Read by QxMD icon Read

blood pressure variation

M Nagai, K Dote, M Kato, S Sasaki, N Oda, E Kagawa, Y Nakano, A Yamane, Y Kubo, T Higashihara, S Miyauchi, W Harada, H Masuda
In a cross-sectional study, visit-to-visit blood pressure (BP) variability was shown to be associated with artery remodelling. Here, we investigated the impact of visit-to-visit BP variability and average BP on the carotid artery remodelling progression in high-risk elderly according to different classes of antihypertension medication use/non-use. BP measurements and carotid ultrasound were performed in the common carotid artery in 164 subjects (mean age 79.7 years at baseline, 74.7% females) with one or more cardiovascular risk factors...
October 20, 2016: Journal of Human Hypertension
Ana Rosa Cunha, Jenifer D'El-Rei, Fernanda Medeiros, Bianca Umbelino, Wille Oigman, Rhian M Touyz, Mario F Neves
BACKGROUND: Epidemiological studies demonstrate an inverse association between serum magnesium and incidence of cardiovascular disease. Diuretics commonly cause hypomagneseamia. METHOD: We evaluated effects of magnesium supplementation on blood pressure (BP) and vascular function in thiazide-treated hypertensive women in a randomized, double-blind, clinical trial. Hypertensive women (40-65 years) on hydrochlorothiazide and mean 24-h BP at least 130/80 mmHg were divided into placebo and supplementation (magnesium chelate 600 mg/day) groups...
October 18, 2016: Journal of Hypertension
Luca Villa, Roberta Buono, Mara Ferrandi, Isabella Molinari, Fabio Benigni, Arianna Bettiga, Giorgia Colciago, Masami Ikehata, Elisabetta Messaggio, Maria Pia Rastaldi, Francesco Montorsi, Andrea Salonia, Paolo Manunta
Warm renal ischemia performed during partial nephrectomy has been found to be associated with kidney disease. Since endogenous ouabain (EO) is a neuro-endocrine hormone involved in renal damage, we evaluated the role of EO in renal ischemia-reperfusion injury (IRI). We measured plasma and renal EO variations and markers of glomerular and tubular damage (nephrin, KIM-1, Kidney-Injury-Molecule-1, α1 Na-K ATPase) and the protective effect of the ouabain inhibitor, rostafuroxin. We studied five groups of rats: (1) normal; (2) infused for eight weeks with ouabain (30 µg/kg/day, OHR) or (3) saline; (4) ouabain; or (5) saline-infused rats orally treated with 100 µg/kg/day rostafuroxin for four weeks...
October 14, 2016: International Journal of Molecular Sciences
Fu Liang Ng, Ebbe Boedtkjer, Shu Ye, Mark Caulfield
OBJECTIVE: Chromosome 3p24.1 containing the SLC4A7 gene has been identified by genome-wide association studies as one of the genomic loci that influence blood pressure. SLC4A7 encodes electroneutral Na/HCO3 co-transporter (NBCn1) which regulates intracellular pH (pHi) in various tissues including vascular smooth muscle and endothelium, with knockout models demonstrating an altered blood pressure phenotype. We conducted a functional study of blood pressure-associated single nucleotide polymorphisms at the SLC4A7 locus in primary cultures of human vascular smooth muscle and endothelial cells...
September 2016: Journal of Hypertension
Rae Woong Park
Big data indicates the large and ever-increasing volumes of data adhere to the following 4Vs: volume (ever-increasing amount), velocity (quickly generated), variety (many different types), veracity (from trustable sources). The last decade has seen huge advances in the amount of data we routinely generate and collect in pretty much everything we do, as well as our ability to use technology to analyze and understand it. The routine operation of modern health care systems also produces an abundance of electronically stored data on an ongoing basis as a byproduct of clinical practice...
September 2016: Journal of Hypertension
Telmo Pereira, Armindo Almeida, João Maldonado, Jorge Conde
OBJECTIVE: The Moens-Korteweg equation predicts changes in pulse wave velocity (PWV) following changes in arterial radius, therefore an increase in arterial radius, as seen in a reactive hyperaemia (RH) condition, should slow PWV over a given arterial segment. If this assumption is true, than the deceleration of PWV over the brachial artery (flow-mediated slowing - FMS) should be an equivalent signal of endothelial function during a conventional RH flow-mediated dilation (FMD) procedure...
