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https://www.readbyqxmd.com/read/29783060/sleep-dependent-consolidation-patterns-reveal-insights-into-episodic-memory-structure
#1
Carlos N Oyanedel, Anuck Sawangjit, Jan Born, Marion Inostroza
Episodic memory formation is considered a genuinely hippocampal function. Its study in rodents has relied on two different task paradigms, i.e. the so called "what-where-when" (WW-When) task and "what-where-which" (WW-Which) task. The WW-When task aims to assess the memory for an episode as an event bound into its context defined by spatial and distinct temporal information, the WW-Which task lacks the temporal component and introduces, instead, an "occasion setter" marking the broader contextual configuration in which the event occurred...
May 18, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29782990/a-certain-role-of-sod-cat-imbalance-in-pathogenesis-of-autism-spectrum-disorders
#2
Konstantin Yenkoyan, Hayk Harutyunyan, Aida Harutyunyan
The real impact of reactive oxygen species, antioxidant enzymes, mitochondrial dysfunction and chronic inflammation on the development of autism spectrum disorders (ASD) remains unclear, and even controversial. In this study we compared the plasma levels of antioxidant enzymes and their cofactors, markers of oxidative damage, and the respiratory burst in peripheral blood polymorphonuclear leukocytes (PMNL) as surrogate marker of chronic inflammation obtained from 10 children (4-10 year old) who met DSM-5 criteria and their siblings...
May 18, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29782955/loss-of-calretinin-and-parvalbumin-positive-interneurones-in-the-hippocampal-ca1-of-aged-alzheimer-s-disease-mice
#3
Fatima Zallo, Emanuela Gardenal, Alexei Verkhratsky, José Julio Rodríguez
Neuronal degeneration associated with Alzheimer's disease (AD), is linked to impaired calcium homeostasis and to changes in calcium-binding proteins (CBPs). The AD-related modification of neuronal CBPs remains controversial. Here we analyzed the presence and expression of calretinin (CR) and parvalbumin (PV) in the hippocampal CA1 neurones of 18 months old 3xTg-AD mice compared to non-Tg animals. We found a layer specific decrease in number of interneurones expressing CR and PV (by 33.7% and 52%, respectively)...
May 18, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29782850/histone-deacetylase-1-promotes-glioblastoma-cell-proliferation-and-invasion-via-activation-of-pi3k-akt-and-mek-erk-signaling-pathways
#4
Shun Li, Xiangrong Chen, Lifang Mao, Kashif Rafiq Zahid, Jun Wen, Liu Zhang, Maoying Zhang, Junwei Duan, Jie Duan, Xiaohong Yin, Yuanchuan Wang, Long Zhao, Xiaoping Tang, Xiangyu Wang, Guozheng Xu
Histone deacetylase 1 (HDAC1) plays a crucial role in cancer progression and development. This enzyme has been confirmed to be a key regulator of tumor biology functions, such as tumor cell proliferation, migration and invasion. However, HDAC1 expression in glioma remains controversial, and its specific function and molecular mechanism in glioblastoma is poorly understood. In this study, our findings demonstrated that protein and mRNA levels of HDAC1 were increased in glioma cell lines and glioma tissues compared to normal glial cell lines and non-neoplastic brain tissues, respectively...
May 18, 2018: Brain Research
https://www.readbyqxmd.com/read/29782801/epr-evidence-of-liquid-water-in-ice-an-intrinsic-property-of-water-or-a-self-confinement-effect
#5
Muthulakshmi Thangswamy, Priya Maheshwari, Dhanadeep Dutta, Vinayak G Rane, Pradeep Kumar Pujari
Liquid water (LW) existence in pure ice below 273 K has been a controversial aspect primarily because of the lack of experimental evidences. Recently, electron paramagnetic resonance (EPR) has been used to study deeply supercooled water in a rapidly-frozen polycrystalline ice. The same technique can also be used to probe the presence of LW in polycrystalline ice that has formed through a more conventional, slow cooling one. In this context, the present study aims to emphasize that in case of an external probe involving techniques such as EPR, the results are influenced by the binary phase (BP) diagram of the probe-water system, which also predicts the existence of LW domains in ice, upto the eutectic point...
May 21, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29782644/on-the-relationship-between-phylogenetic-diversity-and-trait-diversity
#6
Caroline M Tucker, T Jonathan Davies, Marc W Cadotte, William D Pearse
Niche differences are key to understanding the distribution and structure of biodiversity. To examine niche differences, we must first characterize how species occupy niche space, and two approaches are commonly used in the ecological literature. The first uses species traits to estimate multivariate trait space (so-called functional trait diversity, FD); the second quantifies the amount of time or evolutionary history captured by a group of species (phylogenetic diversity, PD). It is often-but controversially-assumed that these putative measures of niche space are at a minimum correlated and perhaps redundant, since more evolutionary time allows for greater accumulation of trait changes...
