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https://www.readbyqxmd.com/read/29346411/evaluation-of-hirst-type-spore-traps-in-outdoor-aspergillaceae-monitoring-during-large-demolition-work-in-hospital
#1
Sophie Tiphaine Loeffert, Philippe Vanhems, Estelle Tissot, Cédric Dananché, Pierre Cassier, Thomas Bénet, Michel Perraud, Michel Thibaudon, Marie-Paule Gustin
Demolition can generate fungal spore suspensions in association with various adverse health effects, such as high risk of invasive aspergillosis in immunocompromised patients. One block of Edouard Herriot Hospital was entirely demolished. The aim of the present study was to evaluate Hirst-type spore traps utility in monitoring outdoor Aspergillaceae (Aspergillus spp. + Penicillium spp.) spores in part of Edouard Herriot Hospital (Lyon, France) undergoing major demolition. Three periods were scheduled in 2015: (A) Gutting of building and asbestos removal, (B) Demolition of floors, (C) Excavation and earthwork...
2018: PloS One
https://www.readbyqxmd.com/read/29346183/near-infrared-spectroscopy-to-predict-organ-failure-and-outcome-in-sepsis-the-assessing-risk-in-sepsis-using-a-tissue-oxygen-saturation-aristos-study
#2
Stephen P J Macdonald, Frances B Kinnear, Glenn Arendts, Kwok M Ho, Daniel M Fatovich
OBJECTIVES: Sepsis is acute organ dysfunction in the setting of infection. An accurate diagnosis is important to guide treatment and disposition. Tissue oxygen saturation (StO2) can be estimated noninvasively by near-infrared spectroscopy (NIRS), and may be an indicator of microcirculatory dysfunction in early sepsis. We aimed to determine the utility of StO2 for sepsis recognition and outcome prediction among patients presenting to the emergency department (ED) with infection. PATIENTS AND METHODS: A multicentre, prospective, observational cohort study recruited patients who were being admitted to hospital with infection...
January 17, 2018: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
https://www.readbyqxmd.com/read/29346139/blood-biomarkers-for-evaluation-of-perinatal-encephalopathy-state-of-the-art
#3
Ernest M Graham, Allen D Everett, Jean-Christophe Delpech, Frances J Northington
PURPOSE OF REVIEW: The rapid progress in biomarker science is on the threshold of significantly changing clinical care for infants in the neonatal ICU. Infants with neonatal brain injuries will likely be the first group whose management is dramatically altered with point-of-care, rapidly available brain biomarker analysis. Providing an interim update on progress in this area is the purpose of this review. RECENT FINDINGS: Highlighted findings from the past 18 months of publications on biomarkers in neonatal brain injury include; Specific nonbrain markers of cardiac health and global asphyxia continue to provide information on brain injury after hypoxic-ischemic encephalopathy (HIE)...
January 17, 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29346039/evaluation-of-a-french-regional-telemedicine-network-dedicated-to-neurological-emergencies-a-14-year-study
#4
Elisabeth Medeiros de Bustos, Eric Berthier, Didier Chavot, Benjamin Bouamra, Thierry Moulin
BACKGROUND: Equality in healthcare between urban and rural areas is problematic in France. Telemedicine networks are expected to improve equality in expertise assessment. We aimed to evaluate the use and impact of a regional rural French telemedicine network, dedicated to medical and surgical neurological emergencies, on interhospital patient transfers. METHODS: Eight community hospital emergency departments were remotely connected to the only university hospital in Franche-Comté, France...
January 18, 2018: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/29344995/activation-of-human-cd141-and-cd1c-dendritic-cells-in-vivo-with-combined-tlr-3-and-tlr-7-8-ligation
#5
Frances E Pearson, Karshing Chang, Yoshihito Minoda, Ingrid M Leal Rojas, Oscar L Haigh, Ghazal Daraj, Kirsteen M Tullett, Kristen J Radford
Mice reconstituted with human hematopoietic stem cells are valuable models to study aspects of the human immune system in vivo. We describe a humanized mouse model (hu mice) in which fully functional human CD141+ and CD1c+ myeloid and CD123+ plasmacytoid dendritic cells (DC) develop from human cord blood CD34+ cells in immunodeficient mice. CD141+ DC are the human equivalents of murine CD8+ /CD103+ DC which are essential for the induction of tumor-inhibitory cytotoxic T lymphocyte (CTL) responses, making them attractive targets to exploit for the development of new cancer immunotherapies...
