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Shulan Zhang, Jing Luo, Ziyan Wu, Dirk Roggenbuck, Peter Schierack, Dirk Reinhold, Ji Li, Xiaofeng Zeng, Fengchun Zhang, Jiaming Qian, Yongzhe Li
OBJECTIVES: There is an increasing need to identify reliable biomarkers for distinguishing Crohn's disease (CD) from other gastrointestinal disorders sharing similar clinical and pathological features. This study aimed at evaluating the diagnostic potential of antibodies to zymogen granule glycoprotein GP2 (aGP2) in a large, well-defined Chinese cohort with a special focus on their role in discriminating CD from intestinal Behçet's disease (BD) and intestinal tubercolosis (ITB). METHODS: A total of 577 subjects were prospectively enrolled, including 171 patients with CD, 208 patients with ulcerative colitis (UC), 71 with BD, 57 with ITB and 70 healthy controls (HC)...
February 15, 2018: Clinical and Translational Gastroenterology
Eugenia Rota, Nicola Morelli, Paolo Immovilli, Paola De Mitri, Donata Guidetti
RATIONALE: Numerous cases of post-infectious Guillain-Barré syndrome (GBS) have been reported in the literature. Toscana virus (TOSV) is an arthropod-borne emerging pathogen in the Mediterranean area. PATIENT CONCERNS: A 40-year-old male patient was admitted to hospital for acute facial weakness, associated to numbness paraesthesias at lower and upper limbs. The neurological examination revealed facial diplegia and reduced tendon reflexes. The nerve conduction studies documented an acute motor and sensory axonal neuropathy (AMSAN); the lumbar puncture detected albuminocytologic dissociation...
September 2017: Medicine (Baltimore)
Priya Ragunathan, Hendrik Sielaff, Lavanya Sundararaman, Goran Biuković, Malathy Sony Subramanian Manimekalai, Dhirendra Singh, Subhashri Kundu, Thorsten Wohland, Wayne Frasch, Thomas Dick, Gerhard Grüber
The F1 F0 -ATP (F-ATP) synthase is essential for growth of Mycobacterium tuberculosis , the causative agent of tuberculosis (TB). In addition to their synthase function most F-ATP synthases possess an ATP-hydrolase activity, which is coupled to proton-pumping activity. However, the mycobacterial enzyme lacks this reverse activity, but the reason for this deficiency is unclear. Here, we report that a Mycobacterium -specific, 36-amino acid long C-terminal domain in the nucleotide-binding subunit α ( Mt α) of F-ATP synthase suppresses its ATPase activity and determined the mechanism of suppression...
July 7, 2017: Journal of Biological Chemistry
Silvana Salerno
BACKGROUND: Radium discovery by Marie and Pierre Curies caused previously unknown diseases. Marie Sklodowska Curie (1867-1934) suffered from radiations effects, as did girls in the radium dial watches factories. Therapeutic effects of radium were soon discovered, its unhealthy effects were as yet unheard of. OBJECTIVES: Analysis of Marie Sklodowska Curie (Marie) and radium girls occupational exposure, taking scientific debate on radium dangerous effects into account...
February 15, 2017: La Medicina del Lavoro
Georgi Tchernev, Anastasiya A Chikoeva, Marco Tana, Claudio Tana
In the article "Transcriptional blood signatures of sarcoidosis, sarcoid-like reactions and tubercolosis and their diagnostic implications" which appeared in Volume 33, Issue 3 (2016) of Sarcoidosis, vasculitis and diffuse lung diseases, the title was given incorrectly. The correct title is "Transcriptional blood signatures of sarcoidosis, sarcoid-like reactions and tuberculosis and their diagnostic implications".
December 23, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
I Thiam, C Dial, K Doh, A M Gaye, G Woto-Gaye
Tuberculosis is endemic in Senegal. It is rate of increase and high mortality rate make it a major public health problem. The aim of this study was to describe the topographic, macroscopic, and microscopic aspects of tuberculosis lesions responsible for deaths in Dakar. This is a retrospective study of 158 autopsy reports, collected over 10 years, of deaths due to tuberculosis. The diagnosis of tuberculosis was essentially macroscopic; only equivocal cases had histological analysis. The average age at death was 47 years, and nearly all patients were men (all but 5)...
