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https://www.readbyqxmd.com/read/28102195/positive-association-between-kcnj5-rs2604204-a-c-polymorphism-and-plasma-aldosterone-levels-but-also-plasma-renin-and-angiotensin-i-and-ii-levels-in-newly-diagnosed-hypertensive-chinese-a-case-control-study
#1
H Wang, C Weng, H Chen
Variants in G protein-coupled inward rectifier K(+) channels 4 (GIRK4 also known as KCNJ5) gene are associated with primary aldosteronism, which is the most common cause of secondary hypertension. The KCNJ5 rs2604204 variant was shown to be common (minor allele frequency=32.5%) in Chinese patients with essential hypertension (EH). The relationship between KCNJ5 variant and plasma aldosterone (ALD) levels in EH patients has not been reported. We collected 229 patients with newly diagnosed EH without any antihypertensive agents...
January 19, 2017: Journal of Human Hypertension
https://www.readbyqxmd.com/read/28100183/short-term-blood-pressure-variability-variation-between-arm-side-body-position-and-successive-measurements-a-population-based-cohort-study
#2
Maria Elena Lacruz, Alexander Kluttig, Oliver Kuss, Daniel Tiller, Daniel Medenwald, Sebastian Nuding, Karin Halina Greiser, Stefan Frantz, Johannes Haerting
BACKGROUND: Precise blood pressure (BP) measurements are central for the diagnosis of hypertension in clinical and epidemiological studies. The purpose of this study was to quantify the variability in BP associated with arm side, body position, and successive measurements in the setting of a population-based observational study. Additionally, we aimed to evaluate the influence of different measurement conditions on prevalence of hypertension. METHODS: The sample included 967 men and 812 women aged 45 to 83 years at baseline...
January 18, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28097106/postmeal-triglyceridemia-and-variability-of-hba1c-and-postmeal-glycemia-were-predictors-of-annual-decline-in-estimated-glomerular-filtration-rate-in-type-2-diabetic-patients-with-different-stages-of-nephropathy
#3
Ayaka Tsuboi, Akiko Takenouchi, Miki Kurata, Keisuke Fukuo, Tsutomu Kazumi
BACKGROUND: This study examined associations of annual glycemic variability and postprandial dysmetabolism with annual decline in estimated glomerular filtration rate (eGFR) in type 2 diabetic patients with different stages of nephropathy. METHODS: Intrapersonal mean and coefficient of variation (CV) of HbA1c, fasting and postmeal concentrations of plasma glucose (FPG and PMPG, respectively) and serum triglycerides (FTG and PMTG, respectively) during the first 12 months after enrollment were calculated in a cohort of 168 type 2 diabetic patients: 53 with optimal albumin/creatinine ratio (ACR < 10 mg/g), 62 with high normal ACR (10-29 mg/g) and 53 with elevated ACR (≧30 mg/g)...
2017: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/28087731/increased-nbcn1-expression-na-hco3-co-transport-and-intracellular-ph-in-human-vascular-smooth-muscle-cells-with-a-risk-allele-for-hypertension
#4
Fu Liang Ng, Ebbe Boedtkjer, Katarzyna Witkowska, Meixia Ren, Ruoxin Zhang, Arthur Tucker, Christian Aalkjær, Mark J Caulfield, Shu Ye
Genome-wide association studies have revealed an association between variation at the SLC4A7 locus and blood pressure. SLC4A7 encodes the electroneutral Na(+)/HCO3 co-transporter NBCn1 which regulates intracellular pH (pHi). We conducted a functional study of variants at this locus in primary cultures of vascular smooth muscle and endothelial cells. In both cell types, we found genotype-dependent differences for rs13082711 in DNA-nuclear protein interactions, where the risk allele is associated with increased SLC4A7 expression level, NBCn1 availability and function as reflected in elevated steady-state pHi and accelerated recovery from intracellular acidosis...