January 18, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29344407/tpf-induction-chemotherapy-increases-pd-l1-expression-in-tumour-cells-and-immune-cells-in-head-and-neck-squamous-cell-carcinoma
#6
Charlotte Leduc, Julien Adam, Emilie Louvet, Tony Sourisseau, Nicolas Dorvault, Marine Bernard, Elodie Maingot, Laura Faivre, Mei-Shiue Cassin-Kuo, Emilie Boissier, Marie-Charlotte Dessoliers, Angélique Robin, Odile Casiraghi, Caroline Even, Stéphane Temam, Ken A Olaussen, Jean-Charles Soria, Sophie Postel-Vinay
Background: Antiprogrammed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) therapies have demonstrated promising activity in advanced head and neck squamous cell carcinoma (HNSCC), with overall response rates of approximately 20% in unselected populations and survival benefit. Whether induction docetaxel, platinum and fluorouracil (TPF) modifies PD-L1 expression or tumour immune infiltrates is unknown. Patients and methods: Patients with locally advanced HNSCC treated at Gustave Roussy (Villejuif, France) between 2006 and 2013 by induction TPF followed by surgery were retrospectively considered...
2018: ESMO Open
https://www.readbyqxmd.com/read/29343987/performance-of-the-lace-index-to-predict-30-day-hospital-readmissions-in-patients-with-chronic-obstructive-pulmonary-disease
#7
Maryam A Hakim, Frances L Garden, Matthew D Jennings, Claudia C Dobler
Background and objective: Patients hospitalized for acute exacerbation of chronic obstructive pulmonary disease (COPD) have a high 30-day hospital readmission rate, which has a large impact on the health care system and patients' quality of life. The use of a prediction model to quantify a patient's risk of readmission may assist in directing interventions to patients who will benefit most. The objective of this study was to calculate the rate of 30-day readmissions and evaluate the accuracy of the LACE index (length of stay, acuity of admission, co-morbidities, and emergency department visits within the last 6 months) for 30-day readmissions in a general hospital population of COPD patients...
2018: Clinical Epidemiology
https://www.readbyqxmd.com/read/29343272/biotechnologies-that-empower-transgender-persons-to-self-actualize-as-individuals-partners-spouses-and-parents-are-defining-new-ways-to-conceive-a-child-psychological-considerations-and-ethical-issues
#8
REVIEW
Agnès Condat, Nicolas Mendes, Véronique Drouineaud, Nouria Gründler, Chrystelle Lagrange, Colette Chiland, Jean-Philippe Wolf, François Ansermet, David Cohen
Today, thanks to biomedical technologies advances, some persons with fertility issues can conceive. Transgender persons benefit also from these advances and can not only actualize their self-identified sexual identities but also experience parenthood. Based on clinical multidisciplinary seminars that gathered child psychiatrists and psychoanalysts interested in the fields of assisted reproduction technology (ART) and gender dysphoria, philosophers interested in bioethics, biologists interested in ART, and endocrinologists interested in pubertal suppression, we explore how new biotechnical advances, whether in gender transition or procreation, could create new ways to conceive a child possible...
January 17, 2018: Philosophy, Ethics, and Humanities in Medicine: PEHM
https://www.readbyqxmd.com/read/29342312/maladaptive-repetitive-thought-as-a-transdiagnostic-phenomenon-and-treatment-target-an-integrative-review
#9
REVIEW
Deanna M Kaplan, Roman Palitsky, Angela L Carey, Tracy E Crane, Cody M Havens, Michael R Medrano, Samantha J Reznik, David A Sbarra, Mary-Frances O'Connor
OBJECTIVE: Maladaptive repetitive thought (RT), the frequent and repetitive revisiting of thoughts or internal experiences, is associated with a range of psychopathological processes and disorders. We present a synthesis of prior research on maladaptive RT and develop a framework for elucidating and distinguishing between five forms of maladaptive RT. METHOD: In addition to the previously studied maladaptive RT (worry, rumination, and obsession), this framework is used to identify two additional forms of maladaptive RT (yearning and interoceptive RT)...
