keyword
https://read.qxmd.com/read/38305122/the-clinico-pathological-spectrum-of-plaque-type-blue-naevi-and-their-potential-for-malignant-transformation
#1
JOURNAL ARTICLE
Calvin Tseng, Katharina Wiedemeyer, Arjun Mehta, Priscila Rojas-Garcia, Claire Temple-Oberle, Antonio Orlando, Keith Miller, Deepa Gharpuray-Pandit, Thomas Brenn
AIMS: Plaque-type blue naevi are rare melanocytic tumours presenting as large, pigmented plaques at birth or during childhood. There is a risk for malignant transformation, but no larger comprehensive studies exist and the diagnosis is challenging, especially on limited biopsy material. The aim is to describe the clinicopathological features and behaviour of the disease more comprehensively. METHODS AND RESULTS: We retrieved eight plaque-type blue naevi, presenting as large, pigmented plaques (median = 7 cm; range = 3-26) most frequently affecting the scalp (four) followed by the cheek, arm, abdominal wall and gluteal cleft (one each), with a slight female predilection...
February 2, 2024: Histopathology
https://read.qxmd.com/read/38068651/unraveling-the-potential-of-organic-oregano-and-tarragon-essential-oils-profiling-composition-ft-ir-and-bioactivities
#2
JOURNAL ARTICLE
Dan Vârban, Marius Zăhan, Ioana Crișan, Carmen Rodica Pop, Emese Gál, Răzvan Ștefan, Ancuța Mihaela Rotar, Adriana Sebastiana Muscă, Ștefania Dana Meseșan, Vasile Horga, Ioan Ladoși, Loredana Olar, Andrei Stoie, Rodica Vârban
Oregano and tarragon are widely cultivated culinary herbs used for food seasoning, having familiar characteristic aromas appreciated by the wide public. The aim of this research was to characterize essential oils (EOs) from locally sourced organic oregano and tarragon (Cluj, Romania) and study their bioactivity potential. Results showed that oregano EO had a sesquiterpene dominant profile responsible for strong bands between 2800 and 3000 cm-1 on the Fourier transform infrared spectroscopy (FT-IR) spectrum and a composition consistent with reports from similar climatic regions...
November 29, 2023: Plants (Basel, Switzerland)
https://read.qxmd.com/read/38032822/skin-malignancies-imaging-review-with-radiologic-histopathologic-correlation
#3
JOURNAL ARTICLE
Priya Pathak, Bitania Wondimu, Rozita Jalilianhasanpour, Atefe Pooyan, Manuela C Matesan, Bahar Mansoori
Skin malignancies are commonly encountered as primary or incidental findings. Neoplasms that affect the skin include primary (basal cell carcinoma, squamous cell carcinoma, melanoma, and Merkel cell carcinoma) and secondary (mesenchymal neoplasms, lymphoma, and metastases) tumors. Imaging provides valuable anatomic information (tumor size, depth of involvement, presence of distant metastasis, and data for guiding biopsy) and functional information (metabolic activity and sentinel node mapping data). This information, in addition to biopsy results, improves the histopathologic characterization of tumors and treatment planning...
December 2023: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://read.qxmd.com/read/37777382/reflectance-confocal-microscopy-consensus-terminology-glossary-in-brazilian-portuguese-for-normal-skin-melanocytic-and-non-melanocytic-lesions
#4
JOURNAL ARTICLE
Juliana Casagrande Tavoloni Braga, Carlos B Barcaui, Ana Maria Pinheiro, Ana Maria Fagundes Sortino, Cristina Martinez Zugaib Abdalla, Gabriella Campos-do-Carmo, Gisele Gargantini Rezze, Juan Piñeiro-Maceira, Lilian Licarião Rocha, Marcus Maia, Bianca Costa Soares de Sá
BACKGROUND: Currently, there is no uniform and official terminology in Portuguese for reflectance confocal microscopy analysis, despite the increasing number of Brazilian dermatologists using this new tool. OBJECTIVE: To present the terminology in Brazilian Portuguese for the description of reflectance confocal microscopy and establish the first Brazilian consensus on terms related to normal skin and cutaneous tumors. METHODS: 10 Brazilian specialists from different institutions and states of Brazil were selected to evaluate the best corresponding terms in Portuguese for normal skin, melanocytic and non-melanocytic tumors...
