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https://www.readbyqxmd.com/read/28823079/mechanobiological-model-of-arterial-growth-and-remodeling
#1
Maziyar Keshavarzian, Clark A Meyer, Heather N Hayenga
A coupled agent-based model (ABM) and finite element analysis (FEA) computational framework is developed to study the interplay of bio-chemo-mechanical factors in blood vessels and their role in maintaining homeostasis. The agent-based model implements the power of REPAST Simphony libraries and adapts its environment for biological simulations. Coupling a continuum-level model (FEA) to a cellular-level model (ABM) has enabled this computational framework to capture the response of blood vessels to increased or decreased levels of growth factors, proteases and other signaling molecules (on the micro scale) as well as altered blood pressure...
August 19, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28818596/cardiometabolic-phenotypes-and-mitochondrial-dna-copy-number-in-two-cohorts-of-uk-women
#2
Anna L Guyatt, Kimberley Burrows, Philip A I Guthrie, Sue Ring, Wendy McArdle, Ian N M Day, Raimondo Ascione, Debbie A Lawlor, Tom R Gaunt, Santiago Rodriguez
The mitochondrial genome is present at variable copy number between individuals. Mitochondria are vulnerable to oxidative stress, and their dysfunction may be associated with cardiovascular disease. The association of mitochondrial DNA copy number with cardiometabolic risk factors (lipids, glycaemic traits, inflammatory markers, anthropometry and blood pressure) was assessed in two independent cohorts of European origin women, one in whom outcomes were measured at mean (SD) age 30 (4.3) years (N=2278) and the second at 69...
August 14, 2017: Mitochondrion
https://www.readbyqxmd.com/read/28812942/acute-hypertensive-response-in-patients-with-intracerebral-hemorrhage-pathophysiology-and-treatment
#3
Adnan I Qureshi, Mushtaq H Qureshi
Acute hypertensive response is a common systemic response to occurrence of intracerebral hemorrhage which has gained unique prominence due to high prevalence and association with hematoma expansion and increased mortality. Presumably, the higher systemic blood pressure predisposes to continued intraparenchymal hemorrhage by transmission of higher pressure to the damaged small arteries and may interact with hemostatic and inflammatory pathways. Therefore, intensive reduction of systolic blood pressure has been evaluated in several clinical trials as a strategy to reduce hematoma expansion and subsequent death and disability...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28807986/a-turbine-driven-ventilator-improves-adherence-to-advanced-cardiac-life-support-guidelines-during-a-cardiopulmonary-resuscitation-simulation
#4
Scott G Allen, Lara Brewer, Erik S Gillis, Nathan L Pace, Derek J Sakata, Joseph A Orr
BACKGROUND: Research has shown that increased breathing frequency during cardiopulmonary resuscitation is inversely correlated with systolic blood pressure. Rescuers often hyperventilate during cardiopulmonary resuscitation (CPR). Current American Heart Association advanced cardiac life support recommends a ventilation rate of 8 -10 breaths/min. We hypothesized that a small, turbine-driven ventilator would allow rescuers to adhere more closely to advanced cardiac life support (ACLS) guidelines...
August 14, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28806350/blood-pressure-variability-is-increasing-from-the-first-to-the-second-day-of-the-interdialytic-interval-in-hemodialysis-patients
#5
Antonios Karpetas, Charalampos Loutradis, Athanasios Bikos, Georgios Tzanis, Georgios Koutroumpas, Antonios A Lazaridis, Konstantinos Mavromatidis, Vassilios Liakopoulos, Aikaterini Papagianni, Pantelis Zebekakis, Luis M Ruilope, Gianfranco Parati, Pantelis A Sarafidis
OBJECTIVES: Patients with end-stage renal-disease under hemodialysis have increased cardiovascular risk and experience severe blood pressure (BP) fluctuations during the dialysis session and the subsequent interdialytic period. BP variability (BPV) may be an additional risk factor for cardiovascular events and preliminary data suggest increased BPV with advancing stages of chronic kidney disease. This is the first study to examine BPV during the whole intradialytic and interdialytic period in hemodialysis patients with ambulatory BP monitoring...
