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https://www.readbyqxmd.com/read/29684252/index-of-healthy-aging-in-chinese-older-adults-china-health-and-retirement-longitudinal-study
#1
Chenkai Wu, Anne B Newman, Bi-Rong Dong, Michelle C Odden
OBJECTIVES: To characterize the distribution of an index of healthy aging-the Chinese Healthy Aging Index (CHAI)-in Chinese adults aged 60 and older according to sociodemographic characteristics and geographic region and to examine the association between the CHAI and mortality, disability, and functional limitation over 4 years. DESIGN: Nationally representative cohort study. SETTING: China Health and Retirement Longitudinal Study. PARTICIPANTS: Chinese adults aged 60 and older (N=3,740)...
April 23, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29683884/visit-to-visit-blood-pressure-variation-is-associated-with-outcomes-in-a-u-shaped-fashion-in-patients-with-myocardial-infarction-complicated-with-systolic-dysfunction-and-or-heart-failure-findings-from-the-ephesus-and-optimaal-trials
#2
João Pedro Ferreira, Kévin Duarte, Bertram Pitt, Kenneth Dickstein, John J V McMurray, Faiez Zannad, Patrick Rossignol
BACKGROUND: Visit-to-visit office blood pressure variation (BPV) has prognostic implications independent from mean BP across several populations in the cardiovascular field. The association of BPV with outcomes in patients with myocardial infarction (MI) with systolic dysfunction and/or heart failure is yet to be determined. METHODS: Two independent cohorts were assessed: the EPHESUS and the OPTIMAAL trials with a total of more than 12 000 patients. The primary outcome was all-cause death...
April 21, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29682989/coverage-of-accessory-renal-arteries-during-endovascular-aortic-aneurysm-repair-what-are-the-consequences-and-the-implications-for-clinical-practice
#3
Fabien Lareyre, Frédéric Panthier, Elixène Jean-Baptiste, Réda Hassen-Khodja, Juliette Raffort
An accessory renal artery (ARA) represents an anatomic variation which can challenge endovascular aortic aneurysm repair (EVAR). The aim of this review was to summarize the current knowledge on postoperative outcomes following ARA coverage during EVAR. We performed a systematic literature review. The MEDLINE database was searched on September 2017, and 8 relevant studies were included. The frequency of ARA in patients undergoing EVAR varied between 9.5% and 16.2%, and the frequency of ARA coverage varied between 5...
January 1, 2018: Angiology
https://www.readbyqxmd.com/read/29682496/inotropes-for-preterm-infants-50-years-on-are-we-any-wiser
#4
REVIEW
Aisling A Garvey, Elisabeth M W Kooi, Eugene M Dempsey
For almost half a century, inotropes have been administered to preterm infants with the ultimate goal of increasing their blood pressure. A number of trials, the majority of which focused on dopamine administration, have demonstrated increased blood pressure following inotrope administration in preterm infants and have led to continued use of inotropes in our neonatal units. We have also seen an increase in the number of potential agents available to the clinician. However, we now know that hypotension is a much broader concept than blood pressure alone, and our aim should instead be focused on improving end organ perfusion, specifically cerebral perfusion...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29677212/pulsatile-operation-of-a-continuous-flow-right-ventricular-assist-device-rvad-to-improve-vascular-pulsatility
#5
Boon C Ng, Matthias Kleinheyer, Peter A Smith, Daniel Timms, William E Cohn, Einly Lim
Despite the widespread acceptance of rotary blood pump (RBP) in clinical use over the past decades, the diminished flow pulsatility generated by a fixed speed RBP has been regarded as a potential factor that may lead to adverse events such as vasculature stiffening and hemorrhagic strokes. In this study, we investigate the feasibility of generating physiological pulse pressure in the pulmonary circulation by modulating the speed of a right ventricular assist device (RVAD) in a mock circulation loop. A rectangular pulse profile with predetermined pulse width has been implemented as the pump speed pattern with two different phase shifts (0% and 50%) with respect to the ventricular contraction...
