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Anesthesia electrophysiology hippocampus

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https://www.readbyqxmd.com/read/27648470/vta-projection-neurons-releasing-gaba-and-glutamate-in-the-dentate-gyrus
#1
Niels R Ntamati, Christian Lüscher
Both dopamine and nondopamine neurons from the ventral tegmental area (VTA) project to a variety of brain regions. Here we examine nondopaminergic neurons in the mouse VTA that send long-range projections to the hippocampus. Using a combination of retrograde tracers, optogenetic tools, and electrophysiological recordings, we show that VTA GABAergic axons make synaptic contacts in the granule cell layer of the dentate gyrus, where we can elicit small postsynaptic currents. Surprisingly, the currents displayed a partial sensitivity to both bicuculline and NBQX, suggesting that these mesohippocampal neurons corelease both GABA and glutamate...
July 2016: ENeuro
https://www.readbyqxmd.com/read/26612208/learning-memory-and-synaptic-plasticity-in-hippocampus-in-rats-exposed-to-sevoflurane
#2
Hongyan Xiao, Bing Liu, Yali Chen, Jun Zhang
PURPOSE: Developmental exposure to volatile anesthetics has been associated with cognitive deficits at adulthood. Rodent studies have revealed impairments in performance in learning tasks involving the hippocampus. However, how the duration of anesthesia exposure impact on hippocampal synaptic plasticity, learning, and memory is as yet not fully elucidated. METHODS: On postnatal day 7(P7), rat pups were divided into 3 groups: control group (n=30), 3% sevoflurane treatment for 1h (Sev 1h group, n=30) and 3% sevoflurane treatment for 6h (Sev 6h group, n=28)...
February 2016: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/25429118/sensing-enabled-hippocampal-deep-brain-stimulation-in-idiopathic-nonhuman-primate-epilepsy
#3
W J Lipski, V J DeStefino, S R Stanslaski, A R Antony, D J Crammond, J L Cameron, R M Richardson
Epilepsy is a debilitating condition affecting 1% of the population worldwide. Medications fail to control seizures in at least 30% of patients, and deep brain stimulation (DBS) is a promising alternative treatment. A modified clinical DBS hardware platform was recently described (PC+S) allowing long-term recording of electrical brain activity such that effects of DBS on neural networks can be examined. This study reports the first use of this device to characterize idiopathic epilepsy and assess the effects of stimulation in a nonhuman primate (NHP)...
February 15, 2015: Journal of Neurophysiology
https://www.readbyqxmd.com/read/23172213/hippocampal-cortical-interaction-during-periods-of-subcortical-silence
#4
N K Logothetis, O Eschenko, Y Murayama, M Augath, T Steudel, H C Evrard, M Besserve, A Oeltermann
Hippocampal ripples, episodic high-frequency field-potential oscillations primarily occurring during sleep and calmness, have been described in mice, rats, rabbits, monkeys and humans, and so far they have been associated with retention of previously acquired awake experience. Although hippocampal ripples have been studied in detail using neurophysiological methods, the global effects of ripples on the entire brain remain elusive, primarily owing to a lack of methodologies permitting concurrent hippocampal recordings and whole-brain activity mapping...
November 22, 2012: Nature
https://www.readbyqxmd.com/read/21331565/effects-of-developmental-exposure-to-tio2-nanoparticles-on-synaptic-plasticity-in-hippocampal-dentate-gyrus-area-an-in-vivo-study-in-anesthetized-rats
#5
Xiaoyan Gao, Shuting Yin, Mingliang Tang, Jutao Chen, Zhongfei Yang, Wencai Zhang, Liang Chen, Bo Yang, Zhifeng Li, Yingying Zha, Diyun Ruan, Ming Wang
With the increasing applications of titanium dioxide nanoparticles (TiO(2) NPs) in industry and daily life, an increasing number of studies showed that TiO(2) NPs may have negative effects on the respiratory or metabolic circle systems of organisms, while very few studies focused on the brain central nervous system (CNS). Synaptic plasticity in hippocampus is believed to be associated with certain high functions of CNS, such as learning and memory. Thus, in this study, we investigated the effects of developmental exposure to TiO(2) NPs on synaptic plasticity in rats' hippocampal dentate gyrus (DG) area using in vivo electrophysiological recordings...