November 1, 2016: Médecine et Santé Tropicales
Georgi Tchernev, Anastasiya Atanasova Chokoeva, Marco Tana, Claudio Tana
October 7, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
Simona M Monti, Giuseppina De Simone, Katia D'Ambrosio
Bacterial infections constitute an always growing health problem worldwide. The resistance to antibiotics of an increasing number of bacterial pathogens necessitates a permanent search for new molecules with different mechanisms of action. Histidine biosynthesis is an ancient pathway found in bacteria, archaebacteria, fungi and plants but absent in mammals. This feature makes it very interesting for the study of new strategies aimed to develop novel classes of antibacterial agents. In particular, one of the enzymes involved in the histidine biosynthesis, i...
2016: Current Topics in Medicinal Chemistry
Giuseppe Lopalco, Antonio Vitale, Florenzo Iannone, Luca Cantarini
No abstract text is available yet for this article.
March 2016: Clinical and Experimental Rheumatology
Giovanna Fatiguso, Sarah Allegra, Andrea Calcagno, Lorena Baietto, Ilaria Motta, Fabio Favata, Jessica Cusato, Stefano Bonora, Giovanni Di Perri, Antonio D'Avolio
We evaluated ethambutol plasma and intracellular pharmacokinetic according to single nucleotide polymorphisms in ABCB1, OATP1B1, PXR, VDR, CYP24A1 and CYP27B1 genes. Mycobacterium tubercolosis infected patients were enrolled. Standard weight-adjusted antitubercular treatment was administered intravenously for 2 weeks and then orally. Allelic discrimination was performed by real-time PCR. Ethambutol plasma and intracellular concentrations were measured by UPLC-MS/MS methods. Twenty-four patients were included...
January 30, 2016: International Journal of Pharmaceutics
Vincenzo Maione, Alessia Ruggiero, Luigi Russo, Alfonso De Simone, Paolo Vincenzo Pedone, Gaetano Malgieri, Rita Berisio, Carla Isernia
Mycobacterium tuberculosis latent infection is maintained for years with no clinical symptoms and no adverse effects for the host. The mechanism through which dormant M. tuberculosis resuscitates and enters the cell cycle leading to tuberculosis is attracting much interest. The RPF family of proteins has been found to be responsible for bacteria resuscitation and normal proliferation. This family of proteins in M. tuberculosis is composed by five homologues (named RpfA-E) and understanding their conformational, structural and functional peculiarities is crucial to the design of therapeutic strategies...
2015: PloS One
Lorenzo Zammarchi, Gianluigi Casadei, Marianne Strohmeyer, Filippo Bartalesi, Carola Liendo, Alberto Matteelli, Maurizio Bonati, Eduardo Gotuzzo, Alessandro Bartoloni
BACKGROUND: In low-incidence countries, most tuberculosis (TB) cases occur among migrants and are caused by reactivation of latent tuberculosis infection (LTBI) acquired in the country of origin. Diagnosis and treatment of LTBI are rarely implemented to reduce the burden of TB in immigrants, partly because the cost-effectiveness profile of this intervention is uncertain. The objective of this research is to perform a review of the literature to assess the cost-effectiveness of LTBI diagnosis and treatment strategies in migrants...
September 24, 2015: BMC Health Services Research
X-H Wang, A-G Ma, X-X Han, H Liang, D Wang, E Schouten, F Kok
OBJECTIVE: The tuberculosis (TB) program was carried out in the Changji zone in northwest of China. Directly Observed Treatment, Short-Course (DOTS) is a modern control strategy against tuberculosis recommended by World Health Organization. The purpose of this work is to describe the survival of post-treatment TB (PTB) patients and to identify the risk factors associated with mortality and treatment outcomes, so that effective measures and interventions could be used to decrease the mortality rate...