2018: PloS One
https://www.readbyqxmd.com/read/29677050/changes-in-albuminuria-and-renal-outcome-in-patients-with-type-2-diabetes-and-hypertension-a-real-life-observational-study
#6
Francesca Viazzi, Antonio Ceriello, Paola Fioretto, Carlo Giorda, Pietro Guida, Giuseppina Russo, Eulalia Greco, Salvatore De Cosmo, Roberto Pontremoli
OBJECTIVES: To assess the predictive role of changes in albuminuria on the loss of renal function under antihypertensive treatment in patients with type 2 diabetes (T2D). METHODS: Clinical records from a total of 12 611 patients with hypertension and T2D, attending 100 antidiabetic centers in Italy, with normal estimated glomerular filtration rate (eGFR) at baseline and regular visits during a 4-year period were retrieved and analyzed. We assessed the association between changes in albuminuria status during a 1-year baseline period and time updated blood pressure (BP) and eGFR loss over the subsequent 4-year follow-up...
April 19, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29674188/the-chronobiology-of-blood-pressure-in-pregnancy
#7
REVIEW
Suzanne Pears, Angela Makris, Annemarie Hennessy
This review summarizes the literature to date on the subject of the chronobiology of blood pressure in pregnancy, and more specifically, in the common disease state of high blood pressure in pregnancy or preeclampsia. While the guidelines for treating hypertension in pregnancy use absolute measures to start treatment, they do not take into account the important rhythms of hypertension including nighttime and daytime readings. These variations are likely to have strong impacts on pregnancy outcomes, risk and long-term hypertension risk...
April 7, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29669715/genetic-and-environmental-contributions-to-the-covariation-between-cardiometabolic-traits
#8
Xu Chen, Ralf Kuja-Halkola, Zheng Chang, Robert Karlsson, Sara Hägg, Per Svensson, Nancy L Pedersen, Patrik K E Magnusson
BACKGROUND: The variation and covariation for many cardiometabolic traits have been decomposed into genetic and environmental fractions, by using twin or single-nucleotide polymorphism (SNP) models. However, differences in population, age, sex, and other factors hamper the comparison between twin- and SNP-based estimates. METHODS AND RESULTS: Twenty-four cardiometabolic traits and 700,000 genotyped SNPs were available in the study base of 10 682 twins from TwinGene cohort...
April 18, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29668855/the-negative-ultraslow-potential-electrophysiological-correlate-of-infarction-in-the-human-cortex
#9
Janos Lückl, Coline L Lemale, Vasilis Kola, Viktor Horst, Uldus Khojasteh, Ana I Oliveira-Ferreira, Sebastian Major, Maren K L Winkler, Eun-Jeung Kang, Karl Schoknecht, Peter Martus, Jed A Hartings, Johannes Woitzik, Jens P Dreier
Spreading depolarizations are characterized by abrupt, near-complete breakdown of the transmembrane ion gradients, neuronal oedema, mitochondrial depolarization, glutamate excitotoxicity and activity loss (depression). Spreading depolarization induces either transient hyperperfusion in normal tissue; or hypoperfusion (inverse coupling = spreading ischaemia) in tissue at risk for progressive injury. The concept of the spreading depolarization continuum is critical since many spreading depolarizations have intermediate characteristics, as opposed to the two extremes of spreading depolarization in either severely ischaemic or normal tissue...
April 16, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29659628/interactions-between-genetic-variation-and-cellular-environment-in-skeletal-muscle-gene-expression
#10
D Leland Taylor, David A Knowles, Laura J Scott, Andrea H Ramirez, Francesco Paolo Casale, Brooke N Wolford, Li Guan, Arushi Varshney, Ricardo D'Oliveira Albanus, Stephen C J Parker, Narisu Narisu, Peter S Chines, Michael R Erdos, Ryan P Welch, Leena Kinnunen, Jouko Saramies, Jouko Sundvall, Timo A Lakka, Markku Laakso, Jaakko Tuomilehto, Heikki A Koistinen, Oliver Stegle, Michael Boehnke, Ewan Birney, Francis S Collins
From whole organisms to individual cells, responses to environmental conditions are influenced by genetic makeup, where the effect of genetic variation on a trait depends on the environmental context. RNA-sequencing quantifies gene expression as a molecular trait, and is capable of capturing both genetic and environmental effects. In this study, we explore opportunities of using allele-specific expression (ASE) to discover cis-acting genotype-environment interactions (GxE)-genetic effects on gene expression that depend on an environmental condition...