December 2011: Biological Trace Element Research
https://www.readbyqxmd.com/read/21165147/temporal-dynamics-of-distinct-ca1-cell-populations-during-unconscious-state-induced-by-ketamine
#6
Hui Kuang, Longnian Lin, Joe Z Tsien
Ketamine is a widely used dissociative anesthetic which can induce some psychotic-like symptoms and memory deficits in some patients during the post-operative period. To understand its effects on neural population dynamics in the brain, we employed large-scale in vivo ensemble recording techniques to monitor the activity patterns of simultaneously recorded hippocampal CA1 pyramidal cells and various interneurons during several conscious and unconscious states such as awake rest, running, slow wave sleep, and ketamine-induced anesthesia...
2010: PloS One
https://www.readbyqxmd.com/read/20927045/disrupted-activity-in-the-hippocampal-accumbens-circuit-of-type-iii-neuregulin-1-mutant-mice
#7
Malcolm W Nason, Avishek Adhikari, Marjan Bozinoski, Joshua A Gordon, Lorna W Role
Neuregulin 1 (Nrg1), a schizophrenia susceptibility gene, is involved in fundamental aspects of neurodevelopment. Mice lacking any one of the several isoforms of Nrg1 have a variety of schizophrenia-related phenotypes, including deficits in working memory and sensorimotor gating, loss of spines in pyramidal neurons in the ventral subiculum, loss of dendrites in cortical pyramidal cells, loss of parvalbumin-positive interneurons in the prefrontal cortex, and altered plasticity in corticolimbic synapses. Mice heterozygous for a disruption in exon 7 of the Nrg1 gene lack Type III (cysteine-rich-domain-containing) isoforms and have sensorimotor gating deficits that may involve changes in the activity of a circuit involving projections from the ventral hippocampus (vHPC) to medium spiny neurons in the nucleus accumbens (nACC)...
January 2011: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/20508498/activity-patterns-in-the-prefrontal-cortex-and-hippocampus-during-and-after-awakening-from-etomidate-anesthesia
#8
Sergejus Butovas, Uwe Rudolph, Rachel Jurd, Cornelius Schwarz, Bernd Antkowiak
BACKGROUND: The anesthetic properties of etomidate are largely mediated by gamma-aminobutyric acid type A receptors. There is evidence for the existence of gamma-aminobutyric acid type A receptor subtypes in the brain, which respond to small concentrations of etomidate. After awakening from anesthesia, these subtypes are expected to cause cognitive dysfunction for a yet unknown period of time. The corresponding patterns of brain electrical activity and the molecular identity of gamma-aminobutyric acid type A receptors contributing to these actions remain to be elucidated...
July 2010: Anesthesiology
https://www.readbyqxmd.com/read/20463202/minor-contribution-of-principal-excitatory-pathways-to-hippocampal-lfps-in-the-anesthetized-rat-a-combined-independent-component-and-current-source-density-study
#9
A Korovaichuk, J Makarova, V A Makarov, N Benito, O Herreras
Analysis of local field potentials (LFPs) helps understand the function of the converging neuronal populations that produce the mixed synaptic activity in principal cells. Recently, using independent component analysis (ICA), we resolved ongoing hippocampal activity into several major contributions of stratified LFP-generators. Here, using pathway-specific LFP reconstruction, we isolated LFP-generators that describe the activity of Schaffer-CA1 and Perforant-Dentate excitatory inputs in the anesthetized rat...
July 2010: Journal of Neurophysiology
https://www.readbyqxmd.com/read/20435940/presynaptic-actions-of-general-anesthetics-are-responsible-for-frequency-dependent-modification-of-synaptic-transmission-in-the-rat-hippocampal-ca1
#10
Koki Hirota, Rika Sasaki, Sheldon H Roth, Mitsuaki Yamazaki
BACKGROUND: In clinical anesthesia, robust surgical stress occasionally causes unintended light anesthesia during operation. To test the hypothesis that neural input condition could modify actions of general anesthetics as a result of presynaptic alteration in the central nervous system, we investigated the mechanisms by which the stimulus frequency modifies synaptic transmission of the rat hippocampus in the presence of general anesthetics. METHODS: Field population spikes (PSs) of CA1 pyramidal neurons were elicited using orthodromic stimulation of Schaffer collateral-commissural fibers (test-pulse)...
