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https://www.readbyqxmd.com/read/27759000/transcriptional-blood-signatures-of-sarcoidosis-sarcoid-like-reactions-and-tubercolosis-and-their-diagnostic-implications
#1
Georgi Tchernev, Anastasiya Atanasova Chokoeva, Marco Tana, Claudio Tana
N/A.
October 7, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
https://www.readbyqxmd.com/read/27072690/l-histidinol-dehydrogenase-as-a-new-target-for-old-diseases
#2
REVIEW
Simona M Monti, Giuseppina De Simone, Katia D'Ambrosio
Bacterial infections constitute an always growing health problem worldwide. The resistance to antibiotics of an increasing number of bacterial pathogens necessitates a permanent search for new molecules with different mechanisms of action. Histidine biosynthesis is an ancient pathway found in bacteria, archaebacteria, fungi and plants but absent in mammals. This feature makes it very interesting for the study of new strategies aimed to develop novel classes of antibacterial agents. In particular, one of the enzymes involved in the histidine biosynthesis, i...
2016: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/26940429/anakinra-long-term-efficacy-and-safety-in-the-management-of-schnitzler-s-syndrome-and-latent-tuberculosis-infection
#3
LETTER
Giuseppe Lopalco, Antonio Vitale, Florenzo Iannone, Luca Cantarini
No abstract text is available yet for this article.
March 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/26642947/ethambutol-plasma-and-intracellular-pharmacokinetics-a-pharmacogenetic-study
#4
Giovanna Fatiguso, Sarah Allegra, Andrea Calcagno, Lorena Baietto, Ilaria Motta, Fabio Favata, Jessica Cusato, Stefano Bonora, Giovanni Di Perri, Antonio D'Avolio
We evaluated ethambutol plasma and intracellular pharmacokinetic according to single nucleotide polymorphisms in ABCB1, OATP1B1, PXR, VDR, CYP24A1 and CYP27B1 genes. Mycobacterium tubercolosis infected patients were enrolled. Standard weight-adjusted antitubercular treatment was administered intravenously for 2 weeks and then orally. Allelic discrimination was performed by real-time PCR. Ethambutol plasma and intracellular concentrations were measured by UPLC-MS/MS methods. Twenty-four patients were included...
January 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/26576056/nmr-structure-and-dynamics-of-the-resuscitation-promoting-factor-rpfc-catalytic-domain
#5
Vincenzo Maione, Alessia Ruggiero, Luigi Russo, Alfonso De Simone, Paolo Vincenzo Pedone, Gaetano Malgieri, Rita Berisio, Carla Isernia
Mycobacterium tuberculosis latent infection is maintained for years with no clinical symptoms and no adverse effects for the host. The mechanism through which dormant M. tuberculosis resuscitates and enters the cell cycle leading to tuberculosis is attracting much interest. The RPF family of proteins has been found to be responsible for bacteria resuscitation and normal proliferation. This family of proteins in M. tuberculosis is composed by five homologues (named RpfA-E) and understanding their conformational, structural and functional peculiarities is crucial to the design of therapeutic strategies...
2015: PloS One
https://www.readbyqxmd.com/read/26399233/a-scoping-review-of-cost-effectiveness-of-screening-and-treatment-for-latent-tubercolosis-infection-in-migrants-from-high-incidence-countries
#6
REVIEW
Lorenzo Zammarchi, Gianluigi Casadei, Marianne Strohmeyer, Filippo Bartalesi, Carola Liendo, Alberto Matteelli, Maurizio Bonati, Eduardo Gotuzzo, Alessandro Bartoloni
BACKGROUND: In low-incidence countries, most tuberculosis (TB) cases occur among migrants and are caused by reactivation of latent tuberculosis infection (LTBI) acquired in the country of origin. Diagnosis and treatment of LTBI are rarely implemented to reduce the burden of TB in immigrants, partly because the cost-effectiveness profile of this intervention is uncertain. The objective of this research is to perform a review of the literature to assess the cost-effectiveness of LTBI diagnosis and treatment strategies in migrants...
2015: BMC Health Services Research
https://www.readbyqxmd.com/read/26125264/survival-and-associated-mortality-risk-factors-among-post-treatment-pulmonary-tubercolosis-patients-in-the-northwest-of-china
#7
X-H Wang, A-G Ma, X-X Han, H Liang, D Wang, E Schouten, F Kok
OBJECTIVE: The tuberculosis (TB) program was carried out in the Changji zone in northwest of China. Directly Observed Treatment, Short-Course (DOTS) is a modern control strategy against tuberculosis recommended by World Health Organization. The purpose of this work is to describe the survival of post-treatment TB (PTB) patients and to identify the risk factors associated with mortality and treatment outcomes, so that effective measures and interventions could be used to decrease the mortality rate...