January 13, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28087333/nicotinamide-nucleotide-transhydrogenase-activity-impacts-mitochondrial-redox-balance-and-the-development-of-hypertension-in-mice
#5
Igor Leskov, Amber Neville, Xinggui Shen, Sibile Pardue, Christopher G Kevil, D Neil Granger, David M Krzywanski
Oxidant stress contributes to the initiation and progression of hypertension (HTN) by enhancing endothelial dysfunction and/or causing perturbations in nitric oxide homeostasis. Differences in mitochondrial function may augment this process and provide insight into why age of onset and clinical outcomes differ among individuals from distinct ethnic groups. We have previously demonstrated that variation in normal mitochondrial function and oxidant production exists in endothelial cells from individuals of Caucasian and African-American ethnicity and that this variation contributes to endothelial dysfunction...
December 16, 2016: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28086939/feasibility-study-for-the-non-invasive-blood-pressure-estimation-based-on-ppg-morphology-normotensive-subject-study
#6
Hangsik Shin, Se Dong Min
BACKGROUND: Blood pressure is a critical bio-signal and its importance has been increased with the aged society and the growth of cardiovascular disease population. However, most of hypertensive patients have been suffered the inconvenience in monitoring blood pressure in daily life because the measurement of the blood pressure depends on the cuff-based technique. Nowadays there are many trials to measure blood pressure without cuff, especially, photoplethysmography (PPG) based research is carried out in various ways...
January 10, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28077420/polymorphisms-of-leptin-g2548a-and-leptin-receptor-q223r-and-k109r-genes-and-blood-pressure-during-pregnancy-and-the-postpartum-period-a-cohort
#7
Dayana R Farias, Ana B Franco-Sena, Fernanda Rebelo, Gil F Salles, Cláudio J Struchiner, Maisa C Martins, Gilberto Kac
BACKGROUND: The genetic component related to blood pressure (BP) changes during pregnancy is still not elucidated. Thus, the aim of the study was to evaluate the association between leptin and leptin receptor polymorphisms and systolic (SBP) and diastolic BP (DBP) variation during pregnancy and the postpartum period. METHODS: Prospective cohort of 146 women followed at a Public Health Center in Rio de Janeiro, Brazil, during pregnancy and the postpartum. SBP and DBP (mm Hg) were measured using an automatic sphygmomanometer...
February 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28076389/a-computational-study-on-the-relation-between-resting-heart-rate-and-atrial-fibrillation-hemodynamics-under-exercise
#8
Matteo Anselmino, Stefania Scarsoglio, Andrea Saglietto, Fiorenzo Gaita, Luca Ridolfi
AIMS: Clinical data indicating a heart rate (HR) target during rate control therapy for permanent atrial fibrillation (AF) and assessing its eventual relationship with reduced exercise tolerance are lacking. The present study aims at investigating the impact of resting HR on the hemodynamic response to exercise in permanent AF patients by means of a computational cardiovascular model. METHODS: The AF lumped-parameter model was run to simulate resting (1 Metabolic Equivalent of Task-MET) and various exercise conditions (4 METs: brisk walking; 6 METs: skiing; 8 METs: running), considering different resting HR (70 bpm for the slower resting HR-SHR-simulations, and 100 bpm for the higher resting HR-HHR-simulations)...
2017: PloS One
https://www.readbyqxmd.com/read/28064284/surgery-modified-pi-with-triple-bonnet-flap-and-fronto-orbital-advancement
#9
Uday Singh Raswan, Sarbjit Singh Chhiber, Altaf Umar Ramzan
INTRODUCTION: Craniosynostosis is the premature fusion of one or more of the cranial sutures and can occur as part of a syndrome or as an isolated defect. Pansynostosis is a rare form of craniosynostosis that involves premature fusion of all the cranial sutures (coronal, sagittal, metopic, and occipital). Particularly in cases of late presentation, there are heightened clinical concerns, both functional and aesthetic. In untreated cases of pansynostosis and increased intracranial pressure, optic nerve damage progresses to optic atrophy and then blindness...
January 7, 2017: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28063232/quantitative-genetic-analysis-of-the-body-composition-and-blood-pressure-association-in-two-ethnically-diverse-populations
#10
Sudipta Ghosh, Tasbulat Dosaev, Jai Prakash, Gregory Livshits
OBJECTIVES: The major aim of this study was to conduct comparative quantitative-genetic analysis of the body composition (BCP) and somatotype (STP) variation, as well as their correlations with blood pressure (BP) in two ethnically, culturally and geographically different populations: Santhal, indigenous ethnic group from India and Chuvash, indigenous population from Russia. MATERIALS AND METHODS: Correspondently two pedigree-based samples were collected from 1,262 Santhal and1,558 Chuvash individuals, respectively...
