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https://www.readbyqxmd.com/read/28938797/revisiting-the-safety-of-aspartame
#1
Arbind Kumar Choudhary, Etheresia Pretorius
Aspartame is a synthetic dipeptide artificial sweetener, frequently used in foods, medications, and beverages, notably carbonated and powdered soft drinks. Since 1981, when aspartame was first approved by the US Food and Drug Administration, researchers have debated both its recommended safe dosage (40 mg/kg/d) and its general safety to organ systems. This review examines papers published between 2000 and 2016 on both the safe dosage and higher-than-recommended dosages and presents a concise synthesis of current trends...
September 1, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/28938669/hepatitis-b-virus-infection-and-decreased-risk-of-stroke-a-meta-analysis
#2
Yaqin Wang, Jianping Xiong, Xi Chen, Meng Niu, Xiaowei Chen, Yuheng Guan, Kechuang Zheng, Ke Xu
Several studies have reported that hepatitis B virus (HBV) infection may decrease the risk of stroke. However, its association is controversial. Thus, we conducted a systematic review and meta-analysis to investigate the relationship between hepatitis B virus (HBV) infection and the risk of stroke. Relevant studies published before May 2017 were identified by searching PubMed, EMBASE, and ISI Web of Science. The relationships between HBV infection and the risk of stroke were assessed using odds ratio (OR)/risk ratio (RR) values and the corresponding 95% confidence intervals (CIs)...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938668/systematic-review-and-meta-analysis-cholecystectomy-and-the-risk-of-cholangiocarcinoma
#3
Jianping Xiong, Yaqin Wang, Hanchun Huang, Jin Bian, Anqiang Wang, Junyu Long, Ying Zheng, Xinting Sang, Yiyao Xu, Xin Lu, Haitao Zhao
Studies have reported that cholecystectomy may increase the risk of cholangiocarcinoma. However, this association is controversial. Thus, we conducted a systematic review and meta-analysis to explore the relationship between cholecystectomy and the risk of cholangiocarcinoma. Relevant studies were identified by searching PubMed, EMBASE, ISI Web of Science published before February 2017. We used the random effects model proposed by DerSimonian and Laird to quantify the relationship between cholecystectomy and risk of cholangiocarcinoma...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938665/meta-analysis-of-the-association-of-the-cyp2j2-g-50t-polymorphism-with-coronary-artery-disease
#4
Jian Chen, Dong-Fei Wang, Guo-Dong Fu, Jie Ding, Lei-Yang Chen, Jia-Lan Lv, Juan Fang, Xiang Yin, Xiao-Gang Guo
The association of the CYP2J2 G-50T polymorphism with coronary artery disease has been explored, but the results remain controversial. Thus, a meta-analysis was conducted to provide a comprehensive estimate of this association. We selected ten articles encompassing 12 independent case-control studies with 7063 cases and 10,453 controls for this meta-analysis. Overall, we found significant associations between the CYP2J2 G-50T polymorphism and coronary artery disease risk in three genetic models (allele model: odds ratio (OR) = 1...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938660/prognostic-value-of-programmed-death-ligand-1-in-sarcoma-a-meta-analysis
#5
Zhenhua Zhu, Zheng Jin, Mei Zhang, Yajun Tang, Guang Yang, Xiaowei Yuan, Jihang Yao, Dahui Sun
BACKGROUND: The prognostic role of programmed death-ligand 1 (PD-L1) in sarcoma remains controversial. We performed a meta-analysis so as to investigate the impact of PD-L1 on clinicopathlogical findings and survival outcomes in sarcoma. MATERIALS AND METHODS: A comprehensive search in PubMed, Embase and the Cochrane Library was conducted for relevant studies. The odds ratios or hazard ratios, at 95% confidence intervals were used as measures for investigation of the correlation between PD-L1 expression and clinicopathlogical features or survival outcomes...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938654/methylenetetrahydrofolate-reductase-c677t-polymorphism-and-the-risks-of-polycystic-ovary-syndrome-an-updated-meta-analysis-of-14-studies
#6
Lihong Wang, Wenting Xu, Caihong Wang, Mengyu Tang, Yujia Zhou
Some studies have reported an association between the Methylenetetrahydrofolate reductase (MTHFR) C667T genetic variant and risk of polycystic ovary syndrome (PCOS), although the results remain controversial. A systematic search was conducted on PubMed, Web of Science, EMBASE, Ovid, Chinese National Knowledge Databases and WanFang databases with relevant keywords. Fourteen studies of sixteen distinct populations involving 1478 PCOS cases and used to conduct a meta-analysis. The T allele was not significantly associated with increased risk of PCOS [OR: 1...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938570/pd-l1-expression-as-poor-prognostic-factor-in-patients-with-non-squamous-non-small-cell-lung-cancer
#7
Cuiling Zhou, Jianjun Tang, Huanhuan Sun, Xiaobin Zheng, Zhanyu Li, Tiantian Sun, Jie Li, Shuncong Wang, Xiuling Zhou, Hongliu Sun, Zhibin Cheng, Hongyu Zhang, Haiqing Ma