January 17, 2018: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/29342155/nanoscopic-x-ray-fluorescence-imaging-and-quantification-of-intracellular-key-elements-in-cryofrozen-friedreich-s-ataxia-fibroblasts
#10
Björn De Samber, Eline Meul, Brecht Laforce, Boel De Paepe, Joél Smet, Michiel De Bruyne, Riet De Rycke, Sylvain Bohic, Peter Cloetens, Rudy Van Coster, Peter Vandenabeele, Tom Vanden Berghe
Synchrotron radiation based nanoscopic X-ray fluorescence (SR nano-XRF) analysis can visualize trace level elemental distribution in a fully quantitative manner within single cells. However, in-air XRF analysis requires chemical fixation modifying the cell's chemical composition. Here, we describe first nanoscopic XRF analysis upon cryogenically frozen (-150°C) fibroblasts at the ID16A-NI 'Nano-imaging' end-station located at the European Synchrotron Radiation Facility (ESRF) in Grenoble (France). Fibroblast cells were obtained from skin biopsies from control and Friedreich's ataxia (FRDA) patients...
2018: PloS One
https://www.readbyqxmd.com/read/29341867/genetic-and-microbiome-influence-on-lipid-metabolism-and-dyslipidemia
#11
Maria Matey Hernandez, Frances Mk Mk Williams, Tilly Potter, Ana M Valdes, Tim Spector, Cristina Menni
Disruption in the metabolism of lipids is broadly classified under dyslipidemias and relate to the concentration of lipids in the blood. Dyslipidemia is a predictor of cardio-metabolic disease including obesity. Traditionally, the large inter-individual variation has been related to genetic factors and diet. Genome-wide association studies have identified over 150 loci related to abnormal lipid levels, explaining approximately 40% of the total variation. Part of the unexplained variance has been attributed to environmental factors including diet, but the extent of the dietary contribution remains unquantified...
December 20, 2017: Physiological Genomics
https://www.readbyqxmd.com/read/29341794/preseason-strength-assessment-of-the-rotator-muscles-and-shoulder-injury-in-handball-players
#12
Bénédicte Forthomme, Jean-Louis Croisier, François Delvaux, Jean-François Kaux, Jean-Michel Crielaard, Sophie Gleizes-Cervera
CONTEXT:   Few researchers have identified intrinsic risk factors for shoulder injury in team handball players by analyzing measurements of maximal isokinetic rotator muscle strength. OBJECTIVE:   To identify possible intrinsic risk factors for shoulder injury by analyzing measurements of maximal isokinetic rotator muscle strength. DESIGN:   Cross-sectional study. SETTING:   Male team handball senior divisions (the highest level) in France and Belgium...
January 17, 2018: Journal of Athletic Training
https://www.readbyqxmd.com/read/29341285/2-2-bipyridine-equipped-with-a-disulfide-dithiol-switch-for-coupled-two-electron-and-proton-transfer
#13
Mauricio Cattaneo, Christine Schiewer, Anne Schober, Sebastian Dechert, Inke Siewert, Franc Meyer
[1,2]dithiino[4,3-b:5,6-b']dipyridine (1) and its protonated open form 3,3'-dithiol-2,2'-bipyridine (2) were synthesised and their interconversion investigated. The X-ray structure of 2 revealed an anti orientation of the two pyridine units and a zwitterionic form. In depth electrochemical studies in combination with DFT calculations lead to a comprehensive picture of the redox chemistry of 1 in the absence and presence of protons. Initial one electron reduction at E1 = -1.97 V results in the formation of the radical anion 1red with much elongated S-S bond, which readily undergoes further reduction at E2 = -2...
January 17, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29341266/merkel-cell-carcinoma-in-france-a-registries-based-comprehensive-epidemiological-survey
#14
M Fondain, O Dereure, Z Uhry, A V Guizard, A S Woronoff, M Colonna, F Molinie, S Bara, M Velten, E Marrer, P Grosclaude, B Lapôtre-Ledoux, B Tretarre, B Guillot
BACKGROUND: Merkel cell carcinoma (MCC) is a rare primary cutaneous neuroendocrine carcinoma. Owing to its low incidence, epidemiological data are scarce and have never been analysed in France to identify the main epidemiological trends. METHODS: Data from MCC patients diagnosed between 1998 and 2010 were obtained from 11 French cancer registries in the FRANCIM network. The main epidemiological characteristics of MCC were investigated between 2006 and 2010 because comprehensive data were only available for this period...