January 7, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28060537/variations-of-perioperative-baroreflex-sensitivity-in-hypertensive-and-normotensive-patients
#11
Dan Huang, Jie Zhou, Diansan Su, Weifeng Yu, Jie Chen
BACKGROUND: Impaired baroreflex sensitivity (BRS) is a marker of autonomous dysfunction, which may play an important role in the long-term development of hypertension. Perioperative patients with hypertension are rapidly increasing in all populations worldwide. OBJECTIVE: To estimate the value of BRS for hypertension in a surgery cohort. METHODS: An observational and cross-sectional study was performed, involving 96 patients who underwent video-assisted thoracoscopic pulmonary lobectomy or segmentectomy...
January 6, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28052103/bmi-and-whr-are-reflected-in-female-facial-shape-and-texture-a-geometric-morphometric-image-analysis
#12
Christine Mayer, Sonja Windhager, Katrin Schaefer, Philipp Mitteroecker
Facial markers of body composition are frequently studied in evolutionary psychology and are important in computational and forensic face recognition. We assessed the association of body mass index (BMI) and waist-to-hip ratio (WHR) with facial shape and texture (color pattern) in a sample of young Middle European women by a combination of geometric morphometrics and image analysis. Faces of women with high BMI had a wider and rounder facial outline relative to the size of the eyes and lips, and relatively lower eyebrows...
2017: PloS One
https://www.readbyqxmd.com/read/28043186/oral-propranolol-for-infantile-hemangiomas-a-prospective-study-on-the-role-of-48-hour-holter-monitoring-in-additional-safety-assessment
#13
Jelena Petrovic, Branislav Trifunovic, Goran Vukomanovic, Mirko Topalovic, Goran Trajkovic, Vojislav Parezanović
PURPOSE: Oral propranolol has been recently approved for infantile hemangiomas (IHs), but potential side effects stay a challenge. We sought to make an additional assessment on oral propranolol safety for this indication. MATERIALS AND METHODS: Prospective study included 108 infants consecutively treated for IHs at the University Children's Hospital Tirsova, Belgrade from January 2010 to December 2013. Propranolol was administered orally at a daily dose of 0.5 mg/kg and doubled every 48 hours in the absence of side effects until reaching the maximum dose of 2 mg/kg daily...
January 11, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28042082/beetroot-juice-versus-chard-gel-a-pharmacokinetic-and-pharmacodynamic-comparison-of-nitrate-bioavailability
#14
Luke C McIlvenna, Chris Monaghan, Luke Liddle, Bernadette O Fernandez, Martin Feelisch, David J Muggeridge, Chris Easton
Dietary supplementation with inorganic nitrate (NO3(-)) has been shown to induce a multitude of advantageous cardiovascular and metabolic responses during rest and exercise. While there is some suggestion that pharmacokinetics may differ depending on the NO3(-) source ingested, to the best of our knowledge this has yet to be determined experimentally. Here, we compare the plasma pharmacokinetics of NO3(-), nitrite (NO2(-)), and total nitroso species (RXNO) following oral ingestion of either NO3(-) rich beetroot juice (BR) or chard gels (GEL) with the associated changes in blood pressure (BP)...
December 29, 2016: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28035261/cellular-and-humoral-immunity-in-a-wild-mammal-variation-with-age-sex-and-association-with-overwinter-survival
#15
Rebecca L Watson, Tom N McNeilly, Kathryn A Watt, Josephine M Pemberton, Jill G Pilkington, Martin Waterfall, Phoebe R T Hopper, Daniel Cooney, Rose Zamoyska, Daniel H Nussey
Immune defenses are expected to be crucial for survival under the considerable parasite pressures experienced by wild animals. However, our understanding of the association between immunity and fitness in nature remains limited due to both the complexity of the vertebrate immune system and the often-limited availability of immune reagents in nonmodel organisms. Here, we use methods and reagents developed by veterinary researchers for domestic ungulates on blood samples collected from a wild Soay sheep population, to evaluate an unusually broad panel of immune parameters...