OBJECTIVES: The role of programmed cell death ligand 1 (PD-L1) in non-small cell lung cancer (NSCLC), especially according to histologic type, remains controversial. The purpose of this study was to assess PD-L1 expression and its association with overall survival (OS) and clinicopathologic characteristics in NSCLC. MATERIALS AND METHODS: Formalin-fixed paraffin-embedded specimens were obtained from 108 patients with surgically resected primary NSCLC. PD-L1 expression was assessed via immunohistochemistry using a histochemistry score system...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938551/overexpression-of-ubiquitin-specific-proteases-44-promotes-the-malignancy-of-glioma-by-stabilizing-tumor-promoter-securin
#8
Yongxiang Zou, Guanzhong Qiu, Lei Jiang, Zheng Cai, Wei Sun, Hongkang Hu, Chengyin Lu, Weilin Jin, Guohan Hu
Ubiquitin specific peptidase 44 (USP44) has been identified as an important component of spindle assemble checkpoint (SAC) to prevent the formation of aneuploidy. However, recent study raised a controversy about the effect of USP44 in tumor. Here, we first confirmed the intranuclear localization of USP44 by testing several specific antibodies to recognize endogenous USP44. Then, data from IHC and qRT-PCR assay indicated that the high expression of USP44 existed in high-grade glioma tissues and signified a poor prognosis...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938548/promoter-dna-methylation-analysis-reveals-a-combined-diagnosis-of-cpg-based-biomarker-for-prostate-cancer
#9
Yuanyuan Tang, Shusuan Jiang, Yinmin Gu, Weidong Li, Zengnan Mo, Yuanjie Huang, Tianyu Li, Yanling Hu
BACKGROUND: Prostate cancer (PCa) is the most common tumor in elderly men. However, the specificity and sensitivity of serum prostate-specific antigen levels in PCa diagnosis are controversial. This study aims to reveal a novel diagnosis biomarker in PCa. MATERIALS AND METHODS: The differential methylated CpG sites between 423 primary PCa and 39 adjacent samples from The Cancer Genome Atlas (TCGA) on Illumina HumanMethylation 450 platform were analyzed. The diagnostic methylation markers were mined using the Prediction Analysis of Microarrays package in Bioconductor...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938532/modulation-of-gdf11-expression-and-synaptic-plasticity-by-age-and-training
#10
Emanuela De Domenico, Giovanna D'Arcangelo, Isabella Faraoni, Mattia Palmieri, Virginia Tancredi, Grazia Graziani, Paola Grimaldi, Lucio Tentori
The Growth Differentiation Factor 11 (GDF11) has been controversially involved in the aging/rejuvenation process. To clarify whether GDF11 is differently expressed during aging, we have evaluated GDF11 levels in skeletal muscles and hippocampi of young and old mice, sedentary or subjected to a 12-weeks triweekly training protocol. The results of real-time PCR and Western blot analyses indicate that skeletal muscles of sedentary old mice express higher levels of GDF11 compared to young animals (p < 0.05)...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938505/-treatment-targets-in-hypertension
#11
Rainer Düsing
The optimal target blood pressure (BP) in the treatment of hypertensive patients remains controversial. Recently, the systolic blood pressure trial (SPRINT) has proposed that a target systolic blood pressure of < 120 mmHg provides prognostic benefit in elderly hypertensive patients at high cardiovascular risk. The results of SPRINT contrast with several other intervention trials which have investigated the effect of intense BP lowering (Secondary Prevention of Small Subcortical Strokes [SPS3], Action to Control Cardiovascular Risk in Diabetes [ACCORD], Heart Outcomes Prevention Evaluation [HOPE]-3)...
September 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28938386/size-matters-defining-critical-in-bone-defect-size
#12
Emil H Schemitsch
Bone defects are common and are associated with a significant burden of disease. The treatment of these injuries remains controversial, particularly those defects which are critical sized. Despite the need for decision making to be evidence based, a lack of consensus around definitions of critical-sized defects still exists, particularly around those defects in the 1-3 cm range. There is a need to define "critical" in bone defect size because noncritical defects may heal without planned reconstruction and secondary surgery...
October 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28938306/different-clinical-course-and-complications-in-interagency-registry-for-mechanically-assisted-circulatory-support-1-patients-managed-with-or-without-extracorporeal-membrane-oxygenation
#13
Jason J Han, Jennifer Chung, Carol W Chen, Ann C Gaffey, Alex Sotolongo, Christyna Justice, Alyse E Ameer, J Eduardo Rame, Christian Bermudez, Michael A Acker, Pavan Atluri
Extracorporeal membrane oxygenation (ECMO) as a bridge to left ventricular assist device (LVAD) implantation has shown promise in improving end-organ function and optimizing outcomes in some critically ill patients, but the practice remains controversial. Retrospective review of patients who received LVADs from May 2008 to September 2016 at a high-volume, tertiary care cardiovascular center was performed. Subjects were Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) class 1 patients divided into ECMO bridge and non-ECMO bridge cohorts...