January 16, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29340937/association-between-electronic-medical-record-implementation-of-default-opioid-prescription-quantities-and-prescribing-behavior-in-two-emergency-departments
#15
M Kit Delgado, Frances S Shofer, Mitesh S Patel, Scott Halpern, Christopher Edwards, Zachary F Meisel, Jeanmarie Perrone
No abstract text is available yet for this article.
January 16, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29340855/the-relationship-between-target-joints-and-direct-resource-use-in-severe-haemophilia
#16
Jamie O'Hara, Shaun Walsh, Charlotte Camp, Giuseppe Mazza, Liz Carroll, Christina Hoxer, Lars Wilkinson
OBJECTIVES: Target joints are a common complication of severe haemophilia. While factor replacement therapy constitutes the majority of costs in haemophilia, the relationship between target joints and non drug-related direct costs (NDDCs) has not been studied. METHODS: Data on haemophilia patients without inhibitors was drawn from the 'Cost of Haemophilia across Europe - a Socioeconomic Survey' (CHESS) study, a cost assessment in severe haemophilia A and B across five European countries (France, Germany, Italy, Spain, and the United Kingdom) in which 139 haemophilia specialists provided demographic and clinical information for 1285 adult patients...
January 16, 2018: Health Economics Review
https://www.readbyqxmd.com/read/29340714/taxonomical-resolution-and-distribution-of-bacterioplankton-along-the-vertical-gradient-reveals-pronounced-spatiotemporal-patterns-in-contrasted-temperate-freshwater-lakes
#17
J Keshri, A S Pradeep Ram, P A Nana, T Sime-Ngando
We examined the relationship between viruses and co-occurring bacterial communities across spatiotemporal scale in two contrasting freshwater lakes, namely meromictic Lake Pavin and dimictic Lake Aydat (Central France). Next-generation sequencing of 16S rRNA genes suggested distinct patterns in bacterioplankton community composition (BCC) between the lakes over depths and seasons. BCC were generally dominated by members of Actinobacteria, Proteobacteria, and Bacteroidetes covering about 95% of all sequences...
January 16, 2018: Microbial Ecology
https://www.readbyqxmd.com/read/29340606/leaves-not-roots-or-floral-tissue-are-the-main-site-of-rapid-external-pressure-induced-aba-biosynthesis-in-angiosperms
#18
Feng-Ping Zhang, Frances Sussmilch, David S Nichols, Amanda A Cardoso, Timothy J Brodribb, Scott A M McAdam
Rapid biosynthesis of abscisic acid (ABA) in the leaf, triggered by a decrease in cell volume, is essential for a functional stomatal response to vapour pressure deficit (VPD) in angiosperms. However, it is not known whether rapid biosynthesis of ABA is triggered in other plant tissues as well. Through the application of external pressure to flower, root and leaf tissues, we test whether a reduction in cell volume can trigger rapid increases in ABA levels across plant body in two species Solanum lycopersicum and Passiflora tarminiana...
January 11, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29340602/emergence-of-blactx-m-55-associated-with-fosa-rmtb-and-mcr-gene-variants-in-escherichia-coli-from-various-animal-species-in-france
#19
Agnese Lupo, Estelle Saras, Jean-Yves Madec, Marisa Haenni
Objectives: In Asian countries, blaCTX-M-55 is the second most common ESBL-encoding gene. blaCTX-M-55 frequently co-localizes with fosA and rmtB genes on epidemic plasmids, which remain sporadic outside Asia. During 2010-13, we investigated CTX-M-55-producing Escherichia coli isolates and their co-resistance to fosfomycin, aminoglycosides, fluoroquinolones and colistin as part of a global survey of ESBLs in animals in France. Methods: blaCTX-M-55, fosA, rmtB and plasmidic quinolone and colistin resistance genes were characterized by PCR, sequencing and hybridization experiments...
January 10, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29340439/-origin-of-the-scientific-arguments-underlying-qualitative-research
#20
Maria Cecília de Souza Minayo
This article analyzes the origin of the primary arguments that underpin the qualitative approach, covering the birthplace of comprehensive and dialectical thought in Germany, its expansion into other countries such as France and the United States, and its spread into Latin America. The historical journey of the text starts with the development of modern science, examining the first empirical works in the Chicago School and the subsequent period of ostracism of qualitative research. The text also evidences a revival of comprehensive theoretical and empirical perspectives from the 1960s onwards, accompanying the cultural movement that came to question the great theoretical narratives and give rise to reflections on subjectivity...
October 2017: Salud Colectiva
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