August 12, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28805311/mechanistic-model-for-blood-pressure-and-heart-rate-changes-produced-by-telmisartan-in-humans
#6
Dong Woo Chae, Mijeong Son, Yukyung Kim, Hankil Son, Kyungsoo Park
Telmisartan, an angiotensin receptor blocker (ARB), is indicated for the treatment of essential hypertension. This study aimed to develop a mechanistic model of telmisartan drug effect in human using non-invasive markers. Data were acquired from a previous study where telmisartan 80 mg was given once daily for 6 days. Systolic (SBP) and diastolic blood pressure (DBP) and heart rate (HR) were measured before dosing for day 1 to 5 and serially after the last dose. Mean arterial pressure (MAP) and pulse pressure (PP) were calculated from SBP and DBP...
August 14, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28804475/midterm-blood-pressure-variability-is-associated-with-poststroke-cognitive-impairment-a-prospective-cohort-study
#7
Shan Geng, Na Liu, Pin Meng, Niu Ji, Yong'an Sun, Yingda Xu, Guanghui Zhang, Xiaobing He, Zenglin Cai, Bei Wang, Bei Xu, Zaipo Li, Xiaoqin Niu, Yongjin Zhang, Bingchao Xu, Xinyu Zhou, Mingli He
OBJECTIVE: The aim of this study was to investigate the relationship between blood pressure variability (BPV) and poststroke cognitive impairment (PSCI). METHODS: Seven-hundred ninety-six patients with acute ischemic stroke were included in this study. Midterm BPV was evaluated by calculating the SD and coefficient of variation (CV, 100 × SD/mean) of systolic blood pressure (SBP) and diastolic blood pressure during the 7 days after stroke onset. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) at admission and at all follow-up visits...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28803996/perioperative-hemodynamics-and-outcomes-of-patients-on-metyrosine-undergoing-resection-of-pheochromocytoma-or-paraganglioma
#8
James J Butz, Toby N Weingarten, Alexandre N Cavalcante, Irina Bancos, William F Young, Travis J McKenzie, Darrell R Schroeder, David P Martin, Juraj Sprung
INTRODUCTION: To describe outcomes of patients with metyrosine (MET) pretreatment for abdominal surgical resection of pheochromocytoma or paraganglioma (PCC/PGL) compared with patients who had phenoxybenzamine (PBZ) pretreatment. METHODS: Retrospective review of perioperative outcomes for PCC/PGL patients treated with MET and propensity-matched comparison of MET and PBZ (MET + PBZ) with PBZ alone. RESULTS: MET preparation was given in 63 cases (26 laparoscopic and 37 open, of which 55 also received PBZ)...
August 10, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28800476/neighborhood-heterogeneity-in-health-and-well-being-among-the-elderly-in-india-evidence-from-study-on-global-ageing-and-adult-health-sage
#9
Arpita Ghosh, Christopher Millett, S V Subramanian, Santanu Pramanik
We establish a rationale for a multilevel approach in examining health among older adults. Using data on a nationally representative sample of 6560 Indian adults aged 50 years and older, we examine the extent of contextual variation between neighborhoods, after accounting for the compositional effect of individuals' background characteristics, across multiple dimensions of elderly health. The variance apportioned to neighborhoods in null intercept-only models varied widely across different health outcomes examined in the elderly - while neighborhoods accounted for only 4% of the total variation in high blood pressure at exam, 23% of the total variation in self-rated poor quality of life could be attributed to neighborhood-level differences...
August 8, 2017: Health & Place
https://www.readbyqxmd.com/read/28798988/hemodynamic-assessments-of-the-ascending-thoracic-aortic-aneurysm-using-fluid-structure-interaction-approach
#10
Han Hung Yeh, Simon W Rabkin, Dana Grecov
Current assessment and management of ascending thoracic aortic aneurysm (ATAA) rely heavily on the diameter of the ATAA and blood pressure rather than biomechanical and hemodynamic parameters such as arterial wall deformation or wall shear stress. The objective of the current study was to develop an accurate computational method for modeling the mechanical responses of the ATAA to provide additional information in patient evaluations. Fully coupled fluid structure interaction simulations were conducted using data from cases with ATAA with measured geometrical parameters in order to evaluate and analyze the change in biomechanical responses under normotensive and hypertensive conditions...
