbyqxmd.com/read/29229575/anti-melanoma-differentiation-associated-gene-5-mda5-dermatomyositis-a-concise-review-with-an-emphasis-on-distinctive-clinical-features
#5
REVIEW
Drew Jb Kurtzman, Ruth Ann Vleugels
Melanoma differentiation-associated gene 5 (MDA5) is a recently described autoantigen target in a subset of patients with dermatomyositis (DM). Anti-MDA5 DM is characterized by a unique mucocutaneous and systemic phenotype that includes cutaneous and oral ulceration, painful palmar papules, alopecia, panniculitis, arthritis, a lower incidence of myositis, and, importantly, an elevated risk of interstitial lung disease, with a potentially fatal course. Because the clinical features may differ substantially from those typically observed in cutaneous DM, the diagnosis is often overlooked, which may negatively affect patient outcomes...
December 9, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29185439/a-survey-on-the-pattern-of-dermoscopy-use-among-dermatologists-in-india
#6
LETTER
Feroze Kaliyadan, Karalikkattil T Ashique, Soumya Jagadeesan
INTRODUCTION AND BACKGROUND: Dermoscopy is being increasingly used for improving dermatological diagnosis. Use of dermoscopy in the early recognition of skin malignancies, especially melanoma, is well established. Of late, its use in general clinical dermatology is growing with the recognition of new and specific patterns in conditions such as hair disorders, inflammatory disorders, and infections/infestations. This cross-sectional survey aims to assess the common patterns of dermoscopy use by Indian dermatologists...
January 2018: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/28752676/fine-needle-aspiration-findings-of-a-rare-hematopoietic-neoplasm-presenting-as-obstructive-jaundice
#7
Jessica Tracht, Ali M Ahmed, Frida Rosenblum Donath
A 51-year-old female who presented with obstructive jaundice was found to have masses in the pancreatic head and tail as well as suspicious liver and periaortic masses on imaging. Aspiration cytology of the pancreatic tail mass showed abundant large single cells with vacuolated eosinophilic cytoplasm, marked nuclear pleomorphism, large bizarre irregular nuclei, binucleation, and prominent nucleoli. Numerous cells also showed intracytoplasmic black to brown pigmentation. A cell block was obtained and extensive immunohistochemical staining was performed...
July 27, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28676880/innovations-and-developments-in-dermatologic-non-invasive-optical-imaging-and-potential-clinical-applications
#8
Eric Tkaczyk
Most dermatologists are aware of the benefits of dermoscopy, and a few are familiar with laser-scanning confocal microscopy. Beyond confocal, there are fully 11 different categories of optical techniques that have been applied to clinical dermatology. This article first provides a comprehensive tabular overview of all these optical diagnostic technologies and then details 4 of the lesser known innovations that are already available or still in development (laser Doppler and speckle imaging, Raman spectroscopy, multiphoton microscopy, photoacoustic tomography), with some potential applications in clinical dermatology (blood flow monitoring, skin cancer diagnosis, composition measurements in atopic dermatitis, skin rejuvenation measurement, and noninvasive sentinel lymph node assessment in melanoma)...
July 5, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28607807/immunohistochemical-evaluation-of-vitamin-d-receptor-vdr-expression-in-cutaneous-melanoma-tissues-and-four-vdr-gene-polymorphisms
#9
Francesco La Marra, Giuseppe Stinco, Cinzia Buligan, Giovanni Chiriacò, Diego Serraino, Carla Di Loreto, Sabina Cauci
OBJECTIVE: : Vitamin D receptor (VDR) mediates vitamin D activity. We examined whether VDR expression in excised melanoma tissues is associated with VDR gene (VDR) polymorphisms. METHODS: : We evaluated VDR protein expression (by monoclonal antibody immunostaining), melanoma characteristics, and carriage of VDR-FokI-rs2228570 (C>T),VDR-BsmI-rs1544410 (G>A),VDR-ApaI-rs7975232 (T>G), andVDR-TaqI-rs731236 (T>C) polymorphisms (by restriction fragment length polymorphism)...