2015: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/25837478/-taking-care-of-foreign-users-what-training-is-needed-for-the-healthcare-workers-at-the-municipal-health-and-science-agency-of-torino
#8
Silvia Gonella, Lorenza Garrino, Ornellla Baldan, Valerio Dimonte
INTRODUTION: Immigration is growing and immigrants' presence is important also in the health care system, thereby services reorientation and a multicultural approach are needed. OBJECTIVE: To explore health care professionals' training needs of Turin Azienda Città della Salute e della Scienza in taking care of foreign users. METHODS: An ad hoc 4-sections questionnaire was built: (1) Knowledge, attitudes and perceptions; (2) Lived and Training; (3) Improvement in cultural competence; (4) Socio-demographic data...
October 2014: Professioni Infermieristiche
https://www.readbyqxmd.com/read/25600543/interferon-gamma-release-assays-and-tubercolin-skin-test-performance-in-different-settings-of-hiv-immunodeficiency
#9
Roberto Parrella, Vincenzo Esposito, Mirella Onofrio, Giovanni Parrella, Rosaria Viglietti, Vincenzo Sangiovanni, Miriam Gargiulo, Filomena Di Martino, Annalisa Del Giudice, Giulia Santoro, Mariano Bernardo, Maria Aurora Carleo, Antonio Chirianni
BACKGROUND/AIM: HIV infection is a risk factor for re-activation of latent tubercolosis infection (LTBI). In recent years new blood tests for the detection of TB infection have been developed: Quantiferon TB Gold in Tube and TSPOT TB, which are interferon-γ releasing assays (IGRAs), have improved the identification of LTBI. In our study we have compared IGRAs and TST in HIV-positive patients with different settings of immunodeficiency. PATIENTS AND METHODS: 98 consecutive HIV patients were recruited...
January 2015: In Vivo
https://www.readbyqxmd.com/read/25280967/pre-art-retention-in-care-and-prevalence-of-tuberculosis-among-hiv-infected-children-at-a-district-hospital-in-southern-ethiopia
#10
Emil Westerlund, Degu Jerene, Zewdie Mulissa, Inger Hallström, Bernt Lindtjørn
BACKGROUND: The Ethiopian epidemic is currently on the wane. However, the situation for infected children is in some ways lagging behind due to low treatment coverage and deficient prevention of mother-to-child transmission. Too few studies have examined HIV infected children presenting to care in low-income countries in general. Considering the presence of local variations in the nature of the epidemic a study in Ethiopia could be of special value for the continuing fight against HIV...
2014: BMC Pediatrics
https://www.readbyqxmd.com/read/24638811/an-endobronchial-tuberculosis-as-a-pulmonary-mass-with-metastasis-like-lesion-of-spine
#11
Chhar Bun Paul
SESSION TITLE: Tuberculosis Case Report PostersSESSION TYPE: Case Report PosterPRESENTED ON: Sunday, March 23, 2014 at 01:15 PM - 02:15 PMINTRODUCTION: Endobronchial tuberculosis (EBTB) is defined as tuberculosis infection of tracheobronchial tree with microbial and histopathological evidence. It is present in 10-40% of patients with active pulmonary tuberculosis, and it is often misdiagnosed as bronchial asthma or lung cancer. We report a patient with endobronchial tuberculosis with a metastasis-like lesion of thoracic vertebra (T11)...
March 1, 2014: Chest
https://www.readbyqxmd.com/read/24397003/impact-of-immigration-on-burden-of-tuberculosis-in-umbria-a-low-incidence-italian-region-with-high-immigrants-rates
#12
N Buonora, M Chiavarini, L Salmasi, M D Giaimo, L Minelli
INTRODUCTION: In Italy, Tubercolosis (TB) has increasingly become a disease for specific population subgroups such as immigrants. The objective of this paper is to describe the trend in TB incidence from 1999 to 2008 in Umbria: a low-incidence Italian region with high immigrants rates. METHODS: Data were obtained from the Regional Information System for Infectious Diseases. Using a linear regressions model we estimated trends for number of cases and incidence rates; with a logistic regression model we estimated the effect of a set of covariates on the probability of being affected by TB...