September 2016: Journal of Hypertension
Haijiang Dai, Yao Lu, Shouling Wu, Hong Yuan
OBJECTIVE: The aim of this study was to prospectively explore the association between visit-to-visit variability of blood pressure (BP) and the risks of stroke and its subtypes. DESIGN AND METHOD: A total of 57 927 participants from a Chinese urban community who have completed all 3 visits between 2006 and 2010 were included in this study. The variability of BP was defined as the coefficient of variation (CV) across 3 visits. Participants without BP information loss or a history of stroke event were then followed until the end of the study...
September 2016: Journal of Hypertension
Hooi Min Lim, Yook Chin Chia, Siew Mooi Ching
OBJECTIVE: We aim to examine the relationship between visit-to-visit systolic blood pressure variability (BPV) and decline in renal function in patients with hypertension and determine the level of systolic BPV that contribute to significant renal function decline. DESIGN AND METHOD: This is a 15-year (1998-2012) retrospective cohort study of 825 hypertensive patients with normal renal function at baseline in a primary care clinic. Three monthly blood pressure readings per year were retrieved from the 15 years of clinic visits...
September 2016: Journal of Hypertension
Alejandro De La Sierra, Julia Pareja, Angela Barrera, Sergi Yun, Pedro Armario, Anna Oliveras
OBJECTIVE: To compare the effect on circadian blood pressure (BP) and BP variability of treatment with sympathetic renal denervation versus spironolactone in resistant hypertensive patients. DESIGN AND METHOD: The DENERVHTA study was a randomized, open trial in 23 resistant hypertensive patients (office systolic BP > 150 and 24-hour systolic BP > 140, while on treatment with at least 3 antihypertensive drugs, one of them a diuretic). Good compliance with antihypertensive medication and eligibility of renal arteries anatomy was ensured before randomization...
September 2016: Journal of Hypertension
Levon Kocharyan, Lilit Baghdasaryan
OBJECTIVE: About 40% of adult population suffers from arterial hypertension and its complications are in the leading places among overall and cerebrovascular mortality. Despite the broad range of available medications and its combinations, less than half of the patients have adequately controlled blood pressure worldwide. And arterial hypertension has a great social and economic impact. Our goal was to create a program which will give an opportunity for long term control of arterial hypertension and closer follow up...
September 2016: Journal of Hypertension
Martin Schultz, Leigh Blizzard, Velandai Srikanth, Panagiota Veloudi, James Sharman
OBJECTIVE: Assessment of blood pressure (BP) in children and adolescents is based on percentiles according to age, sex and height, with the difference between the 90th (pre-hypertension) and 95th (hypertension) percentiles being only 3-4 mmHg. Although BP is known to be highly variable in children, which may influence the accuracy of BP assessment, the magnitude and direction of BP variability (BPV) over consecutive measurements has never been investigated in this population. We aimed to determine BPV, and factors influencing BPV, over consecutive measurements in a large representative population of Australian children and adolescents...
September 2016: Journal of Hypertension
Barrett Jeffers, Duo Zho
OBJECTIVE: High blood pressure variability (BPV) and worsening kidney function have both independently been linked to a higher risk for cardiovascular events. We aimed to investigate the impact of kidney function on BPV (using estimated glomerular filtration rate, eGFR), via a retrospective post hoc analysis of patients with hypertension. DESIGN AND METHOD: Subject level data were extracted from the ASCOT-BPLA (N = 18,852) and ALLHAT (N = 26,441) databases; both were randomized, active controlled studies, and treatment duration for hypertension was at least 4-years...
September 2016: Journal of Hypertension
Martin O'Donnell
Salt (sodium chloride) is the primary source of sodium in the diet. Sodium is an essential nutrient, required for normal human physiology. Excess sodium intake is a risk factor for hypertension and cardiovascular disease. Observational studies have reported a curvilinear increase in blood pressure with increasing sodium intake, more marked in people with high sodium intakes and hypertension. Interventional clinical trials have demonstrated the efficacy of reduced sodium intake on reducing blood pressure, although the interventions employed in these trials are not generalizable to most settings (intensive dietary counselling or feeding trials)...
September 2016: Journal of Hypertension
Stephen Harrap, Katrina Scurrah, Angela Lamantia, Justine Ellis
OBJECTIVE: Genes encoding key elements of the renin-angiotensin-aldosterone system (RAAS) cascade have been previously but inconsistently associated with blood pressure. Sex-dependency might be important here and functional genetic polymorphisms might exhibit epistatic effects. DESIGN AND METHOD: We assessed variation in the genes encoding renin (REN), angiotensinogen (AGT), angiotensin converting enzyme (ACE), angiotensin II type 1 receptor (AGTR1) and aldosterone synthase (CYP11B2)...