May 21, 2018: Ecology
https://www.readbyqxmd.com/read/29782635/effect-of-home-based-rehabilitation-for-hip-fracture-a-meta-analysis-of-randomized-controlled-trials
#7
Desheng Wu, Xiulan Zhu, Shaowei Zhang
BACKGROUND: Home-based rehabilitation following hip fracture may be beneficial; however, the evidence is controversial. The aim of this systematic review and meta-analysis was to evaluate the effectiveness of home-based rehabilitation in patients with hip fracture. METHODS: PubMed, Embase, Web of Science, EBSCO, and Cochrane Library databases were searched systematically. Randomized controlled trials (RCTs) assessing the effect of home-based rehabilitation for patients with hip fracture were included...
May 21, 2018: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29782363/regional-lymph-node-metastases-in-groin-sarcomas-a-diagnostic-and-therapeutic-challenge
#8
Deanna Wan Jie Ng, Ye Xin Koh, Grace Hwei Ching Tan, Khee Chee Soo, Melissa Ching Ching Teo
INTRODUCTION: The evaluation of lymph nodes and the role of groin dissection for groin sarcomas has been controversial where there have not been previous studies or guidelines published. In this study, we aim to first formulate a clinical approach in the evaluation of regional lymph nodal metastases. Second, we aim to also evaluate the role of regional lymphadenectomy in the setting of pathologically involved regional lymph nodes for groin sarcomas. MATERIALS AND METHODS: In total, 43 consecutive patients with groin sarcomas underwent treatment at the National Cancer Centre Singapore between 2002 and 2015...
May 18, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29782333/the-role-of-clinic-blood-pressure-for-the-diagnosis-of-hypertension
#9
Mohamed Ayan, Sabeeda Kadarath, Patrick T Campbell
PURPOSE OF REVIEW: Recent data from randomized clinical trials and updates to hypertension guidelines warrant a review of the literature for the diagnosis and management of hypertension in the clinic setting. Although there have been significant advances in ambulatory blood pressure (BP) monitoring and home BP monitoring, office BP (OBP) measurements remains the primary means of diagnosis and treatment. RECENT FINDINGS: The current review focuses on updated guidelines, proper technique, device selection, and the recent controversy regarding unattended BP measurements...
May 17, 2018: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29782248/-hepcidin-and-its-relationship-with-inflammation-in-old-and-older-patients-with-anemia-of-chronic-disease-associated-with-chf
#10
N I Solomakhina, E S Nakhodnova, E P Gitel, Y N Belenkov
BACKGROUND: Reported levels of hepcidin, the major regulator of systemic iron homeostasis in CHF patients, are controversial. Relationship of hepcidin with inflammation markers, which are typically increased in CHF, is understudied; this issue is practically unstudied in old and older CHF patients. AIM: To study the role of hepcidin in development of anemia of chronic disease (ACD) and the association of hepcidin with inflammation in old and older CHF patients. MATERIALS AND METHODS: Ninety old and older patients with IHD were evaluated...
2018: Kardiologiia
https://www.readbyqxmd.com/read/29782229/restraint-restrictive-intervention-and-seclusion-of-people-with-intellectual-and-developmental-disabilities
#11
Carli Friedman, Caitlin Crabb
Restraint, restrictive interventions, and seclusion are hotly contested practices with inconclusive evidence of their effectiveness. Because the use of restraint and seclusion on people with intellectual and developmental disabilities (IDD) is controversial and its effectiveness doubtable, this study was conducted to explore if and how they were permitted in Medicaid HCBS 1915(c) waivers, the largest providers of long-term services and supports (LTSS) for people with IDD. To do so, 111 fiscal year 2015 IDD waivers from across the nation were examined to determine if and how states permitted restraint, restrictive interventions, and seclusion...
June 2018: Intellectual and Developmental Disabilities
https://www.readbyqxmd.com/read/29781874/extended-use-of-systemic-menopausal-hormone-therapy
#12
Andrew M Kaunitz
Because clinical trial data assessing more than 10 years of hormone therapy (HT) use are not available, providing guidance to menopausal women regarding duration of systemic HT is controversial. However, clinicians routinely encounter this issue in practice. Using available evidence and clinical experience, this chapter provides guidance for clinicians who care for patients who may be candidates for extended use of systemic HT.
May 17, 2018: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29781859/nonoperating-room-anesthesia-for-gastrointestinal-endoscopic-procedures
#13
Otto S Lin, Wade Weigel
PURPOSE OF REVIEW: To assess the trends in nonoperating room anesthesia (NORA) for gastrointestinal endoscopy over the past few years, and to describe alternative methods of delivering propofol sedation in selected low-risk patients. RECENT FINDINGS: The use of NORA for routine gastrointestinal endoscopic procedures has been rising steadily over the past decade in the United States, considerably increasing healthcare costs. Because of this, there have been attempts to develop nonanesthesiologist-administered propofol sedation methods in low-risk patients...
May 16, 2018: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/29781854/salvage-of-threatened-cardiovascular-implantable-electronic-devices-case-series-and-review-of-literature
#14
Andrew M Simpson, W Tyler Rockwell, Roger A Freedman, W Bradford Rockwell
BACKGROUND: The treatment of infected or exposed cardiac pacing and defibrillator devices is controversial. The conservative and widely accepted management calls for removal of the device and leads with immediate or delayed replacement of new components in a new site. Lead extraction carries a 2% major complication risk. In this article, we describe our experience with device salvage techniques and review the current literature. METHODS: This is a retrospective case series of consecutive patients with infected, exposed, or at-risk implanted cardiac devices that were treated with aggressive surgical debridement, local pocket irrigation, and revision...
