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https://www.readbyqxmd.com/read/28239898/early-signal-of-diverted-use-of-tropicamide-eye-drops-in-france
#1
Camille Ponté, Christian Pi, Aurore Palmaro, Emilie Jouanjus, Maryse Lapeyre-Mestre
BACKGROUND: Tropicamide is a mydriatic drug used as eye-drops for diagnostic or therapeutic purposes. From 2013, a diverted use by intravenous route has been suspected in Eastern Europe in opioids users. To recent date, no signal of a misuse has been identified in France. PURPOSE: To investigate an early signal of a diverted use of tropicamide eye drops and to collect information regarding motives of misusing and tropicamide-induced effects. METHODS: Information was obtained at 1/ regional level (Midi-Pyrénées area): reimbursement data and pharmacists' reports on suspicious requests, 2/ national level: reimbursement data and prescriptions suggesting possible abuse from the OSIAP (Ordonnances Suspectes, Indicateur d'Abus Possible) survey and 3/ international level: VigiBase® reports and Web sources...
February 27, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28238918/zenith-bifurcated-iliac-side-branch-device-mid-term-results-and-assessment-of-risk-factors-for-intraoperative-thrombosis
#2
Charline Delay, Sébastien Deglise, Anne Lejay, Yannick Georg, Mathieu Roussin, Mickaël Schaeffer, François Saucy, Fabien Thaveau, Jean-Marc Corpataux, Nabil Chakfe
INTRODUCTION: The aim of this study was to evaluate the short- and mid-term results of the Zenith bifurcated iliac side branch device (ZBIS) in the treatment of common iliac artery (CIA) aneurysms, and to assess risk factors for intraoperative internal iliac artery (IIA) thrombosis. MATERIALS AND METHODS: All patients who underwent endovascular treatment of either an isolated CIA aneurysm or an aorto-iliac aneurysm using the ZBIS device in the departments of vascular surgery of Strasbourg (France) and Lausanne (Switzerland) between January 2010 and December 2014 were retrospectively collected...
February 23, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28238476/socioeconomic-inequalities-to-accessing-vaccination-against-human-papillomavirus-in-france-results-of-the-health-health-care-and-insurance-survey-2012
#3
J-P Guthmann, C Pelat, N Célant, I Parent du Chatelet, N Duport, T Rochereau, D Lévy-Bruhl
BACKGROUND: In France, human papillomavirus (HPV) vaccination coverage among adolescents and young women is low and decreasing. We analysed data from the 2012 Health, Health Care and Insurance Survey with the aim of identifying factors associated with this vaccination. We also compared the socioeconomic profile of unvaccinated young women to that of women who do not undergo cervical cancer screening (CCS). METHODS: Data were collected through interviews and self-administered questionnaires completed by a randomised sample of Health insurance beneficiaries...
February 23, 2017: Revue D'épidémiologie et de Santé Publique
https://www.readbyqxmd.com/read/28238310/-repeat-induced-abortion-a-multicenter-study-on-medical-abortions-in-france-in-2014
#4
M Opatowski, F Bardy, P David, A Dunbavand, M-J Saurel-Cubizolles
OBJECTIVES: To describe the social characteristics of women seeking a medical abortion, and the conditions of that abortion, according to whether they had one or more previous induced abortions. METHODS: An observational study was carried out in 11 French units in 2013-2014, among women 18 years or older. A self-administered questionnaire on the abortion context and social situation was given to them, as well as a diary to record the pain level for each of five days following the mifepristone intake...
January 2017: Gynecol Obstet Fertil Senol
https://www.readbyqxmd.com/read/28238172/local-versus-landscape-spatial-influence-on-biodiversity-a-case-study-across-five-european-industrialized-areas
#5
E Piano, M Isaia, E Falasco, V La Morgia, G Soldato, F Bona
Land use change-mostly habitat loss and fragmentation-has been recognized as one of the major drivers of biodiversity loss worldwide. According to the habitat amount hypothesis, these phenomena are mostly driven by the habitat area effect. As a result, species richness is a function of both the extent of suitable habitats and their availability in the surrounding landscape, irrespective of the dimension and isolation of patches of suitable habitat. In this context, we tested how the extent of natural areas, selected as proxies of suitable habitats for biodiversity, influences species richness in highly anthropogenic landscapes...