September 2016: Journal of Hypertension
Kazuomi Kario, Deepak Bhatt, Sandeep Brar, George Bakris
OBJECTIVE: Dynamic changes in 24-hour ambulatory blood pressure (BP) are associated with basal autonomic function and cardiovascular risk. We examined the influence of ethnicity on these parameters by comparing ambulatory BP dynamics in Japanese, African American (AA), and white populations with treatment-resistant hypertension. DESIGN AND METHOD: Both HTN-Japan (N = 41) and SYMPLICITY HTN-3 (N = 384 white and 140 AA) enrolled patients with office systolic BP ≥ 160 mmHg and 24-hour ambulatory systolic BP ≥ 135 mmHg while on ≥3 antihypertensive medications...
September 2016: Journal of Hypertension
Chang-Sheng Sheng, Yi-Bang Cheng, Fang-Fei Wei, Wen-Yi Yang, Qian-Hui Guo, Fei-Ka Li, Qi-Fang Huang, Lutgarde Thijs, Yan Li, Jan A Staessen, Ji-Guang Wang
OBJECTIVE: No previous study addressed the relative contributions of environmental and genetic cues to the diurnal blood pressure rhythmicity. We firstly investigated the explained variance of environmental and clock genes in relation to the night-to-day ratio (NDR) and morning surge (MS), respectively. DESIGN AND METHOD: From 24-h ambulatory recordings of systolic blood pressure (SBP) obtained in untreated Chinese patients (51% women; mean age, 51 years), we computed NDR in 897 and MS in 637...
September 2016: Journal of Hypertension
Yanina Timasheva, Timur Nasibullin, Elvira Imaeva, Gulchagra Mirsaeva, Olga Mustafina
OBJECTIVE: Systemic inflammation and impaired function of endothelium play a significant role in the development of blood pressure elevation. The population of Tatars residing in the Volga-Ural region of Russia is characterized by a unique combination of European and Asian genetic ancestry, and is an interesting object for genetic study. Our aim was to analyze an association between essential hypertension and the polymorphic markers of genes encoding for molecules involved in blood pressure control and the regulation of endothelial function and inflammation in the group of 530 Tatars from the Republic of Bashkortostan, Russia...
September 2016: Journal of Hypertension
Eeva Juhanoja, Jouni Johansson, Lutgarde Thijs, Kei Asayama, Atsushi Hozawa, Takayoshi Ohkubo, George Stergiou, Ichiro Tsuji, Yutaka Imai, Antti Jula, Teemu Niiranen, Jan Staessen
OBJECTIVE: Increased home blood pressure (BP) variability seems to be associated with cardiovascular disease, but the lack of operational thresholds limits its clinical application. Our aim was to define outcome-driven thresholds for day-to-day home BP variability in the general population. DESIGN AND METHOD: The study population consisted of 6312 community-dwelling participants from Ohasama, Japan; Tsurugaya, Japan; Didima, Greece; and Finland. The participants were divided into ten groups by deciles of home BP variability, defined as the coefficient of variation (CV) of the first measurements of each day between 5:00 and 12:00 AM to account for between-cohort differences in measurement protocols...
September 2016: Journal of Hypertension
Kohji Shirai
BACKGROUND: The cardio-ankle vascular index (CAVI) is a new arterial stiffness index of the arterial tree from the origin of the aorta to the ankle, and was essentially derived from the stiffness parameterβtheory proposed by Hayashi. The conspicuous feature of CAVI is independency from blood pressure at the time of measurement. AIM: The purpose is to clarify the meaning of CAVI as a surrogate marker of arteriosclerosis, and also the role of CAVI in the blood pressure control system...
September 2016: Journal of Hypertension
Kazuomi Kario
Out-of-office blood pressure (BP) measured by home BP monitoring (HBPM) or ambulatory BP monitoring (ABPM) was demonstrated to be superior to office BP for the prediction of cardiovascular events. The ABPM is superior to HBPM for detecting the all the BP-related risks throughout 24-hr, and the self-measured HBPM underestimates the risk of daytime stress hypertension and nocturnal hypertension. However, ABPM cannot always be provided in clinical practice, and home BP monitoring can be superior to ABPM as part of a home BP-guided antihypertension strategy in clinical practice...
September 2016: Journal of Hypertension
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"