May 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28562195/mhealth-app-for-risk-assessment-of-pigmented-and-nonpigmented-skin-lesions-a-study-on-sensitivity-and-specificity-in-detecting-malignancy
#10
Monique Thissen, Andreea Udrea, Michelle Hacking, Tanja von Braunmuehl, Thomas Ruzicka
BACKGROUND: With the advent of smartphone devices, an increasing number of mHealth applications that target melanoma identification have been developed, but none addresses the general context of melanoma and nonmelanoma skin cancer identification. INTRODUCTION: In this study a smartphone application using fractal and classical image analysis for the risk assessment of skin lesions is systematically evaluated to determine its sensitivity and specificity in the diagnosis of melanoma and nonmelanoma skin cancer along with actinic keratosis and Bowen's disease...
May 31, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28436601/management-of-skin-adverse-events-associated-with-immune-checkpoint-inhibitors-in-patients-with-melanoma-a-nursing-perspective
#11
Melissa Thebeau, Krista Rubin, Matthias Hofmann, Julia Grimm, Alyona Weinstein, Jennifer N Choi
PURPOSE: Immune checkpoint inhibitors are associated with a unique immune-related side effect profile that requires prompt recognition and management. Skin toxicities are the most common, and often earliest occurring, drug-related adverse events (AEs) of any grade observed upon treatment with these agents. The purpose of this review is to provide practical guidance on the identification and treatment of skin AEs associated with the immune checkpoint inhibitors (ipilimumab, nivolumab, and pembrolizumab) from a nursing perspective, and demonstrate hands-on application of the guidance using relevant patient case studies...
May 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/28239468/immunotherapy-associated-autoimmune-hemolytic-anemia
#12
Uqba Khan, Farman Ali, Muhammad Siddique Khurram, Awais Zaka, Tarik Hadid
BACKGROUND: Immunotherapy has been widely used in the treatment of several solid and hematologic malignancies. Checkpoint inhibitors have been the forefront of cancer immunotherapy in recent years. Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1) pathway are the prototypic checkpoint targets for immunotherapy. When combined, CTLA-4 and PD-1 checkpoint inhibitors work synergistically, but with increased probability of toxicity. The following case represents an unusual adverse effect of combined treatment with ipilimumab and nivolumab used for treatment of metastatic melanoma...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/27881937/-better-do-not-touch-and-other-superstitions-concerning-melanoma-the-cross-sectional-web-based-survey
#13
Maksymilian Gajda, Grażyna Kamińska-Winciorek, Jerzy Wydmański, Andrzej Tukiendorf
INTRODUCTION: To the authors' best knowledge, there are no data regarding the prevalence of superstitions concerning melanoma among internet users. AIM: To evaluate the prevalence and identify reasons for superstitions associated with excision of pigmented skin lesions as well as to assess the frequency of this procedure. MATERIAL AND METHODS: Readers of the scientific portal were invited to complete a fully anonymous e-questionnaire. After collection of questionnaires (5,154) and eliminating incomplete ones, 4,919 surveys were analysed...
October 2016: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/27809739/management-of-adverse-events-related-to-new-cancer-immunotherapy-immune-checkpoint-inhibitors
#14
REVIEW
Jack M Bourke, Michael O'Sullivan, Muhammad A Khattak
New immunotherapies have significantly improved survival in certain advanced cancers in recent years, particularly metastatic melanoma and lung cancer. The most effective of these therapies are the immune checkpoint inhibitors (ICIs) such as ipilimumab, nivolumab and pembrolizumab. The use of ICIs will continue to increase in the coming years as evidence of their benefit in a range of other cancers builds. ICIs are associated with novel immune-related adverse events (irAEs), which can involve a wide range of organs...