March 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28238138/dual-wavelength-triggered-gold-nanorods-for-anticancer-treatment
#6
Dennis B Pacardo, Frances S Ligler, Zhen Gu
Gold nanomaterials with light-responsive properties can be exploited as light-triggered delivery vehicles to enhance the therapeutic efficacy of anticancer drugs. Additionally, different wavelengths of light can be utilized to achieve the combined effects of light-triggered release of therapeutics and light-induced localized heating, which results in improved anticancer efficacy. Herein, we describe methods to develop gold nanorod (AuNR) complexes that provide drug delivery or photothermal therapy when activated by ultraviolet (UV) or near-infrared (NIR) wavelengths of light, respectively...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28237957/performance-curves-of-medical-researchers-during-their-career-analysis-of-scientific-production-from-a-retrospective-cohort
#7
Antoine Duclos, Eléonore Herquelot, Stéphanie Polazzi, Muriel Malbezin, Olivier Claris
OBJECTIVES: To establish the pattern of change in individual scientific production over the career of medical researchers. DESIGN: Retrospective cohort based on prospectively collected data in a hospital information system. SETTING: Multicentre university hospital in France. PARTICIPANTS: Two distinct populations of 1835 researchers (full professors vs non-academic physicians) having produced 44 723 publications between 1995 and 2014...
February 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28237955/advance-care-planning-uptake-among-patients-with-severe-lung-disease-a-randomised-patient-preference-trial-of-a-nurse-led-facilitated-advance-care-planning-intervention
#8
Craig Sinclair, Kirsten Anne Auret, Sharon Frances Evans, Fiona Williamson, Siobhan Dormer, Anne Wilkinson, Kim Greeve, Audrey Koay, Dot Price, Fraser Brims
OBJECTIVE: Advance care planning (ACP) clarifies goals for future care if a patient becomes unable to communicate their own preferences. However, ACP uptake is low, with discussions often occurring late. This study assessed whether a systematic nurse-led ACP intervention increases ACP in patients with advanced respiratory disease. DESIGN: A multicentre open-label randomised controlled trial with preference arm. SETTING: Metropolitan teaching hospital and a rural healthcare network...
February 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28237869/the-role-of-image-guided-therapy-in-the-management-of-colorectal-cancer-metastatic-disease
#9
REVIEW
Thierry de Baere, Lambros Tselikas, Steven Yevich, Valérie Boige, Frederic Deschamps, Michel Ducreux, Diane Goere, France Nguyen, David Malka
The European Society for Medical Oncology (ESMO) have stressed that the option for treating oligometastatic disease is a strategy of local ablative therapy, the goal of which is to improve disease control. The spectrum of the local ablative therapy toolbox described by the ESMO includes surgical R0 resection, percutaneous ablation and intra-arterial therapies, the choice of treatment being left to the multidisciplinary team. Interventional therapy involving image-guided treatment offers the possibility of less invasive treatments for colorectal cancer metastases in the liver, lung and bone by preserving from toxicity distant healthy organs or even parts of the diseased organs...
February 23, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28237636/vaccine-education-of-medical-students-a-nationwide-cross-sectional-survey
#10
Solen Kernéis, Caroline Jacquet, Aurélie Bannay, Thierry May, Odile Launay, Pierre Verger, Céline Pulcini, Pierre Abgueguen, Séverine Ansart, Firouzé Bani-Sadr, Aurélie Bannay, Louis Bernard, Elisabeth Botelho-Nevers, David Boutoille, Nadim Cassir, Charles Cazanave, Elisa Demonchy, Olivier Epaulard, Manuel Etienne, Emmanuel Faure, Caroline Jacquet, Odile Launay, Vincent Le Moing, Xavier Lescure, Zoha Maakaroun-Vermesse, Guillaume Martin-Blondel, Thierry May, Frédéric Méchai, Guillaume Mellon, Marie-Caroline Meyohas, Lionel Piroth, Céline Pulcini, France Roblot, Jean-Luc Schmit, Albert Sotto, Pierre Tattevin, Renaud Verdon, Pierre Verger, Benjamin Wyplosz
Physicians play a primary role in vaccination of the population. Strong initial training of medical students is therefore essential to enable them to fulfill this role. This cross-sectional nationwide online survey conducted between September 2015 and January 2016 obtained 2,118 completed surveys from 6,690 eligible respondents (response rate, 32%) at 27 of 32 medical schools in France regarding their education about vaccination. The data were analyzed in April-June 2016. The survey covered their knowledge, attitudes, practices, and perceptions, and assessed their level of perceived preparedness for their future practice as interns...