September 28, 2023: Anais Brasileiros de Dermatologia
https://read.qxmd.com/read/37763236/clinical-and-dermoscopic-findings-of-nevi-after-photoepilation-a-review
#5
REVIEW
Clio Dessinioti, Andriani Tsiakou, Athina Christodoulou, Alexander J Stratigos
Atypical clinical and dermoscopic findings, or changes in pigmented melanocytic lesions located on body areas treated with lasers or intense pulsed light (IPL) for hair removal (photoepilation), have been described in the literature. There are three prospective studies in a total of 79 individuals with 287 melanocytic nevi and several case reports reporting the dermoscopic findings and changes after photoepilation. Clinical changes have been reported in 20-100% of individuals, while dermoscopic changes have been observed in 48% to 93% of nevi...
August 29, 2023: Life
https://read.qxmd.com/read/37643240/perianal-malignancies-a-review-for-the-dermatologic-surgeon
#6
JOURNAL ARTICLE
Cory Kosche, Anthony M Rossi
BACKGROUND: Perianal malignancies are rare tumors with unique presentations and treatment options. OBJECTIVE: To review published literature about primary malignancies that present on perianal skin and published guidelines and treatment options. MATERIALS AND METHODS: A PubMed search was conducted for original articles about perianal malignancies. RESULTS: Squamous cell carcinoma, basal cell carcinoma, melanoma, and extramammary Paget disease are the most common tumors to present on perianal skin...
August 29, 2023: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://read.qxmd.com/read/37239385/hereditary-cancer-syndromes-a-comprehensive-review-with-a-visual-tool
#7
REVIEW
Mattia Garutti, Lorenzo Foffano, Roberta Mazzeo, Anna Michelotti, Lucia Da Ros, Alessandra Viel, Gianmaria Miolo, Alberto Zambelli, Fabio Puglisi
Hereditary cancer syndromes account for nearly 10% of cancers even though they are often underdiagnosed. Finding a pathogenic gene variant could have dramatic implications in terms of pharmacologic treatments, tailored preventive programs, and familiar cascade testing. However, diagnosing a hereditary cancer syndrome could be challenging because of a lack of validated testing criteria or because of their suboptimal performance. In addition, many clinicians are not sufficiently well trained to identify and select patients that could benefit from a genetic test...
April 30, 2023: Genes
https://read.qxmd.com/read/37203903/primary-anorectal-melanoma-a-case-report
#8
JOURNAL ARTICLE
Sajjad Ahmed Khan, Adarsha Neupane, Samit Kumar Gautam, Sulav Sapkota
UNLABELLED: Primary anorectal melanoma is an extremely rare and aggressive mucosal melanocytic malignancy of the anorectal region. Because of the rarity of the tumor and vague clinical presentations, diagnosis at an early stage is a challenge for clinicians. In our context, where the hemorrhoid is a diagnosis of cultural familiarity for any sort of rectal pathology, these patients often present to us at a very advanced stage of the disease. Here, we present a case of a 55-year-old male patient with stage 2 anorectal melanoma who is on adjuvant chemotherapy following abdominoperineal resection with a permanent colostomy...
May 1, 2023: JNMA; Journal of the Nepal Medical Association
https://read.qxmd.com/read/37174716/rethinking-oncologic-treatment-strategies-with-interleukin-2
#9
REVIEW
Brian Ko, Naoko Takebe, Omozusi Andrews, Monish Ram Makena, Alice P Chen
High-dose recombinant human IL-2 (rhIL-2, aldesleukin) emerged as an important treatment option for selected patients with metastatic melanoma and metastatic renal cell carcinoma, producing durable and long-lasting antitumor responses in a small fraction of patients and heralding the potential of cancer immunotherapy. However, the adoption of high-dose rhIL-2 has been restricted by its severe treatment-related adverse event (TRAE) profile, which necessitates highly experienced clinical providers familiar with rhIL-2 administration and readily accessible critical care medicine support...
May 5, 2023: Cells
https://read.qxmd.com/read/37144178/implementing-the-melanocytic-pathology-assessment-tool-and-hierarchy-for-diagnosis-long-term-effect-of-a-simple-educational-intervention
#10
JOURNAL ARTICLE
Lisa M Reisch, Hannah Shucard, Andrea C Radick, Megan M Eguchi, David E Elder, Raymond L Barnhill, Michael W Piepkorn, Stevan R Knezevich, Kathleen F Kerr, Joann G Elmore
BACKGROUND: A standardized pathology management tool for melanocytic skin lesions may improve patient care by simplifying interpretation and categorization of the diverse terminology currently extant. OBJECTIVE: To assess an online educational intervention that teaches dermatopathologists to use the Melanocytic Pathology Assessment Tool and Hierarchy for Diagnosis (MPATH-Dx), a schema collapsing multiple diagnostic terms into 5 classes ranging from benign to invasive melanoma...