2018: PloS One
https://www.readbyqxmd.com/read/29656621/effect-of-myoarchitectonic-spinolaminoplasty-on-concurrent-hypertension-in-patients-with-cervical-spondylotic-myelopathy
#11
Kazushige Itoki, Ryu Kurokawa, Tetsuro Shingo, Phyo Kim
OBJECTIVE: When treating patients with cervical spondylotic myelopathy (CSM), we often note amelioration in concomitant hypertension after surgery. To assess the effects of surgery and the mechanisms thereof, blood pressure (BP) and parasympathetic nervous activity were monitored prospectively in CSM patients undergoing surgery. METHODS: Sixty-eight consecutive CSM patients who underwent surgery with myoarchitectonic spinolaminoplasty were enrolled. BP and electrocardiography were recorded preoperatively and at 1, 3, and 6 months postoperatively...
March 2018: Neurospine
https://www.readbyqxmd.com/read/29651955/increases-in-peripheral-systolic-pressure-levels-and-z-score-associate-gradual-aortic-pressure-increase-and-functional-arterial-impairment-in-children-and-adolescents
#12
Yanina Zocalo, Mariana Marin, Santiago Curcio, Victoria Garcia-Espinosa, Pedro Chiesa, Gustavo Giachetto, Edmundo I Cabrera-Fischer, Daniel Bia
BACKGROUND: Arterial changes associated with children and adolescents high blood pressure (HBP) states would vary depending on the arterial type, arterial indexes considered and/or on blood pressure (BP) levels. AIMS: To determine in children and adolescents: 1) if there is gradual structural-functional arterial impairment associated with gradual peripheral (brachial) systolic BP (pSBP) level or z-score increases, and 2) whether subjects with HBP levels and those with normal BP differ in the profiles of arterial changes associated with pSBP deviations...
April 13, 2018: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29650049/variation-in-general-supportive-and-preventive-intensive-care-management-of-traumatic-brain-injury-a-survey-in-66-neurotrauma-centers-participating-in-the-collaborative-european-neurotrauma-effectiveness-research-in-traumatic-brain-injury-center-tbi-study
#13
Jilske A Huijben, Victor Volovici, Maryse C Cnossen, Iain K Haitsma, Nino Stocchetti, Andrew I R Maas, David K Menon, Ari Ercole, Giuseppe Citerio, David Nelson, Suzanne Polinder, Ewout W Steyerberg, Hester F Lingsma, Mathieu van der Jagt
BACKGROUND: General supportive and preventive measures in the intensive care management of traumatic brain injury (TBI) aim to prevent or limit secondary brain injury and optimize recovery. The aim of this survey was to assess and quantify variation in perceptions on intensive care unit (ICU) management of patients with TBI in European neurotrauma centers. METHODS: We performed a survey as part of the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study...
April 13, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29648976/adherence-to-brain-trauma-foundation-guidelines-for-management-of-traumatic-brain-injury-patients-and-its-effect-on-outcomes-systematic-review
#14
Yahya Khormi, Ibrahim Gosadi, Sandy Campbell, Ambikaipakan Senthilselvan, Cian O'Kelly, David Zygun
Traumatic brain injury (TBI) management based on Brain Trauma Foundation (BTF) guidelines is widely accepted and thought to improve outcome. The objectives of this study are to provide an overview of adherence to BTF guidelines and to explore which factors influence adherence. We conducted a search of relevant electronic bibliographic databases. Twenty articles met inclusion/exclusion criteria out of 666 papers screened. All were cohort studies. Wide variation in adherence to BTF guidelines was observed with a median of 66...
March 6, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29644558/finger-and-forehead-photoplethysmography-derived-pulse-pressure-variation-and-the-benefits-of-baseline-correction
#15
Shaoxiong Sun, Wouter H Peeters, Rick Bezemer, Xi Long, Igor Paulussen, Ronald M Aarts, Gerrit J Noordergraaf
To non-invasively predict fluid responsiveness, respiration-induced pulse amplitude variation (PAV) in the photoplethysmographic (PPG) signal has been proposed as an alternative to pulse pressure variation (PPV) in the arterial blood pressure (ABP) signal. However, it is still unclear how the performance of the PPG-derived PAV is site-dependent during surgery. The aim of this study is to compare finger- and forehead-PPG derived PAV in their ability to approach the value and trend of ABP-derived PPV. Furthermore, this study investigates four potential confounding factors, (1) baseline variation, (2) PPV, (3) ratio of respiration and heart rate, and (4) perfusion index, which might affect the agreement between PPV and PAV...