March 2013: Journal of Preventive Medicine and Hygiene
https://www.readbyqxmd.com/read/23698200/pott-s-disease-medical-and-surgical-treatment
#13
R Tarantino, P Donnarumma, B Fazzolari, D Marruzzo, R Delfini
OBJECTIVES: To evaluate the best treatment of Pott's disease. MATERIALS AND METHODS: 7 cases of Pott's disease were treated in the department of Neurosurgery of Sapienza University of Rome (Italy) between 2004 to 2011. RESULTS: All patients underwent surgical drainage of abscess and vertebral stabilization. In all cases culture exam showed positivity after 40 days of incubation. After surgery for a period of one year chemotherapy was administered...
2013: La Clinica Terapeutica
https://www.readbyqxmd.com/read/23405645/-prevention-and-control-of-tuberculosis-in-the-hospital-setting-the-new-operative-protocol-of-the-polyclinic-umberto-i
#14
V Renzini, V Vullo, S Simonazzi, F Cardoni, A M Cazzella, A Costantini, A Ercole, G Esterini, I Giuri, L Leggeri, A Mastromattei, M Rivoli, P Zaino
The aim of this contribution is to explain a recent tubercolosis "prevention and control" program in health care workers. The same program was implemented in an university hospital since 2007, and revised in 2011 as a result of a new Mycobacterium tubercolosis exposure assessment in the different works environment.
July 2012: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/23289999/-the-research-progress-of-nanotechnology-in-the-laboratory-diagnosis-and-treatment-of-tubercolosis
#15
Hui Ma, Zhong-Yi Hu, Yi-Long Wang
No abstract text is available yet for this article.
October 2012: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/23119932/tuberculous-granuloma-in-haemangiomatous-nasal-polyp
#16
Bal M S, Kanwal S, Ritu P
Tuberculosis of upper respiratory tract is quite infrequent especially the nasal involvement. Isolated cases have been reported by certain authors. A ease of nasal tubercolosis is being presented for its rare site and its association with haemangioma.
March 2003: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/23088226/endobronchial-tubercolosis-a-peculiar-feature-of-tb-often-underdiagnosed
#17
Lucio Casali, Mariano E Crapa
No abstract text is available yet for this article.
2012: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/22534662/synthesis-of-potent-inhibitors-of-%C3%AE-ketoacyl-acyl-carrier-protein-synthase-iii-as-potential-antimicrobial-agents
#18
Yan Liu, Wu Zhong, Rui-Juan Li, Song Li
Mycobacterium tuberculosis FabH, an essential enzyme in the mycolic acid biosynthetic pathway, is an attractive target for novel anti-tubercolosis agents. Structure-based design and synthesis of 1-(4-carboxybutyl)-4-(4-(substituted benzyloxy)phenyl)-1H-pyrrole-2-carboxylic acid derivatives 7a-h, a subset of eight potential FabH inhibitors, is described in this paper. The Vilsmeier-Haack reaction was employed as a key step. The structures of all the newly synthesized compounds were identified by IR, ¹H-NMR, ¹³C-NMR, ESI-MS and HRMS...
2012: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/22249644/tuberculosis-related-choriocapillaritis-multifocal-serpiginous-choroiditis-follow-up-and-precise-monitoring-of-therapy-by-indocyanine-green-angiography
#19
Giulia De Luigi, Alessandro Mantovani, Marina Papadia, Carl P Herbort
To report the case of a patient initially diagnosed with acute posterior multifocal placoid pigment epitheliopathy (APMPPE), characterized by relentless evolution despite high-dose steroid therapy. An interferon-gamma release assay (IGRA) indicated a diagnosis of suspected tuberculous choriocapillaritis and the disease responded only to massive inflammation suppressive therapy and antibiotic therapy. Case report. Review of clinical features and investigational procedures. Smoldering relentless evolution and subsequent arrest of progression could be precisely monitored by indocyanine green angiography (ICGA)...
February 2012: International Ophthalmology
https://www.readbyqxmd.com/read/22073690/-emigration-and-immigration-in-italy-1861-2011
#20
Walter Pasini
The creation of the Italian Kingdom was characterized by the mass emigration of Italian people, mainly peasants towards European and American destinations. Poverty, unemployment, diseases, like pellagra, malaria and tubercolosis forced millions of Italians to leave the Country. The phenomenon of emigration is usually divided in three periods: the mass emigration from 1976 to 1914, the second one between the two world wars, the third one from 1946 to 1976. In the last quarter of the 20th century the number of repatriations overcome expatriations and the number of immigrants from Albania, Romania, Senegal, Tunisia, China, Philippines grew up becoming more and more important...
July 2011: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
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