June 1, 2010: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/20418293/isoflurane-anesthesia-does-not-satisfy-the-homeostatic-need-for-rapid-eye-movement-sleep
#11
George A Mashour, William J Lipinski, Lisa B Matlen, Amanda J Walker, Ashley M Turner, Walter Schoen, Uncheol Lee, Gina R Poe
BACKGROUND: Sleep and general anesthesia are distinct states of consciousness that share many traits. Prior studies suggest that propofol anesthesia facilitates recovery from rapid eye movement (REM) and non-REM (NREM) sleep deprivation, but the effects of inhaled anesthetics have not yet been studied. We tested the hypothesis that isoflurane anesthesia would also facilitate recovery from REM sleep deprivation. METHODS: Six rats were implanted with superficial cortical, deep hippocampal, and nuchal muscle electrodes...
May 1, 2010: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/20204395/assessing-cortico-hippocampal-functional-connectivity-under-anesthesia-and-kainic-acid-using-generalized-partial-directed-coherence
#12
Jiannis Taxidis, Ben Coomber, Rob Mason, Markus Owen
A significant challenge in modern neuroscience lies in determining the functional connectivity between discrete populations of neurones and brain regions. In this study, a variation of partial directed coherence, the generalized partial directed coherence (gPDC), along with a newly proposed critical value for gPDC, were applied on recorded local field potentials (LFPs) and single-unit activity, in order to assess information flow between medial prefrontal cortex (mPFC) and hippocampus and within the hippocampus of the rat brain, under isoflurane anesthesia and kainic acid-induced enhanced neuronal activity...
April 2010: Biological Cybernetics
https://www.readbyqxmd.com/read/19568478/enhancement-of-the-function-of-rat-serotonin-and-norepinephrine-neurons-by-sustained-vagus-nerve-stimulation
#13
Stella Manta, Jianming Dong, Guy Debonnel, Pierre Blier
BACKGROUND: Vagus nerve stimulation (VNS) is a recent intervention for treatment-resistant depression. Electrophysiological recordings in the rat brain showed that VNS increases the firing rate of norepinephrine (NE) neurons after 1 day of stimulation and that of serotonin (5-HT) neurons after 14 days. This study was conducted to further characterize these effects. METHODS: We implanted rats with a VNS electrode and stimulator. We used the selective noradrenergic toxin DSP-4 to lesion NE neurons of the locus coeruleus...
July 2009: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/19412934/hippocampal-injury-atrophy-synaptic-reorganization-and-epileptogenesis-after-perforant-pathway-stimulation-induced-status-epilepticus-in-the-mouse
#14
Friederike Kienzler, Braxton A Norwood, Robert S Sloviter
Prolonged dentate granule cell discharges produce hippocampal injury and chronic epilepsy in rats. In preparing to study this epileptogenic process in genetically altered mice, we determined whether the background strain used to generate most genetically altered mice, the C57BL/6 mouse, is vulnerable to stimulation-induced seizure-induced injury. This was necessary because C57BL/6 mice are reportedly resistant to the neurotoxic effects of kainate-induced seizures, which we hypothesized to be related to strain differences in kainate's effects, rather than genetic differences in intrinsic neuronal vulnerability...
July 10, 2009: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/19058511/effects-of-isoflurane-on-hippocampal-seizures-at-immature-rats-in-vivo
#15
E V Isaeva
In the present study we examined the effect of isoflurane on seizure-like activity at hippocampal CA3 pyramidal region of immature rats in vivo. We found that isoflurane in clinically relevant concentrations effectively stops hippocampal seizures. When animal was under isoflurane anesthesia seizure-like activity still can be evoked by application of proconvulstant agents, but this activity was qualitatively different from that obtained in nonanesthetized rats. This observation suggests that the mechanism by which seizures are terminated differ from the mechanism responsible for preventing of the initiation of seizures...