June 2023: JAAD international
https://read.qxmd.com/read/37027015/beyond-squamous-cell-carcinoma-mri-appearance-of-uncommon-anal-neoplasms-and-mimickers
#11
REVIEW
Maria El Homsi, Jennifer S Golia Pernicka, Chandana Lall, Stephanie Nougaret, Raj M Paspulati, Perry J Pickhardt, Shannon P Sheedy, Iva Petkovska
Anal cancer is an uncommon malignancy. In addition to squamous cell carcinoma, there are a variety of other less common malignancies and benign pathologies that may afflict the anal canal, with which abdominal radiologists should be familiar. Abdominal radiologists should be familiar with the imaging features that can help distinguish different rare anal tumors beyond squamous cell carcinoma and that can aid in diagnosis therefore help steer management. This review discusses these uncommon pathologies with a focus on their imaging appearance, management, and prognosis...
April 7, 2023: Abdominal Radiology
https://read.qxmd.com/read/36980308/adult-and-pediatric-nail-unit-melanoma-epidemiology-diagnosis-and-treatment
#12
REVIEW
Jade Conway, Jane S Bellet, Adam I Rubin, Shari R Lipner
Nail unit melanoma (NUM) is an uncommon form of melanoma and is often diagnosed at later stages. Approximately two-thirds of NUMs are present clinically as longitudinal melanonychia, but longitudinal melanonychia has a broad differential diagnosis. Clinical examination and dermoscopy are valuable for identifying nail findings concerning malignancy, but a biopsy with histopathology is necessary to confirm a diagnosis of NUM. Surgical treatment options for NUM include en bloc excision, digit amputation, and Mohs micrographic surgery...
March 22, 2023: Cells
https://read.qxmd.com/read/36973713/oncological-healthcare-providers-perspectives-on-appropriate-melanoma-survivorship-care-a-qualitative-focus-group-study
#13
JOURNAL ARTICLE
Nadia C W Kamminga, Marlies Wakkee, Rianne J De Bruin, Astrid A M van der Veldt, Arjen Joosse, Suzan W I Reeder, Peter W Plaisier, Tamar Nijsten, Marjolein Lugtenberg
BACKGROUND: The increasing group of melanoma survivors reports multiple unmet needs regarding survivorship care (SSC). To optimise melanoma SSC, it is crucial to take into account the perspectives of oncological healthcare providers (HCPs) in addition to those of patients. The aim of this study is to gain an in-depth understanding of HCPs' perspectives on appropriate melanoma SSC. METHODS: Four online focus groups were conducted with mixed samples of oncological HCPs (dermatologists, surgeons, oncologists, oncological nurse practitioners, support counsellors and general practitioners) (total n = 23)...
March 28, 2023: BMC Cancer
https://read.qxmd.com/read/36902697/challenges-in-the-complex-management-of-neglected-cutaneous-melanomas-in-the-head-and-neck-area-a-single-center-experience
#14
JOURNAL ARTICLE
Péter Lázár, Edit Tóth Molnár, Balázs Bende, Gábor Vass, Eszter Baltás, Róbert Paczona, Erika Varga, József Piffkó, Lajos Kemény, Judit Oláh, Erika Gabriella Kis
Familiar controversies in the management of head and neck melanomas are more remarkable in locally advanced cases, and they represent a treatment challenge both surgically and oncologically. In our retrospective study, patients with surgically treated primary malignant melanoma of the head and neck region larger than 3 cm in diameter were included. Five patients met our inclusion criteria. In all cases, wide excision and immediate reconstruction were performed without sentinel lymph node biopsy. The defect on the scalp was covered by a split skin graft, with local flaps chosen for reconstruction on the face on an individual basis...
February 28, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/36855886/the-future-of-cancer-immunotherapy
#15
JOURNAL ARTICLE
Nicolas Mach
<b/>This article describes three emerging, novel cancer immunotherapies: BITE, TIL and cancer vaccines are therapies that recognize specific targets on cancer cells and trigger a specific immune response. So far, not all tumor types can benefit from these approaches the best results have been observed in hematological malignancies, melanoma, and lung cancer. These novel biological products are currently being tested in several cancer centers in Switzerland, and physicians must be familiar with these procedures, as some of their patients might be treated with such therapies in the near future...