February 22, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28237527/a-survey-of-pharmacists-knowledge-and-views-of-biosimilars-in-quebec-and-france
#11
A Adé, O Bourdon, J-F Bussières
OBJECTIVE: The objective of this study was to survey pharmacists' knowledge and views of biosimilars in Quebec and France. METHODS: An online and anonymous survey was conducted. The survey was divided into two parts including: (1) ten multiple choice questions on main characteristics that distinguish biosimilars from generic drugs; (2) fifteen statements on biosimilars key issues (interchangeability, immunogenicity risk management…). Pharmacists were asked to indicate their level of agreement to these statements using a 5-item Likert scale...
February 22, 2017: Annales Pharmaceutiques Françaises
https://www.readbyqxmd.com/read/28237413/impact-of-retinitis-pigmentosa-on-quality-of-life-mental-health-and-employment-among-young-adults
#12
Anne-Elisabeth Chaumet-Riffaud, Philippe Chaumet-Riffaud, Anaelle Cariou, Céline Devisme, Isabelle Audo, José-Alain Sahel, Saddek Mohand-Said
PURPOSE: To determine the relationship between visual function and quality of life, education, mental health and employment among young adults with Retinitis Pigmentosa (RP). DESIGN: Cross-sectional study. METHODS: Inclusion of 148 patients (mean age 38.2 +/- 7.1 yrs) diagnosed with RP, living in France. Quality of life was assessed using the National Eye Institute Visual Function Questionnaire (VFQ-25), mental state with the Hospital and Anxiety and Depression Scale (HADS) and employment with a specifically designed questionnaire...
February 22, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28237406/pharmacogenetics-based-personalized-therapy-levels-of-evidence-and-recommendations-from-the-french-network-of-pharmacogenetics-rnpgx
#13
Nicolas Picard, Jean-Christophe Boyer, Marie-Christine Etienne-Grimaldi, Chantal Barin-Le Guellec, Fabienne Thomas, Marie-Anne Loriot
More than 50 laboratories offer pharmacogenetic testing in France. These tests are restricted to a limited number of indications: prevention of serious adverse drug reactions; choice of most appropriate therapeutic option; dose adjustment for a specific drug. A very small proportion of these tests are mentioned in drug information labeling and the data provided (if any) are generally insufficient to ascertain whether a test is required and if it is useful. This article discusses the rationale for evaluating the performance and clinical usefulness of pharmacogenetics and provides, on behalf of the French national network of pharmacogenetics (RNPGx), three levels of recommendation for testing: essential, advisable, and possibly helpful...
January 30, 2017: Thérapie
https://www.readbyqxmd.com/read/28237354/-crizotinib-for-ros1-rearranged-non-small-cell-lung-cancer-patients
#14
Charlotte Domblides, Martine Antoine, Armelle Lavole, Jacques Cadranel, Marie Wislez
ROS1 fusions are rare mutations that preferentially concern young and non-smoker women. The ROS1-rearranged protein conserves an intact tyrosine kinase domain, leading to the constitutive activation of the ROS1 tyrosine kinase function and of its downstream pathways, that are known to be involved in tumorigenesis. These molecular abnormalities have shown their oncogenic potential in animals' models and in human, with an early effect on carcinogenesis. Several partners have been identified. Patients with non-small cell lung cancers (NSCLC) harbouring ROS1 alterations can received specific targeted therapies...
February 22, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/28236994/-electroconvulsive-therapy-and-level-of-evidence-from-causality-to-dose-effect-relationship
#15
J-A Micoulaud-Franchi, C Quilès, M Cermolacce, R Belzeaux, M Adida, E Fakra, J-M Azorin
OBJECTIVES: The first objective of this article is to summarize the history of electroconvulsive therapy (ECT) in psychiatry in order to highlight the transition from clinical level of evidence based on phenomenological descriptions to controlled trial establishing causal relationship. The second objective is to apply the criteria of causation for ECT, to focus on the dose-effect relationship criteria, and thus to analyze the conditions of application of these criteria for ECT. METHODS: A literature review exploring the use of electricity, ECT and electroencephalography (EEG) in psychiatry was conducted...