2008: Fiziolohichnyĭ Zhurnal
https://www.readbyqxmd.com/read/17525592/amnesic-concentrations-of-the-nonimmobilizer-1-2-dichlorohexafluorocyclobutane-f6-2n-and-isoflurane-alter-hippocampal-theta-oscillations-in-vivo
#16
Misha Perouansky, Harald Hentschke, Mark Perkins, Robert A Pearce
BACKGROUND: Drug-induced temporary amnesia is one of the principal goals of general anesthesia. The nonimmobilizer 1,2-dichlorohexafluorocyclobutane (F6, also termed 2N) impairs hippocampus-dependent learning at relative, i.e., lipophilicity-corrected, concentrations similar to isoflurane. Hippocampal theta oscillations facilitate mnemonic processes in vivo and synaptic plasticity (a cellular model of memory) in vitro and are thought to represent a circuit level phenomenon that supports memory encoding...
June 2007: Anesthesiology
https://www.readbyqxmd.com/read/17179597/-effects-of-ultracaine-on-the-local-blood-flow-of-the-gum-and-on-the-development-of-cerebral-seizures-in-experiment
#17
N A Tsilosani, N P Mitagvariia, M G Devdariani, I G Bilanishvili, Z I Nanobashvili
We have studied the effect of ultracaine DS forte on local blood flow of the rat gum as well as on the development of the convulsion activity of the brain at systemic injection. Experiments were carried out on 12 mongrel albino mail rats of 200-250 g weight. In the I group of animals under the light chloral hydrate anesthesia we studied the changes of local blood flow in the rat gum of lower jaw after ultracaine DS forte injection (right side) and the similar quantity of phisiological solution (left side). According to our data, in the right gum, the rate of local blood flow decreases statistically significantly at 18%, while the injection of physiological solution did not result in any changes...
November 2006: Georgian Medical News
https://www.readbyqxmd.com/read/17145507/integration-and-segregation-of-activity-in-entorhinal-hippocampal-subregions-by-neocortical-slow-oscillations
#18
Yoshikazu Isomura, Anton Sirota, Simal Ozen, Sean Montgomery, Kenji Mizuseki, Darrell A Henze, György Buzsáki
Brain systems communicate by means of neuronal oscillations at multiple temporal and spatial scales. In anesthetized rats, we find that neocortical "slow" oscillation engages neurons in prefrontal, somatosensory, entorhinal, and subicular cortices into synchronous transitions between UP and DOWN states, with a corresponding bimodal distribution of their membrane potential. The membrane potential of hippocampal granule cells and CA3 and CA1 pyramidal cells lacked bimodality, yet it was influenced by the slow oscillation in a region-specific manner...
December 7, 2006: Neuron
https://www.readbyqxmd.com/read/17027251/flexible-polyimide-microelectrode-array-for-in-vivo-recordings-and-current-source-density-analysis
#19
Karen C Cheung, Philippe Renaud, Heikki Tanila, Kaj Djupsund
This work presents implantable, flexible polymer-based probes with embedded microelectrodes for acute and chronic neural recordings in vivo, as tested on rodents. Acute recordings using this array were done in mice under urethane anesthesia and compared to those made using silicon-based probes manufactured at the Center for Neural Communication Technology, University of Michigan. The two electrode arrays yielded similar results. Recordings with chronically implanted polymer-based electrodes were performed for 60 days post-surgically in awake, behaving rats...
March 15, 2007: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/16943562/firing-properties-of-anatomically-identified-neurons-in-the-medial-septum-of-anesthetized-and-unanesthetized-restrained-rats
#20
Axelle Pascale Simon, Frédérique Poindessous-Jazat, Patrick Dutar, Jacques Epelbaum, Marie-Hélène Bassant
Cholinergic and GABAergic neurons in the medial septum-diagonal band of Broca (MS-DB) project to the hippocampus where they are involved in generating theta rhythmicity. So far, the functional properties of neurochemically identified MS-DB neurons are not fully characterized. In this study, MS-DB neurons recorded in urethane anesthetized rats and in unanesthetized restrained rats were labeled with neurobiotin and processed for immunohistochemistry against glutamic acid decarboxylase (GAD), parvalbumin (PV), and choline acetyltransferase (ChAT)...
August 30, 2006: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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