May 17, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29781789/the-influence-of-wearing-ski-boots-with-different-rigidity-characteristics-on-postural-control
#15
Frédéric Noé, Xavier García-Massó, Pauline Delaygue, Audrey Melon, Thierry Paillard
External supports that reduce ankle joint mobility such as ski-boots can impair postural control of healthy participants. Although this disruptive effect has been attributed to the rigidity of the external supports, the results remained controversial and no study has been conducted in order to evaluate the influence of ski-boots rigidity. Hence, the question about the influence of ankle support rigidity on postural control remains open. This study was therefore undertaken in order to investigate the effect of ski-boots rigidity on postural control...
May 21, 2018: Sports Biomechanics
https://www.readbyqxmd.com/read/29781421/molecular-phylogeny-based-on-six-nuclear-genes-suggests-that-echinococcus-granulosus-sensu-lato-genotypes-g6-g7-and-g8-g10-can-be-regarded-as-two-distinct-species
#16
Teivi Laurimäe, Liina Kinkar, Epp Moks, Thomas Romig, Rihab A Omer, Adriano Casulli, Gérald Umhang, Guna Bagrade, Malik Irshadullah, Mitra Sharbatkhori, Hossein Mirhendi, Francisco Ponce-Gordo, Silvia V Soriano, Antonio Varcasia, Mohammad Rostami-Nejad, Vanessa Andresiuk, Urmas Saarma
Tapeworms of the species complex of Echinococcus granulosus sensu lato (s. l.) are the cause of a severe zoonotic disease - cystic echinococcosis, which is listed among the most severe parasitic diseases in humans and is prioritized by the World Health Organization. A stable taxonomy of E. granulosus s. l. is essential to the medical and veterinary communities for accurate and effective communication of the role of different species in this complex on human and animal health. E. granulosus s. l. displays high genetic diversity and has been divided into different species and genotypes...
May 21, 2018: Parasitology
https://www.readbyqxmd.com/read/29781289/a-randomised-trial-comparing-spatio-temporal-gait-parameters-after-total-hip-arthroplasty-between-the-direct-anterior-and-direct-lateral-surgical-approaches
#17
Bryn O Zomar, Dianne Bryant, Susan Hunter, James L Howard, Edward M Vasarhelyi, Brent A Lanting
INTRODUCTION: Total hip arthroplasty (THA) is a successful procedure for relieving symptoms of severe osteoarthritis. Surgical approach is a key factor in early recovery and although controversial, little has been written about the direct anterior (DA) approach using objective early measures. METHODS: 78 participants were prospectively enrolled to undergo a THA through either a DA or direct lateral (DL) surgical approach. Outcome measures were collected preoperatively and at discharge from the hospital, and 2-, 6- and 12-weeks...
May 1, 2018: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29781133/inhibition-is-impaired-in-children-with-obsessive-compulsive-symptoms-but-not-in-those-with-tics
#18
Christian Mancini, Francesco Cardona, Valentina Baglioni, Sara Panunzi, Patrizia Pantano, Antonio Suppa, Giovanni Mirabella
BACKGROUND: Impaired inhibitory control is thought to be a core deficit in psychiatric disorders where patients exhibit problems with controlling urges. These problems include the urge to perform movements typical of Tourette syndrome and the urge to execute compulsive actions typical of obsessive-compulsive disorder. However, the picture emerging from studies that address this issue is controversial. Furthermore, most studies have only focused on reactive control (the ability of subjects to react to a stop signal), but not on proactive control (the ability of patients to shape their response strategies in anticipation of known task demands)...
May 21, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29781069/dual-and-triple-antithrombotic-therapies-current-patterns-of-practice-and-controversies
#19
Mark Crowther, John Eikelboom
Dual antiplatelet therapy (DAPT) has been the cornerstone of antithrombotic management for patients undergoing percutaneous coronary intervention (PCI). Despite low-quality evidence, triple antithrombotic therapy involving acetylsalicylic acid, clopidogrel and warfarin or non-vitamin K antagonist oral anticoagulant (NOAC) has been recommended in patients with concomitant atrial fibrillation undergoing PCI, who require long-term oral anticoagulation, although such strategy is associated with a substantially increased risk of bleeding compared with DAPT...
May 21, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29780866/molecular-imaging-what-is-right-and-what-is-an-illusion
#20
William E Klunk
Over the past 40 years, brain molecular imaging has evolved from measuring cerebral metabolism with fluorodeoxyglucose, to neuroreceptor imaging, to imaging pathological protein deposits. In the early going, the characteristics of successful molecular imaging radiotracers were defined, and a detailed "Process" was developed for the collection of basic pharmacodynamic and pharmacokinetic data. These data are essential for the interpretation of in vivo imaging data and for defining the strengths, weaknesses, and limitations of new tracers...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
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