August 11, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28796889/dopamine-plasma-clearance-is-increased-in-piglets-compared-to-neonates-during-continuous-dopamine-infusion
#11
Martin B Rasmussen, Jan Bert Gramsbergen, Vibeke R Eriksen, Gorm Greisen
AIM: Piglets models have often been used to study the effects of dopamine infusion on hypotension in neonates. However, piglets need higher doses of dopamine than neonates to increase blood pressure. We investigated whether this difference was due to interspecific difference in dopamine pharmacokinetics. METHODS: Arterial blood samples were drawn from six neonates admitted to the neonatal intensive care unit of Copenhagen University Hospital and 20 newborn piglets during continuous dopamine infusion...
August 10, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28792545/contribution-of-independent-and-pleiotropic-genetic-effects-in-the-metabolic-syndrome-in-a-hypertensive-rat
#12
Man Chun John Ma, Janette M Pettus, Jessica A Jakoubek, Matthew G Traxler, Karen C Clark, Amanda K Mennie, Anne E Kwitek
Hypertension is a major risk factor for cardiovascular disease, Type 2 diabetes, and end organ failure, and is often found concomitant with disorders characteristic of the Metabolic Syndrome (MetS), including obesity, dyslipidemia, and insulin resistance. While the associated features often occur together, the pathway(s) or mechanism(s) linking hypertension in MetS are not well understood. Previous work determined that genetic variation on rat chromosome 17 (RNO17) contributes to several MetS-defining traits (including hypertension, obesity, and dyslipidemia) in the Lyon Hypertensive (LH) rat, a genetically determined MetS model...
2017: PloS One
https://www.readbyqxmd.com/read/28789618/genome-wide-copy-number-variation-analysis-identified-deletions-in-sfmbt1-associated-with-fasting-plasma-glucose-in-a-han-chinese-population
#13
Ren-Hua Chung, Yen-Feng Chiu, Yi-Jen Hung, Wen-Jane Lee, Kwan-Dun Wu, Hui-Ling Chen, Ming-Wei Lin, Yii-Der I Chen, Thomas Quertermous, Chao A Hsiung
BACKGROUND: Fasting glucose and fasting insulin are glycemic traits closely related to diabetes, and understanding the role of genetic factors in these traits can help reveal the etiology of type 2 diabetes. Although single nucleotide polymorphisms (SNPs) in several candidate genes have been found to be associated with fasting glucose and fasting insulin, copy number variations (CNVs), which have been reported to be associated with several complex traits, have not been reported for association with these two traits...
August 8, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28780553/a-national-surveillance-project-on-chronic-kidney-disease-management-in-canadian-primary-care-a-study-protocol
#14
Aminu K Bello, Paul E Ronksley, Navdeep Tangri, Alexander Singer, Allan Grill, Dorothea Nitsch, John A Queenan, Cliff Lindeman, Boglarka Soos, Elizabeth Freiheit, Delphine Tuot, Dee Mangin, Neil Drummond
INTRODUCTION: Effective chronic disease care is dependent on well-organised quality improvement (QI) strategies that monitor processes of care and outcomes for optimal care delivery. Although healthcare is provincially/territorially structured in Canada, there are national networks such as the Canadian Primary Care Sentinel Surveillance Network (CPCSSN) as important facilitators for national QI-based studies to improve chronic disease care. The goal of our study is to improve the understanding of how patients with chronic kidney disease (CKD) are managed in primary care and the variation across practices and provinces and territories to drive improvements in care delivery...
August 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/28777132/prognostic-value-of-average-home-blood-pressure-and-variability-19-year-follow-up-of-the-didima-study
#15
Angeliki Ntineri, Petros G Kalogeropoulos, Konstantinos G Kyriakoulis, Evaggelia K Aissopou, Georgia Thomopoulou, Anastasios Kollias, George S Stergiou
OBJECTIVE: The current general population study explored the prognostic value of home blood pressure (HBP) average and variability (BPV) versus office measurements (OBP). METHODS: In 1997, 665 adults of Didima, Argolida, Greece were evaluated with OBP (two visits, six readings) and HBP (3 days, 12 readings) measurements. Total mortality and cardiovascular morbidity and mortality (CVD) were assessed after 19.0 ± 1.4 years. BPV was quantified by using SD and coefficient of variation...