2015: European Review for Medical and Pharmacological Sciences
Silvia Gonella, Lorenza Garrino, Ornellla Baldan, Valerio Dimonte
INTRODUTION: Immigration is growing and immigrants' presence is important also in the health care system, thereby services reorientation and a multicultural approach are needed. OBJECTIVE: To explore health care professionals' training needs of Turin Azienda Città della Salute e della Scienza in taking care of foreign users. METHODS: An ad hoc 4-sections questionnaire was built: (1) Knowledge, attitudes and perceptions; (2) Lived and Training; (3) Improvement in cultural competence; (4) Socio-demographic data...
October 2014: Professioni Infermieristiche
Roberto Parrella, Vincenzo Esposito, Mirella Onofrio, Giovanni Parrella, Rosaria Viglietti, Vincenzo Sangiovanni, Miriam Gargiulo, Filomena Di Martino, Annalisa Del Giudice, Giulia Santoro, Mariano Bernardo, Maria Aurora Carleo, Antonio Chirianni
BACKGROUND/AIM: HIV infection is a risk factor for re-activation of latent tubercolosis infection (LTBI). In recent years new blood tests for the detection of TB infection have been developed: Quantiferon TB Gold in Tube and TSPOT TB, which are interferon-γ releasing assays (IGRAs), have improved the identification of LTBI. In our study we have compared IGRAs and TST in HIV-positive patients with different settings of immunodeficiency. PATIENTS AND METHODS: 98 consecutive HIV patients were recruited...
January 2015: In Vivo
Emil Westerlund, Degu Jerene, Zewdie Mulissa, Inger Hallström, Bernt Lindtjørn
BACKGROUND: The Ethiopian epidemic is currently on the wane. However, the situation for infected children is in some ways lagging behind due to low treatment coverage and deficient prevention of mother-to-child transmission. Too few studies have examined HIV infected children presenting to care in low-income countries in general. Considering the presence of local variations in the nature of the epidemic a study in Ethiopia could be of special value for the continuing fight against HIV...
2014: BMC Pediatrics
Chhar Bun Paul
SESSION TITLE: Tuberculosis Case Report PostersSESSION TYPE: Case Report PosterPRESENTED ON: Sunday, March 23, 2014 at 01:15 PM - 02:15 PMINTRODUCTION: Endobronchial tuberculosis (EBTB) is defined as tuberculosis infection of tracheobronchial tree with microbial and histopathological evidence. It is present in 10-40% of patients with active pulmonary tuberculosis, and it is often misdiagnosed as bronchial asthma or lung cancer. We report a patient with endobronchial tuberculosis with a metastasis-like lesion of thoracic vertebra (T11)...
March 1, 2014: Chest
N Buonora, M Chiavarini, L Salmasi, M D Giaimo, L Minelli
INTRODUCTION: In Italy, Tubercolosis (TB) has increasingly become a disease for specific population subgroups such as immigrants. The objective of this paper is to describe the trend in TB incidence from 1999 to 2008 in Umbria: a low-incidence Italian region with high immigrants rates. METHODS: Data were obtained from the Regional Information System for Infectious Diseases. Using a linear regressions model we estimated trends for number of cases and incidence rates; with a logistic regression model we estimated the effect of a set of covariates on the probability of being affected by TB...
March 2013: Journal of Preventive Medicine and Hygiene
R Tarantino, P Donnarumma, B Fazzolari, D Marruzzo, R Delfini
OBJECTIVES: To evaluate the best treatment of Pott's disease. MATERIALS AND METHODS: 7 cases of Pott's disease were treated in the department of Neurosurgery of Sapienza University of Rome (Italy) between 2004 to 2011. RESULTS: All patients underwent surgical drainage of abscess and vertebral stabilization. In all cases culture exam showed positivity after 40 days of incubation. After surgery for a period of one year chemotherapy was administered...
2013: La Clinica Terapeutica
V Renzini, V Vullo, S Simonazzi, F Cardoni, A M Cazzella, A Costantini, A Ercole, G Esterini, I Giuri, L Leggeri, A Mastromattei, M Rivoli, P Zaino
The aim of this contribution is to explain a recent tubercolosis "prevention and control" program in health care workers. The same program was implemented in an university hospital since 2007, and revised in 2011 as a result of a new Mycobacterium tubercolosis exposure assessment in the different works environment.
July 2012: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
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