April 11, 2018: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29643714/combined-effect-of-acid-sensing-ion-channel-3-and-transient-receptor-potential-vanilloid-1-gene-polymorphisms-on-blood-pressure-variations-in-taiwanese
#16
Leay-Kiaw Er, Ming-Sheng Teng, Semon Wu, Lung-An Hsu, I-Shiang Tzeng, Ching-Feng Cheng, Hsin-I Chang, Hsin-Hua Chou, Yu-Lin Ko
Objectives: Both acid-sensing ion channel acid-sensing ion channel 3 (ASIC3) and transient receptor potential vanilloid 1 (TRPV1) have been proposed to be involved in the pathophysiology of hypertension. Common colocalization of ASIC3 and TRPV1 channels in the same sensory neuron has been reported. We aimed to study the combined ASIC3 and TRPV1 gene polymorphisms in the risk of hypertension. Materials and Methods: To test the statistical association between genetic polymorphisms of the ASIC3 and TRPV1 genes and blood pressure (BP) variations in Taiwanese, 551 unrelated individuals (286 men and 265 women) having routine health examinations were recruited...
January 2018: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/29627767/attended-and-unattended-automated-office-blood-pressure-measurements-have-better-agreement-with-ambulatory-monitoring-than-conventional-office-readings
#17
Emmanuel A Andreadis, Charalampia V Geladari, Epameinondas T Angelopoulos, Florentia S Savva, Anna I Georgantoni, Vasilios Papademetriou
BACKGROUND: Automated office blood pressure (AOBP) measurement is superior to conventional office blood pressure (OBP) because it eliminates the "white coat effect" and shows a strong association with ambulatory blood pressure. METHODS AND RESULTS: We conducted a cross-sectional study in 146 participants with office hypertension, and we compared AOBP readings, taken with or without the presence of study personnel, before and after the conventional office readings to determine whether their variation in blood pressure showed a difference in blood pressure values...
April 7, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29624524/blood-pressure-coefficient-of-variation-and-its-association-with-cardiac-surgical-outcomes
#18
Sayuri P Jinadasa, Ariel Mueller, Varesh Prasad, Kathirvel Subramaniam, Thomas Heldt, Victor Novack, Balachundhar Subramaniam
BACKGROUND: Multiple studies completed in the ambulatory nonsurgical setting show a significant association between short- and long-term blood pressure variability and poor outcomes. However, perioperative blood pressure variability outcomes have not been well studied, especially in the cardiac surgical setting. In this study, we sought to assess whether systolic and mean arterial blood pressure variability were associated with 30-day mortality and in-hospital renal failure in patients undergoing cardiac surgery requiring cardiopulmonary bypass...
April 5, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29619872/association-of-short-term-blood-pressure-variability-with-cardiovascular-mortality-among-incident-hemodialysis-patients
#19
Yiduo Feng, Ziqian Li, Jing Liu, Fang Sun, Lijie Ma, Yang Shen, Yilun Zhou
OBJECTIVE: To investigate the association of short-term blood pressure variability (BPV) with cardiovascular mortality in hemodialysis (HD) patients, using a reliable index called average real variability (ARV), and to assess the factors associated with ARV in incident HD population. METHODS: A total of 103 HD patients were recruited, with 44-h ambulatory blood pressure monitoring performed after the midweek HD session. Systolic BPV was assessed by SD, coefficient of variation (CV), and ARV, respectively...
November 2018: Renal Failure
https://www.readbyqxmd.com/read/29618011/effects-of-diazoxide-mediated-insulin-suppression-on-glucose-and-lipid-metabolism-in-non-diabetic-obese-men
#20
Sandra Loves, Lenneke van Groningen, Margreet Filius, Marja Mekking, Tom Brandon, Cees J Tack, Ad Hermus, Hans de Boer
Introduction: It has been suggested that stimulation of lipolysis by Diazoxide (DZX)-mediated insulin suppression may be useful as a treatment of obesity. However, the optimal dose to promote lipolysis without causing hyperglycemia is currently unknown. Aim: To assess the effects of DZX in non-diabetic obese men on lipid and glucose metabolism. Methods: Double-blind, placebo-controlled, 6-month trial in men with a BMI of 30 - 37.5 kg/m2 treated with a combination of caloric restriction, a standardized exercise program, and DZX or placebo dose escalation...
March 29, 2018: Journal of Clinical Endocrinology and Metabolism
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