November 7, 2016: Medical Journal of Australia
https://www.readbyqxmd.com/read/27704681/tyrosine-peptides-provide-a-color-palette-upon-tyrosinase-oxidation-nanosize-does-matter
#15
Shosuke Ito, Ludger Kolbe
No abstract text is available yet for this article.
January 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/27663921/dermoscopy-of-nodular-melanoma-review-of-the-literature-and-report-of-3-cases
#16
REVIEW
Zorica Đorđević Brlek, Ružica Jurakić Tončić, Jaka Radoš, Branka Marinović
Nodular melanoma is the most aggressive subtype of melanoma, with rapid growth rate and metastatic potential. It is usually diagnosed at a locally advanced stage (Breslow thickness <2 mm) and is therefore associated with a poor prognosis. Nodular melanoma often does not fit the classic clinical ABCD criteria, but rather the EFG rule or 3 Cs criteria. Missing the diagnosis of nodular melanoma is a dermatologist's worst nightmare, especially since nodular melanomas can have a non-alarming clinical appearance and imitate a wide range of benign lesions...
August 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/27618320/tumors-and-tumorlike-conditions-of-the-anal-canal-and-perianal-region-mr-imaging-findings
#17
REVIEW
Venkateswar R Surabhi, Christine O Menias, Ahmed M Amer, Mohamed Elshikh, Venkata S Katabathina, Amy K Hara, William C Baughman, Ania Kielar, Khaled M Elsayes, Cary L Siegel
Tumors and tumorlike conditions of the anus and perianal region originate from the anal canal and anal margin or result from direct extension of tumors from adjacent organs. The anatomy of the anal canal is complex, and its different histologic characteristics can lead to diverse pathologic conditions. The anal canal extends from the anorectal junction to the anal verge. The World Health Organization classification of anal canal tumors includes (a) anal intraepithelial neoplasia, the precursor of squamous cell carcinoma (SCC), and (b) invasive tumors...
September 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27606221/does-hearing-about-cancer-influence-stimulus-control-an-exploratory-study-of-verbal-modulation-of-stimulus-generalization
#18
Thomas S Critchfield, Derek D Reed
Participants first became familiar with an image showing moderate symptoms of the skin cancer melanoma. In a generalization test, they indicated whether images showing more and less pronounced symptoms were "like the original." Some groups (cancer context) were told that the images depicted melanoma and that the disease is deadly unless detected early. Control groups were not told what the images depicted. For control groups, generalization gradients were fairly typical of what is normally reported in the generalization literature, but for cancer context groups, gradients were shifted such that highly symptomatic moles were identified as "like the original" more than normal and subtly symptomatic ones were endorsed less than normal...
June 2016: Analysis of Verbal Behavior
https://www.readbyqxmd.com/read/27583086/epidemiological-and-clinical-characteristics-of-malignant-melanoma-in-southeast-anatolia-in-turkey
#19
Bilal Sula, Feyzullah Uçmak, Mehmet Ali Kaplan, Zuhat Urakçi, Mustafa Arica, Abdurrahman Isikdogan
INTRODUCTION: The present study aimed to establish the epidemiological and clinical characteristics of patients who were histopathologically diagnosed with malignant melanoma (MM). METHODS: The present study retrospectively analyzed the data of 78 patients who were histopathologically diagnosed with MM in Dicle University Medical Faculty, Dermatology and Medical Oncology departments between 2005 and 2014. RESULTS: The study included 78 patients in total with 44 (56...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27514721/immunotherapy-of-melanoma
#20
D Kee, G McArthur
Immunotherapy for advanced melanoma has progressed dramatically in the last five years with the approval of immune checkpoint inhibitors targeting cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1). Inhibition of these targets can break cancer-immune tolerance and result in durable objective responses with significantly improved tolerability over cytokine-based immunotherapy. Ipilimumab is an inhibitor of CTLA-4 and the first-in-class immune checkpoint inhibitor to demonstrate an improvement in overall survival in melanoma...
March 2017: European Journal of Surgical Oncology
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