December 2016: L'Encéphale
https://www.readbyqxmd.com/read/28236922/preoperative-frailty-is-predictive-of-complications-after-major-lower-extremity-amputation
#16
Zachary B Fang, Frances Y Hu, Shipra Arya, Theresa W Gillespie, Ravi R Rajani
OBJECTIVE: Preoperative clinical frailty is increasingly used as a surrogate for predicting postoperative outcomes. Patients undergoing major lower extremity amputation (LEA) carry a high risk of perioperative morbidity and mortality, including high 30-day mortality and readmission rates. We hypothesized that preoperative frailty would be associated with an increased risk of postoperative mortality and readmission. METHODS: A retrospective review was performed for all patients who underwent transfemoral or transtibial amputation for any indication within a multi-institution system during a 5-year period...
March 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28236609/accuracy-of-teledentistry-for-diagnosing-dental-pathology-using-direct-examination-as-a-gold-standard-results-of-the-tel-e-dent-study-of-older-adults-living-in-nursing-homes
#17
Alain Queyroux, Bernard Saricassapian, Daniel Herzog, Karin Müller, Isabelle Herafa, Dorothée Ducoux, Benoît Marin, Thierry Dantoine, Pierre-Marie Preux, Achille Tchalla
IMPORTANCE: Dental neglect and high levels of unmet dental needs are becoming increasingly prevalent among elderly residents of long-term care facilities, although frail, elderly, and dependent populations are the most in need of professional dental care. Little is known about the validity of teledentistry for diagnosing dental pathology in nursing home residents. OBJECTIVES: To evaluate the accuracy of teledentistry for diagnosing dental pathology, assessing the rehabilitation status of dental prostheses, and evaluating the chewing ability of older adults living in nursing homes (using direct examination as a gold standard)...
February 21, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28236586/impaired-mobility-depressed-mood-cognitive-impairment-and-polypharmacy-are-independently-associated-with-disability-in-older-cancer-outpatients-the-prospective-physical-frailty-in-elderly-cancer-patients-pf-ec-cohort-study
#18
Frederic Pamoukdjian, Thomas Aparicio, Laurent Zelek, Marouane Boubaya, Philippe Caillet, Veronique François, Laure de Decker, Vincent Lévy, Georges Sebbane, Elena Paillaud
OBJECTIVE: To assess the prevalence of disability and the oncologic factors associated with disability in older outpatients with cancer. MATERIALS AND METHODS: The Physical Frailty in Elderly Cancer patients (PF-EC) study (France) is a prospective bicentric observational cohort study. Two hundred and ninety outpatients with cancer were included. A cross-sectional analysis of oncologic factors and geriatric variables associated with disability that were collected using a comprehensive geriatric assessment (CGA) was conducted...
February 21, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28236496/-inequity-of-compensation-trajectories-for-victims-of-medical-injuries-a-survey-in-the-french-out-of-court-settlement-mechanism
#19
I Parizot, I Cailbault, M Winance, J Barbot
BACKGROUND: In France little is known about either the characteristics of people who take legal action because they believe themselves to be victims of harm caused by medical activity, or about their complaint trajectory. The law of 4th March 2002 created an out-of-court settlement mechanism which aims to reduce inequitable access to compensation experienced by victims faced with legal procedures that are both lengthy and costly. This mechanism now occupies a central position among the avenues of recourse available to patients and their families...
February 21, 2017: Revue D'épidémiologie et de Santé Publique
https://www.readbyqxmd.com/read/28236464/future-life-expectancy-in-35-industrialised-countries-projections-with-a-bayesian-model-ensemble
#20
Vasilis Kontis, James E Bennett, Colin D Mathers, Guangquan Li, Kyle Foreman, Majid Ezzati
BACKGROUND: Projections of future mortality and life expectancy are needed to plan for health and social services and pensions. Our aim was to forecast national age-specific mortality and life expectancy using an approach that takes into account the uncertainty related to the choice of forecasting model. METHODS: We developed an ensemble of 21 forecasting models, all of which probabilistically contributed towards the final projections. We applied this approach to project age-specific mortality to 2030 in 35 industrialised countries with high-quality vital statistics data...
February 21, 2017: Lancet
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