2023: Praxis
https://read.qxmd.com/read/36433634/melanoma-awareness-and-prevention-among-latinx-and-non-latinx-white-adults-in-urban-and-rural-california-a-qualitative-exploration
#16
JOURNAL ARTICLE
Rachel J Mesia, Patricia Rodriguez Espinosa, Hayden Hutchison, Nadia Safaeinili, Laurel J Finster, Vijaytha Muralidharan, Beth A Glenn, Robert W Haile, Lisa Goldman Rosas, Susan M Swetter
BACKGROUND: Melanoma mortality rates in the US are highest among older men, individuals of lower socioeconomic status (SES), and people of color. To better understand these inequities, a qualitative exploratory study was conducted in Northern and Southern California to generate knowledge about barriers and facilitators of awareness, prevention, and early detection of melanoma in lower SES Latinx and non-Latinx White (NLW) individuals living in urban and semi-rural areas. METHODS: Nineteen focus groups were conducted (N = 176 adult participants), stratified by race/ethnicity (Latinx, low-income NLW), geography (semi-rural, urban), and language (English and Spanish)...
November 25, 2022: Cancer Medicine
https://read.qxmd.com/read/36300431/-nail-disorders-in-daily-practice
#17
JOURNAL ARTICLE
Charlotte R M Hetterschijt, Marcel C Pasch
Familiarity with common nail disorders enables the clinician to diagnose and treat nail disorders and to recognize red-flag conditions. Knowledge of the anatomy of the nail unit is essential to understand the origin of nail disorders. This article focuses on neoplasms, abnormalities of nail color and shape, infections, and inflammatory conditions of the nail unit. There are various neoplasms of and around the nail unit, like squamous cell carcinoma (in situ), melanoma, and benign neoplasms such as mucous cyst, subungual exostosis, glomus tumor, onychopapilloma and fibro(kerato)ma...
September 8, 2022: Nederlands Tijdschrift Voor Geneeskunde
https://read.qxmd.com/read/36159145/an-updated-algorithm-integrated-with-patient-data-for-the-differentiation-of-atypical-nevi-from-early-melanomas-the-idscore-2021
#18
JOURNAL ARTICLE
Linda Tognetti, Alessandra Cartocci, Martina Bertello, Mafalda Giordani, Elisa Cinotti, Gabriele Cevenini, Pietro Rubegni
Introduction: It is well known that multiple patient-related risk factors contribute to the development of cutaneous melanoma, including demographic, phenotypic and anamnestic factors. Objectives: We aimed to investigate which MM risk factors were relevant to be incorporated in a risk scoring-classifier based clinico-dermoscopic algorithm. Methods: This retrospective study was performed on a monocentric dataset of 374 atypical melanocytic skin lesions sharing equivocal dermoscopic features, excised in the suspicion of malignancy...
July 2022: Dermatology Practical & Conceptual
https://read.qxmd.com/read/36063001/combining-reflectance-confocal-microscopy-with-optical-coherence-tomography-for-noninvasive-diagnosis-of-skin-cancers-via-image-acquisition
#19
JOURNAL ARTICLE
Ucalene Harris, Milind Rajadhyaksha, Manu Jain
Skin cancer is one of the most common cancers worldwide. Diagnosis relies on visual inspection and dermoscopy followed by biopsy for histopathological confirmation. While the sensitivity of dermoscopy is high, the lower specificity results in 70%-80% of the biopsies being diagnosed as benign lesions on histopathology (false positives on dermoscopy). Reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) imaging can noninvasively guide the diagnosis of skin cancers. RCM visualizes cellular morphology in en-face layers...
August 18, 2022: Journal of Visualized Experiments: JoVE
https://read.qxmd.com/read/35942012/racial-and-ethnic-healthcare-disparities-in-skin-cancer-in-the-united-states-a-review-of-existing-inequities-contributing-factors-and-potential-solutions
#20
REVIEW
Kimberly Shao, Hao Feng
Objective: Racial and ethnic health disparities affect the diagnosis and management of melanoma and nonmelanoma skin cancers, leading to deleterious outcomes. Non-Hispanic White patients make up the majority of skin cancers cases, yet racial and ethnic minorities have poorer prognoses and outcomes. The skin cancer literature is fragmented with regards to potential contributors to these healthcare disparities. In this article, we provide a comprehensive review of the skin cancer literature to briefly quantify racial and ethnic inequities, highlight contributing factors, and propose practical changes that can be made...
July 2022: Journal of Clinical and Aesthetic Dermatology
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