September 21, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28938128/contralateral-axillary-lymph-node-metastasis-in-second-primary-breast-cancer-case-report-and-review-of-the-literature
#14
Jacob Gingerich, Edna Kapenhas, Jack Morgani, Alan Heimann
The rare entity of contra-lateral axillary lymph node metastasis(CAM) has been a debatable topic in the realm of breast cancer management for many years. There remains controversy over whether CAM should be considered distant metastasis or locoregional spread. It is also uncertain why or how CAM occurs. In this case report and review of the literature, we present an 81-year-old female with an apparent second primary breast cancer with synchronous CAM. This paper describes a scenario of altered lymphatic drainage which likely lead to CAM...
August 25, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28938107/lhermitte-duclos-disease-clinical-study-with-long-term-follow-up-in-a-single-institution
#15
Qiguang Wang, Si Zhang, Jian Cheng, Wenke Liu, Xuhui Hui
OBJECTIVE: LDD is a rare lesion, controversy about diagnosis and treatment of LDD and CS still exists. We aimed to clarify clinical and radiological characteristics, the optimal treatment timing and strategies of LDD with long-term follow-up. PATIENTS AND METHODS: From January 2004 to May 2017, 12 LDD patients were enrolled in our study. The clinical and radiological features, treatment strategies and long-term follow-up data were retrospectively analyzed. RESULTS: The mean follow-up was 89...
September 9, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28938029/prognosis-of-combining-remaining-teeth-and-implants-in-double-crown-retained-removable-dental-prostheses-a-systematic-review-and-meta-analysis
#16
Meifei Lian, Kai Zhao, Yunzhi Feng, Qian Yao
PURPOSE: The reliability of combining natural teeth and implants in one removable prosthesis is controversial. This systematic review was conducted to evaluate the prognosis of combined tooth/implant-supported double-crown-retained removable dental prostheses (DCR-RDPs) and to compare them with solely implant-supported prostheses with a minimum observation period of 3 years. MATERIALS AND METHODS: Electronic database (PubMed, Embase, Central, and SCI) and manual searches up to August 2016 were conducted to identify human clinical studies on tooth/implant-supported DCR-RDPs...
September 22, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28937908/relationship-between-dental-procedures-and-shunt-infections-in-hydrocephalic-patients-a-narrative-review
#17
Chidambaram Ramasamy
Oral physicians frequently encounter medically compromised patients in their everyday practice and a sizable number of these patients are in urgent need of specialized care. One such medically specialized category is that of patients suffering from hydrocephalus. A large number of medical reports and citations in support of surgical care of the hydrocephalic disorder are available in literature. However, reports on dental studies offer contradictory statements on the relationship between hydrocephalic shunts and oral manoeuvres...
September 22, 2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28937548/a-follow-up-study-of-electroconvulsive-therapy-in-children-and-adolescents
#18
Shanti Mitchell, Ehmer Hassan, Neera Ghaziuddin
OBJECTIVES: Electroconvulsive therapy (ECT) is an effective and a safe treatment for several severe psychiatric disorders across the age span. However, its use remains controversial and highly stigmatized especially among patients under 18 years. In this study, we examined current symptoms, attitudes, perception, and functioning of patients treated with ECT when they were less than 18 years old. METHODS: Participants had received ECT before age 18, between 1989 and 2015, at a tertiary medical center...
September 20, 2017: Journal of ECT
https://www.readbyqxmd.com/read/28937532/prevalence-risk-factors-and-characteristics-of-the-adding-on-phenomenon-in-idiopathic-scoliosis-after-correction-surgery-a-systematic-review-and-meta-analysis
#19
Mingyuan Yang, Yuechao Zhao, Xin Yin, Ziqiang Chen, Changwei Yang, Li Li, Ming Li
STUDY DESIGN: A systematic review and meta-analysis OBJECTIVE.: To discuss the prevalence, risk factors and characteristics of the 'adding-on' phenomenon in idiopathic scoliosis (IS). SUMMARY OF BACKGROUND DATA: There are controversies on the prevalence and risk factors of the 'adding-on' phenomenon. In addition, there is no comprehensive study to describe the characteristics of 'adding-on' in IS patients. METHODS: We performed a systematic online search using PubMed, EMBASE, Web of Science, the Cochrane Library and China WeiPu Library to identify eligible studies...
September 20, 2017: Spine
https://www.readbyqxmd.com/read/28937366/correlation-between-human-epidermal-growth-factor-receptor-2-oncoprotein-expression-and-some-prognostic-factors-in-papillary-thyroid-carcinoma
#20
Shervin Rabiee, Mohamadreza Jalali Nadoushan, Neda Mehdizade Rayeni, Iman Ansari
BACKGROUND: Thyroid cancer is one of the increasing cancer diagnoses in the United States. Papillary thyroid carcinoma (PTC) is the most common thyroid cancer. There are a few researches done determining the role of human epidermal growth factor receptor 2 HER2 (erbB-2) in PTC prognosis. They also have been controversial. This study is designed to determine the correlation of HER2 expression with tumor size, lymph node involvement, and capsular invasion as prognostic factors. MATERIALS AND METHODS: This research was a cross-sectional descriptive-analytic study...
July 2017: Indian Journal of Pathology & Microbiology
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