August 1, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28776928/patients-with-parkinson-disease-present-high-ambulatory-blood-pressure-variability
#16
Hélcio Kanegusuku, Carla Silva-Batista, Tiago Peçanha, Natan Silva-Junior, Andreia Queiroz, Luiz Costa, Marco Mello, Maria Piemonte, Carlos Ugrinowitsch, Cláudia Forjaz
Patients with Parkinson disease (PD) present blunted nocturnal blood pressure fall and similar ambulatory blood pressure variability (ABPV) measured by standard deviation (SD) and coefficient of variation (CV) compared with healthy subjects. However, these classical indices of ABPV have limited validity in individuals with circadian blood pressure alterations. New indices, such as the average of daytime and night-time standard deviation weighted by the duration of the daytime and night-time intervals (SDdn ) and the average real variability (ARV), remove the influence of the daytime and the night-time periods on ABPV...
September 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/28771832/spectracam-%C3%A2-a-new-polarized-hyperspectral-imaging-system-for-repeatable-and-reproducible-in-vivo-skin-quantification-of-melanin-total-hemoglobin-and-oxygen-saturation
#17
A Nkengne, J Robic, P Seroul, S Gueheunneux, M Jomier, K Vie
BACKGROUND: An accurate way to determine skin pigmentation is to acquire the spectral reflectance of a skin sample and to quantify chromophores by reverse calculation from physical models of light propagation. Therefore, we tested a new hyperspectral imaging device and software suite, the SpectraCam(®) system, and evaluated its accuracy to quantify skin chromophores. METHODS: Validation of the SpectraCam(®) system was performed by, firstly, comparing the known and the acquired reflectance spectra of color phantoms...
August 2, 2017: Skin Research and Technology
https://www.readbyqxmd.com/read/28763901/-diagnosis-and-treatment-experience-of-transurethral-resection-for-paraganglioma-of-urinary-bladder-in-8-cases
#18
X S Ren, W J Fu, Y P Wang, C Y Wang, X Zhang
Objective: To discuss the experience of diagnosis and treatment of transurethral resection of paraganglioma in urinary bladder. Methods: This retrospective study included 8 patients who underwent transurethral resection of paraganglioma in bladder from October 2009 to April 2015. Four males and 4 females were enrolled. The age ranged from 33 to 77 years (mean: 50.4 years), with a clinical course from 1 month to 8 years. Five cases presented with hypertension and 4 had high level of noradrenaline in blood. Preoperative ultrasound, CT and MRI were performed on every patient and the results showed all tumors were solitary and limited in bladder wall...
July 25, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28763434/comparison-of-3-hypertonic-saline-and-20-mannitol-for-reducing-intracranial-pressure-in-patients-undergoing-supratentorial-brain-tumor-surgery-a-randomized-double-blind-clinical-trial
#19
Achmet Ali, Aylin Tetik, Pulat A Sabanci, Demet Altun, Nukhet Sivrikoz, Taner Abdullah, Aydin Aydoseli, Altay Sencer, Ibrahim O Akinci
BACKGROUND: In the present study, we hypothesized that 3% hypertonic saline (HS) is more effective than 20% mannitol to reduce intracranial pressure (ICP) and to modify brain bulk in patients undergoing an elective supratentorial craniotomy. MATERIALS AND METHODS: After institutional review board approval, patients scheduled to undergo supratentorial craniotomy were enrolled into this prospective, randomized, double-blind study. The patients were monitored for routine hemodynamic parameters, depth of anesthesia, and ICP...
July 31, 2017: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/28761353/hypertension-and-blood-pressure-variability-management-practices-among-physicians-in-singapore
#20
Sajita Setia, Kannan Subramaniam, Jam Chin Tay, Boon Wee Teo
PURPOSE: There are limited data on blood pressure variability (BPV) in Singapore. The absence of updated local guidelines might contribute to variations in diagnosis, treatment and control of hypertension and BPV between physicians. This study evaluated BPV awareness, hypertension management and associated training needs in physicians from Singapore. MATERIALS AND METHODS: Physicians from Singapore were surveyed between September 8, 2016, and October 5, 2016. Those included were in public or private practice for ≥3 years, cared directly for patients ≥70% of the time and treated ≥30 patients for hypertension each month...
2017: Vascular Health and Risk Management
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