December 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/28034358/high-blood-pressure-combined-with-sedentary-behavior-in-young-people-a-systematic-review
#16
Loreana Sanches Silveira, Daniela Sayuri Inoue, José Messias Rodrigues da Silva, Suziane Ungari Cayres, Diego Giulliano Destro Christofaro
BACKGROUND: High blood pressure (HBP) is a cardiovascular risk factor that can initiate in childhood and adolescence and may be associated with other risk factors such as sedentary lifestyles. Therefore, verifying if these associations occur from the earliest ages is of fundamental importance. OBJECTIVES: to report the prevalence of HBP combined with sedentary behavior through a systematic review. DESIGN AND METHODS: The research was performed based on studies published between 2010 and 2016 in Medline, Web of Science, Excerpta Medica (EMBASE), and Scielo, using terms related to: 'sedentary behavior' OR 'screen time' AND ' high blood pressure'...
December 30, 2016: Current Hypertension Reviews
https://www.readbyqxmd.com/read/28032564/wearing-lead-aprons-in-surgical-operating-rooms-ergonomic-injuries-evidenced-by-infrared-thermography
#17
Dominique Alexandre, Marc Prieto, Fabien Beaumont, Redha Taiar, Guillaume Polidori
BACKGROUND: The purpose of this study is to quantify the impact of the weight of radiation protection lead aprons on the discomfort and the fatigue of the medical staff within an operating room of interventional gastroenterology. To quantify this fatigue, we analyzed variations of the physiological parameters, including heart rate, blood pressure, and cutaneous temperature; we compared two situations: the first within the classic endoscopy department (without apron) and the second within the operating room with apron...
November 2, 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/28028716/evaluation-of-the-health-status-of-six-volunteers-from-the-mars-500-project-using-pulse-analysis
#18
Hong-Zhi Shi, Quan-Chun Fan, Jian-Yi Gao, Jun-Lian Liu, Gui-E Bai, Tao Mi, Shuang Zhao, Yu Liu, Dong Xu, Zhi-Feng Guo, Yong-Zhi Li
OBJECTIVE: To comprehensively evaluate the health status of 6 volunteers from the Mars 500 Project through analyzing their pulse graphs and determining the changes in cardiovascular function, degree of fatigue and autonomic nervous function. METHODS: Six volunteers were recruited; all were male aged 26-38 years (average 31.83±4.96 years). Characteristic parameters reflflecting the status of cardiovascular functions were extracted, which included left ventricular contraction, vascular elasticity and peripheral resistance...
December 27, 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28018240/distinctive-steady-state-heart-rate-and-blood-pressure-responses-to-passive-robotic-leg-exercise-and-functional-electrical-stimulation-during-head-up-tilt
#19
Amirehsan Sarabadani Tafreshi, Robert Riener, Verena Klamroth-Marganska
Introduction: Tilt tables enable early mobilization of patients by providing verticalization. But there is a high risk of orthostatic hypotension provoked by verticalization, especially after neurological diseases such as spinal cord injury. Robot-assisted tilt tables might be an alternative as they add passive robotic leg exercise (PE) that can be enhanced with functional electrical stimulation (FES) to the verticalization, thus reducing the risk of orthostatic hypotension. We hypothesized that the influence of PE on the cardiovascular system during verticalization (i...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/28011882/mycophenolate-mofetil-prevents-cerebrovascular-injury-in-stroke-prone-spontaneously-hypertensive-rats
#20
Isha Dhande, Yaming Zhu, Michael C Braun, M John Hicks, Scott E Wenderfer, Peter A Doris
BACKGROUND AND PURPOSE: Stroke-prone spontaneously hypertensive rats (SHR-A3) develop strokes and progressive kidney disease as a result of naturally occurring genetic variations. We recently identified genetic variants in immune signaling pathways that contribute to end-organ injury. The present study was designed to test the hypothesis that a dysregulated immune response promotes stroke susceptibility. METHODS: 20-week old male SHR-A3 rats were salt loaded and treated with the immunosuppressant mycophenolate mofetil (MMF, 25 mg/kg/day, p...
December 23, 2016: Physiological Genomics
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